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Journal articles on the topic 'Personalised Search Agents'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Cosway, B., V. Paleri, and J. Wilson. "Biomarkers predicting chemotherapy response in head and neck squamous cell carcinoma: a review." Journal of Laryngology & Otology 129, no. 11 (2015): 1046–52. http://dx.doi.org/10.1017/s0022215115002479.

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AbstractBackground:Biomarkers are increasingly being used in many cancers to select patients for oncological treatment paradigms based on their inherent genetic properties. However, in head and neck cancers, there are no personalised therapies available outside the context of a clinical trial. A number of studies suggest there are intrinsic tumour properties of head and neck cancers that affect their response to chemotherapeutic agents. This paper aimed to review their evidence base.Method:A narrative review was conducted following a search of the PubMed database.Results and conclusion:The rev

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Gisbert, Javier P., and María Chaparro. "Predictors of Primary Response to Biologic Treatment [Anti-TNF, Vedolizumab, and Ustekinumab] in Patients With Inflammatory Bowel Disease: From Basic Science to Clinical Practice." Journal of Crohn's and Colitis 14, no. 5 (2019): 694–709. http://dx.doi.org/10.1093/ecco-jcc/jjz195.

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Abstract Background Inflammatory bowel diseases [IBD]―ulcerative colitis and Crohn’s disease―are commonly treated with biologic drugs. However, only approximately two-thirds of patients have an initial response to these therapies. Personalised medicine has the potential to optimise efficacy, decrease the risk of adverse drug events, and reduce costs by establishing the most suitable therapy for a selected patient. Aim The present study reviews the potential predictors of short-term primary response to biologic treatment, including not only anti-tumour necrosis factor [TNF] agents [such as infl

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Wang, Rui, Wentao Li, Esmée M. Bordewijk, et al. "First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis." Human Reproduction Update 25, no. 6 (2019): 717–32. http://dx.doi.org/10.1093/humupd/dmz029.

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Abstract BACKGROUND Polycystic ovary syndrome (PCOS) is the most frequent cause of anovulatory infertility. In women with PCOS, effective ovulation induction serves as an important first-line treatment for anovulatory infertility. Individual participant data (IPD) meta-analysis is considered as the gold standard for evidence synthesis which provides accurate assessments of outcomes from primary randomised controlled trials (RCTs) and allows additional analyses for time-to-event outcomes. It also facilitates treatment–covariate interaction analyses and therefore offers an opportunity for person

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GODOY, DANIELA, and ANALÍA AMANDI. "COLLABORATIVE WEB SEARCH BASED ON USER INTEREST SIMILARITY." International Journal of Cooperative Information Systems 17, no. 04 (2008): 495–521. http://dx.doi.org/10.1142/s0218843008001907.

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The motivation behind personal information agents resides in the enormous amount of information available on the Web, which has created a pressing need for effective personalized techniques. In order to assists Web search these agents rely on user profiles modeling information preferences, interests and habits that help to contextualize user queries. In communities of people with similar interests, collaboration among agents fosters knowledge sharing and, consequently, potentially improves the results of individual agents by taking advantage of the knowledge acquired by other agents. In this p

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Rattrout, Amjad, Rasha Assaf, and Ali Al-Dahoud. "Personalizing the dynamic information resources in a self organized web system using CAS and MAS." Computer Science and Information Systems 7, no. 4 (2010): 883–905. http://dx.doi.org/10.2298/csis090608023r.

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The Web is a constantly growing dynamic environment where the components are changed in non-linear ways. These components represent the targets to researches in order to better understand the behavior of the Web, where the owners and the users in this environment exist as out factors. Web page Usage information is the term which describes ways and methods of using the Web. Various factors affect the use of the diversity of the resources in the Web, The non-linear way of its growth, and the evolution in the methods for how we build the Web pages which eventually leads to reflecting the users? i

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Kocaballi, Ahmet Baki, Shlomo Berkovsky, Juan C. Quiroz, et al. "The Personalization of Conversational Agents in Health Care: Systematic Review." Journal of Medical Internet Research 21, no. 11 (2019): e15360. http://dx.doi.org/10.2196/15360.

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Background The personalization of conversational agents with natural language user interfaces is seeing increasing use in health care applications, shaping the content, structure, or purpose of the dialogue between humans and conversational agents. Objective The goal of this systematic review was to understand the ways in which personalization has been used with conversational agents in health care and characterize the methods of its implementation. Methods We searched on PubMed, Embase, CINAHL, PsycInfo, and ACM Digital Library using a predefined search strategy. The studies were included if

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Savinova, A. R., and I. G. Gataullin. "Personalized approach to the ovarian cancer treatment." Kazan medical journal 97, no. 3 (2016): 388–93. http://dx.doi.org/10.17750/kmj2016-388.

