Log in

Relevant bibliographies by topics / Phage library / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Phage library.

Dissertations / Theses on the topic 'Phage library'

Author: Grafiati

Published: 1 April 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Phage library.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Bell, Matthew John. "Phage display of a cDNA library from Arabidopsis thaliana." Thesis, Coventry University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393652.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Keklikian, Artine. "Construction of a Synthetic Human VL Phage Display Library and Isolation of Potential Neuropilin-1-specific VL Therapeutics from the Library." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20197.

Full text

Abstract:

Antibody phage display technology mimics the natural immune system, and has been widely used for rapid isolation of single-domain antibodies (sdAbs) with various binding specificities and affinities in the micromolar to low nanomolar range. SdAbs are the variable regions of immunoglobulins (e.g., VH, VL, VHH) and serve as potential probes with therapeutic value. The small size, high solubility, high expression and stability, and high specificity and affinity for the cognate antigen, make sdAbs ideal in improving drug delivery and the overall therapeutic value of antibodies. The main objecti

APA, Harvard, Vancouver, ISO, and other styles

3

Clayton, Ruth. "Generation and characterisation of human sperm antibodies by combinatorial phage display library technology." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286988.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Hald, Rikke. "Generation and characterisation of a naive human antibody phage display library : a resource for clinically relevant reagents /." Cph. : Department of Pharmacology, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/rikkehald.htm.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Prendergast, D. "Discovery of tumour necrosis factor receptor-1 (p55) binding peptides using a phage display library." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368468.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Saxena, Abhishek. "Construction of immune scFv M13 phage display library and isolation of anti-glycan monoclonal antibodies." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203295.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Lim, Theam Soon [Verfasser]. "Parameters affecting phage display library design for improved generation of human antibodies / Theam Soon Lim." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023748355/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Cortini, Andrea. "Serum profiling and autoantibodies identification in Multiple Sclerosis using epitope and CSF IgG phage display libraries." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3073.

Full text

Abstract:

2007/2008<br>Multiple sclerosis (MS) is considered the prototype of inflammatory autoimmune diseases of the central nervous system (CNS). The typical feature of the disease is the plaques of demyelination. The evolution of the plaque lesion in MS implicates an inflammatory phase followed by a recovery of functional myelin; a second step is the chronic progressive disease with axonal loss. The earlier phase of MS may be mediated by an autoimmune reaction. Whereas the role of T cells in MS pathogenesis is well established, the role of B cells and autoantibodies in demyelination and plaque for

APA, Harvard, Vancouver, ISO, and other styles

9

Bosompem, Amma N. "Isolation of an anti-CD20 single chain variable fragment from a naïve human phage-scFv library." Connect to this title online, 2007. http://etd.lib.clemson.edu/documents/1202410076/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Marson, Lorena. "Phage-display epitope library development for biomarkers identification in autoimmune diseases of the Central Nervous System." Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7405.

Full text

Abstract:

2010/2011<br>The principal aim of my PhD was the setting of a protocol for the creation of phage libraries to display cDNA fragments encoding real ORF sequences, that could correspond to potential epitopes. A similar phage display library contains all the potential ORF repertoire of a cell or tissue. This tool can be specially used in the study of autoimmune diseases to perform different kind of analysis, such as the identification of epitopes involved in pathological reaction, the comparison between healthy and pathological conditions, or between different pathological conditions. A complex p

APA, Harvard, Vancouver, ISO, and other styles

11

Abi, Ghanem Daad Ali. "Phage display selection of recombinant antibodies derived from a chicken immune library against cryopreserved Eimeria tenella sporozoites." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1847.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Sorsa-Leslie, Tarja. "Combining phage display antibody library and bioassay technologies to identify candidate gonadotropin surge attenuating factor (GnSAF) molecules." Thesis, University of Aberdeen, 2005. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU212837.

Full text

Abstract:

The aim of this thesis was to generate "artificial" antibodies against a bioactive protein, GnSAF, produced by human ovarian granulosa cells that remains unidentified after 20 years of research. The library used in this study was a synthetic single-chain antibody scFv, Tomlinson J library. The antigen for biopanning was partially purified GnSAF. Screening the antibody clones from the library incorporated an additional selection step: an in vitro rat monolayer bioassay for GnSAF based on the specific suppression of GnRH-induced LH secretion. The initial screening with a binding ELISA technique

APA, Harvard, Vancouver, ISO, and other styles

13

Nguyen, Hai Phu. "Combination of hu-PBL-SCID mice and scFv phage display library, an effective alternative for hu-mAb production." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58617.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Fehrsen, Jeanni. "Isolation of antigenic peptides of Cowdria ruminantium and their encoding genes using a genome-derived phage display library." Thesis, Rhodes University, 2003. http://hdl.handle.net/10962/d1003979.

