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Relevant bibliographies by topics / Pharmacology of antidepressants / Dissertations / Theses

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Dissertations / Theses on the topic 'Pharmacology of antidepressants'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Ordway, Gregory A. "Molecular Pharmacology of Antidepressants." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/8657.

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2

Wang, Haiyan. "Manipulation of ion channel function and its effects on the neuropharmacology of 5-hydroxytryptamine." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279930.

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3

Maurya, Manisha. "The effect of antidepressants on rodent brain glucocorticoid systems." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368872.

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4

Janger, Darren S. "The Collective Overuse of Antidepressants as a Psychological Defense Inhibiting Soul Opportunities." Thesis, Pacifica Graduate Institute, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10750296.

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<p> It is not the existence of depressive symptomology, but understanding the function and effect that should be central in how to best support patients. Even in cases of milder depression, phase-of-life issues, or adjustment-related depressive episodes, the myth of a magical pill, here an antidepressant, appeals to the human desire for cessation of whatever unpleasantness may be arising. As a collective, clinicians may be placating clients’ psychological defenses and natural desire to suppress or dissociate at the expense of allowing a soulful opportunity to work through and resolve cha

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5

Nomikos, George Goulielmos. "In vivo neurochemical effects of antidepressant treatments studied by microdialysis." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31076.

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The present experiments investigated the effects of different antidepressant treatments on dopamine (DA) transmission by employing in vivo microdialysis in the nucleus accumbens (NAC) and the striatum of freely moving rats. The treatments were: a) the tricyclic antidepressant desipramine (DMI), b) the novel antidepressant drug bupropion, and c) electrically induced seizures (ECS). The following results were obtained: 1) Neither acute (5 mg/kg), nor chronic (5 mg/kg, b.i.d. X 21) DMI influenced basal interstitial concentrations of DA in the NAC or the striatum. Chronic DMI did not influence ap

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6

Slamon, Noreen Deborah Louise. "Studies on the toxicological and protective responses of cultured astrocytes to antidepressants." Thesis, University of Salford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313910.

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7

Berggård, Cecilia. "Transcription Factor AP-2 in Relation to Personality and Antidepressant Drugs." Doctoral thesis, Uppsala University, Department of Neuroscience, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4638.

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<p>The CNS monoaminergic systems are considered as the head engine regulating neuropsychiatric functions and personality. Transcription factor AP-2 is known to be essential for the development of the brainstem including the monoaminergic nuclei, and has the ability to regulate many genes in the monoaminergic systems. The ability of transcription factors to regulate specific gene expression, has lately made them hot candidates as drug targets. In this thesis, results indicating a role of AP-2 in the molecular effects of the antidepressant drugs citalopram and phenelzine, are presented. </p><p>A

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8

Damberg, Mattias. "Transcription Factor AP-2 in Relation to Serotonergic Functions in the Central Nervous System." Doctoral thesis, Uppsala University, Pharmacology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2532.

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<p>Eukaryotic gene transcription plays a regulatory role in mammalian developmental processes. It has been shown that transcriptional control is an important mechanism for specification of neurotransmitter phenotypes. In the mammalian central nervous system, the transcription factor AP-2 family is one of the critical regulatory factors for neural gene expression and neuronal development. It has been shown that several genes in the monoaminergic systems have AP-2 binding sites in regulatory regions, suggesting a regulatory role of AP-2 also in the adult brain. Brainstem monoamines are implicate

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9

Gurgel, JosÃ Alves. "AvaliaÃÃo dos efeitos antiinflamatÃrios dos antidepressivos clomipramina, amitriptilina e maprotilina." Universidade Federal do CearÃ, 2002. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1187.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>No presente estudo avaliou-se os efeitos dos antidepressivos, amitriptilina (amt), clomipramina (clm) e maprotilina (mpt) em reaÃÃes inflamatÃrias. Ratos machos Wistar, 150-200g, foram divididos em cinco grupos (n=6), em experimentos de edema de pata (EP) e migraÃÃo de neutrÃfilos (MN) em bolsas de ar subcutÃnea. Amt, mpt (v.o.) e clm (i.p),10, 30 e 90mg/kg, foram administradas previamente ao estÃmulo inflamatÃrio (EI), carragenina (Cg-500 Â g/pata), fMLP (10â6M) ou dextran (Dx-300 Âg/pata). O edema foi aferido por hidropletismomet

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10

Peters, Eric James. "Pharmacogenetics of antidepressant response." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3251935.

