Relevant bibliographies by topics / Periodontal Guided Tissue Regeneration

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Academic literature on the topic 'Periodontal Guided Tissue Regeneration'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 January 2023

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Journal articles on the topic "Periodontal Guided Tissue Regeneration"

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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (June 1, 2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.

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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa soft tissue graft, bone graft, biomodifikasi akar gigi, guided tissue regeneration sertakombinasi prosedur-prosedur di atas, termasuk prosedur bedah restoratif yang berhubungan dengan rehabilitasi oral dengan penempatan dental implan. Pada tingkat selular, regenerasi periodontal adalah proses kompleks yang membutuhkan proliferasi yang terorganisasi, differensiasi dan pengembangan berbagai tipe sel untuk membentuk perlekatan periodontal. Rasionalisasi penggunaan guided tissue regeneration sebagai membran pembatas adalah menahan epitel dan gingiva jaringan pendukung, sebagai barrier membrane mempertahankan ruang dan gigi serta menstabilkan bekuan darah. Pada makalah ini akan dibahas sekilas mengenai 1. Proses penyembuhan terapi periodontal meliputi regenerasi, repair ataupun pembentukan perlekatan baru. 2. Periodontal spesific tissue engineering. 3. Berbagai jenis membran/guided tissue regeneration yang beredar di pasaran dengan keuntungan dan kerugian sekaligus karakteristik masing-masing membran. 4. Perkembangan membran terbaru sebagai terapi regenerasi penyakit periodontal. Tujuan penulisan untuk memberi gambaran masa depan mengenai terapi regenerasi yang menjanjikan sebagai perkembangan terapi penyakit periodontal. Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal system that could lead to the destruction of the periodontal tissue and end up with tooth loss. Currently, there are so many researches and efforts to regenerate periodontal tissue, not only to stop the process of the disease but also to reconstruct the periodontal tissue. Periodontal regenerative therapy aims at directing the growth of new bone, cementum and periodontal ligament on the affected teeth. Regenerative procedures consist of soft tissue graft, bone graft, roots biomodification, guided tissue regeneration and combination of the procedures, including restorative surgical procedure that is connected with oral rehabilitation with implant placement. At cellular phase, periodontal regeneration is a complex process with well-organized proliferation, distinction, and development of various type of cell to form attachment of periodontal tissue. Rationalization of the use of guided tissue regeneration as barrier membrane is to prohibit the penetration of epithelial and connective tissue migration into the defect, to maintain space, and to stabilize the clot. This research discusses: 1. Healing process on periodontal therapy including regeneration, repair or formation of new attachment. 2. Periodontal specific tissue engineering. 3. Various commercially available membrane/guided tissue regeneration in the market with its advantages and disadvantages and their characteristics. 4. Recent advancement of membrane as regenerative therapy on periodontal disease. In addition, this review is presented to give an outlook for promising regenerative therapy as a part of developing knowledge and skills to treat periodontal disease.
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Villar, Cristina C., and David L. Cochran. "Regeneration of Periodontal Tissues: Guided Tissue Regeneration." Dental Clinics of North America 54, no. 1 (January 2010): 73–92. http://dx.doi.org/10.1016/j.cden.2009.08.011.

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Petrović, Milica, Ljiljana Kesić, Radmila Obradović, Simona Stojanović, Branislava Stojković, Marija Bojović, Ivana Stanković, Kosta Todorović, Milan Spasić, and Nenad Stošić. "Regenerative periodontal therapy: I part." Acta stomatologica Naissi 37, no. 84 (2021): 2304–13. http://dx.doi.org/10.5937/asn2184304p.

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Introduction: Under the concept of regenerative periodontal therapy, there are two approaches: the first is the passive regeneration conceptthat includes bone substituents and guided periodontal regeneration by using of biomembranes and the second concept of active regeneration that impliesthe use of growth factors. The aim of the passive regeneration, by using of bone matrix (bone substituens) has been stabilization and bone defects management, preventing epithelial tissue growth, as well as saving space for the new tissue regeneration. This concept implies the use of autogenous transplantats, xenografts, allografts, as well as alloplastic materials. The carriers for active tissue regeneration, growth factors -GF are biological mediators that regulate cellular processes and that is crucial for the tissue regeneration. Aim:Presentation ofmodern approaches to periodontal therapy thatare focused on the attachment regeneration and complete reconstruction of periodontal tissue. Conclusion: In the future, periodontal regenerative therapy with periodontalligament progenitor cells should encourage repopulation of the areas that have been affected by periodontal disease.
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Bajpai, Devika. "Recent advances in GTR scaffolds." Bioinformation 18, no. 12 (December 31, 2022): 1181–85. http://dx.doi.org/10.6026/973206300181181.

