Academic literature on the topic 'PH-responsive linker'
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Journal articles on the topic "PH-responsive linker"
Xiao, Zeyun, Ross Andrew Lennox Wylie, Emma Ruth Lucille Brisson, and Luke Andrew Connal. "pH-responsive fluorescent hydrogels using a new thioflavin T cross-linker." Journal of Polymer Science Part A: Polymer Chemistry 54, no. 5 (November 12, 2015): 591–95. http://dx.doi.org/10.1002/pola.27974.
Full textZhang, Junliang, Joji Tanaka, Pratik Gurnani, Paul Wilson, Matthias Hartlieb, and Sébastien Perrier. "Self-assembly and disassembly of stimuli responsive tadpole-like single chain nanoparticles using a switchable hydrophilic/hydrophobic boronic acid cross-linker." Polymer Chemistry 8, no. 28 (2017): 4079–87. http://dx.doi.org/10.1039/c7py00828g.
Full textLi, Bingqiang, Meng Shan, Xiang Di, Chu Gong, Lihua Zhang, Yanming Wang, and Guolin Wu. "A dual pH- and reduction-responsive anticancer drug delivery system based on PEG–SS–poly(amino acid) block copolymer." RSC Advances 7, no. 48 (2017): 30242–49. http://dx.doi.org/10.1039/c7ra04254j.
Full textDey, Soma, and K. Sreenivasan. "Conjugating curcumin to water soluble polymer stabilized gold nanoparticles via pH responsive succinate linker." Journal of Materials Chemistry B 3, no. 5 (2015): 824–33. http://dx.doi.org/10.1039/c4tb01731e.
Full textRao N, Vijayakameswara, ShivshankarR Mane, Abhinoy Kishore, Jayasri Das Sarma, and Raja Shunmugam. "Norbornene Derived Doxorubicin Copolymers as Drug Carriers with pH Responsive Hydrazone Linker." Biomacromolecules 13, no. 1 (December 6, 2011): 221–30. http://dx.doi.org/10.1021/bm201478k.
Full textThirupathi, Kokila, Thi Tuong Vy Phan, Madhappan Santhamoorthy, Vanaraj Ramkumar, and Seong-Cheol Kim. "pH and Thermoresponsive PNIPAm-co-Polyacrylamide Hydrogel for Dual Stimuli-Responsive Controlled Drug Delivery." Polymers 15, no. 1 (December 29, 2022): 167. http://dx.doi.org/10.3390/polym15010167.
Full textMehra, Saloni, Safiya Nisar, Sonal Chauhan, Gurmeet Singh, Virender Singh, and Sunita Rattan. "A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker." Polymer Chemistry 12, no. 16 (2021): 2404–20. http://dx.doi.org/10.1039/d0py01729a.
Full textAli, Shaikh A., Shuaib A. Mubarak, Ibrahim Y. Yaagoob, Zeeshan Arshad, and Mohammad A. J. Mazumder. "A sorbent containing pH-responsive chelating residues of aspartic and maleic acids for mitigation of toxic metal ions, cationic, and anionic dyes." RSC Advances 12, no. 10 (2022): 5938–52. http://dx.doi.org/10.1039/d1ra09234k.
Full textRuckenstein, Eli, and Hongmin Zhang. "A Novel Breakable Cross-Linker and pH-Responsive Star-Shaped and Gel Polymers." Macromolecules 32, no. 12 (June 1999): 3979–83. http://dx.doi.org/10.1021/ma990016d.
Full textAho, Aapo, Mika Sulkanen, Heidi Korhonen, and Pasi Virta. "Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker." Organic Letters 22, no. 17 (August 17, 2020): 6714–18. http://dx.doi.org/10.1021/acs.orglett.0c01815.
Full textDissertations / Theses on the topic "PH-responsive linker"
Mabire, A. B., Q. Brouard, Anaïs Pitto-Barry, R. J. Williams, H. Willcock, N. Kirby, E. Chapman, and R. K. O'Reilly. "CO2/pH-responsive particles with built-in fluorescence read-out." 2016. http://hdl.handle.net/10454/15381.
Full textA novel fluorescent monomer was synthesized to probe the state of CO2-responsive cross-linked polymeric particles. The fluorescent emission of this aminobromomaleimide-bearing monomer, being sensitive to protic environments, can provide information on the core hydrophilicity of the particles and therefore indicates the swollen state and size of the particles. The particles’ core, synthesized from DEAEMA (N,N-diethylaminoethyl methacrylate), is responsive to CO2 through protonation of the tertiary amines of DEAEMA. The response is reversible and the fluorescence emission can be recovered by simply bubbling nitrogen into the particle solution. Alternate purges of CO2 and N2 into the particles’ solution allow several ON/OFF fluorescence emission cycles and simultaneous particle swelling/shrinking cycles.
British Petroleum Company (BP), Engineering and Physical Sciences Research Council (EPSRC)
Chang, Yu-Jen, and 張佑仁. "pH/Thermo-Responsive Cross-Linked Copolymer/Drug Complex Micelles for Intracellular Drug Delivery." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/09089266846034161376.
