Relevant bibliographies by topics / Peripheral arteries disease

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Peripheral arteries disease'

Author: Grafiati
Published: 29 March 2025

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Journal articles on the topic "Peripheral arteries disease"

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Yu, Shikai, and Carmel M. McEniery. "Central Versus Peripheral Artery Stiffening and Cardiovascular Risk." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 5 (May 2020): 1028–33. http://dx.doi.org/10.1161/atvbaha.120.313128.

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The large elastic arteries fulfill an important role in buffering the cyclical changes in blood pressure, which result from intermittent ventricular ejection. With aging and accrual of cardiovascular risk factors, the elastic arteries stiffen, and this process holds a number of deleterious consequences for the cardiovascular system and major organs. Indeed, arterial stiffness is now recognized as an important, independent determinant of cardiovascular disease risk. Additional, important information concerning the mechanisms underlying arterial stiffening has come from longitudinal studies of arterial stiffness. More recently, attention has focused on the role of peripheral, muscular arteries in cardiovascular disease risk prediction and, in particular, the clinical consequences of reversal of the normal gradient of arterial stiffness between central and peripheral arteries, with aging and disease.
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Virtanen, Juha, Markus Varpela, Fausto Biancari, Juho Jalkanen, and Harri Hakovirta. "Association between anatomical distribution of symptomatic peripheral artery disease and cerebrovascular disease." Vascular 28, no. 3 (January 24, 2020): 295–300. http://dx.doi.org/10.1177/1708538119893825.

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Aim Peripheral arterial disease is frequently associated with significant atherosclerosis of other vascular beds. The aim of the present study was to investigate a possible association between peripheral arterial disease segment-specific disease burden and cerebrovascular disease. Methods Two-hundred and twenty-six patients with clinically symptomatic peripheral arterial disease from the prospective PureASO registry were followed up after revascularization. The breadth of peripheral arterial disease was quantified at the time patients entered the study. The segment-specific peripheral arterial disease burden was correlated to cerebrovascular disease and imaging findings during a five-year follow-up. Results At five years, cerebrovascular disease-free survival after lower limb revascularization was 31%. Patients with peripheral arterial disease involving the crural arteries had significantly more ischemic degenerative changes at brain imaging ( p = 0.031), whereas patients with aorto-iliac and femoropopliteal segment peripheral arterial disease had more significant (>50% uni- or bilaterally) internal carotid artery stenosis compared to patients with crural peripheral arterial disease ( p = 0.006). According to Cox regression analyses, crural arteries burden was associated with a significantly increased risk of mortality (adjusted HR 2.07, CI 95% 1.12–3.28, p = 0.021) and cerebrovascular events (adjusted HR 1.97, CI 95% 1.19–3.26, p = 0.008). Conclusions Present results suggest that atherosclerosis burden at different lower limb artery segments is associated with defined cerebrovascular disease. This further suggests that risk factors and pathophysiological mechanisms are congruent across particular vascular beds.
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Bez, Leonardo Ghizoni, and Túlio Pinho Navarro. "Study of carotid disease in patients with peripheral artery disease." Revista do Colégio Brasileiro de Cirurgiões 41, no. 5 (October 2014): 311–18. http://dx.doi.org/10.1590/0100-69912014005003.

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Objective: To study the stenosis of the carotid arteries in patients with symptomatic peripheral arterial disease.Methods: we assessed 100 consecutive patients with symptomatic peripheral arterial disease in stages of intermittent claudication, rest pain or ulceration. Carotid stenosis was studied by echo-color-doppler, and considered significant when greater than or equal to 50%. We used univariate analysis to select potential predictors of carotid stenosis, later taken to multivariate analysis.Results: The prevalence of carotid stenosis was 84%, being significant in 40% and severe in 17%. The age range was 43-89 years (mean 69.78). Regarding gender, 61% were male and 39% female. Half of the patients had claudication and half had critical ischemia. Regarding risk factors, 86% of patients had hypertension, 66% exposure to smoke, 47% diabetes, 65% dyslipidemia, 24% coronary artery disease, 16% renal failure and 60% had family history of cardiovascular disease. In seven patients, there was a history of ischemic cerebrovascular symptoms in the carotid territory. The presence of cerebrovascular symptoms was statistically significant in influencing the degree of stenosis in the carotid arteries (p = 0.02 at overall assessment and p = 0.05 in the subgroups of significant and non-significant stenoses).Conclusion: the study of the carotid arteries by duplex scan examination is of paramount importance in the evaluation of patients with symptomatic peripheral arterial disease, and should be systematically conducted in the study of such patients.
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Opincariu, Diana, András Mester, Imre Benedek, and István Benedek. "Stem Cell Therapies in Peripheral Vascular Diseases — Current Status." Journal of Interdisciplinary Medicine 2, s4 (December 1, 2017): 12–19. http://dx.doi.org/10.1515/jim-2017-0093.

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AbstractPeripheral artery diseases include all arterial diseases with the exception of coronary and aortic involvement, more specifically diseases of the extracranial carotids, upper limb arteries, mesenteric and renal vessels, and last but not least, lower limb arteries. Mononuclear stem cells, harvested from various sites (bone marrow, peripheral blood, mesenchymal cells, adipose-derived stem cells) have been studied as a treatment option for alleviating symptoms in peripheral artery disease, as potential stimulators for therapeutic angiogenesis, thus improving vascularization of the ischemic tissue. The aim of this manuscript was to review current medical literature on a novel treatment method — cell therapy, in patients with various peripheral vascular diseases, including carotid, renal, mesenteric artery disease, thromboangiitis obliterans, as well as upper and lower limb artery disease.
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Gajnitdinova, V. V., A. B. Bakirov, E. Kh Akhmetzyanova, N. F. Berdikaeva, and V. B. Zakirova. "Arterial stiffness of peripheral vasculature in patients with chronic obstructive pulmonary disease and its association with arterial hypertension." Kazan medical journal 94, no. 6 (December 15, 2013): 808–12. http://dx.doi.org/10.17816/kmj1795.

