Journal articles: 'PhaseI'

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Roméro, Stéphane, Alain Mosset, Jean-Christian Trombe, and Pierre Macaudière. "Low-temperature process of the cubic lanthanide sesquisulfides:remarkable stabilization of the γ-Ce2S3 phasei." Journal of Materials Chemistry 7, no. 8 (1997): 1541–47. http://dx.doi.org/10.1039/a608443e.

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Baxen, Jean, and Liz Johanson Botha. "Establishing a research agenda for Foundation Phasei initial teacher education: A systematic review (1994–2014)." South African Journal of Education 36, no. 3 (August 31, 2016): 1–15. http://dx.doi.org/10.15700/saje.v36n3a1263.

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Cui, Jiujie, Haiyan Yang, Donghui Chen, Jiong Hu, Haiyan Zhang, Feng Jiao, Min Liu, Jue Liu, and Li-Wei Wang. "PhaseI/IIa Study evaluating the safety, efficacy of K-001 in advanced pancreatic ductal adenocarcinoma." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e16770-e16770. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16770.

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e16770 Background: K-001 is a potent, oral anticancer drug made from active ingredients of marine microorganisms. Its former phase I study did not observe the dose limited toxicity (DLT). Thus, further phase I/IIa trial was conducted to determine maximum tolerated dose (MTD), safety profile and antitumor effects of K-001 in advanced pancreatic ductal adenocarcinoma (PDAC). Methods: This open-label phase I/IIa study involved a dose-escalation to determine maximum tolerated dose (MTD), recommended dose (RD) of K001 in patients with pancreatic ductal adenocarcinoma, followed to obtain preliminary evidence of efficacy in patients who could potentially benefit from treatment. Results: Doses from 1350mg to 2160mg twice daily were evaluated. No dose-limiting toxic effects were observed. Totally, 47 adverse events (AE) were observed which included 27 (57.4%) grade 1 AEs, 17 (36.2%) grade 2 AEs and 3 (6.4%) grade 3 AEs. Only 2 AEs which were indigestion and gastrointestinal flatulence were affirmed to research drug and both grade 2. These two AEs were both symptoms of digestive system. For grade 3 AEs, The AEs were not dose dependent. Twelve patients were assessable for response. Clinical activity was observed at all doses tested with durable Response Evaluation Criteria in Solid Tumor (RECIST) . The objective RECIST response rate (ORR) was 0% (complete response + partial response) and the disease control rate (DCR) was 83.3% (10 of 12). Conclusions: K001 has promising efficacy and light side-effect profile. The activity observed demonstrates clinical benefit in pancreatic ductal adenocarcinoma, justifying the conduct of further studies. Clinical trial information: NCT02720666 .

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Gutin, Philip H. "Boron Neutron Capture Therapy for Glioblastoma Multiforme: Interim Results from the PhaseI/II Dose-Escalation Studies." Neurosurgery 44, no. 6 (June 1999): 1192–93. http://dx.doi.org/10.1227/00006123-199906000-00014.

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Ono, Y., M. Hino, R. Narato, Y. Tanaka, R. Kamizuru, K. Kitamura, T. Uehara, and S. Kudoh. "PhaseI/II study of paclitaxel, carboplatin and UFT in chemo-naive patients with advanced non-small lung cancer (NSCLC)." Journal of Clinical Oncology 22, no. 14_suppl (July 15, 2004): 7256. http://dx.doi.org/10.1200/jco.2004.22.14_suppl.7256.

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Ono, Y., M. Hino, R. Narato, Y. Tanaka, R. Kamizuru, K. Kitamura, T. Uehara, and S. Kudoh. "PhaseI/II study of paclitaxel, carboplatin and UFT in chemo-naive patients with advanced non-small lung cancer (NSCLC)." Journal of Clinical Oncology 22, no. 14_suppl (July 15, 2004): 7256. http://dx.doi.org/10.1200/jco.2004.22.90140.7256.

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Barcia, R., A. Allen, N. Vaninov, S. Nguyen, L. Goodale, P. Igo, A. Tilles, P. Huertas, B. Miller, and B. Parekkadan. "PhaseI/II interim analysis of extracorporeal mesenchymal Stromal cell therapy (SBI-101 Therapy) in subjects with acute kidney injury." Cytotherapy 21, no. 5 (May 2019): e5. http://dx.doi.org/10.1016/j.jcyt.2019.04.016.

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NIVDANGE, SANDIP, Chinmay Jena, and Pooja Pawar. "Nationwide CoViD-19 lockdown impact on air quality in India." MAUSAM 73, no. 1 (January 15, 2022): 115–28. http://dx.doi.org/10.54302/mausam.v73i1.1475.

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This paper discusses the comparative results of surface and satellite measurements made during the Phase1 (25 March to 14 April), Phase2 (15 April to 3 May) and Phase3 (3 May to 17May) of Covid-19 imposed lockdown periods of 2020 and those of the same locations and periods during 2019 over India. These comparative analyses are performed for Indian states and Tier 1 megacities where economic activities have been severely affected with the nationwide lockdown. The focus is on changes in the surface concentration of sulfur dioxide (SO2), carbon monoxide (CO), PM2.5 and PM10, Ozone (O3), Nitrogen dioxide (NO2) and retrieved columnar NO2 from TROPOMI and Aerosol Optical Depth (AOD) from MODIS satellite. Surface concentrations of PM2.5 were reduced by 30.59%, 31.64% and 37.06%, PM10 by 40.64%, 44.95% and 46.58%, SO2 by 16.73%, 12.13% and 6.71%, columnar NO2 by 46.34%, 45.82% and 39.58% and CO by 45.08%, 41.51% and 60.45% during lockdown periods of Phase1, Phase2 and Phase3 respectively as compared to those of 2019 periods over India. During 1st phase of lockdown, model simulated PM2.5 shows overestimations to those of observed PM2.5 mass concentrations. The model underestimates the PM2.5 to those of without reduction before lockdown and 1st phase of lockdown periods. The reduction in emissions of PM2.5, PM10, CO and columnar NO2 are discussed with the surface transportation mobility maps during the study periods. Reduction in the emissions based on the observed reduction in the surface mobility data, the model showed excellent skills in capturing the observed PM2.5 concentrations. Nevertheless, during the 1st & 3rd phases of lockdown periods AOD reduced by 5 to 40%. Surface O3 was increased by 1.52% and 5.91% during 1st and 3rd Phases of lockdown periods respectively, while decreased by -8.29% during 2nd Phase of lockdown period.

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Epenetos, Agamemnon A., Karima Karagussova, and Mahendra Deonarain. "AB1, a novel protein targeting TP53 mutated GI tumors." Journal of Clinical Oncology 40, no. 4_suppl (February 1, 2022): 96. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.096.

