Journal articles on the topic 'PFKFB3 inhibitor'
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Sun, Chen-min, Da-bo Xiong, Yang Yan, Jiang Geng, Min Liu, and Xu-dong Yao. "Genetic Alteration in Phosphofructokinase Family Promotes Growth of Muscle-Invasive Bladder Cancer." International Journal of Biological Markers 31, no. 3 (July 2016): 286–93. http://dx.doi.org/10.5301/jbm.5000189.
Full textKotowski, Krzysztof, Jakub Rosik, Filip Machaj, Stanisław Supplitt, Daniel Wiczew, Karolina Jabłońska, Emilia Wiechec, Saeid Ghavami, and Piotr Dzięgiel. "Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets." Cancers 13, no. 4 (February 22, 2021): 909. http://dx.doi.org/10.3390/cancers13040909.
Full textRegueira, Mariana, Silvana Lucía Artagaveytia, María Noel Galardo, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, Silvina Beatriz Meroni, and María Fernanda Riera. "Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells." REPRODUCTION 150, no. 4 (October 2015): 311–21. http://dx.doi.org/10.1530/rep-15-0093.
Full textMinchenko, Oleksandr H., Iryna L. Opentanova, Tsutomu Ogura, Dmytro O. Minchenko, Sergiy V. Komisarenko, Jaime Caro, and Hiroyasu Esumi. "Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines." Acta Biochimica Polonica 52, no. 4 (July 11, 2005): 881–88. http://dx.doi.org/10.18388/abp.2005_3402.
Full textEmini Veseli, Besa, Pieter Van Wielendaele, Mirela Delibegovic, Wim Martinet, and Guido R. Y. De Meyer. "The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition." International Journal of Molecular Sciences 22, no. 11 (May 31, 2021): 5970. http://dx.doi.org/10.3390/ijms22115970.
Full textTruong, Thu Ha, Elizabeth A. Benner, Kyla M. Hagen, Nuri A. Temiz, Carlos Perez Kerkvliet, Ying Wang, Emilio Cortes-Sanchez, et al. "Steroid Receptor Co-Activators Regulate Metabolic Kinases to Drive Therapy Resistant ER+ Breast Cancer." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A1031—A1032. http://dx.doi.org/10.1210/jendso/bvab048.2111.
Full textZhou, Z., L. G. Plug, E. S. M. de Jonge-Muller, A. Abou Elmagd, A. E. van der Meulen-de Jong, M. C. Barnhoorn, and L. J. A. C. Hawinkels. "P028 Inhibition of stromal glycolysis by targeting PFKFB3 decreases experimental colitis." Journal of Crohn's and Colitis 16, Supplement_1 (January 1, 2022): i150. http://dx.doi.org/10.1093/ecco-jcc/jjab232.157.
Full textYu, Hongbin, Chuang Dai, Wei Zhu, Yude Jin, and Chunhui Wang. "PFKFB3 Increases IL-1β and TNF-α in Intestinal Epithelial Cells to Promote Tumorigenesis in Colitis-Associated Colorectal Cancer." Journal of Oncology 2022 (August 16, 2022): 1–8. http://dx.doi.org/10.1155/2022/6367437.
Full textGrewal, Jaspreet, Jamaal Ricthie, Numan Al Rayyan, Sucheta Telang, Kavitha Yaddanapudi, and Jason Chesney. "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is necessary for human melanoma MDSC differentiation and function." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 74.8. http://dx.doi.org/10.4049/jimmunol.196.supp.74.8.
Full textReddy, Mamatha M., Margret Fernandes, James D. Griffin, and Martin Sattler. "The JAK2V617F Oncogene, Associated with Myeloproliferative Neoplasms, Requires Expression of Inducible Phosphofructokinase/Fructose Bisphosphatase 3 for Cell Growth and Increased Metabolic Activity." Blood 116, no. 21 (November 19, 2010): 793. http://dx.doi.org/10.1182/blood.v116.21.793.793.
Full textCao, Yapeng, Xiaoyu Zhang, Lina Wang, Qiuhua Yang, Qian Ma, Jiean Xu, Jingjing Wang, et al. "PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension." Proceedings of the National Academy of Sciences 116, no. 27 (June 18, 2019): 13394–403. http://dx.doi.org/10.1073/pnas.1821401116.
Full textJones, Brandon C., Surojeet Sengupta, Catherine M. Sevigny, Lu Jin, Paula R. Pohlmann, Ayesha Shajahan-Haq, and Robert Clarke. "Abstract P4-02-10: Pfkfb3 inhibition significantly decreases endocrine-resistant breast cancer growth and induces necroptotic cell death." Cancer Research 82, no. 4_Supplement (February 15, 2022): P4–02–10—P4–02–10. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-02-10.