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Aim. To study the structural and functional state of vascular wall, arterial stiffness of large peripheral arteries (common carotid arteries, renal arteries) in patients with severe chronic obstructive pulmonary disease and its association with arterial hypertension. Methods. The study included 67 patients of working age, mainly males, having chronic obstructive pulmonary disease. Among them, 52 patients had severe chronic obstructive pulmonary disease (defined by GOLD III, 2011), 15 had concomitant arterial hypertension of I and II stage. Structural and functional status of common carotid arteries, renal arteries was assessed by measurement of intima-media thickness, arterial stiffness indexes were calculated. Arterial elasticity indices: arterial compliance, elastic index, Young’s elastic modulus were calculated based on the results of ultrasonography of main arterial wall parameters (diameter, arterial wall thickness) and blood pressure measurement. Results. A decrease in common carotid arteries and renal arteries wall elasticity was revealed in patients with chronic obstructive pulmonary disease. Increase of stiffness index in patients with severe chronic obstructive pulmonary disease associated with arterial hypertension, marking the decreased arterial wall elasticity, was registered both in common carotid arteries and renal arteries. Conclusion. In common carotid arteries vascular wall thickness contribute the most in vascular wall stiffness increase, compared to altered hemodynamics in renal arteries. Development of arterial hypertension in these patients is a predicting factor for further large vessel remodeling associated with hypoxia.
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Heinrich, Jürgen, Helmut Schulte, Rainer Schönfeld, Ekkehart Köhler, and Gerd Assmann. "Association of Variables of Coagulation, Fibrinolysis and Acute-phase with Atherosclerosis in Coronary and Peripheral Arteries and those Arteries Supplying the Brain." Thrombosis and Haemostasis 73, no. 03 (1995): 374–79. http://dx.doi.org/10.1055/s-0038-1653783.

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SummaryWe investigated the vessel status of coronary and peripheral arteries and those arteries supplying the brain in 929 consecutive male patients admitted to a coronary rehabilitation unit. The severity of coronary atherosclerosis was scored using coronary angiography. Changes in extracranial brain vessels and manifest cerebrovascular disease (CVD) were determined by B-mode ultrasound and Doppler examination. Peripheral arterial disease (PAD) was diagnosed using base-line and stress oscillography. We assessed variables of coagulation, fibrinolysis, and the acute phase response.There was a significant increase in plasma fibrinogen, plasminogen, d-dimer and C-reactive protein (CRP) with increasing severity of coronary heart disease. Compared to men with unaffected arteries, men with 3 diseased coronary arteries had 58% greater d-dimer concentrations. Patients with CVD and PAD, respectively, also had significantly higher fibrinogen, d-dimer and CRP concentrations. We did not find an association between plasminogen activator inhibitor activity and the severity of coronary atherosclerosis.In conclusion, plasma fibrinogen, d-dimer and CRP concentrations were significantly related to atherosclerosis in the coronary, peripheral and extracranial brain arteries.
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Denisenko, M. N., V. V. Genkel, and I. I. Shaposhnik. "Endothelial dysfunction in patients with hypertension and peripheral artery disease." Kazan medical journal 97, no. 5 (October 15, 2016): 691–95. http://dx.doi.org/10.17750/kmj2016-691.

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Aim. To assess endothelial function in patients with hypertension and peripheral artery disease.Methods. The study included 100 patients with an established diagnosis of essential hypertension. Ultrasonic duplex scanning of brachiocephalic arteries and lower limb arteries was performed. The functional state of the endothelium was evaluated using postocclusive reactive hyperemia test by D.S. Celermajer.Results. Atherosclerotic plaques in the carotid arteries were found in 71% of patients, in the lower limb arteries - in 60%. The combined affection of both vascular beds was diagnosed in 51% of patients. Endothelial dysfunction was found in 64% of patients. In patients with carotid arterial system atherosclerosis, brachial artery dilation response was 6.1%, while in those with intact carotid arteries - 4.7% (p=0.041). The value of the brachial artery dilation response in patients with atherosclerotic lesions of lower extremities arteries was 5.9%. In the subgroup of patients with intact lower limbs arteries, the increase in brachial artery diameter was 9.60% an average (p=0.04). Among 51 people with affection of both vascular systems the brachial artery diameter increase was 5.4%, while in comparison, in the subgroup consisting of 49 patients without combined carotid and lower limb arteries lesions, - 9.9% (p=0.003). According to the results of the correlation analysis, the relation between endothelial dysfunction and the maximum percentage of stenosis of the carotid arteries and lower limb arteries at the level of tibial segment was revealed.Conclusion. In patients with hypertension and peripheral artery disease, decrease in dilation response in endothelium-dependent vasodilation test was registered regardless of the localization of atherosclerotic lesions; endothelial dysfunction in essential hypertension was associated with the highest percentage of stenosis of the carotid arteries and lower limb arteries at the level of tibial segment.
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Catalano, Maria, Giovanni Scandale, Tao Jun, Marzio Minola, Martino Recchia, and Massimo Annoni. "Radial Artery Compliance in Patients with Peripheral Vascular Disease." Vascular Medicine 2, no. 1 (February 1997): 8–12. http://dx.doi.org/10.1177/1358863x9700200102.

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Compliance in largely central arteries of patients with peripheral vascular disease (PVD) has been reported to be reduced. However, the arterial tree is an inhomogeneous system, and there remains uncertainty about whether the peripheral arteries (e.g. the medium-sized muscular radial artery) undergo a similar change to the central arteries. The aim of this study was to investigate the radial artery elasticity in 19 patients with PVD compared with 18 normal subjects of comparable age and sex. Using a noninvasive high-resolution echo-tracking device coupled to a photoplethysmograph (Finapres system) allowing simultaneous arterial diameter and finger blood pressure monitoring, we measured the radial artery compliance by determining the diameter–pressure, compliance–pressure and distensibility–pressure curves. The results showed that the diameter of the radial artery was similar in the two groups, but that the compliance and distensibility were not further reduced in patients with PVD than in the normal controls at 100 mmHg and for a common blood pressure range. The present studies demonstrate that in patients with PVD the radial arterial compliance is not reduced, which indicates that the change in arterial elasticity is not identical. The potential mechanisms involved in this change in radial artery compliance are discussed.
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C., Prasad, and Santosh Nayak K. "Clinical study of peripheral arterial occlusive disease of lower extremities." International Surgery Journal 5, no. 4 (March 23, 2018): 1388. http://dx.doi.org/10.18203/2349-2902.isj20181116.

