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Journal articles on the topic 'Pharmaceutical chemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Olivero, Roberto. "The pharmaceutical chemist Juan José Olivero, reference of uruguayan science and the pharmaceutical industry." Anales de la Real Academia Nacional de Farmacia 89, no. 89(03) (September 30, 2023): 387–94. http://dx.doi.org/10.53519/analesranf.2023.89.03.10.

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Pharmaceutical chemist (doctor) Juan José Olivero Muñoz (Buenos Aires, 1921-Montevideo, 1993) was one of the outstanding professionals in the uruguayan pharmaceutical teaching and industry. He worked as a technician in the laboratories Athena; EMAR (Eduardo Márques Castro S. A.) and Dispert. A specialist in antibiotics, he also developed different products. He studied chloromycetin, publishing in Annals of the Uruguayan Chemistry anf Pharmacy Association and Chemical Abstracts. He was author of papers on hydrotropization in pharmaceutical technology; chemical titration of diphenhydramine hydrochloride elixir and solvotropization of steroid hormones. He wrote several chapters of the encyclopedia Theoretical and practical Pharmacotechnics, a reference text. He was president of the Uruguayan Chemistry and Pharmacy Association and was a professor and advisor of the Faculty of Chemistry in several subjects, mainly Pharmacotechnics. From 1966 until his death, he was a member of the Royal National Academy of Pharmacy (Spain), an honor to which few chemists had access in our country. After his death, he was recognized as one of the leading figures of the profession in Uruguay.

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2

Lafont, Olivier. "Pharmaceutical Chemistry." European Journal of Medicinal Chemistry 37, no. 8 (August 2002): 707. http://dx.doi.org/10.1016/s0223-5234(02)01395-8.

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3

Tauro, Dr Savita J., and Jineetkumar B. Gawad. "Green Chemistry: A Boon to Pharmaceutical Synthesis." International Journal of Scientific Research 2, no. 7 (June 1, 2012): 67–69. http://dx.doi.org/10.15373/22778179/july2013/22.

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4

Gopiwad, Prachit. "Medicinal chemistry of catechol, a versatile pharmacophore." Current Trends in Pharmacy and Pharmaceutical Chemistry 6, no. 1 (February 15, 2024): 7–11. http://dx.doi.org/10.18231/j.ctppc.2024.003.

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Catechol being a versatile pharmacophore, used in medicine as a molecular group in adjunction with other moieties and functional groups. The versatile pharmacophore has rendered several useful pharmaceuticals so far. The major medicines or the pharmaceutical drugs containing catechol moiety include levodopa, carbidopa, and several others. The FDA approved pharmaceutical preparations have been highlighted and reviewed in this paper.

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5

Mondal, Dipayan, Pankaj Lal Kalar, Shivam Kori, Shovanlal Gayen, and Kalpataru Das. "Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications." Current Organic Chemistry 24, no. 22 (December 18, 2020): 2665–93. http://dx.doi.org/10.2174/1385272824999201111203812.

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Indole moiety is often found in different classes of pharmaceutically active molecules having various biological activities including anticancer, anti-viral, anti-psychotic, antihypertensive, anti-migraine, anti-arthritis and analgesic activities. Due to enormous applications of indole derivatives in pharmaceutical chemistry, a number of conventional synthetic methods as well as green methodology have been developed for their synthesis. Green methodology has many advantages including high yields, short reaction time, and inexpensive reagents, highly efficient and environmentally benign over conventional methods. Currently, the researchers in academia as well as in pharmaceutical industries have been developing various methods for the chemical synthesis of indole based compounds via green approaches to overcome the drawbacks of conventional methods. This review reflects the last ten years developments of the various greener methods for the synthesis of indole derivatives by using microwave, ionic liquids, water, ultrasound, nanocatalyst, green catalyst, multicomponent reaction and solvent-free reactions etc. (please see the scheme below). Furthermore, the applications of green chemistry towards developments of indole containing pharmaceuticals and their biological studies have been represented in this review.

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6

Vose, Colin W., Robin Whelpton, Alison E. Ashcroft, Jeremy R. Everett, J. K. Nicholson, I. D. Wilson, Andrew J. Hutt, E. David Morgan, Huiping Huang, and Ian D. Wilson. "Biomedical and pharmaceutical chemistry." Analytical Proceedings 28, no. 6 (1991): 177. http://dx.doi.org/10.1039/ap9912800177.

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7

Byrn, S. R., R. R. Pfeiffer, G. Stephenson, D. J. W. Grant, and W. B. Gleason. "Solid-State Pharmaceutical Chemistry." Chemistry of Materials 6, no. 8 (August 1994): 1148–58. http://dx.doi.org/10.1021/cm00044a013.

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8

Veronese, F. M., and M. Morpurgo. "Bioconjugation in pharmaceutical chemistry." Il Farmaco 54, no. 8 (August 1999): 497–516. http://dx.doi.org/10.1016/s0014-827x(99)00066-x.