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11

Harries, C. M. "Antidepressant activity of N-desmethylclomipramine." Thesis, Cardiff University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370790.

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12

Mann, Catherine. "Mechanisms of action of antidepressant drugs: Presynaptic and postreceptor mechanisms." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/10600.

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The etiology of clinical depression is unknown, but thought to be related to an impairment in brain transmission of monoamines. Depression is treated with antidepressant drugs which, regardless of classification, ultimately result in increased efficacy of aminergic transmission. Tricyclic antidepressants are known to inhibit the presynaptic uptake of amines. [3H]Imipramine, the prototype tricyclic antidepressant and a potential biological marker in depression, binds to both high- and a low-affinity sites in the brain. The high-affinity binding of [3H]imipramine to its binding site on the serot

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13

Longmore, J. "Investigation of the pharmacology of autonomically innervated human tissue in situ with special reference to the effects of some novel antidepressant drugs." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377654.

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14

Béïque, Jean-Claude. "The serotoninergic and noradrenergic systems : their involvement in the antidepressant effect." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0034/NQ64512.pdf.

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15

Kraft, Jeffrey Brian Jr. "Antidepressant pharmacogenetics: Searching for genetic determinants of treatment response." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311330.

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16

Mongeau, Raymond. "The serotonergic and noradrenergic systems of the hippocampus : their interactions and the effects of antidepressant treatments." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28856.

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Since the formulation of the monoaminergic hypotheses of depression, several investigations have established that the serotonin (5-HT) as well as the noradrenaline (NA) systems are altered by antidepressant treatments. In the last few years, several studies have indicated that interactions between these two systems might also be important in the mechanism of action of antidepressant drugs. We have thus undertaken: (1) to elucidate the nature of some interactions between the 5-HT and NA systems in the rat hippocampus using in vivo electrophysiology and in vitro superfusion techniques; and (2) t

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17

Piñeyro, Graciela. "Autoregulatory properties of 5-HT neurons and their modification by antidepressant treatments : focus on 5-HT release and uptake." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42118.

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The present research project was designed to analyse some of the mechanisms implicated in the autoregulation of serotonin (5-HT) function in rats and mice. It focuses on (i) the study of 5-HT reuptake activity following the long-term administration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine and the tricyclic drug tianeptine, and (ii) autoreceptor-mediated control of 5-HT release at the cell body level and its modifications following long-term antidepressant treatments.<br>The adaptative properties of the 5-HT transporter were assessed using a combined methodological approach of

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18

Haddjeri, Nasser. "Auto- and heteromodulation of the rat brain 5-HT system : involvement in the mechanism of action of antidepressant drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36978.pdf.

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19

Sinei, Kipruto Arap. "The effect of antidepressant drugs on the circadian rhythm of 5-hydroxytryptamine synthesis in the central nervous system." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375335.

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20

Szabo, Steven T. "Interactions between serotonergic and noradrenergic systems : their involvement in antidepressant treatment of anxiety and affective disorders." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37658.

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Pertubations in serotonergic (5-HT) and noradrenergic (NA) function are implicated in the pathophysiology of anxiety and affective disorders. This is strengthened by all antidepressants regardless of targeting these monoamines produce specific alterations in one or both of these systems after a prolonged administration. These alterations are congruent to their delayed onset of action in anxiety and affective disorders and may be of relevance. Using in vivo electrophysiological paradigms in the rat, the present research endeavor was undertaken to investigate whether antidepressant drugs inhibit

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21

Xu, Wanning. "The effects of antidepressant drugs on the risk of colorectal cancer : a population-based case-control study." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80898.

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Background. Experimental studies suggested that tricyclic antidepressants (TCAs) would increase the risk of cancer, whereas selective serotonin reuptake inhibitors (SSRIs) would protect against colorectal cancer.<br>Objectives. This study was carried out to examine the following hypotheses: (1) The use of TCAs increases the risk of colorectal cancer. (2) In particular, the use of genotoxic TCAs increases the risk of colorectal cancer as compared to non-genotoxic TCAs. (3) The use of (SSRIs) decreases the risk of colorectal cancer.<br>Methods. A population-based nested case-control study

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22

Thelen, Connor. "Sex Differences in the Behavioral and Neuromolecular Effects of the Rapid-Acting Antidepressant Drug Ketamine in Mice." University of Dayton / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1575964990455656.

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23

Rousse, Isabelle. "The effect of acute and chronic antidepressant treatment on cognitive processes of a transgenic mouse model with impaired type II glucocorticoid receptor function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ44329.pdf.