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96 Background: The tumor suppressor gene TP53 is one of the most frequently deleted or mutated genes in gastrointestinal cancers. Normal p53 regulates several important proteins that control cell cycle, cell death, DNA damage/repair, stemness, differentiation and other key cellular functions. If the TP53 gene is damaged, tumor suppression is severely compromised. On the other hand, and downstream of p53, p21 a potent cyclin-dependent kinase inhibitor (CKI) protein binds and inhibitsthe activity of cyclin - CDK2, - CDK1, and - CDK4/6, thus functioning as a regulator ofcell cycle progression at G 1 and S phase. It can act as de facto p53 repair/ replacement mechanism. We have thus hypothesised that, if we were able to deliver wild type p21 into all p53 mutated cancer cells, it would have a possible therapeutic effect. Methods: We have constructed recombinantly a new fusion protein, named AB1, composed of a cell penetrating protein (antennapedia) ANTP and wild type p21 and tested it in in vitro and in vivo preclinical models prior to clinical studies. AB1 could also be constructed semi-synthetically by conjugating recombinant ANTP chemically to p21 protein. Results: AB1 penetrated and killed p53 mutated cancer cells but did not kill cells that did not have p53 mutations AB1 penetrated but did not kill p53- or p21- wild-type cells. AB1 was not immunogenic in normal New Zealand White rabbits. AB1 was more cytotoxic when administered with conventionally-used chemotherapeutic agents. Conclusions: We have generated a selectively cytotoxic fusion protein against p53 mutated GI cancers which is effective when used as a single agent but more so when used in combination with chemotherapy. The phaseI/II clinical trial will include eligible patients who have p53 mutated GI cancers

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Jo, Sung-Jin, Chan-Oh Min, Dae-Woo Lee, and Kyeum-Rae Cho. "Optimal Trajectory Design of Descent/Ascent phase for a Lunar Lander With Considerable Sub-Phases." Journal of the Korean Society for Aeronautical & Space Sciences 38, no. 12 (December 1, 2010): 1184–94. http://dx.doi.org/10.5139/jksas.2010.38.12.1184.

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Schwarz, Michaela, Gokben Baskaynak, Seval Turkmen, Peter Schuld, Bernd Dorken, Peter Daniel, and le Coutre Philipp. "Bcr-Abl and Wilms Tumor Gene (WT1) Kinetics in Nilotinib (AMN107) Treated CML Patients." Blood 108, no. 11 (November 1, 2006): 2336. http://dx.doi.org/10.1182/blood.v108.11.2336.2336.

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Abstract Background: In normal hemopoesis WT1 expression is restricted to early progenitors and is rapidly down-regulated in maturing blood cells. WT1 transcript quantification therefore may be an adjunct diagnostic method in CML patients (pts) that remain Bcr-Abl positive under treatment. Especially, in advanced CML pts WT1 transcript kinetics may precede a change in Bcr-Abl kinetics and may therefore be helpful to indicate early response to treatment. Nilotinib is a potent, highly selective, second generation Bcr-Abl inhibitor which in vitro is 30-fold more potent than imatinib and is currently studied in imatinib resistant or intolerant pts. Aim: The aim of this study was to compare kinetics of Bcr-Abl and WT1 transcripts in 33 CML pts with late chronic phase (CP) or advanced disease under treatment with nilotinib. Methods: All pts were treated as part of an ongoing phaseI/II clinical trial with nilotinib at a standard dose of 400 mg BID. 20 pts were in chronic phase (CP), 4 in accelerated phase (AP) and 9 in blast crisis (BC). Among the CP pts 4/20 were enrolled because of toxicity to prior imatinib treatment. WT1 and Bcr-Abl kinetics were expressed in relation to Abl expression. Data points were taken at baseline and every 4 weeks thereafter. Quantitative PCR was carried out by Taqman-analysis. Results: The median duration of nilotinib treatment was 8 months in CP pts, 4 in AP pts and 5.5 in BC pts. The follow up of all pts ranged between 3 and 13 months. All pts received imatinib prior to nilotinib and were Bcr-Abl positive at study entry. In CP samples WT1/Abl ratios (median:1.24x10−3) were 38 fold lower than Bcr-Abl/Abl (median:4.67x10−2) ratios at baseline (p≤0.014, t-test). However, in AP and BC pts no relevant difference of WT1/Abl and Bcr-Abl/Abl baseline levels were detectable. In BC patients a more rapid decline of WT1/Abl ratios compared to Bcr-Abl/Abl ratios was observed within the first four months of nilotinib therapy. In addition, in BC pts elevation of WT1 levels preceded hematologic relapses and was detectable earlier than elevation of Bcr-Abl/Abl ratios. Conclusions:In contrast to AP and BC pts in CP pts WT1/Abl ratios were significantly lower than Bcr-Abl/Abl ratios confirming the restriction of WT1 expression to early progenitors.In BC pts under nilotinib therapy WT1/Abl ratios may be an early marker of response as compared to Bcr-Abl/Abl ratios.A stable correlation of WT1/Abl and Bcr-Abl/Abl ratios was observed in AP pts under treatment.

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Yue, J., J. Yu, S. LI, Y. Yin, T. Liu, J. Zhu, and J. Lu. "PhaseI/II clinical trial of dose escalation using daily on-line cone beam CT guided radiotherapy combined with active breath control after transcatheter arterial chemoembolization for hepatocellular carcinoma." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e15654-e15654. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15654.

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e15654 Background: The radiation dose is the key factor to improve survival of patients with hepatocellular carcinoma (HCC). The optimal way to increase radiation dose is to reduce uncertainties of target mainly due to respiratory motion and setup error in radiotherapy. Our previous study demonstrated that lipiodol can be a reliable surrogate of direct tumor targeting in Kv- cone beam CT(CBCT) for patients with good lipiodol embolization. Relying on lipiodol,the daily on-line CBCT guidance with ABC is feasible. By reducing geometric position uncertainty, as well as liver movement, the technique of ABC combined with on-line CBCT guidance can permit CTV(clinical target volume)-PTV(planning target volume) margin reduction and dose escalation. The purpose of the study is to apply the new technique for clinical application and investigate the dose escalation, toxicities and response of liver tumors with the technique combined with chemoembolization(TACE). Methods: 20 HCC patients with Child-Pugh A liver function score were treated by daily on-line CBCT guided radiotherapy relying on lipiodol combined with ABC after TACE. After current doses of 45Gy/ 9 fractions,3 fractions/weeks were delivered,the scheduled dose escalation ranged from 5 to 20Gy. Each mean liver dose not reached 23G y, V30 ( the percentage of normal liver volume with radiation dose≥30 Gy) less than 28%. Results: The planned dose escalation was finished in all subgroups. None of these patients developed Grade 2 or greater liver toxicity except two patients developed Grade 2 gastrointestinal complications and one had grade 1 acute liver toxicity.The overall immediate tumor response rate was 76.3%. 1-year overall survival rate was 80.5%. Conclusions: The technique of daily on-line CBCT guided radiotherapy combined with ABC after TACE is a safe and effective treatment which can reduce CTV-PTV margin significantly and increase target precision greatly. With the technique combined with TACE, the total irradiation dose above 65Gy is feasible in daily fraction of 5Gy. No significant financial relationships to disclose.

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Lan, Hsiang-Yun, Luke Yang, Chiao-Hsuan Lin, Kao-Hsian Hsieh, Yue-Cune Chang, and Ti Yin. "Breastmilk as a Multisensory Intervention for Relieving Pain during Newborn Screening Procedures: A Randomized Control Trial." International Journal of Environmental Research and Public Health 18, no. 24 (December 10, 2021): 13023. http://dx.doi.org/10.3390/ijerph182413023.

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The study aim was to explore the effects of multisensory breastmilk interventions on short-term pain of infants during newborn screening. This is a randomized controlled trial. A total of 120 newborns were recruited and assigned by randomization to one of three treatment conditions: Condition 1 = routine care (gentle touch + verbal comfort); Condition 2 = breastmilk odor + routine care; or Condition 3 = breastmilk odor + taste + routine care. Pain was scored with the Neonatal Infant Pain Scale (NIPS). Data were collected from video recordings at 1 min intervals over the 11 phases of heel sticks: phase 1, 5 min before heel stick without stimuli (baseline); phase 2 to phase 6 (during heel stick); and phase 7 to phase 11 (recovery). Generalized estimating equations compared differences in pain scores for newborns over phases among the three conditions. Compared with the routine care, provision of the odor and taste of breastmilk reduce NIPS scores during heel sticks (B = −4.36, SE = 0.45, p < 0.001 [phase6]), and during recovery (B = −3.29, SE = 0.42, p < 0.001 [phase7]). Our findings provide new data, which supports the use of multisensory interventions that include breastmilk odor and taste in combination with gentle touch and verbal comfort to relieve pain in infants undergoing newborn screening.

