Journal articles on the topic 'Periodontitis Longitudinal studies'
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Leite, Fábio R. M., Gustavo G. Nascimento, Stina Baake, Lisa D. Pedersen, Flemming Scheutz, and Rodrigo López. "Impact of Smoking Cessation on Periodontitis: A Systematic Review and Meta-analysis of Prospective Longitudinal Observational and Interventional Studies." Nicotine & Tobacco Research 21, no. 12 (July 13, 2018): 1600–1608. http://dx.doi.org/10.1093/ntr/nty147.
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Abstract Aims This systematic review aimed to estimate the effect of tobacco smoking cessation on the risk for periodontitis compared to the risk among never-smokers and to evaluate the effect of tobacco smoking cessation on the clinical outcomes of nonsurgical periodontal treatment. Methods Electronic searches were performed in PubMed, Scopus, and Embase. Search strategy included MeSH and free terms: periodontitis, periodontal diseases, smoking, tobacco use, tobacco, tobacco products, cigarette, pipe, and cigar. Only original prospective longitudinal observational and interventional studies that investigated the association between smoking cessation and periodontitis onset or progression were included. Meta-analyses were conducted to summarize the evidence. Results A total of 2743 articles were identified in electronic searches; out of which only six were included in the meta-analysis. Pooled estimates showed that the risk of periodontitis incidence or progression among those who quit smoking was not significantly different from the risk for never-smokers (risk ratio [RR] = 0.97; 95% confidence interval [CI] = 0.87% to 1.08%). Smokers had approximately 80% higher risk of periodontitis than quitters (RR = 1.79; 95% CI = 1.36% to 2.35%) and never-smokers (RR = 1.82; 95% CI = 1.43% to 2.31%). Periodontal therapy resulted in up to 0.2 mm (95% CI = −0.32% to −0.08%) higher gain in attachment level and extra 0.32 mm (95% CI = 0.07% to 0.52%) reduction in pocket depth among quitters over nonquitters after short follow-up (12–24 months). Conclusions Few studies on the topic were identified. Smoking cessation reduced the risk for periodontitis onset and progression, and improved the outcomes of nonsurgical periodontal therapy. Implications This review provides the first quantitative evidence of the impact of smoking cessation on the risk for periodontitis onset and progression. The findings have demonstrated that the risk for periodontitis becomes comparable to that of never-smokers and that nonsurgical periodontal treatment outcomes improve after smoking cessation. Dental professionals ought to consider smoking cessation interventions as a relevant component of the periodontal therapy.
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Ju, Xiangqun, Jane Harford, Liana Luzzi, Gloria Mejia, and Lisa M. Jamieson. "A Longitudinal Study of Chronic Periodontitis in Two Cohorts of Community-Dwelling Elderly Australians." International Journal of Environmental Research and Public Health 19, no. 18 (September 19, 2022): 11824. http://dx.doi.org/10.3390/ijerph191811824.
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Background: The study aimed to estimate and compare the incidence and progression of chronic periodontitis among two generations of older Australian adults. Methods: Data were from two population-based cohort studies of Australian older adults aged 60+ years South Australian Dental Longitudinal Studies (SADLS), SADLS I (1991–1992) and SADLS II (2013–2014). American Academy of Periodontology/the U.S. Centres for Disease Control and Prevention (CDC/AAP), and the 2018 European Federation of Periodontology classification (EFP/AAP) case definitions were used to define and calculate the incidence and progression of chronic periodontitis. Multivariable Poisson regression models were used to estimate incidence risk ratios (IRRs) of periodontitis. Results: A total 567 and 201 dentate respondents had periodontal exams in SADLS I and II, respectively. The incidence rate was greater in SADLS II than in SADLS I, approximately 200 vs. 100/1000 person years, respectively. Current smokers had more than two times higher IRRs, 2.38 (1.30–4.34) and 2.30 (1.24–4.26), than their non-smoking counterparts in the previous generation under the CDC/AAP and EFP/AAP, respectively. Conclusions: The most recent generation of older adults has greater incidence and progression of periodontitis than the previous generation. Being a current tobacco smoker was a significant risk factor for both the incidence and progression of periodontitis.
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Khammissa, R. A. G., R. Ballyram, Y. Jadwat, J. Fourie, J. Lemmer, and L. Feller. "Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis." International Journal of Dentistry 2018 (October 1, 2018): 1–9. http://dx.doi.org/10.1155/2018/7315797.
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The biologically active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D) and its receptor, the vitamin D receptor (VDR), play roles in maintaining oral immunity and the integrity of the periodontium. Results of observational cross-sectional clinical studies investigating the association between vitamin D serum level and the incidence and severity of chronic periodontitis indicate that, perhaps owing to the immunomodulatory, anti-inflammatory, and antibacterial properties of 1,25(OH)2D/VDR signalling, a sufficient serum level of vitamin D is necessary for the maintenance of periodontal health. In cases of established chronic periodontitis, vitamin D supplementation is associated with reduction in the severity of periodontitis. As cross-sectional studies provide only weak evidence for any causal association and therefore are of questionable value, either longitudinal cohort studies, case controlled studies, or randomized control trials are needed to determine whether or not deficiency of vitamin D is a risk factor for chronic periodontitis, and whether or not vitamin D supplementation adjunctive to standard periodontal treatment is in any way beneficial. In this article, we discuss the relationship between vitamin D, oral immunity and periodontal disease and review the rationale for using vitamin D supplementation to help maintain periodontal health and as an adjunct to standard periodontal treatment.
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Yan, Gabriel Lee Keng, Mei Na Tan, Mun Loke Wong, Chong Meng Tay, and Patrick Finbarr Allen. "Functional Dentition, Chronic Periodontal Disease and Frailty in Older Adults—A Narrative Review." International Journal of Environmental Research and Public Health 20, no. 1 (December 28, 2022): 502. http://dx.doi.org/10.3390/ijerph20010502.
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Background: The likelihood of experiencing the impact of chronic disease rises with age, and cumulative functional deficits over time increase the risk of frailty in older adults. The exact causes of frailty are not clear, and research is needed to identify appropriate intervention measures to reduce risk of developing frailty in old age. Objective: To review the evidence on the relationship between frailty, dental status and chronic periodontitis and to determine if improvements in oral health of older adults can contribute to reversal of frailty. Results: The oral cavity is the entry point to the gastro-intestinal tract, and natural teeth facilitate efficient mastication of food prior to swallowing and subsequent digestion. The loss of natural teeth, which is gradual and cumulative over the life course, is associated with diminished nutritional intake, especially in older adults. Furthermore, chronic periodontitis has been postulated as a risk factor for frailty. The evidence supporting a strong relationship between oral health status and frailty is not clearcut. Cross sectional studies suggest an association with missing teeth and chronic periodontal inflammation. However, there are very few longitudinal studies and accordingly, it is not currently possible to claim a causal relationship. As yet, there is no evidence to suggest that improvements in oral health contribute to reversal of frailty. Conclusion: Longitudinal studies with robust designs are required to better inform the relationship across functional dentition, chronic periodontitis and frailty in older adults.
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de Vries, Charlotte, Guillermo Ruacho, Elin Kindstedt, Barbara Aleksandra Potempa, Jan Potempa, Björn Klinge, Pernilla Lundberg, Elisabet Svenungsson, and Karin Lundberg. "Antibodies to Porphyromonas gingivalis Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction." Journal of Clinical Medicine 11, no. 4 (February 15, 2022): 1008. http://dx.doi.org/10.3390/jcm11041008.
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There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria Porphyromonas gingivalis (Pg) as one of the key drivers of periodontitis, we set out to investigate whether antibodies to Pg virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls (p < 0.0001), in individuals positive for anti-citrullinated protein antibodies (p = 0.04) and anti-dsDNA antibodies (p = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls (p = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations.
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Mootha, Archana, Sankari Malaiappan, N. D. Jayakumar, Sheeja S. Varghese, and Julie Toby Thomas. "The Effect of Periodontitis on Expression of Interleukin-21: A Systematic Review." International Journal of Inflammation 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3507503.
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Purpose.Inflammation and tissue breakdown are led by an array of inflammatory destructive mediators associated with initiation and progression of inflammatory diseases like periodontitis. Current evidence shows that these inflammatory mediators have a definitive role in the pathogenesis of various systemic diseases with an inflammatory component. Interleukin-21 (IL-21) has been associated with systemic diseases like rheumatoid arthritis and Crohn’s disease that follow a chronic inflammatory cascade. Similarly recent studies have associated Interleukin-21 levels with periodontitis. This systematic review was aimed to assess the levels of IL-21 in subjects with periodontitis.Methods.A complete literature search was done in PubMed, Medline, Science Direct, and Cochrane databases and Google Scholar based on the inclusion/exclusion criteria. Six relevant articles were procured. Full text was read individually by two reviewers and data extraction was done based on STROBE statement.Results.After data extraction five observational and one interventional study were obtained. All the studies showed an increased expression of IL-21 in periodontitis and the interventional study showed reduction in IL-21 levels after nonsurgical periodontal therapy (NSP).Conclusion.Interleukin-21 levels are higher in periodontitis than controls. With this limited evidence further longitudinal studies are required to consider this as a definitive inflammatory marker.
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Bortolini, Bruna Martinazzo, Pedro Henrique de Carli Rodrigues, Lidiane Ura Afonso Brandão, Danielle Shima Luize, Gladson Ricardo Flor Bertolini, Carlos Augusto Nassar, and Patricia Oehlmeyer Nassar. "BONE TISSUE BEHAVIOR OF RATS WITH EXPERIMENTAL PERIODONTITIS SUBJECTED TO PHYSICAL EXERCISE." Revista Brasileira de Medicina do Esporte 25, no. 2 (April 2019): 133–36. http://dx.doi.org/10.1590/1517-869220192502170693.
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ABSTRACT Introduction: It is possible that physical activity protects the periodontium by mitigating excessive inflammatory response of the individual. There is some evidence from longitudinal studies and a prospective study demonstrating that physically active adults have experienced a decrease in the risk of periodontitis. To date no study has jointly explored the relationship of physical activity and periodontitis using inflammatory biomarkers. Objective: In this regard, the objective was to assess the bone tissue behavior of rats with experimental periodontitis subjected to aquatic exercise. Methods: Twenty-four male Wistar rats were divided into four groups: 1) without periodontitis and without exercise (CS); 2) without periodontitis and with exercise (CE); 3) with periodontitis and without exercise (DPS); 4) with periodontitis and with exercise (DPE). The animals from groups CE and DPE had swimming sessions for four weeks and the DPS and DPE groups were subjected to ligature-induced periodontitis. After 30 days the animals were sacrificed, and had their right and left hemimandibles removed for radiographic and histological analysis. The data obtained were analyzed and evaluated through ANOVA and Tukey tests. Results: Bone loss in the animals from the DPE group was found to be significantly lower (61.7 ± 2.2; p <0.05) than in those from the DPS group (84.5 ± 1.2; p <0.05), while in terms of the number of osteoblasts (DPS=11.0 ± 1.4; DPE=10.7 ± 5.2) and osteocytes (DPS=17.3 ± 3.1; DPE=19.0 ± 4.4), there was no significant decrease (p <0.05) in the groups subjected to experimental periodontitis, regardless of physical exercise. Conclusion: Physical exercise was found to have a protective effect in relation to bone height and did not influence bone density. Level of evidence II; Therapeutic studies - investigation of treatment results.