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The aim of the review is to summarize the modern views on etiopathogenesis and treatment of ovarian cancer, as well as to search for ways for a more personalized approach to the management of patients with this oncological disease. Despite the limited number of patients participating in clinical trials of ovarian cancer, there are obvious results of gradual evolution in its diagnosis and treatment. Studies of etiopathogenesis led to a better understanding of the ovarian cancer genesis mechanisms, whereas evolution in treatment was marked by combination of secondary cytoreductive surgery with t

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Snoch, Wojciech, Dawid Wnuk, Tomasz Witko, et al. "In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers." International Journal of Molecular Sciences 22, no. 13 (2021): 7238. http://dx.doi.org/10.3390/ijms22137238.

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Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE’s hydrophobic chains can influence their cytotoxicity against human

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Abdulrahman, Amal, and Deborah Richards. "In Search of Embodied Conversational and Explainable Agents for Health Behaviour Change and Adherence." Multimodal Technologies and Interaction 5, no. 9 (2021): 56. http://dx.doi.org/10.3390/mti5090056.

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Conversational agents offer promise to provide an alternative to costly and scarce access to human health providers. Particularly in the context of adherence to treatment advice and health behavior change, they can provide an ongoing coaching role to motivate and keep the health consumer on track. Due to the recognized importance of face-to-face communication and establishment of a therapist-patient working alliance as the biggest single predictor of adherence, our review focuses on embodied conversational agents (ECAs) and their use in health and well-being interventions. The article also int

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Nebbioso, Marcella, Alessandro Lambiase, Alberto Cerini, Paolo Giuseppe Limoli, Maurizio La Cava, and Antonio Greco. "Therapeutic Approaches with Intravitreal Injections in Geographic Atrophy Secondary to Age-Related Macular Degeneration: Current Drugs and Potential Molecules." International Journal of Molecular Sciences 20, no. 7 (2019): 1693. http://dx.doi.org/10.3390/ijms20071693.

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The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called immunomodulatory or anti-inflammatory agents. A systematic literature search was performed to identify randomized controlled trials published prior to January 2019. Patients affected by dry AMD treated with intravitreal therapeutic agents were included. Changes in the correct visual acuity and reduction in geographic atrophy progression were evaluat

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Gao, Ke Lian, Yan Xia Cao, and Hai Yan Zhao. "Research on Network Fitness Service System Based on Multi-Agent Technology." Advanced Materials Research 926-930 (May 2014): 2394–97. http://dx.doi.org/10.4028/www.scientific.net/amr.926-930.2394.

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This paper uses Agent technology into the application of network fitness service system, and establishes the network fitness service system model based on multi-agent. Each agent in the model takes charge of different work, which is like client interest modeling, information search, information push and client interaction. Each agent is independent with others. Agents cooperate together, and complete personalized service to change the traditional passive service to active service. This can improve use ratio of network fitness service system and users satisfaction effectively.

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Pallio, Giovanni, Federica Mannino, Natasha Irrera, Ali H. Eid, Francesco Squadrito, and Alessandra Bitto. "Polymorphisms Involved in Response to Biological Agents Used in Rheumatoid Arthritis." Biomolecules 10, no. 9 (2020): 1203. http://dx.doi.org/10.3390/biom10091203.

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Rheumatoid arthritis (RA) is a systemic disease that leads to joint destruction. During the last decade, the therapy of RA has been principally based on biological drugs. Although the efficacy of biological therapy has been established, patients demonstrated a high heterogeneity in clinical response to treatment. Several genetic polymorphisms play a part in the different response to biological drugs. This review summarizes the pharmacogenetics of biological agents approved for clinical RA treatment. We reviewed PubMed papers published over the past 20 years (2000–2020), inserting as the search

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Schwaederle, Maria, Melissa Zhao, J. Jack Lee, et al. "Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials." Journal of Clinical Oncology 33, no. 32 (2015): 3817–25. http://dx.doi.org/10.1200/jco.2015.61.5997.

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Purpose The impact of a personalized cancer treatment strategy (ie, matching patients with drugs based on specific biomarkers) is still a matter of debate. Methods We reviewed phase II single-agent studies (570 studies; 32,149 patients) published between January 1, 2010, and December 31, 2012 (PubMed search). Response rate (RR), progression-free survival (PFS), and overall survival (OS) were compared for arms that used a personalized strategy versus those that did not. Results Multivariable analysis (both weighted multiple linear regression and random effects meta-regression) demonstrated that

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Ji, Zhi Gang. "The Study on Personalized Guidance in Intelligent Library Based on Multi-Agent." Advanced Materials Research 143-144 (October 2010): 18–22. http://dx.doi.org/10.4028/www.scientific.net/amr.143-144.18.