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Background: Peripheral arterial occlusive disease or commonly known as peripheral arterial disease (PAD) comprises those entities which result in obstruction to blood flow in the arteries, exclusive of the coronary and intracranial vessels and the term is usually applied to disease involving the arteries of lower extremity. Peripheral arterial disease is an important manifestation of atherosclerosis involving the arteries of legs. Vascular surgeons continue to encounter complications of atherosclerosis as their most common clinical challenge. Objective of this study was to know the various etiologies and different clinical presentation of Peripheral arterial occlusive disease.Methods: This was a cross sectional observational study of 50 cases diagnosed with Peripheral Arterial disease of the lower extremities, done during the period from January 2013 to June 2014 among the Patients with Peripheral Arterial disease of the lower extremities admitted to surgical wards of SCBMCH, Cuttack.Results: All the cases in the present study fall under the category of chronic lower limb ischemia and no cases of acute limb ischemia. Majority of the cases in atherosclerosis were above the age of 50 years, while in the TAO group majority belong to the age group between 31 to 50 years. TAO was usually limited to the distal part of the limb. All patients with TAO had a history of smoking and 61% of atherosclerotic patients gave history of smoking.Conclusions: TAO and Atherosclerosis are the etiologies for ischemia in these cases, with atherosclerosis being more common of the two. TAO presented at a younger age group whereas atherosclerosis presented in the older age group.
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Haider, Rehan. "Peripheral Vascular Disease." Cardiology Research and Reports 5, no. 4 (September 29, 2023): 01–13. http://dx.doi.org/10.31579/2692-9759/104.

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Peripheral vascular disease comprises diseases of the arteries and veins outside the thoracic region.: peripheral arterial disease (PAD), carotid artery disease (CAD), and aortic aneurysmatic disorder (AAA). Other rare manifestations of atherosclerotic disorders (e.g., renovascular high blood pressure, abdominal angina, and ischemia of the top extremity) were briefly noted. Special concerns in patients with diabetes are addressed in relevant sections; for instance, infection in an ischemic foot in an affected person with diabetes is described within the phase of critical limb ischemia. Atherosclerosis is the primary cause of peripheral arterial vascular ailments. It is vital to appreciate that the pathogenic mechanisms of clinical atherosclerosis are dual: chronic obstruction and biotic. The chronic obstructive mechanism is the primary purpose of lower limb ischemia, and in patients with diabetes, it is far more regularly preceded by a thrombotic occasion. An affected person with moderate clay diction abruptly studies significantly shortening of walking distance or surprising onset of rest ache. Alternatively, the seemingly wholesome character develops claudication. A coronary period heart attack or stroke in an affected person with claudication is also a thrombotic event in a patient with chronic obstructive disorder. In general, patients with diabetes greater frequently develop symptoms of atherosclerotic headaches, they do it at a younger age and it may be greater difficult to treat and feature greater headaches with treatment (in particular with invasive treatment.
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Dissertations / Theses on the topic "Peripheral arteries disease"

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Lewis, M. H. "Peripheral arterial disease from aetiology to surgical management." Thesis, University of South Wales, 2013. https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html.

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The work presented includes over thirty peer reviewed published manuscripts based on studies undertaken during my surgical career. As Principal Investigator, I led the study conception/design/data acquisition/analysis/interpretation and was involved with writing the final drafts of all manuscripts prior to their formal submission to high impact factor peer-reviewed specialist journals. The thesis is divided into subsections reflecting my development and different interests within surgery. The subsections start with my learning basic research principles, moving onto clinical problem solving in general surgical dilemmas, followed by a collection of papers in my subspecialty of vascular surgery. The work culminates with a group of papers focused on aneurysmal disease, specifically, abdominal aortic aneurysms (AAA), the clinical impact of which has had a bearing on the introduction of a National AAA Screening Program in Wales in 2013. I conclude these sections with a collection of papers that reflect my long term commitment to surgical training both at regional level (as Secretary and Deputy Chairman to the Higher Surgical Training Committee and Chairman of the Basic Surgical Training Committee) and national level including my involvement with the Four Royal Colleges of Surgeons for the Intercollegiate Examinations in General Surgery. This examination is undertaken at completion of junior surgical training and used to confirm a doctor's competence for safe independent practice as a consultant. In conclusion, over forty years of academic research during my career as a vascular surgeon has provided unique insight into the pathophysiology, treatment and ultimately prevention of artherosclerotic disease. These findings have improved health policies in Wales and significantly reduced patient morbidity and mortality.
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Christman, Sharon Klopfenstein. "Intervention to slow progression of peripheral arterial disease." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054059524.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xiii, 123 p.; also includes graphics (some col.). Includes bibliographical references (p. 114-123). Available online via OhioLINK's ETD Center
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Ögren, Mats. "Vascular morbidity and mortality in men with non-invasively detected peripheral arterial disease results from the prospective population study "Men born in 1914" /." Lund : Dept. of Community Health Sciences and the Dept. of Clinical Physiology, Malmö General Hospital, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39693808.html.

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Hou, Xiang-Yu. "Exercise performance and mitochondrial function in peripheral arterial disease." Thesis, Queensland University of Technology, 2002. https://eprints.qut.edu.au/36778/1/36778_Digitised%20Thesis.pdf.