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9

Ahsan, Haseeb, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee, and Jong Kyung Sonn. "Significance of Green Synthetic Chemistry from a Pharmaceutical Perspective." Current Pharmaceutical Design 26, no. 45 (December 24, 2020): 5767–82. http://dx.doi.org/10.2174/1381612826666200928160851.

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Background: Conventional practices of synthesis, manufacturing, and processing have led to severe adverse consequences for living beings and the environment. Objectives: Although medications cannot be replaced, the methods of synthesizing, manufacturing, and processing them can be changed and/or replaced. This paper explains the significance of green chemistry practices in the pharmaceutical industry. It emphasizes that we must replace conventional drug synthesis, processing, and manufacturing techniques with greener ones that are cost-effective, sustainable, environment-friendly, and profitable. Discussion: This paper comprises five sections. Section 1 is an introduction to green chemistry and its correlation with the pharmaceutical industry. Section 2 discusses the metrics necessary to measure the greenness of a process. Section 3 is about solvents used in the pharmaceutical industry, hazards, safety status, and environmental effects, including the ozone depletion potential. Section 4 explains catalytic amidation reactions because amides are one of the most commonly occurring functional groups with pharmacological activity. Section 5 discusses successful cases of converting conventional synthesis of active pharmaceutical ingredients and/or their intermediates to greener, sustainable alternatives. Conclusion: A balance is necessary between profits, processes, consumers, and the environment to ensure the survival of all stakeholders and decrease the environmental burden of pharmaceuticals. Incentives such as green chemistry awards should be endorsed and encouraged, in addition to making green chemistry part of tertiary education. In addition, changes to rules and regulations for drug approval in the context of green chemistry principles are necessary in order to preserve our planet for future generations.

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10

Cheaburu-Yilmaz, Catalina Natalia, Sinem Yaprak Karavana, and Onur Yilmaz. "Functionalized Chitosan for Pharmaceutical Applications." Current Organic Synthesis 14, no. 6 (September 28, 2017): 785–97. http://dx.doi.org/10.2174/1570179414666161115150818.

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Background: Chitosan structure versatility toward a change in an external stimulus represents a “must have” for the pharmaceutical applications, especially for the pharmaceutical formulations. Chemical modification can open new ways to obtain materials with tailored properties. Despite the great interest for conventional graft modifications, controlled/living free radical polymerizations (i.e. RAFT, ATRP, etc.) and advanced chemistry techniques (i.e. click chemistry) seem more attractive nowadays and involve facile and fast procedure, high regioselectivity, quantitative yield, mild reaction conditions without generation of by-products. Objective: The present review provides a detailed state of art of the chemical modification of chitosan i.e. tailored side-chain functionalization using RAFT polymerization and click chemistry for specific applications within pharmaceutical formulations taking into account the applicative aspect regarding the need of pharmaceuticals. Conclusion: The review showed the routes of current approaches for side chain modification of chitosan including graft, block copolymers or other structural variations. The esterification of RAFT agents on chitosan by using carbonyl activating reagents enables producing chitosan graft and block copolymers with controlled architectures while the development of protection/ deprotection chemistry of chitosan made possible the regioselective modification of chitosan or other polysaccharides. Although these developments increased the potential of chitosan, still the chemical functionality and architectural diversity of the derivatives are limited. Application of modern techniques e.g. RAFT polymerization, “click” chemistry has opened new “doors” for the science of controlled and chemoselective synthesis of well- tailored derivatives with unique and superior properties.

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11

Potseluyeva, L. A. "Higher pharmaceutical education in the Republic of Tatarstan: sources of formation of educational basis, it’s development, improvement, results and achievements." Kazan medical journal 93, no. 5 (October 15, 2012): 705–11. http://dx.doi.org/10.17816/kmj1692.

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The analysis of historical and bibliographic data of pharmaceutical education foundation in the Republic of Tatarstan is presented. Over than 200-year history of higher education in Kazan, started in 1804, determined the development of not only medical, but also pharmaceutical sciences. In Kazan Emperor’s University 4 faculties were founded, including the Faculty of Medical Sciences, that included the combined Department of chemistry, technology and pharmacy (pharmaceutics), which actually consisted of several departments. The Pharmaceutical Faculty was established in Kazan Medical Institute in 1975. Departments of Pharmaceutical, analytical and toxicological chemistry, Pharmaceutical technologies, Pharmacognosy and botany, Organization and economics of pharmacy were created. First pharmacists were graduated at 1980. By June 2012, 2472 full-time students were granted the diplomas of pharmacists, 2418 were Russian citizens, 54 - foreigners. In 1998, Department of part-time education was established at Pharmaceutical Faculty, which has already graduated 606 pharmacists. Alumni of Pharmaceutical Faculty of Kazan State Medical University occupy the highest supervising posts at pharmacy network and pharmaceutical industry, which is the clear evidence of the highest quality of education they have received at the University.

