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1
Rofé, Jessica. "Peripheral Detention, Transfer, and Access to the Courts." Michigan Law Review, no. 122.5 (2024): 867. http://dx.doi.org/10.36644/mlr.122.5.peripheral.
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In the last forty years, immigration detention in the U.S. has grown exponentially, largely concentrated in the southern states and outside of the country’s metropoles. In turn, federal immigration officials routinely transfer immigrants from their communities to remote jails and prisons hundreds, if not thousands, of miles away, often in jurisdictions where the law is more favorable to the government. These transfers are conducted without notice or process and frequently occur on weekends or in the predawn hours, when offices are closed and interested parties are lucky to access voicemail. Federal immigration officials’ use of peripheral detention and transfer significantly affects immigrants’ access to the courts and their ability to raise detention challenges. Lurking beneath these issues lies a seemingly technical Supreme Court decision relied on by the government to seek dismissal of habeas actions filed by immigrant petitioners who have been ferried to faraway jails and prisons. In Rumsfeld v. Padilla, the Supreme Court held that the “default rule” in a habeas action challenging present physical confinement is that it must be brought in a petitioner’s “district of confinement” and that a petitioner can only name a single respondent: their “immediate custodian.” However, the history and development of immigration detention and of the habeas statute offer important insights into present debates about the primacy of Padilla in the context of transfer. A mining of these histories unravels the foundational premises on which Padilla relied and encourages us to question mechanical rules that silo immigrant habeas actions in faraway fora, away from evidence, witnesses, community, counsel, and the events giving rise to the detentions themselves.
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Bowden, Jamie, David Whitaker, and Matt J. Dunn. "The role of Peripheral Vision in the Flashed Face Distortion Effect." Perception 48, no. 1 (December 19, 2018): 93–101. http://dx.doi.org/10.1177/0301006618817419.
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The flashed face distortion effect is a phenomenon whereby images of faces, presented at 4–5 Hz in the visual periphery, appear distorted. It has been hypothesized that the effect is driven by cortical, rather than retinal, components. Here, we investigated the role of peripheral viewing on the effect. Normally sighted participants viewed the stimulus peripherally, centrally, and centrally with a blurring lens (to match visual acuity in the peripheral location). Participants rated the level of distortion using a Visual Analogue Scale. Although optical defocus did have a significant effect on distortion ratings, peripheral viewing had a much greater effect, despite matched visual acuity. We suggest three potential mechanisms for this finding: increased positional uncertainty in the periphery, reduced deployment of attention to the visual periphery, or the visual crowding effect.
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Yufereva, Olena V. "PERIPHERAL WRITING AND WRITING ON THE PERIPHERY IN TRAVELOGUES BY JAY NORWOOD DARLING." Alfred Nobel University Journal of Philology 1, no. 27 (June 3, 2024): 72–84. http://dx.doi.org/10.32342/2523-4463-2024-1-27-5.
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The article is devoted to the little-known literary work of the American cartoonist Jay Norwood Darling. The current study was conducted on the travelogues “Ding Goes to Russia” (1932) and “The Cruise of the Bouncing Betsy. A Trailer Travelogue” (1937). This article aims to reveal and contextualize the features of J.N. Darling’s travel texts as peripheral genres. The main objective of this work is to analyze the deep structures of the travelogues chronotope, based on which the hypothesis will be put forward. Its essence is that the intensity of the crisis time experience in different spaces and through these spaces modifies the involved genre clichés, giving rise to a tragic (for Soviet space) and optimistic (for American space) premonition. The research methodology is based on the study of the interaction between the centre and periphery of the literary system, in particular, the concept of “semiosphere” formulated by Yu. Lotman. Genre analysis includes comparative and contextual methods of studying texts. The cultural-historical method deepens the understanding of the context of Darling’s literary work. Particularly, it is used to discover the historical and social factors that impact the peculiarities of others and one’s own world perception and image reconstruction. Genre analysis of travelogues with various graphic components, including caricatures, involves an intermedia method of studying the semantic connections between visual and verbal in travelogues. The examination of Darling’s travelogues “Ding Goes to Russia” and “The Cruise of the Bouncing Betsy. A Trailer Travelogue”, which inherited different genre traditions, revealed their conceptual and poetic affinities. In both texts, the author investigates the common issues of civilization and its advancement, as well as the significance of technological progress for a human being. The features of the unmanifested future or hidden phenomena of the present are felt more strongly at a distance from the centre, at the intersection of transit paths. Geography in these travels is perceived through anthropological optics, implemented, among other things, through the concepts of the mutual influence of society and space in an unstable world. The experience of alienation is constructed through images of places displayed identically in both travelogues. In Darling’s travelogues, places outside of symbolic meaning come to the fore of the spatio-temporal structure. According to the concept of M. Auger, their features can be attributed to non-places. The key features of the chronotope of both travelogues are the peripheralization of space, the transformation of places into space, and the related process, the representation of non-places. The caricaturists’ texts exhibit genre peripherality through the dual nature of their poetic codes. Behind the secondary nature of the genre constructions of both texts, one cannot help but see individual searches reflected in the unique role and methods of spatial metaphors and imaginary topoi explication. Their semantic and visual density force us to recall and re-estimate the factual writing of the cartoonist in the context of future genre development.
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Rivera, Heidi M., and Lisa A. Eckel. "Activation of Central, But Not Peripheral, Estrogen Receptors Is Necessary for Estradiol’s Anorexigenic Effect in Ovariectomized Rats." Endocrinology 151, no. 12 (November 3, 2010): 5680–88. http://dx.doi.org/10.1210/en.2010-0731.
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Estradiol appears to exert its anorexigenic effect by activating nuclear estrogen receptors (ERs), which are expressed widely in peripheral tissues and in the brain. Here, we used ICI-182,780 (ICI), a pure antiestrogen with limited ability to cross the blood-brain barrier, to assess the relative involvement of peripheral vs. central ERs to estradiol’s anorexigenic effect. Food intake was measured after peripheral (sc) administration of ICI or vehicle in ovariectomized rats treated with acute injections of estradiol benzoate and sesame oil over a 2-wk period. Uterine weight was assessed as a biological assay of peripheral ER activation. In a second experiment, food intake was measured after central (lateral ventricular) administration of ICI or vehicle in ovariectomized rats receiving acute injections of estradiol benzoate and oil over a period of 10 d. In order to assess the possible spread of ICI from the brain to the periphery, vaginal cytology samples were examined as a biological assay of peripheral ER activation. Peripherally administered ICI failed to attenuate estradiol’s anorexigenic effect at a dose that was sufficient to block estradiol’s uterotrophic effect. This suggests that peripheral activation of ERs is not necessary for estradiol’s anorexigenic effect. Although central infusion of 4 nm ICI blocked estradiol’s anorexigenic effect, it did not attenuate estradiol’s ability to increase the presence of cornified cells in vaginal cytology samples, suggesting that ICI did not leak into the periphery. We conclude that activation of central, but not peripheral, ERs is necessary for estradiol’s anorexigenic effect.
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Simin, Dragana, Dragana Milutinović, Vesna Turkulov, and Svetlana Simić. "Peripheral nerve injury related to peripheral intravenous therapy." Inspirium, no. 14 (2015): 19–21. http://dx.doi.org/10.5937/insp1513019s.