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Periodontitis is a serious chronic inflammatory condition that can cause periodontal tissue deterioration and, eventually, tooth loss. Periodontal regenerative therapy using membranes and bone grafting materials, as well as flap debridement and/or flap curettage, have all been used with varying degrees of clinical effectiveness. Current resorbable and non-resorbable membranes serve as a physical barrier, preventing connective and epithelial tissue down growth into the defect and promoting periodontal tissue regeneration. The "perfect" membrane for use in periodontal regenerative therapy has yet to be created, as these conventional membranes have several structural, mechanical, and bio-functional constraints. We hypothesised in this narrative review that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) membranes for periodontal tissue engineering will be a graded-biomaterials that closely mimics the extracellular matrix.
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Malhotra, Ranjan, Anoop Kapoor, Vishakha Grover, Nitin Verma, and Jasjit Kaur Sahota. "Future of Periodontal Regeneration." Journal of Oral Health and Community Dentistry 4, Spl (2010): 38–47. http://dx.doi.org/10.5005/johcd-4-spl-38.

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ABSTRACT The management of periodontal defects has been an ongoing challenge in clinical periodontics. In the recent past, attention has been focused more on regenerative and reconstructive therapies i.e. bone grafts, guided tissue regeneration, root conditioning, polypeptide growth factors, rather than on respective therapies. These therapeutic measures are shown to be limited in the predictability of healing and regenerative response in the modern clinical practice because oral environment presents several complicating factors that border regeneration. The 21st century appears to represent a time in history when there is a convergence between clinical dentistry and medicine, human genetics, developmental and molecular biology, biotechnology, bioengineering, and bioinformatics, resulting in the emergence of novel regenerative therapeutic approaches viz. tissue engineering, gene therapy and RNA interference. The focus of this review paper is to furnish and update the current knowledge of periodontal tissue engineering, gene therapy and RNA interference i.e. the future of periodontal regeneration.
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Sankhyayan, Dr Akhilesh, Dr Anil Sharma, Vidushi Jindal, Dr Malvika Thakur, Dr Vikas Jindal, and Ayushi Singla. "Guided Tissue Regeneration – A Boon to Surgical Periodontal Therapy." International Journal of Innovative Science and Research Technology 5, no. 7 (July 27, 2020): 471–74. http://dx.doi.org/10.38124/ijisrt20jul416.

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Periodontitis has been a chronic inflammatory disease of the gingiva which eventually result in periodontal pocket formation with loss of the associated periodontal ligament and alveolar bone around teeth. Guided tissue regeneration (GTR), which is often a target for periodontal treatment, has the ability to promote periodontal regeneration. The development of the periodontal attachment is primarily concerned with tissue regeneration.Based on such concept, guided tissue regeneration is being utilized to varying degree of success to restore periodontal defects. In order to remove epithelium as well as gingival corium from the root and/or existing bone walls on the assumption that they interfere with regeneration, barrier techniques have been applied, using elements like expanded polytetrafluoroethylene, polyglactine, polylactic acid, calcium sulfate and collagen.
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Agus Susanto, Susi Susanah, Bambang Pontjo, and Mieke Hemiawati Satari. "MEMBRAN GUIDED TISSUE REGENERATION UNTUK REGENERASI PERIODONTAL." Dentika Dental Journal 18, no. 3 (July 1, 2015): 300–304. http://dx.doi.org/10.32734/dentika.v18i3.1980.

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Berbagai teknik bedah dan bahan terus dikembangkan untuk meningkatkan regenerasi periodontal. Salah satu metode bedahyang sering digunakan pada defek periodontal adalah menggunakan barriermembranguided tissue regeneration (GTR) atauguided bone regeneration (GBR). Prinsip GTR/GBR adalah menggunakan barriermembran untuk menutupi tulang danligamen periodontal, kemudian memisahkannya sementara dari epitel gusi. Fungsi membran ini meningkatkan dan menjagabekuan darah dan bertindak sebagai scaffold untuk perlekatan dan proliferasi sel. Terdapat dua jenis membran yaitumembran non resorbable dan resorbable. Membran non resorbable pada umumnya terbuat dari polytetrafluoroethylene,membran ini sifatnya stabil, nondegradable dan biokompatibel, tetapi penggunaannya memerlukan bedah kedua untukmengambil membran. Membran resorbable berasal dari bahan sintetis seperti polyglycolic, polylactic acid dan bahan alamiseperti kolagen dan laminar bone. Pembuatan membran yang ideal masih terus dikembangkan, membran kolagen saat inilebih sering digunakan karena mempunyai biocompatibility yang optimal walaupun tingkat resorpsi membran sulit untukdiprediksi.
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González-Jaranay, Maximino, María del Carmen Sánchez-Quevedo, Gerardo Moreu, José Manuel García, and Antonio Campos. "Electron Microprobe Analysis in Guided Tissue Regeneration: A Case Report." European Journal of Dentistry 01, no. 01 (January 2007): 40–44. http://dx.doi.org/10.1055/s-0039-1698310.