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Teixeira, J., and P. Casquinha. "Inclusion of an alcoholic Rehabilitation Unit in a general psychiatric inpatient service." European Psychiatry 26, S2 (March 2011): 1759. http://dx.doi.org/10.1016/s0924-9338(11)73463-0.

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IntroductionPatients with psychiatric disorders are admitted to psychiatric units for evaluation and treatment in the acute phase of illness.AimsTo perform a descriptive analysis of psychiatric hospitalization characteristics before (phase1) and after (phase2) the inclusion of the Rehabilitation Unit for Alcoholic Patients (RUAP).MethodsA retrospective study with clinical and statistical data analysis of patients admitted to a general Psychiatric Hospital twelve months before and after the inclusion of RUAP.ResultsThe sample had 741 patients (376 males, 365 females). Hospitalization characteristics data is presented in table1.[Hospitalization characteristics of phase 1 and 2]ConclusionSample demographic characteristics were similar in both phases. Although mood disorders were the more prevalent diagnosis, after inclusion of RUAP, Alcoholic Dependence Syndrome became the most frequently assigned diagnosis. It is also relevant the higher mean occupancy rate and the higher number of patients admitted to the service. Patients social characteristics in phase 1 and 2 need further investigation.

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Mateos, M. V., M. Hernández, J. Díaz Mediavilla, L. Palomera, M. J. Moro, J. Hernández, J. J. Lahuerta, et al. "A Phase I/II National, Multi-Center, Open-Label Study of Bortezomib Plus Melphalan and Prednisone (V-MP) in Elderly Untreated Multiple Myeloma (MM) Patients." Blood 106, no. 11 (November 16, 2005): 786. http://dx.doi.org/10.1182/blood.v106.11.786.786.

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Abstract Background: Although clearly unsatisfactory, melphalan and prednisone remains the gold standard for elderly MM patients. Therefore new treatment strategies are needed for these patients. The proteasome inhibitor bortezomib (VELCADE) has shown significant activity in refractory/relapsed MM patients. Moreover, in vitro synergy has been reported when bortezomib is combined with cytotoxic agents such as melphalan. Aim: To define the appropriate dose of bortezomib in combination with MP and to analyse the toxicity and efficacy of V-MP (in terms of response) in untreated MM pts ≥ 65 years old. Methods: Treatment schedule consisting of four 6-week cycles followed by five 5-week cycles. First, two sequential dose levels of bortezomib (1.0 and 1.3 mg/m2) (6 pts each) were explored, administered on days 1,4,8,11,22,25,29 and 32 in combination with oral melphalan, 9 mg/m2 and prednisone, 60mg/m2 once daily on days 1 to 4. When maximum tolerated dose (MTD) of bortezomib in combination with MP was defined, the cohort of pts at the MTD was expanded to up to 60 patients to further refine estimates of efficacy and toxicity (PhaseII). Results: Median age of the 60 enrolled pts was 74(65–85) and the median number of cycles so far received is 3(1–9). During PhaseI, no dose limiting toxicity(DLT) was observed in the two cohorts of pts, and the recommended dose for phaseII was 1.3 mg/m2 of bortezomib in combination with MP. 53pts are evaluable for efficacy since they have already completed at least the first cycle. Analysis of response after cycle 1 revealed a Response Rate(RR) of 72%(6%CR with Immunofixation negative(CRIF-), 2%CRIF+ and 64%Partial Response(PR)). Analysis of best response after a median of 3 cycles revealed a RR of 85%(28%CRIF-, 11%CRIF+ and 45%PR); an additional pt(2%) achieved Minor Response(MR) and 7(13%) stable disease. The toxicity was manageable. Adverse events G3-4 reported for 60 pts included: Gastrointestinal toxicity, such as nauseas(2%), vomiting(2%), diarrhoea(15%) and constipation(8%); haematological toxicity, such as anemia(12%), neutropenia(G3 in 26% and G4 in 13%) and thrombocytopenia(G3 in 33% and G4 in 13%); infection(G3 en 12% and G4 in 2%) and peripheral neuropathy(G3 in 13% and G4 in 2%). Bortezomib and melphalan dose modification was required in 6 and 2 pts, respectively. Eight pts so far have been discontinued due to toxicity related to study medication: peripheral neuropathy in 5(G2 in 1, G3 in 2 and G4 in 2), diarrhoea in 1(G3), infection in 1(G3) and prolonged thrombocytopenia in 1(G4). With a median follow up of 7 months (range:3–15), two responding pts have progressed (months +9and+10), 54(90%) are alive and 6(10%) have died. Cause of death was lung cancer diagnosed 1 month after start of study treatment(1), progressive disease(1), septic shock(2), pulmonary thromboembolism (1) and pulmonary hypertension with right ventricular insufficiency and multiorganic failure(1). Conclusion: V-MP shows a high response rate(85% with 28%CRIF-) and manageable toxicities and could replace MP as the standard of care for elderly MM pts. An international phase 3 randomized trial is in progress to examine this.

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Ponte,, Carrnen, Matilde Gracia,, Maria-José Giménez,, Lorenzo Aguilar,, Carmen Martínez Maín,, Yolanda Carpintero,, Lorena Huelves,, Antonio Carcas,, Gemma del Prado,, and Francisco Soriano,. "Urinary Concentrations and Bactericidal Activity Against Amoxicillin-Nonsusceptible Strains of Escherichia coli with Single-Dose, Oral, Sustained-Release Amoxicillin/Clavulanic Acid: A PhaseI, Open-Label, Noncomparative Clinical Trial in Healthy Volunteers." Clinical Therapeutics 27, no. 7 (July 2005): 1043–49. http://dx.doi.org/10.1016/j.clinthera.2005.07.001.

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Jia, Xisheng, Wenbin Cao, and Qiwei Hu. "Selective maintenance optimization for random phased-mission systems subject to random common cause failures." Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability 233, no. 3 (August 13, 2018): 379–400. http://dx.doi.org/10.1177/1748006x18791724.

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In both industrial and military fields, there is such a kind of complicated system termed as phased-mission system, which executes missions composed of several different phases in sequence. The structure, failure behavior, and working conditions of such a system may change from phase to phase. The duration of each phase of such a system involved is random and follows a probability distribution, and the system may suffer some events resulting in simultaneous failures of different elements with different probabilities. In order to guarantee such a system completes the phased-mission successfully, a selective maintenance model for random phased-mission systems subject to random common cause failures is proposed to optimally identify a subset of maintenance activities to be performed on some elements of the system. Thereinto, a novel analytic model is developed to estimate the probability of the maintained random phased-mission system successfully completing the phased-mission, and we compare it with a well-known Monte Carlo Simulation approach. Finally, the proposed selective maintenance model has been successfully applied to an artillery weapon system. Comparative analysis is carried out to compare the proposed model with the traditional ones, including selective maintenance models for deterministic phased-mission systems and deterministic single-phase mission systems. The results show that ignoring some mission properties (e.g. randomness and multiple phases) in selective maintenance optimization will lead to (1) incorrect system and mission modeling, (2) incorrect computation of the probability of the random phased-mission system successfully completing a mission, and/or (3) nonoptimal selective maintenance options.

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Hu, Qiguo, and Jinyin He. "Path Sets Combination Method for Reliability Analysis of Phased-Mission Systems Based on Cumulative Exposure Model." Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University 36, no. 5 (October 2018): 995–1003. http://dx.doi.org/10.1051/jnwpu/20183650995.