Full textZhang, Yongsheng, Yukun Liu, Zhenxing Xie, Qinxin Liu, Yangfan Zhuang, Weiming Xie, Xiang Wang, et al. "Inhibition of PFKFB Preserves Intestinal Barrier Function in Sepsis by Inhibiting NLRP3/GSDMD." Oxidative Medicine and Cellular Longevity 2022 (December 23, 2022): 1–13. http://dx.doi.org/10.1155/2022/8704016.
Full textZhu, Yu, Jianyong Li, Chun Qiao, Yi Shan, Sixuan Qian, Yaoyu Chen, Ming Hong, et al. "PFKFB3 Is a Crucial Target in the Treatment of Tyrosine Kinase Inhibitor Resistant Chronic Myelogenous Leukemia." Blood 128, no. 22 (December 2, 2016): 3936. http://dx.doi.org/10.1182/blood.v128.22.3936.3936.
Full textDe Oliveira, Tiago, Tina Goldhardt, Marcus Edelmann, Torben Rogge, Karsten Rauch, Nikola Dobrinov Kyuchukov, Kerstin Menck, et al. "Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo." Cancers 13, no. 5 (February 28, 2021): 1011. http://dx.doi.org/10.3390/cancers13051011.
Full textWarrier, Govind, Lilibeth Lanceta, Yoannis Imbert-Fernandez, and Jason Alan Chesney. "Inhibition of glucose metabolism through treatment of BRAF mutated metastatic melanoma with vemurafenib." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e21005-e21005. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21005.
Full textZhang, Yang, Weifang Liu, Yanqi Zhong, Qi Li, Mengying Wu, Liu Yang, Xiaoxia Liu, and Li Zou. "Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia." Oxidative Medicine and Cellular Longevity 2021 (November 11, 2021): 1–22. http://dx.doi.org/10.1155/2021/1806344.
Full textZhu, Yu, Luo Lu, Chun Qiao, Yi Shan, Huapeng Li, Sixuan Qian, Ming Hong, et al. "Targeting PFKFB3 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitor." Oncogene 37, no. 21 (March 7, 2018): 2837–49. http://dx.doi.org/10.1038/s41388-018-0157-8.
Full textParker, Gretchen E., Bartholomew A. Pederson, Mariko Obayashi, Jill M. Schroeder, Robert A. Harris, and Peter J. Roach. "Gene expression profiling of mice with genetically modified muscle glycogen content." Biochemical Journal 395, no. 1 (March 15, 2006): 137–45. http://dx.doi.org/10.1042/bj20051456.
Full textBenner, Elizabeth, Camila Dos Santos, Kyla Hagen, Carol Lange, Julie Ostrander, Nuri Temiz, Marygrace Trousdell, and Thu Truong. "OR16-2 Steroid Receptor Co-Activator Complexes Regulate Metabolic PFKFB Enzymes to Drive Therapy Resistant ER+ Breast Cancer." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A879—A880. http://dx.doi.org/10.1210/jendso/bvac150.1821.
Full textOkabe, Seiichi, Yuko Tanaka, Mitsuru Moriyama, and Akihiko Gotoh. "Targeting Glycolysis in Multiple Myeloma: Novel Strategies in the Treatment of Proteasome Inhibitor Resistant in Hypoxic Conditions." Blood 134, Supplement_1 (November 13, 2019): 4344. http://dx.doi.org/10.1182/blood-2019-129818.
Full textGómez, Marta, Anna Manzano, Agnes Figueras, Francesc Viñals, Francesc Ventura, Jose Luis Rosa, Ramon Bartrons, and Àurea Navarro-Sabaté. "Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway." American Journal of Physiology-Endocrinology and Metabolism 303, no. 6 (September 15, 2012): E695—E707. http://dx.doi.org/10.1152/ajpendo.00381.2011.
Full textSimula, Luca, Marco Alifano, and Philippe Icard. "How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives." Cancers 14, no. 10 (May 18, 2022): 2478. http://dx.doi.org/10.3390/cancers14102478.
Full textZlacká, Jana, Miroslav Murár, Gabriela Addová, Roman Moravčík, Andrej Boháč, and Michal Zeman. "Synthesis of Glycolysis Inhibitor PFK15 and Its Synergistic Action with an Approved Multikinase Antiangiogenic Drug on Human Endothelial Cell Migration and Proliferation." International Journal of Molecular Sciences 23, no. 22 (November 18, 2022): 14295. http://dx.doi.org/10.3390/ijms232214295.
Full textRedman, Rebecca Ann, Paula Raffin Pohlmann, Michael R. Kurman, Gilles Tapolsky, and Jason Chesney. "A phase I, dose-escalation, multicenter study of ACT-PFK-158, 2HCl in patients with advanced solid malignancies explores a first-in-human inhibitor of glycolysis." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): TPS494. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.tps494.