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Peripheral arterial disease (PAD) is an atherosclerotic disease in the peripheral arteries, which reduces blood supply to the lower extremities. Intermittent claudication is the symptom that develops early in PAD patients and is accompanied by the haemodynamic finding of a fall in systolic blood pressure at the ankles following exercise. In PAD patients, exercise performance is not well correlated with haemodynamic measurements and other mechanisms have been suggested to account for the impairment. There have been reports about the impaired mitochondrial metabolism (eg, decreased activities of mitochondrial enzymes) and abnormal mitochondrial structure in the skeletal muscle in PAD patients. It is not known, however, whether mitochondrial ATP production is impaired in the skeletal muscle in PAD. Whether the mitochondrial function is impaired in PAD patients, and whether the impaired mitochondrial function in the muscle contributes to the impaired exercise performance in PAD patients is unknown. The object of this work is to explore the mitochondrial function in the skeletal muscle of PAD patients and its relationship to exercise performance. Impaired exercise performance in PAD patients is evaluated using a treadmill walking performance test, which is closely correlated to patients' daily activity performance. Treadmill walking however, in addition to being influenced by local muscle factors, is influenced by central contributions, such as cardiac output and the central nervous system. As walking is limited by intermittent claudication in PAD patients localized in the legs, it would be valuable to develop a local calf muscle performance test to better understand the underlying pathophysiology in PAD. Such a protocol has not been used previously in experiments involving PAD patients. Hence, the research aim for Study 1 was to establish a calf muscle performance test protocol and to investigate its variability. Fourteen healthy control subjects and eight PAD patients undertook the maximal plantar flexion test once a week for five weeks using a Kin-Com Dynamometer. In the traditional assessment, the total impulse and peak impulse are the variables that were measured as representing the calf muscle performance. Both these variables are significantly lower in PAD patients than in controls. Alternatively, by applying simple mathematical models, the muscle function dimensions of endurance, strength and fatigability can be investigated in a single test. Compared with control subjects the PAD patients had lower muscle endurance, lower muscle strength, higher fatigue index, but no difference were found in magnitude or rate-of-fatigue. The variability of the test was different for different estimated parameters of the models, with the highest variability in muscle fatigability (rate of fatigue, CV=75% in controls) and the lowest variability in muscle strength (CV=16% in controls). The variability of the traditional assessment parameters, which included total impulse and peak impulse, was around 13% in controls and 18- 24% in PAD patients for the five tests. Based on these findings the calf muscle performance test can be applied in PAD patients to investigate different muscle function dimensions. While many of the dimensions were impaired in PAD patients compared with controls, the high variability of some of the parameters have to be considered during its application. Having established a local calf muscle performance test, the aim of Study 2 was to explore the relationship between the calf muscle performance and the traditional treadmill walking performance. Seventeen PAD patients and fourteen control subjects were tested using both the calf muscle performance test described earlier and walking performance test. The walking performance was tested using a graded treadmill protocol. The total walking time was significantly lower in PAD than that in control subjects. No variable of calf muscle performance correlated with walking performance in control subjects. However, in PAD patients, a number of calf muscle performance variables correlated with walking performance. The total impulse and the peak impulse in the best legs (higher ABI) tended to correlate with pain-time. In simple mathematical models, the muscle endurance in the worst legs (lower ABI) correlated positively with pain-walking time, and the muscle fatigue-index in the worst legs correlated negatively with total walking time. In conclusion, in PAD patients, some dimensions of calf muscle performance correlated with walking performance. This suggests that some factors of local calf muscle performance might contribute to the impaired walking performance in PAD patients. The research aim for Study 3 was to investigate a number of calf muscle physiological factors, and to ascertain their relationship with calf muscle and walking performance in PAD patients and control subjects. The physiological factors examined include ankle brachial pressure index (ABI), calf muscle weight, calf blood flow, and skeletal muscle mitochondrial ATP production rate (MAPR) in vitro. The calf muscle weight in PAD patients was significantly lower than that in control subjects. In PAD patients, the calf muscle weight was significantly lower in the worst legs than that in the best legs. The ABI was lower in PAD than in controls and significantly lower in PAD worst legs than in PAD best legs. The leg blood flow (measured by venous-occlusion plethysmography) was lower in PAD than that in controls, but there was no significant difference between PAD best legs and PAD worst legs. The MAPR was measured using different substrate combinations. The MAPR (PM, pyruvate + malate), MAPR (PCM, palmitoyl-carnitine + malate) and MAPR (PPKM, pyruvate + palmi_toyl-carnitine + alpha-ketoglutarate + malate) shows the capacity of mitochondria to produce ATP by oxidising glucose or fatty acids or both of these substrates respectively. The MAPR for the three substrate combinations in PAD patients was no different from controls. The relationship between these physiological measurements and exercise performance differed between PAD and controls. In control subjects, the calf muscle weight, ABI, leg blood flow and MAPR were not significantly correlated with walking performance, but correlated with some variables of local calf muscle performance. In PAD patients, the calf muscle weight, ABI and blood flow did not correlate with walking performance. However, the MAPR (PMkg) was positively correlated with total walking time, and MAPR (PPKMg) was positively correlated with pain-free walking time. In calf muscle performance, in the best legs, the body weight was positively correlated with total impulse and peak impulse; the calf muscle weight was positively correlated with contraction number and peak impulse; and the blood flow correlated with peak impulse. In the worst legs, the calf muscle weight and ABI were not significantly correlated with any variables; the leg blood flow was negatively correlated with contraction number; the mitochondrial protein content correlated with total impulse; the MAPR (PM) tended to correlate with peak impulse. These results suggest the importance of all these local muscle physiological factors in calf muscle performance. However, only MAPR was important in the walking performance in PAD patients. The aim of Study 4 was to further explore the relationship between MAPR and exercise performance in PAD patients after exercise training. The effect of 16 weeks of treadmill exercise training on exercise performance and MAPR was evaluated in five PAD patients. In the treadmill walking performance test, total walking time increases ranged from 100 to 150% in these five patients. The pain-free walking time increased in three patients but did not change in the other two. In the calf muscle performance test, the total impulse and contraction number increased in both legs of four patients and decreased in both legs of one patient, but the magnitude of improvement was less than 5% and the peak impulse did not change in a consistent trend. The changes in body weight, calf muscle weight, and ABI in these five patients were less than 5%. However, the increased blood flow measured by venousocclusion plethysmography in both legs ranged from 100 to 150%. The MAPR by oxidising glucose was significantly higher in trained patients than that in untrained patients, which suggested a possible change in mitochondrial function in response to exercise training. Such change in mitochondrial function may have a potential role in contributing to calf muscle performance and walking performance after exercise training. In summary, for the first time, a local calf muscle performance test has been established to allow better understanding of calf muscle pathophysiology in PAD patients. Using this test, it has been shown that calf muscle performance is significantly impaired in PAD patients compared with control subjects. The impairment is characterised by lower muscle endurance, lower muscle strength and higher fatigability. The impaired local calf muscle performance might contribute to the impaired overall walking performance in PAD patients. The MAPR, especially 5 through oxidising glucose, contributed to walking performance. In this pilot exercise training study, a 20 weeks exercise training program failed to improve the calf muscle performance and walking performance in PAD patients. The higher MAPR in oxidising glucose in trained PAD patients again suggested the importance of muscle glucose oxidation as a contributing factor in the exercise performance in PAD patients.
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Barker, Glenn A. "Carbohydrate metabolism in peripheral arterial disease." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/36790/1/36790_Digitised%20Thesis.pdf.