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The modeling of phased-mission systems is difficult and the solving process is complex because of the relevance of the phase tasks and the sharing of components existing in different phases or between phases. To solve the problem, based on the cumulative exposure model, the path sets combination method of phased-mission systems is proposed. Aiming at the problem of the cross-stage correlation of components and its different failure rate in each phase, the cumulative exposure model considering the historical damage of components is used to solve by obtaining the cumulative damage distribution of each component in each phase. Firstly, a phased-mission systems reliability model is build by mapping phased-mission system fault trees into a Bayesian network. By traversing the Bayesian network, the minimal path sets of each phase are obtained. Secondly, the disjoint formulas introduced by variable elimination method are used to do the disjoint operation of the minimal path sets of each phase and the conditional probability relations of the common components are used to reduce the minimal path sets scale. Finally, the minimum disjoint path sets of each phase are combined and summed according to the component conditional probability relation. The path sets combination method of phased-mission systems avoids the large conditional probability table, large storage and large computation problems caused by the excessive discrete states in the traditional Bayesian method and the problem that the PMS-BDD method has strict requirements for variable ordering and is difficult to solve the system reliability with multiple failure distribution types of components. In the end, a phased-mission systems reliability modeling and solving is carried out for a geosynchronous orbit satellite, and compared with the PMS-BDD method, which verifies the correctness of the method.

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Jiang, Li Ying, Bao Jian Xu, Jian Hui Xi, and Guo Xiu Fu. "Application of Phase Division Based on Dissimilarity Index in Batch Process Monitoring." Advanced Materials Research 566 (September 2012): 134–39. http://dx.doi.org/10.4028/www.scientific.net/amr.566.134.

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An important feature of batch process data is that many batch processes have multiple phases. Many different phased-based monitoring methods had been proposed. The key question of those methods is how to divide the phases of batch process. However, PCA-based methods of phase division that identify phases by extracting the first principal component of each time slice lead easily to high misclassification. In order to overcome the shortcoming of PCA-based methods, a novel phase-division method based on dissimilarity index is proposed. In proposed division method, integral information of each time slice is used to divide phases. The phase-based PCA is built in each phase to monitoring Penicillin fermentation process in order to verify performance of proposed method. The simulation results show that the proposed method is able to detect process faults more prompt and accurate than single MPCA model.

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Nguyen, Hung Q., Jim S. Whittington, John C. Devlin, Ha L. Vu, Ngoc-Vinh Vu, and Eddie Custovic. "Accurate Phase Calibration for Digital Beam-Forming in Multi-Transceiver HF Radar System." International Journal of Electronics and Telecommunications 59, no. 3 (September 1, 2013): 245–54. http://dx.doi.org/10.2478/eletel-2013-0029.

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Abstract The TIGER-3 radar is being developed as an “all digital” radar with 20 integrated digital transceivers, each connected to a separate antenna. Using phased array antenna techniques, radiated power is steered towards a desired direction based on the relative phases within the array elements. This paper proposes an accurate phase measurement method to calibrate the phases of the radio output signals using Field Programmable Gate Array (FPGA) technology. The method sequentially measures the phase offset between the RF signal generated by each transceiver and a reference signal operated at the same frequency. Accordingly, the transceiver adjusts its phase in order to align to the reference phase. This results in accurately aligned phases of the RF output signals and with the further addition of appropriate phase offsets, digital beamforming (DBF) can be performed steering the beam in a desired direction. The proposed method is implemented on a Virtex-5 VFX70T device. Experimental results show that the calibration accuracy is of 0.153 degrees with 14 MHz operating frequency.

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Richardson, Paul, S. Lonial, A. Jakubowiak, J. Wolf, A. Krishnan, J. Densmore, S. Singhal, et al. "A Multicenter Phase II Study of Perifosine (KRX-0401) Alone and in Combination with Dexamethasone (Dex) for Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM)." Blood 108, no. 11 (November 16, 2006): 3582. http://dx.doi.org/10.1182/blood.v108.11.3582.3582.

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Abstract Perifosine is an oral, novel synthetic alkylphospholipid, with multiple effects on signal transduction pathways, including inhibition of Akt and activation of JNK. Preclinical in vitro studies showed that perifosine induces significant cytotoxicity in both multiple myeloma(MM) cell lines and patient MM cells resistant to conventional therapies, and augments dexamethasone(dex), doxorubicin, melphalan and bortezomib-induced MM cell cytotoxicity. In vivo studies showed significant antitumor activity in a human plasmacytoma mouse model. PhaseI studies in solid tumors have shown that perifosine is well tolerated at a dose of up to150mg daily, with responses also seen. We report preliminary results of a PhaseII trial of perifosine, alone and in combination with dex, in patients(pts) with relapsed or relapsed/refractory MM. Pts received 150mg of perifosine daily for a 21-day(d) cycle, and were assessed by serum and/or urine electrophoresis. Eligible pts had relapsed or relapsed/refractory MM with measurable disease. Pts were permitted bisphosphonate treatment. Concomitant steroids(prednisone>10 mg/d), serum creatinine of >3.0 mg/dL, and hemoglobin<8.0g/dL within 14 d of enrollment were exclusion criteria. Progressing pts, documented on 2 occasions at least one week apart, had dex 20 mg twice per week added to perifosine. Toxicities were assessed by NCI-CTCAE, v3.0. 40 pts (22 men and 18 women, median age 61 y, range 38–78) have been treated to date. All had relapsed/refractory MM, with a median of 4 lines of prior treatment (range 1–9). Prior therapy included dex(100%), thalidomide(100%), bortezomib(73%), lenalidomide(28%) and stem cell transplant(73%). Among 25 pts currently evaluable for response, best response(EBMT criteria) to single agent perifosine after≥2 cycles was stable disease(<25% reduction in M-protein) in 6 pts(24%). Dex was added in 15 of 25 pts with PD, with 9 pts evaluable for response on the combination: 3 pts(33%) achieved MR and 2(22%) pts achieved SD. The most common adverse events included nausea (45%, 3% grade 3); vomiting (40%); diarrhea(40%); fatigue(24%, 3% grade 3), and increased creatinine(55%, 11% grade 3/4 in the context of PD and light chain nephropathy). 2 pts had G3 neutropenia which resolved. Dose reduction(150 to 100 mgs/d) was required in 11 pts and 4 pts discontinued treatment due to adverse events. Attributable toxicities otherwise proved manageable with appropriate supportive care and perifosine was generally well tolerated, with no peripheral neuropathy or DVT seen. Perifosine as monotherapy and in combination with dex has activity in pts with advanced, relapsed/refractory MM, achieving MR and/or stabilization of disease in 55% of evaluable pts to date. It was generally well tolerated, although caution in pts with renal dysfunction is warranted. PK, IHC and gene array studies are ongoing. Future studies evaluate perifosine at other dosing schedules and in combination with other agents including bortezomib.

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Yang, Errui, Guangshe Li, Yunlong Zheng, and Liping Li. "A Green Route to Hexagonal and Monoclinic BiPO4:Ln3+ (Ln = Sm, Eu, Tb, Dy) Nanocrystallites for Tailoring Luminescent Performance." Journal of Nanoscience and Nanotechnology 16, no. 4 (April 1, 2016): 3547–56. http://dx.doi.org/10.1166/jnn.2016.11836.