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24

Hojati, Ashkhan. "Pharmacologic profiling of novel compounds via fluorometric analyses of monoamine transporter responses." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5983.

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In humans and other organisms, monoaminergic systems are crucial in neuronal function and behavior. The monoamine transporters (MATs), which can be found on the presynaptic plasma membrane of neurons in the central nervous system (CNS), are crucial in the regulation of neurotransmitter concentration in the synaptic cleft. As the duration and concentration of neurotransmitters in the cleft affect further downstream signaling responses, these proteins are important targets for both understanding neuronal physiology and compounds of interest. Multiple theories exist proponing the contribution of

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25

Richer, Maxime. "Characterization of the serotonergic and noradrenergic systems in mice lacking the 5-HTA receptor and its relevance to the mechanism of action of antidepressant drugs." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33831.

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The implication of central noradrenergic and serotonergic systems in the control of mood has been known for forty years. Indeed, the different classes of molecules prescribed in the treatment of major depression directly interfere with the transmission mediated by these amines, either at the level of the synthesis, the release, the stimulation of receptors, the reuptake or the degradation. According to the leading theory in the field, the increase in serotonergic transmission is the final convergence point of currently prescribed antidepressant drugs.<br>Pharmacological and electrophysiologica

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26

Shaikh, Aamir. "Levels of PARP1-immunoreactivity in the Human Brain in Major Depressive Disorder." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/honors/547.

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MDD is a severe and debilitating disorder that is associated with a growing global economic burden due to reduced workplace productivity along with increased healthcare resource utilization. Furthermore, depression markedly enhances the risk for suicide, mortality that is especially worrisome given that 30% of depressed individuals have an inadequate response to current antidepressants. This inadequacy of antidepressants necessitates the discovery of a better understanding of the pathobiology of MDD. Most current antidepressants work through monoamine neurotransmitters, and their relative effi

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27

Lafaille, Francine. "Characterization of [125I]7-amino-8-iodo-ketanserin binding and comparative effects of long-term treatment with anxiolytic and antidepressant drugs on serotonin type 2 and beta-adrenergic receptors in rat brain." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60548.

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Changes to 5-HT$ sb2$ receptors in rat brain following antidepressant and anxiolytic treatment were investigated. The B$ sb{ rm max}$ of ($ sp{125}$I) AMIK was found to be decreased significantly in rat fronto-parietal cortex after 21 days administration of antidepressant drugs including desmethylimipramine (30%), buspirone (47%) and adinazolam (17%). The anxiolytic drug, diazepam, which is devoid of intrinsic antidepressant action, did not significantly change the binding parameters. In comparison to 5-HT$ sb2$ receptors, the beta-adrenoceptors labelled by ($ sp{125}$I) cyanopindolol in membr

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28

Franceschelli, Anthony Albert. "Sex Differences in the Rapid and the Sustained Antidepressant-like Effects of Ketamine in Stress-naive and “Depressed” Mice Exposed to Chronic Mild Stress." University of Dayton / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1429197481.

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29

O'Brien, Lisa. "Critical Determinants of the Risk-benefit Assessment of Antidepressants in Pregnancy: Pharmacokinetic, Safety and Economic Considerations." Thesis, 2009. http://hdl.handle.net/1807/24518.

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Untreated depression in pregnancy may result in adverse health outcomes to both the mother and her unborn child. Pharmacotherapy with antidepressants is the most common treatment option for depression; however, the decision to treat with medication becomes complicated by pregnancy. Risk benefit assessments are critical tools to guide the treatment decision. Factors that should be included in these analyses include the pharmacokinetics and pharmacodynamics of antidepressants in pregnancy and their maternal and fetal safety. The economic cost of untreated maternal depression is also important to

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30

Kruegel, Andrew Carry. "Chemical and Biological Explorations of Novel Opioid Receptor Modulators." Thesis, 2015. https://doi.org/10.7916/D8V1242F.

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This report describes the synthesis, chemical derivation, and pharmacological and behavioral characterization of several unique classes of opioid receptor modulators. In chapter one, a general overview of opioid receptor history, signaling biology, and therapeutic applications is provided. Also reviewed are several topics of high current interest, including, biased signaling, opioid receptor splice variants/heteromers, and applications of opioid modulators in the treatment of mood disorders. This introduction aims to frame the work that follows, and emphasize to the reader the untapped potenti

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31

Hutchinson, Ashley Nicole. "Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease." Diss., 2011. http://hdl.handle.net/10161/5033.