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12

BLAGBROUGH, IAN S., and P. NICHOLAS SHAW. "Of Medicinal Chemistry, Pharmaceutical Sciences, and Pharmaceutical Science Communications." Journal of Pharmacy and Pharmacology 48, no. 2 (February 1996): 117–18. http://dx.doi.org/10.1111/j.2042-7158.1996.tb07110.x.

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13

Alrbaihat, Mohammad, and Ehab AlShamaileh. "Mechanochemistry’s role in non-steroidal anti-inflammatorydrugs development: A review." BOHR International Journal of General and Internal Medicine 1, no. 1 (2022): 17–24. http://dx.doi.org/10.54646/bijgim.2022.05.

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As a greener method of preparing molecules, mechanochemistry has recently been identified as an ideal strategyfor preparing diverse molecules. It is becoming a valuable synthetic tool for multiple fields (e.g., physics, chemistry,and materials science) because it can be performed without solvents or with minimal solvents (catalytic quantities).The use of sustainable methods has been beneficial to several fields of chemistry, including pharmaceuticals,fertilizers, catalysis, organic synthesis, preparation of medicinal solid forms, and synthesis of metal complexes.Pharmaceutical and pharmaceutical chemistry will likely be significantly impacted by these developments inmedicinal mechanochemistry. Due to their reactivity and materials, they provide materials that are hard to extractfrom a solution or are not possible. Nevertheless, these technologies could provide the pharmaceutical sectorwith safer, cleaner, and more effective synthetic solutions. The importance of mechanochemical processes in thecreation of pharmaceutical cocrystals, especially non-steroidal anti-inflammatory drugs (NSAIDs), is discussed inthis article.

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14

Nerkar, Amit Gajanan. "Pharmaceutical organic chemistry: Actual teaching aesthetics." Current Trends in Pharmacy and Pharmaceutical Chemistry 5, no. 1 (April 15, 2023): 1–3. http://dx.doi.org/10.18231/j.ctppc.2023.001.

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The most difficult subject for students of Pharmacy or Pharmaceutical Sciences undergraduates and postgraduates is Pharmaceutical Organic Chemistry. The professor teaching this subject should be well versed with basic concepts of the Organic Chemistry belonging to the specialization of Chemical Sciences. The Pharmaceutical Organic Chemistry specialization has vast scope, and the teaching professor needs to clear the basics concepts of the subject. In this connection the actual teaching aesthetics of Pharmaceutical Organic Chemistry (POC) has been described. The review is an attempt to summarize the importance of the POC and make aware the teachers of Indian and Foreign Universities for the new direction and aesthetics of the teaching of the same.

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15

Salomon, Claudio. "Macromolecules Applied to Pharmaceutical Chemistry." Molecules 10, no. 1 (January 31, 2005): 3–5. http://dx.doi.org/10.3390/10010003.

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16

Kumar, M. N. V. Ravi, R. A. A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A. J. Domb. "Chitosan Chemistry and Pharmaceutical Perspectives." Chemical Reviews 104, no. 12 (December 2004): 6017–84. http://dx.doi.org/10.1021/cr030441b.

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17

Tucker, John L. "Green Chemistry, a Pharmaceutical Perspective." Organic Process Research & Development 10, no. 2 (March 2006): 315–19. http://dx.doi.org/10.1021/op050227k.

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18

Rizak, Galina. "THE USE OF CALCULATION PROBLEMS IN THE TEACHING OF PHARMACEUTICAL CHEMISTRY." Continuing Professional Education: Theory and Practice 74, no. 1 (2023): 68–75. http://dx.doi.org/10.28925/1609-8595.2023.1.6.

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The training of specialists in the field of pharmacy is an urgent issue for a developed, social and legal state. Ukraine is no exception, in the educational policy of which a special place is given to pharmaceuticals. The purpose of the work concerned the definition of qualitative methods of teaching pharmaceutical chemistry, in particular, based on the use of calculation problems during practical classes. The research used the methods of analysis, synthesis, comparison and generalization. The experimental and scientific base of the research is the Uzhhorod National University. The developed provisions were tested on students pursuing higher education in the specialty «Pharmacy, industrial pharmacy» of the Faculty of Medicine. It was revealed which of the tasks should be performed by students in the course of their individual activities, for example during independent work, as well as within classroom classes. Various approaches to the organization of the educational process, namely teaching of pharmaceutical chemistry, were characterized. In addition, the content of the above-mentioned academic discipline was considered and its priority for pharmacy students was determined. Also, the main types and directions of calculation problems related to pharmaceutical chemistry were characterized. So, the influence of this type of tasks on the level of knowledge and professional training of students, as well as the possibility of implementing the latter's acquired skills in practical activities, is revealed. The obtained conclusions can be effectively used both by teachers, during preparation for classes with students of higher pharmaceutical education studying pharmacy, and directly by students for independent development.

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19

Das, Ananya, Abir Sadhukhan, Soumallya Chakraborty, Somenath Bhattacharya, Dr Amitava Roy, and Dr Arin Bhattacharjee. "Role of Green Chemistry in Organic Synthesis and Protection of Environment." International Journal for Research in Applied Science and Engineering Technology 10, no. 12 (December 31, 2022): 1850–53. http://dx.doi.org/10.22214/ijraset.2022.48373.