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Selective synthesis of specific phased nanomaterials via a green route is a promising yet challenging task. In the present work, the hexagonal and monoclinic phases of BiPO4:Ln3+ (Ln = Sm, Eu, Tb, Dy) were prepared via room temperature co-precipitation method. For adjusting the phase of the products, the prepared mediums selected were the most common solvents, i.e., water and ethanol. It was very important that the prepared mediums could be easily recycled and reused by evaporating the filtrate. The formation mechanisms of hexagonal in water and monoclinic in ethanol were investigated. Interestingly, the growth behaviors of these phases were quite distinct and thus gave rise to distinct morphology and particle size. The hexagonal phase possesses a rod-like morphology with diameters of 50–160 nm and lengths of 65–400 nm while the monoclinic phase consists of almost entirely irregular nanoparticles. Also, it was found that the bending and stretching vibrations of O–H and PO4 tetrahedra were quite different for the products prepared in water and ethanol. Moreover, it was found that the luminescence properties, including emission intensity, lifetime, quantum efficiency, and color, could be readily tailored through controlling the phase structures and microstructures. The results showed that the monoclinic phase exhibited superior luminescent performance to the hexagonal phase. The methodologies reported in this work were fundamentally important, which could be easily extended to large-scale synthesis of other phased nanomaterials for potential applications as electroluminescent devices, optical integrated circuits, or biomarkers.

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Wheeler, John F., Thomas L. Beck, S. J. Klatte, Lynn A. Cole, and John G. Dorsey. "Phase transitions of reversed-phase stationary phases." Journal of Chromatography A 656, no. 1-2 (December 1993): 317–33. http://dx.doi.org/10.1016/0021-9673(93)80807-k.

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Lu, Ning, Carine M. Vier, Ronan Casserly, Steve Dritz, Ron A. Navales, Wayne R. Cast, Danielle Wells, et al. "5 Effects of Nutrition Plans and Floor and Feeder Space on Growth Performance and Behaviors of 6- to 28-kg Nursery Pigs." Journal of Animal Science 100, Supplement_2 (April 12, 2022): 3–4. http://dx.doi.org/10.1093/jas/skac064.003.

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Abstract The objective was to determine the effects of different nutrition plans and floor and feeder space on growth performance and behaviors of 6- to 28-kg nursery pigs. A total of 1,340 pigs (PIC337×Camborough, initially 5.6±0.19 kg) were used in a 7-week trial, which was divided into 3 dietary phases (Phase1: week1, Phase2: week 2-4, and Phase3: week 5-7). Pens of pigs were weighed, blocked by body weight, and randomly allotted to 1 of 4 treatments in a 2×2 factorial design with 10 pens/treatment. Treatment factors were: 1) nutrition plans that either meet or are below PIC nutrient recommendations (lysine, amino acid to lysine ratios, and phosphorous). Diets meeting PIC recommendations had greater ME concentration by 100-150 kcal/kg; 2) floor and feeder space that either meet or are below PIC recommendations (30 or 37 pigs/pen in Phase 1 and 2, 28 or 35 pigs/pen in Phase 3). Pigs and feeders were weighed, and ear and tail lesions were scored and recorded weekly. Data were analyzed using a linear mixed model in R. There was no evidence of interaction between factors. Overall, pig fed diets containing lower nutrient levels had reduced (P < 0.05) average daily gain (ADG), average daily feed intake (ADFI), and gain to feed ratio. Pigs that were housed with less floor and feeder space had reduced (P < 0.05) ADG and ADFI in the overall period. Less floor and feeder space also resulted in a greater removal and mortality rate (P = 0.02). Pigs fed diets containing lower nutrient levels had increased incidence of ear lesions in week5 (6.06 and 2.55%, P = 0.003), week6 (12.59 and 5.45%, P < 0.001), and week7 (21.22 and 11.22%, P < 0.001). In conclusion, feeding nursery pigs below PIC nutrient recommendations and/or providing less floor and feeder space reduced growth performance, increased ear lesions incidence, and increased the removal and mortality rate.

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Mun, JunYoung, Abdolreza Hosseindoust, SangHun Ha, Joseph Moturi, Habeeb Tajudeen, and JinSoo Kim. "PSVIII-10 Calcium Chloride is a Better Calcium Source Rather Than Calcium Carbonate for Weaned Pigs." Journal of Animal Science 100, Supplement_2 (April 12, 2022): 185–86. http://dx.doi.org/10.1093/jas/skac064.313.

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Abstract This study investigated the effect of Ca source and level on growth performance, nutrient digestibility, blood profile, and bone characteristics of weaned pigs. The experiment was operated for 4 weeks in 2 phases (phase 1, d 0 to 14; and phase 2, d 15 to 28). Two hundred and forty pigs were assigned to 4 treatments including 2 Ca sources (CaCO3 and CaCl2), and 2 Ca levels (Phase 1: NC, normal Ca, 0.6% and 0.5% in phase 1 and 2, respectively; LC, low Ca, 0.5% and 0.4% in phase 1 and 2, respectively). The average daily gain (ADG) was improved in weaned pigs fed the NC or CaCl2 diets, in phase 2. The overall result showed the greater ADG and gain to feed ratio in the NC and CaCl2 treatments. The digestibility of crude protein, Ca, and P was increased in the NC and CaCl2 treatments at phases 1 and 2. There was an interaction between Ca source and level, with the NC and CaCl2 treatments increased blood chloride content in phase 1, and decreased HCO3 and base excess content in phases 1 and 2. The concentration of blood chloride was increased in pigs fed the NC diet in phase 1. The hematocrit (phases 1 and 2) and electrolyte balance (phased 2) were decreased in the NC treatment compared with the LC. An increase in blood chloride content, and a decrease in HCO3, base excess, and electrolyte balance were observed in pigs fed with CaCl2 in phases 1 and 2. The bone-breaking strength, bone ash, Ca, and P were increased in pigs fed the NC or CaCl2 diets. In conclusion, CaCl2 can be an alternative for dietary CaCO3 due to greater growth performance, nutrient digestibility, and bone health. Moreover, decreasing dietary Ca is not recommended for weaned pigs.

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Shi, Wei, Jun Zhou, Zuping Qian, and Ya Shen. "Analysis and experimental studies of compact polarization tracking modules for Ku band phased array antennas." International Journal of Microwave and Wireless Technologies 5, no. 5 (July 2, 2013): 629–36. http://dx.doi.org/10.1017/s1759078713000603.

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Detailed analysis of the polarization tracking modules for Ku band active phased array antennas is presented. The proposed transmitter (14.0–14.5 GHz) and receiver (12.25–12.75 GHz) modules are based on the low temperature co-fired ceramic (LTCC) technique, containing orthogonal dual channels with different phases controlled by phase shifters. The effect of amplitude and phase inconsistency between two channels on polarization tracking performance is analyzed. The validity of the analysis is verified by the measurements of the manufactured prototypes. The measured patterns of the active phased array antenna are given to illustrate the effects of the modules on polarization agility, which may be used for Ku band satellite antennas on mobile terminals.

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Qu, Shi Peng, and Zu Hua Jiang. "The Two Phased Method of Hull Block Assembly Sequence Planning." Advanced Materials Research 421 (December 2011): 235–39. http://dx.doi.org/10.4028/www.scientific.net/amr.421.235.

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A hull block assembly sequence planning (ASP) problem is modeled as a constraint satisfaction problem where the precedence relations between operations are considered constraints. In order to generate the proper assembly sequence of the hull block, we analyzed the structure features of the block and built the hierarchical assembly model of the block. Based on this model, we divided the whole process of the block assembly into the small subassembly phase and the unit subassembly phase. There exists the rule that the assembly process of the subassembly in the same phase is similar, and it's different to the subassembly in the different phases. So, we proposed the different methods to plan the assembly sequence of the different phases. An example is given to illustrate that this two phased method can solves the block ASP problem effectively and accurately.

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Zolcerová, Ivana. "Wortschatzerwerb im Unterricht: Wie kann man anders und dabei effektiv mit dem neuen Wortschatz arbeiten?" CASALC Review 11, no. 1 (September 30, 2021): 122. http://dx.doi.org/10.5817/casalc2021-1-10.