Full text

Abstract:

The development of new and effective vaccines and immunodiagnostic reagents requires the characterisation of antigenically relevant proteins and their interactions with the products of the immune system. Phage display technology was investigated as a means of elucidating some of the antigenic properties of the rickettsial parasite, Cowdria ruminantium (Cowdria). Randomly fragmented gene-derived libraries have been useful in elucidating viral and other epitopes, but only limited work has been done with entire genomes. A phage display library expressing a repertoire of Cowdria peptides was const

APA, Harvard, Vancouver, ISO, and other styles

15

Bessa, Juliana Mattos de Almeida. ""Determinação de alvos antigênicos na doença reumática cardíaca utilizando phage display"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-12042006-164408/.

Full text

Abstract:

Pacientes com doença reumática cardíaca (DRC) desenvolvem lesões valvares mediadas por linfócitos T CD4+, capazes de reconhecer cruzadamente proteínas cardíacas e estreptocócicas pelo mecanismo de mimetismo molecular. Neste trabalho empregamos uma biblioteca peptídica de Phage Display para identificar auto-antígenos cardíacos capazes de serem reconhecidos por duas linhagens intralesionais de linfócitos T e um clone derivado de uma das linhagens isolados de pacientes com DRC. A análise dos peptídeos dos fagos em banco de dados de proteínas revelou novos epitopos da miosina cardíaca, laminina, v

APA, Harvard, Vancouver, ISO, and other styles

16

Igloi, Zsofia. "Identifying novel interaction partners for the hepatitis C virus NS5A protein by screening a human SH3 domain phage display library." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574514.

Full text

Abstract:

The hepatitis C virus is a worldwide cause of liver disease by infecting approximately 2 % of the population. One of its non-structural protein, NS5A, Is known to interact with many cellular proteins involved in cell signaling pathways. Doing so modifies the outcome of the signalling for the benefit of virus replication and survival. We have previously demonstrated that NSSA contains two Class II poly-proline motifs in the second low complexity sequence, with the consensus sequence Pro-X-X-Pro-X-Lys/ Arg, which mediate the interaction with SH3 domain containing proteins. Substitution of the pr

APA, Harvard, Vancouver, ISO, and other styles

17

Caucheteur, Déborah. "Nouveau format de banques d’anticorps recombinants humains pour un criblage fonctionnel à grande échelle." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT012.

Full text

Abstract:

Les anticorps monoclonaux (mAb) sont depuis les années 2000 devenus des médicaments incontournables et de routine en thérapie et notamment en cancérologie. Le domaine continue à croître très rapidement et devant l’abondance des molécules disponibles, il est de plus en plus important d’apporter des molécules innovantes à haute valeur ajoutée pour la thérapie. Deux grandes approches sont utilisées pour sélectionner ces mAbs : l’hybridation lymphocytaire à partir de souris normales ou humanisées ; Les systèmes de display comme le phage-display. Les intérêts majeurs du phage display sont la rapidi

APA, Harvard, Vancouver, ISO, and other styles

18

Ndlovu, Siphumelele. "The isolation of single chain variable region fragments (scFvs) from a phage display library, and expression of the isolated scFvs in Nicotiana benthamiana." Master's thesis, Faculty of Science, 2020. http://hdl.handle.net/11427/32303.

