Journal articles on the topic 'Periodontitis Research'
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Nishihara, Tatsuji. "Basic research on macrophages in periodontitis." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 60, no. 4 (December 28, 2018): 167–72. http://dx.doi.org/10.2329/perio.60.167.
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Khomich, S., B. Kritsky, and A. Khomich. "Morphological research of chronic apical periodontitis." International Journal of Oral and Maxillofacial Surgery 38, no. 5 (May 2009): 573. http://dx.doi.org/10.1016/j.ijom.2009.03.615.
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Kordiyak, Olena J. "Periodontal Destruction and Regeneration in Experimental Models: Combined Research Approaches." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 5 (October 24, 2020): 28–34. http://dx.doi.org/10.26693/jmbs05.05.028.
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Chronic periodontitis is a common dental disease, resulting in destruction of gingival tissue, periodontal ligament, cementum, alveolar bone and, consequently- teeth loss in the adult population. Experimental animal models have enabled the study of periodontal disease pathogenesis and are used to test new therapeutic approaches for treating the disease The purpose of this review study was to draw the evidence from animal models, required for future assessment of destructional and regenerative processes in periodontal tissues. Material and methods: a rat experimental periodontitis models of ligature, streptozotocin, and immune complexes induced periodontitis, periodontal defect, altered functional loading, stress exposures and surgically created chronic acid reflux esophagitis models. Histomorphomorphological/-metrical, immunohisto (-cyto)chemical and histopathological analysis, micro-computed tomography, scanning and transmission electron microscopy, polarizing light and confocal microscopy, spectrophotometry, radiographic and biomechanical analysis, descriptive histology and computer-assisted image analysis. Results and discussion. Scaling and root planing may not always be effective in preventing periodontal disease progression, and, moreover, with currently available therapies, full regeneration of lost periodontal tissues after periodontitis cannot be achieved. However, in 70.5% of the results of experimental studies reported, irrespective of the defect type and animal model used, beneficial outcome for periodontal regeneration after periodontal ligament stem cell implantation, including new bone, new cementum and new connective tissue formation, was recorded. Therefore, platelet-rich fibrin combined with rat periodontal ligament stem cells provides a useful instrument for periodontal tissue engineering. Conclusion. There is sufficient evidence from preclinical animal studies suggesting that periodontal tissue engineering would provide a valuable tool for periodontal regeneration. Further elaboration of the developed in preclinical studies experimental techniques should justify progress to clinical studies and subsequent medical application
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Natto, Zuhair S., Randa H. Abu Ahmad, Lina T. Alsharif, Hanan F. Alrowithi, Duaa A. Alsini, Hetaf A. Salih, and Nabil F. Bissada. "Chronic Periodontitis Case Definitions and Confounders in Periodontal Research: A Systematic Assessment." BioMed Research International 2018 (November 28, 2018): 1–9. http://dx.doi.org/10.1155/2018/4578782.
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Case definitions and criteria of periodontal diseases are not yet consistent worldwide. This can affect the accuracy of any comparison made between two studies. This study determines which are the most common chronic periodontitis case definitions as well as confounding variables that have been reported worldwide in periodontal literature. A systematic assessment on periodontal disease classification and confounders was conducted using all publications in MEDLINE, EMBASE, SCOPUS, and Google Scholar between 1965 and October 2017. Screening of eligible studies and data extraction were conducted in duplicate and independently by two reviewers. The search protocol produced 4,218 articles. Out of these, 492 potentially relevant articles were selected for review. Only 351 studies fulfilled the selection criteria. Combination of probing depth and clinical attachment loss was the most common chronic periodontitis case definitions used (121, studies, 34.5%). CPI/CPITN was the most common classification used. Age was the most common confounder studied in periodontal research (303 studies, 86.3%), followed by gender (268 studies, 76.4%) and race (138 studies, 39.3%). Albumin and creatinine were the least common variables studied (1 or 2 studies each). Different case definitions affect the prevalence and treatment consequences of periodontitis. We need to standardize periodontitis case definitions worldwide to avoid difficulties in case diagnosis and prognosis. Further studies need to be done to assess the association between periodontitis and several potential confounders.
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Ali, Syed Muhammad, and Syed Mahmood Haider. "PERIODONTAL STATUS." Professional Medical Journal 25, no. 12 (December 8, 2018): 1961–65. http://dx.doi.org/10.29309/tpmj/18.4382.
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Thalassemia is a worldwide disease. 5-8% of Pakistani population (approx. 8–10 millions) are carrying thalassemia genes. It causes various abnormalities in different organs of patients. In Pakistan (to the best of our knowledge) no research work on oral and maxillofacial manifestation has been carried out, therefore present study was under taken. Setting: Abbasi Shaheed Hospital Karachi with collaboration of Husaini Institute of Blood Diseases Karachi, Fatimid Foundation and National institute of Oral Diseases Karachi Pakistan. Period: 2 years June 2013 to June 2015. Objectives: To assess the prevalence of periodontal disease and compare with age in thalassemia patient. Study Design: The sample consisted of 200 patients with Thalassemia Major, 120 males and 80 females aged 5 to 35years, with the mean age18.1. The sample was divided into three subgroups according to age. Clinical examination were carried out to assess the prevalence of change statistical differences in frequencies of percentage between the three groups. Aims of study: The aim of this study was to evaluate the frequency of periodontal status of Thalassemic patients and correlate with age from population of Karachi. Methods and Materials: 200 diagnosed β – thalassemia major patients, were randomlyselected form the Patients who were registered for their treatment. Their clinical examination and percentage of recorded feature were calculated and cross tabulated with age and (Ramfjords PDI Index) were used for evaluation of periodontitis and result were deduced. Results: Themost prominent features recorded were periodontitis in 82.5 normal patients were 17.5, Mild periodontitis 45.5% %; Moderate periodontitis 30 %; Severe periodontitis 7%. Conclusion: The increase in severity of Periodontistis increases with age and duration, necessitate regular surveillance and counselling in order to reassure the patient, reduce Periodontitis in thalassemia patients and improve the overall condition and life style of Patients.
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Zholdoshev, Ch, K. Kuttubaeva, R. Alymbaev, E. Suerkulov, and T. Abdyshev. "Indicators of Microbiological Research in Generalized Chronic Periodontitis." Bulletin of Science and Practice 7, no. 10 (October 15, 2021): 231–35. http://dx.doi.org/10.33619/2414-2948/71/25.
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The state of microflora in generalized chronic periodontitis was studied according to the data of KSMA the Department of Therapeutic Dentistry for the period of 2020. A total of 102 patients were examined.
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Ycaza Béjar, María Gracia, and Carlos Xavier Ycaza Reynoso. "Control of glucose levels in patients with periodontitis in the ucsg periodontics clinics semester a-2019." Journal of America health 3, no. 1 (January 6, 2020): 31–39. http://dx.doi.org/10.37958/jah.v3i1.25.
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Objective: Diabetes is considered a modifier of periodontal disease; it is important to consider HbA1c in patients with periodontal disease in order to determine the degree of progression found by patients in the periodontics clinics I and II of the UCSG Semester A 2019. Materials and Methods: cross-sectional, longitudinal and analytical research, measures prevalence of the exposure and effect of diabetes and periodontitis with a sample of 36 patients who are diagnosed with Periodontitis and who have a history of diabetes for 6 weeks, were examined in the clinical laboratory, After data collection, where all the results obtained from the research work were entered to perform the statistics obtained. Grade A decreased considerably from 44.44% to 16.67%, the percentage of patients in grade B remained at 50% while patients with grade C increased from 5.56% to 33.33%. Discussion: Of 36 patients 17 are diabetic, 13 at high risk of diabetes and 6 healthy. The age range with the highest prevalence was 50-59 years and the most prevalent gender in diabetes was 30.56% in men; After performing the HbA1c test, the diagnosis of periodontitis referring to Grade changes completely, keeping Grade B at 50% but Grade C increases to 33.33% and Grade A 16.67%.
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Lopez, Rodrigo, and Vibeke Baelum. "Classifying periodontitis among adolescents: implications for epidemiological research." Community Dentistry and Oral Epidemiology 31, no. 2 (March 14, 2003): 136–43. http://dx.doi.org/10.1034/j.1600-0528.2003.00022.x.
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Tonoyan, Lilit, Marlène Chevalier, Séverine Vincent-Bugnas, Robert Marsault, and Alain Doglio. "Detection of Epstein–Barr Virus in Periodontitis: A Review of Methodological Approaches." Microorganisms 9, no. 1 (December 29, 2020): 72. http://dx.doi.org/10.3390/microorganisms9010072.