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The system integrated RFID technique, wireless and mobile phone which apply in the intelligent guidance and book management of large scale of library, and to collate the real time information by different functional mobile agents to provide customized information and service, according to the favorite of each reader. Meanwhile, to display forgoing information by multimedia video of book introduction for readers to replace traditional looking for some particular book provide the customized knowledge search style and effective book introduction. In addition, our article set forth System Environm

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Smith, Sonali M. "What Is the Best Strategy for Incorporating New Agents into the Current Treatment of Follicular Lymphoma?" American Society of Clinical Oncology Educational Book, no. 32 (June 2012): 481–87. http://dx.doi.org/10.14694/edbook_am.2012.32.38.

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Overview: Although there is increasing knowledge about the pathobiology of follicular lymphoma (FL), the incorporation of new agents is challenged by the long clinical course and inherent heterogeneity of the disease. Furthermore, a longstanding concept in FL is that although most patients have an indolent initial phase of disease, this is typically followed by sequentially shorter remission durations and justifies the continued intense search for new rationally designed agents. Ideally, there would be personalized prognostic tools, preemptive target identification, and means to predict respon

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Gaudreau, Pierre-Olivier, John Stagg, Denis Soulières, and Fred Saad. "The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics, and Immunology Advancements." Biomarkers in Cancer 8s2 (January 2016): BIC.S31802. http://dx.doi.org/10.4137/bic.s31802.

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Prostate cancer (PC) is the second most common form of cancer in men worldwide. Biomarkers have emerged as essential tools for treatment and assessment since the variability of disease behavior, the cost and diversity of treatments, and the related impairment of quality of life have given rise to a need for a personalized approach. High-throughput technology platforms in proteomics and genomics have accelerated the development of biomarkers. Furthermore, recent successes of several new agents in PC, including immunotherapy, have stimulated the search for predictors of response and resistance a

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Kantemirova, B. I., E. A. Orlova, O. S. Polunina, E. N. Chernysheva, M. A. Abdullaev, and D. A. Sychev. "PHARMACOGENETIC BASES OF INDIVIDUAL SENSITIVITY AND PERSONALIZED ADMINISTRATION OF ANTIPLATELET THERAPY IN DIFFERENT ETHNIC GROUPS." Pharmacy & Pharmacology 8, no. 6 (2021): 392–404. http://dx.doi.org/10.19163/2307-9266-2020-8-6-392-404.

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Cardiovascular diseases (CVDs) are the leading cause of disability and mortality worldwide. Increased thrombosis is the trigger point for the development of various CVDs and their complications, and therefore, therapy with P2Y12-receptor inhibitors is always pathogenetically justified and vital. However, according to the various data, 10-25% of patients treated with clopidogrel have “resistance” to antiplatelet therapy. The causes for the formation of resistance are still not clear. There is no generally accepted, standard methodology for determining resistance to antiplatelet agents. In addit

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OHTANI, TAKESHI, SIMON CASE, NADER AZARMI, and MARCUS THINT. "AN INTELLIGENT SYSTEM FOR MANAGING AND UTILIZING INFORMATION RESOURCES OVER THE INTERNET." International Journal on Artificial Intelligence Tools 11, no. 01 (2002): 117–38. http://dx.doi.org/10.1142/s0218213002000800.

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The Internet is a vast, semi-structured information repository that is expanding ever-faster with two alarming results. First, finding information is becoming increasingly difficult, and second, the management of such information resources is also becoming more complex. We have developed an Intelligent Distributed Information Management System (IDIoMS) to solve these problems. IDIoMS provides a comprehensive set of tools for personalized information delivery, and a platform that enables straightforward management of distributed information resources using agent technologies. These agents enabl

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Aardoom, Martine A., Gigi Veereman, and Lissy de Ridder. "A Review on the Use of Anti-TNF in Children and Adolescents with Inflammatory Bowel Disease." International Journal of Molecular Sciences 20, no. 10 (2019): 2529. http://dx.doi.org/10.3390/ijms20102529.

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Inflammatory bowel disease (IBD) presents with disabling symptoms and may lead to insufficient growth and late pubertal development in cases of disease onset during childhood or adolescence. During the last decade, the role of anti-tumor necrosis factor (TNF) in the treatment of paediatric-onset IBD has gained more ground. The number of biologicals presently available for children and adolescents with IBD has increased, biosimilars have become available, and practices in adult gastroenterology with regards to anti-TNF have changed. The aim of this study is to review the current evidence on the

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Morris, Stephanie A., Sharon Gaheen, Michal Lijowski, Mervi Heiskanen, and Juli Klemm. "Experiences in supporting the structured collection of cancer nanotechnology data using caNanoLab." Beilstein Journal of Nanotechnology 6 (July 21, 2015): 1580–93. http://dx.doi.org/10.3762/bjnano.6.161.