Full text

Abstract:

Monoclonal antibodies (mAbs) are an important tool for both therapeutic and nontherapeutic applications. Their increased demand is due to their ability to recognize and bind specifically to a wide range of antigens. In addition to full-size antibodies, one can also utilise smaller antibody fragments, single chain variable region fragments (scFvs), which like full-size mAbs, are also capable of specific antigen-binding. The constant and rapidly expanding use of antibodies and their derivatives presents a need for a fast and effective method of production. Traditionally, antibodies have been pro

APA, Harvard, Vancouver, ISO, and other styles

19

Bandmann, Nina. "Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification." Doctoral thesis, Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4318.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Hubert, Ágnes [Verfasser], Wolfgang [Akademischer Betreuer] Baumeister, and Sevil [Akademischer Betreuer] Weinkauf. "Needle in the haystack: Protein complex purification from Thermoplasma acidophilum with a phage display library / Ágnes Hubert. Gutachter: Sevil Weinkauf ; Wolfgang Baumeister. Betreuer: Wolfgang Baumeister." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/103576671X/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Mundin, Georgia Sabio Porto. "Identificação de marcadores moleculares para células T reguladoras humanas com perfil CD4+CD25+ por phage display." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-28012009-131608/.

Full text

Abstract:

Há dados na literatura indicando que as células que saem do timo com o fenótipo CD4+CD25+ são desenvolvidas continuamente como uma linhagem independente e possuem um papel importante no processo de regulação da resposta imune. Essas células são chamadas células T reguladoras naturais. Várias questões sobre estas células permanecem em aberto, como por exemplo, como elas são geradas, o que é determinante na sua atividade reguladora e que marcadores específicos podem ser usados para identificá-las? Dentro deste contexto, o nosso objetivo neste trabalho foi identificar no timo e em timócitos CD4+/

APA, Harvard, Vancouver, ISO, and other styles

22

Sulaiman, Lanre Precieux Kabir. "Seleção de motivos semelhantes a Papilomavírus, a partir de bibliotecas de phage display, que apresentem potencial aplicação translacional." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-29012018-133017/.

Full text

Abstract:

O vínculo entre papilomavírus humano de alto risco e câncer cervical está bem estabelecido. Apesar da existência de vacinas profiláticas contra infecções pelos tipos mais comuns de HPV, para infecções e tumores causados por esses vírus as alternativas terapêuticas são restritas. Encontramos alguns motivos com homologias para proteínas do HPV de alto risco durante o imunoscreening de uma biblioteca de phage display com soros de participantes HPV-16-soropositivos da coorte Ludwig-McGill. Após enriquecimento das sequências, os bacteriófagos recombinantes foram purificados e amplificados para uso

APA, Harvard, Vancouver, ISO, and other styles

23

Zou, Jun. "Characterization of peptides and phage that bind galectin-3 selected from bacteriophage display libraries a study of the role of galectin-3 in metastasis-associated cancer cell adhesion /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4149.

Full text

Abstract:

Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>"December 2005" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

24

Bernedo-Navarro, Robert Alvin 1975. "Obtenção de peptídeos com capacidade inibitória da ação citotoxigênica das toxinas Stx de Escherichia colia partir de bibliotecas de phage display." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314705.

Full text

Abstract:

Orientador: Tomomasa Yano<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T11:52:53Z (GMT). No. of bitstreams: 1 Bernedo-Navarro_RobertAlvin_D.pdf: 2646572 bytes, checksum: 02b50bc28d5be6cddb78abfe621a047c (MD5) Previous issue date: 2013<br>Resumo: Escherichia coli produtora de toxina de Shiga (STEC) é um grupo de importantes patógenos para humanos. Essas bactérias são relacionadas a várias doenças, como por exemplo, Síndrome Urêmica Hemolítica e produzem potentes toxinas denominadas toxinas de Shiga. Essas toxinas, tant

APA, Harvard, Vancouver, ISO, and other styles

25

Lehtiö, Janne. "Functional studies and engineering of family 1 carbohydrate-binding modules." Doctoral thesis, KTH, Biotechnology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3211.

Full text

Abstract:

<p>The family 1 cellulose-binding modules (CBM1) form a groupof small, stable carbohydrate-binding proteins. These modulesare essential for fungal cellulosedegradation. This thesisdescribes both functional studies of the CBM1s as well asprotein engineering of the modules for several objectives.</p><p>The characteristics and specificity of CBM1s from the<i>Trichoderma reesei</i>Cel7A and Cel6A, along with severalother wild type and mutated CBMs, were studied using bindingexperiments and transmission electron microscopy (TEM). Datafrom the binding studies confirmed that the presence of onetrypto

APA, Harvard, Vancouver, ISO, and other styles

26

Grimm, Sebastian. "Ribosome display for selection and evolution of affibody molecules." Doctoral thesis, KTH, Molekylär Bioteknologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33191.