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Peripheral arterial disease results in varying degrees of functional disability. Although principally a disease of the vascular tree, evidence demonstrates a significant contribution from metabolic alterations within ischaemically affected skeletal muscle. This thesis was concerned with better characterising the nature of these metabolic alterations, and their contribution to the functional disability in PAD patients. It also examined the efficacy of dietary carbohydrate supplementation as a therapeutic intervention in PAD. The activity of the pyruvate dehydrogenase complex (PDH) is an important determinant of carbohydrate metabolism, experiment I examined the possibility that the active fraction of PDH (PDHa) is lower than normal in skeletal muscle of patients with intermittent claudication (IC) or patients with chronic limb ischaemia and rest pain (RP). A resting muscle biopsy was taken from the medial gastrocnemius of 11 patients with IC, seven patients with RP and eight healthy control subjects (CON). Biopsies were analysed for PDHa, acetylcarnitine, glycogen and phosphocreatine. In the RP group resting PDHa was 60 percent lower than CON (0.19 ± 0.21 versus 0.53 ± 0.27 mmol.min·1.kg·1 wet wt), but not significantly different (p = 0.09) from IC (0.42 ± 0. i 7 mmol.min·1.kg·1 wet wt); PDHa was not different between IC and CON (p = 0.54). There was no difference in muscle acetylcarnitine and glycogen between the groups, nor were there any associations between PDHa and resting acetylcamitine. Further work is warranted in determining the significance of the reduction in PDHa in the RP group, its relationship to symptoms and amenability to treatment. Study two examined the extent to which resting metabolic changes within ischaemic muscle account for the exercise intolerance in PAD patients with intermittent claudication. Specifically, study two tested the hypothesis that walking intolerance in intermittent claudication (IC) is related to both slowed whole body V02 kinetics and depressed activity of the active fraction of pyruvate dehydrogenase (PDHa) in skeletal muscle. Ten patients displaying IC and eight healthy controls performed two familiarisation and then three maximal incremental walking tests. From these tests averaged estimates of walking time, peak V02 and the time constant of V02 ('t) during submaximal walking were obtained. A muscle sample was taken from the medial gastrocnemius muscle at rest and analysed for PDHa and several other biochemical variables. Walking time and peak V02 were -50 percent lower in IC than controls, and 't was 2-fold higher (p < 0.05). 't was significantly correlated with walking time (r = - 0.72) and peak V02 (r = -0.66) in IC; but not in controls. Resting muscle PDHa tended to be correlated with 't (r = -0.56; p = 0.09) in IC; but not in controls (r = -0.14). A similar correlation was observed between resting ABI and 't (r = -0.63, p = 0.05) in IC. This data demonstrates that impaired V02 kinetics contribute to the reduced walking capacity in IC, and that slowed V02 kinetics may result from both haemodynamic and metabolic factors in claudicants. The final experiment examined the effects of a three-day dietary carbohydrate supplementation regime on walking capacity in claudications and in healthy control subjects. Previous work has demonstrated an ergogenic effect of CHO loading in claudicants, but failed to accurately quantify the magnitude of the improvement in walking capacity, or potential mechanisms involved in the effect. Continuing from study II, eleven PAD patients with intermittent claudication and eight control subjects performed a further two maximal treadmill tests, each preceded by a three day supplemental period. In a randomised blinded fashion, all subjects consumed a total of 700g of glucose polymer dissolved into 6 L of water (CHO), or an equal volume of artificially sweetened water (PLAC) (2Uday with meals). From baseline, walking time was significantly improved in the IC group (660 ± 331 s to 697 ± 313 s) and significantly reduced in the CON group (1335 ± 264 s to 1290 ± 250 s) following CHO. In the IC group the improvement in walking capacity was inversely associated with the initial walking capacity of the patient (r = -0.73, p < 0.05) such that for patients with an initial walking capacity of less than 400 s (n=4) there was a 23% improvement following CHO. Resting, steady state, peak V02 and the kinetics of the transitional response ('t) were unaffected by CHO, however there was an association between the change in walking time and change in 't in the IC group only (r = -0.70, p < 0.05). Resting, steady-state and maximal RER was significantly elevated following CHO in both groups. In the CON group the reduction in walking time was strongly associated with increases in body weight (r = 0.87, p < 0.05). There was no association between the change in walking performance and any muscle measure in the CON group, but in IC the improvement in walking time was inversely associated with resting PDHa (r = -0.65, p < 0.05). This data demonstrates the benefits of CHO supplementation are mainly confined to those patients with greater functional impairments and may be mediated via improvements in V02 uptake kinetics resulting from metabolic alterations within the exercising musculature.
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Insall, R. L. "Pulse waveforms and transit time from photoelectric plethysmography in the diagnosis of peripheral vascular disease." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309069.

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Sanderson, Brad E. "Supervised stationary cycling versus supervised treadmill-walking for periperal arterial disease /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18988.pdf.

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Collins, Patrick William Hugh. "Assessing the severity of lower limb ischaemia and the thrombo-inflammatory response to surgery and exercise in peripheral arterial disease." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted contains 3rd party material and therefore cannot be made available electronically until Jan. 1, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=53369.

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Thesis (M.D.)--Aberdeen University, 2008.
With: Surgical revascularisation in patients with severe limb ischaemia induces a pro-thrombotic state / P. Collins ... et al. Platelets. 2006: 17(5), 311-317. With: A preliminary study on the effects of exercising to a maximum walking distance on platelet and endothelial function in patients with intermittent claudication / P. Collins ... et. Eur. J. Vasc. Endovasc. Surg. 2006: 31, 266-273. Includes bibliographical references.
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Gallagher, Ryan Robert. "THE IMPACT OF OUTWARD REMODELING ON VASODILATION IN SKELETAL MUSCLE RESISTANCE ARTERIES." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/914.

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Peripheral arterial occlusive disease (PAOD) is an ischemic disease characterized by narrowing of the peripheral arteries due to the accumulation of atherosclerotic plaque in the inner lining of the vessels, which disrupts blood flow to downstream tissues. Blood can be redirected into collateral vessels, natural bypasses around arterial occlusions, causing shear-induced outward remodeling of the vessels. The enlarged vessels facilitate transfer of increased blood flow to downstream tissues. The remodeling process, however, may impair vasodilation, which in turn may cause or contribute to intermittent claudication- transient pain brought on by locomotion. To stimulate the growth of collateral arteries, the femoral arteries of young, otherwise healthy mice were ligated distally to the profunda femoris, the stem to the gracilis collateral circuit. The diameter of the profunda femoris artery was measured at rest and following gracilis muscle contraction 7 and 28 days post-surgery using intravital microscopy. Enlarged resting diameter, consistent with collateral enlargement, and impaired vasodilation was observed at day 7, but not at day 28. To determine if impaired functional vasodilation is due to impaired endothelial- or smooth muscle-dependent responses during outward remodeling, cell-dependent vasodilators were applied to the hindlimb. Endothelial- and smooth muscle-dependent vasodilation was significantly impaired 7 days post-ligation, but not 28 days after. This data supports the hypothesis that smooth muscle dysfunction causes impaired functional vasodilation in the early stages of collateral enlargement.
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Wong, Shen. "The measurement of platelet function in response to 3 common antiplatelet regimens in patients with peripheral occlusive arterial disease." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/27942.