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Qi, Xiang, Zheng Zhu, and Bei Wu. "Reciprocal Association Between Cognitive Function and Oral Health: A Systematic Review and Meta-Analysis." Innovation in Aging 4, Supplement_1 (December 1, 2020): 158. http://dx.doi.org/10.1093/geroni/igaa057.514.
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Abstract Increasing evidence suggests that there is a linkage between cognitive function and oral health. However, there are few systematic reviews with meta-analysis have been conducted to evaluate the strength of this association. Moreover, existing studies usually focused on unidirectional associations between cognitive function and oral health; no research has demonstrated this inter-relationship in a longitudinal study. This study aims to systematically assess the magnitude of the bidirectional association between oral health and cognitive decline for studies using longitudinal data. Six international databases were searched up until December 31, 2019. Random-effects pooled Risk Ratios (RRs) with 95% confidence intervals (CIs) were calculated. The grading of recommendations assessment, development, and evaluation (GRADE) system was used to assess the quality of evidence. From 13,251 potentially eligible articles, 54 longitudinal studies were included in the systematic review and 18 were in meta-analysis. Meta-analysis was performed for tooth loss and periodontitis disease. Random effects analysis showed, with statistically low heterogeneity, Risks of cognitive decline included suboptimal dentition (<20 teeth) (RR 1.44, 95% CI 1.03-3.65) and periodontitis diseases (RR 1.48, 95% CI 1.22-1.81). Cognitive decline was a risk factor for tooth loss (RR 1.54, 95% CI 1.23-9.69). The overall quality of evidence, however, was rated as very low. The result of this review highlights that cognitive decline is a risk factor for poor oral health, and older adults with suboptimal oral health appear to have an increased risk of cognitive impairment. More studies with rigorous designs are needed to further examine this association.
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Santana, Danilo Dias, Gilberto Kac, Pedro Paulo Teixeira dos Santos, Thainá Castro da Silva, Camila Benaim, Paula Guedes Cocate, Maria Beatriz Trindade de Castro, Berit Lilienthal Heitmann, and Amanda Rodrigues Amorim Adegboye. "Association between Pre-Pregnancy BMI and Inflammatory Profile Trajectories during Pregnancy and Postpartum in Brazilian Women with Periodontitis: The IMPROVE Trial." International Journal of Environmental Research and Public Health 19, no. 5 (February 25, 2022): 2705. http://dx.doi.org/10.3390/ijerph19052705.
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This study aimed to explore the association between pre-pregnancy BMI and longitudinal changes in inflammatory markers from the second trimester of pregnancy to 6–8 weeks postpartum in women with periodontitis. This is a secondary exploratory analysis of 68 women who took part in a feasibility clinical trial in Rio de Janeiro, Brazil. Inflammatory markers included C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), and matrix metalloproteinase-9 (MMP-9) blood concentrations at 11–22 (T0) and 30–36 gestational weeks (T1), and 6–8 weeks postpartum (T3). Longitudinal generalised linear mixed-effects models were used to identify possible associations between pre-pregnancy BMI and changes in concentrations of inflammatory markers. Pre-pregnancy excess weight (β = 4.39; 95% CI, 2.12–6.65) was significantly associated with increased CRP levels from pregnancy to postpartum. There were no significant associations between pre-pregnancy BMI and longitudinal changes in IL-6, IL-10 and MMP-9. Our findings provide evidence that a higher pre-pregnancy BMI may lead to increases in CRP levels during pregnancy in women with periodontitis, irrespective of the severity of clinical periodontal parameters. Further studies need to investigate if predictors of changes in inflammatory markers can be used as prognostic factors for gestational outcomes.
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Kellesarian, Sergio Varela, Hans Malmstrom, Tariq Abduljabbar, Fahim Vohra, Tammy Varela Kellesarian, Fawad Javed, and Georgios E. Romanos. "“Low Testosterone Levels in Body Fluids Are Associated With Chronic Periodontitis”." American Journal of Men's Health 11, no. 2 (September 21, 2016): 443–53. http://dx.doi.org/10.1177/1557988316667692.
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There is a debate over the association between low testosterone levels in body fluids and the occurrence of chronic periodontitis (CP). The aim of the present systematic review was to assess whether low testosterone levels in body fluids reflect CP. In order to identify studies relevant to the focus question: “Is there a relationship between low testosterone levels in body fluids and CP?” an electronic search without time or language restrictions was conducted up to June 2016 in indexed databases using different keywords: periodontitis, chronic periodontitis, periodontal diseases, testosterone, and gonadal steroid hormones. A total of eight studies were included in the present systematic review. The number of study participants ranged from 24 to 1,838 male individuals with ages ranging from 15 to 95 years. Seven studies measured testosterone levels in serum, two studies in saliva, and one study in gingiva. Four studies reported a negative association between serum testosterone levels and CP. Two studies reported a positive association between decreased testosterone levels in serum and CP. Increased levels of salivary testosterone among patients with CP were reported in one study; whereas one study reported no significant difference in the concentration of salivary testosterone between patients with and without CP. One study identified significant increase in the metabolism of testosterone in the gingiva of patients with CP. Within the limits of the evidence available, the relationship between low testosterone levels and CP remains debatable and further longitudinal studies and control trials are needed.
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Li, Xin, Hitesh Singh Chaouhan, Ching-Hao Li, Tung-Min Yu, I.-Kuan Wang, Cheng-Li Lin, Chi-Yuan Li, and Kuo-Ting Sun. "Higher Risk of Gastric Helicobacter pylori Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan." International Journal of Environmental Research and Public Health 18, no. 21 (November 7, 2021): 11678. http://dx.doi.org/10.3390/ijerph182111678.
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Periodontitis is the most prevalent chronic inflammatory oral disease that is characterized by tooth loss and is commonly associated with several systemic inflammatory diseases. Some epidemiological studies suggest that those suffering from periodontitis might be at a greater risk of developing gastric Helicobacter pylori (Hp) infection; however, evidence that showing the association between periodontitis and the risk of gastric Hp infection is less clear. We conducted a large-scale, population-based study in Taiwan with a 13-year follow-up period to evaluate the risk of gastric Hp in a periodontitis patient cohort. To conduct this study, we used epidemiological data from the Taiwanese Longitudinal National Health Insurance Research Database (NHIRD) from 2000 to 2013. We selected 134,474 participants (64,868 males and 69,606 females with a minimum age of 20 years), with and without periodontitis, and matched patient cohort groups for age, sex, index year, and co-morbidities. The Cox proportional hazards regression model was used to examine the risk of gastric Hp infection in patients with periodontitis. Patients with periodontitis exhibited a higher risk of developing gastric Hp infection compared to those individuals/groups without periodontitis (1.35 vs. 0.87 per 1000 person-years, adjusted the hazards ratio (aHR 1.52), and 95% confidence intervals (CIs) 1.38–1.67, p < 0.001). The risk of gastric Hp infection persisted even after stratifying by age (aHR = 1.96 (1.79–2.13) for 50–64 years and 1.70 (1.49–1.94) for ≥65 years), gender (aHR = 1.20 (1.11–1.29) for men), and presence of comorbidities of hypertension (aHR = 1.24 (1.11–1.38)), hyperlipidemia (aHR = 1.28 (1.14–1.42)), COPD (aHR = 1.45 (1.31–1.61)), CLD (aHR = 1.62 (1.47–1.77)) and CKD (aHR = 1.44 (1.04–1.99)). Overall, our findings showed that periodontitis patients have a greater risk for gastric Hp than individuals without periodontitis. Clinicians should perform regular good oral hygiene practices, along with newer treatments, for patients with periodontitis, especially those at higher risk of gastric Hp infection.
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Golub, L. M., H. M. Lee, M. E. Ryan, W. V. Giannobile, J. Payne, and T. Sorsa. "Tetracyclines Inhibit Connective Tissue Breakdown by Multiple Non-Antimicrobial Mechanisms." Advances in Dental Research 12, no. 1 (November 1998): 12–26. http://dx.doi.org/10.1177/08959374980120010501.
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A seminal experiment involving a germ-free rat model of connective tissue breakdown (followed soon thereafter by a series of in vitro studies) identified an unexpected non-antimicrobial property of tetracyclines (TCs). This ability of TCs to inhibit matrix metalloproteinases (MMPs) such as collagenase was found to reflect multiple direct and indirect mechanisms of action, and to be therapeutically useful in a variety of dental (e.g., adult periodontitis) and medical (e.g., arthritis, osteoporosis, cancer) diseases. The site on the TC molecule responsible for its MMP-inhibitory activity was identified which led to the development of a series of chemically modified non-antimicrobial analogs, called CMTs, which also have therapeutic potential but do not appear to induce antibiotic side-effects. Longitudinal double-blind studies on humans with adult periodontitis have demonstrated that a sub-antimicrobial dose of doxycycline (previously reported to suppress collagenase activity in the periodontal pocket) is safe and effective and has recently been approved by the FDA as an adjunct to scaling and root planing.
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Aljohani, Hind A. "Association between Hemoglobin Level and Severity of Chronic Periodontitis." Journal of King Abdulaziz University - Medical Sciences 17, no. 1 (January 1, 2010): 53–64. http://dx.doi.org/10.4197/med.17-1.6.
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The aim of this study is to investigate the association between hemoglobin level and the severity of chronic periodontitis. Data were collected from 124 systemically healthy chronic periodontitis patients, referred to the Division of Periodontology, Faculty of Dentistry, King Abdulaziz University. Medical history, dental history, and periodontal parameters such as bleeding on probing. Plus probing depth, clinical attachment loss and distance from cement-enamel junction to gingival margin, furcations, mobility and number of missing teeth] were recorded. Blood samples were collected to measure the hemoglobin level. The correlation between hemoglobin and the means of clinical attachment loss and bleeding on probing was insignificant. There was no significant difference in the mean hemoglobin level for individuals with different severity of periodontitis among male and females. The mean hemoglobin found to be insignificantly correlated with the number of missing teeth. No association between hemoglobin levels and periodontal status was found. Further longitudinal studies with larger sample size are needed to investigate this association, and the effect of periodontal treatment on hemoglobin level.