Full text國立清華大學
生醫工程與環境科學系
100
In this study, the complex micelles were formed by electrostatic interaction between hydrophilic anticancer drug doxorubicin (DOX) and graft copolymers. The graft copolymers comprising acrylic acid and 2-methacryloylethyl acrylate (MEA) units as backbone and both poly(N-isopropylacrylamide) (PNIPAAm) and poly(ethylene glycol) (mPEG) as the grafts were synthesized. These micelles contain high stability by interchains cross-linking. After cross-linking, the particle size of polymeric complex micelles were ca. 53 nm and could be achieved high drug encapsulation efficiency (ca. 80 wt%) and loading content (ca. 40 wt%). In pH-triggered release, DOX were obviously released at pH 4.7 via the protonation of AAc residues on the copolymers, however, DOX would be contained in the micelles at pH 7.4. Besides, the released profile of these micelles was also thermal response. Because of the PNIPAAm on the copolymers, the released profile of micelles would be enhanced when the surrounding temperature was raised. In vitro cytotoxicity tests demonstrated the copolymers used in polymeric complex micelles were nontoxic while DOX-loaded polymeric complex micelles had well toxicity against Hela cells. Moreover, flow cytometry and confocal microscopy also showed the cellular uptake of polymeric complex micelles by Hela cells. These results indicate that these polymeric complex micelles could be provided with pH/thermo-triggered release profile and have highly potential in drug delivery system.
Chiang, Wen-Hsuan, and 姜文軒. "Synthesis of Thermo- and pH-Responsive Shell Cross-Linked Micelles and Their Micelle/Vesicle Morphology Transition." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/26190644601259786534.
Full text國立中興大學
化學工程學系所
97
Two graft copolymers comprising acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units as the backbone and either poly(N-isopropylacrylamide) (PNIPAAm) alone or both PNIPAAm and monomethoxypoly(ethylene glycol) (mPEG) as the grafts were synthesized. These copolymers in the aqueous phase (pH 5.0) underwent thermally induced self-assembly into micelles. For the copolymer containing PNIPAAm grafts only, extensive interactions between unionized AAc residues and PNIPAAm segments occurred, thereby rendering polymer backbones partially embedded within the hydrophobic cores of thermally induced micelles. This then led to bulk (core/shell) cross-linking of micelles upon radical polymerization of the MEA units within the micellar assemblies in the aqueous phase. By contrast, with mPEG being incorporated into the copolymer, association of the backbones with PNIPAAm is greatly retarded. As a result, three-layer onion-like polymeric micelles consisting of hydrophobic PNIPAAm cores surrounded by AAc-rich shells and hydrophilic mPEG coronas were achieved. Shell cross-linked micelles were then produced via polymerization of the MEA units confined to the AAc/MEA-rich shell regions. The presence or absence of mPEG in the PNIPAAm-containing graft copolymer plays a crucial role in determining the morphological structure of micelles and the structural responses of the subsequently cross-linked micelles to pH and temperature changes. More importantly, the morphology of SCL micelles in aqueous solutions can be altered readily by changing external pH and temperature. For SCL micelles at pH 7.0 and 20 oC, due to enhanced extent of AAc ionization in interfacial gel layers and the highly hydrated PNIPAAm segments and thus water influx, the swollen SCL micelles exhibit a more extend and vesicle-like structure. In addition, because of the relatively spatial segregation of the inner PNIPAAm segments, their subtle phase transition occurs only at high temperature and is incapable of changing obviously particle size and morphology. As solution pH is lowered to 3.0, the vesicular structure of SCL micelles can be maintained sufficiently by the hydrated inner PNIPAAm and outer mPEG segments surrounding the compact interfacial gel layers. Very interestingly, with increasing continually temperature, their significantly reduced size and Rg/Rh value suggest the morphological transition of SCL micelles from a vesicle-like sphere to a core-shell micelle through the development of a dense solid-like core from extensive hydrophobic PNIPAAm association and solidification. On the other hand, elevating the MEA content of graft copolymers can increase the cross-linking degree of SCL micelles to reduce their stimuli-responsive volume variation extent. In aqueous solutions of pH 7.4 and 37 oC, the SCL micelles display degradable property with hydrolysis of ester bonds between MEA residues and polymeric networks. In this study, the thermo- and pH-responsive structural transition of SCL micelles and their degradable property could accomplish potentially the requirements for drug delivery and controlled release applications.
Book chapters on the topic "PH-responsive linker"
Ruckenstein, Eli, and Hongmin Zhang. "A Novel Breakable Cross-linker and pH-Responsive Star-Shaped and Gel Polymers *." In Solution and Surface Polymerization, 81–91. CRC Press, 2019. http://dx.doi.org/10.1201/9780429027420-7.
Full textConference papers on the topic "PH-responsive linker"
Ning, Yuetong. "Schiff-linked prodrugs of pH-responsive nanoparticles with high drug loading and improved drug delivery." In 4TH INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FBSE 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0093876.
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