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Thema des vorliegenden Artikels ist die Gestaltung des effektiven Wortschatzerwerbs. Sein Hauptziel besteht darin, den Fremdsprachenlehrern unterschiedliche Lernaktivitäten zu zeigen, die in den verschiedenen Phasen der Wortschatzvermittlung benutzt werden könnten. Der vorliegende Artikel erhebt dabei keineswegs Anspruch auf Vollständigkeit in der Auflistung der Lernaktivitäten. Er soll vielmehr den Fremdsprachenlehrern neue Wege der Wortschatzvermittlung zeigen.Der Artikel gliedert sich in drei Teile. Nach der Definition der Hauptbegriffe wird auf die Rolle der Lehrkraft in der Wortschatzvermittlung aufmerksam gemacht. Weiter werden die konkreten Phasen der Wortschatzvermittlung geschildert, wobei zu jeder Phase mehrere Aktivitäten der Wortschatzvermittlung erläutert werden. The subject of this paper is an examination of the ways how vocabulary acquisition can be created. The main aim of this article is to present the phases of the vocabulary acquisition with the efficient activities suitable to each phase. The list of activities is not complete. It should work as an inspiration for other foreign language teachers for their practice. The article is divided into three parts. In the first part the main terms are defined. The second part is dedicated to the tasks of the teacher by the acquisition of vocabulary. The third part is focused on the phases of vocabulary acquisition and suitable methods for each phase.

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Ito, K., K. Tuchiya, T. Amano, M. kurita, M. kamiya, Y. Kusakabe, Y. Takehara, and A. Nozaki. "MR Cholangio-Pancreatography using a pair of surface coil : Evaluation of dual phased array coil. (2nd report)." Japanese Journal of Radiological Technology 52, no. 2 (1996): 230. http://dx.doi.org/10.6009/jjrt.kj00001354152.

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Costansa, Tamaela Ida, Marshalo Rovianto Kakerissa, and Windy Putri Latuheru. "INFLUENCE OF PROJECT METHODS ON LEARNERS' LEARNING OUTCOMES IN DRAMA COURSES IN PANDEMIC ERA." JURNAL TAHURI 19, no. 1 (February 17, 2022): 60–66. http://dx.doi.org/10.30598/tahurivol19issue1page60-66.

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The purpose of this study is to describe the effectiveness of project methods in pandemic times in drama courses in the German Language Education Study Program. The respondents in the study were fifth-semester students. The project phase in this research consists of 7 phases, namely: 1) Preparation phase (Vorbereitungsphase); 2) Early phasel (Einstiegsphase); 3) Planning phase (Planungsphase); 4) Implementation and realization phases (Ausführungsphase). 5) Evaluation and control phase (Auswertungsphase); 6) Final Results Phase (Ergebnis präsentation), and 7. Closing phase (Abschluss). According to Reich, K: Data collection techniques using qualitative descriptive methods. The end result of the project is to create a picture book about Maluku folklore (Mӓrchen). Maluku folklore book is made following the script of the drama from Esser Rolf, namely: The beginning, conflict situation, climax, redah, and end. The final results of the project showed 4 respondents got a score of 70, 3 respondents got a score of : 80, 7 respondents got a score of 90, and 3 respondents got a score of 100. Based on the assessment score of the final results of learning, it can be concluded that the project method has a positive influence on the learning outcomes of Drama courses

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Lang, Yan-Feng, Shao-Hua Tian, Zhi-Bo Yang, Wei Zhang, De-Tong Kong, Kai-Liang Xu, and Xue-Feng Chen. "Focusing phase imaging for Lamb wave phased array." Smart Materials and Structures 31, no. 2 (December 17, 2021): 025001. http://dx.doi.org/10.1088/1361-665x/ac40e0.

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Abstract In Lamb wave-based structural health monitoring, amplitude damage imaging is commonly used because the defects feature can be easily amplified by summing all the response signals together. However, the grating and side lobes affect the imaging quality and blind areas further restrict the inspection area. Considering that the existing phase-based imaging algorithms are either unfit for dispersive Lamb wave or strict to many requirements to guarantee better performance, inspired by the absence of phase information in focusing phased array, a novel focusing phase imaging (FPI) method for Lamb wave phased array is developed. The main contribution of the paper is introducing the phase information to focusing phased array. By applying the inverse-dispersion effect to the excitation signals and the superposition operation, the energy can be focused at every inspection point. The phase damage index is constructed by directly measuring the degree of consistency and alignment of the instantaneous phases. The experiments for the circular and linear array under various excitation signals with multiple defects verify that the FPI is effective for both surface damage and through-hole damage. The proposed algorithm is superior for its ability in energy focusing for defects, the capability in suppression of grating and side lobes, strong anti-disturbance ability from boundary reflection, the nonexistence of imaging blind area, and its adaptability for various excitation parameters and array layout.

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Rogers, Heather L., Pedro Pita Barros, Jan De Maeseneer, Lasse Lehtonen, Christos Lionis, Martin McKee, Luigi Siciliani, Dorothea Stahl, Jelka Zaletel, and Dionne Kringos. "Resilience Testing of Health Systems: How Can It Be Done?" International Journal of Environmental Research and Public Health 18, no. 9 (April 29, 2021): 4742. http://dx.doi.org/10.3390/ijerph18094742.

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The resilience of health systems has received considerable attention as of late, yet little is known about what a resilience test might look like. We develop a resilience test concept and methodology. We describe key components of a toolkit and a 5-phased approach to implementation of resilience testing that can be adapted to individual health systems. We develop a methodology for a test that is balanced in terms of standardization and system-specific characteristics/needs. We specify how to work with diverse stakeholders from the health ecosystem via participatory processes to assess and identify recommendations for health system strengthening. The proposed resilience test toolkit consists of “what if” adverse scenarios, a menu of health system performance elements and indicators based on an input-output-outcomes framework, a discussion guide for each adverse scenario, and a traffic light scorecard template. The five phases of implementation include Phase 0, a preparatory phase to adapt the toolkit materials; Phase 1: facilitated discussion groups with stakeholders regarding the adverse scenarios; Phase 2: supplemental data collection of relevant quantitative indicators; Phase 3: summarization of results; Phase 4: action planning and health system transformation. The toolkit and 5-phased approach can support countries to test resilience of health systems, and provides a concrete roadmap to its implementation.

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Houghton, A. W., and P. V. Brennan. "Phased array control using phase-locked-loop phase shifters." IEE Proceedings H Microwaves, Antennas and Propagation 139, no. 1 (1992): 31. http://dx.doi.org/10.1049/ip-h-2.1992.0006.

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Tuan, Wei Hsing. "Design of Multiphase Materials." Key Engineering Materials 280-283 (February 2007): 963–66. http://dx.doi.org/10.4028/www.scientific.net/kem.280-283.963.

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In the present study, several principles are introduced as the guidelines to design multi- phased materials. Each phase in the multiphase material can offer one function or property to the material. The functions contributed from the phases within the multiphase material can interact with each other. Such interactions can be tailored by suitable microstructure design. The Al2O3-ZrO2-Ni multiphase material is used to demonstrate the applications of the design principles.

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Chiba, Yuji, Toshio Omura, and Hiroshi Ichimura. "Wear resistance of arc ion-plated chromium nitride coatings." Journal of Materials Research 8, no. 5 (May 1993): 1109–15. http://dx.doi.org/10.1557/jmr.1993.1109.