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Abstract: Nowadays green chemistry plays a vital role in organic chemistry. It minimizes the effect and use of hazardous substances on the environment and human health. The main goal of green chemistry is to use of green solvents (PEG, water, acetone, alcohol) eliminate the toxicity, uses of small quantity of catalyst and minimize the potential for chemical accident during work. Green chemistry is one type of chemistry where main focus is to eliminate or minimize the hazards by applying suitable process and raw materials. So it is more effective to pharmacists or chemists for avoiding this bad impact on human health, environment. Green chemistry also known as sustainable chemistry. Green chemistry is always interesting matter to pharmacists as well as chemists for synthesis pharmaceutical products. Green chemistry brings a new path for synthesizing safer chemical products. For manufacturing pharmaceutical products by using green chemistry, there have many criteria or methods that should be followed for synthesis chemical products during manufacturing condition. Some of these are prevention waste, Atom economy, less hazardous chemical syntheses, designing safer chemicals, safer solvents, design for more energy efficient chemical, use of renewable feed stocks, reduce derivatives in any compounds, catalysis, design for degradation, real time analysis for pollution prevention, inherently safer for accident prevention, etc. These methods should be considerable before synthesized chemical products by applying green chemistry for eliminating or minimizing hazardous in chemical products during synthesis.

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20

Tong, Alfred, Rhiannon Braund, David Warren, and Barrie Peake. "TiO2-assisted photodegradation of pharmaceuticals — a review." Open Chemistry 10, no. 4 (August 1, 2012): 989–1027. http://dx.doi.org/10.2478/s11532-012-0049-7.

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AbstractPharmaceutical compounds have been detected in the environment and potentially arise from the discharge of excreted and improperly disposed medication from sewage treatment facilities. In order to minimize environmental exposure of pharmaceutical residues, a potential technique to remove pharmaceuticals from water is the use of an advanced oxidation process (AOP) involving titanium dioxide (TiO2) photocatalysis. To evaluate the extent UV/TiO2 processes have been studied for pharmaceutical degradation, a literature search using the keywords ‘titanium dioxide’, ‘photocatalysis’, ‘advanced oxidation processes’, ‘pharmaceuticals’ and ‘degradation’ were used in the ISI Web of Knowledge TM, Scopus TM and ScienceDirect TM databases up to and including articles published on 23 November 2011. The degradation rates of pharmaceuticals under UV/TiO2 treatment were dependent on type and amount of TiO2 loading, pharmaceutical concentration, the presence of electron acceptors and pH. Complete mineralization under particular experimental conditions were reported for some pharmaceuticals; however, some experiments reported evolution of toxic intermediates during the photocatalytic process. It is concluded that the UV/TiO2 system is potentially a feasible wastewater treatment process, but careful consideration of the treatment time, the loading and the type of TiO2 (doped vs. undoped) used for a particular pharmaceutical is necessary for a successful application (198 words).

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21

Zacharis, Constantinos K., and Catherine K. Markopoulou. "Recent Trends in Pharmaceutical Analytical Chemistry." Molecules 25, no. 16 (August 5, 2020): 3560. http://dx.doi.org/10.3390/molecules25163560.

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22

Xia, Wandong. "The Experimental Teaching Reform and Exploration of Pharmaceutical Chemistry in Biopharmaceutical Major." Advances in Higher Education 3, no. 4 (December 19, 2019): 150. http://dx.doi.org/10.18686/ahe.v3i4.1534.

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<p>Pharmaceutical chemistry is an important course in biopharmaceutical major. The subject knowledge permeates many subjects and has a strong theoretical and guiding function. However, there are still a lot of problems in the pharmaceutical chemistry experiment course and the development is not perfect, which needs to be timely reformed and innovated. This paper mainly discusses the reform of experimental teaching of pharmaceutical chemistry in biopharmaceutical major, analyzes the current situation of experimental teaching of pharmaceutical chemistry, finds out the problems and gives solutions, and proposes the corresponding reform measures. This paper explores active and effective teaching methods from the aspects of teaching modes, the laboratory, experimental materials and teaching methods, so as to improve the experimental teaching of pharmaceutical chemistry of biopharmaceutical major, improve the teaching quality and promote the cultivation of students' comprehensive ability.</p>

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23

Ferreira, Elizabeth Igne. "Chemistry and pharmaceutical sciences always together." Brazilian Journal of Pharmaceutical Sciences 46, no. 3 (September 2010): v. http://dx.doi.org/10.1590/s1984-82502010000300001.

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24

Folkers, Gerd. "Pharmaceutical Chemistry at the ETH Zürich." CHIMIA International Journal for Chemistry 58, no. 10 (October 1, 2004): 707–10. http://dx.doi.org/10.2533/000942904777677362.