Full text

Abstract:

Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. In a first study, ribosome display was for the first time applied to the selection of so-called affibody molecules, including the design of a ribosome display gene cassette, initial test enrichment experiments and the selection of binders against murine IgG1. One of the selected binders (

APA, Harvard, Vancouver, ISO, and other styles

27

Shahsavarian, Melody. "Genesis of immune diversity and selection of catalytic antibodies : a new investigation." Thesis, Compiègne, 2015. http://www.theses.fr/2015COMP2215/document.

Full text

Abstract:

Les anticorps catalytiques (ou abzyme) ont fait l’objet de nombreuses recherches et ont été produits pour réaliser de nombreuses réactions. Ces protéines ont été ensuite découvertes dans le sérum d’individus sains ou atteints de pathologies, dont les pathologies autoimmunes. Les études suggèrent que ces abzymes peuvent avoir des effets bénéfiques ou délétères sur la santé des individus. L’origine des anticorps catalytiques et leur rôle restent ambigus et doivent être approfondis. Nous avons développé une nouvelle stratégie visant à étudier les abzymes, basée sur la technologie du phage display

APA, Harvard, Vancouver, ISO, and other styles

28

Harris, Jasmine K. "Bioconjugation of aminated DNA as a method of rapid polymer library generation for Corona Phase Molecular Recognition." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119063.

Full text

Abstract:

Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 39).<br>An experimental study was performed to determine the effects on Corona Phase Molecular Recognition (CoMoRe) of bioconjugating a host of small molecules to DNA wrapped single-walled carbon nanotubes. In addition, the study observed the effects of the DNA sequence length on the subsequent effectiveness of the small molecules to alter the corona phase. The conjugation of small molecules was shown t

APA, Harvard, Vancouver, ISO, and other styles

29

Hwang, Sung Hee. "I. Combinatorial solid-phase synthesis of isoxasolinopyrroles. II. OBOC small molecule combinatorial library encoded by halogenated mass-tags /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Yamakawa, Tatsuya. "Screening of human cDNA library reveals two differentiation-related genes, HHEX and HLX, as promoters of early phase reprogramming toward pluripotency." Kyoto University, 2016. http://hdl.handle.net/2433/217142.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Ruda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Huang, Adela Ya-Ting. "Advancing dendrimer synthesis : solid-phase and self-assembly approach." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0146.

Full text

Abstract:

Les dendrimères sont très prometteurs du fait de leur structure unique et de leur multivalence. Cependant, leur synthèse souffre de problèmes de défauts de structure et de présence de produits secondaires très similaires. Des approches synthétiques alternatives sont donc fortement désirées. L'objectif de ma thèse consiste à explorer la synthèse sur support solide et l’approche d'autoassemblage pour la préparation de dendrimères.La première partie de ma thèse se concentre sur la synthèse de dendrimères en phase solide. Nous avons tout d'abord développé une méthode de synthèse pour les dendrimèr

APA, Harvard, Vancouver, ISO, and other styles

33

Chen, Xingguo Ronald. "Pin1 Catalytic and WW Domain Ligands." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/37824.

Full text

Abstract:

Pin1 is a peptidyl prolyl isomerase (PPIase) enzyme with two domains, the catalytic domain and the WW domain. Both domains specifically bind pSer/pThrâ Pro motifs. Pin1 plays an important role in regulating the cell cycle, and it is involved in many diseases, such as cancer, HIV-1, Alzheimerâ s disease, asthma, hepatitis B, and rheumatoid arthritis. Pin1 is a very promising target for new drug development. Three stereoisomers: (R,S)-, (S,R)- and (S,S)-Acâ pSerâ Î¨[(Z)CH=C]â Pipâ 2-(2-naphthyl)ethylamine were synthesized as inhibitors binding to the Pin1 catalytic domain. The (R,S)- and

APA, Harvard, Vancouver, ISO, and other styles

34

Nilsson, Jonas. "Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors." Doctoral thesis, Linköpings universitet, Organisk Kemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3943.

Full text

Abstract:

This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. The affinities for HCAII of the flexible, synthetic helix-loop-helix motif conjugated with a series of spacered inhibitors were measured by fluorescence spectroscopy and found in the best cases to be in the low nM range. Dissociation constants show considerable dependence on linker length and vary from 3000 nM for the shortest spacer to 40 nM for the longest with a mi

APA, Harvard, Vancouver, ISO, and other styles

35

Subramaniam, Raja. "Simplified Routines for Sample Preparation and Analysis of Chemical Warfare Agent Degradation Products." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54639.