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Background: Anti-platelet therapy reduces vascular complications in patients with peripheral occlusive arterial disease (POAD) with aspirin the most commonly prescribed agent. However, aspirin resistance can be observed in patients who suffer clinical thromboembolic events, or have persistent platelet activity despite regular aspirin treatment. The clinical benefits of clopidogrel or combination aspirin and clopidogrel therapy may be due to superior platelet inhibition or the inhibition of platelets in aspirin resistant patients. Aim: To investigate the effects of aspirin, clopidogrel, and combination therapy on platelet inhibition in patients with POAD, and to test the response of laboratory defined aspirin resistant patients to alternative antiplatelet therapies. Methods: 50 patients were recruited from the vascular outpatient clinic at Royal North Shore hospital, at the consulting rooms of Royal North Shore Hospital vascular surgeons and the associated vascular imaging laboratories. Patients with confirmed symptomatic peripheral vascular disease were randomised to receive either aspirin or clopidogrel for 2 weeks, followed by 2 weeks of combined aspirin and clopidogrel therapy. Patients were then asked to “crossover” to the alternative antiplatelet monotherapy for the final two weeks of the trial. After each 2 week course of antiplatelet therapy, platelet activation was flow cytometrically determined by detecting platelet membrane expression of the activation markers CD62P, PACl, fibrinogen receptor and platelet-leukocyte aggregates. Measurements were performed after the addition of PGE, (for resting activation levels), and after platelet activation by low and high dose (0.5&5uM) ADP. Global platelet function was assessed using the Platelet Function Analyser-100 (PFA-lOO) with the Collagen/Epinephrine and the Collagen/ADP cartridges. Results: By flow cytometry, no significant differences in activation marker expression between aspirin, clopidogrel and combination treated patients were detected in the PGE, treated control groups. There were statistically significant differences in levels of all platelet activation markers expressed between the three antiplatelet therapies (ANOVA, p<0.001), with clopidogrel and combination therapy significantly reducing expression after both low and high dose ADP compared to aspirin (Wilcoxon p<0.05). No significant differences in marker expression were observed between clopidogrel and combination therapies. With the PFA-lOO, 9 of 50 (18%) patients were aspirin resistant by the Coll/Epi cartridge. Six of 9 aspirin resistant patients became sensitive to aspirin after combination antiplatelet therapy. Both PFA-lOO cartridges were insensitive to clopidogrel monotherapy. Statistically significant differences in Coll/ADP closure times were seen between combination therapy and aspirin (Wilcoxon p=0.0102). There was no significant difference in median levels of flow cytometric platelet activation between aspirin resistant and sensitive patients (Mann-Whitney p>0.05). Conclusions: Clopidogrel and combination therapy significantly inhibit platelet activation compared to aspirin in patients with POAD, but no significant difference in platelet inhibition was observed between clopidogrel and combination therapy. A significant proportion of POAD patients were resistant to aspirin by PFA-l 00. The majority of these patients became sensitive to aspirin with combined aspirin and clopidogrel therapy.
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Books on the topic "Peripheral arteries disease"

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Svante, Horsch, and Vleeschauwer Philippe de, eds. Topics in peripheral arterial disease. München: W. Zuckschwerdt Verlag, 1989.

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Alonso, Alvaro. Peripheral vascular disease. Sudbury, Mass: Jones and Bartlett Publishers, 2011.

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Alonso, Alvaro. Peripheral vascular disease. Sudbury, Mass: Jones and Bartlett Publishers, 2011.

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David, McManus, and Fisher Daniel Z, eds. Dx/Rx peripheral arterial disease. Sudbury, Mass: Jones and Bartlett Publishers, 2011.

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1928-, Coffman Jay D., and Eberhardt Robert T. MD, eds. Peripheral arterial disease: Diagnosis and treatment. Totowa, N.J: Humana Press, 2003.

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Owens, Christopher D., and Yerem Yeghiazarians. Handbook of endovascular peripheral interventions. New York: Springer, 2012.

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Leachman, D. Richard. Coronary and peripheral angiography and angioplasty. London: Edward Arnold, 1989.

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Coffman, Jay D., and Robert T. Eberhardt. Peripheral Arterial Disease. New Jersey: Humana Press, 2002. http://dx.doi.org/10.1385/1592593313.

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Dieter, Robert S. Peripheral Arterial Disease. New York: McGraw-Hill, 2009.

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1970-, Dieter Robert S., Dieter Ray A. 1934-, and Dieter Raymond A. 1962-, eds. Peripheral arterial disease. New York: McGraw-Hill, 2009.

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Book chapters on the topic "Peripheral arteries disease"

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Safar, Michel E. "Arterial Stiffness and Peripheral Arterial Disease." In Atherosclerosis, Large Arteries and Cardiovascular Risk, 199–211. Basel: KARGER, 2006. http://dx.doi.org/10.1159/000096731.

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Justino, Henri, and Athar M. Qureshi. "Reopening of Peripheral and Central Arteries and Veins." In Cardiac Catheterization for Congenital Heart Disease, 355–73. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5681-7_23.

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Justino, Henri, and Athar M. Qureshi. "Reopening of Peripheral and Central Arteries and Veins." In Cardiac Catheterization for Congenital Heart Disease, 431–48. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69856-0_27.

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Justino, Henri, and Athar M. Qureshi. "Reopening of Peripheral and Central Arteries and Veins." In Atlas of Cardiac Catheterization for Congenital Heart Disease, 129–37. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-72443-0_15.

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Justino, Henri. "Correction to: Reopening of Peripheral and Central Arteries and Veins." In Atlas of Cardiac Catheterization for Congenital Heart Disease, C3. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-72443-0_47.

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Stühlinger, Markus C., and Philip S. Tsao. "Etiology and Pathogenesis of Atherosclerosis." In Peripheral Arterial Disease, 1–19. Totowa, NJ: Humana Press, 2003. https://doi.org/10.1007/978-1-59259-331-6_1.

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Eberhardt, Robert T., and April Nedeau. "Perioperative Cardiac Evaluation and Management for Vascular Surgery." In Peripheral Arterial Disease, 243–64. Totowa, NJ: Humana Press, 2003. https://doi.org/10.1007/978-1-59259-331-6_14.