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Introduction: The objective of the current study was to present data on peripheral nerve injury related to peripheral intravenous therapy obtained through the use of empirical studies and analysis. Materials and Methods: To detect empirical studies, we developed search strategies for use in Medline electronic database, using only related keywords, based on MeSH terms: peripheral nerve injuries, peripheral nerve damage, peripheral intravenous therapy, venipuncture, periphera lintravenous cannulation. The studies included in this analysis were published in English. Results: The likelihood of peripheral nerve injury related to venipuncture and peripheral intravenous cannulation is often citedin the research literature. However, there have been more frequent reports of nerve injury consequent on venepuncture in comparison to rare case reports of peripheral nerve injury from intravenous cannulation. Based on Seddon's classification of nerve injuries, a review of the literature shows incidence of all three types of injury. Conclusions: Peripheral intravenous therapy is the most common procedures performed by nurses in their everyday clinical practice, can cause different types of damage to the peripheral nerves.
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Fan, Xiaoxu, Lan Wang, Hanyu Shao, Daniel Kersten, and Sheng He. "Temporally flexible feedback signal to foveal cortex for peripheral object recognition." Proceedings of the National Academy of Sciences 113, no. 41 (September 26, 2016): 11627–32. http://dx.doi.org/10.1073/pnas.1606137113.
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Recent studies have shown that information from peripherally presented images is present in the human foveal retinotopic cortex, presumably because of feedback signals. We investigated this potential feedback signal by presenting noise in fovea at different object–noise stimulus onset asynchronies (SOAs), whereas subjects performed a discrimination task on peripheral objects. Results revealed a selective impairment of performance when foveal noise was presented at 250-ms SOA, but only for tasks that required comparing objects’ spatial details, suggesting a task- and stimulus-dependent foveal processing mechanism. Critically, the temporal window of foveal processing was shifted when mental rotation was required for the peripheral objects, indicating that the foveal retinotopic processing is not automatically engaged at a fixed time following peripheral stimulation; rather, it occurs at a stage when detailed information is required. Moreover, fMRI measurements using multivoxel pattern analysis showed that both image and object category-relevant information of peripheral objects was represented in the foveal cortex. Taken together, our results support the hypothesis of a temporally flexible feedback signal to the foveal retinotopic cortex when discriminating objects in the visual periphery.
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Smith, Howard. "Peripherally-Acting Opioids." Pain Physician 2s;11, no. 3;2s (March 14, 2008): S121—S132. http://dx.doi.org/10.36076/ppj.2008/11/s121.
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Opioids are broad-spectrum analgesics with potent pain-relieving qualities but also with potential adverse effects related to both short-term and long-term therapy. Researchers have attempted to alter existing opioid analgesics, utilize different routes/ formulations, or combine opioid analgesics with other compounds in efforts to improve analgesia while minimizing adverse effects. Exogenous opioids, administered in efforts to achieve analgesia, work by mimicking the actions of endogenous opioids. Endogenous opioids and their receptors are located in the brain (supraspinal areas), spinal cord, and periphery. Although opioids and opioid receptors in the brain and spinal cord have received much attention over many years, peripheral endogenous opioid analgesic systems have only been extensively studied during the past decade. It has been known since 1990 that following injection into the rodent hindpaw, d-Ala2 , N-Me-Phe4 , Gly5 -ol-enkephalin (DAMGO) [a muopioid receptor agonist] probably exerts its antinociceptive effects locally, since the doses administered are too low to have an effect in the central nervous system (CNS). This notion has been supported by the observation that the quaternary compound morphine methyliodide, which does not as readily cross the bloodbrain barrier and enter the CNS, produced antinociception following intradermal administration into the hindpaw, but not when the same dose was administered systemically (subcutaneously at a distant site). With a growing appreciation of peripheral endogenous opioids, peripheral endogenous opioid receptors, and peripheral endogenous opioid analgesic systems, investigators began growing hopeful that it may be possible to achieve adequate analgesics while avoiding unwanted central untoward adverse effects (e.g. respiratory depression, somnolence, addiction). Peripherally-acting opioids, which capitalize on peripheral endogenous opioid analgesic systems, may be one potential future strategy which may be utilized in efforts to achieve potent analgesia with minimal side effects. Key words: Pain, opioids, immune cells, peripherally-acting opioids (PAO), leukocytes, inflammatory pain, peripheral analgesia
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Snowden, R. J. "Orientation Channels in the Peripheral Visual Field." Perception 26, no. 1_suppl (August 1997): 362. http://dx.doi.org/10.1068/v970155.
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Peripheral vision has been modelled as a coarser version of foveal vision. Thus visual behaviour elicited by, say, a 2 cycles deg−1 grating imaged foveally would be reproduced in the periphery by a lower spatial frequency (say 1 cycle deg−1). Tuning for orientation is broader at a low than high spatial frequency (Snowden, 1992 Vision Research32 1965 – 1974). Taken together this leads to the surprising prediction that, given a particular spatial frequency, tuning for orientation is narrower for peripheral viewing! In this study it has also been found that orientation tuning broadens with increasing temporal frequency, but the opposite relationship has been reported for peripheral vision (Sharpe and Tolhurst, 1973 Vision Research13 2103 – 2112). Orientation bandwidths were measured by the method of selective adaptation following the procedures and analysis techniques described by Snowden (1991 Proceedings of the Royal Society of London, Series B246 53 – 59). The results show that orientation bandwidths did indeed narrow as a stimulus was imaged more peripherally, so that its bandwidth in the peripheral retina could be half that of the fovea. However, at a greater eccentricity, bandwidths broadened once more. The results were not influenced by the contrast of the adaptation pattern eliminating visibility as a possible explanation. Increasing temporal frequency broadened orientation bandwidth at all eccentricities.
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Venturino, Michael, and Edward J. Rinalducci. "Peripheral Vision and Peripheral Displays." Proceedings of the Human Factors Society Annual Meeting 30, no. 6 (September 1986): 599–600. http://dx.doi.org/10.1177/154193128603000621.
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Technological advances have signi-ficantly altered the nature of the man-machine inter-face. Notable changes include: 1) a redefinition of the role of the human from that of a manual operator to a monitor/manager of complex systems; and 2) the availability of large amounts of data, presented or updated at rapid rates. As a result of such changes, the human operator must monitor, integrate, evaluate, and utilize continually changing information from a large number of spatially separated displays. Such demands require complex scanning patterns among numerous displays, and maintaining large amounts of information in working memory. These requirements and demands often overload the human's limited processing capabilities, and lead to degraded performance and increased probability of error. One possible solution to this propagation of displays and consequent information overload is to make more efficient use of human visual capabilities by offloading some types of information from foveal vision to peripheral vision. If appropriate types of information are presented to each aspect of vision (foveal and peripheral), then the human operator's bandwidth of information intake may be usefully increased. However, significant issues must be addressed before attempts are made to design peripheral displays. Such issues may be grouped into three categories: 1) determine the characteristics of peripheral vision relevant to display design (e.g., luminance sensitivity, contrast sensitivity, and acuity); 2) determine the characteristics of peripheral information processing (e.g., the costs and benefits of covert orienting of attention, the effects of foveal load on peripheral processing and vice-versa, and events in peripheral vision that cause a saccade); and 3) determine what types of information structure provide useful information in peripheral vision, which would indicate what types of information should be displayed in peripheral vision. The answers to these issues will provide data that may help determine whether it is feasible to display useable information to both foveal and peripheral vision, and provide guidelines for the design of peripheral displays. The purpose of this symposium is to address theoretical and applied issues of peripheral vision. The description and evaluation of the properties and characteristics of peripheral vision will serve as fundamental knowledge in determining the feasibility and design of peripheral displays. The symposium will be empirical in nature, with the participants presenting experimental data relevant to the above issues.