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Wear resistance of arc ion-plated chromium nitride films has been studied. It has been found that texture and phases composing the films depend much on bias voltage and nitrogen gas pressure at the deposition. A phase diagram was constructed as a function of these two parameters, which indicated that three categories exist: CrN single, CrN and Cr2N dual, and CrN and Cr dual phased regions, respectively. Results of Falex No. 2 test showed that the wear resistance of CrN single phased films is superior to others, especially when (220) preferred orientation is developed. Since hardness and surface morphology do not differ much between these films, a high toughness of CrN single phased film is considered to make a difference by suppressing abrasion wear.

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36

Schuster, Julius C., and Herbert Ipser. "Phases and Phase Relations in the Partial System TiAl3-TiAl / Phasen und Phasenbeziehungen im Teilbereich TiAl3-TiAl." International Journal of Materials Research 81, no. 6 (June 1, 1990): 389–96. http://dx.doi.org/10.1515/ijmr-1990-810601.

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37

Tsau, Chun-Huei, Chen-Yu Yeh, and Meng-Chi Tsai. "The Effect of Nb-Content on the Microstructures and Corrosion Properties of CrFeCoNiNbx High-Entropy Alloys." Materials 12, no. 22 (November 11, 2019): 3716. http://dx.doi.org/10.3390/ma12223716.

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This work studied the effect of niobium-content on the microstructures, hardness, and corrosion properties of CrFeCoNiNbx alloys. Results indicated that the microstructures of these alloys changed from granular structures (CrFeCoNi alloy) to the hypereutectic structures (CrFeCoNiNb0.2 and CrFeCoNi0.4 alloys), and then to the hypoeutectic microstructures (CrFeCoNiNb0.6 and CrFeCoNi alloys). The lattice constants of the major two phases in these alloys, fcc and Laves phases (hcp), increased with the increasing of Nb-content because of solid-solution strengthening. The hardness of CrFeCoNiNbx alloys also had the same tendency. Adding niobium would slightly lessen the corrosion resistance of CrFeCoNiNbx alloys in 1 M deaerated sulfuric acid and 1 M deaerated sodium chloride solutions, but the CrFeCoNiNbx alloys still had better corrosion resistance in comparison with commercial 304 stainless steel. In these dual-phased CrFeCoNiNbx alloys, the fcc phase was more severely corroded than the Laves phase after polarization tests in these two solutions.

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38

Gilmore, Christopher, Wei Dong, and Gérard Bricogne. "A multisolution method of phase determination by combined maximization of entropy and likelihood. VI. The use of error-correcting codes as a source of phase permutation and their application to the phase problem in powder, electron and macromolecular crystallography." Acta Crystallographica Section A Foundations of Crystallography 55, no. 1 (January 1, 1999): 70–83. http://dx.doi.org/10.1107/s0108767398007909.

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The use of error-correcting codes as a source of efficient designs of phase permutation schemes is described. Three codes are used, all taken from the Bricogne BUSTER program [Bricogne (1993). Acta Cryst. D49, 37–60]: the Hamming [7, 4, 3], the Nordström–Robinson (16, 256, 6) and the Golay [24, 12, 8] or its punctured [23, 12, 7] form. These are used in a maximum-entropy–likelihood phasing environment to carry out phase permutation of basis-set reflections instead of the usual quadrant permutation or magic integer approaches. The use of codes in this way inevitably introduces some errors in the phase choices, but for most structures this is not significant especially when the gain in sampling efficiency is considered. For example, the Golay [24, 14, 8] allows the permutation of 24 centric phases in such a way that only 4096 phase sets are produced instead of 224 = 16 777 216, and one of these sets has, at most, only four wrong phases. The method is successfully applied to three powder diffraction data sets of increasing complexity, and with increasing degrees of overlap {Mg3BN3, Sigma-2 ([Si64O128]\,\cdot\,4C10H17N) and the NU-3 zeolite}, a sparse electron diffraction data set for buckminsterfullerene, C60, and the small protein molecule crambin at 3 Å resolution where 42 reflections are phased with a U-weighted mean phase error of 58.5°.

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Whitaker, T. C., and J. Hill. "Multivariate analysis of international level (CCI****) eventing competition." BSAP Occasional Publication 35 (2006): 231–34. http://dx.doi.org/10.1017/s0263967x00042786.

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Eventing is a three phased equestrian sport involving the completion of dressage, speed and endurance phases (cross country course) and show jumping phase. Penalty points are accrued during each phase of competition;. Competitors are ranked within competition on the basis of overall penalty points accrued (lowest points – winning the competition). The relative influence of each phase of the competition is currently being debated by the Federation Equestre Internationale (FEI) and its membership. The reasons for this, amongst other factors, include concerns over equine welfare, financial commitment to infrastructure and accessibility of nations developing within the sport. The essence of eventing, a speed and endurance contest, has been based around the cross country phase; the FEI refers to the phase as ‘the major test’ (FEI 2003) and British Eventing (BE) state ‘‘the relative influence on the whole competition exerted by dressage should be slightly more than that exerted by the show jumping, but considerably less than that exerted by the cross country’’ (BE 2004).

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40

Varticovski, Lyuba, Mollie H. Wright, Eloisi Caldas-Lopes, Gabriela Chiosis, and Ana I. Robles. "Synergy of the Purine-Scaffold HSP90 Inhibitor, PU-H71, with Doxorubicin in Non-Hodgkin’s Lymphoma Cell Lines." Blood 110, no. 11 (November 16, 2007): 1399. http://dx.doi.org/10.1182/blood.v110.11.1399.1399.

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Abstract For over 30 years CHOP (cyclophosphamide-doxorubicin-vincristine-prednisolone) has been the standard therapy for Diffuse Large B-cell Lymphoma (DLBCL). Although DLBCL is one of the most chemotherapy-responsive human malignancies, less than 50% of newly diagnosed patients are cured with the conventional anthracycline-based chemotherapy. Novel strategies are sought out to improve the survival of these patients. Heat Shock protein 90 (HSP90) is a molecular chaperone critical for correct conformational folding of many cellular proteins. Many of those proteins are signal-transducing regulators of cell growth, DNA damage response, and survival. Cancer cells are particularly dependent on these regulators for maintenance of the transformed phenotype. Thus, HSP90 is an attractive target for cancer therapy. HSP90 inhibitors block the ATP-binding pocket and inhibit an essential ATPase activity, altering the function of the HSP90 complex and leading to destabilization and eventual degradation of mis-folded proteins. Inhibitors of HSP90 have shown promise alone or in combination with chemotherapy or radiation in preclinical studies, and are currently undergoing PhaseI/II clinical trials. Future clinical trials on their efficacy will likely explore if any additional benefit is apparent from their combination with conventional therapies. We recently demonstrated that schedule of administration of 17DMAG following Doxorubicin (DOX) ia critical for in vitro sensitivity of DLBCL cells. We examined whether the newly developed purine-scaffold HSP90 inhibitor, PU-H71, could similarly enhance the toxicity of cells to DOX when applied 24 hours after exposure to DOX. We found that sequential addition of PU-H71 to DOX resulted in reduction of DOX IC50, from 400 nM to 75 nM. To evaluate the role of schedule of drug exposure as a determinant of the overall response, we analyzed the interaction of DOX and PU-H71 on cell survival. We applied standard criteria for synergy: the median effect/Combination Index (CI) method using an equimolar (1:1) ratio of DOX:PU-H71. Addition of PU-H71 to cells pretreated with DOX for 24 hours was consistently synergistic over the entire range of drug doses, with CI = 0.75 at Fa = 0.5. Although addition of PU-H71 prior to DOX was synergistic with CI = 0.7 at Fa = 0.5, this was only evident for higher doses. Only additive-to-antagonistic effects were observed at lower drug concentrations (Fa < 0.3). These results raise the question on whether synergy between PU-H71 and DOX will be observed at the concentrations achievable clinically. Conclusions: our observations provide a rationale for further preclinical testing and stress the need to consider schedule of exposure as a critical determinant of the overall response when designing clinical trials that combine HSP90 inhibitors with DNA damaging agents.