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The cancer Nanotechnology Laboratory (caNanoLab) data portal is an online nanomaterial database that allows users to submit and retrieve information on well-characterized nanomaterials, including composition, in vitro and in vivo experimental characterizations, experimental protocols, and related publications. Initiated in 2006, caNanoLab serves as an established resource with an infrastructure supporting the structured collection of nanotechnology data to address the needs of the cancer biomedical and nanotechnology communities. The portal contains over 1,000 curated nanomaterial data records

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Janardhan, Sridhara, Varvara Dubovskaja, Alexey Lagunin, Batchu Venkateswara Rao, Garikapati Narahari Sastry, and Vladimir Poroikov. "Recent Advances in the Development of Pharmaceutical Agents for Metabolic Disorders: A Computational Perspective." Current Medicinal Chemistry 25, no. 39 (2019): 5432–63. http://dx.doi.org/10.2174/0929867324666171002120647.

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Background: Metabolic disorders comprise a set of different disorders varying from epidemic diseases such as diabetes mellitus to inborn metabolic orphan diseases such as phenylketonuria. Despite considerable evidence showing the importance of the computational methods in discovery and development of new pharmaceuticals, there are no systematic reviews outlining how they are utilized in the field of metabolic disorders. This review aims to discuss the necessity of the development of web-based tools and databases by integration of available information for solving Big Data problems in network p

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Benfaremo, Devis, Valentino Paci, Michele Maria Luchetti, and Armando Gabrielli. "Novel Therapeutic Approaches and Treatment Targets for Psoriatic Arthritis." Current Pharmaceutical Biotechnology 22, no. 1 (2020): 85–98. http://dx.doi.org/10.2174/1389201021666200928095521.

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Background: Psoriatic Arthritis (PsA) is the most common extracutaneous manifestation of psoriasis. This chronic inflammatory arthritis is burdened with significant morbidity, leading to irreversible joint damage and disability. In recent years, a deeper understating of its pathogenesis has led to the development of several new drugs targeting different pathways. Objectives: This review aims to highlight the clinical efficacy and safety of the novel agents that have become recently available for the treatment of PsA, as well as new promising therapeutic targets that are being evaluated in clin

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Rosenkranz, A. A., and T. A. Slastnikova. "Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery." Biochemistry (Moscow) 85, no. 9 (2020): 967–93. http://dx.doi.org/10.1134/s0006297920090011.

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Abstract Epidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular response to a number of growth factors. Its overexpression and increased activation due to mutations is one of the most common traits of many types of cancer. Development and clinical use of the agents, which block EGFR activation, became a prime example of the personalized targeted medicine. However, despite the obvious success in this area, cancer cure remains unattainable in most cases. Because of that, as well as the result of the search for possible ways to overcome the difficulties of treat

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Ribaldone, Davide Giuseppe, Selvaggia Brigo, Michela Mangia, Giorgio Maria Saracco, Marco Astegiano, and Rinaldo Pellicano. "Oral Manifestations of Inflammatory Bowel Disease and the Role of Non-Invasive Surrogate Markers of Disease Activity." Medicines 7, no. 6 (2020): 33. http://dx.doi.org/10.3390/medicines7060033.

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Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), can be associated with several extra-intestinal manifestations requiring a multidisciplinary management both in terms of work-up and therapy. Oral lesions are common in patients with IBD, with a prevalence ranging from 5% to 50%. These can represent an oral location of IBD as well as a side-effect of drugs used to treat the intestinal disease. Oral manifestations, occurring in patients with IBD, can be divided in nonmalignant, specific, and non-specific ones, and malignant lesions. While there is

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Jones, Christopher R., Barnaby F. Flower, Ella Barber, Bryony Simmons, and Graham S. Cooke. "Treatment optimisation for hepatitis C in the era of combination direct-acting antiviral therapy: a systematic review and meta-analysis." Wellcome Open Research 4 (September 6, 2019): 132. http://dx.doi.org/10.12688/wellcomeopenres.15411.1.

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Background: Prior to direct-acting antiviral (DAA) therapy, personalised medicine played an important role in the treatment of hepatitis C virus (HCV). Whilst simplified treatment strategies are central to treatment scale-up, some patients will benefit from treatment optimisation. This systematic review and meta-analysis explores treatment optimisation strategies in the DAA era. Methods: We systematically searched Medline, Embase, and Web of Science for studies that adopted a stratified or personalised strategy using a licensed combination DAA regimen, alone or with additional agents. We perfo

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Wu, Catherine J. "Checkpoint Blockade with Neoantigen Cancer Vaccines for Personalized Immunotherapy." Blood 126, no. 23 (2015): SCI—9—SCI—9. http://dx.doi.org/10.1182/blood.v126.23.sci-9.sci-9.