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Mazal, Zdeněk. "Peripheral Exudative Heamorrhagic Chorioretinopathy." Czech and Slovak Ophthalmology 75, no. 2 (March 7, 2019): 80–84. http://dx.doi.org/10.31348/2019/2/4.
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Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is relatively rare and especially less known and therefore less often diagnosed condition of the retina periphery predominantly in patients of higher age. Usually temporal periphery is affected. The finding is bilateral in approximately 30 %. Clinically it manifests by multibulbar prominences in periphery, which can sometimes resemble choroidal melanoma. It concerns exudations and hemorrhages under retina (sub-retinal) or under retinal pigment epithelium (sub-RPE). Within weeks or months hemorrhagy is resorbed and flattened and chorioretinal atrophy of various grade remains in affected area, sometimes combined with retinal fibrosis. If the affected area remains limited to the periphery, the central visual acuity does not have to be reduced. Affection is considered to be peripheral form of wet age-related macular degeneration or peripheral form of idiopathic polypoidal choroidal vasculopathy. By differential diagnosis is necessary to exclude especially malignant choroidal melanoma and choroidal detachment. Case report: Own case of 83 years old patient with bilateral PEHCR is described and photo documented. Creation of new prominence - fresh bleeding under retina and RPE in superior periphery – had been captured. Photo documentation of lesion in early stage and in stage of resorbtion after several weeks. Affected areas remained limited to periphery and did not have influence on central vision. That was influenced by degeneration of macula and vitreomacular traction syndrome with distinct epiretinal membrane. Conclusion: PEHCR is less frequent or less diagnosed condition of the retina periphery in old patients. Ongoing exudation and sub-retinal or sub-RPE bleeding. Within weeks heals with chorioretinal scars and subretinal fibrosis. Central vision does not have to be damaged, if lesions do not spread to macula.
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Merrill, Gary. "Caffeine and Peripheral Blood Flow." Clinical Medical Reviews and Reports 2, no. 02 (February 24, 2020): 01–04. http://dx.doi.org/10.31579/2690-8794/009.
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Caffeine is the drug of choice for adults of the world. It is commonly found in the favorite beverages they consume such as coffee, energy drinks, soft drinks and tea. The caffeine molecule is a decorative sculpture that helps visitors identify the recently-constructed Chemistry and Chemical Biology Building on the Busch Campus of Rutgers University, Piscataway, New Jersey.
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S. Behera, S. Singh, and M. Sar. "PERIPHERAL ENTHESOPATHY: AN OSTEOLOGICAL STUDY." International Journal of Anatomy and Research 8, no. 3.2 (August 10, 2020): 7654–59. http://dx.doi.org/10.16965/ijar.2020.178.
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Takım, Uğur, and Hacer Akgül Ceyhun. "VALPROATE-QUETIAPINE INDUCED PERIPHERAL EDEMA." PSYCHIATRIA DANUBINA 35, no. 3 (October 23, 2023): 445–47. http://dx.doi.org/10.24869/psyd.2023.445.
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Mikaelian, H. H. "Psychology of Computer Use: IV. Effects of Video Display Units on Fundamental Visual Processes: Temporal Resolution." Perceptual and Motor Skills 66, no. 3 (June 1988): 951–62. http://dx.doi.org/10.2466/pms.1988.66.3.951.
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Measures of two-pulse resolution (2PR) using foveally and peripherally viewed targets were obtained before and after reading videotext and print. Three pulse durations (25, 250, and 300 msec) were used. The results showed that (a) 2PR on the fovea is about a fourth of that on the periphery, (b) peripheral 2PR increases following reading videotext, and (c) no appreciable effects occur following reading print.
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Nickell, Kevin, and Timothy B. Boone. "PERIPHERAL NEUROPATHY AND PERIPHERAL NERVE INJURY." Urologic Clinics of North America 23, no. 3 (August 1996): 491–500. http://dx.doi.org/10.1016/s0094-0143(05)70328-1.
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Kirsch, Wladimir, Roland Pfister, and Wilfried Kunde. "On Why Objects Appear Smaller in the Visual Periphery." Psychological Science 31, no. 1 (December 12, 2019): 88–96. http://dx.doi.org/10.1177/0956797619892624.
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An object appears smaller in the periphery than in the center of the visual field. In two experiments ( N = 24), we demonstrated that visuospatial attention contributes substantially to this perceptual distortion. Participants judged the size of central and peripheral target objects after a transient, exogenous cue directed their attention to either the central or the peripheral location. Peripheral target objects were judged to be smaller following a central cue, whereas this effect disappeared completely when the peripheral target was cued. This outcome suggests that objects appear smaller in the visual periphery not only because of the structural properties of the visual system but also because of a lack of spatial attention.
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Bayer, Allison L., Aixin Yu, and Thomas R. Malek. "Thymic IL-2R expression is sufficient for production of CD4+CD25+ Foxp3+ T regulatory cells (95.5)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S177. http://dx.doi.org/10.4049/jimmunol.178.supp.95.5.
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Abstract CD4+CD25+ FoxP3+ Treg cells critically depend on IL-2, but the contribution of IL-2 to development of Treg cells in the thymus versus controlling their homeostasis in the periphery is unresolved. We addressed this issue using models where IL-2R activity was blocked in the thymus and periphery or only in the periphery. We found that IL-2/IL-2R interaction is active and essential in the thymus by promoting Treg cell expansion and upregulation of Foxp3 and CD25 to normal levels. This thymic signal gave rise to peripheral Treg cells with impaired IL-2-dependent STAT5 activation, yet they persisted in the periphery and suppressed autoimmunity without continual thymic output. Thus, thymic IL-2R function represents one important aspect for Treg cell development. Peripheral Treg cells with impaired IL-2R signaling exhibited slower growth and death rates as assessed by BrdU uptake in vivo and their suppressive activity was slightly lower in vitro. Importantly, by following donor Treg cells in mixed thymic and bone marrow chimeric mice, we found that WT Treg cells dominated peripheral immune tissue compared to Treg cells with impaired peripheral IL-2 signaling. Thus, IL-2 is a dominant mechanism controlling the number of thymic and peripheral Treg cells, although in a non-competitive setting, peripheral Treg cells with minimal IL-2R signaling persist and control autoimmunity. (Supported by the NIH)
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Kimmig, Sonja, Grzegorz K. Przybylski, Christian A. Schmidt, Katja Laurisch, Beate Möwes, Andreas Radbruch, and Andreas Thiel. "Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood." Journal of Experimental Medicine 195, no. 6 (March 18, 2002): 789–94. http://dx.doi.org/10.1084/jem.20011756.