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Joshi, Shantaram S., Corey M. Munger, Ganapati V. Hegde, Dennis D. Weisenburger, and Julie M. Vose. "Therapeutic Effectiveness of Adaptive T-Cell Transfer for Minimal Residual Mantle Cell Lymphoma Following High Dose Therapy." Blood 110, no. 11 (November 16, 2007): 2760. http://dx.doi.org/10.1182/blood.v110.11.2760.2760.

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Abstract Mantle cell lymphoma (MCL) is the most aggressive B-cell malignancy with an overall survival of less than four years. Although high-dose therapy followed by stem cell transplantation is effective in reducing the tumor burden and increasing the survival, the patients eventually relapse due to residual lymphoma. Therefore effective therapeutic modalities are needed to target residual MCL. In this study we have developed an immune-based approach to treat minimal residual MCL. HLA matched normal donor mononuclear cells were used to generate dendric cells in vitro. Following characterization, the dendritic cells were fused with the MCL cell line Granta 519 cells to create DC/MCL hybrids. The hybrids were then used to stimulate T cells from the same donor to generate MCL-specific cytotoxic T lymphocytes (CTL). The CTLs were tested for their MCL-specific cytotoxic abilities in vitro against MCL target cells and compared to control T cells or DC primed with MCL lysate or DCs transfected with MCL RNA. HLA matched human breast cancer cell line MDA-231 was used as an irrelevant tumor target. The in vitro results showed the highest MCL specific cytotoxic effects of CTLs generated using DC-MCL hybrids for immunostimulation. As a logical next step, in vivo therapeutic affects the MCL-specific CTLs were tested using a preclinical animal model. Four groups of NOD-SCID mice, with a minimum 10 mice per group, were transplanted with Grant-519 human MCL cell line intravenously. MCL bearing mice were treated with combination chemotherapy (CHOP)over three days followed by transplantation of 1 ×106 mononuclear cells. Ten days after, mice were transplanted with 3 ×106 adoptive T cells weekly for four weeks. The results of the in vivo studies showed that, adoptively transferred T cells that had been stimulated with DC/MCL hybrids were able to significantly inhibit tumor growth in the liver (p = 0.005), kidneys (p = 0.001), and lungs (p= 0.001) of mice with minimal residual MCL compared to control tumor bearing animals as determined by analyzing tumor burden in the organs using virtual images and Neuroinformatica software. When combined with CHOP chemotherapy, adoptively transferred T cells were able to significantly (P = 0.001) extend the survival of the mice by significantly further reducing the tumor burden as compared to mice only receiving the chemotherapy plus unmanipulated T cells. Specificity of the CTL mediated response was also confirmed by cytokine profiling in vitro and in vivo. In summary, we have clearly shown that antigen-primed DCs can be used to activate MCL-specific T cells which, when administered adoptively, are effective in treating minimal residual MCL. Thus these studies lay foundation for a PhaseI/II clinical trial. (This study was supported by the Lymphoma Research Foundation, New York, NY).

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Pleiner, H., H. R. Brand, and P. E. Cladis. "Phase transitions in biaxial banana phases." Ferroelectrics 243, no. 1 (May 2000): 291–99. http://dx.doi.org/10.1080/00150190008008030.

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43

Brazhkin, V. V. "Metastable phases and ‘metastable’ phase diagrams." Journal of Physics: Condensed Matter 18, no. 42 (October 5, 2006): 9643–50. http://dx.doi.org/10.1088/0953-8984/18/42/010.

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44

Ng, T. K. "Overview of phases and phase transitions." Philosophical Magazine 95, no. 26 (September 12, 2015): 2918–47. http://dx.doi.org/10.1080/14786435.2015.1068960.

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45

Blu¨mel, Th, Peter J. Collings, H. Onusseit, and H. Stegemeyer. "Phase diagrams of the blue phases." Chemical Physics Letters 116, no. 6 (May 1985): 529–33. http://dx.doi.org/10.1016/0009-2614(85)85209-x.

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Chruściński, Dariusz. "Phase-Space Approach to Berry Phases." Open Systems & Information Dynamics 13, no. 01 (March 2006): 67–74. http://dx.doi.org/10.1007/s11080-006-7268-3.

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We propose a new formula for the adiabatic Berry phase which is based on phase-space formulation of quantum mechanics. This approach sheds a new light onto the correspondence between classical and quantum adiabatic phases — both phases are related with the averaging procedure: Hannay angle with averaging over the classical torus and Berry phase with averaging over the entire classical phase space with respect to the corresponding Wigner function.

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47

ZHU, SHI-LIANG. "GEOMETRIC PHASES AND QUANTUM PHASE TRANSITIONS." International Journal of Modern Physics B 22, no. 06 (March 10, 2008): 561–81. http://dx.doi.org/10.1142/s0217979208038855.

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Quantum phase transition is one of the main interests in the field of condensed matter physics, while geometric phase is a fundamental concept and has attracted considerable interest in the field of quantum mechanics. However, no relevant relation was recognized before recent work. In this paper, we present a review of the connection recently established between these two interesting fields: investigations in the geometric phase of the many-body systems have revealed the so-called "criticality of geometric phase", in which the geometric phase associated with the many-body ground state exhibits universality, or scaling behavior in the vicinity of the critical point. In addition, we address the recent advances on the connection of some other geometric quantities and quantum phase transitions. The closed relation recently recognized between quantum phase transitions and some of the geometric quantities may open attractive avenues and fruitful dialogue between different scientific communities.

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Huber, P., H. Krummeck, J. Baller, J. K. Krüger, K. Knorr, and S. Haussühl. "Phases and phase transitions of KPF6." Ferroelectrics 203, no. 1 (November 1997): 211–19. http://dx.doi.org/10.1080/00150199708012847.

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Follstaedt, D. M., and J. A. Knapp. "Metastable phase boundaries of quasicrystalline phases." Materials Science and Engineering 99, no. 1-2 (March 1988): 367–75. http://dx.doi.org/10.1016/0025-5416(88)90359-x.

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Sundaram, Sarvesh, and Abe Zeid. "Smart Prognostics and Health Management (SPHM) in Smart Manufacturing: An Interoperable Framework." Sensors 21, no. 18 (September 7, 2021): 5994. http://dx.doi.org/10.3390/s21185994.

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Abstract:

Advances in the manufacturing industry have led to modern approaches such as Industry 4.0, Cyber-Physical Systems, Smart Manufacturing (SM) and Digital Twins. The traditional manufacturing architecture that consisted of hierarchical layers has evolved into a hierarchy-free network in which all the areas of a manufacturing enterprise are interconnected. The field devices on the shop floor generate large amounts of data that can be useful for maintenance planning. Prognostics and Health Management (PHM) approaches use this data and help us in fault detection and Remaining Useful Life (RUL) estimation. Although there is a significant amount of research primarily focused on tool wear prediction and Condition-Based Monitoring (CBM), there is not much importance given to the multiple facets of PHM. This paper conducts a review of PHM approaches, the current research trends and proposes a three-phased interoperable framework to implement Smart Prognostics and Health Management (SPHM). The uniqueness of SPHM lies in its framework, which makes it applicable to any manufacturing operation across the industry. The framework consists of three phases: Phase 1 consists of the shopfloor setup and data acquisition steps, Phase 2 describes steps to prepare and analyze the data and Phase 3 consists of modeling, predictions and deployment. The first two phases of SPHM are addressed in detail and an overview is provided for the third phase, which is a part of ongoing research. As a use-case, the first two phases of the SPHM framework are applied to data from a milling machine operation.

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Journal articles on the topic 'PhaseI'

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