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Methods for harnessing the exquisite specificity of the immune system to eliminate tumors have been under development since the start of the 20th century, with numerous studies in animal models and trials in humans. Despite accumulating evidence, there has been widespread skepticism in the cancer community about whether tumors could be controlled by spontaneous immunity, and whether effective immunotherapy would be feasible to develop. However, the field has now passed an inflection point as new results have quelled these doubts, including: (i) several large clinical studies that have identifi

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Morales, Enrique, Maria Galindo, Hernando Trujillo, and Manuel Praga. "Update on Lupus Nephritis: Looking for a New Vision." Nephron 145, no. 1 (2020): 1–13. http://dx.doi.org/10.1159/000511268.

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Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), affecting approximately 40% of patients with lupus. It represents a major risk factor for morbidity and mortality, and 10% of patients with LN will develop end-stage kidney disease (ESKD). Therefore, there are a number of areas for improvement in the field of LN such as the search for new clinical biomarkers with a more accurate correlation with lupus activity and the redefinition of the histological classification into different subgroups in order to guide a personalized treatment. Although th

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Trainer, Alison H., Bettina Meiser, Kaaren Watts, Gillian Mitchell, Kathy Tucker, and Michael Friedlander. "Moving Toward Personalized Medicine: Treatment-Focused Genetic Testing of Women Newly Diagnosed With Ovarian Cancer." International Journal of Gynecologic Cancer 20, no. 5 (2010): 704–16. http://dx.doi.org/10.1111/igc.0b013e3181dbd1a5.

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Objectives:The presence of a germline BRCA mutation defines a genotype-specific group of women whose invasive ovarian cancer is associated with an increasingly well-defined prognostic and chemosensitivity biological profile. To determine the criteria that may be used to select patients for BRCA treatment-focused genetic testing, we performed a systemic literature search of studies that assessed BRCA1 and BRCA2 mutation frequency in women with ovarian cancer unselected for family history. The results are discussed with regard to the added clinical value gained by identifying a germline BRCA mut

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Shrivastava, Garima, Hamid A. Bakshi, Alaa A. Aljabali, et al. "Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System." Current Drug Delivery 17, no. 2 (2020): 101–11. http://dx.doi.org/10.2174/1567201817666200106104332.

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Background: Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing singlestranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed apta

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Choi, Woncheol, Hyunsik Jung, Kyungsuk Kim, et al. "Rhus vernicifluaStokes against Advanced Cancer: A Perspective from the Korean Integrative Cancer Center." Journal of Biomedicine and Biotechnology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/874276.

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Active anticancer molecules have been searched from natural products; many drugs were developed from either natural products or their derivatives following the conventional pharmaceutical paradigm of drug discovery. However, the advances in the knowledge of cancer biology have led to personalized medicine using molecular-targeted agents which create new paradigm. Clinical benefit is dependent on individual biomarker and overall survival is prolonged through cytostatic rather than cytotoxic effects to cancer cell. Therefore, a different approach is needed from the single lead compound screening

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Doeleman, Martijn J. H., Erik M. van Maarseveen, and Joost F. Swart. "Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis." Rheumatology 58, no. 10 (2019): 1839–49. http://dx.doi.org/10.1093/rheumatology/kez030.

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Abstract Objective The clinical impact of anti-drug antibodies (ADAbs) in paediatric patients with JIA remains unknown. This systematic review and meta-analysis aimed to summarize the prevalence of ADAbs in JIA studies; investigate the effect of ADAbs on treatment efficacy and adverse events; and explore the effect of immunosuppressive therapy on antibody formation. Methods PubMed, Embase and the Cochrane Library were systematically searched to identify relevant clinical trials and observational studies that reported prevalence of ADAbs. Studies were systematically reviewed in accordance with

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Mitikiri, Nirupama Devi, Emily S. Reese, Arif Hussain, et al. "Heterogeneity of treatment effects (HTE) in stage IV prostate cancer (S4PC)." Journal of Clinical Oncology 31, no. 6_suppl (2013): 180. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.180.

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180 Background: HTE occurs when individual patient factors modify a treatment’s effect on health outcomes in a non-random and predictable manner. HTE results in specific subgroups of patients in the same study having different responses to the same treatment due to interactions between their individual factors and the treatment. Methods: A systematic literature review was conducted of articles published between 1946 and 2011. Inclusion criteria required that articles examine the impact of HTE factors on survival outcomes (OS, TTP, PFS) or QOL among S4PC patients, in the context of a specific t

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Collins, Anne T., and Shona H. Lang. "A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine." PeerJ 6 (November 21, 2018): e5981. http://dx.doi.org/10.7717/peerj.5981.