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During ageing thymic function declines and is unable to meet the demand for peripheral T helper (Th) cell replenishment. Therefore, population maintenance of naive Th cells must be at least partly peripherally based. Such peripheral postthymic expansion of recent thymic emigrants (RTEs) during ageing consequently should lead to loss or dilution of T cell receptor excision circles (TRECs) from a subset of naive T cells. We have identified two subsets of naive Th cells in human adult peripheral blood characterized by a striking unequal content of TRECs, indicating different peripheral proliferative histories. TRECs are highly enriched in peripheral naive CD45RA+ Th cells coexpressing CD31 compared with peripheral naive CD45RA+ Th cells lacking CD31 expression, in which TRECs can hardly be detected. Furthermore we show that CD31−CD45RA+ Th cells account for increasing percentages of the naive peripheral Th cell pool during ageing but retain phenotypic and functional features of naive Th cells. As CD31 is lost upon T cell receptor (TCR) engagement in vitro, we hypothesize that TCR triggering is a prerequisite for homeostatically driven peripheral postthymic expansion of human naive RTEs. We describe here the identification of peripherally expanded naive Th cells in human adult blood characterized by the loss of CD31 expression and a highly reduced TREC content.
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Zwahlen, Helmut T., and Thomas Schnell. "Conspicuity Advantage of Fluorescent Color Targets in the Field." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 40, no. 18 (October 1996): 915–18. http://dx.doi.org/10.1177/154193129604001810.
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Daytime conspicuity of fluorescent and non-fluorescent color targets was investigated in the field against a green background in terms of visual detection and recognition, as a function of the peripheral angle and the target size. Two groups of 9 young, healthy subjects each were used. The colors white, blue, green, red, fluorescent red, fluorescent yellow-green, yellow, fluorescent yellow, orange, fluorescent orange were presented for 2 seconds at a radial distance of 30m under the peripheral viewing angles of 10°, 20°, 30° for group 1, and 30°, 40°, 50° for group 2. The target sizes 0.076m x 0.152m, 0.114m x 0.229m, and 0.152m x 0.305m were used in group 1, and 0.114m x 0.229m, 0.152m x 0.305m, and 0.229m x 0.457m were used in group 2. Fluorescent color targets (especially fluorescent yellow-green) were better peripherally detected than the non-fluorescent color targets. White, blue, and green were better recognized but exhibited relatively poor peripheral conspicuity. Therefore it appears that if one wants to maximize the peripheral daytime conspicuity, both highly conspicuous fluorescent colors along with a fairly large target size should be selected. Such a target configuration may for example be needed to attract a driver's attention in situations where a target is located in an observer's visual periphery (peripheral angle > 20°), for example a target approaching a driver at an intersection from a left or right side street.
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Mattox, Elizabeth A. "Complications of Peripheral Venous Access Devices: Prevention, Detection, and Recovery Strategies." Critical Care Nurse 37, no. 2 (April 1, 2017): e1-e14. http://dx.doi.org/10.4037/ccn2017657.
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Most hospitalized patients have placement of a peripheral venous access device, either a short peripheral catheter or a peripherally inserted central catheter. Compared with central venous catheters that are not peripherally inserted, the other 2 types are generally perceived by health care providers as safer and less complicated to manage, and less emphasis is placed on the prevention and management of complications. Expertise of nurses in inserting, managing, and removing these devices may reduce the likelihood of complications, and increased recognition of complications associated with use of the devices is important to ensure continued improvements in the safety, quality, and efficiency of health care. Complications associated with short peripheral catheters and peripherally inserted central catheters include tourniquet retention, tubing and catheter misconnections, phlebitis, air embolism, device fragment embolization, and inadvertent discharge with a retained peripheral venous access device. Integration of prevention, detection, and recovery strategies into personal nursing practice promotes the quality and safety of health care delivery.
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Schwartz, Cecilia. "Semi-Peripheral Dynamics." Journal of World Literature 2, no. 4 (2017): 488–511. http://dx.doi.org/10.1163/24056480-00204006.
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This article aims to contribute to the understanding of the transnational dimension of Italian literature and overlooked dynamics in the literary semi-periphery. Focusing on Italian fiction in Sweden, a panoramic view of this specific semi-peripheral relation is outlined and compared to Danish and English experiences. I will then test the hypothesis that the centrality-peripherality dichotomy remains relevant to the relations of semi-peripheral literatures, but that it depends on “the modality of a specific inclusion within a system” (WReC 123). The main concern is to determine whether semi-peripheral literatures include each other as central or peripheral. More specifically, the study examines the inclusion strategies of three Swedish publishers specialized in Italian literature. Following Venuti, the inclusion modalities which are related to the publisher are visible in the selection as well as in the publisher’s epitext and peritext. These three aspects are therefore analysed with regard to peripheralization and centralization.
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Safriel, Uriel N., Sergei Volis, and Salit Kark. "CORE AND PERIPHERAL POPULATIONS AND GLOBAL CLIMATE CHANGE." Israel Journal of Plant Sciences 42, no. 4 (May 13, 1994): 331–45. http://dx.doi.org/10.1080/07929978.1994.10676584.
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Environmental conditions outside the periphery of a species' distribution prevent population persistence, hence peripheral populations live under conditions different from those of core populations. Peripheral areas are characterized by variable and unstable conditions, relative to core areas. Peripheral populations are expected to be genetically more variable, since the variable conditions induce fluctuating selection, which maintains high genetic diversity. Alternatively, due to marginal ecological conditions at the periphery, populations there are small and isolated; the within-population diversity is low, but the between-population genetic diversity is high due to genetic drift. It is also likely that peripheral populations evolve resistance to extreme conditions. Thus, peripheral populations rather than core ones may be resistant to environmental extremes and changes, such as global climate change induced by the anthropogenically emitted “greenhouse gases”. They should be treated as a biogenetic resource used for rehabilitation and restoration of damaged ecosystems. Climatic transition zones are characterized by a high incidence of species represented by peripheral populations, and therefore should be conserved now as repositories of these resources, to be used in the future for mitigating undesirable effects of global climate change. Preliminary research revealed high phenotypic variability and high genetic diversity in peripheral populations relative to core populations of wild barley and the chukar partridge, respectively.
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Diem, Heinz, Thomas Binder, and Hermann Heimpel. "Fragmentozyten im peripheren Blut Fragmented cells in peripheral blood." LaboratoriumsMedizin 29, no. 5 (January 1, 2005): 331–32. http://dx.doi.org/10.1515/jlm.2005.045.
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Shingleton, Bradford J., Iftikhar M. Chaudhry, and Mark W. OʼDonoghue. "Phacotrabeculectomy: Peripheral iridectomy or no peripheral iridectomy?" Journal of Cataract & Refractive Surgery 28, no. 6 (June 2002): 998–1002. http://dx.doi.org/10.1016/s0886-3350(01)01180-4.
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McGowan, Donna. "Peripheral cannulation versus peripheral inserted central catheter." British Journal of Nursing 22, Sup5 (April 25, 2013): S22. http://dx.doi.org/10.12968/bjon.2013.22.sup5.s22.