Full textTelang, Sucheta, Julie O’Neal, Gilles Tapolsky, Brian Clem, Alan Kerr, Yoannis Imbert-Ferndandez, and Jason Chesney. "Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib." Cancer & Metabolism 2, Suppl 1 (2014): P14. http://dx.doi.org/10.1186/2049-3002-2-s1-p14.
Full textGuan, Shuyuan, Lingbin Sun, Xihua Wang, Xirui Huang, and Tao Luo. "Isoschaftoside Inhibits Lipopolysaccharide-Induced Inflammation in Microglia through Regulation of HIF-1α-Mediated Metabolic Reprogramming." Evidence-Based Complementary and Alternative Medicine 2022 (November 23, 2022): 1–8. http://dx.doi.org/10.1155/2022/5227335.
Full textMondal, Susmita, Debarshi Roy, Sayantani Sarkar Bhattacharya, Ling Jin, Deokbeom Jung, Song Zhang, Eleftheria Kalogera, et al. "Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers." International Journal of Cancer 144, no. 1 (October 30, 2018): 178–89. http://dx.doi.org/10.1002/ijc.31868.
Full textErlandsson, M., K. M. Andersson, N. Oparina, S. Töyrä Silfverswärd, and M. I. Bokarewa. "OP0315 EFFECTOR CD4 T CELLS REQUIRE SURVIVIN FOR REGULATION OF GLUCOSE METABOLISM AND IFNg PRODUCTION." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 192.2–193. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2295.
Full textZhu, Wei, Liang Ye, Jianzhao Zhang, Pengfei Yu, Hongbo Wang, Zuguang Ye, and Jingwei Tian. "PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer." PLOS ONE 11, no. 9 (September 26, 2016): e0163768. http://dx.doi.org/10.1371/journal.pone.0163768.
Full textZhang, Y., A. Nguyen, A. Rudin, and C. Maglio. "POS0425 METABOLIC ALTERATIONS IN ACTIVATED FIBROBLAST-LIKE SYNOVIOCYTES FROM NON-INFLAMED SUBJECTS - MIMICKING EARLY STAGE OF RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 467.1–467. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2806.
Full textChang, Simone, Evan Meiman, and Sucheta Telang. "DDRE-34. TARGETING RESISTANCE IN MEDULLOBLASTOMA." Neuro-Oncology Advances 3, Supplement_1 (March 1, 2021): i14. http://dx.doi.org/10.1093/noajnl/vdab024.056.
Full textCao, Xiankun, Xin Wang, Kewei Rong, Kexin Liu, Xiao Yang, Tangjun Zhou, Pu Zhang, et al. "Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells." Oxidative Medicine and Cellular Longevity 2022 (September 21, 2022): 1–17. http://dx.doi.org/10.1155/2022/7548145.
Full textYan, Siyuan, Nan Zhou, Deru Zhang, Kaile Zhang, Wenao Zheng, Yonghua Bao, and Wancai Yang. "PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells." International Journal of Molecular Sciences 20, no. 21 (October 30, 2019): 5415. http://dx.doi.org/10.3390/ijms20215415.
Full textÄhrlund-Richter, Lars, Katarina Färnegårdh, Elisee Wiita, Mattias Jönsson, Carina Norström, Jessica Martinsson, Kenth Hallberg, Rune Ringom, and Hakan Mellstedt. "Metabolic intervention targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) using a structure-based design." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e13518-e13518. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13518.
Full textLyu, Zhong-Shi, Wei-Li Yao, Qi Wen, Hong-Yan Zhao, Fei-Fei Tang, Yu Wang, Lan-Ping Xu, et al. "Glycolysis Restoration Attenuates Damaged Bone Marrow Endothelial Cells." Blood 134, Supplement_1 (November 13, 2019): 2491. http://dx.doi.org/10.1182/blood-2019-122794.
Full textWen, Qi, Song Yang, Zhong-Shi Lyu, Wei-Li Yao, Yu-Hong Chen, Ting-Ting Han, Yu Wang, et al. "Regulation of the Elevated T Cell Glycolysis May Alleviate Acute Graft-Versus-Host Disease Post-Allotransplant." Blood 134, Supplement_1 (November 13, 2019): 600. http://dx.doi.org/10.1182/blood-2019-122795.
Full textIkeda, Sho, Fumito Abe, Matsuda Yuka, Akihiro Kitadate, Takahiro Kobayashi, Naoto Takahashi, and Hiroyuki Tagawa. "Hexokinase-2 Regulates Hypoxia-Inducible Autophagy, Leading to Enhance Anti-Apoptotic Capability of Refractory Multiple Myeloma." Blood 134, Supplement_1 (November 13, 2019): 1787. http://dx.doi.org/10.1182/blood-2019-123360.