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Vazgytė, Jurgita, Ieva Vaškelytė, and Urtė Marija Sakalauskaitė. "EFFECTIVENESS OF PROBIOTICS AS AN ADJUNCT IN PERIODONTAL CARE." Health Sciences 31, no. 2 (April 20, 2021): 226–31. http://dx.doi.org/10.35988/sm-hs.2021.068.
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Relevance of the problem. Periodontitis is a multifactorial inflammatory disease related with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth-supporting apparatus. Treatment of periodontitis aims to prevent further disease progression, to minimize symptoms and perception of the disease, possibly to restore lost tissues and to support patients in maintaining a healthy periodontium. Scaling and root planning (SRP) is the gold standard for the treatment of periodontitis. For the reduction in bacterial recolonization probiotics have been suggested as promising agents not only to retard recolonization, but also to increase the number of beneficial bacteria and to modulate immunological parameters in the prevention and treatment of periodontal disease. Aim of the work. To find out and assess the data of clinical trials that proposes clinical outcomes of the adjunctive use of probiotic for 3 months after SRP in comparison to SRP combined with a placebo. Tasks: 1) ascertain and assess the recolonization of bacteria after active treatment of periodontitis; 2) clarify and evaluate clinical variables improvement after the usage of local adjunctives; 3) find out and assess the distinction between different probiotics strains. Material and methods. This literature review has been carried out in accordance with the PRISMA Statement [23]. Electronic literature review was performed using MEDLINE and ELSEVIER databases and the selection of the articles, published in English between 2010 and 2020 year. The search for publications was based on keywords and their combinations: chronic periodontitis, scaling and root planning, adjunct care, probiotics, supplements. Results. This literature review includes eight suitable studies that met the inclusion criteria. Conclusions. The qualitative findings of the studies showed that major part of the included trials reported significant improvement in clinical periodontal parameters in periodontitis patients with the adjunctive use of probiotics compared with control group. 75 % of included studies made with L. reuteri found probiotic containing L. reuteri usage as an adjunct therapy to be significant in the improvement of clinical parameters. Probiotic therapy could be used for managing periodontal diseases. This review puts a stress on L. reuteri effectiveness. However, further studies are needed to substantiate its longitudinal effect.
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Singh, Bhupinder, Lovepreet Kaur, Jasmeet Kaur, and Harkanwal Preet Singh. "Assessment of Alcohol Consumption as A Potential Risk Factor on Periodontal Attachment Loss: A Longitudinal Study." Biomedical and Pharmacology Journal 11, no. 3 (September 13, 2018): 1537–41. http://dx.doi.org/10.13005/bpj/1520.
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In this modern society of ours alcohol has become a tradition and this relationship is deeply rooted. Apart from other health risk issues, its use has also emerged as a possible risk factor for periodontitis in reported recent reviews. Numerous prospective studies are already reported in literature but lack of such longitudinal studies to review the association of alcohol consumption on periodontal health status of the patients are rare. The aim of this study was to assess the relationship of alcohol consumption as a potential risk factor on periodontal attachment loss. It is a population-based cohort study conducted for a period of 4 years. A total of 1385 individuals were included in the study and only 730 individuals were left for the follow up after 4 years. Alcohol consumption and clinical examination for clinical attachment loss was recorded for each patient. Majority of subjects belonging to age group 35-44yrs, 45-54 yrs and 55-64 yrs showed high frequency intake of alcohol. Overall when measured, alcohol consumption and CAL progression was found to be significantly higher in males as compared to females. The subjects who were high and chronic drinkers, had 40% higher risk for CAL progression than non-drinkers. We concluded a positive linear relationship of alcohol consumption and periodontal attachment loss with more pronounced effect on males as compared to females. Thus alcohol proves to be a potential risk factor in progression of periodontitis in both high and chronic alcohol dosage.
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Sharma, Anuj, A. R. Pradeep, N. M. Raghavendra, P. Arjun, and Rahul Kathariya. "Gingival Crevicular Fluid and Serum Cystatin C Levels in Periodontal Health and Disease." Disease Markers 32, no. 2 (2012): 101–7. http://dx.doi.org/10.1155/2012/279295.
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Cystatin C (CSTC) is an inhibitor of cysteine proteinases and could play a protective and regulatory role under inflammatory conditions. The present study was designed to assess the concentration of CSTC in gingival crevicular fluid (GCF) and serum, to find out their association if any, in periodontal health and disease. 30 subjects were selected divided into 3 groups consisting of 10 subjects in each group based on clinical parameters: periodontally healthy group, gingivitis group and chronic periodontitis group, while, chronic periodontitis group after 8 weeks of the treatment (scaling and root planing) constituted after periodontal therapy group. GCF and serum samples were collected from all subjects to estimate the levels of CSTC by ELISA. The mean CSTC concentration in GCF and serum was observed to be the highest in periodontitis group and lowest in periodontally healthy group with intermediate concentration in gingivitis group and after periodontal therapy group. CSTC concentration in GCF and serum increased proportionally with the severity of periodontal disease (from health to periodontitis group) and decreased after treatment. This suggests that CSTC increases with disease progression to prevent further periodontal degeneration and decreases after treatment due to bone metabolic homeostasis. Further, longitudinal prospective studies involving larger population are needed to confirm the findings of present study and to better understand the role of CSTC in the pathogenesis of periodontal diseases.
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Griroriev, Sergey, Svetlana Ssablina, Tat'yana Elovicova, Alla Zakroeva, Maria Dominykh, and Valeria Ivanova. "PATHOGENETIC PARALLELS OF OSTEOPOROSIS AND CHRONIC PERIODONTITIS. LITERATURE REVIEW." Actual problems in dentistry 18, no. 1 (May 17, 2022): 19–28. http://dx.doi.org/10.18481/2077-7566-22-18-1-19-28.
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Subject. Parallels in the pathogenesis of two severe diseases of the modern era, osteoporosis and periodontitis.
Objectives. To review domestic and international research on pathogenetic relationship between osteoporosis and periodontal pathology.
Methodology. In topic generalization, the review of publications (since 2016) available on PubMed, eLIBRARY, Web of Science, Scopus by keywords is made.
Conclusion. Research studies have shown that bone tissue in the orofacial region, though lesser than bones of axial skeleton, tends to develop osteoporosis. That is why patients with osteoporosis are recommended regular periodontal maintenance visits, especially when periodontal disease is diagnosed at the appointment or during the complex rehabilitation program for patients in osteoplastic and maxillofacial reconstructive surgery. Future controlled longitudinal studies may be useful in research of this relationship based on the features of osteogenesis in the both diseases. This literature review helps to develop modern views of pathogenetic relationship between osteoporosis and periodontitis, evaluate general risk factors, promote understanding of tools in the diagnostic process and interpretation of results. Moreover, with the help of this paper by knowing the cell and molecular structure of bone tissue and mechanisms of bone remodeling a dental practitioner can arrange a personalized follow-up strategy for patients in the risk group for the above two diseases timely engaging general practitioners in interdisciplinary and complex therapy of patients with periodontal pathology.
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Nascimento, Gustavo G., Fábio R. M. Leite, Peter Vestergaard, Flemming Scheutz, and Rodrigo López. "Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies." Acta Diabetologica 55, no. 7 (March 3, 2018): 653–67. http://dx.doi.org/10.1007/s00592-018-1120-4.
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Gangwar, Shilpi, Patel Umesh Bhai Becharbhai, Vaibhav Sheel, and Umesh Chandra Chaudhary. "Correlation between chronic periodontitis and rheumatoid arthritis: A periodontist perspective." Journal of Dental Specialities 9, no. 2 (December 15, 2021): 67–71. http://dx.doi.org/10.18231/j.jds.2021.017.
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In this study, we evaluate the relationship between rheumatoid arthritis (RA) and chronic periodontitis on the basis of clinical attachment present and severity of attachment loss in both the cases. First of all Diagnosis of rheumatoid arthritis and chronic periodontitis was performed, thereafter bacterial DNA extraction from blood serum sample and subgingival dental plaque of each group through PCR and later DNA purification through Spin protocol was performed, oligonucleotide primer was used to detect t.forcythia and PCR amplification was done to detect T. Denticola for both the groups .PBDNA was detected in both SGP and serum samples of both the groups. In SGP samples, Tannerella forsythia was more frequently detected as compared to serum samples of both the groups. In result theclinical attachment Level (CAL) was observed to be higher in RA group as compared to CP group. Comparison of CAL according to severity was also observed in both the groups which suggested that RA group has mild periodontitis as compared to CP group in which moderate to severe periodontitis was seen, Detection of periodontal bacterial DNA by PCR assay PBDNA was detected in both SGP and serum samples. In SGP samples, Tannerella forsythia was more frequently detected as compared to serum samples of both the groups. So these are two common chronic inflammatory diseases with a similar host-mediated pathogenesis. Current evidence suggests that an association exists between periodontitis and RA. Well-designed multicenter longitudinal clinical trials and studies with sufficient sample sizes are needed to ascertain the relationship between these two diseases and whether periodontal treatment can reduce the severity of RA or prevent its onset.
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Kellesarian, Sergio Varela, Michael Yunker, Hans Malmstrom, Khalid Almas, Georgios E. Romanos, and Fawad Javed. "Male Infertility and Dental Health Status: A Systematic Review." American Journal of Men's Health 12, no. 6 (June 23, 2016): 1976–84. http://dx.doi.org/10.1177/1557988316655529.
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A limited number of studies have reported an association between male factor infertility (MFI) and dental health status (DHS). The aim of the present study was to assess the association between DHS and MFI through a systematic review of indexed literature. To address the focused question—“Is there a relationship between DHS and MFI?”—indexed databases were searched up to March 2016 using various key words “infertility,” “periodontal disease,” “periodontitis,” “dental infection,” “caries,” and “odontogenic infection.” Letters to the editor, case reports, commentaries, historic reviews, and experimental studies were excluded. In total seven studies were included in the present systematic review and processed for data extraction. All the studies reported a positive association between MFI and DHS. The number of study participants ranged between 18 and 360 individuals. Results from six studies showed a positive association between chronic periodontitis and MFI. Three studies reported a positive relationship between MFI and odontogenic infections associated to necrotic pulp, chronic apical osteitis, and radicular cysts. One study reported a relationship between caries index and MFI. From the literature reviewed, there seems to be a positive association between MFI and DHS; however, further longitudinal studies and randomized control trials assessing confounders are needed to establish real correlation. Dentists and general practitioners should be aware that oral diseases can influence the systemic health. Andrological examination should include comprehensive oral evaluation, and physicians detecting oral diseases should refer the patient to a dentist for further evaluation.