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Ghali, Abdullah. "Paclitaxel Mortality in Peripheral Artery Disease." Journal of Thoracic Disease and Cardiothoracic Surgery 2, no. 1 (April 28, 2021): 01–03. http://dx.doi.org/10.31579/2693-2156/019.
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Peripheral artery disease is a matter of global concern that affects 200 million people and is associated with decreased arterial perfusion in the extremities. The most plausible pathomechanism involves the formation of atheromas which subsequently cause occlusive atherosclerosis that impinge blood supply. Atheroma formation involves endothelial dysfunction with an accumulation of LDL (Low-density lipoprotein) that subsequently become oxidized and consumed by macrophages to form foam cells. The foam cells will release factors such as MMPs (Matrix metalloproteinases) and PDGF (platelet derived growth factor) that induce the proliferation and migration of smooth muscle cells, forming atheroma. Furthermore, endothelial cell damage can cause a loss of protective mechanisms, such as a reduction in the release of protective vasodilatory prostaglandins and Nitric Oxide. Atherosclerosis formation also decreases oxygen diffusion to the arterial media, resulting in atrophy in the vessel wall and ischemia. Additionally, chronic transmural inflammation cyclically releases increased MMPs and elastases that expand the arterial wall while degrading the protective collagen.
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George, Saranya. "Giant Peripheral Ossifying Fibroma of Maxilla." Indian Journal of Dental Education 10, no. 2 (2017): 74–77. http://dx.doi.org/10.21088/ijde.0974.6099.10217.15.
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William, Ryan. "Segmental Defects in Peripheral Nerves Xenotransplantation." Dermatology and Dermatitis 2, no. 5 (July 9, 2018): 01–02. http://dx.doi.org/10.31579/2578-8949/036.
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Segmental defects in peripheral nerves that cannot be sutured directly require the use of nerve grafts. The ideal option for repair is nerve auto grafting, but there are some obvious disadvantages related to its use, such as lack of availability and donor site morbidity. The next step to consider for reconstruction is the use of nerve allografts, but they are also limited for clinical use, and they present with the added problem of graft rejection. Considering these limitations to the use of nerve autografts and allografts, clinical surgery research has turned to nerve xenotransplantation, which offers a potentially unlimited source of donor nerves.
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Gopal, Shalini, Rashmi Naik, Ahmed Mujib B.R, and Arun Kumar N. "GENDER DETERMINATION USING PERIPHERAL BLOOD SMEAR." International Journal of Anatomy and Research 6, no. 2.1 (April 5, 2018): 5079–82. http://dx.doi.org/10.16965/ijar.2018.115.
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Pejnović, Dane. "Lika: Demographic Development under Peripheral Conditions." Hrvatski geografski glasnik/Croatian Geographical Bulletin 66, no. 02 (December 2004): 23–46. http://dx.doi.org/10.21861/hgg.2004.66.02.02.
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Rahman, Mohammad Khalilur. "Common Mechanisms of Peripheral Vascular Injuries." Annals of International Medical and Dental Research 9, no. 2 (April 2023): 218–23. http://dx.doi.org/10.53339/aimdr.2023.9.31.
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Background: The peripheral arteries and veins of the extremities are among the most commonly injured vessels in both civilian and warfare trauma. Traumatic vascular injury is caused by explosions and projectiles which may affect the arteries and veins of the limbs, and is common in wartime, triggering bleeding and ischemia. This study aimed to analyze the common mechanisms of peripheral vascular injuries. Material Methods: This was a retrospective study and was carried out among 60 cases who attended the vascular surgery department at the National Institute of Cardiovascular Disease (NICVD), with vascular injury from January 20010 to January 2012. All data were analyzed by SPSS 10 version. Results: In this study, most of the patients (25, 41.6%) were in the 21-30 years age group, followed by 20 patients (33.33%0 were in the 31-45 years age group and the rest 15 (25.0%) patients belonged to 15-20 years age group. Regarding sex distribution, male (48, 80.0%) was more preponderance than female (12, 20.0%). Concerning occupation, most of the subjects (50.0%) were students, followed by businessmen (33.0%) and service holders (17.0%). Regarding the mechanism of injury, most of the patients (25, 41.66%) had bullet injuries, followed by 20 (33.33%) had shrapnel injuries, and the rest 15 (25.0%) patients had blunt injuries. Concerning limb involvement, the upper limb was injured in most of the cases (37, 61.66%), followed by the lower limb (23, 38.33%). Conclusion: In this study, bullet injuries were the commonest mechanism of peripheral vessel injury followed by, shrapnel injuries and blunt injuries.
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Vineela, Tummidi, Raju S Iyer, and Lella Nageswara Rao. "Peripheral Artery Pseudoaneurysms Following Cathlab Interventions." International Journal of Science and Research (IJSR) 12, no. 11 (November 5, 2023): 188–91. http://dx.doi.org/10.21275/sr231007112823.
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Badan, Linda, and Claudia Crocco. "Italian wh-questions and the low periphery." Linguistics 59, no. 3 (May 1, 2021): 757–84. http://dx.doi.org/10.1515/ling-2021-0059.
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Abstract This article deals with Italian questions with a post-verbal wh-element, which are generally defined as in situ. We show that post-verbal wh-questions can be interpreted as information-seeking questions, and provide syntactic arguments supporting the hypothesis that the post-verbal wh-element is only apparently in situ. We claim that, in certain contexts, the post-verbal wh-element undergoes a syntactic movement targeting a low-peripheral focus position dedicated to the expression of informational focus. We integrate our analysis with the examination of a number of cases of low-peripheral wh-elements from the CLIPS and LIP corpora of spoken Italian. As for prosody, the available data show that a sentence-final wh-element carries the nuclear accent of the utterance. Moreover, low-peripheral wh-questions seem pragmatically more restricted compared to their counterparts with a fronted wh-. Although further investigation may reveal additional contexts for the questions at stake, low-peripheral wh-questions need to be linked to the preceding discourse context and can be used to add emphasis to the missing piece of information represented by the wh-element. Our low-peripheral analysis complements the current left-peripheral analysis of Italian wh-questions: wh-elements in left and low periphery display different interpretive and prosodic properties, indicating that they are involved in different phenomena. The results of this study also support the view that the low periphery is more subject to pragmatic restrictions compared to the left periphery.
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Bian, Qian, Nimish Khanna, Jurgis Alvikas, and Andrew S. Belmont. "β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications." Journal of Cell Biology 203, no. 5 (December 2, 2013): 767–83. http://dx.doi.org/10.1083/jcb.201305027.