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Periodontitis, an inflammatory condition that affects the structures surrounding the tooth eventually leading to tooth loss, is one of the two biggest threats to oral health. Beyond oral health, it is associated with systemic diseases and even with cancer risk. Obviously, periodontitis represents a major global health problem with significant social and economic impact. Recently, a new paradigm was proposed in the etiopathogenesis of periodontitis involving a herpesviral–bacterial combination to promote long-term chronic inflammatory disease. Periodontitis as a risk factor for other systemic diseases can also be better explained based on viral–bacterial etiology. Significant efforts have brought numerous advances in revealing the links between periodontitis and Epstein–Barr virus (EBV), a gamma herpesvirus ubiquitous in the adult human population. The strong evidence from these studies may contribute to the advancement of periodontitis research and the ultimate control of the disease. Advancing the periodontitis research will require implementing suitable methods to establish EBV involvement in periodontitis. This review evaluates and summarizes the existing methods that allow the detection and diagnosis of EBV in periodontitis (also applicable in a more general way to other EBV-related diseases), and discusses the feasibility of the application of innovative emerging technologies.
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Dietrich, Th, and K. Hoffmann. "A Comprehensive Index for the Modeling of Smoking History in Periodontal Research." Journal of Dental Research 83, no. 11 (November 2004): 859–63. http://dx.doi.org/10.1177/154405910408301107.
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Cigarette smoking is both a strong and common risk factor for chronic periodontitis. It is a multi-dimensional exposure that is difficult to model accurately. We propose a new comprehensive smoking index (CSI) that accounts for intensity, duration, and recency of smoking and allows for estimation of the half-life of the smoking effect. Using NHANES III data from 12,623 subjects aged 20+ yrs, we compared the performance of the CSI with that of various conventional approaches using multiple logistic regression models of chronic periodontitis. The estimate of the smoking effect’s half-life was 1.5 yrs (95% CI, 0.5–2.5 yrs). Use of the new index resulted in best model fit and the highest Wald statistic for the smoking effect on chronic periodontitis. The results suggest that use of the CSI may be a more comprehensive, efficient, and parsimonious approach to the modeling of smoking history in periodontal research.
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Mousa, Hashim Dawood. "The Effect of Olea Europaea Mouthwash on C-reactive Protein , Antioxidant in Chronic Periodontitis." Journal of duhok university 25, no. 2 (November 9, 2022): 204–9. http://dx.doi.org/10.26682/sjuod.2022.25.2.19.
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Introduction: a chronic inflammatory illness with damaging of tooth supporting structures is called periodontitis Aim: to evaluate the overall effects of Olea europaea mouthwashes as an helpful to non surgical periodontal therapy (NSPT ) on inflammation ,plaque and oxidative stress (OS) compared with chlorhexidine ( 0.2%) mouthwashes for managing of chronic periodontitis Material and methods : A study will occurred at Periodontics Department, College of Dentistry, university of Duhok , .The research composed from 72 participants with chronic periodontitis 39males, 33 females ranging from 25-55 years old, both NSPT and data collection were performed by single dentist . Randomly participants were divided into three categories , each category included 24patients,first group receiving NSPT and olive mouthwash, the second group receiving NSPT and CHX mouthwash and control group getting NSPT only. Clinical attachment loss (CAL) and Plaque Index (PI) were measured . Salivary CRP, Catalase(CAT) , eight hydroxy deoxyguanosine (8-OHdG) would be measured Results: The concentration of salivary CRP and CAT for both groups were highly significant after 2 weeks , while other parameters were non significant Conclusion Both mouthwash have a significant reduction on inflammation CRP, ,oxidative stress and consider as powerful antioxidant properties Downloads Download data is not yet available.
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Elisetti, Nirupa. "Chronic-periodontitis: could it be a connived-culprit of COVID-19?" International Journal Of Community Medicine And Public Health 8, no. 7 (June 25, 2021): 3589. http://dx.doi.org/10.18203/2394-6040.ijcmph20212621.
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Periodontitis is a multi-factorial disease resulting in the disruption of the attachment apparatus. COVID-19 has been alarming to many nations despite consistent efforts. Research has been continuously going on to curb the spread of the disease by gaining knowledge on the insights of the pathology of the disease. The current exploratory research establishes a correlation between periodontitis and COVID-19 and the impact of periodontal health in COVID affected patients. A search was performed using three data bases, PubMed, Scopus and Google Scholar published from 2019 to 2020. The keywords used for the search were COVID-19, and pathogenesis of periodontitis. The results of the search resulted in many reviews, original research, systematic reviews, case reports, etc. The critical selection of the articles especially systematic reviews was given utmost importance. Much less research has been done on the correlation of periodontitis to COVID-19. On the basis of search using the above mentioned keywords, a total of 26 articles were selected out of which only 21 articles were considered for the present exploratory review. The present review provides an insight into the pathogenic aspects of both periodontitis and COVID-19 and helps in establishing an ally which has been minimally explored to date. The pathogenesis of COVID shows a close similarity to periodontitis and henceforth a possible connection of the severity of COVID in patients suffering with chronic periodontitis. Periodontitis presents itself as a risk factor for many systemic diseases, and nevertheless, it has shown a possible similarity in the pathophysiology of COVID-19.
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Liaw, Andrew, Chun Liu, Sašo Ivanovski, and Pingping Han. "The Relevance of DNA Methylation and Histone Modification in Periodontitis: A Scoping Review." Cells 11, no. 20 (October 13, 2022): 3211. http://dx.doi.org/10.3390/cells11203211.
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Background: Periodontitis is a chronic inflammatory disease involving an interplay between bacteria, inflammation, host response genes, and environmental factors. The manifestation of epigenetic factors during periodontitis pathogenesis and periodontal inflammation is still not well understood, with limited reviews on histone modification with periodontitis management. This scoping review aims to evaluate current evidence of global and specific DNA methylation and histone modification in periodontitis and discuss the gaps and implications for future research and clinical practice. Methods: A scoping literature search of three electronic databases was performed in SCOPUS, MEDLINE (PubMed) and EMBASE. As epigenetics in periodontitis is an emerging research field, a scoping review was conducted to identify the extent of studies available and describe the overall context and applicability of these results. Results: Overall, 30 studies were evaluated, and the findings confirmed that epigenetic changes in periodontitis comprise specific modifications to DNA methylation patterns and histone proteins modification, which can either dampen or promote the inflammatory response to bacterial challenge. Conclusions: The plasticity of epigenetic modifications has implications for the future development of targeted epi-drugs and diagnostic tools in periodontitis. Such advances could be invaluable for the early detection and monitoring of susceptible individuals.
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Costa, Fernando O., Alessandra N. Guimarães, Luís O. M. Cota, André L. Pataro, Takeshi K. Segundo, Sheila C. Cortelli, and José E. Costa. "Impact of different periodontitis case definitions on periodontal research." Journal of Oral Science 51, no. 2 (2009): 199–206. http://dx.doi.org/10.2334/josnusd.51.199.
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Герасимова, Лариса, Larisa Gerasimova, Алина Юсупова, Alina Yusupova, Ирина Усманова, Irina Usmanova, Александр Сорокин, and Aleksandr Sorokin. "COMPARATIVE EFFECTIVENESS OF TREATMENT OF CHRONIC APICAL PERIODONTITIS ON THE BASIS OF DENSITOMETRIC AND MICROBIOLOGICAL RESEARCH METHODS." Actual problems in dentistry 15, no. 2 (August 9, 2019): 17–24. http://dx.doi.org/10.18481/2077-7566-2019-15-2-17-24.
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Relevanct of the research topic. One of the possible causes of apical periodontitis is the infectious inflammatory process of the periapical periodontal tissues. The microflora of the root canal system is represented by various microorganisms, among which streptococci, enterococci and staphylococci most often prevail. The complex anatomy of the root canal system ensures the growth and reproduction of microorganisms, and the endodontic treatment does not always contribute to their qualitative and quantitative reduction.
Purpose ― study of the effectiveness of endodontic treatment of chronic apical periodontitis in the near and long term.
Methods. We observed 110 patients aged 20 to 30 years with apical periodontitis, bone density analysis and microbiological examination of the contents of the root canal. Depending on the obtained clinical and laboratory data, the patients were divided into two clinical groups: in group I endodontic treatment of 55 teeth was carried out according to the scheme developed by us; in group II — 55 teeth using the standard method of treatment.
Results. In endodontic treatment of chronic apical periodontitis, treatment of the root canal system with a diode laser promotes better decontamination of the microflora. Coal mining introduction into the root canal system and in the region of the transition folds of the platelet autoplasma leads to an increase of the reparative process in the periapical region (p≤0.05).
Summary. The inclusion in the Protocol of endodontic treatment of apical periodontitis of treatment of the root canal system with a diode laser and injection of platelet autoplasm is a more effective method of treatment in comparison with the traditional one.
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Yekti, Nirmala, Yayun Siti Rochmah, and Rochman Mujayanto. "ANALISA PROFIL KADAR C-REACTIVE PROTEIN PADA STATUS KESEHATAN PERIODONTAL PASIEN DIABETES MELITUS TIPE 2 (Studi di Rumah Sakit Islam Sultan Agung Semarang)." ODONTO : Dental Journal 1, no. 2 (December 1, 2014): 19. http://dx.doi.org/10.30659/odj.1.2.19-24.