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<p>Activation of monoaminergic receptors is essential to the mechanism by which psychostimulants and antidepressants induce changes in behavior. Although these drugs rapidly increase monoaminergic transmission, they need to be administered for several weeks or months in order to produce long-lasting alterations in behavior. This observation suggests that it is likely that molecular mechanisms downstream of receptor activation contribute to the effects of psychostimulants and antidepressants on behavior. </p><p>Recently, we and others have demonstrated that the methyl-CpG-binding protein 2 (

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32

Gallardo, Alexis. "Antidepressivos e sua relação com o bruxismo." Master's thesis, 2018. http://hdl.handle.net/10284/7310.

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O bruxismo é uma parafunção oral que pode ocorrer durante a vigília e/ou durante o sono e que pode apresentar características patológicas ou apenas ser considerado um comportamento oral. Devido à etiologia multifatorial, dificuldade de caracterização e diagnóstico, a sua definição tem sofrido múltiplas alterações e ainda não há um consenso universalmente aceite. Nas situações de depressão, ansiedade crónica associada a distúrbios do pânico e quadros dolorosos crónicos são muitas vezes utilizados medicamentos antidepressivos, tendo sido frequentemente associado a aparecimento de bruxismo secun

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33

Romeas, Thomas. "Changements dans le circuit de la récompense suite à la bulbectomie olfactive : une nouvelle approche pour étudier des antidépresseurs." Thèse, 2009. http://hdl.handle.net/1866/2975.

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La dépression est une maladie chronique, récurrente et potentiellement mortelle qui affecte plus de 20 % de la population à travers le monde. Les mécanismes sous-jacents de la dépression demeurent incompris et la pharmacothérapie actuelle, largement basée sur l’hypothèse monoaminergique, fait preuve d’une efficacité sous optimale et d’une latence thérapeutique élevée. Par conséquent, la recherche est amenée à élaborer de nouveaux traitements pharmacologiques. Pour détecter leur action, il est avant tout nécessaire de développer des outils expérimentaux adéquats. Dans cette optique, notre but a

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34

Younes, Stephane Y. "Les récepteurs 5-HT4b adoptent différentes conformations ligand-spécifique ayant des propriétés de signalisation et de régulation distinctes." Thèse, 2012. http://hdl.handle.net/1866/8906.

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Les antidépresseurs actuels sont très similaires au niveau de leur mécanisme d’action et sont plus ou moins efficaces. Un des problèmes majeurs est leur long temps de latence à fournir une action thérapeutique dû aux adaptations des sites pré et post synaptiques. Dans un modèle animal, nous avons récemment découvert que l’agoniste RS67333 des récepteurs 5-HT4 était en mesure de produire en trois jours les mêmes effets antidépresseurs qui normalement prennent de deux à trois semaines à apparaître avec les antidépresseurs actuellement disponibles. De plus, nous avons constaté que les effets ant

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35

Lu, Jennifer. "Characterization of the membrane transporter OATP1A2 activity towards different classes of drugs." Thèse, 2016. http://hdl.handle.net/1866/19272.

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Les transporteurs membranaires sont des éléments importants dans le devenir, l’efficacité, et la toxicité du médicament. Ils influencent la pharmacocinétique et la pharmacodynamie de ces derniers. Plusieurs interactions médicamenteuses observées cliniquement sont attribuables à la fois aux enzymes responsables du métabolisme des médicaments et aux transporteurs membranaires. Il est connu qu’une variabilité existe entre différents individus dans la réponse à un médicament et les polymorphismes génétiques retrouvés dans les gènes codant pour les transporteurs membranaires peuvent partiellement e

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36

Trottier, Giacomo. "The biasing of the 5-HT4 receptor as an antidepressant target." Thèse, 2017. http://hdl.handle.net/1866/18903.

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La dépression majeure peut être très dommageable pour le 8% des Nord-Américains qui en souffriront au moins une fois durant leur vie. Les traitements actuels de la dépression ont été créés grâce à la compréhension de l'hypothèse de la monoamine; où les transporteurs de la sérotonine ou les enzymes sont bloqués ou inhibés afin de maintenir le neurotransmetteur (NT) dans la fente synaptique. Sur une période de plusieurs semaines, cette augmentation de NT encourage la plasticité synaptique, ce qui augmente la sensibilité de réponse de 5-HT dans la fente synaptique. Cette forme de traitement est e

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