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ABSTRACTObjectives: Several procedures have been advocated as regenerative procedures in periodontology, but one of the most widely used techniques up to now is guided tissue regeneration (GTR). Likewise, different assessment methods based on clinical, radiographic or histological measurements have been proposed for the evaluation of these regenerative procedures. However, none of the methods used for human material incorporates quantitative X-ray microanalysis to assess the degree of mineralization of the regenerated periodontal hard tissues. The objective of this report was to evaluate, using quantitative X-ray microprobe analysis, the newly-formed hard tissue in a periodontal infrabony defect.Methods: Electron microprobe analysis was used to study the nature of the newly-formed hard tissue 3 years after treatment with guided tissue regeneration in a patient with localized aggressive periodontitis.Results: Our quantitative analyses, using the peak-to-background method, showed calcium/phosphorus mass ratio of 1.50±0.38 in the newly-formed hard tissue around the affected tooth root.Conclusion: Quantitative X-ray microprobe analysis is a useful tool that may provide an accurate assessment of the degree of mineralization in an extremely small tissue sample. (Eur J Dent 2007;1:40- 44)
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Deng, Rong, Yuzheng Xie, Unman Chan, Tao Xu, and Yue Huang. "Biomaterials and biotechnology for periodontal tissue regeneration: Recent advances and perspectives." Journal of Dental Research, Dental Clinics, Dental Prospects 16, no. 1 (May 29, 2022): 1–10. http://dx.doi.org/10.34172/joddd.2022.001.

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Periodontal tissues are organized in a complex three-dimensional (3D) architecture, including the alveolar bone, cementum, and a highly aligned periodontal ligament (PDL). Regeneration is difficult due to the complex structure of these tissues. Currently, materials are developing rapidly, among which synthetic polymers and hydrogels have extensive applications. Moreover, techniques have made a spurt of progress. By applying guided tissue regeneration (GTR) to hydrogels and cell sheets and using 3D printing, a scaffold with an elaborate biomimetic structure can be constructed to guide the orientation of fibers. The incorporation of cells and biotic factors improves regeneration. Nevertheless, the current studies lack long-term effect tracking, clinical research, and in-depth mechanistic research. In summary, periodontal tissue engineering still has considerable room for development. The development of materials and techniques and an in-depth study of the mechanism will provide an impetus for periodontal regeneration.
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Quin¯ones, Carlos R., and Raul G. Caffesse. "Current status of guided periodontal tissue regeneration." Periodontology 2000 9, no. 1 (October 1995): 55–68. http://dx.doi.org/10.1111/j.1600-0757.1995.tb00056.x.

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Dissertations / Theses on the topic "Periodontal Guided Tissue Regeneration"

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Gottlow, Jan. "New attachment formation by guided tissue regeneration." Göteborg : Dept. of Periodontology, University of Göteborg, 1986. http://catalog.hathitrust.org/api/volumes/oclc/17242123.html.

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Mayfield, Lisa. "Regeneration in periodontal and endosseous implant treatment." Malmö, Sweden : Dept. of Periodontology, Faculty of Odontology, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39457632.html.

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Hattingh, André Christiaan. "A protocol to study tissue regeneration in alveolar bony defects /." Access to E-Thesis, 1999. http://upetd.up.ac.za/thesis/available/etd-01052007-135643/.