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Background: Periodontitis is the inflammation of periodontal tissue that is characterized by the migration to the apical epithelial jungsional with clinical signs of an increase in probing depth. Periodontitis is one of the oral manifestations in patients with DM. CRP is a protein alpha-globulin produced in the liver and increased levels of inflammatory process in the event. In diabetic patients increased levels of CRP resulted in periodontal tissue destruction. The purpose of this study was to determine the profile of CRP levels in patients with type 2 diabetes mellitus with periodontitis. Method: This research was conducted using analytical observational research methods. The samples used were type 2 diabetes patients with periodontitis and the control group of patients with type 2 diabetes without periodontitis in Sultan Agung Islamic Hospital . All of samples were examined periodontal index, levels of CRP and oral hygiene. Result: Mann Whitney's test show significance p=0.000, which means there are significant differences between groups. Spearman-Kendall's correlation show that relationship between CRP and periodontal index p=0.000 with a correlation coefficient 0.875 means p<0.05 there was that a significant relationship exists between them and the relationship is strong . In relation OH and periodontitis index p=0.030 with a correlation coefficient of 0.650 means p<0.05 there was that a significant relationship exists between them and the relationship strong . Conclusion: It can be concluded that CRP levels in patients type 2 diabetes with periodontitis is higher than the patients type 2 diabetes without periodontitis. And there is a strong relationship between levels of CRP with periodontitis index , and also a strong relationship between periodontitis and OH index .
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Karteva, Teodora, and Neshka Manchorova-Veleva. "The Role of the Immune Response in Chronic Marginal and Apical Periodontitis." Folia Medica 62, no. 2 (June 30, 2020): 238–43. http://dx.doi.org/10.3897/folmed.62.e39599.
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The immune response is a complex, dynamic and strongly individual biologic network that plays an essential role in the pathogenesis of chronic apical and marginal periodontitis. Recent research in the field of periodontology has indicated that the major determinant of susceptibility to disease is the nature of the immunoinflammatory response as marginal periodontal tissue damage is thought to be primarily mediated by the host reaction. Whether the same rules apply for the development of apical periodontitis, however, remains largely unexplored. This review aims to draw parallels between the pathogenesis of chronic periodontitis of endodontic and marginal origin, outline the evidence for the destructive role of immune response in chronic marginal periodontitis and raise questions about its role in chronic apical periodontitis. It would be worthy to further explore the impact of the immune system on the characteristics and progress of these diseases and transfer some of the scientific models from the field of periodontology to the field of endodontics. Research in this area could lead to a more comprehensive understanding of the dynamics of apical and marginal periodontitis and lay the foundation of new personalized treatment strategies.
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Xu, Jing, Xin Chang, Huixin Zhang, Mengying Si, Huiying Su, Lilan Cao, Yingying Li, and Yuankun Zhai. "Exosomes: A bridge of periodontitis and systemic diseases." Gene & Protein in Disease 1, no. 2 (August 4, 2022): 99. http://dx.doi.org/10.36922/gpd.v1i2.99.
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Periodontitis, a common oral disease, is featured with complex etiology, progressive and prognosis varies according to the severity of periodontitis. Exosomes belong a kind of cystic vesicles with biological activity, which widely exist in human body fluids. Exosomes play an irreparable role in signal transmission and material exchange between cells, maintaining cell functions, and regulating body immunity and homeostasis. Exosomes are closely related to periodontitis, and recent study of exosomes has provided new directions and ideas for the diagnosis and treatment of periodontitis. Similarly, as extracellular vesicles, exosomes play a bridging role between periodontitis and some systemic diseases. In this process, exosomes participate in and regulate the process of systemic diseases by carrying nucleic acids, proteins, lipids, etc., and exhibit different bioactive effects according to the different substances carried in exosomes. In this paper, we summarize the latest research progress of exosomes, especially in the periodontitis and some systemic diseases, and review the potential value of exosomes in periodontitis diagnosis and treatments.
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Devanoorkar, Archana, Rahul Kathariya, Nagappa Guttiganur, D. Gopalakrishnan, and Paulami Bagchi. "Resistin: A Potential Biomarker for Periodontitis Influenced Diabetes Mellitus and Diabetes Induced Periodontitis." Disease Markers 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/930206.
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Biomarkers are highly specific and sensitive indicators of disease activity. Resistin is a recently discovered adipocytokine, having a potent biomarker quality. Initially resistin was thought to be produced by adipocytes alone; however, emerging evidence suggests that it is also produced in abundance by various cells of the immunoinflammatory system, indicating its role in various chronic inflammatory diseases. Data suggests that resistin plays a role in obesity, insulin resistance, cardiovascular diseases, and periodontitis. Resistin derived its name from the original observation that it induced insulin resistance (resist-in: resist insulin) in mice and is downregulated in mature murine adipocytes cultured in the presence of insulin sensitizing drugs like thiazolidinediones. It is well recognized that obesity, is associated with insulin resistance and diabetes. A three-way relationship has been established between diabetes, obesity and periodontitis. Recent evidence also suggests an association between obesity and increased risk for periodontitis. Our previous research showed incremental elevation of resistin with periodontal disease activity and a reduced level of resistin, after periodontal therapy. Thus resistin would be one of the molecular links connecting obesity, periodontitis, and diabetes and may serve as a marker that links periodontal disease with other systemic diseases. A Medline/PubMed search was carried out for keywords “Diabetes Mellitus,” “Periodontitis,” and “Resistin,” and all relevant research papers from 1990 in English were shortlisted and finalized based on their importance. This review provides an insight into the biological action of resistin and its possible role in periodontitis influenced diabetes mellitus and diabetes induced periodontitis.
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Pusporini, Ratih, Ahmad Basori, and Agung Krismariono. "The Effect of Papaya Seed Ethanol Extract in Vivo on The Number of Osteoblasts Cells of Periodontitis-Induced Rats." Majalah Obat Tradisional 24, no. 1 (April 30, 2019): 16. http://dx.doi.org/10.22146/mot.38492.
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The papaya seed ethanol extract is rich in antioxidant ingredients, such as flavonoids and phenolic acids. One of the main factors causing chronic inflammatory in periodontitis is oxidative stress. Administration of papaya seed extract is assumed to increase the number of rat osteoblast cells induced periodontitis. This research was conducted to analyze the effect of papaya seed extract on osteoblasts cells of rat induced periodontitis. This research represented an experimental laboratory-based investigation involving 35 rats of the Rattus norvegicus strain divided into 5 treatment groups (K, P1, P2, P3, P4). Control group (K) was not induced by periodontitis and was not given an extract, while group P induced periodontitis using LPS Phorphyromonas gingivalis (P.gingivalis) for 7 days and continued wire mesh installation around the mandibular incisors in the form of number “8” for 7 days. P1 group was given feed only without extract, while the rest were given extract of 200 mg/kgBB, 300mg/kgBB, and 400mg/kgBB. The data obtained were analyzed with a one-way ANOVA test. The results showed that the average number of osteoblasts varied significantly between the groups. There was an increase in the average number of osteoblast cells in rat induced periodontitis after given papaya seed extract.
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C, Chaya, and Suja K. sreedhar. "A LONGITUDINAL OBSERVATIONAL STUDY ON THE EFFECT OF GAURASARSAPA LEPANA AND LAKSHADI TAILA GANDUSHA IN DIABETIC PERIODONTITIS." International Ayurvedic Medical Journal 9, no. 8 (August 15, 2021): 1629–36. http://dx.doi.org/10.46607/iamj0509082021.
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Diabetes and Periodontitis are the most common chronic disease in the world. Abundant epidemiology evidence implies a bidirectional relationship between these two diseases. Periodontitis has been reported as the 6th compli- cation of Diabetic Mellitus. In Ayurveda, there is no direct reference for Diabetic Periodontitis. But the symptoms of Upakusha can be correlated to Periodontitis. Dantamala is one of the Prameha Poorvarupa which is quoted by Sushruta in NidanaSthana. Prathisarana and Gandusha are the procedures explained in our classics for oral hy- giene. So, the present study was undertaken to study the effect of Gaurasarsapa Lepana and LakshadiTaila Gandusha in the management of Diabetic Periodontitis. 40 patients with Diabetic Periodontitis as per inclusion criteria were selected from O.P.D and IPD of SJIIM Hospital, Bengaluru.40 Patients were treated by Gaurasarsa- pa Lepana followed by LakshadiTaila Gandusha for 15dyas. Clinical signs and symptoms were given suitable scores according to the severity and were assessed by pre and post data given in research proforma, designed for the study. The treatment showed significant results after the treatment. Keywords: Diabetic Periodontitis, Upakusha, Prathisarana, Gandusha.
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Ramadhanty, Aina, Didit Aspriyanto, and Beta Widya Oktiani. "THE EFFECTS OF PANORAMIC RADIOGRAPHY ONGINGIVAL CREVICULAR FLUIDVOLUME IN WISTAR RATS WITH PERIODONTITIS." Dentino : Jurnal Kedokteran Gigi 6, no. 1 (May 11, 2021): 1. http://dx.doi.org/10.20527/dentino.v6i1.10632.