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Patient-derived xenograft (PDX) models are increasingly being used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic review to identify all original publications describing the derivation of PDX models of colon, prostate, breast and lung cancer. Validity was defined as the ability to recapitulate the disease of interest. The study protocol was registered with the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studi

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Aksenenko, M. B., A. V. Komina, N. V. Palkina, et al. "TRANSCRIPTOMIC ANALYSIS OF MELANOMA CELLS EXTRACTED FROM DIFFERENT SITES OF THE PRIMARY TUMOR." Siberian journal of oncology 17, no. 4 (2018): 59–66. http://dx.doi.org/10.21294/1814-4861-2018-17-4-59-66.

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Introduction.Intratumor heterogeneity is a characteristic feature for most malignant tumors, including cutaneous melanoma. This property represents one of the main obstacles for effective targeted therapy, due to the different sensitivity to chemotherapeutic agents on various tumor cells subclones. Treatment of malignant tumors requires an individual approach to choose the most appropriate treatment regimen.The purposeof the study was to evaluate differences in melanoma tissue samples obtained from different parts of one patient’s primary tumor at the transcriptomic level.Material and Methods.

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Artieta-Pinedo, Isabel, Carmen Paz-Pascual, Paola Bully, and Maite Espinosa. "Design of the Maternal Website EMAeHealth That Supports Decision-Making During Pregnancy and in the Postpartum Period: Collaborative Action Research Study." JMIR Formative Research 5, no. 8 (2021): e28855. http://dx.doi.org/10.2196/28855.

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Background Despite the benefit maternal education has for women, it needs new tools to increase its effectiveness and scope, in tune with the needs of current users. Objective We attempted to develop a multifunctional personalized eHealth platform aimed at the self-management of health in relation to maternity, which can be considered a flexible and adaptable maternal education tool. Methods The International Patient Decision Aid Standards (IPDAS) were applied. A website prototype was developed for implementation in the public health system using a collaborative action research process, in whi

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Qadi, Olla, Nakawala Lufumpa, Nicola Adderley, Danai Bem, Tom Marshall, and Farina Kokab. "Patients’ and health professionals’ attitudes and perceptions towards the initiation of preventive drugs for primary prevention of cardiovascular disease: a systematic review of qualitative studies." BJGP Open 4, no. 5 (2020): bjgpopen20X101087. http://dx.doi.org/10.3399/bjgpopen20x101087.

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BackgroundStatins and antihypertensive agents are recommended for primary prevention of cardiovascular disease (CVD), but they are not always prescribed to eligible patients.Design & settingA systematic review of qualitative studies.AimTo explore health professionals’ and patients’ attitudes towards cardiovascular preventive drugs.MethodMEDLINE, Embase, PsychINFO, CINAHL, ASSIA, HMIC, Conference Proceedings Citation Index, and Open Grey were searched for studies of qualitative design without restrictions on date or language. Two reviewers performed study selection, data extraction, quality

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Bucy, Taylor, John Zoscak, Motomi Mori, Vinayak Prasad, and Uma Borate. "Proportion of Patients with FLT3 Positive AML Required to Enroll on Clinical Trials to Satisfy the Recruitment Needs of FLT3 Inhibitor Trials: Are We Running out of Patients?" Blood 132, Supplement 1 (2018): 713. http://dx.doi.org/10.1182/blood-2018-99-120142.

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Abstract Introduction. The push for personalized medicine in oncology has generated an influx of therapies targeting similar pathways, despite only 5% of clinically tested agents receiving FDA approval (Mattina 2017). Acute myeloid leukemia (AML) is a malignancy where identification of prognostically significant mutations suggests growing potential for therapeutic inhibition. FMS-like tyrosine kinase 3 (FLT3) mutations are deemed one of few "actionable" mutations and include 30% of de novo AML cases (25% ITD, 5% TKD) (Garcia 2017; Fathi 2016). In 2017 there will be approximately 21000 new AML

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Heakal, Yasser, Mark Kester, and Scott Savage. "Vemurafenib (PLX4032): An Orally Available Inhibitor of Mutated BRAF for the Treatment of Metastatic Melanoma." Annals of Pharmacotherapy 45, no. 11 (2011): 1399–405. http://dx.doi.org/10.1345/aph.1q363.

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Objective: To summarize the preclinical and clinical data on vemurafenib, approved by the Food and Drug Administration (FDA) on August 17, 2011, and discuss the drug's clinical advantages and limitations. Data Sources: An English-language literature search of MEDLINE/PubMed (1966-August 2011), using the terms PLX4032, RG7204, R05185426, vemurafenib, and metastatic melanoma, was conducted. In addition, information and data were obtained from meeting abstracts, clinical trial registries, and news releases from the FDA. Study Selection and Data Extraction: All relevant published articles and abst

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Bossi, Paolo, Paolo Delrio, Annalisa Mascheroni, and Michela Zanetti. "The Spectrum of Malnutrition/Cachexia/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review." Nutrients 13, no. 6 (2021): 1980. http://dx.doi.org/10.3390/nu13061980.