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Strandness, D. E. "Hemodynamics and the Vascular Laboratory." In Peripheral Arterial Disease, 55–73. Totowa, NJ: Humana Press, 2003. https://doi.org/10.1007/978-1-59259-331-6_4.

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White, Christopher J. "Endovascular Therapy." In Peripheral Arterial Disease, 203–23. Totowa, NJ: Humana Press, 2003. https://doi.org/10.1007/978-1-59259-331-6_12.

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Menzoian, James O., and Joseph D. Raffetto. "Surgical Revascularization." In Peripheral Arterial Disease, 225–42. Totowa, NJ: Humana Press, 2003. https://doi.org/10.1007/978-1-59259-331-6_13.

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Conference papers on the topic "Peripheral arteries disease"

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K, Arunkumar, Mallireddy Venkata Nithin Reddy, and Manamasi Bhavya. "AI-Powered Wrist Ultrasound for Peripheral Arterial Disease." In 2024 Second International Conference on Intelligent Cyber Physical Systems and Internet of Things (ICoICI), 1630–34. IEEE, 2024. http://dx.doi.org/10.1109/icoici62503.2024.10695998.

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Patel, Vedanshi, John Hanks, and Amir Tofighi Zavareh. "Machine learning-enhanced wavelength detection for point-of-care optical devices in tissue oxygenation and peripheral arterial disease assessment." In Optical Diagnostics and Sensing XXV: Toward Point-of-Care Diagnostics, edited by Justin S. Baba and Gerard L. Coté, 17. SPIE, 2025. https://doi.org/10.1117/12.3040746.

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Barquero-Pérez, O., R. Goya-Esteban, E. Sarabia-Cachadiña, and J. Naranjo-Orellana. "Comparative Analysis of Generalized Multiscale Entropy Methods for Coarse-Grained Time Series Construction in Assessing Autonomic Balance in Peripheral Arterial Disease Patients." In 18th International Conference on Bio-inspired Systems and Signal Processing, 893–98. SCITEPRESS - Science and Technology Publications, 2025. https://doi.org/10.5220/0013165000003911.

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Singal, Ashish, Clarence Ojo, and Rumi Faizer. "Characterization of Pulsatility and Temperature Profile During Reactive Hyperemic Response." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6805.

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Patients with peripheral arterial disease (PAD) have compromised blood flow to their extremities as a result of arterial narrowing. PAD is often associated with impairment in endothelial function which is exaggerated by injury from processes related to cardiovascular risk factors such as ageing, hypertension, hyperlipidemia, diabetes, smoking, and obesity [1]. Furthermore, patients with diabetes often have calcified arteries making standard non-invasive testing non diagnostic [2]. With increase in diabetes prevalence and concomitant PAD, a new non-invasive assessment method of arterial function that has the potential to reflect both arterial tone and response to ischemia reperfusion may be valuable. We have developed a peripheral arterial tonometry (PAT) system (previously described, [3]) that is capable of measuring pulsatility in peripheral digits. We complemented our system with simultaneous peripheral temperature measurements that could not only add value in understanding PAD, but also aid in clinical diagnoses. In this investigation, we characterized our system on healthy individuals before using it on patients suffering from arterial disease in future investigations.
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Aragão, José Aderval, João Víctor Santos Gomes, Larissa Santos Silva, Felipe Matheus Sant'Anna Aragão, Iapunira Catarina Sant'Anna Aragão, Bárbara Costa Lourenço, and Francisco Prado Reis. "Occurrence of anxiety and depression in patients with peripheral arterial obstructive disease." In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-112.

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Context: neuropsychiatric diseases correlate with biological risk factors, such as systemic arterial hypertension, diabetes mellitus, stroke and cardiovascular diseases, which can lead to suffering, physical and labor disability of the individual. Within this context, there is a high number of cases of peripheral obstructive arterial disease (poad) within a population affected by some depressive disorder, so if untreated, there is a tendency to have a disability and even mortality of this individual, whether for psychic or physical reasons. From this perspective, the theme is extremely relevant due to few studies that address the correlation between anxiety or depression with poad. Objective: to determine the occurrence of anxiety and depression in patients with poad. Methodology: this was a descriptive, observational, cross-sectional study conducted in the vascular surgery department of a tertiary hospital. All patients with poad included in the study for clinical or surgical treatment were evaluated through clinical history, physical examination and through the ankle-brachial index-itb, where systolic blood pressure was measured in the brachial, posterior tibial and pedicle arteries, with the patient in the supine position and at room temperature to avoid peripheral arterial vasoconstriction. The hospital anxiety and depression scale (hads) was used to assess anxiety and depression. Results: the prevalence of anxiety in patients with poad was 24.3%, while depression was 27.6%. It was observed that there was an association of both anxiety and depression in patients with low monthly family income, smoking, systemic arterial hypertension, and were more prevalent in females. Conclusion: there is a high prevalence of anxiety and depression among patients with poad. These when not adequately treated, increase their secondary risks, mainly by increasing the chances of chronic vascular diseases, often predisposing to suicide.
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Denny, W., B. O’Connell, J. Milroy, and M. Walsh. "Drug Eluting Stents: Modelling the Physics of Mass Transport in the Arterial Wall." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19107.

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Coronary artery disease (CAD), which results in inadequate blood flow to the heart, is responsible for 1 in every 4.8 deaths in the USA (Lloyd-Jones et al., 2009). Currently, there are 16.5 million patients with stable angina and 500,000 new diagnoses annually (Gibbons et al., 2003). CAD has been linked with atherosclerosis since the early 20th century (McMahan et al., 2008) and refers to the localisation of the disease in the coronary arteries. Atherosclerosis is a degenerative disease that affects not only the coronary arteries, but also the carotid and other peripheral arteries in the body.
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Bennetts, Craig J., Ahmet Erdemir, and Melissa Young. "Surface Stiffness of Patient-Specific Arterial Segments With Varying Plaque Compositions." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16132.

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Peripheral arterial disease (PAD), resulting from the accumulation of plaque, causes obstruction of blood flow in the large arteries in the arm and leg. In the United States, approximately 8.4 million people over the age of 40 have PAD [1]. If not treated, PAD can cause ischemic ulcerations and gangrene, which could eventually lead to amputation. Approximately, 25% of patients with PAD have worsening limb symptoms over 5 years, 7% requiring revascularization, and 4% requiring amputation [2].
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Back, Martin R., and Rodney A. White. "Intravascular Ultrasound in Imaging Diseased Arteries." In ASME 1996 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/imece1996-1316.