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ABSTRACTBackground: Panoramic radiography is one of the most commonly used radiographic diagnostic tools. Panoramic radiography exposure can increase the GCF flow because of increasing vascular permeability.GCF flow can also increase in periodontitis conditions. Objective: The purpose of this study was to analyze the effects of 1, 2, and 3 times exposure of panoramic radiography to the volume of GCF in wistar rats with periodontitis. Method: This research was true experimental with post test onlycontrol group design. Thesampling technique used simple random samplingthat obtained 25 wistar rats comprising of 5 wistars from each group in which the GCF samples of each group was collected from. Results: The average number of GCF inhealthy rats groupthat was not exposed to panoramic radiographywas 0.114 µL, the periodontitis rats group that was not exposed to panoramic radiography was 0.246 µL, the periodontitis rats group that was exposed1 time was 0.286 µL, the group of periodontitis rats exposed 2 times was 0.294 µL, and periodontitis group of rats exposed 3 times was 0.374 µL. The results of the One-Way Anova and Post Hoc Bonferroni tests stated that there is a significant increase in the volume of GCF between the control group and all other treatment groups, as well as between the non-exposed periodontitis group and the periodontitis group with 3 times exposure. Conclusion: Panoramic radiography can causeincrease the volume of GCF in wistar rats with periodontitis. Keywords: Gingival Crevicular Fluid,panoramic, periodontitis, wistar rats
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Pejčić, Ana, Radmila Obradović, Marija Bradić-Vasić, Ivan Minić, and Džemil Kurtagić. "Periodontal health and detection of periodontal bacteria in patients with acute coronary syndrome." Acta stomatologica Naissi 36, no. 82 (2020): 2079–90. http://dx.doi.org/10.5937/asn2082079p.
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Introduction: Recent studies have found that patients with periodontitis have greater risk of incurring fatal cardiovascular disease than patients without periodontitis. Emerging research has identified inflammation caused by periodontitis as significantly increasing the risk for ACS. Aim: The aim of this study was to investigate a periodontal status in the patients with ACS, and to assess the association of different periodontal parameters with ACS. Material and methods: In the first group, patients both with ACS and periodontitis were enrolled as cases. Patients were examined 3 days after ischemia. The second group consisted of patients who had only periodontitis. The control group consisted of healthy individuals. Periodontal parameters were measured and matched on the basis of demographic characteristics and assessed between the groups. The severity of periodontitis in both cases was analyzed. Results: Analysis of the periodontal parameters showed that median scores were higher in patients in the first and the second group compared to the third control group but significantly higher in group with ACS. Levels of inflammatory markers were highest in the first group, compared to the second group and the control group. Periodontal pathogens were more strongly present in patients with ACS than in the group with periodontitis, indicating that it was a serious illness in these patients. Conclusion: This study supports an association between periodontitis and ACS. Severe periodontitis is present in this patients indicating that periodontitis can further act on the development of ACS.
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Machado, Vanessa, Joana Lopes, Mariana Patrão, João Botelho, Luís Proença, and José João Mendes. "Validity of the association between periodontitis and female infertility conditions: a concise review." Reproduction 160, no. 3 (September 2020): R41—R54. http://dx.doi.org/10.1530/rep-20-0176.
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Hormones and inflammatory mechanisms are implicated with female reproductive function, including follicle maturation, ovulation, embryo implantation, and pregnancy. Periodontitis is a chronic inflammatory disease due to a polymicrobial disruption of the homeostasis and may be considered as a potential risk factor that affect female fertility. The role of periodontitis is becoming meaningful, with significant associations with polycystic ovary syndrome, endometriosis and bacterial vaginosis. Further, periodontitis is linked with known risk factors towards female infertility, such as age, obesity, and chronic kidney disease. This review aims to summarize the available evidence on the association between periodontitis and female infertility-associated conditions, and to discuss warranting steps in future research.
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Giacon, Tommaso Antonio, Franco Giancola, Matteo Paganini, Cesare Tiengo, Enrico M. Camporesi, and Gerardo Bosco. "Hyperbaric Oxygen Therapy and A-PRF Pre-Treated Implants in Severe Periodontitis: A Case Report." International Journal of Environmental Research and Public Health 18, no. 2 (January 7, 2021): 413. http://dx.doi.org/10.3390/ijerph18020413.
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Implantation is currently the best option for tooth replacement in periodontitis. Some major contraindications for the immediate implant are acute periodontitis and active infection. We present the case of a 51-year-old female patient with the highest grade and stage periodontitis treated with advanced platelet-rich fibrin-enriched zirconia implants and with hyperbaric oxygen therapy (HBOT). In particular, HBOT before and after implantation promoted bone regeneration and implant integration, also providing an antiseptic effect. After six months, the implants were well established and fully healed from periodontal disease within 14 months. Further research could confirm a new indication for HBOT in treating periodontitis and dental implantation.
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Sari, Rezmelia, Prayitno Prayitno, and Alya Nur Fadhilah. "SNP G-1082A IL-10 GENE: ALLELE AND GENOTYPE DISTRIBUTION OF PERIODONTITIS PATIENT IN YOGYAKARTA." Dentika Dental Journal 19, no. 2 (December 12, 2016): 117–20. http://dx.doi.org/10.32734/dentika.v19i2.412.
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Periodontitis is multifactorial inflamation process and related to disproportion of cytokine. IL-10 is a dominant noninflammatory cytokines that related to gene polymorphism. Polymorphism G-1082A IL-10 genes has been reported to increase the risk of periodontitis occurs in Italian populations, apart from different result found in Brazilian. The purpose of this research was to determine the polymorphism G-1082A IL-10 in periodontitis patients in Indonesia, especially among Yogyakarta’s Javanese. This is a case-control research with subjects according to the inclusion criteria. DNA was taken by cotton swab from the epithelial cells of buccal mucosa, and was isolated using a PrestoTM (GeneAid) kit. Genotyping analysis by using the PCR RFLP technique and descriptive results were presented. The result showed that A allele frequency is 100% and no G allele was found. AA genotype in case group has lower frequency than in control group and vice versa. From this research, it was concluded that A allele was dominant in Yogyakarta’s Javanese, and AA genotype frequency is lower in individual with periodontitis.
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Gualpa Bustamante, Karen Priscila, María del Rocio Álvarez Calle, and Andrea Soledad Carvajal Endara. "Efecto del tratamiento periodontal no quirúrgico en el control de la artritis reumatoide." Research, Society and Development 11, no. 11 (August 15, 2022): e45111133148. http://dx.doi.org/10.33448/rsd-v11i11.33148.
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La periodontitis es una patología inflamatoria crónica no transmisible de etiología microbiana, que resulta en pérdida de la inserción periodontal. La artritis reumatoide -AR- es una enfermedad autoinmune sistémica crónica. La periodontitis y la AR comparten respuestas inmunes humorales y celulares similares y un perfil inmunogénico común; ambas afecciones pueden influir de manera bidireccional en la carga sistémica de la inflamación. El tratamiento periodontal no quirúrgico -TPNQ- de la periodontitis puede tener efectos beneficiosos sobre la actividad de la enfermedad de la AR. Objetivo: identificar la evidencia científica disponible sobre el impacto del TPNQ de la periodontitis sobre el control de la actividad de la enfermedad de la AR. Metodología: revisión narrativa de la literatura; se seleccionaron 10 publicaciones en inglés -desde 2009 hasta 2021-, de las bases de datos científicas PUBMED, COCHRANE y WILEY; se identificó información del impacto de la TPNQ de la periodontitis en pacientes con AR; los resultados se expresaron en texto y una tabla resumen. Resultados: el TPNQ de la periodontitis tuvo un impacto sobre la disminución de la actividad de la enfermedad de la AR. El índice de actividad de la enfermedad más usado en el paciente con AR, fue el DAS28. El TPNQ mejoró los parámetros clínicos de la periodontitis. Por todo esto, es necesaria la atención odontológica y el tratamiento periodontal en el manejo multidisciplinario del paciente con AR.
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Ramírez, Valeria, Maria Hach, and Rodrigo López. "Definition of aggressive periodontitis in periodontal research. A systematic review." Journal of Clinical Periodontology 45, no. 3 (January 19, 2018): 278–84. http://dx.doi.org/10.1111/jcpe.12853.
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Cotti, E., and G. Mercuro. "Apical periodontitis and cardiovascular diseases: previous findings and ongoing research." International Endodontic Journal 48, no. 10 (August 6, 2015): 926–32. http://dx.doi.org/10.1111/iej.12506.
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Kasuma, Nila. "The RELATION OF NEUTROPHIL ELASTASE LEVEL WITH TISSUE DESTRUCTION IN GINGIVITIS AND PERIODONTITIS." Dentika Dental Journal 20, no. 2 (December 1, 2017): 66–71. http://dx.doi.org/10.32734/dentika.v20i2.160.