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Nutritional status in oncological patients may differ according to several modifiable and non-modifiable factors. Knowledge of the epidemiology of malnutrition/cachexia/sarcopenia may help to manage these complications early in the course of treatment, potentially impacting patient quality of life, treatment intensity, and disease outcome. Therefore, this narrative review aimed to critically evaluate the current evidence on the combined impact of tumor- and treatment-related factors on nutritional status and to draw some practical conclusions to support the multidisciplinary management of maln

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van Mackelenbergh, Stroes, Spijker, et al. "Clinical Trials Targeting the Stroma in Pancreatic Cancer: A Systematic Review and Meta-Analysis." Cancers 11, no. 5 (2019): 588. http://dx.doi.org/10.3390/cancers11050588.

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The tumor microenvironment plays an important role in the initiation and progression of pancreatic adenocarcinoma (PDAC). In this systematic review, we provide an overview of clinical trials with stroma-targeting agents. We systematically searched MEDLINE/PubMed and the EMBASE database, using the PRISMA guidelines, for eligible clinical trials. In total, 2330 records were screened, from which we have included 106 articles. A meta-analysis could be performed on 51 articles which describe the targeting of the vascular endothelial growth factor (VEGF) pathway, and three articles which describe th

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Schaap, Mirjam J., Finola M. Bruins, Xuehui He, et al. "Skin Surface Protein Detection by Transdermal Analysis Patches in Pediatric Psoriasis." Skin Pharmacology and Physiology 34, no. 5 (2021): 271–80. http://dx.doi.org/10.1159/000516110.

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<b><i>Introduction:</i></b> Transdermal analysis patches (TAPs) noninvasively measure soluble proteins in the stratum corneum. Ultimately, such local protein profiles could benefit the search for biomarkers to improve personalized treatment in psoriasis. This study aimed to explore the patient friendliness and protein detection by TAP in pediatric psoriasis in daily clinical practice. <b><i>Methods:</i></b> In this observational study, TAPs measuring CXC chemokine ligand (CXCL)-1/2, CC chemokine ligand (CCL)-27, interleukin (IL)-1RA, IL-23, IL-1α

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Hoell, Jessica I., Sebastian Ginzel, Cornelia Eckert, et al. "Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia Relapsing after Allogeneic Stem Cell Transplantation." Blood 128, no. 22 (2016): 601. http://dx.doi.org/10.1182/blood.v128.22.601.601.

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Abstract The prognosis of children with acute lymphoblastic leukemia (ALL) relapsing following allogeneic hematopoietic stem cell transplantation (allo-SCT) is still dismal. Within the framework of the ALL-REZ BFM 2002/ALL-SZT BFM 2003 trials, we performed whole-exome sequencing (WES) of ten patients relapsing after allo-SCT with the aim to thoroughly characterize the spectrum of acquired mutations and to identify potentially druggable targets, thus laying the ground for future personalized treatment strategies. Patients' age at initial diagnosis ranged from <12 months to 10 years. Two pati

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Ahmad, Muhaddis Ejaz, Muhammad Abdullah Yousaf, Abdul Rafae, et al. "Melphalan Based Regimens for Treatment of Newly Diagnosed Amyloidosis, Lessons from Clinical Literature: A Systematic Review." Blood 134, Supplement_1 (2019): 5561. http://dx.doi.org/10.1182/blood-2019-127192.

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Introduction: Melphalan causes cross linkage between DNA, causes cytotoxicity in both dividing and non-dividing tumor cells. Our objective is to analyze and summarize the published literature for the efficacy of melphalan based regimen used for the treatment of newly diagnosed Amyloidosis (ND-AL). Methods: We performed a comprehensive literature search on articles following PRISMA guidelines. Beginning with articles published after June 2006, we used databases like PubMed, Embase, Clinicaltrials.gov, Cochrane Library and Web of Science. Total 649 articles were identified initially and after de

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Preddie, Martha Ingrid. "Canadian Public Library Users are Unaware of Their Information Literacy Deficiencies as Related to Internet Use and Public Libraries are Challenged to Address These Needs." Evidence Based Library and Information Practice 4, no. 4 (2009): 58. http://dx.doi.org/10.18438/b8sp7f.