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Increasing evidence points to nuclear compartmentalization as a contributing mechanism for gene regulation, yet mechanisms for compartmentalization remain unclear. In this paper, we use autonomous targeting of bacterial artificial chromosome (BAC) transgenes to reveal cis requirements for peripheral targeting. Three peripheral targeting regions (PTRs) within an HBB BAC bias a competition between pericentric versus peripheral heterochromatin targeting toward the nuclear periphery, which correlates with increased H3K9me3 across the β-globin gene cluster and locus control region. Targeting to both heterochromatin compartments is dependent on Suv39H-mediated H3K9me3 methylation. In different chromosomal contexts, PTRs confer no targeting, targeting to pericentric heterochromatin, or targeting to the periphery. A combination of fluorescent in situ hybridization, BAC transgenesis, and knockdown experiments reveals that peripheral tethering of the endogenous HBB locus depends both on Suv39H-mediated H3K9me3 methylation over hundreds of kilobases surrounding HBB and on G9a-mediated H3K9me2 methylation over flanking sequences in an adjacent lamin-associated domain. Our results demonstrate that multiple cis-elements regulate the overall balance of specific epigenetic marks and peripheral gene targeting.
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van Diepen, Paul M. J., and Martien Wampers. "Scene Exploration with Fourier-Filtered Peripheral Information." Perception 27, no. 10 (October 1998): 1141–51. http://dx.doi.org/10.1068/p271141.
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In a previous moving-window study it was found that scene exploration benefits more from peripheral information of high spatial frequency than of low spatial frequency. In the present study, degraded versions of realistic scenes were presented peripherally during the initial 150 ms of fixations, while the undegraded scene was presented foveally. The undegraded version of the scene was visible both foveally and peripherally during the later part of fixations. During the initial 150 ms, the peripheral part of scenes was low-pass, bandpass, or high-pass filtered, blanked, or decreased in luminance. In a no-change condition, the undegraded scene was presented throughout the whole fixation. Participants freely explored the scenes in the context of an object-decision task. It was found that degrading peripheral information during the initial part of fixations had minimal effect on scene exploration. No reliable differences were found among the three filter types. The results indicate that, in the context of an object-search task, peripheral information is of minor importance during the initial part of fixations.
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Prokop, Stefan, Kelly R. Miller, Natalia Drost, Susann Handrick, Vidhu Mathur, Jian Luo, Anja Wegner, Tony Wyss-Coray, and Frank L. Heppner. "Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice." Journal of Experimental Medicine 212, no. 11 (October 12, 2015): 1811–18. http://dx.doi.org/10.1084/jem.20150479.
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Although central nervous system–resident microglia are believed to be ineffective at phagocytosing and clearing amyloid-β (Aβ), a major pathological hallmark of Alzheimer’s disease (AD), it has been suggested that peripheral myeloid cells constitute a heterogeneous cell population with greater Aβ-clearing capabilities. Here, we demonstrate that the conditional ablation of resident microglia in CD11b-HSVTK (TK) mice is followed by a rapid repopulation of the brain by peripherally derived myeloid cells. We used this system to directly assess the ability of peripheral macrophages to reduce Aβ plaque pathology and therefore depleted and replaced the pool of resident microglia with peripherally derived myeloid cells in Aβ-carrying APPPS1 mice crossed to TK mice (APPPS1;TK). Despite a nearly complete exchange of resident microglia with peripheral myeloid cells, there was no significant change in Aβ burden or APP processing in APPPS1;TK mice. Importantly, however, newly recruited peripheral myeloid cells failed to cluster around Aβ deposits. Even additional anti-Aβ antibody treatment aimed at engaging myeloid cells with amyloid plaques neither directed peripherally derived myeloid cells to amyloid plaques nor altered Aβ burden. These data demonstrate that mere recruitment of peripheral myeloid cells to the brain is insufficient in substantially clearing Aβ burden and suggest that specific additional triggers appear to be required to exploit the full potential of myeloid cell–based therapies for AD.
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Hess, Robert F., and Jim McCarthy. "Topological disorder in peripheral vision." Visual Neuroscience 11, no. 5 (September 1994): 1033–36. http://dx.doi.org/10.1017/s0952523800003977.
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AbstractOne of the most striking properties of the mammalian visual system is that it is only the central part of the visual field, the fovea, where vision is most acute. The superiority of the fovea is particularly evident in tasks requiring accurate spatial localization. It is currently thought that peripheral spatial uncertainty is a simple consequence of the decreased sampling grain of the peripheral field. We show that the topological fidelity of the afferent projection declines with eccentricity away from the fovea and that it is this rather than the sampling grain that underlies the poorer performance of the periphery in tasks involving spatial localization. The combination of normal sampling and a disordered topology results in the periphery having good sensitivity for detection but poor sensitivity for object recognition.
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Powell, Sara M., Andrew C. Faust, Stephy George, Richard Townsend, Darla Eubank, and Richard Kim. "Effect of Peripherally Infused Norepinephrine on Reducing Central Venous Catheter Utilization." Journal of Infusion Nursing 46, no. 4 (July 2023): 210–16. http://dx.doi.org/10.1097/nan.0000000000000508.
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The purpose of this retrospective study was to evaluate the impact of peripherally administered norepinephrine on avoiding central venous catheter insertion while maintaining safety of the infusion. An institutional guideline allows peripheral infusion of norepinephrine via dedicated, 16- to 20-gauge, mid-to-upper arm intravenous (IV) catheters for up to 24 hours. The primary outcome was the need for central venous access in patients initially started on peripherally infused norepinephrine. A total of 124 patients were evaluated (98 initially on peripherally infused norepinephrine vs 26 with central catheter only administration). Thirty-six (37%) of the 98 patients who were started on peripheral norepinephrine avoided the need for central catheter placement, which was associated with $8,900 in direct supply cost avoidance. Eighty (82%) of the 98 patients who started peripherally infused norepinephrine required the vasopressor for ≤12 hours. No extravasation or local complications were observed in any of the 124 patients, regardless of site of infusion. Administration of norepinephrine via a dedicated peripheral IV site appears safe and may lead to a reduction in the need for subsequent central venous access. To achieve timely resuscitation goals, as well as to minimize complications associated with central access, initial peripheral administration should be considered for all patients.
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Rothpletz, Ann M., Daniel H. Ashmead, and Anne Marie Tharpe. "Responses to Targets in the Visual Periphery in Deaf and Normal-Hearing Adults." Journal of Speech, Language, and Hearing Research 46, no. 6 (December 2003): 1378–86. http://dx.doi.org/10.1044/1092-4388(2003/107).
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The purpose of this study was to compare the response times of deaf and normal-hearing individuals to the onset of target events in the visual periphery in distracting and nondistracting conditions. Visual reaction times to peripheral targets placed at 3 eccentricities to the left and right of a center fixation point were measured in prelingually deafened adults and normal-hearing adults. Deaf participants responded more slowly than normal-hearing participants to targets in the near periphery in the nondistracting condition and to targets in the near and distant periphery when distracting stimuli were present. One interpretation of these findings is that deaf individuals may be more deliberate than normal-hearing individuals in responding to near peripheral events and to peripheral events that occur in the presence of distracting stimuli.
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Khene, Samson, and Tebello Nyokong. "Single walled carbon nanotubes functionalized with nickel phthalocyanines: effects of point of substitution and nature of functionalization on the electro-oxidation of 4-chlorophenol." Journal of Porphyrins and Phthalocyanines 16, no. 01 (January 2012): 130–39. http://dx.doi.org/10.1142/s1088424611004439.