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Periodontal disease consists of gingivitis and periodontitis. They occur due to the interaction between bacterial antigens and the host tissue hence neutrophil is activated, antibody is produced and bone resorption is occurred. Enzymatic changes to diagnose periodontal disease index (PDI) based on biomarker measurement scale is useful for an accurate diagnosis and a successful measurement of periodontal disease therapy. Gingival crevicular fluid (GCF) was selected as the biological medium. This research aims to analyze the relationship between neutrophil elastase level and periodontal tissue damages at gingivitis and periodontitis. The study involved 66 people as samples with 22 healthy samples, 22 mild gingivitis samples and 22 early periodontitis samples. Enzyme level studied was tested using ELISA technique. In this cross-sectional study, neutrophil elastase enzyme level was compared between healthy, mild gingivitis and early periodontitis sample groups. Data analysis was performed using ANOVA test. The average NE level based on PDI group is ± SD 2.65 ng/dl ± 1.28 in healthy sample group. There is an increase by 2.3 times in mild gingivitis sample group where NE level is ± SD 6.27 ng/dl ± 1.13.While, the light periodontitis group has NE level of ± SD 9.38 ng/dl ± 1.06 which equals to 3.5 times increase from the healthy sample group. This research concludes that the rise of neutrophil elastase level in gingival crevicular fluid is related to the severity of gingivitis and periodontitis diseases.
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Syaify, Ahmad, Sri Budi Barunawati, Suryono Suryono, and Marsetyawan HNES. "Expression of MRP8/MRP14 mRNA in Monocytes of Periodontitis: Comparison between Diabetic and Non Diabetic Patients." Indonesian Journal of Dental Research 1, no. 1 (January 14, 2010): 39. http://dx.doi.org/10.22146/theindjdentres.9986.
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The severity of periodontitis on patients with type 2 Diabetes Mellitus patients was strongly thought caused by decreasing of leukocytes function such as monoctyes and neutrophils. In our previous research it was found that calprotectin (MRP8/MRP14) level in leukocytes of periodontitis patients with type 2 DM was higher than periodontitis in non DM. The aim of this study was to determine calprotectin (MRP8/MRP14)mRNA expression in human monocytes of periodontitis patients with type 2 DM and without DM. Monocytes were isolated from the peripheral blood of periodontitis patients with uncontrolled type 2 DM, controlled type 2 DM, and non DM. The expression of total RNA calprotectin (MRP8 and MRP14) were detected by RTPCR using GAPDH as the innate control. It was observed that the value of MRP8/MRP14 mRNA expression DM patients were higher than non DM, and the highly significant increase expression (p<0.05) was on the uncontrolled type 2 DM. The basal level of MRP8/MRP14 expression increased in monocyte of periodontitis and type 2 DM patients compared with non diabetes subjects. It was suggested that high basal level MRP8/MRP14 has role in the regulation of severity periodontitis with diabetes mellitus.
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Kdkhodazadeh, Mahdi, Mehrdad Hajilooi, Behzad Houshmand, Sara Khazaei, Leila Gholami, and Sara Alijani. "Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals." ISRN Dentistry 2012 (March 5, 2012): 1–5. http://dx.doi.org/10.5402/2012/751920.
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Objective. Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis. Methods. Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy individuals. Samples were genotyped and analyzed for the three single-nucleotide polymorphisms (SNPs) of PECAM-1 using polymerase chain reaction with sequence-specific primers (PCR-SSPs). Results. A statistically significant difference was found between the genotypic distribution of the Ser563Asn polymorphism in patients with periodontitis compared to controls (P=0.02). But there were no statistically significant difference between the allele frequencies in the different groups (P=0.05). The other two polymorphisms did not show a statistically significant difference in their allele and genotype frequencies between the groups. There was no statistically significant difference found for any of the polymorphisms allele and genotype distribution in aggressive and chronic periodontitis either. Conclusions. No significant association was found between the polymorphism tested and the subgroups of periodontitis, further research is still necessary to determine whether this polymorphism can be used as a genetic marker of periodontitis.
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CHANAL, Izzati Chatyarianti, Agus SUSANTO, and Ira KOMARA. "Association between severity of periodontitis and rheumatoid arthritis." Journal of Syiah Kuala Dentistry Society 6, no. 2 (January 4, 2022): 113–21. http://dx.doi.org/10.24815/jds.v6i2.24192.
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ABSTRACT Many studies have shown a correlation between periodontitis and rheumatoid arthritis, and both areinflammatory diseases that cause damage to their surrounding tissues and have similar characteristics. Periodontitiscan cause an increased erythrocyte sedimentation rate and C-reactive protein in rheumatoid arthritis (RA) patientsand can cause systemic inflammation in RA. This review aims to assess the association between the severity ofperiodontitis and rheumatoid arthritis. The method of this study is scoping review. PRISMA method is used as aguideline for searching and selecting articles using four electronic databases with criteria (P: Population)periodontitis and rheumatoid arthritis patients, (C: Concept) Relationship between periodontitis and rheumatoidarthritis, (C: Context) periodontal medicine. Articles selection based on the inclusion criteria: journals published in2011-2020, research methods using case-control, cohort, or RCT, subjects diagnosed with RA and Periodontitis, andsubjects age at least 18 years old and exclusion criteria are subjects were pregnant and issues diagnosed with otherdiseases. Six articles included one cohort study and five case-control studies. The result showed a positivecorrelation between periodontitis and RA. There is an association between the severity of periodontitis andrheumatoid arthritisKEYWORDS: Periodontitis, periodontal disease, rheumatoid arthritis
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Takashiba, Shogo. "Overview of the research work of Prof. Takashiba and the Department of Pathophysiology – Periodontal Science – research outputs and impact." Impact 2021, no. 6 (July 15, 2021): 34–36. http://dx.doi.org/10.21820/23987073.2021.6.34.
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If periodontitis, or gum disease, is left untreated, it can lead to strokes, diabetes, heart disease and the onset of dementia. The alveolar bone is an area of the mouth that is particularly impacted by periodontal disease and periodontists have therefore been searching for a means of regenerating lost alveolar bone with periodontal tissue. Dr Shogo Takashiba, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences at Okayama University, is working to help patients retain the oral functions they require for nutrition and to develop means of managing infection and inflammation, thereby improving general health. In particular, he and his team are looking at preventing biofilm-related infection, evaluating infection and inflammation, and regenerating periodontal tissue. A key focus for the researchers is on producing cost-effective methods for treating periodontal disease and, as such, they are working to develop anti-biofilm reagents for long-term use considering emerging issue of antimicrobial resistance. Part of this work involves cetylpyridinium chloride hydrate (CPC) and Takashiba and the team have developed a strategy to prevent the development of biofilm by combining phosphorylated pullulan and CPC. They have obtained patents for their oral wash, rinse and ointments in Japan, China, the US, the EU and Canada and are now looking at how to produce these regenerative and anti-biofilm treatments on an industrial scale, which will enable the general public to access the innovative treatments.
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Babaloo, Amir Reza, Adileh Shirmohammadi, Siamak Sandoghchian shotorbani, Ashkan Kamalzadeh, and Shima Ghasemi. "Evaluation of the effect of IL-36γ expression on chronic periodontitis by enhancing the MAPK and TLR4 signaling pathways: A basic research." Journal of Dental Research, Dental Clinics, Dental Prospects 12, no. 3 (September 26, 2018): 159–65. http://dx.doi.org/10.15171/joddd.2018.025.
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Background. Periodontitis is an infectious and inflammatory disease of the supporting tissues of the tooth caused by specific microorganisms or a group of microorganisms and, if not treated, leads to progressive degradation of the supporting tissues and subsequent loss of the teeth affected. The aim of this study was to evaluate the effects of IL-36γ on periodontitis by enhancing the TLR4 and MAPK signaling pathways. Methods. In this pilot study, 50 patients with generalized moderate-to-severe chronic periodontitis and 50 individuals with healthy periodontium, who were candidates for crown lengthening (CL), were selected based on inclusion criteria. The tissue samples were taken during pocket depth surgery (for the test group) and CL surgery (for the control group). The macrophage cells of the inflammatory tissues were extracted and stimulated by TLR4 proteins in a time-dependent manner; then IL-36γ levels in macrophages were investigated. Data were analyzed using descriptive statistics (means ± standard deviations and frequency percentages). Repeat measurement test was used to compare IL36γ expression in MAPK and TLR4 pathways at different time intervals. ANCOVA was used to compare IL36γ expression at different time intervals between the two pathways. Statistical analysis was performed using SPSS 17 at a significance level of P<0.05. Results. The results of the current study showed a significant relation between TLR4 and IL-36γ (P<0.001); in tissues with generalized moderate-to-severe chronic periodontitis, there was a significant relation between the condition and IL-36γ (P<0.0001). This study also showed that TLR4 and MAPK levels increased in the presence of IL-36γ. Conclusion. According to the present study, it was concluded that IL-36γ concentrations increased in periodontitis, which could trigger MAPK and TLR4 pathways.
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Isola, Gaetano. "Antibiotics and Antimicrobials for Treatment of the Oral Microbiota: Myths and Facts in Research and Clinical Practice." Antibiotics 9, no. 2 (February 22, 2020): 95. http://dx.doi.org/10.3390/antibiotics9020095.