Full text

Abstract:

The thesis describes the development of new and improved methods for analyzing degradation markers from organophosphorus Chemical Warfare Agents (CWAs). Paper I and II describes an innovative and significantly improved method for the enrichment, derivatization (trimethysilylation) and GC-MS analysis of a broad range of organophosphorus CWAs degradation markers, namely the alkylphosphonic acids and a zwitterionic compound. That was achieved using solid phase disc extraction in combination with solid phase derivatization. The new method overcomes most limitations observed with existing technique

APA, Harvard, Vancouver, ISO, and other styles

36

Aftab, Obaid. "Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology." Doctoral thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234565.

Full text

Abstract:

Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. These algorithms must have capacity to extract and process quantitative dynamic information about how the cell population is

APA, Harvard, Vancouver, ISO, and other styles

37

Leslie, Susan Elder. "An examination of the information behaviour of new entrepreneurs in the start-up phase of a business submitted to the School of Information Management, Victoria University of Wellington in partial fulfilment of the requirements for the degree of Master of Library and Information Studies /." ResearchArchive@Victoria e-Thesis, 2009. http://hdl.handle.net/10063/1271.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Joo, Sang Hoon. "Synthesis and screening of support-bound combinatorial cyclic peptide and free C-terminal peptide libraries." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195561420.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

LIN, MING-CHUN, and 林明君. "Ractopamine Detection Through Phage Display Peptide Library." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/48211792124612562148.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Chou, Ying-Hsiu, and 周盈秀. "Construction of human phage-displayed scFv library." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/13301253686668832243.

Full text

Abstract:

碩士<br>國立成功大學<br>醫學檢驗生物技術學系碩博士班<br>97<br>Antibodies are applied not only for diagnosis, but also in research and clinical treatments. In order to generate high-affinity monoclonal antibodies, three techniques have been developed including hybridoma engineering, transgenic mice and phage-displayed antibody libraries. Although the hybridoma technology is the major tool for monoclonal antibody production, it still has some problems. For example, the methodology cannot be curable directly in human disease. Hence, the phage antibody display system has become more attractive to scientists. We attempt

APA, Harvard, Vancouver, ISO, and other styles

41

Lin, Shu-Jian, and 林淑娟. "Construction of scFv Phage Display Library Against Diphenylamine." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/92251249392714967412.

Full text

Abstract:

碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>92<br>Diphenylamine is an antioxidant, having the skeleton structure of non-steroidal anti-inflammatory drugs. In the use of agriculture, it is as a dipping solution to prevent superficial scald in the surface of apple. Diphenylamine also is a fungicide and was used in the pesticides with high concentration. It is an important derivative of BXT, and often used in hair color dye. It is toxic, possible mutagen and teratogen, and harmful in contact with skin. Because diphenylamine is a hapten, in this experiment, we use conjugate reagent to syn

APA, Harvard, Vancouver, ISO, and other styles

42

Yi-WenChang and 張憶文. "Discovery of antibodies by phage display human scFv antibody library." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/15750785477965469165.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Hu, Ting-Yuan. "Titanium-binding Peptide Isolated from Phage-displayed Random Peptide Library." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-3007200716354000.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Hu, Ting-Yuan, and 胡庭元. "Titanium-binding Peptide Isolated from Phage-displayed Random Peptide Library." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/93998814871702072948.

Full text

Abstract:

碩士<br>臺灣大學<br>臨床牙醫學研究所<br>95<br>Since the introduction of titanium root-form dental implant in 60’s, it has become a widely used treatment modality in rehabilitation of completely or partially edentulous patients. However, clinicians still face the failure of implant treatment or its complication, such as progressive marginal bone loss, recession of marginal mucosa, or absence of osseointegration, inspite of its reported high success and survival rates in the literatures. In late 90’s, the application of biomimetic modification has been introduced to overcome the problems because of the advanc

APA, Harvard, Vancouver, ISO, and other styles

45

huang, chi hung, and 黃濟鴻. "Generation of scFv against Thalidomide stereoisomer from phage display library." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/65105760400880058834.