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Borges, Ricardo Jorge Morais. "Regeneração periodontal de defeitos infra-ósseos." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5276.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária
A doença periodontal afeta grande parte da população, e a sua progressão pode levar à perda de inserção dos tecidos conetivos do periodonto assim como perda óssea. O tratamento periodontal procura essencialmente dois objetivos: impedir a progressão da doença e reconstruir os tecidos periodontais perdidos. O tratamento regenerativo surge como método para alcançar este segundo objetivo. Neste âmbito, ao longo do tempo têm sido desenvolvidas diversas técnicas regenerativas, sendo as proteínas de matriz de esmalte e a regeneração tecidular guiada as mais investigadas em ensaios clínicos. A revisão bibliográfica inicialmente foi realizada no motor de busca PubMed recorrendo a palavras-chave como: “Periodontal Regeneration”, “Intrabony Defects”, “Guided Tissue Regeneration” e “Enamel Matrix Proteins” tendo por base meta-análises publicadas, maioritariamente, nos últimos 10 anos. Posteriormente foram incluídos artigos como base litúrgica para abordar a parte teórica deste trabalho, sendo estes publicados entre 1958 e 2015.
Periodontal disease affects a large population and its progression may lead to the loss of attachment of periodontal connective tissue as well as bone loss. The periodontal treatment essentially seeks two objectives: preventing disease progression and rebuild the lost periodontal tissues. The regenerative treatment arises as a method to achieve this second goal. In this context, from time to time there have been developed several regenerative techniques, being the proteins of enamel matrix and guided tissue regeneration, the most investigated in clinical trials. The literature review was conducted initially in the search engine PubMed using keywords like "Periodontal Regeneration", "Intrabony Defects", "Guided Tissue Regeneration" and "Enamel Matrix Proteins" on the basis of published meta-analysis, mostly in the last 10 years. Later there were included items as a liturgical basis for in order to adress the theoretical part of this study, which were published between 1958 and 2015.
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Pereira, Sergio Luis da Silva. "Avaliação histologica e histometrica do uso de membramas não reabsorviveis e reabsorviveis em defeitos periodontais cirurgicamente criados em cães." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290833.

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Orientadores: Enilson Antonio Sallum, Antonio Wilson Sallum
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O objetivo deste trabalho foi comparar, histológica e histometricamente, o processo de cura de defeitos tipo deiscência tratados pela técnica de regeneração tecidual guiada (RTG) com membranas reabsorvíveis de ácido poliláctico e não reabsorvíveis de politetrafluoroetileno expandido (PTFE-e). Seis cães adultos fêmeas de raça indefinida foram utilizados. Defeitos ósseos tipo deiscência foram criados cirurgicamente nas raízes distais dos terceiros e quartos pré molares mandibulares de ambos os lados e expostos ao acúmulo de placa por 3 meses. Após este período, os defeitos foram aleatoriamente designados para um dos tratamentos: RTG com membrana reabsorvível de ácido poliláctico (Grupo 1), RTG com membrana não reabsorvível de PTFE-e (Grupo 2), raspagem e alisamento radicular manual com acesso cirúrgico (Grupo 3) e não tratado (Grupo 4). Após 3 meses do segundo procedimento cirúrgico, os cães foram sacrificados e os espécimes processados para permitir análise histológica e histométrica, incluindo. os seguintes parâmetros: extensão linear do epitélio sulcular e juncional, adaptação do tecido conjuntivo, novo cemento, extensão vertical do novo osso e nova área óssea. Uma extensão linear de novo cemento estatisticamente superior (P<0.05) foi observada nos sítios tratados pela RTG, independente do tipo de membrana utilizada, em comparação com o Grupo 3. Não houve diferença estatisticamente significante entre o Grupo 1 e 2 em todos os parâmetros avaliados, exceto em relação à área de novo osso. O grupo 1 apresentou uma área de novo osso estatisticamente superior a dos outros grupos (P<0.05). Dentro dos limites deste estudo pôde-se concluir que ambas as membranas foram igualmente efetivas em promover nova formação cementária e que a membrana reabsorvível de ácido poliláctico (não-suturada) providenciou uma maior área óssea em relação à membrana não reabsorvível de PTFE-e
Abstract: The goal of this investigation was to compare histollogically and histometrically the healing process of dehiscence-type defects treated by guided tissue regeneration (GTR) with resorbable polylactic acid membranes and nonresorbable ePTFE membranes. Six mongrel dogs were used. Buccal osseous dehiscences were surgically created on the distal roots of the mandibular third and fourth premolars. The defects were exposed to plaque accumulation for 3 months. After this period, the defects were randomly assigned to one ofthe treatments: GTR with resorbable membrane (GTR1), GTR with nonresorbable membrane (GTR2), open flap debridement (OFD) and non-treated control (NTC). After 3 months of healing, the dogs were sacrificed and the blocks were processed. The histometric parameters evaluated included: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone (vertical component) and new bone area. A superior length of new cementum was observed in the sites treated by GTR, regardless of the type of barrier used (P<0.05), in comparison with OFD. No statistically significant differences were found between GTRl and GTR2 in all the parameters with the exception ofbone area. GTRl presented a greater bone area (P<0.05) when compared to GTR2, OFD and NTC. Within the limits of this study, it can be concluded that both batriers are equally effective for new cementum formation. The resorbable membrane (non-sutured) may provide a better osseous response than the nonresorbable membrane
Doutorado
Periodontia
Doutor em Clínica Odontológica
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Moore, Edward Andrew. "Cell attachment and spreading on physical barriers used in periodontal guided tissue regeneration /." Oklahoma City : [s.n.], 2002. http://library.ouhsc.edu/epub/theses/Moore-William-A.pdf.