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In the dental field, the most common oral diseases include periodontitis, apical periodontitis, abscesses, phlegmons and pulpits, all of which are determined by the same aetiological factor, bacterial infections. For these reasons, it is important to choose the right approach through a target antibiotic therapy against oral bacteria. More specifically, during periodontitis, antibiotics are used, often in association with periodontal debridement, to reduce disease-associated periodontopathogens. However, international guidelines are not unanimous in recommending the use of local and/or systemic antimicrobials to reduce infection by oral bacteria, especially in cases in which there is a danger of spreading systemic infection such as cellulitis, diffuse swelling, and abscesses. The lack of consensus is mainly due to the side effects of antibiotic therapy in dentistry, maybe due to recent scientific evidence regarding the development of bacterial resistance to antibiotics. Therefore, the purpose of this editorial is to analyze the therapeutic effects of antibiotics against the main forms of oral and periodontal diseases, and whether there is a significant clinical benefit, especially in the long term, of antimicrobial therapies in dentistry. The most recent evidence regarding antimicrobial agents will also be discussed.
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Silenko, G. M., O. B. Belikov, N. I. Belikova, M. V. Khrebor, and Y. I. Silenko. "THE INFLUENCE OF A POLYPEPTIDE PREPARATION ON A STRUCTURAL-FUNCTIONAL STATE PERIODONT IN ADJURANT PERIODONITIS (EXPERIMENTAL RESEARCH)." Ukrainian Dental Almanac, no. 2 (June 26, 2020): 29–34. http://dx.doi.org/10.31718/2409-0255.2.2020.04.
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The aim of this article is to study the indices of cellular, humoral immunity and nonspecific resistance, indices of free radical lipid oxidation and thrombocytoactive properties of periodontal tissues in animals with adjuvant periodontitis.
In our study, adjuvant periodontitis was reproduced by the method of A.M. Kaminsky, immunizing rats with a homologous periodontal tissue in admixture with a Freund's adjuvant in a 1: 1 ratio. The course consisted of four single injections of 0.2 ml per animal intramuscularly at weekly intervals. Immunization did not lead to changes in the development and behavior of rats. One month after immunization, experimental animals experienced symptoms characteristic of generalized periodontitis in humans. They were manifested in the form of gums, resorption of alveolar bone, mobility and tooth loss.
The induction of adjuvant periodontitis in experimental animals led to a significant increase in lipid peroxidation processes in periodontal tissues and a decrease in SOD and catalase activity. In animals with adjuvant periodontitis, which have been injected with periodontal polypeptides, there is a decrease in the reactions of GF compared with patients. In particular, there was a 40.9% decrease in the level of TBK-active products, although the level of MDA accumulation in the incubation process had not decreased significantly. It is noteworthy that in this group of animals increased activity of AO enzymes, which in patients was sharply reduced.
Significant changes in the BPO lipid state were also observed in the blood of animals. The peroxidation reactions were significantly reduced, but not as significantly as in periodontal tissues. In particular, spontaneous erythrocyte hemolysis was lower by 14.2%, the level of TBK-active products by 39.4%, and MDA by 34.9%. An increase in the activity of SOD and catalase was observed, as well as a 40.4% decrease in the concentration of ceruloplasmin, which testifies to the elimination of the inflammatory response upon introduction of polypeptides.
The treatment of animals with periodontylline was accompanied by an increase in the anti-aggregation properties of periodontal tissues. This is confirmed by the following indicators of the aggregate: the angle of aggregation is reduced by 31.8%, the optical density by 29%, the aggregation time is increased by 42.9% compared with the group of animals with adjuvant periodontitis.
The introduction of parodontilin had a pronounced effect on the condition of blood clotting and fibrinolysis. We observed a significant increase in recalcification time, thrombin, prothrombin time. If the disease has a significant increase in the time of euglobulin fibrinolysis, then in the treatment of this indicator becomes less by 69.4%, the products of para-coagulation disappear from the bloodstream and the concentration of fibrin degradation products decreases.
The treatment of animals was accompanied by an increase in immunity, which was manifested by an increase in T and B lymphocytes and Ig G. titer.
Studies have shown that the treatment of diseased animals with a polypeptide drug leads to an improvement in the cellular, humoral immunity and nonspecific resistance of the organism, as well as the presence of a pronounced immunomodulatory effect of periodontin. The previously established relationship between blood clotting systems, sex, immunity, nonspecific resistance of the organism is confirmed in these experimental studies. If the induction of periodontitis is primarily associated with autoimmune processes, leading to impaired homeostasis, then the introduction of periodontin has a modulating effect on both immunity and indicators of lipid peroxidation and microcirculatory and coagulative hemostasis . In animals, regression of dental symptoms was noted, signs of periodontal inflammation, bleeding, swelling disappeared, and tooth mobility decreased.
These data indicate the high therapeutic efficacy of thymic drugs in the treatment of generalized periodontitis. Research in this area remains relevant.
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Wang, Hui, Lulu Wang, Tian Chao, and Zhonghui Kang. "Analysis of the Therapeutic Effect of Nano-Silver on Periodontitis and Its Influence on Disease Recurrence." Tobacco Regulatory Science 7, no. 5 (September 30, 2021): 1131–37. http://dx.doi.org/10.18001/trs.7.5.31.
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Periodontitis is a chronic oral inflammatory disease that is difficult to treat and is therefore the subject of clinical research seeking new and effective treatment. Nano-silver has antibacterial and anti-inflammatory effects; however, its application in periodontitis is not well studied. In this study, we show decreases in periodontitis-associated inflammatory cytokines interleukin IL-4, IL-6, IL-8, IL-10, and tumor necrosis factor alpha (TNF-a) (P < 0.05) and in oxidative stress (P < 0.05) under intervention with nano-silver solution. The protein expression of CCL21, heat-shock protein 90 (HSP90), andE-selectin in periodontal tissues decreased (P < 0.05), while bone structure improved (P < 0.05). This work suggests that nano-silver solution can effectively inhibit the inflammatory response and oxidative stress response of periodontitis and improve the periodontal tissue and tooth structure to some extent; it may provide a new periodontitis treatment in the future.
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Alshammari, Abdulsalam K. S., and Monika M. Wahi. "A Narrative Review of the Prevalence of Periodontitis in Saudi Arabia: A Proposal for a National Oral Health Research Agenda for Vision 2030." Open Dentistry Journal 13, no. 1 (April 30, 2019): 171–76. http://dx.doi.org/10.2174/1874210601913010171.
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Objective:The objective of this narrative review is to summarize the current knowledge on the prevalence of periodontitis in the Kingdom of Saudi Arabia (KSA) and to make recommendations for monitoring and improving oral health in the KSA population.Background:Periodontitis is a significant health issue in the general population, so conducting routine public health surveillance for this condition is important in every country. KSA is currently implementing a strategic plan called Vision 2030 which aims to improve many of the country’s infrastructures, including healthcare.Methods:To conduct this narrative review, Google Scholar (GS) was used to search for peer-reviewed articles on the prevalence of periodontitis in KSA. No limits were placed on the year of publication, but only articles translated into English were considered. Search terms used included “Saudi Arabia”, “periodontitis”, “surveillance”, “prevalence”, “rates”, “oral health” and “dental”.Results:The earliest estimate identified was from 1992, in which the rate of lack of periodontal health was estimated to be 90% in KSA residents aged 25 and over. A more recent estimate reported rates around 50%, but used a different case definition. Studies on tobacco use, periodontal health and KSA established that how tobacco is used strongly influences periodontal status. Other dental studies in KSA focus on other topics. The Saudi Health Information Survey (SHIS) conducted in 2013 asked oral health questions, but did not seek to estimate the rates of periodontitis in KSA.Conclusion:The World Health Organization’s (WHO) recommendations suggest that KSA should conduct research to develop surveillance case definitions of periodontitis that will have specific utility in KSA, and can be standardized to compare KSA rates with the rates worldwide. The existing surveillance definitions and efforts in other countries have been considered less than optimal, so research is needed to inform KSA’s effort. Recommendations are made for a national oral health research agenda in KSA under Vision 2030.
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Schmidt, Pavlo, and Anatoliy Gulyuk. "CHANGES IN SOME PERIPHERAL BLOOD IMMUNE PARAMETERS OF PATIENTS WITH CHRONIC PERIODONTITIS AMONG SERVICEMEN OF THE ARMED FORCES OF UKRAINE." ScienceRise, no. 5 (October 31, 2020): 54–60. http://dx.doi.org/10.21303/2313-8416.2020.001461.
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The object of research: the state of chronic periodontitis among servicemen of the Armed Forces of Ukraine remains extremely urgent. Therefore a group of servicemen with chronic periodontitis and its complications was taken. In addition, a control group of servicemen was used to compare the results.
Investigated problem: in this article, the diagnosis was considered due to the use of immunological studies of peripheral blood of sick servicemen of the Armed Forces of Ukraine with chronic periodontitis, as well as its complications. The study of the features of immunological parameters in peripheral blood was performed.
The main scientific results: according to the obtained data, there is a relative suppression of immunity among servicemen with chronic periapical infection compared with servicemen of the control group.