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25

Westwell, Andrew D., David GE Caldicott, and Alun Hutchings. "The dark side of pharmaceutical chemistry." Future Medicinal Chemistry 4, no. 2 (February 2012): 129–32. http://dx.doi.org/10.4155/fmc.11.186.

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26

Van Hoey, Nicole Marie. "Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules." Annals of Pharmacotherapy 36 (October 2002): 1655–56. http://dx.doi.org/10.1345/aph.1c205.

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27

Kawaguchi, Mitsuyasu, and Atsuhiko Taniguchi. "Life-oriented Chemistry in Pharmaceutical Sciences." YAKUGAKU ZASSHI 139, no. 2 (February 1, 2019): 261–62. http://dx.doi.org/10.1248/yakushi.18-00174-f.

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28

Z, Gerd Folkers. "Pharmaceutical chemistry, does it still exist?" Pharmaceutica Acta Helvetiae 69, no. 2 (October 1994): 59. http://dx.doi.org/10.1016/0031-6865(94)90001-9.

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29

Reiser, Oliver. "Process chemistry in the pharmaceutical industry." European Journal of Pharmaceutics and Biopharmaceutics 50, no. 3 (November 2000): 420. http://dx.doi.org/10.1016/s0939-6411(00)00114-4.

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30

Templeton, W. "Pharmaceutical chemistry. Vol. 1: Drug synthesis." Endeavour 13, no. 1 (January 1989): 43. http://dx.doi.org/10.1016/0160-9327(89)90063-x.

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31

Davies, I. W., and C. J. Welch. "Looking Forward in Pharmaceutical Process Chemistry." Science 325, no. 5941 (August 6, 2009): 701–4. http://dx.doi.org/10.1126/science.1174501.

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32

Martin, Gary E., and David J. Detlefsen. "Guest Editorial: NMR in Pharmaceutical Chemistry." Magnetic Resonance in Chemistry 39, no. 9 (2001): 497. http://dx.doi.org/10.1002/mrc.915.

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33

Potrzebowski, Marek J. "ChemInform Abstract: Organic & Pharmaceutical Chemistry." ChemInform 42, no. 23 (May 12, 2011): no. http://dx.doi.org/10.1002/chin.201123234.

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34

Idris, Mark Steve. "Green chemistry approaches in pharmaceutical manufacturing." International Journal of Pharmacy and Pharmaceutical Science 1, no. 2 (January 1, 2019): 38–39. http://dx.doi.org/10.33545/26647222.2019.v1.i2a.100.

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35

Takale, Balaram S., Fan-Yi Kong, and Ruchita R. Thakore. "Recent Applications of Pd-Catalyzed Suzuki–Miyaura and Buchwald–Hartwig Couplings in Pharmaceutical Process Chemistry." Organics 3, no. 1 (January 18, 2022): 1–21. http://dx.doi.org/10.3390/org3010001.

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Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination reactions have given opportunities to elegantly make pharmaceutical ingredients. Indeed, these reactions are at the forefront of both the stages of drug development, medicinal chemistry, and process chemistry. On the one hand, these reactions have given medicinal chemists a resource to derivatize the core compound to arrive at scaffold rapidly. On the other hand, these cross couplings have offered the process chemists a smart tool to synthesize the development candidates safely, quickly, and efficiently. Generally, the application of cross-coupling reactions is broad. This review will specifically focus on their real (pharma) world applications in large-scale synthesis appearing in the last three years.

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36

Zawodny, Wojciech, and Sarah Louise Montgomery. "Evolving New Chemistry: Biocatalysis for the Synthesis of Amine-Containing Pharmaceuticals." Catalysts 12, no. 6 (May 30, 2022): 595. http://dx.doi.org/10.3390/catal12060595.

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Biocatalysis has become an attractive tool in modern synthetic chemistry both in academic and industrial settings, offering access to enantiopure molecules. In industry, biocatalysis found use in small molecule pharmaceutical development. For several amine-containing drugs, biotransformations were applied in the process routes, improving the original syntheses employing classical chemical methods. This review illustrates how and why biocatalysis has been applied to create safer, more efficient and less costly processes for the manufacture of chiral amine-containing pharmaceuticals and alkaloids. Several enzyme classes have been applied to syntheses of natural products, pharmaceutical products and their intermediates, including transaminases, imine reductases, monoamine oxidases and Pictet-Spenglerases. The routes with and without application of biocatalysis are compared, and the potential of these enzyme classes in redesigned synthetic routes to natural products, alkaloids and high-value chemicals is evaluated, using syntheses of sitagliptin, suvorexant, PF-04449913, MK-7246, vernakalant, GSK-2879552, boceprevir and (−)-strictosidine as examples. Application of biocatalysis in the synthesis of amine-containing pharmaceuticals constitutes a greener alternative to transition metal-catalysed routes, facilitates installation of chiral amine functionalities at a late stage of the synthesis and provides exquisite stereocontrol. Opportunities and challenges of biocatalysis for the synthesis of chiral amines are reviewed with respect to use in drug discovery and development.