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In this work we report on electrochemical behavior of nickel phthalocyanine derivatives tetrasubstituted peripherally and non-peripherally with hydroxy and used to modify single walled carbon nanotubes. Nickel phthalocyanine complex octasubstituted at the peripheral positions with hydroxy groups was also used to modify single walled carbon nanotubes. Nickel phthalocyanine complex tetrasubstituted with amino groups at peripheral position was covalently and non-covalently linked to single walled carbon nanotubes. All the conjugates of nickel phthalocyanine derivatives with single walled carbon nanotubes were used for the electro oxidation of 4-chlorophenol. The nickel phthalocyanine octabsubstituted with hydroxy groups at the non-peripheral positions gave the best current response and the best resistance against electrode fouling for the oxidation of 4-chlorophenol.
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Pacilli, Maurizio, Catherine J. Bradshaw, and Simon A. Clarke. "Use of 8-cm 22G-long peripheral cannulas in pediatric patients." Journal of Vascular Access 19, no. 5 (March 12, 2018): 496–500. http://dx.doi.org/10.1177/1129729818761278.
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Introduction: Medium-term intravenous access in children is normally achieved by means of repeated multiple peripheral intravenous cannula insertions or peripherally inserted central catheters. Long peripheral cannulas might offer an alternative to these devices in children. Our aim was to clarify whether long peripheral cannulas provide reliable medium-term intravenous access avoiding the need for multiple peripheral intravenous cannulations or peripherally inserted central catheter insertion in children undergoing surgery. Methods: Following ethical approval, we prospectively collected data in children requiring medium-term intravenous access. The 22G-8-cm-long peripheral cannulas were inserted with a Seldinger technique in a peripheral vein. Position was checked by flushing and aspirating the catheter. Results are reported as mean ± standard deviation. Results: A total of 18 children were included. Indications for medium-term intravenous therapy included perforated appendicitis (n = 14), infected central venous port (n = 2), fungal infection (n = 1) and septic arthritis (n = 1). In all, 15 (83%) patients underwent the procedure under general anaesthetic. The procedure failed in an 8-year-old patient. Insertion time was 8 ± 3.7 min. Age at insertion was 6.3 ± 4.9 years. Duration of intravenous therapy was 6.4 ± 5.1 days. About 13 (76%) patients completed the treatment with no complications. Three (17%) lines occluded by day 3 needed removal; one (7%) line needed removal on day 3 because of redness/pain noted around the insertion site. Conclusion: Long peripheral cannulas represent a valid option for medium-term intravenous access in children undergoing surgery. Majority of patients will be successfully treated with one long peripheral cannula for the duration of their treatment without the need for further cannulation.
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Huang, Chun Ming, Kai Chao Yang, Yu Tsang Chang, Chien Ming Wu, and Shian Wen Chen. "A Tiny Development Platform with Virtualized Peripherals for Education of Embedded Software Design." Advanced Materials Research 748 (August 2013): 936–40. http://dx.doi.org/10.4028/www.scientific.net/amr.748.936.
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In the embedded software education, it is usually a burden to give every student a development board in the class due to limited budget. Besides, peripheral devices such as LCD panels also increase the cost. A cheap and flexible way is to use virtual embedded systems in the class. However, virtual systems cannot completely reflect the developing environment on real platforms. In this article, we propose the idea that combines the virtual and real embedded platforms. The proposed platform preserves the core of the hardware board, so that developers can design embedded software applications in the real developing environment. In addition, we eliminate the peripheral wires and connectors on hardware board and use virtual peripherals and peripherals on PC instead, such that designers can easily control and change peripherals. The proposed idea can significantly reduce cost and increase flexibility when teaching embedded software design. Moreover, the size of development board can be reduced as well. Without the restriction of peripheral connectors and devices, development boards become portable and more easy to use.
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Berzins, S. P., R. L. Boyd, and J. F. A. P. Miller. "The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool." Journal of Experimental Medicine 187, no. 11 (June 1, 1998): 1839–48. http://dx.doi.org/10.1084/jem.187.11.1839.
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The thymus is essential for the initial seeding of T cells to the periphery, but its role in maintaining the adult T cell pool remains poorly defined. We investigated whether changes to the rate of T cell export could form part of the mechanism(s) controlling the homeostatic regulation of the size and composition of the peripheral T cell pool. Using neonatal thymi grafted under the kidney capsule, we found that irrespective of whether the pool was oversupplied (by thymic grafts) or undersupplied (due to neonatal thymectomy), the thymic export rate was constant from both the host and graft thymus, and the periphery remained constant in size. Recent thymic emigrants (RTE) were also tracked to determine the extent of their acceptance into the T cell pool of a normal mouse. As a population, RTE are phenotypically mature, but were distinct from resident T cells in the periphery, being released in a CD4/CD8 ratio approximately twice that of established peripheral T cells. This export ratio is similar to that of T cells in the mature thymic compartment, but soon after entry into the periphery, the ratio falls, indicating separate thymic and peripheral regulation of the CD4/CD8 ratio. RTE may also be preferentially incorporated into the periphery, causing displacement of resident T cells, thus maintaining the size of the peripheral pool. Although not vital for the maintenance of a functional T cell pool, the acceptance of RTE in a “full” peripheral pool would ensure that the T cell receptor repertoire is kept diverse and that the T cell population encompasses a broad range of naive as well as memory T cells.
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Capelli, Valentina, Carmen Grijota-Martínez, Nathalia R. V. Dragano, Eval Rial-Pensado, Johan Fernø, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, and Miguel López. "Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase." Nutrients 13, no. 12 (November 24, 2021): 4204. http://dx.doi.org/10.3390/nu13124204.
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Besides their direct effects on peripheral metabolic tissues, thyroid hormones (TH) act on the hypothalamus to modulate energy homeostasis. However, since most of the hypothalamic actions of TH have been addressed in studies with direct central administration, the estimation of the relative contribution of the central vs. peripheral effects in physiologic conditions of peripheral release (or administration) of TH remains unclear. In this study we used two different models of peripherally induced hyperthyroidism (i.e., T4 and T3 oral administration) to assess and compare the serum and hypothalamic TH status and relate them to the metabolic effects of the treatment. Peripheral TH treatment affected feeding behavior, overall growth, core body temperature, body composition, brown adipose tissue (BAT) morphology and uncoupling protein 1 (UCP1) levels and metabolic activity, white adipose tissue (WAT) browning and liver metabolism. This resulted in an increased overall uncoupling capacity and a shift of the lipid metabolism from WAT accumulation to BAT fueling. Both peripheral treatment protocols induced significant changes in TH concentrations within the hypothalamus, with T3 eliciting a downregulation of hypothalamic AMP-activated protein kinase (AMPK), supporting the existence of a central action of peripheral TH. Altogether, these data suggest that peripherally administered TH modulate energy balance by various mechanisms; they also provide a unifying vision of the centrally mediated and the direct local metabolic effect of TH in the context of hyperthyroidism.
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Yang, Bo, Xu Li, Weizheng Cheng, Zhiyong Pei, Tao Huang, Hui Hou, and Xuelin Huang. "Effects of core-periphery structure on explosive synchronization." International Journal of Modern Physics B 34, no. 30 (October 21, 2020): 2050290. http://dx.doi.org/10.1142/s0217979220502902.