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França, Isabela Lima 1987. "Técnica de retalho semilunar posicionado coronariamente com ou sem associação à proteína derivada das matriz do esmalte para o tratamento de recessões gengivais : estudo clínico controlado randomizado." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290818.

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Orientador: Enilson Antonio Sallum
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O objetivo deste estudo foi avaliar, clinicamente, a utilização do Retalho Semilunar Posicionado Coronariamente (RSPC) para tratamento de recessões gengivais, com ou sem associação à proteína derivada da matriz do esmalte (EMD). Foram selecionados 30 pacientes, que foram randomizados e alocados em dois grupos: teste (RSPC + EMD) e controle (RSPC sozinho). Para serem incluídos no estudo, os indivíduos deveriam apresentar recessões gengivais vestibulares localizadas classe I de Miller com altura maior ou igual a 2,0mm e menor que 4,0 mm, em caninos ou pré-molares superiores. Parâmetros clínicos avaliados: altura da recessão gengival (ARG), largura da recessão gengival (LRG), nível de inserção clínica (NIC), profundidade de sondagem (PS), altura de tecido queratinizado (ATQ), espessura de tecido queratinizado (ETQ) e altura (AP) e largura (LP) das papilas mesial e distal, além de índice de placa (IPL) e índice gengival (IG). Estes parâmetros foram medidos nos seguintes períodos: baseline, 90 dias e 180 dias após o procedimento cirúrgico. Nenhuma diferença estatisticamente significante foi observada entre os grupos em relação à redução da retração gengival com 6 meses de acompanhamento, embora tenha sido encontrada maior porcentagem de cobertura radicular no grupo RSPC+EMD (91%), quando comparado ao RSPC (87%) (p>0,05). Cobertura radicular completa foi obtida em 60% dos sítios no RSPC enquanto no grupo RSPC+EMD foi observada em 66,67% dos sítios. Dentro dos limites do presente estudo pôde-se concluir que o RSPC, associado ou não a EMD, levou a redução da recessão gengival, sem diferença estatística entre os grupos, após 6 meses de acompanhamento pós-operatório
Abstract: The aim of this study was to evaluate clinically the use of the Semilunar Coronally Positioned Flap (SCPF) for the treatment of gingival recessions, with or without Enamel Matrix Derivative (EMD). Thirty patients were selected, randomized and allocated in two groups: test (SCPF + EMD) and control (SCPF alone). To attend the study, subjects should present buccal Miller class I gingival recessions with height greater than or equal to 2.0 mm and less than to 4.0 mm in maxillary canines or premolars. Clinical parameters evaluated: gingival recession height (GRH), gingival recession width (GRW), clinical attachment level (CAL), probing depth (PD), height (HKT) and thickness (TKT) of keratinized tissue and papillas height (HP) and width (LP), as well as plaque and gingival index. These data were collected at baseline, 90 days and 180 days after surgery. No statistically significant difference was observed between the groups regarding the reduction of gingival recession after 6 months of follow-up, although a higher percentage of root coverage was found in SCPF + EMD group (91%), when compared to the SCPF (87%) (p> 0.05). Complete root coverage was observed in 60% of the sites of the control group (SCPF alone) and in 66,67% of the sites of the test group (SCPF+EMD). Within the limits of this study it was concluded that SCPF, associated or not with EMD may provide a reduction in gingival recession, with no statistical difference between groups
Mestrado
Periodontia
Mestra em Clínica Odontológica
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Mizuno, Hirokazu, Hideaki Kagami, Junji Mase, Daiki Mizuno, and Minoru Ueda. "Efficacy of Membranous Cultured Periosteum for the Treatment of Patients with Severe Periodontitis: a Proof-of-Concept Study." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/12910.