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Adegboye, Amanda RA, Barbara J. Boucher, Johanne Kongstad, Nils-Erik Fiehn, Lisa B. Christensen, and Berit L. Heitmann. "Calcium, vitamin D, casein and whey protein intakes and periodontitis among Danish adults." Public Health Nutrition 19, no. 3 (May 4, 2015): 503–10. http://dx.doi.org/10.1017/s1368980015001202.
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AbstractObjectiveTo investigate whether intakes of Ca, vitamin D, casein and whey are associated with periodontitis and to investigate the possibility of interactions between them.DesignCross-sectional study. An Internet-based, 267-item FFQ was used to assess dietary intake. Intakes of casein (32·0 g/d), whey proteins (9·6 g/d) and vitamin D (5·8 μg/d) were classified as withinv.above the 50th percentile. Ca intake was classified as withinv.below age-specific recommendations. Severe periodontitis was defined as having ≥2 inter-proximal sites with clinical attachment loss ≥6 mm (not on the same tooth) and ≥1 inter-proximal site with pocket depth ≥5 mm. Since vitamin D influences Ca absorption, models were stratified by lower and higher (<5·8v. ≥5·8 µg/d) vitamin D intake.SettingDanish Health Examination Survey (DANHES) 2007–2008.SubjectsAdult participants (n3287) in the oral health study of DANHES 2007–2008.ResultsIntakes of Ca within recommendations (OR=0·76; 95 % CI 0·58, 0·99), whey ≥9·6 g/d (OR=0·75; 95 % CI 0·58, 0·97) and casein ≥32 g/d (OR=0·75 95 % CI 0·58, 0·97) were associated with lower likelihood of severe periodontitis after adjustment for age, gender, education, smoking, sucrose intake, alcohol consumption, number of teeth, daily brushing, regular visits to the dentist and chronic illness, irrespective of vitamin D intake levels. Intake of vitamin D alone was not associated severe with periodontitis.ConclusionsIntakes of Ca, casein and whey protein were inversely associated with periodontitis. Consumption of foods rich in Ca, casein and whey (e.g. dairy foods) should be promoted, as they may contribute to the prevention of periodontitis. Further longitudinal studies are required to confirm these associations.
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Lembo, Daniela, Francesco Caroccia, Chiara Lopes, Francesco Moscagiuri, Bruna Sinjari, and Michele D’Attilio. "Obstructive Sleep Apnea and Periodontal Disease: A Systematic Review." Medicina 57, no. 6 (June 21, 2021): 640. http://dx.doi.org/10.3390/medicina57060640.
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Background and Objectives: The objective of this study was to evaluate the association between periodontal disease and obstructive sleep apnea syndrome (OSAS). Materials and Methods: Electronic search using PubMed, Scopus, LILACS, and Cochrane library was carried out for randomized controlled trials, cohort, case-control, longitudinal and epidemiological studies on humans published from January 2009 until September 2020. The participants had to be male and female adults who were diagnosed with OSAS either by overnight polysomnography (carried out at a sleep laboratory or at home) or by a home sleep testing monitor (Apnea Risk Evaluation System). Methodological quality assessment was carried out using the Newcastle-Ottawa Quality Assessment Scale (NOS) for case-control studies while an adapted form of NOS was used for cross-sectional studies. Results: Ten studies fulfilled the inclusion criteria of our review, 5 were case-control studies, and 5 cross-sectional. Sample size ranged from 50 to 29,284 subjects, for a total of 43,122 subjects, 56% of them were male, their age ranged from 18 to 85 years old. The heterogeneity among the studies regarding the classification of periodontal disease, and the different methods for OSAS severity assessment, complicated the comparison among the studies. Conclusions: There is low evidence of a possible association between OSAS and periodontitis. The pathophysiological mechanism, cause-effect, or dose-response relationship are still unclear. Further studies are needed and should use a precise classification of OSAS subjects, while the new classification of periodontitis from the World Workshop of Chicago 2017 should be used for the periodontal assessment.
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Lauritano, Dorina, Alessandro Nota, Marcella Martinelli, Marco Severino, Michele Romano, Diego Rossi, and Silvia Caruso. "A hydrosilver gel for plaque control in adults affected by chronic periodontitis: Effects on the ‘red complex’ bacterial load. A prospective longitudinal pilot study using polymerase chain reaction analysis." International Journal of Immunopathology and Pharmacology 33 (January 2019): 205873841882521. http://dx.doi.org/10.1177/2058738418825212.
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In subjects affected by chronic periodontitis, the chemical control of plaque is a strategy aiming primarily at controlling infection and bacterial loading. The aim is to evaluate the bacterial loading of the so-called ‘red complex’ associated with a short-term use of a hydrosilver gel (HSG) by using an in vivo model in adult subjects affected by chronic periodontitis. This prospective short-term clinical trial involved 10 adult volunteers using a 15-day in vivo model. After receiving professional prophylaxis at baseline (t0), each volunteer performed daily applications of HSG at home. After 15 days (t1) from the first application, subgingival plaque samples were collected, and the bacterial loading of species belonging to the red complex was evaluated using polymerase chain reaction (PCR) analyses. The bacterial loading of the red complex showed no statistically significant difference between t0 and t1, although it tended to decrease. HSG can be used at home as an adjunct to domestic oral care because it seems a promising tool, but further studies are needed to involve a larger sample and a longer follow-up.
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Beck, J. D., P. N. Papapanou, K. H. Philips, and S. Offenbacher. "Periodontal Medicine: 100 Years of Progress." Journal of Dental Research 98, no. 10 (August 20, 2019): 1053–62. http://dx.doi.org/10.1177/0022034519846113.
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Periodontal medicine is a term used to describe how periodontal infection/inflammation may impact extraoral health. Periodontitis has been linked to over 50 systemic diseases and conditions. As part of the Journal of Dental Research’s Centennial Celebration, this narrative review discusses periodontal medicine research done over the past 100 y, with particular focus on the effects of periodontal disease on 3 pathological conditions: cardiovascular disease, diabetes mellitus, and adverse pregnancy outcomes. We selected 29 total studies that were the “first” of their kind, as they provided novel observations or contributed to shifting paradigms as well as important studies that made strong contributions to progress in understanding relationships to the systemic conditions. These studies were organized in an overview timeline and broken down into timelines by topic: cardiovascular disease ( n = 10), diabetes ( n = 12), and adverse pregnancy outcomes ( n = 7). Overall, the majority of cross-sectional, case-control, and longitudinal studies have revealed positive associations between poor periodontal status and cardiovascular disease, diabetes metabolic control, and a number of adverse pregnancy outcomes, and these associations are upheld in systematic reviews. Findings from randomized controlled trials testing the effects of periodontal therapy on systemic health outcomes were conflicting and inconsistent. While there has been a great deal of progress, we highlight lessons learned and make comments and suggestions on a number of key aspects, including the heterogeneity of case definitions of periodontal disease across studies, accounting for features of the periodontal phenotype that are most relevant to the biological link between periodontitis and systemic outcomes, the role of other comorbid inflammatory conditions, selection of study participants, and timing and intensity of the periodontal intervention.
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Park, Jung-Hyun, Jin-Woo Kim, Heajung Lee, Iksun Hong, and Tae-Jin Song. "Better Oral Hygiene Is Associated with a Decreased Risk of Meniere’s Disease: A Nationwide Cohort Study." Journal of Personalized Medicine 13, no. 1 (December 29, 2022): 80. http://dx.doi.org/10.3390/jpm13010080.
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To investigate the association of the oral health parameters with Meniere’s disease in a nationwide population-based longitudinal cohort database. The data of the participants who underwent an oral health screening by dentists in 2003 (n = 2,415,963) were retrieved from the National Health Insurance Database of the Korean National Health Insurance Service. The main outcome was the occurrence of Meniere’s disease, defined as two or more claims of the diagnostic code H810 with a previous audiometric examination. The occurrence of Meniere’s disease was analyzed using a Cox proportional hazard model according to the presence of periodontitis and the oral health examination findings, including missing teeth, the frequency of tooth brushing and dental scaling. Overall, the analysis included 2,240,282 participants. During a median follow-up of 16.7 years, Meniere’s disease developed in 112,106 (5.0%) participants. Poor oral health status was characterized by the presence of periodontitis (adjusted hazard ratio [aHR]: 1.18, 95% confidence interval [CI]: 1.14–1.22, p < 0.001) and an increased number of missing teeth (≥15; aHR: 1.25, 95% CI: 1.18–1.32, p < 0.001) was associated with an increased risk of Meniere’s disease. Better oral hygiene behaviors, such as frequent tooth brushing (≥3 per day; aHR: 0.75, 95% CI: 0.73–0.76, p < 0.001) and dental scaling within 1 year (aHR: 0.98, 95% CI: 0.97–0.99, p = 0.003) were negatively associated with the occurrence of Meniere’s disease. The presence of periodontitis and an increased number of missing teeth may augment the risk of the occurrence of Meniere’s disease. However, maintaining good oral hygiene through tooth brushing and dental scaling may be associated with a decreased risk of Meniere’s disease. Further studies should confirm the association between oral health and Meniere’s disease.
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Sbricoli, Luca, Elissar Bazzi, Edoardo Stellini, and Christian Bacci. "Systemic Diseases and Biological Dental Implant Complications: A Narrative Review." Dentistry Journal 11, no. 1 (December 29, 2022): 10. http://dx.doi.org/10.3390/dj11010010.
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The relationship between periodontitis and such systemic disorders as diabetes, cardiovascular disease and obesity has been extensively investigated. There is less scientific evidence available, however, regarding the influence of systemic diseases on the risk of late failure of dental implant rehabilitation due to peri-implantitis. The aim of the present study was to review the literature on the role of several common systemic disorders (diabetes, obesity, cardiovascular disease, hypertension and osteoporosis) in the onset of peri-implantitis. A database search initially yielded 2787 studies of potential interest published up to 1 March 2022 (993 in PubMed; 908 in Web of Science; and 886 in Scopus). After removing 1190 duplicate articles and checking the titles, abstracts and full texts for relevance, 70 articles were selected for the present analysis. Only cohort, case-control studies and clinical case series were considered. Most of the literature concludes for no association between diabetes, cardiovascular disease, hypertension or osteoporosis and the risk of peri-implantitis. On the other hand, almost all the studies that investigated obesity as a risk factor for implant rehabilitation found a positive association between the two. Further longitudinal studies are needed to better understand the effects of systemic diseases on rehabilitation with dental implants.
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Huang, Yung-Kai, Li-Chiu Yang, Yu-Hsun Wang, and Yu-Chao Chang. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study." International Journal of Environmental Research and Public Health 18, no. 4 (February 17, 2021): 1921. http://dx.doi.org/10.3390/ijerph18041921.