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Abstract Development of miniaturized piezoelectric transducers positioned at the end of intraluminal catheters have allowed high resolution, ultrasonic imaging of various cardiac, vascular and hollow organ structures. Current intravascular ultrasound (IVUS) catheters provide real-time, luminal and transmural cross-sectional imaging in large vessels with dimensional accuracy. Present applications of IVUS include imaging in arterial occlusive disease, aneurysms and traumatic injuries. Intravascular ultrasound can delineate wall morphology, lesion shape, volume and length and branch configurations. Concomitant rapid expansion of minimally-invasive endovascular therapies in coronary and peripheral vasculature have added new role for IVUS. In addition to diagnostic information, IVUS enables choice of appropriate angioplasty technique, endovascular device guidance and controlled assessment of the efficacy of interventions. Real time IVUS imaging can only be utilized during invasive diagnostic and therapeutic procedures after vascular access is established. Further acceptance and implentation relies upon the effectiveness of IVUS in improving endovascular outcomes and minimizing periprocedural complications as compared to alternative imaging modalities.
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O’Connell, Barry M., Tim M. McGloughlin, and Michael T. Walsh. "Experimental Validation of the Influence of Stent Strut Compression on Artery Wall Drug Mass Transport." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206622.

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Atherosclerosis is a degenerative disease that affects coronary, carotid and other peripheral arteries in the body. Arterial occlusions ensuing from aggressive atherosclerotic plaque progression can often culminate in an ischemic attack, such as an apoplectic attack or a myocardial infarction [1–3]. Several interventional procedures are available to the clinician but in recent years drug eluting stents (DES) have become the preferred choice and by the beginning of 2006 more than 8 out of 10 coronary stents were DES [4] at a cost of between $4 and $5 billion annually [5].
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Breeher, L. E., Saikrishna Marella, H. S. Udaykumar, and K. B. Chandran. "Computational Modeling and Simulation of Atherosclerotic Plaque Growth." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32481.

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Research has been conducted by the authors with the objective to produce a computational model that will clearly display the coupled nature of the hemodynamics/fluid mechanics of blood flow and atherosclerotic plaque growth in the human carotid artery. The motivation for this investigation is the serious nature of atherosclerosis. Atherosclerosis is an inflammatory disease, which occurs in medium and large size arteries. Among the many effects stemming from the disease are heart attack, stroke, ischemia, and peripheral vascular disease. In healthy arteries, the collagen and elastin allow the artery to expand and contract with blood flow. This function enables the artery to maintain constant wall shear stress [1]. Plaque existence in the arterial wall results in decreased ductility of the wall, which inhibits the wall from maintaining constant shear stress. Plaque formations along the arterial wall then protrude into the artery, disturbing the blood flow. Characteristics of the fluid flow in the artery are also altered due to the presence of a plaque. Areas of low shear stress and recirculation move downstream from the plaque. These disturbances act not only to further the plaque formation at the site, but also to make the wall around the plaque formation more prone to lesions that could lead to new plaque initiation. Complex characteristics of the blood flow give areas of an artery such as bends and bifurcations a predisposition for the disease, whereas plaques affect blood flow, creating flow patterns that promote new plaque initiation. This interdependency makes atherosclerosis a very serious disease and one which is of great importance in research.
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Reports on the topic "Peripheral arteries disease"

1

Alshammari, Mohammed Kanan. Efficacy of Complementary and Alternative Medicine in Peripheral Arterial Disease: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2023. http://dx.doi.org/10.37766/inplasy2023.3.0001.

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Review question / Objective: To explore various CAM therapies available and to generate evidence that these therapies are effective for managing the disease. Condition being studied: Peripheral arterial disease (PAD) is described as the atherosclerotic process of arteries other than cerebral and coronary arteries i.e. the abdominal aorta, iliac, and arteries of the lower limb which leads to the narrowing and blocking of arteries. Information sources: An online systematic literature search will be done from the time of database inception from 5 electronic databases namely PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Ovid SP, ISI Web of Science, Elsevier Science Direct, and Wiley Online Library.
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Zhang, Ruizhe, and Qingya Xie. A meta-analysis of cholesteryl ester transfer protein(CETP) gene rs708272(G>A) polymorphism in association with cornoary heart disease risk. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2023. http://dx.doi.org/10.37766/inplasy2023.6.0021.

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Review question / Objective: To seek the association of the CETP rs708272 polymorphism with CHD.To figure out if the carriers of allele rs708272-A reduce or increase the risk of CHD in comparison with carriers of allele rs708272-G under allele model, dominant model and recessive model. Condition being studied: The inclusion criteria of CHD:(1)the presence of stenosis≥50% in a minimum of one main segment of coronary arteries (the right coronary artery, left circumfex, or left anterior descending arteries) by coronary angiography.(2) symptoms representing angina pectoris, electrocardiographic changes, and elevations of cardiac enzymes based on the criteria of the World Health Organization. (3) a certifed record of coronary artery bypass graft or percutaneous coronary intervention were included in the study.The exclusion criteria of CHD :patients with congenital heart disease, cardiomyopathy, and valvular disease.Controls:the same populations as the cases and specifed to be without CAD, cardiovascular and cerebrovascular diseases, and peripheral atherosclerotic arterial disease.
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Smolderen, Kim, John Spertus, Dave Safley, Mehdi, Shishehbor, Mansoor Qureshi, Peter ,. Soukas, Dawn Abbott, et al. Treatment and Patient Characteristics Affecting the Health Status of Patients with Peripheral Arterial Disease ‐‐ The PORTRAIT Study. Patient‐Centered Outcomes Research Institute (PCORI)., April 2019. http://dx.doi.org/10.25302/4.2019.ce.13046677.

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Baribeau, Vincent, Brianna Krafcik, Aravind Ponukumati, and Philip Goodney. Protocol for "Independent Amputation Risk Factors in Patients with Concomitant Diabetes Mellitus and Peripheral Arterial Disease: A Systematic Review ". INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2023. http://dx.doi.org/10.37766/inplasy2023.12.0115.

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Drug coated balloons have some short-term benefits for peripheral arterial disease. National Institute for Health Research, January 2017. http://dx.doi.org/10.3310/signal-000358.

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Rivaroxaban plus aspirin may reduce heart attack and strokes in people with peripheral arterial disease, but with an added risk of bleeding. National Institute for Health Research, February 2018. http://dx.doi.org/10.3310/signal-000554.

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