According to our data, the main lymphocyte subpopulation of peripheral blood are CD8 and CD4 / CD8; CD19+(B-lymphocytes) and CD3-HLA+; CD4 and CD4 / CD8, which reflect inflammatory processes in the body. These indicators are closely interrelated.
The area of practical use of the research results: these results of research can be applied to students’ training at stomatology faculties, in stomatology practice, to research into the immunological status of patients with chronic periodontitis and its complications.
Innovative technological product: it is the first time the study of the immunological status of peripheral blood during chronic periapical infections among servicemen has been performed.
Scope of the innovative technological product: this study can be used in the diagnosis and treatment of chronic periodontitis in dental practice, as well as in the research to compare the results of the immunological state of peripheral blood.
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R, Retno Indrawati, Indeswati Diyatri, and Dwi Rahmawati. "The Effectiveness of Antibiotics and Hematopoietic Stem Cell Treatment in Periodontitis Rat Model Toward TNF α Expression." KnE Life Sciences 3, no. 6 (December 3, 2017): 513. http://dx.doi.org/10.18502/kls.v3i6.1176.
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Periodontitis is a biofilm-induced chronic inflammatory. The current therapy of periodontitis is scaling root planning and curettage, and followed by administration of antibiotic such as combination of Amoxicillin and Clavulanic acid. Hematopoietic Stem Cell has ability to differentiate into blood cells which is capable of homing and regenerating itself. Research Purpose: The aim of this study was to prove antibiotic and Hematopoietic Stem Cell administration can reduce TNF α expression. Method: This research was divided into four different groups, P1 as negative control group, P2 as positive control group which inoculated with P.gingivalis 109 for three weeks as chronic periodontitis rat model and USP were administered, P3 as chronic periodontitis rat model received Hematopoietic Stem Cell injection into the tail vein of rat, P4 as chronic periodontitis rat models were given Amoxicillin and Clavulanic acid 250 mg/kg BW orally then followed by Hematopoietic Stem Cell 106 injection into the tail vein of rat. After two weeks rat were sacrified and immunohistochemically analysed for expression of TNF α. The data were analysed by using Non-Parametric Test. Result: TNF α expression of negative control group was different as compared to positive control group and treatment group which given Hematopoietic Stem Cell injection, but there is no difference between negative control group with treatment group which given Amoxicillin and Clavulanic acid 250 mg/kg BW orally and followed by Hematopoietic Stem Cell injection. Clonclusion: The administration of Amoxicillin and Clavulanic acid 250 mg/kg BW and Hematopoietic Stem Cell can reduce TNF α expression on periodontitis rat model.Keyword: Hematopoetic Stem Cell, TNF α, Chronic Periodontitis, Antibiotic
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Missio, Alana Luiza Trenhago, Gerson Aparecido Foratori-Junior, Bruno Gualtieri Jesuino, Leonardo da Silva Máscoli, Nathália dos Santos Fusco, Rafaela Aparecida Caracho, Carla Andreotti Damante, and Silvia Helena de Carvalho Sales-Peres. "Periodontal disease during pregnancy: assessment of determinants of health and quality of life in pregnant women with periodontitis." Research, Society and Development 10, no. 10 (August 8, 2021): e204101018779. http://dx.doi.org/10.33448/rsd-v10i10.18779.
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Periodontitis in pregnancy may be associated with several determinants of health and knowing these determinants makes possible an integral approach of the patients. The aim of this study was to evaluate the determinants of health and periodontitis-related quality of life in pregnant women. Sample was composed by 128 patients divided into two groups: pregnant women with periodontitis (GP = 64) and without periodontitis (GWP = 64) during the third trimester of pregnancy. They were evaluated regarding: a) socioeconomic level; b) anthropometric parameters; c) systemic conditions - presence of arterial hypertension and diabetes mellitus; d) behaviors regarding oral hygiene; and e) oral health impact profile (OHIP-14). T-test, Mann-Whitney U-test, chi-square and logistic regression were applied, considering a significance level of 5%. GP showed low socioeconomic level (P = 0.0008), high maternal body mass index (BMI) (P = 0.0002) and excessive gestational weight gain (P = 0.008). No intergroup differences were observed in systemic conditions. Patients with periodontitis presented low daily dental floss use (P = 0.021) and strong impact on quality of life for all evaluated dimensions (P < 0.05). Periodontitis in pregnancy was associated with high BMI, excessive gestational weight gain, low socioeconomic level, poor oral hygiene behaviors and negative impact on quality of life.
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Baumeister, Sebastian-Edgar, Michael Nolde, Birte Holtfreter, Hansjörg Baurecht, Sven Gläser, Thomas Kocher, and Benjamin Ehmke. "Periodontitis and pulmonary function: a Mendelian randomization study." Clinical Oral Investigations 25, no. 8 (May 27, 2021): 5109–12. http://dx.doi.org/10.1007/s00784-021-04000-9.
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Abstract Objectives Observational research suggests that periodontitis affects pulmonary function; however, observational studies are subject to confounding and reverse causation, making causal inference and the direction of these associations difficult. We used Mendelian randomization (MR) to assess the potential causal association between genetic liability to periodontitis and pulmonary function. Materials and methods We used six single-nucleotide polymorphisms (SNPs) associated with periodontitis (P < 5 × 10−6) from a genome-wide association study (GWAS) of 17,353 European descent periodontitis cases and 28,210 controls from the GeneLifestyle Interactions in Dental Endpoints consortium and the UK Biobank, and related these to SNPs from a lung function GWAS including 79,055 study participants of the SpiroMeta Consortium. Results MR analysis suggested no effect of periodontitis on the ratio of forced expiratory volume in one second to lower forced vital capacity (standard deviation increment in outcome per doubling of the odds of the exposure (95% confidence interval) = − 0.004 (− 0.028; 0.020)). Replication analysis using genetic instruments from two different GWAS and sensitivity analyses to address potential pleiotropy led to no substantial changes in estimates. Conclusions Collectively, these findings do not support a relationship between genetic liability for periodontitis and pulmonary function. Clinical relevance Periodontitis does not seem to be a risk factor for worsening of pulmonary function.
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Han, Pingping, Peter Mark Bartold, Carlos Salomon, and Sašo Ivanovski. "Salivary Outer Membrane Vesicles and DNA Methylation of Small Extracellular Vesicles as Biomarkers for Periodontal Status: A Pilot Study." International Journal of Molecular Sciences 22, no. 5 (February 28, 2021): 2423. http://dx.doi.org/10.3390/ijms22052423.
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Periodontitis is an inflammatory disease, associated with a microbial dysbiosis. Early detection using salivary small extracellular vesicles (sEVs) biomarkers may facilitate timely prevention. sEVs derived from different species (i.e., humans, bacteria) are expected to circulate in saliva. This pilot study recruited 22 participants (seven periodontal healthy, seven gingivitis and eight periodontitis) and salivary sEVs were isolated using the size-exclusion chromatography (SEC) method. The healthy, gingivitis and periodontitis groups were compared in terms of salivary sEVs in the CD9+ sEV subpopulation, Gram-negative bacteria-enriched lipopolysaccharide (LPS+) outer membrane vesicles (OMVs) and global DNA methylation pattern of 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and N6-Methyladenosine (m6dA). It was found that LPS+ OMVs, global 5mC methylation and four periodontal pathogens (T. denticola, E. corrodens, P. gingivalis and F. nucleatum) that secreted OMVs were significantly increased in periodontitis sEVs compared to those from healthy groups. These differences were more pronounced in sEVs than the whole saliva and were more superior in distinguishing periodontitis than gingivitis, in comparison to healthy patients. Of note, global 5mC hypermethylation in salivary sEVs can distinguish periodontitis patients from both healthy controls and gingivitis patients with high sensitivity and specificity (AUC = 1). The research findings suggest that assessing global sEV methylation may be a useful biomarker for periodontitis.
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Wiguna, Stephanie, Risti Saptarini Primarti, and Iwan Ahmad Musnamirwan. "<p>Efektifitas quad-helix dalam perawatan defisiensi transversal maksila pada anak<p></p>Effectiveness of quad-helix for transverse maxillary deficiency treatment in children<p>." Jurnal Kedokteran Gigi Universitas Padjadjaran 33, no. 3 (December 27, 2021): 180. http://dx.doi.org/10.24198/jkg.v33i3.27967.