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Ochareon, Pannee. "Craniofacial periosteal cell capacities /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/6387.

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Qasim, Syed Saad B. "Development of novel functionally graded guided tissue regenerative membrane for periodontal lesions." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/11219/.

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Periodontal diseases are chronic inflammatory conditions affecting the supporting tissues of teeth caused by the prolonged accumulation of micro-organisms in the biofilm that forms on tooth surfaces. Conventional non-surgical and surgical treatments aim to halt disease progression and repair the lost periodontal tissues. Surgical therapies such as open flap debridement are aimed to replace the lost alveolar bone and guided tissue regeneration (GTR) is also used to treat this disease. Whilst the regeneration of lost support is an aim of periodontal treatment, the outcomes of current approaches to periodontal regeneration (PR) are unpredictable. Consequently, significant laboratory and clinical research has been undertaken to explore the possibilities of improving the outcomes of treatment over the past few decades. In this respect chitosan (CH), a well-known biopolymer holds promise to be fabricated in various forms. The aim of the project was to fabricate a trilayered functionally graded GTR membrane by fabricating surface and core layers of non-porous and porous morphologies with complete physiochemical and biological characterisation. Solvent Casting, Freeze gelation (FG) and Electrospinning was performed on CH alone and in combination with Hydroxyapatite (HA). Membranes were characterized with Scanning electron Microscopy, Fourier Transform Infrared Spectroscopy (FTIR), tensile testing, long term degradation and swelling studies were also performed. Cell culturing was performed using human osteosarcoma and progenitor cell line. Sirius red and Alizarin red assays were conducted to assess matrix deposition. Amongst the non-porous membranes fabricated by solvent casting, with Low molecular weight (LMw) CH:HA ratio of 30:70 showed better biocompatibility, and amongst the porous membranes made up of FG, ASa (ascorbic acid) :CH:HA (50:50) showed better stability and biocompatibility after in-vitro analysis. Histology of FG membranes conducted after in-vivo studies showed ASa:CH:HA to have higher cellular infiltration after 30 days of implantation. Electrospun fibres obtained in both aligned and random orientations were conducive to cellular attachment and mineralized matrix deposition with time. FTIR analysis showed strong co-ordination bond formation in between CH and HA. HA incorporated samples treated with simulated body fluid (SBF) showed an embryonic layer formation of hydroxyl carbonated apatite. Membranes can be combined together in different ways to achieve structural and functionally graded structures. A template was prepared using solvent casting and freeze gelation techniques to achieve functional gradients. Furthermore; CH and HA composite membranes could possibly be used for GTR applications in periodontal lesions and in addition these techniques could be further tuned to achieve desirable characteristics of a GTR membrane for PR and also holds promise to be used in other biomedical applications.
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Books on the topic "Periodontal Guided Tissue Regeneration"

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Regenerative dentistry. San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA): Morgan & Claypool, 2010.

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Gottlow, Jan. New attachment formation by guided tissue regeneration. Göteborg, Sweden: University of Göteborg, Faculty of Odontology, Dept. of Periodontology, 1986.

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Implant and regenerative therapy. Ames, Iowa: Wiley-Blackwell, 2009.

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Periodontal regeneration enhanced: Clinical applications of enamel matrix proteins. Chicago: Quintessence Pub. Co., 1999.

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Raigrodski, Ariel J. Soft tissue management: The restorative perspective : putting concepts into practice. Chicago: Quintessence Publishing Co, Inc., 2015.

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Dumitrescu, Alexandrina L. Chemicals in Surgical Periodontal Therapy. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2011.

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Debby, Hwang, and Saadoun Andre P, eds. Implant site development. Chichester, West Sussex, UK: Wiley-Blackwell, 2012.

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Dibart, Serge, and Jean-Pierre Dibart. Practical osseous surgery in periodontics and implant dentistry. Chichester, West Sussex, UK: Wiley-Blackwell, 2011.

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Hoffman, Lloyd S. Guided tissue regeneration. [Toronto: Faculty of Dentistry, University of Toronto], 1989.

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Electrospinning for tissue regeneration. Cambridge: Woodhead Pub., 2011.

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Book chapters on the topic "Periodontal Guided Tissue Regeneration"

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Dibart, Serge. "Guided Tissue Regeneration." In Practical Periodontal Plastic Surgery, 65–68. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119014775.ch11.