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37

M Singh, Ripudaman, Riya Pramanik, and Subhajit Hazra. "Role of green chemistry in pharmaceutical industry: a review." Journal of University of Shanghai for Science and Technology 23, no. 12 (December 16, 2021): 291–99. http://dx.doi.org/10.51201/jusst/21/121018.

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Sustainability is the ability to nurture or support a process for an extended period without compromising the needs of the future generation. Sustainable chemistry is a term that refers to the creation of chemical products and processes that decreases or remove the use and production of hazardous substances. Even though sustainable and green technologies have evolved in other scientific fields, their use in the pharmaceutical industry is still initial stage. Therefore, we need to work in green chemistry to ensure its growth in the pharmaceutical industry. Thus, the current review aimed to highlight the need for green chemistry or sustainable chemistry and its principles and its application in the pharmaceutical industry to practice environment-friendly production of pharmaceutical products and reduce or stop the production of harmful intermediates and products during the synthesis process.

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38

Lukaschuk, Tatyana. "Features of teaching analytical chemistry to pharmaceutical students." Journal of Pedagogical Studies 9, no. 1 (April 23, 2024): 150–56. http://dx.doi.org/10.12737/2500-3305-2024-9-1-150-156.

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The article reveals some features of teaching analytical chemistry as one of the main subjects for training future pharmacists. It is shown that the course of analytical chemistry forms the basic practical skills necessary in subsequent professional activity. The difficulties of teaching analytical chemistry associated with time constraints and a large volume of material that is submitted for consideration at the lecture are noted. This requires a very clear structure and sequence from the teacher, as well as multimedia accompaniment, which contributes to a better perception of the material presented and its assimilation. It is necessary that each practical lesson be provided with methodological recommendations, materials for preparing for a practical lesson, tests for knowledge control, situational tasks, as well as methodological recommendations for independent work of students. Special attention is paid to the importance of solving computational problems, which is an integral part of the practical lesson. This allows you to better understand the basic methods and techniques of chemical analysis, as well as acquire comprehensive chemical knowledge necessary for the successful study of professional disciplines. Assimilation of knowledge in analytical chemistry is a necessary step in preparing students for the conscious perception of specialized disciplines – pharmaceutical chemistry, technology, pharmacology, pharmacognosy, toxicological chemistry.

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39

Zhang, Hui, Qian Yun Zhang, and Hui Quan Jing. "Application for the Method of PBL in Pharmaceutical Chemistry Teaching." Advanced Materials Research 271-273 (July 2011): 1670–73. http://dx.doi.org/10.4028/www.scientific.net/amr.271-273.1670.

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To assess the effectiveness of assisted problem-based learning (PBL) compared to a didactic approach in a pharmaceutics course. The comparison was performed among 215 in a 3-year pharmacy program. They were divided into 2 groups, each consisting of about 107 students. The control group was identified as the ‘traditional teaching’ group and studied pharmaceutical chemistry under a didactic model. The experimental group was identified as the ‘PBL teaching’ group and studied similar object under accomplished learning model. At the end of the experiment, there was a questionnaire answered by the students to write their opinions on PBL teaching. The scores of the students in the final examination and the results of the questionnaire were statistically evaluated through SPSS 13.0. PBL students scored significantly higher on the final examinations than the traditional class students. Moreover, the results to the questionnaire show that students are more willing to learn through PBL. Introducing PBL into pharmaceutics improves educational quality and effectiveness. Digital PBL cases stimulate interest in self-learning and motivate students to learn by themselves.

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40

Quintero-Álvarez, Fátima Gisela, Cintia Karina Rojas-Mayorga, Didilia Ileana Mendoza-Castillo, Ismael Alejandro Aguayo-Villarreal, and Adrián Bonilla-Petriciolet. "Physicochemical Modeling of the Adsorption of Pharmaceuticals on MIL-100-Fe and MIL-101-Fe MOFs." Adsorption Science & Technology 2022 (March 8, 2022): 1–14. http://dx.doi.org/10.1155/2022/4482263.

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The adsorption of naproxen (NAP), diclofenac (DFC), and acetaminophen (APAP) molecules from aqueous solutions using MIL-100-Fe and MIL-101-Fe metal organic frameworks (MOFs) has been analyzed and modeled. Adsorption isotherms of these pharmaceuticals were experimentally quantified at 30 and 40°C and pH 7. Textural parameters and surface chemistry of these MOFs were analyzed, and results were utilized to explain the pharmaceutical adsorption mechanism. Density Functional Theory (DFT) calculations were performed to understand the reactivity of pharmaceutical molecules, and a statistical physics model was employed to calculate the main physicochemical parameters related to the adsorption mechanism. Results showed that the adsorption of these pharmaceuticals on MOFs was multimolecular and exothermic. Both MOFs displayed the highest adsorption capacities, up to 2.19 and 1.71 mmol/g, for NAP and DFC molecules, respectively. MIL-101-Fe showed better pharmaceutical adsorption properties than MIL-100-Fe due to its highest content of Fe-O clusters and mesopore volume. Adsorption mechanism of these organic molecules could involve hydrogen bond, van der Waals forces, and electrostatic interactions with MOF surfaces. In particular, MIL-101-Fe MOF is a promising material to prepare composites with competitive adsorption capacities for facing the water pollution caused by pharmaceutical compounds.