Full text

Abstract:

碩士<br>國立中興大學<br>生物化學研究所<br>91<br>Thalidomide was first introduced in the 1950s as a sedative drug. Because it was deemed to be safe, it was prescribed for nausea and insomnia in pregnant women. However, it was found to cause the severe birth defects in children whose mothers had taken the drug in their first trimester of pregnancy. This was a terrible tragedy. Deepgoing research realized that one of thalidomide enantiomer possesses the desired therapeutic effect of quelling nausea, but its mirror compound produces fetal deformities. In this work, we synthesis thalidomide conjugated

APA, Harvard, Vancouver, ISO, and other styles

46

Hsia, Ko-Chiang, and 夏可強. "Isolation and characterization of lipase abzyme from phage displayed antibody library." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/mcyy49.

Full text

Abstract:

碩士<br>國立東華大學<br>生物技術研究所<br>94<br>Interactions of antigen and antibody resemble to some extents the recognition and specific binding between enzyme and substrate. For this reason, antibodies may have certain enzymatic activity and were named abzymes or catalytic antibodies. In the present work we aimed to get lipolytic abzymes through the selection from phage displayed antibody library. A transition state analog for selection of lipolytic abzymes was synthesized. The structure composed of 4-nitrophenyl activated phosphonate, the transition state analog, (TSA) of lipases/esterases, connected to

APA, Harvard, Vancouver, ISO, and other styles

47

"Applications of phage-displayed antibody library for antibody discovery and engineering." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074647.

Full text

Abstract:

Antibodies are one of the most useful molecules with affinity of binding and specificity for in vitro and in vivo diagnosis, or for immunotherapy of human diseases. In recent years, phage-displayed antibody library has been widely adopted to select tailor-made antibodies in a fast, high-throughput mode, as an alternative of traditional hybridoma technology. Although phage display has been introduced for about 20 years, the applications and development of this technology still have a rich space to be explored.<br>Attempts are made in the present study to extend three applications of the phage

APA, Harvard, Vancouver, ISO, and other styles

48

Tseng, Sy-Woei, and 曾斯偉. "Construction of phage-display peptide library for the screening of antibody epitope." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/04418277385769813527.

Full text

Abstract:

碩士<br>國立中興大學<br>分子生物學研究所<br>88<br>Abstract Phage display technology, consisting of the expression of target sequence in the surface of phage particles and the affinity selection, is a biological system that facilitates the cloning and rapid selection of peptides or proteins from large combinatorial libraries. Libraries are generated by cloning of a batch of DNA encoding millions of variants of certain ligands into the phage genome or phagemid as a fusion to the gene encoding one of the phage coat proteins. Upon expression, the fusion coat protein is incorporated into new phage part

APA, Harvard, Vancouver, ISO, and other styles

49

Ying-HsiuLiu and 劉盈秀. "Selection and characterization of EV71 antibody by phage display human scFv antibody library." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/42895278044035675388.

Full text

Abstract:

碩士<br>國立成功大學<br>醫學檢驗生物技術學系碩博士班<br>101<br>Enterovirus 71 (EV71) which causes hand-foot-mouth disease (HFMD) and herpangina belongs to the Picornaviridae family with ss(+) RNA virus. In 1998, EV71 outbreak in Taiwan and resulted in 78 fatal cases of 405 severe complications related neurological or cardiopulmonary symptoms. EV71 has been threatened the children under 3 years of age in Asia-Pacific area. Vaccination of EV71 seems the most efficient to eradicate the infectious disease. However, the development of vaccines is still in clinical trials. Antibodies also develop for early detection and

APA, Harvard, Vancouver, ISO, and other styles

50

Huang, Shih-Tsung, and 黃仕聰. "Development of Fully Human Anti-HDGF Antibody from Phage-Displayed Human Naïve ScFv Library." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/92wr6a.

Full text

Abstract:

博士<br>國立中山大學<br>海洋生物科技博士學位學程<br>107<br>Hepatocellular carcinoma (HCC), a deadly disease worldwide. For advanced HCC therapy, Sorafenib is the only conventional drug, however, low response rate, drug resistance, and strong side effects had been reported in Sorafenib therapy. Therefore, investigation of novel therapeutic strategy is a critical issue. HDGF is a cancerous factor in various cancer types including HCC. To develop anti-HDGF neutralizing antibody, phage display technology provides an effective in vitro selection strategy to identify fully human antibody. In the biopanning, thirteen HD

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!