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Migraine is considered to be a neurovascular disease that manifests as a throbbing headache, possibly caused by the activation of the trigeminovascular system. Several studies have supported the role of inflammation in the pathogenesis of migraine. Chronic periodontitis (CP) is an infectious inflammatory disease triggered by bacterial products evoking an immune response which could result in the destruction of the periodontium. However, little is known about the longitudinal association between CP and migraine. In this study, we designed a nationwide population-based cohort study to investigate the risk of migraine and CP exposure in Taiwan. In total, 68,282 patients with CP were identified from the National Health Insurance Research Database (NHIRD), and 68,282 comparisons were randomly captured and matched by age, sex, monthly income, urbanization and comorbidities. The association between CP exposure and migraine risk was evaluated by Cox proportional hazards regression models. In this study, 785 migraine patients were identified in the CP cohort, and 641 migraine cases were found in the non-CP cohort. The incidence rate of migraine was significantly higher in the CP cohort than the non-CP cohort (adjusted HR: 1.21, 95% CI: 1.09–1.34, p < 0.001) during the 13-year follow-up period. Females had a 2.69-fold higher risk for migraine than males (95% CI: 2.38–3.04, p < 0.001). In summary, CP is associated with an increased risk of subsequent migraine in Taiwan.
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Sidash, Yu V., O. P. Kostyrenko, and V. N. Petrushanko. "EXPERIMENTAL STUDY OF FURCATION AREA AND PROSPECTS OF ITS COMPLEX TREATMENT." Ukrainian Dental Almanac, no. 2 (June 29, 2021): 49–53. http://dx.doi.org/10.31718/2409-0255.2.2021.09.
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Relevance. The issue of quality endodontic treatment of teeth with complicated caries is still known as requiring thoughtful research. A significant percentage of periodontitis occurs in the area of furcations of multi-rooted teeth, sometimes alone, but more often as combined with apical periodontitis. Among the number of unsolved tasks, there is question about furcation areas and in particularly their antiseptic treatment and obturation in the complex treatment of chronic apical periodontitis of multi-rooted teeth.
Aim: to investigate the histo-morphological features of the furcation area of the first, second molars of the upper and lower jaws and, according to the results of the experimental study, to develop a scheme of complex treatment of chronic apical periodontitis of multi-rooted teeth.
Materials and methods. Ten first and second molars of both jaws not affected by fluorosis and removed according to orthodontic or surgical indications in patients aged from 25 to 50 years, were used for this study. In the first stage, transverse and longitudinal sections of the molars were made using diamond-coated separation disks. Using an orthopaedic tip, the first half of the molars were cut longitudinally in the mesio-distal direction with separation disks, under water cooling. The other half of the molars were cut transversely along the neck of the tooth and histochemically stained. In the second stage of the study, we used the experimental application of photodynamic therapy for antiseptic treatment of furcation channels and sealing them with citrate buffer. For this purpose, the next two first and two second mandibular molars were selected, respectively dissected in two planes. Samples were fixed in a vertical position; cotton rolls soaked with 2% methylene blue were placed onto the bottom of each half for 30 s., 1 min., 5 min., and 24 h. In this study we used light binocular stereoscopic microscope MBS-9; histochemical dyes: CHIC-thionine, ammonia silver solution "Argentat", reducing agent (hydroquinone), methylene blue, device "UFL - 122" company "Lux Dent", citrate buffer solution and white clay. The results were recorded with a digital camera mounted on a microscope tube.
Results and discussion. The results of histochemical examination of ten molars showed the presence of furcation channels in four teeth. Two samples were stained with CHIC-thionine, the others were stained with two-component "Argenate". The selected samples were dissected in the sagittal plane through the area of localization of the furcation channels and studied under the microscope (magnification: 8x32). In teeth dissected in the transverse plane, the crown and mouth pulp were instrumentally removed without dilation of the root canals and stained accordingly.
Thus, when modelling the stage of photodynamic treatment using a 2% solution of methylene blue, there is a significant filling of furcation channels and root canals along their entire length. The photosensitizer 2% methylene blue at the exposure of 30s demonstrates the highest efficiency at the minimum staining of surrounding fabrics. The microscopy was performed to confirm the ability of the photosensitizer to penetrate into the furcation channels at х8 – х32 magnification.
After the experimental filling of furcation channels and root canals, we can see clear white stripes along their entire length on the dentin surface of the longitudinal section of the root; these stripes are obliquely directed towards the canal surface and consist of numerous dentinal tubules impregnated with citrate buffer. Numerous thin white lines are clearly visible on the surface of the section that run in parallel, tangentially through almost the entire thickness of the root wall and end up their course in the area around the peripulpal dentin. This indicates the formation of calcium citrate in the root canal that tightly covers its entire surface impregnating the dentinal tubules and completely fills them along their entire length.
Therefore, the experimental model of using 2% methylene blue photosensitizer at a 30 s. exposure for photodynamic therapy and citrate buffer for obturating furcation and root canals can be applied in the treatment of patients with chronic apical periodontitis and lesions of the furcation area.
Conclusions. Thus, morphological studies of the first and second molars of both jaws have shown the presence of furcation channels, which anatomical structure is quite complex and demanding in terms of their antiseptic treatment and filling. Therefore, we developed new effective for disinfection and obturation techniques including applying photodynamic therapy for disinfection of furcation channels and citrate buffer for their obturation.
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Kouanda, Bakey, Zeeshan Sattar, and Patrick Geraghty. "Periodontal Diseases: Major Exacerbators of Pulmonary Diseases?" Pulmonary Medicine 2021 (November 2, 2021): 1–10. http://dx.doi.org/10.1155/2021/4712406.
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Periodontal diseases are a range of polymicrobial infectious disorders, such as gingivitis and periodontitis, which affect tooth-supporting tissues and are linked to playing a role in the exacerbation of several pulmonary diseases. Pulmonary diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, tuberculosis, COVID-19, and bronchiectasis, significantly contribute to poor quality of life and mortality. The association between periodontal disease and pulmonary outcomes is an important topic and requires further attention. Numerous resident microorganisms coexist in the oral cavity and lungs. However, changes in the normal microflora due to oral disease, old age, lifestyle habits, or dental intervention may contribute to altered aspiration of oral periodontopathic bacteria into the lungs and changing inflammatory responses. Equally, periodontal diseases are associated with the longitudinal decline in spirometry lung volume. Several studies suggest a possible beneficial effect of periodontal therapy in improving lung function with a decreased frequency of exacerbations and reduced risk of adverse respiratory events and morbidity. Here, we review the current literature outlining the link between the oral cavity and pulmonary outcomes and focus on the microflora of the oral cavity, environmental and genetic factors, and preexisting conditions that can impact oral and pulmonary outcomes.
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Matteson, S. R., S. T. Deahl, M. E. Alder, and P. V. Nummikoski. "Advanced Imaging Methods." Critical Reviews in Oral Biology & Medicine 7, no. 4 (October 1996): 346–95. http://dx.doi.org/10.1177/10454411960070040401.
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Recent developments in imaging sciences have enabled dental researchers to visualize structural and biophysical changes effectively. New approaches for intra-oral radiography allow investigators to conduct densitometric assessments of dento-alveolar structures. Longitudinal changes in alveolar bone can be studied by computer-assisted image analysis programs. These techniques have been applied to dimensional analysis of the alveolar crest, detection of gain or loss of alveolar bone density, peri-implant bone healing, and caries detection. Dental applications of computed tomography (CT) include the detailed radiologic anatomy of alveolar processes, orofacial soft tissues and air spaces, and developmental defects. Image analysis software permits bone mass mineralization to be quantified by means of CT data. CT has also been used to study salivary gland disease, injuries of the facial skeleton, and dental implant treatment planning. Magnetic resonance imaging (MRI) has been used extensively in retrospective and prospective studies of internal derangements of the temporomandibular joint. Assessments based on MRI imaging of the salivary glands, paranasal sinuses, and cerebrovascular disease have also been reported. Magnetic resonance spectroscopy (MRS) has been applied to the study of skeletal muscle, tumors, and to monitor the healing of grafts. Nuclear imaging provides a sensitive technique for early detection of physiological changes in soft tissue and bone. It has been used in studies of periodontitis, osteomyelitis, oral and maxillofacial tumors, stress fractures, bone healing, temporomandibular joint, and blood flow. This article includes brief descriptions of the technical principles of each imaging modality, reviews their previous uses in oral biology research, and discusses potential future applications in research protocols.
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Pouly, Sandrine, Wee Teck Ng, Muriel Benzimra, Alexandre Soulan, Nicolas Blanc, Filippo Zanetti, Patrick Picavet, Gizelle Baker, and Christelle Haziza. "Effect of Switching to the Tobacco Heating System Versus Continued Cigarette Smoking on Chronic Generalized Periodontitis Treatment Outcome: Protocol for a Randomized Controlled Multicenter Study." JMIR Research Protocols 10, no. 1 (January 18, 2021): e15350. http://dx.doi.org/10.2196/15350.
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Background Smoking is a significant risk factor for periodontal disease and tooth loss, as shown in several clinical studies comparing smokers and nonsmokers. Although only a few longitudinal studies have assessed the outcome of periodontal disease after smoking cessation, they indicated that recovery after nonsurgical treatment was more successful in those who had quit smoking. As part of tobacco harm reduction strategies, substituting cigarettes with alternative, less harmful tobacco products is an approach complementary to cessation for smokers who would otherwise continue to smoke. The Tobacco Heating System (THS), developed by Philip Morris International (commercialized as IQOS), is part of the heat-not-burn product category. The IQOS device electrically heats tobacco instead of burning it, at much lower temperatures than cigarettes, thereby producing substantially lower levels of harmful and potentially harmful constituents, while providing the nicotine, taste, ritual, and a sensory experience that closely parallel those of cigarettes. Phillip Morris International has published the results from a broad clinical assessment program, which was established to scientifically substantiate the harm reduction potential of the THS among adult healthy smokers switching to the THS. The program is now progressing toward including adult smokers with smoking-related diseases. Objective The goal of this study is to demonstrate favorable changes of periodontal endpoints in response to mechanical periodontal therapy in patients with generalized chronic periodontitis who completely switched to THS use compared with continued cigarette smoking. Methods This is a randomized controlled two-arm parallel-group multicenter Japanese study conducted in patients with chronic generalized periodontitis who switch from cigarettes to THS compared with smokers continuing to smoke cigarettes for 6 months. The patients were treated with mechanical periodontal therapy as per standard of care in Japan. The primary objective of the study is to demonstrate the beneficial effect of switching to THS use compared with continued cigarette smoking on pocket depth (PD) reduction in all sites with an initial PD≥4 mm. The secondary objectives include evaluation of other periodontal parameters (eg, clinical attachment level or gingival inflammation) and overall oral health status upon switching to THS. Safety was monitored throughout the study. Results In total, 172 subjects were randomized to the cigarette (n=86) or THS (n=86) groups, and all 172 completed the study. The conduct phase of the study is completed, while data cleaning and analyses are ongoing. Conclusions This study is the first to test a heat-not-burn tobacco product in smokers with an already established disease. The results should further strengthen the evidence that switching to THS can significantly reduce the risk of smoking-related diseases if favorable changes in the evolution of chronic generalized periodontitis after mechanical therapy are found when compared with continued cigarette smoking. Trial Registration ClinicalTrials.gov NCT03364751; https://clinicaltrials.gov/ct2/show/NCT03364751 International Registered Report Identifier (IRRID) DERR1-10.2196/15350
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Leppilahti, Jussi, Ulla Harjunmaa, Jorma Järnstedt, Charles Mangani, Marcela Hernández, Taina Tervahartiala, Rodrigo Lopez, et al. "Diagnosis of Newly Delivered Mothers for Periodontitis with a Novel Oral-Rinse aMMP-8 Point-of-Care Test in a Rural Malawian Population." Diagnostics 8, no. 3 (September 15, 2018): 67. http://dx.doi.org/10.3390/diagnostics8030067.