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Rahman, Habibur. "Analytical Applications of Permanganate as an Oxidant in the Determination of Pharmaceuticals Using Chemiluminescence and Spectrophotometry: A Review." Current Analytical Chemistry 16, no. 6 (August 13, 2020): 670–86. http://dx.doi.org/10.2174/1573411015666190617103833.

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Background: Potassium permanganate is a green and versatile industrial oxidizing agent. Due to its high oxidizing ability, it has received considerable attention and has been extensively used for many years for the synthesis, identification, and determination of inorganic and organic compounds. Objective: Potassium permanganate is one of the most applicable oxidants, which has been applied in a number of processes in several industries. Furthermore, it has been widely used in analytical pharmacy to develop analytical methods for pharmaceutically active compounds using chemiluminescence and spectrophotometric techniques. Results: This review covers the importance of potassium permanganate over other common oxidants used in pharmaceuticals and reported its extensive use and analytical applications using direct, indirect and kinetic spectrophotometric methods in different pharmaceutical formulations and biological samples. Chemiluminescent applications of potassium permanganate in the analyses of pharmaceuticals using flow and sequential injection techniques are also discussed. Conclusion: This review summarizes the extensive use of potassium permanganate as a chromogenic and chemiluminescent reagent in the analyses of pharmaceutically active compounds to develop spectrophotometric and chemiluminescence methods since 2000.

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Tang, Pei, Biao Nie, Jiuzhong Huang, Yingjun Zhang, Ji Zhang, and Fen-er Chen. "Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1." Pharmaceutical Fronts 02, no. 01 (March 2020): e28-e54. http://dx.doi.org/10.1055/s-0040-1701652.

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AbstractThis review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the-counter medicine biotin, demonstrating China's substantial effort to green its pharmaceutical processes. Owing to the increasing stringent environmental regulations, Chinese chemists have invented several cutting-edge and eco-friendly synthetic methods that are beneficial to environmental protection. Applied to large-scale industrial production, these processes have a greatly reduced environmental footprint, promoting the sustainable development of global economy and health.

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Dembitsky, Valery M. "Steroids Bearing Heteroatom as Potential Drugs for Medicine." Biomedicines 11, no. 10 (October 3, 2023): 2698. http://dx.doi.org/10.3390/biomedicines11102698.

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Heteroatom steroids, a diverse class of organic compounds, have attracted significant attention in the field of medicinal chemistry and drug discovery. The biological profiles of heteroatom steroids are of considerable interest to chemists, biologists, pharmacologists, and the pharmaceutical industry. These compounds have shown promise as potential therapeutic agents in the treatment of various diseases, such as cancer, infectious diseases, cardiovascular disorders, and neurodegenerative conditions. Moreover, the incorporation of heteroatoms has led to the development of targeted drug delivery systems, prodrugs, and other innovative pharmaceutical approaches. Heteroatom steroids represent a fascinating area of research, bridging the fields of organic chemistry, medicinal chemistry, and pharmacology. The exploration of their chemical diversity and biological activities holds promise for the discovery of novel drug candidates and the development of more effective and targeted treatments.

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Chu, Hongbiao. "How to Cultivate Students’ Innovation Ability in the Teaching of Natural Pharmaceutical Chemistry." Research and Advances in Education 1, no. 4 (October 2022): 28–31. http://dx.doi.org/10.56397/rae.2022.10.05.

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The goal of education is to cultivate students’ innovative spirit, innovative thinking and innovative ability. Natural pharmaceutical chemistry is a required course for pharmacy majors, and plays an important role in the pharmaceutical courses. In order to meet the requirements of the society for innovative talents in pharmacy, this project, based on the teaching characteristics of the course “Natural Pharmaceutical Chemistry”, combined with scientific research, explored and studied the teaching of natural pharmaceutical chemistry, and explored the ways and specific methods to cultivate students’ innovation ability from the aspects of theoretical teaching, experimental teaching, graduation practice and undergraduate thesis design. The improvement of students’ innovation ability plays an important role in promoting teaching work, improving teaching quality and students’ employment level. With the deepening of the reform of higher education, we will also continue to explore new ideas, new ways and new measures that are conducive to pharmaceutical education, so that the teaching level of natural pharmaceutical chemistry will continue to improve and students’ innovation ability will continue to strengthen.

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Debue-Barazer, Christine. "Les implications scientifiques et industrielles du succès de la Stovaïne®. Ernest Fourneau (1872–1949) et la chimie des médicaments en France." Gesnerus 64, no. 1-2 (November 11, 2007): 24–53. http://dx.doi.org/10.1163/22977953-0640102002.