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Pendahuluan: Periodontitis apikalis adalah peradangan dan kerusakan jaringan pada daerah apikal jaringan periodonsium. Terjadi akibat pulpa nekrosis mengalami perluasan infeksi dari bakteri saluran akar menuju apeks gigi. Penelitian terdahulu membuktikan bahwa periodontitis apikalis dapat dikaitkan dengan peningkatan kadar interleukin-6. Interleukin-6 adalah salah satu sitokin pro-inflamatori yang mempunyai peran penting dalam respon inflamasi. Tujuan penelitian menganalisis perbedaan kadar interleukin-6 dalam darah vena antara pasien dengan periodontitis apikalis dan pasien tanpa periodontitis apikalis. Metode: Jenis penelitian observasional analitik dengan dua puluh sampel stok darah vena yang terdiri atas 10 sampel darah vena pasien dengan periodontitis apikalis dan 10 sampel darah vena pasien tanpa periodontitis apikalis. Serum darah yang telah dipisahkan dengan metode sentrifugasi dipakai sebagai sampel uji enzyme-linked immunosorbent assay (ELISA) sandwich untuk mengukur kadar IL-6 dengan membaca nilai absorbansi dan kurva standar. Data yang diperoleh dianalisis menggunakan uji Shapiro-Wilk, dilanjutkan dengan uji T tidak berpasangan. Hasil: Kadar IL-6 teridentifikasi pada semua sampel. Sampel darah vena pasien tanpa periodontitis apikalis memiliki kadar IL-6 berkisar antara 4,7-18,74 mg/L, sedangkan kadar IL-6 pada pasien dengan periodontitis apikalis 4,0-90,75 mg/L. Uji T tidak berpasangan menunjukan bahwa terdapat perbedaan yang bermakna (p=0.02). Simpulan: Kadar IL-6 pada darah vena dengan periodontitis apikalis lebih tinggi dibandingkan kadar IL-6 pada tanpa periodontitis apikalis.Kata kunci: periodontitis apikalis; interleukin-6; Enzim-Linked Immunosorbent Assay Sandwich ABSTRACT Introduction: Apical periodontitis is inflammation and tissue damage in the apical area of the periodontium. Occurs due to pulp necrosis experiencing an expansion of infection from root canal bacteria to the apex of the tooth. Previous studies have shown that apical periodontitis can be associated with elevated levels of interleukin-6. Interleukin-6 is a pro-inflammatory cytokine that has a vital role in the inflammatory response. The study aimed to analyze differences in interleukin-6 levels in venous blood between patients with apical periodontitis and patients without apical periodontitis. Methods: This research was an analytic observational study with twenty venous blood samples consisting of 10 venous blood samples from patients with apical periodontitis and ten venous blood samples from patients without apical periodontitis. Blood serum that has been separated by centrifugation method was used as a sandwich enzyme-linked immunosorbent assay (ELISA) test sample to measure IL-6 levels by reading absorbance values and standard curves. The data obtained were analyzed using the Shapiro-Wilk test, followed by an unpaired T-test. Results: IL-6 levels were identified in all samples. Venous blood samples from patients without apical periodontitis had IL-6 levels ranging from 4.7-18.74 mg/L, while IL-6 levels in patients with apical periodontitis were 4.0-90.75 mg/L. The unpaired t-test showed that there was a significant difference (p=0.02). Conclusion: IL-6 levels in venous blood with apical periodontitis were higher than IL-6 levels in those without apical periodontitis.Keywords: apical periodontitis; interleukin-6; Enzyme-Linked Immunosorbent Assay Sandwich
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Zoellner, Hans, and Neil Hunter. "Vascular expansion in chronic periodontitis." Journal of Oral Pathology and Medicine 20, no. 9 (October 1991): 433–37. http://dx.doi.org/10.1111/j.1600-0714.1991.tb00434.x.
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Jin, Fuqian, Jukun Song, Yi Luo, Beichuan Wang, Ming Ding, Jiaxin Hu, and Zhu Chen. "Association between skull bone mineral density and periodontitis: Using the National Health and Nutrition Examination Survey (2011–2014)." PLOS ONE 17, no. 12 (December 30, 2022): e0271475. http://dx.doi.org/10.1371/journal.pone.0271475.
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Background and objective Bone mineral density (BMD) and periodontitis have been the subject of many studies. However, the relationship between skull (including mandible) BMD and periodontitis has not been extensively studied. An objective of this cross-sectional study was to examine the relationship between skull BMD and periodontitis using data from the National Health and Nutrition Examination Surveys (NHANES) for 2011–2012 and 2013–2014. Materials and methods From NHANES 2011–2014, 3802 participants aged 30–59 were selected. We divided the skull BMD level into quartiles to check the distribution of variables. Periodontitis was defined by the Centers for Disease Control and Prevention (CDC) and the American Association of Periodontology (AAP) in 2012. Multivariate logical regression analysis was used to explore the independent relationship between skull BMD and periodontitis. The generalized additive model (GAM), smooth curve fitting (penalty spline) and threshold effect analysis was used to evaluate dose-response relationship between skull BMD and periodontitis and the potential nonlinear relationship between skull BMD and periodontitis. Finally, subgroup analysis and interaction test were conducted to determine the role of covariates between skull BMD and periodontitis. Results The overall average skull BMD of 3802 participants was 2.24g/cm2, the average age was 43.94 years, and the prevalence of periodontitis was 41.03%. In the fully adjusted logistic regression model, skull BMD and periodontitis showed an independent negative correlation (OR 0.73, 95% CI 0.59–0.90, P = 0.0032) and a linear relationship. Compared with the lowest quartile array (Q1:1.22–1.98) of skull BMD, the highest quartile array(Q4: 2.47–3.79) had a significantly lower risk of periodontitis (OR 0.70,95% CI 0.56–0.87, P = 0.0014). Subgroup analysis showed a highly consistent negative correlation between skull BMD and periodontitis. In the interaction test, people with moderate poverty income ratio (1.57–3.62) and those who had more than 12 alcohol drinks in the past year had a lower risk of periodontitis. Conclusions This result suggested that periodontal disease can be related to low skull BMD, for those people, oral hygiene and health care should be more closely monitored. Validation of our findings will require further research.
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Al Subait, Abeer Abdulrahman, Khadijah Mustafa Saidi, Hussain Hadi Alsagoor, Naif Mayouf Alrasheedi, Asma Gadan Alanazi, Redwan Jamalaldeen Alfattany, Hatim Marzouq Alshammari, et al. "Prevalence, incidence and outcome of periodontal diseases among the elderly." International Journal Of Community Medicine And Public Health 9, no. 1 (December 27, 2021): 409. http://dx.doi.org/10.18203/2394-6040.ijcmph20214835.
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When compared to adults, older persons have a higher prevalence and incidence of periodontal diseases. The prevalence of periodontitis is substantially greater in the geriatrics group, which is 75 years old on average, compared to those who are 60 years old on average. Periodontitis can lead to tooth loss if natural periodontal therapies are not used. Periodontitis is the sixth most frequent incurable illness in the world, characterized by bacterial-induced and host-mediated deterioration of both soft and hard structures around the teeth. A severe type of periodontitis affects around 10% of the world's population. Periodontitis is more frequent in adults because of its chronic and debilitating nature, with around 66% of the 65-year-old age group in the United States afflicted by chronic periodontitis. A critical component of a successful disease prevention and health promotion trajectory is having up-to-date information on demographics, clinical symptoms, and illness burden on individuals, particularly in underrepresented regions where preventive programs are targeted and executed. As a result, the purpose of this paper is to evaluate the existing research on the prevalence, incidence, and consequences of periodontal diseases in the older population.
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Karmakar, Shaswata, Ankita Kar, Shalini Thakur, and Vishal U. S. Rao. "Periodontitis and oral Cancer-A striking link." Oral Oncology 106 (July 2020): 104630. http://dx.doi.org/10.1016/j.oraloncology.2020.104630.
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Purnama, Ryana Budi, Setiadi Warata Logamarta, and Agung Dhartono. "POLYMORPHISM VITAMIN D RECEPTOR GENE (VDR) BSMI (RS1544410) CHRONIC PERIODONTITIS PATIENT IN JAVANESE BANYUMAS ETHNIC." Journal of Vocational Health Studies 4, no. 3 (March 31, 2021): 107. http://dx.doi.org/10.20473/jvhs.v4.i3.2021.107-113.
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Background: Chronic periodontitis, a chronic inflammatory condition of periodontal tissue, can occur due to microorganisms as a local factor and genetic as a systemic factor. Genetic factors that cause chronic periodontitis, namely mutations in the form of a gene that functions to regulate calcium homeostasis, which is called the vitamin D receptor (VDR) gene. Mutated VDR gene causing different effect in a population and ethnic groups, including Javanese Banyumas Ethnic. Purpose: To understand the genotype distribution and VDR BsmI (rs1544410) gene allotype frequency chronic periodontitis patient in Javanese Banyumas Ethnic. Method: The research was descriptive research in the form of a cross-sectional study of 26 chronic periodontitis patients in the Javanese Banyumas tribe. The samples obtained were carried out by the process of DNA isolation, Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP), and data in the Hardy-Weinberg Equilibrium (HWE) Court Lab analysis. Result: Whole samples from DNA isolation amplificated with one ribbon 524 bp VDR gene. RFLP restriction enzyme Bsml process is also showing cutting in each sample. From data analysis, X2 is 0,44 with p=0,50 (p>0,05) resulted. It was showing mutant VDR gene allele frequency in chronic periodontitis patients in Javanese Banyumas ethnic were balanced genetically. Conclusion: Genotype distribution in chronic periodontitis patient in Javanese Banyumas ethnic were 20 (76,9%) GG (bb) genotype, 6 (23,1%) GA (Bb) genotype, and 0 (0%) AA (BB) genotype with alel G (b) (wild type) allele frequency 0,88 (88%) and A allele (B or mutant) 0,12 (12%).