Full textPetrasca, Andreea, James J. Phelan, Sharon Ansboro, Douglas J. Veale, Ursula Fearon, and Jean M. Fletcher. "Targeting bioenergetics prevents CD4 T cell–mediated activation of synovial fibroblasts in rheumatoid arthritis." Rheumatology 59, no. 10 (February 11, 2020): 2816–28. http://dx.doi.org/10.1093/rheumatology/kez682.
Full textLu, Yan, Lei Zhang, Ran Zhu, Huijuan Zhou, Huaying Fan, and Qiang Wang. "PFKFB3, a key glucose metabolic enzyme regulated by pathogen recognition receptor TLR4 in liver cells." Therapeutic Advances in Endocrinology and Metabolism 11 (January 2020): 204201882092347. http://dx.doi.org/10.1177/2042018820923474.
Full textKhodova, Kristina, Mikhail Pyatnitskiy, Tatiana Eremeeva, and Peter Fedichev. "Application of bioinformatics approach to identify indications for PFKFB3-mediated glycolysis inhibition as potential anticancer treatment." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e23158-e23158. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23158.
Full textGao, Liansheng, Chun Wang, Bing Qin, Tao Li, Weilin Xu, Cameron Lenahan, Guangyu Ying, et al. "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and “cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats." Cell Transplantation 29 (January 1, 2020): 096368972095022. http://dx.doi.org/10.1177/0963689720950226.
Full textLypova, Nadiia, Susan M. Dougherty, Lilibeth Lanceta, Jason Chesney, and Yoannis Imbert-Fernandez. "PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs." Cells 10, no. 7 (July 3, 2021): 1679. http://dx.doi.org/10.3390/cells10071679.
Full textSt-Gallay, Stephen A., Neil Bennett, Susan E. Critchlow, Nicola Curtis, Gareth Davies, Judit Debreczeni, Nicola Evans, et al. "A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors." SLAS DISCOVERY: Advancing the Science of Drug Discovery 23, no. 1 (September 25, 2017): 11–22. http://dx.doi.org/10.1177/2472555217732289.
Full textNovellasdemunt, Laura, Laurent Bultot, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Didier Vertommen, Mark H. Rider, Àurea Navarro-Sabate, and Ramon Bartrons. "PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli." Biochemical Journal 452, no. 3 (May 31, 2013): 531–43. http://dx.doi.org/10.1042/bj20121886.
Full textLane, Daniel Scot, Priyanka Talukdar, Beth Fallert Junecko, and Joshua T. Mattila. "Inhibiting glycolysis by targeting the enzyme PFKFB3 restricts macrophage anti-mycobacterial activity and neutrophil phagocytosis of Mycobacterium tuberculosis." Journal of Immunology 208, no. 1_Supplement (May 1, 2022): 110.03. http://dx.doi.org/10.4049/jimmunol.208.supp.110.03.
Full textGrewal, Jaspreet Singh, Numan Al-Rayyan, Jamaal Ritchie, Paxton Schowe, Cam Falkner, Sucheta Telang, Kavitha Yaddanapudi, and Jason Alan Chesney. "Targeting the glucose metabolism of monocytic myeloid-derived suppressor cells to stimulate cancer immunity." Journal of Clinical Oncology 35, no. 7_suppl (March 1, 2017): 126. http://dx.doi.org/10.1200/jco.2017.35.7_suppl.126.
Full textErlandsson, M., E. Malmhäll-Bah, K. M. Andersson, S. Töyrä Silfverswärd, R. Pullerits, and M. I. Bokarewa. "POS0702 ANTI-RHEUMATIC TREATMENT ALTERS PFKFB3 EXPRESSION, KEY OF GLYCOLYSIS, IN CD14+ MONOCYTES OF RA PATIENTS, WHICH CONTRIBUTES TO DISSIMILARITIES OF THE IFNg-SIGNATURE." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 631.1–631. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4562.
Full textBobarykina, Anastasiya Y., Dmytro O. Minchenko, Iryna L. Opentanova, Michel Moenner, Jaime Caro, Hiroyasu Esumi, and Oleksandr H. Minchenko. "Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers." Acta Biochimica Polonica 53, no. 4 (December 4, 2006): 789–99. http://dx.doi.org/10.18388/abp.2006_3308.
Full textBoyd, Scott, Joanna L. Brookfield, Susan E. Critchlow, Iain A. Cumming, Nicola J. Curtis, Judit Debreczeni, Sébastien L. Degorce, et al. "Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3." Journal of Medicinal Chemistry 58, no. 8 (April 13, 2015): 3611–25. http://dx.doi.org/10.1021/acs.jmedchem.5b00352.
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