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Dumitrescu, Alexandrina L. "Guided Tissue Regeneration Barriers." In Chemicals in Surgical Periodontal Therapy, 1–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-18225-9_1.

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Ivanovski, Saso, P. Mark Bartold, Stan Gronthos, and Dietmar W. Hutmacher. "Periodontal tissue engineering." In Tissue Engineering and Regeneration in Dentistry, 124–44. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781119282181.ch7.

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Iranparvar, Aysel, Amin Nozariasbmarz, Sara DeGrave, and Lobat Tayebi. "Tissue Engineering in Periodontal Regeneration." In Applications of Biomedical Engineering in Dentistry, 301–27. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21583-5_14.

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Rath, Avita, Preena Sidhu, Priyadarshini Hesarghatta Ramamurthy, Bennete Aloysius Fernandesv, Swapnil Shankargouda, and Sultan Orner Sheriff. "Gingiva and Periodontal Tissue Regeneration." In Current Advances in Oral and Craniofacial Tissue Engineering, 139–58. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429423055-10.

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Llamosa-Cáñez, Lizette. "Microsurgery in Guided Bone Regeneration." In Microsurgery in Periodontal and Implant Dentistry, 373–444. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-96874-8_11.

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Dumitrescu, Alexandrina L. "Enamel Matrix Derivative for Periodontal Tissue Regeneration." In Chemicals in Surgical Periodontal Therapy, 145–215. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-18225-9_3.

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Tanaka, Eiji, Toshihiro Inubushi, and Tarek El-Bialy. "Application of LIPUS to Periodontal Tissue Regeneration." In Therapeutic Ultrasound in Dentistry, 35–42. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-66323-4_5.

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Guess, Garrett, and Samuel Kratchman. "Guided Tissue Regeneration in Endodontic Microsurgery." In Microsurgery in Endodontics, 193–203. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119412502.ch19.

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Niemiec, Brook A., and Robert Furman. "Osseous Surgery and Guided Tissue Regeneration." In Veterinary Periodontology, 254–88. West Sussex, UK: John Wiley & Sons, Inc,., 2013. http://dx.doi.org/10.1002/9781118705018.ch18.

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Conference papers on the topic "Periodontal Guided Tissue Regeneration"

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Setyawati, Ernie Maduratna, and Nahdhiya Amalia Puspita Klana. "Concise review: Periodontal tissue regeneration using pericardium membrane as guided bone regeneration." In THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0036635.

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Unrau, Bernard. "GT (Guided Tissue Regeneration) Incorporating a Modified Microgravity Surgical Chamber and Kavo-3-Mini Unit for the Treatment of Advanced Periodontal Disease Encountered in Extended Space Missions." In International Conference On Environmental Systems. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1991. http://dx.doi.org/10.4271/911337.

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Qasim, S. B., R. Delaine-Smith, A. Rawlinson, and I. U. Rehman. "Development of a Novel Bioactive Functionally Guided Tissue Graded Membrane for Periodontal Lesions." In University of Sheffield Engineering Symposium. USES, 2015. http://dx.doi.org/10.15445/01012014.07.

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Shyh Ming Kuo, Shwu Jen Chang, Yun Ting Hsu, and Ta Wei Chen. "Evaluation of Alginate coated Chitosan Membrane for Guided Tissue Regeneration." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1615565.

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Ishii, Katsunori, Zhenhe Ma, Yoshihisa Ninomiya, Minori Takegoshi, Toshihiro Kushibiki, Masaya Yamamoto, Monica Hinds, Yasuhiko Tabata, Ruikang K. Wang, and Kunio Awazu. "Control of guided hard-tissue regeneration using phosphorylated gelatin and OCT imaging of calcification." In Biomedical Optics (BiOS) 2007, edited by Sean J. Kirkpatrick and Ruikang K. Wang. SPIE, 2007. http://dx.doi.org/10.1117/12.701485.

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Rossmann, Jeffrey A., Ates Parlar, Khaled A. Abdel-Ghaffar, Amr M. El-Khouli, and Michael Israel. "Use of the carbon dioxide laser in guided tissue regeneration wound healing in the beagle dog." In Photonics West '96, edited by Harvey A. Wigdor, John D. B. Featherstone, Joel M. White, and Joseph Neev. SPIE, 1996. http://dx.doi.org/10.1117/12.238753.

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Andriani, Ika, Atiek Driana Rahmawati, Maulida Nurhasanah, and M. Ihza Humanindito. "The Effects of Antimicrobial Peptide Gel on Angiogenesis and Fibroblast Cells in Periodontal Tissue Regeneration in a Periodontitis Rats Model Exposed by Nicotine." In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.210115.036.