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A Review of:  Julien, Heidi and Cameron Hoffman. “Information Literacy Training in Canada’s Public Libraries.” Library Quarterly 78.1 (2008): 19-41.  Objective – To examine the role of Canada’s public libraries in information literacy skills training, and to ascertain the perspectives of public library Internet users with regard to their experiences of information literacy.   Design – Qualitative research using semi-structured interviews and observations.   Setting – Five public libraries in Canada.   Subjects – Twenty-eight public library

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Budge, Eleanor J., Muhammad AA Khalil Allam, Imogen Mechie, Marie Scully, Obi Agu, and Chung Sim Lim. "Venous malformations: Coagulopathy control and treatment methods." Phlebology: The Journal of Venous Disease, December 6, 2020, 026835552097291. http://dx.doi.org/10.1177/0268355520972918.

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Venous malformations (VMs) are ectatic channels which arise as a result of vascular dysmorphogenesis, commonly caused by activating mutations in the endothelial tyrosine kinase receptor (TIE2)/phosphatidylinositol 3-kinase (PI3Kinase) pathway. With a prevalence of 1% in the general population, and a diverse clinical presentation depending on site, size and tissue involvement, their treatment requires a personalised and multidisciplinary approach. Larger lesions are complicated by local intravascular coagulopathy (LIC) causing haemorrhagic and/or thrombotic complications which can progress to d

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Zhu, Dengya, Shastri Lakshman Nimmagadda, Torsten Reiners, and Amit Rudra. "An Integrated Search Framework for Leveraging the Knowledge-Based Web Ecosystem." Australasian Journal of Information Systems 24 (October 19, 2020). http://dx.doi.org/10.3127/ajis.v24i0.2331.

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The explosion of information constrains the judgement of search terms associated with Knowledge-Based Web Ecosystem (KBWE), making the retrieval of relevant information and its knowledge management challenging. The existing information retrieval (IR) tools and their fusion in a framework need attention, in which search results can effectively be managed. In this article, we demonstrate the effective use of information retrieval services by a variety of users and agents in various KBWE scenarios. An innovative Integrated Search Framework (ISF) is proposed, which utilises crawling strategies, we

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Oksana, Movchan. "Molecular Aspects of Cancer Research Endometrium – The Prospect of Personalized Treatment." Journal of Pharmaceutical Research International, September 6, 2021, 346–56. http://dx.doi.org/10.9734/jpri/2021/v33i43a32496.

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Aims: Endometrial cancer is the most common gynaecological cancer, and there is a growing interest in identifying the molecular pathways involved and developing molecular-targeted treatment to prevent it. Present study was aimed to give an overview of the molecular processes involved in endometrial cancer development and treatment options. Methods: We conducted a comprehensive systematic literature review and meta-analysis. For that purpose, PubMed database was searched for related studies till June 2021 and a through selection process was adopted to select the eligible studies. Re

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Oz, Merve Demirbugen, Fezile Ozdemir, and Halit Sinan Suzen. "The influence of genetic variations and drug interactions based on metabo-lism of antidepressants and anticonvulsants." Current Drug Metabolism 21 (November 25, 2020). http://dx.doi.org/10.2174/1389200221999201125211058.

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Background:: Antidepressant (AD) and anticonvulsants (AC) medications are widely prescribed to treat neuro-psychiatric disorders and a broad range of other comorbidities. Interpatient variability in response to a given drug is a large challenge in psychiatry and neurology. Clinically similar patient’s often experience vastly different outcomes (higher or lower levels than the therapeutic range and/or adverse effects) from the same drug at similar doses. The variability in drug response is highly complex and can be attributed to the polymedication, genetic polymorphisms modulating drug-metaboli

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Fong, Winnie, and Kenneth K. W. To. "Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy." Recent Patents on Anti-Cancer Drug Discovery 15 (January 6, 2021). http://dx.doi.org/10.2174/1574892815666210106111012.

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Background: Drug repurposing is emerging as an attractive strategy with lower attrition rate, lower cost and shorter timeframe than traditional drug discovery methods. Chloroquine (CQ) and its analogs are old drugs originally indicated for malaria treatment. Serendipitous discovery in early years revealed its anti-inflammatory properties, thus allowing its repositioned use in autoimmune diseases. Recent evidence also suggested its potential therapeutic use for anticancer therapy. Objective: This article reviews the molecular mechanisms, clinical evaluation and recent patents of CQ analogs in c

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Fong, Winnie, and Kenneth K. W. To. "Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy." Recent Patents on Anti-Cancer Drug Discovery 15 (January 6, 2021). http://dx.doi.org/10.2174/1574892815666210106111012.

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Background: Drug repurposing is emerging as an attractive strategy with lower attrition rate, lower cost and shorter timeframe than traditional drug discovery methods. Chloroquine (CQ) and its analogs are old drugs originally indicated for malaria treatment. Serendipitous discovery in early years revealed its anti-inflammatory properties, thus allowing its repositioned use in autoimmune diseases. Recent evidence also suggested its potential therapeutic use for anticancer therapy. Objective: This article reviews the molecular mechanisms, clinical evaluation and recent patents of CQ analogs in c

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