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We investigate the explosive synchronization in networks with core-periphery structure. The effects of different patterns of core-periphery networks on explosive synchronization are studied by altering network structural parameters. With the variation of two core-periphery structural parameters, the relative connection strength between core and peripheral nodes, and the relative connection strength among peripheral nodes, we find distinct roles played by structural parameters in the path toward explosive synchronization. Our results show that the order parameter of periphery is closer to that of the core in the synchronization phase with the increment of connections between core and peripheral nodes. In addition, we find that sparser the connections among peripheral nodes are, the easier the whole dynamic network is to reach explosive synchronization. We also discover that if the number of connections between core and periphery scales vary sublinearly with the network size, there exists a novel two-jump behavior of the order parameter of the whole network. Moreover, as the level of the sublinearity increases, the order parameter starts to oscillate in a decaying manner, rather than being increasing monotonically and slowly as in the case of normal explosive synchronization when the coupling strength exceeds a critical threshold. Hence in this regime, it becomes increasingly difficult for the network to maintain stable explosive synchronization even though the underlying network topology is connected.
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Liu, Yulin, Sufang Huang, Haining Wang, Yueliang Hou, Xianzhuan He, Xinwei Zhu, Ting Li, and Xiaolu Liu. "System Verification Scheme Based on an MCU." Journal of Physics: Conference Series 2166, no. 1 (January 1, 2022): 012004. http://dx.doi.org/10.1088/1742-6596/2166/1/012004.
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Abstract In order to systematically verify the common functions of each peripheral of the chip, find out the problems in the process of chip design in time, and avoid mutual interference between the peripherals of the chip, it is very necessary to systematically verify the chip. The MCU involved in this verification scheme has three cores and several peripherals such as UART, SPI, USB, GMAC and DCMI. In this paper, the common functions of the peripherals of the MCU are verified systematically, and the verification methods of each peripheral are described in detail. The software of this scheme is layered and modular, and the verification system realized according to this scheme can be conveniently transplanted to different chips.
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Hiraga, Shin-ichiro, Sotirios Botsios, David Donze, and Anne D. Donaldson. "TFIIIC localizes budding yeast ETC sites to the nuclear periphery." Molecular Biology of the Cell 23, no. 14 (July 15, 2012): 2741–54. http://dx.doi.org/10.1091/mbc.e11-04-0365.
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Chromatin function requires specific three-dimensional architectures of chromosomes. We investigated whether Saccharomyces cerevisiae extra TFIIIC (ETC) sites, which bind the TFIIIC transcription factor but do not recruit RNA polymerase III, show specific intranuclear positioning. We show that six of the eight known S. cerevisiae ETC sites localize predominantly at the nuclear periphery, and that ETC sites retain their tethering function when moved to a new chromosomal location. Several lines of evidence indicate that TFIIIC is central to the ETC peripheral localization mechanism. Mutating or deleting the TFIIIC-binding consensus ablated ETC -site peripheral positioning, and inducing degradation of the TFIIIC subunit Tfc3 led to rapid release of an ETC site from the nuclear periphery. We find, moreover, that anchoring one TFIIIC subunit at an ectopic chromosomal site causes recruitment of others and drives peripheral tethering. Localization of ETC sites at the nuclear periphery also requires Mps3, a Sad1-UNC-84–domain protein that spans the inner nuclear membrane. Surprisingly, we find that the chromatin barrier and insulator functions of an ETC site do not depend on correct peripheral localization. In summary, TFIIIC and Mps3 together direct the intranuclear positioning of a new class of S. cerevisiae genomic loci positioned at the nuclear periphery.
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Arsenović-Ranin, Nevena, Duško Kosec, Mirjana Nacka-Aleksić, Ivan Pilipović, Zorica Stojić-Vukanić, Jasmina Djikić, Biljana Bufan, and Gordana Leposavić. "Ovarian hormone level alterations during rat post-reproductive life-span influence CD8 + T-cell homeostasis." Experimental Biology and Medicine 240, no. 10 (February 24, 2015): 1319–32. http://dx.doi.org/10.1177/1535370215570817.
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The study examined the putative role of ovarian hormones in shaping of rat peripheral T-cell compartment during post-reproductive period. In 20-month-old rats ovariectomized (Ox) at the very end of reproductive period, thymic output, cellularity and composition of major TCRαβ + peripheral blood lymphocyte and splenocyte subsets were analyzed. Ovariectomy led to the enlargement of CD8 + peripheral blood lymphocyte and splenocyte subpopulations. This reflected: (i) a more efficient thymic generation of CD8 + cells as indicated by increased number of CD4+CD8 + double positive and the most mature CD4-CD8+TCRαβhigh thymocytes and CD8 + recent thymic emigrants (RTEs) in peripheral blood, but not in the spleen of Ox rats, and (ii) the expansion of CD8 + memory/activated peripheral blood lymphocytes and splenocytes. The latter was consistent with a greater frequency of proliferating cells among freshly isolated memory/activated CD8 + peripheral blood lymphocytes and splenocytes and increased proliferative response of CD8 + splenocytes to stimulation with plate-bound anti-CD3 antibody. The former could be related to the rise in splenic IL-7 and IL-15 mRNA expression. Although ovariectomy affected the overall number of CD4 + T cells in none of the examined compartments, it increased CD4+FoxP3 + peripheral blood lymphocyte and splenocyte counts by enhancing their generation in periphery. Collectively, the results suggest that ovariectomy-induced long-lasting disturbances in ovarian hormone levels (mirrored in diminished progesterone serum level in 20-month-old rats) affects both thymic CD8 + cell generation and peripheral homeostasis and leads to the expansion of CD4+FoxP3 + cells in the periphery, thereby enhancing autoreactive cell control on account of immune system efficacy to combat infections and tumors.
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Garvey Brickner, Donna, and Jason H. Brickner. "Cdk Phosphorylation of a Nucleoporin Controls Localization of Active Genes through the Cell Cycle." Molecular Biology of the Cell 21, no. 19 (October 2010): 3421–32. http://dx.doi.org/10.1091/mbc.e10-01-0065.
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Many inducible genes in yeast are targeted to the nuclear pore complex when active. We find that the peripheral localization of the INO1 and GAL1 genes is regulated through the cell cycle. Active INO1 and GAL1 localized at the nuclear periphery during G1, became nucleoplasmic during S-phase, and then returned to the nuclear periphery during G2/M. Loss of peripheral targeting followed the initiation of DNA replication and was lost in cells lacking a cyclin-dependent kinase (Cdk) inhibitor. Furthermore, the Cdk1 kinase and two Cdk phosphorylation sites in the nucleoporin Nup1 were required for peripheral targeting of INO1 and GAL1. Introduction of aspartic acid residues in place of either of these two sites in Nup1 bypassed the requirement for Cdk1 and resulted in targeting of INO1 and GAL1 to the nuclear periphery during S-phase. Thus, phosphorylation of a nuclear pore component by cyclin dependent kinase controls the localization of active genes to the nuclear periphery through the cell cycle.
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Upton, Lee. "Peripheral Matters." Antioch Review 49, no. 4 (1991): 561. http://dx.doi.org/10.2307/4612459.
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