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Krishnamoorthy, Srikumar, and Changxue Xu. "Fabrication of a Graded Micropillar Surface for Guided Cell Migration." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8332.

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Abstract The migration of cells is caused by the interaction of cells and the local microenvironment around them, such as changes in stiffness, chemical gradients etc. The local topography of substrates in contact with cells is a key factor that regulates the migration of cells. The interaction between the topography of the substrate and cells is crucial for the understanding of tissue development and regeneration. In this paper, the fabrication of a graded micropillar substrate for studying topography-based cell migration is described in detail. The fabrication protocol comprises of the utilization of dynamic maskless lithography system, capillary molding, and corona arc surface treatment. The fabricated micropillar substrate has been shown and the cells have been successfully seeded on the substrate. Guided cell migration on the substrate with graded microtopography has been demonstrated to occur from the sparser zone to the denser zone. Moreover, some examples of potential applications are provided.
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Cheng, Yu-Chen, and Pen-Hsiu Grace Chao. "A Model for Ligament Fibroblast Migration Into Provisional Matrix." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53858.

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Many strategies have been proposed to enhance the healing capability of the anterior cruciate ligament (ACL). A novel treatment option, called enhanced primary repair, places a provisional matrix at the tear site to promote cell infiltration of the wound and aims to reestablish the structure-function relationship of the ACL [1]. This approach of guided tissue regeneration offers great potential benefits of retaining the complex native tissue matrix structure, innervation, and vascularization as compared with grafts. A major aspect of this procedure is enhancing ligament fibroblast infiltration into the matrix material and promoting matrix synthesis. We have previously demonstrated that applied electric fields (EFs) enhance knee ligament fibroblast migration, alignment, and collagen gene expressions on planar substrates [2]. In the current study, we developed a new system to simulate cell infiltration from the tissue to a provisional collagen matrix. An EF was applied across the construct to investigate its effects of on ACL fibroblast migration into the provisional matrix.
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Wettergreen, M., B. Bucklen, B. Starly, E. Yuksel, W. Sun, and M. A. K. Liebschner. "Unit Block Library of Basic Architectures for Use in Computer-Aided Tissue Engineering of Bone Replacement Scaffolds." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81984.

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Guided tissue regeneration focuses on the implantation of a scaffold architecture, which acts as a conduit for stimulated tissue growth. Successful scaffolds must fulfill three basic requirements: provide architecture conducive to cell attachment, support adequate fluid perfusion, and provide mechanical stability during healing and degradation. The first two of these concerns have been addressed successfully with standard scaffold fabrication techniques. In instances where load bearing implants are required, such as in treatment of the spine and long bones, application of these normal design criteria is not always feasible. The scaffold may support tissue invasion and fluid perfusion but with insufficient mechanical stability, likely collapsing after implantation as a result of the contradictory nature of the design factors involved. Addressing mechanical stability of a resorbable implant requires specific control over the scaffold design. With design and manufacturing advancements, such as rapid prototyping and other fabrication methods, research has shifted towards the optimization of scaffolds with both global mechanical properties matching native tissue, and micro-structural dimensions tailored to a site-specific defect. While previous research has demonstrated the ability to create architectures of repetitious microstructures and characterize them, the ideal implant is one that would readily be assembled in series or parallel, each location corresponding to specific mechanical and perfusion properties. The goal of this study was to design a library of implantable micro-structures (unit blocks) which may be combined piecewise, and seamlessly integrated, according to their mechanical function. Once a library of micro-structures is created, a material may be selected through interpolation to obtain the desired mechanical properties and porosity. Our study incorporated a linear, isotropic, finite element analysis on a series of various micro-structures to determine their material properties over a wide range of porosities. Furthermore, an analysis of the stress profile throughout the unit blocks was conducted to investigate the effect of the spatial distribution of the building material. Computer Aided Design (CAD) and Finite Element Analysis (FEA) hybridized with manufacturing techniques such as Solid Freeform Fabrication (SFF), is hypothesized to allow for virtual design, characterization, and production of scaffolds optimized for tissue replacement. This procedure will allow a tissue engineering approach to focus solely on the role of architectural selection by combining symmetric scaffold micro-structures in an anti-symmetric or anisotropic manner as needed. The methodology is discussed in the sphere of bone regeneration, and examples of cataloged shapes are presented. Similar principles may apply for other organs as well.
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