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The synthetic local anaesthetic Stovaïne® was commercialised in France in 1904. Its inventor, Ernest Fourneau, began his career as a pharmaceutical chemist in organic chemistry laboratories in Germany, where from 1899 to 1901 he discovered how basic research could benefit from the modern chemistry theories which had developed in Germany starting in the 1860s. Using the complex structure of cocaine, he invented an original molecule, with comparable activity, but less toxic. The knowledge and the know-how which he acquired in Germany nourished his reflection in the field of the chemistry of the relationships between structure and activity, and led him to the development of Stovaïne®. Emile Roux, Director of the Pasteur Institute in Paris,was interested in his work and invited him to head the first French therapeutic chemistry laboratory, in which research on medicinal chemistry was organised scientifically. The industrial development of new medicines resulting from the Pasteur Institute’s therapeutic chemistry laboratory was supported by the Etablissements Poulenc frères, France thus gaining international reputation in the domain of pharmaceutical chemistry.

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Steven, Alan. "Micelle-Mediated Chemistry in Water for the Synthesis of Drug Candidates." Synthesis 51, no. 13 (May 21, 2019): 2632–47. http://dx.doi.org/10.1055/s-0037-1610714.

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Micellar reaction conditions, in a predominantly aqueous medium, have been developed for transformations commonly used by synthetic chemists working in the pharmaceutical industry to discover and develop drug candidates. The reactions covered in this review are the Suzuki–Miyaura, Miyaura borylation, Sonogashira coupling, transition-metal-catalysed CAr–N coupling, SNAr, amidation, and nitro reduction. Pharmaceutically relevant examples of these applications will be used to show how micellar conditions can offer advantages in yield, operational ease, amount of waste generated, transition-metal catalyst loading, and safety over the use of organic solvents, irrespective of the setting in which they are used.1 Introduction2 Micelles as Solubilising Agents3 Micelles as Nanoreactors4 Designer Surfactants5 A Critical Evaluation of the Case for Chemistry in Micelles6 Scope of Review7 Suzuki–Miyaura Coupling8 Miyaura Borylation9 Sonogashira Coupling10 Transition-Metal-Catalysed CAr–N Couplings11 SNAr12 Amidation13 Nitro Reduction14 Micellar Sequences15 Summary and Outlook

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Shinkevich, A. I., L. R. Mukhamatgaleeva, and V. I. Bobkov. "THE ROLE OF THE INTRODUCTION OF DIGITAL PRODUCTION SYSTEMS IN A PHARMACEUTICAL ENTERPRISE." Izvestiya of Samara Scientific Center of the Russian Academy of Sciences 23, no. 6 (2021): 62–66. http://dx.doi.org/10.37313/1990-5378-2021-23-6-62-66.

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Due to the growing global crisis against the background of the COVID-19 pandemic, the issue of uninterrupted provision of medicines to the population has become critically important. In this regard, the introduction of information management systems at pharmaceutical enterprises is becoming particularly relevant. The pharmaceutical industry as a whole faces a number of unique challenges, including close regulatory oversight, sophisticated testing methods, and growing financial pressures as competition in the market increases. Industry leaders are digitizing core functions within their internal vertical operational processes, as well as with their value chain partners. One of the information management systems in the laboratory is the LIMS (Laboratory information system) information system. One of the challenges when choosing LIMS in pharmaceuticals is the variety of laboratories in the company - combinatorial chemistry, screening, preclinical and clinical bioanalysis, analytical chemistry, industrial R&D and production quality control, requiring unique needs and workflows. With the development of business, information technology and the regulatory framework, the role of LIMS in the pharmaceutical organization is also increasing. Proper implementation of this mechanism in the work of a pharmaceutical enterprise will help to preserve the quality of the product, reduce and optimize the work and satisfy the end user and government agencies.

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Kalia, Yogeshvar N., Remo Perozzo, and Leonardo Scapozza. "The Pharmaceutical Biochemistry Group: Where Pharmaceutical Chemistry Meets Biology and Drug Delivery." CHIMIA International Journal for Chemistry 66, no. 5 (May 30, 2012): 313–19. http://dx.doi.org/10.2533/chimia.2012.313.

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Iohara, Daisuke, and Taishi Higashi. "Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry." YAKUGAKU ZASSHI 139, no. 2 (February 1, 2019): 141–42. http://dx.doi.org/10.1248/yakushi.18-00168-f.

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Rajput, Dr Gurinder Singh. "Editorial." Asian Journal of Chemistry and Pharmaceutical Sciences 2, no. 1 (April 17, 2017): i. http://dx.doi.org/10.18311/ajcps/2017/15908.

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I am pleased to present the Volume 2 Issue 1 of Asian Journal of Chemistry and Pharmaceutical Sciences. AJCPS is a quarterly peer-reviewed journal committed to publish the high quality articles in all area of chemistry and pharmaceutical science. Chemistry and Pharmaceutical science are closely related disciplines and their convergence is very frequent. In spite of excessive ongoing research in these disciplines very few journals, especially from Asian region are available those cover both the subjects. I hope that AJCPS will encourage the researchers, students and academicians involved in Chemistry and Pharmaceutical research.

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