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A novel qualitative point-of-care test of activated matrix metalloproteinase-8 (aMMP-8) using noninvasive oral rinse sampling procedures has been developed for the early detection of collagen breakdown indicating periodontal tissue destruction. The main object of this study was to assess the reliability of the test in a low-income setting to identify participants with history of periodontal destruction detected as alveolar bone loss (ABL) in radiographs. This cross-sectional study included 486 women who had recently delivered in rural Malawi. The aMMP-8 test and dental panoramic radiographs were taken within 48 h of delivery. The performance of the test in comparison to radiological examinations was tested by following the standards for reporting of diagnostic accuracy studies protocol (STARD) with respective statistical measures and 95% confidence intervals. From the 486 eligible participants, 461 mothers with complete data, aged from 15 to 46 years (mean 24.8, SD 6.0) were included in the analysis. ABL was identified in 116 of 461 participants. There was 56% agreement between the aMMP-8 test results and detected ABL (yes or no) in radiographs. Calculated sensitivity of the test was 80% (72–87%), specificity 48% (43–54%), positive predictive value 34% (31–37%), negative predictive value 88% (83–91%), positive likelihood ratio 1.55 (1.35–1.77), and negative likelihood ratio 0.41(0.28–0.60). The aMMP-8 test sensitivity and negative predictive value to identify the ABL cases were relatively high, but there was additionally a high rate of test-positive results in participants without ABL, especially in young mothers, leading to low overall agreement between the test results and radiological bone loss. Further longitudinal studies are needed to examine if the test positive subjects are in risk of future bone loss before the detectable signs of periodontitis in radiographs.
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Loos, B. G., D. Mayrand, R. J. Genco, and D. P. Dickinson. "Genetic Heterogeneity of Porphyromonas (Bacteroides) gingivalis by Genomic DNA Fingerprinting." Journal of Dental Research 69, no. 8 (August 1990): 1488–93. http://dx.doi.org/10.1177/00220345900690080801.
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This study describes the use of total genomic DNA fingerprinting with the use of restriction endonucleases to characterize clinical isolates of Porphyromonas gingivalis (Bacteroides gingivalis) obtained from patients with periodontitis or with root-canal infections. The majority of independent isolates had a unique DNA fingerprint, indicating extensive genetic heterogeneity within this species. Twenty-nine distinct DNA fingerprints were found among the 33 isolates investigated. This is in contrast to biotyping and serotyping, where only one type and three types, respectively, have been reported. The observed heterogeneity indicates that DNA fingerprinting is a sensitive measure of genetic dissimilarity between P. gingivalis isolates and is able to characterize individual isolates. These results have ecological implications, indicating that there is considerable natural diversity in the global population of P. gingivalis, and that there are likely to be relatively large numbers of genetically distinct clonal lines. Furthermore, DNA fingerprinting is a sensitive and powerful tool for longitudinal and cross-sectional epidemiological studies. This technique provides far greater discrimination between isolates than either biotyping or serotyping, and will be most helpful in, for example, the analysis of distribution of clonal lines within one periodontal patient, or the analysis of the transmission to and turnover of strain populations within a patient population, since the probability of two strains with the same DNA fingerprint being found by chance is small.
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Fiorellini, Joseph P., Gianluca Martuscelli, and Hans Peter Weber. "Longitudinal studies of implant systems." Periodontology 2000 17, no. 1 (June 1998): 125–31. http://dx.doi.org/10.1111/j.1600-0757.1998.tb00130.x.
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Overholser, C. Daniel. "Longitudinal clinical studies with antimicrobial mouthrinses." Journal of Clinical Periodontology 15, no. 8 (September 1988): 517–19. http://dx.doi.org/10.1111/j.1600-051x.1988.tb01024.x.
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Pinto, Diogo, Andréa Marques, Joana F. Pereira, Paulo J. Palma, and João Miguel Santos. "Long-Term Prognosis of Endodontic Microsurgery—A Systematic Review and Meta-Analysis." Medicina 56, no. 9 (September 3, 2020): 447. http://dx.doi.org/10.3390/medicina56090447.
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Background and objectives: The long-term outcome of endodontic microsurgery (EMS) performed on root-filled teeth affected by post-treatment apical periodontitis (AP) has been a matter of debate, re-launched by the introduction of novel root-end filling materials which have been proven to improve the short-term outcome of EMS. The purpose of this systematic review and meta-analysis is to evaluate the clinical and radiographic long-term outcome of endodontic microsurgery in teeth diagnosed with secondary AP through radiographic evaluation. Materials and Methods: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion and exclusion criteria were defined a priori to select the best longitudinal evidence. Only randomized clinical trials (RCT) and prospective clinical studies (PCS), with a follow-up ≥ 2-year, and exhibiting well-established clinical and radiographic outcome criteria, were selected. Results: A total of 573 articles were obtained, from which 10 fulfill inclusion criteria: 6 PCS and 4 RCT. Meta-analysis showed a pooled proportion of success rate of 91.3%, from an overall amount of 453 treated teeth included in RCT; from overall 839 included teeth in PCS, a pooled success rate of 78.4% was observed, with the follow-up time ranging from 2 to 13-years. Survival rate outcomes varied from 79 to 100% for the same follow-up period. Five prognostic factors with influence on the outcome were disclosed: smoking habits, tooth location and type, absence/presence of dentinal defects, interproximal bone level, and root-end filling material. Conclusions: High success rates and predictable results can be expected when EMS is performed by trained endodontists, allowing good prognosis and preservation of teeth affected by secondary AP.
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Albrecht, K., P. De Pablo, T. Eidner, G. Hoese, S. Wassenberg, A. Zink, and J. Callhoff. "POS0026 ASSOCIATION BETWEEN RA DISEASE ACTIVITY AND TOOTH LOSS: RESULTS OF TWO NATIONAL COHORTS." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 216–17. http://dx.doi.org/10.1136/annrheumdis-2021-eular.658.
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Background:Cross-sectional studies suggest an association between the presence of tooth loss and/or periodontitis, cytokine levels and disease activity in patients with rheumatoid arthritis (RA) (1).Objectives:To analyze the association between tooth loss and disease activity/inflammatory activity in patients with early arthritis and established RA.Methods:Two data sources were used for analysis. Participants of the early arthritis cohort study CAPEA, conducted between 2010 and 2013, reported their number of teeth present at baseline and were followed over 2 years. Tooth loss categories were defined according to the number of teeth present, as follows: 0, 1-19, 19-27, and all 28 teeth. Disease activity/inflammatory activity data, such as disease activity scores (DAS28-ESR) and disease activity parameters, including swollen joint count (SJC) and inflammatory markers, i.e. erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were collected longitudinally at baseline, 3, 6, 12, 18, and 24 months. We used linear mixed regression models (with negative binomial distribution for SJC) to estimate the association between tooth loss and disease activity scores, SJC and inflammatory markers (ESR, CRP), over time. We also investigated the association between tooth loss and disease activity/inflammatory markers in patients with established RA, using cross-sectional data from the German National database (NDB) collected between 2015 and 2018. All models were adjusted for age, sex, smoking (ever vs. never), rheumatoid factor and education level, defined as years in education. Models with the NDB data were additionally adjusted for disease duration, missing data were imputed using multiple imputation. In all models, number of teeth was entered as a continuous variable.Results:Of a total of 1,124 CAPEA participants included, those with higher tooth loss were older, more often smokers, had a lower level of education, higher inflammatory markers and higher disease activity scores at baseline (Table 1). Inflammatory markers decreased comparably across all categories of tooth loss over time (Figure 1), in particular CRP. Tooth loss was not significantly associated with CRP or SJC alone. Glucocorticoid use was higher among those with more tooth loss, however dose reduction was similar across tooth loss categories. Among 7,179 NDB participants, adjusted disease activity scores and inflammatory markers were higher across tooth loss categories (DAS28 no teeth: 2.7, all teeth: 2.4; ESR no teeth: 23 mm/h, all teeth: 17 mm/h). SJC was not relevantly associated with tooth loss (no teeth: 1.2, all teeth: 1.2). Mean disease duration in the NDB sample was 13 years.Table 1.Early arthritis cohort (CAPEA) baseline characteristics, stratified by number of teethNumber of teeth presentTotaln01-1920-27All 28N893154522681,1241,124Female, %57656469651,124Age (years), mean69645445561,124ESR (mm), mean42382824311,074CRP (mg/l), mean25241515191,069SJC, mean6.16.95.65.25.91,120DAS28-ESR, mean5.55.24.74.54.9983RF positive, %63535254541,124Education, %1,020<=8 years80583521429-10 years163043463811-13 years412223320Smoking (ever), %73646156611,102ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, DAS28: disease activity score, RF: rheumatoid factor, SJC: swollen joint countFigure 1.Disease activity parameters during the 24-months follow-up, stratified by the number of teeth at baseline: results from mixed models, adjusted for age, sex, smoking and education level.Conclusion:While we observed a significant association between tooth loss and disease activity and inflammation markers in both early arthritis and established RA, our longitudinal results suggest that tooth loss has no influence on response to therapy.References:[1]Rodriguez-Lozano B, Gonzalez-Febles J, Garnier-Rodriguez JL, Dadlani S, Bustabad-Reyes S, Sanz M, et al. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case-control study. Arthritis Res Ther. 2019;21(1):27.Acknowledgements:We thank all participating rheumatologists and patients for their valuable contributions.The CAPEA periodontitis project was funded by the Deutsche Rheuma-Liga Bundesverband e.V.Capea was funded by an unconditional research grant from Pfizer.The National Database of the German Collaborative Arthritis centers has been supported since 2007 by the Association of Regional Cooperative Rheumatology Centres and joint contributions to the Rheumatological Training Academy and the DRFZ by the following members of the Working Group of Corporate Members of the German Society for Rheumatology: AbbVie, Actelion, BMS, GSK, Lilly, Medac, MSD, Novartis, Pfizer, Roche, Sanofi-Aventis and UCB. The researchers have full academic freedom.Disclosure of Interests:None declared.
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Machtei, E. E., R. Dunford, E. Hausmann, S. Grossi, J. Norderyd, and R. J. Genco. "A stepwise approach to determine periodontal attachment loss in longitudinal studies." Journal of Periodontal Research 28, no. 7 (November 1993): 536–39. http://dx.doi.org/10.1111/j.1600-0765.1993.tb02119.x.
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Rams, Thomas E., Jacqueline Oler, Max A. Listgarten, and Jorgen Slots. "Utility of Ramfjord index teeth to assess periodontal disease progression in longitudinal studies." Journal of Clinical Periodontology 20, no. 2 (February 1993): 147–50. http://dx.doi.org/10.1111/j.1600-051x.1993.tb00330.x.
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Döbereiner, Jürgen, and Klaus Dämmrich. "Are alveolar bone changes a determinant factor for "cara inchada" in cattle?" Pesquisa Veterinária Brasileira 17, no. 2 (April 1997): 45–48. http://dx.doi.org/10.1590/s0100-736x1997000200001.
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In order to study possible alterations of the skeleton which might play a role in the pathogenesis of the periodontitis of "cara inchada" in young cattle, ribs from 20 affected calves, 2 to 10 months old, were examined. Electrolytically decalcified longitudinal sections of the costochondral junction and cross sections through the corpus costae, stained with Haematoxylin-Eosin, were studied. In five calves, longitudinal sections of the proximal humerus were examined as well. The status of mineralization was checked by microradiograms. Systemic alteration of the skeleton due to disturbances of mineral metabolism could not be shown in any of the animals. In seven 2 to 4 months old calves, no bone changes were found. The reduced osteogenesis in six 3 to 5 months old calves and the reduced osteogenesis and diminished chondral growth in seven 5 to 10 months old calves are therefore a consequence of the disease. The results show that the development of the alveolar bone was not defective, so this cannot be a determinant factor for the development of the periodontitis of "cara inchada" in cattle.
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Berglundh, Tord, Leif Persson, and Björn Klinge. "A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of at least 5 years." Journal of Clinical Periodontology 29 (December 2002): 197–212. http://dx.doi.org/10.1034/j.1600-051x.29.s3.12.x.
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Garazha, Sergey, Elena Grishilova, Elizaveta Nekrasova, Irina Garazha, Tamerlan Hubaev, Ekaterina Ilina, and Fatima Hubaeva. "THE EFFECT OF LOW-INTENSITY LASER RADIATION ON THE EFFECTIVENESS OF COMPLEX TREATMENT OF GENERALIZED PERIODONTITIS." Actual problems in dentistry 15, no. 4 (February 12, 2020): 92–96. http://dx.doi.org/10.18481/2077-7566-2019-15-4-92-96.
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Subject. Periodontitis is an inflammatory and destructive process in periodontal tissues, the main etiological factor of which, according to modern concepts, is the microbial invasion of the gingival groove by qualitatively and quantitatively modified microorganisms of cervical plaque. Based on the etiopathogenetic bacterial-vascular mechanisms of the occurrence and progression of inflammatory and destructive periodontal diseases, the use of low-energy (low-intensity) laser exposure was included in all the algorithms for the comprehensive treatment of periodontitis that we studied.
Objective: to study the effect of low-intensity laser radiation in combination with local non-steroidal anti-inflammatory drugs on the effectiveness of complex treatment of periodontitis.
Methodology. The study involved 120 patients (60 men and 60 women), equally divided into four groups depending on the treatment performed. A randomized controlled trial with discrete longitudinal open observation was conducted.
The therapy included the implementation of professional oral hygiene using an ultrasound apparatus, sandblasting, polishing all surfaces of the teeth, a hygiene lesson, recommendations. The methodology of pharmacological treatment was to perform the application of the anti-inflammatory drugs Oralsept and Arkoxia to the periodontal area for 15 minutes with a course of 10 procedures. In the second and fourth groups, low-energy laser exposure was performed using the Optodan apparatus in the second mode for 15 minutes. The course of therapy was 10 procedures.
The clinical study was conducted according to generally accepted principles with mandatory x-ray control and an index assessment of the periodontal condition.
Results. After a six-month observation period, in the first and third groups, there was a deterioration in both index and hemodynamic digital data, and in the second and fourth indicators remained at a fairly positive level, indicating the effectiveness of the therapy.
Conclusions. The use of NLV increases the effectiveness of local exposure to non-steroidal anti-inflammatory drugs "Arkoxia" and "Oralsept" by 16 and 19 % respectively. The positive effect of NLV is maintained throughout the observation period.
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Caroline Schirmer, Alex Elias Lamas, and Daniel Demétrio Faustino-Silva. "Access and use of secondary dental care of a large city of Rio Grande do Sul, Brazil." RSBO 11, no. 4 (December 15, 2015): 375–81. http://dx.doi.org/10.21726/rsbo.v11i4.880.
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The Brazilian Dental Specialty Centers (CEOs) were created due to a limitation of Brazilian public dental care. In 2004, the specialized services corresponded to no more than 3.5% of total dental clinical procedures. These services are a reference for oral health teams in primary care in order to perform additional procedures at this level of attention. Despite the expansion of specialized procedures, the resolution of these services is subject to discussion between managers and researchers. Objective: To evaluate the access and use of the secondary dental care of a large city. Material and methods: The descriptive retrospective longitudinal study was conducted using CEO primary data from November 2012 to July 2013. These data were obtained from the Technical Department of Oral Health and the coordination of services were analyzed and then compared to the guidelines of Ordinance no. #1.464/MS. Results: The performance of services was low, ranging from 47.2 to 60.6% of the overall fulfillment of goals, in average. By analyzing per subgroup, endodontics was the subgroup with lower fulfillment (33.2%) and periodontics was that with the most fulfillment (88.3%). Absenteeism on the first appointments, the average per service ranged between 29.4 and 44.2%, and periodontics was the most affected subgroup (51%). The percentage of finished treatment ranged from 52.9 to 66.4%, and stomatology was the subgroup with less number of finished treatments (19.2%). Conclusion: The study revealed low utilization of the evaluated services associated with high absenteeism. Further studies and management initiatives are necessary to find ways to optimize secondary dental care integration to primary care services.
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Ramamurthy, Priyadarshini Hesarghatta, Bennete Aloysius Fernandes, Anand S. Tegginamani, Avita Rath, Preena Sidhu, and Ahmad Termizi Bin Zamzuri. "Clinical and cytological findings in oral cavity of young shisha smokers and non-smokers – a comparative study." Journal of Oral Medicine and Oral Surgery 28, no. 2 (2022): 15. http://dx.doi.org/10.1051/mbcb/2021050.
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Introduction: Shisha, a form of smoking tobacco is known to be detrimental to oral health. Yet, the effects of shisha on oral health is not well documented. Hence, this study was undertaken to compare the clinical and cytological findings in oral cavity of young shisha smokers as compared to non-smokers. Materials and methods: A cross-sectional analytical study was undertaken among 60 subjects including 30 young shisha smokers and 30 non-smokers. Clinical examination was carried out to record gingival status, periodontal status, oral hygiene and dental caries experience. Exfoliative cytology was used to study the cytological changes of buccal mucosal cells. Data was analysed using SPSS version 22. Student’s t-test, Fisher’s exact test and odd’s ration was used for comparison. p < 0.05 was considered statistically significant. Results: No significant differences were found between the groups with respect to proportion of subjects with gingivitis (p = 0.071), erosion (p = 0.085) and dental caries experience (p = 0.329). However, shisha smokers had poorer oral hygiene and more severe gingival inflammation as compared to non-smokers with p = 0.026 and p = 0.007 respectively. The odds of having atypical cells in oral mucosa among shisha smokers was 3.76 times higher than the non-smokers. Conclusion: The findings of our study showed that young shisha smokers had more atypical cells in oral mucosa as compared to their non-smoking counterparts. However, longitudinal studies are needed to affirm the findings of this study.
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Li, Xin-yu, Hui Liu, Lu-yu Zhang, and Xi-tao Yang. "The association of healthy eating index with periodontitis in National Health and Nutrition Examination Study 2011–2012." Frontiers in Nutrition 9 (September 26, 2022). http://dx.doi.org/10.3389/fnut.2022.999620.
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AimPeriodontitis is a chronic inflammatory disorder caused by periodontopathic bacteria that causes inflammation of the supporting tissues around teeth. Previous studies have found that daily dietary nutritional intake can influence the development of periodontal disease. However, research on the Healthy Eating Index’s involvement in periodontitis is limited. The purpose of this study was to look at the link between the Healthy Eating Index and periodontitis.Methods and designWe examined data from the National Health and Nutrition Examination Study (NHANES), a nationally representative survey that was performed in 2-year cycles from 2011 to 2012. As part of our investigation, we used multivariate logistic regression models to investigate the independent relationship between the Healthy Eating Index and periodontitis. We used odds ratios (OR) with 95% confidence intervals to assess the significance of the connection (95% CI).ResultsIndividuals with a lower total healthy eating index were more likely to have periodontitis. A higher healthy diet index was associated with a lower prevalence of periodontitis (OR = 0.69; 95%CI: 0.49–0.97), according to adjusted multivariate regression models. The restricted cubic spline (RCS) analysis revealed that the non-linear relationship between HEI-2015 and periodontitis was statistically significant and that high HEI-2015 reduced periodontitis prevalence.ConclusionThe study’s findings revealed that dietary structure was linked to the prevalence of periodontitis. Patients with a higher Healthy Eating Index were less likely to have periodontitis. There is a need for future prospective longitudinal studies to confirm causality.
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Holtfreter, B., B. Stubbe, S. Gläser, J. Trabandt, H. Völzke, R. Ewert, T. Kocher, T. Ittermann, and C. Schäper. "Periodontitis Is Related to Exercise Capacity: Two Cross-sectional Studies." Journal of Dental Research, March 3, 2021, 002203452199542. http://dx.doi.org/10.1177/0022034521995428.
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Although a potential link between periodontitis and cardiorespiratory fitness might provide a reasonable explanation for effects of tooth-related alterations seen on cardiometabolic diseases, evidence is currently limited. Thus, we investigated the association between clinically assessed periodontitis and cardiopulmonary exercise testing (CPET). Data from 2 independent cross-sectional population-based studies (5-y follow-up of the Study of Health in Pomerania [SHIP-1; N = 1,639] and SHIP-Trend-0 [ N = 2,439]) were analyzed. Participants received a half-mouth periodontal examination, and teeth were counted. CPET was based on symptom limited-exercise tests on a bicycle ergometer. Associations of periodontitis parameters with CPET parameters were analyzed by confounder-adjusted multivariable linear regression. In the total sample, mean pocket probing depth (PPD), mean clinical attachment levels, and number of teeth were consistently associated with peak oxygen uptake (peakVO2) and exercise duration in both studies, even after restriction to cardiorespiratory healthy participants. Statistically significant associations with oxygen uptake at anaerobic threshold (VO2@AT), slope of the efficiency of ventilation in removing carbon dioxide, and peak oxygen pulse (VÉ/VCO2 slope) occurred. Further, interactions with age were identified, such that mainly older individuals with higher levels of periodontal disease severity were associated with lower peakVO2. Restricted to never smokers, associations with mean clinical attachment levels and the number of teeth mostly diminished, while associations of mean PPD with peakVO2, VO2@AT, VÉ/VCO2 slope, and exercise duration in SHIP-1 and SHIP-Trend-0 were confirmed. In SHIP-1, mean peakVO2 was 1,895 mL/min in participants with a mean PPD of 1.6 mm and 1,809 mL/min in participants with a mean PPD of 3.7 mm. To conclude, only mean PPD reflecting current disease severity was consistently linked to cardiorespiratory fitness in 2 cross-sectional samples of the general population. If confirmed in well-designed large-scale longitudinal studies, the association between periodontitis and cardiorespiratory fitness might provide a biologically plausible mechanism linking periodontitis with cardiometabolic diseases.
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Li, Xin-yu, Ming-zhe Wen, Yu-hua Xu, Yu-chen Shen, and Xi-tao Yang. "The association of healthy eating index with periodontitis in NHANES 2013–2014." Frontiers in Nutrition 9 (August 9, 2022). http://dx.doi.org/10.3389/fnut.2022.968073.
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BackgroundPeriodontal disease is very common worldwide and is one of the main causes of tooth loss in adults. Periodontal disease is characterized by chronic inflammation that can destroy adjacent alveolar bone and lead to a loss of periodontal ligaments. Although previous studies have found that a daily diet can influence the development of periodontal disease (e.g., a diet low in carbohydrates and rich in vitamins C and D and fiber can have a protective effect). Periodontal disease may present as gingivitis or periodontitis. However, studies on the role of healthy eating index in periodontitis are lacking. The purpose of this study was to assess the association between healthy eating index and periodontitis.MethodsWe analyzed data collected from participants in the National Health and Nutrition Examination Survey (NHANES), a nationally representative survey conducted in 2-year cycles from 2013 to 2014. As part of our analysis, we developed multivariate logistic regression models to examine the independent association between the healthy eating index and periodontitis. We evaluated the significance of association using odds ratios (OR) with 95% confidence intervals (95%CI).ResultsIndividuals with a lower total healthy eating index had a higher prevalence of periodontitis. Adjusted multivariate regression models showed that a higher healthy diet index was associated with a lower prevalence of periodontitis (OR = 0.69, 95% CI: 0.55–0.86, P < 0.05).ConclusionThe results of the study showed that dietary structure was associated with the prevalence of periodontitis. Patients with a higher healthy eating index had a lower prevalence of periodontitis. These findings will need to be confirmed by longitudinal, prospective studies in the future.
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Jiang, Yaling, Bingqing Song, Bernd W. Brandt, Lei Cheng, Xuedong Zhou, Rob A. M. Exterkate, Wim Crielaard, and Dong Mei Deng. "Comparison of Red-Complex Bacteria Between Saliva and Subgingival Plaque of Periodontitis Patients: A Systematic Review and Meta-Analysis." Frontiers in Cellular and Infection Microbiology 11 (October 8, 2021). http://dx.doi.org/10.3389/fcimb.2021.727732.
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The development of periodontitis is associated with an imbalanced subgingival microbial community enriched with species such as the traditionally classified red-complex bacteria (Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola). Saliva has been suggested as an alternative to subgingival plaque for the microbial analysis due to its easy and non-invasive collection. This systematic review aims to determine whether the levels of red-complex bacteria assessed using saliva reflect those in subgingival plaque from periodontitis patients. The MEDLINE, EMBASE, and Cochrane Library databases were searched up to April 30, 2021. Studies were considered eligible if microbial data of at least one of the red-complex species were reported in both saliva and subgingival plaque from periodontitis patients, based on DNA-based methods. Of the 17 included studies, 4 studies used 16S rRNA gene sequencing techniques, and the rest used PCR-based approaches. The detection frequency of each red-complex species in periodontitis patients was reported to be > 60% in most studies, irrespective of samples types. Meta-analyses revealed that both detection frequencies and relative abundances of red-complex bacteria in saliva were significantly lower than those in subgingival plaque. Moreover, the relative abundances of all 3 bacterial species in saliva showed significantly positive correlation with those in subgingival plaque. In conclusion, current evidence suggests that one-time saliva sampling cannot replace subgingival plaque for microbial analysis of the red-complex bacteria in periodontitis patients. Given the positive microbial associations between saliva and subgingival plaque, a thorough review of longitudinal clinical studies is needed to further assess the role of saliva.
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Belstrøm, Daniel, Florentin Constancias, Daniela I. Drautz-Moses, Stephan C. Schuster, Mark Veleba, Frédéric Mahé, and Michael Givskov. "Periodontitis associates with species-specific gene expression of the oral microbiota." npj Biofilms and Microbiomes 7, no. 1 (September 23, 2021). http://dx.doi.org/10.1038/s41522-021-00247-y.
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AbstractThe purpose of the present investigation was to characterize species-specific bacterial activity of the oral microbiota in periodontitis. We tested the hypotheses that chronic inflammation, i.e., periodontitis, associates with bacterial gene expression of the oral microbiota. Oral microbial samples were collected from three oral sites—subgingival plaque, tongue, and saliva from patients with periodontitis and healthy controls. Paired metagenomics and metatranscriptomics were used to perform concomitant characterization of taxonomic composition and to determine species-specific bacterial activity as expressed by the ratio of specific messenger RNA reads to their corresponding genomic DNA reads. Here, we show the association of periodontitis with bacterial gene expression of the oral microbiota. While oral site was the main determinant of taxonomic composition as well as bacterial gene expression, periodontitis was significantly associated with a reduction of carbohydrate metabolism of the oral microbiota at three oral sites (subgingival plaque, tongue, and saliva). Data from the present study revealed the association of periodontitis with bacterial gene expression of the oral microbiota. Conditions of periodontitis was associated with bacterial activity of local subgingival plaque, but also on tongue and the salivary microbiota. Collectively, data suggest that periodontitis associates with impaired carbohydrate metabolism of the oral microbiota. Future longitudinal and interventional studies are warranted to evaluate the potential pathogenic role of impaired bacterial carbohydrate metabolism not only in periodontitis but also in other diseases with low-grade inflammation, such as type 2 diabetes mellitus.
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Meuric, Vincent, Sandrine Le Gall-David, Emile Boyer, Luis Acuña-Amador, Bénédicte Martin, Shao Bing Fong, Frederique Barloy-Hubler, and Martine Bonnaure-Mallet. "Signature of Microbial Dysbiosis in Periodontitis." Applied and Environmental Microbiology 83, no. 14 (May 5, 2017). http://dx.doi.org/10.1128/aem.00462-17.
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ABSTRACT Periodontitis is driven by disproportionate host inflammatory immune responses induced by an imbalance in the composition of oral bacteria; this instigates microbial dysbiosis, along with failed resolution of the chronic destructive inflammation. The objectives of this study were to identify microbial signatures for health and chronic periodontitis at the genus level and to propose a model of dysbiosis, including the calculation of bacterial ratios. Published sequencing data obtained from several different studies (196 subgingival samples from patients with chronic periodontitis and 422 subgingival samples from healthy subjects) were pooled and subjected to a new microbiota analysis using the same Visualization and Analysis of Microbial Population Structures (VAMPS) pipeline, to identify microbiota specific to health and disease. Microbiota were visualized using CoNet and Cytoscape. Dysbiosis ratios, defined as the percentage of genera associated with disease relative to the percentage of genera associated with health, were calculated to distinguish disease from health. Correlations between the proposed dysbiosis ratio and the periodontal pocket depth were tested with a different set of data obtained from a recent study, to confirm the relevance of the ratio as a potential indicator of dysbiosis. Beta diversity showed significant clustering of periodontitis-associated microbiota, at the genus level, according to the clinical status and independent of the methods used. Specific genera (Veillonella, Neisseria, Rothia, Corynebacterium, and Actinomyces) were highly prevalent (>95%) in health, while other genera (Eubacterium, Campylobacter, Treponema, and Tannerella) were associated with chronic periodontitis. The calculation of dysbiosis ratios based on the relative abundance of the genera found in health versus periodontitis was tested. Nonperiodontitis samples were significantly identifiable by low ratios, compared to chronic periodontitis samples. When applied to a subgingival sample set with well-defined clinical data, the method showed a strong correlation between the dysbiosis ratio, as well as a simplified ratio (Porphyromonas, Treponema, and Tannerella to Rothia and Corynebacterium), and pocket depth. Microbial analysis of chronic periodontitis can be correlated with the pocket depth through specific signatures for microbial dysbiosis. IMPORTANCE Defining microbiota typical of oral health or chronic periodontitis is difficult. The evaluation of periodontal disease is currently based on probing of the periodontal pocket. However, the status of pockets “on the mend” or sulci at risk of periodontitis cannot be addressed solely through pocket depth measurements or current microbiological tests available for practitioners. Thus, a more specific microbiological measure of dysbiosis could help in future diagnoses of periodontitis. In this work, data from different studies were pooled, to improve the accuracy of the results. However, analysis of multiple species from different studies intensified the bacterial network and complicated the search for reproducible microbial signatures. Despite the use of different methods in each study, investigation of the microbiota at the genus level showed that some genera were prevalent (up to 95% of the samples) in health or disease, allowing the calculation of bacterial ratios (i.e., dysbiosis ratios). The correlation between the proposed ratios and the periodontal pocket depth was tested, which confirmed the link between dysbiosis ratios and the severity of the disease. The results of this work are promising, but longitudinal studies will be required to improve the ratios and to define the microbial signatures of the disease, which will allow monitoring of periodontal pocket recovery and, conceivably, determination of the potential risk of periodontitis among healthy patients.