Relevant bibliographies by topics / Perimenopause

Academic literature on the topic 'Perimenopause'

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Published: 4 June 2021
Last updated: 3 March 2023

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Journal articles on the topic "Perimenopause"

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Anggraeni, Novi. "PENGARUH PENGGUNAAN KONTRASEPSI HORMONAL TERHADAP KELUHAN PERIMENOPAUSE PADA WANITA USIA 45-49 TAHUN DIWILAYAH KERJA UPT PUSKESMAS KLAMPIS KABUPATEN BANGKALAN." JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 10, no. 1 (November 27, 2019): 54–62. http://dx.doi.org/10.36089/job.v1i1.75.

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Perimenopause is the transition between pre menopausal and postmenopausal. This transition occur sin women aged 45-55 years as aresul to fade crease in sex hormones, namely estrogen and progesterone. As a result of the hormone efficiency appears to complaints called perimenopause complaints that are affected by the use of hormonal contraceptives. Yield data of women aged 45-49 years who use hormonal contraceptives as many as 60 people and are non-hormonal many as 14 people (40%). The purpose of this study was to analyze the influence of hormonal contraceptive use on the complaint perimenopausal women aged 45-49 years in there gion of UPT Puskesmas Klampis Bangkalan. There search design was across sectional, population all mothers aged 45-49 whouse contraceptives as many as 74 people with simple random sampling technique. The independent variables namely the use of contraceptives and the dependent variable is the complaint of perimenopause. Methods of data collection using the questionnaire translated into a frequency distribution ableand narrative, analyzed by statistical test Chi Square with a significance level(α) =0.05 The study of 62 respondents, nearly all mothers are using hormonal contraception (83.9%) and the majority of complaints perimenopause mother is no complaints (67.7%). Complaints perimenopaus al women after use of hormonal contraceptionis almost entirely no complaints easily tired than when we were younger. Statistics Chi Square tests how edthat there is the influence of hormonal contraceptive use on the complaint of perimenopause=0,000. Women should need openness to many health workers ask about the problems of menopause are expected mothers can live a good life with and without interfering with daily activities.
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Soares, Cláudio de Novaes, and Lee Stuart Cohen. "The perimenopause, depressive disorders, and hormonal variability." Sao Paulo Medical Journal 119, no. 2 (March 2001): 78–83. http://dx.doi.org/10.1590/s1516-31802001000200008.

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CONTEXT: Several investigations have postulated that the perimenopause may represent a period of increased psychiatric vulnerability, particularly for mood disorders. This review characterizes the perimenopause, including biological changes, the influence of psychosocial factors and the most common clinical manifestations. Clinic-based studies and community-based surveys addressing the prevalence of depressive symptoms in perimenopausal women are critically reviewed. We also discuss the potential greater vulnerability to mood disturbance during the perimenopause in response to hormonal variability. A therapeutic algorithm for management of depressive symptoms in middle-aged perimenopausal women is also presented. The role of estrogen in the treatment of perimenopausal depressive symptoms is particularly discussed. In addition, we review the existing data regarding the potential efficacy of estrogen as an antidepressant agent (monotherapy, augmentation strategy or prophylaxis). DESIGN: Narrative review.
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Soares, Cláudio N., and Lee S. Cohen. "Perimenopause and Mood Disturbance: An Update." CNS Spectrums 6, no. 2 (February 2001): 167–74. http://dx.doi.org/10.1017/s1092852900007926.

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AbstractThis review characterizes perimenopause, including biologic changes, the influence of psychosocial factors, and the most common clinical manifestations. Clinic-based studies and community-based surveys addressing the prevalence of depressive symptoms in perimenopausal women are critically reviewed. Also discussed is the potentially greater vulnerability to mood disturbance during perimenopause in response to hormonal variability. A therapeutic algorithm for management of depressive symptoms in middle-aged perimenopausal women is presented. The role of estrogen in the treatment of perimenopausal depressive symptoms is addressed. In addition, the article contains a review of the existing data on the potential efficacy of estrogen as an antidepressant agent (monotherapy, augmentation strategy, or prophylaxis).
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Asih, Ni Wayan Dewi Putriny, Cokorda Bagus Jaya Lesmana, Anak Ayu Sri Wahyuni, Ni Ketut Sri Diniari, and Luh Nyoman Alit Aryani. "Correlation between perimenopausal syndromes and depression in nurses at Sanglah General Hospital." Journal of Clinical and Cultural Psychiatry 1, no. 1 (March 2, 2020): 14–17. http://dx.doi.org/10.36444/vii1.008.

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Background: Perimenopause covers the period immediately before the menopause and the first year after the last menstrual period. In addition to the changes in the menstrual cycle, women in the perimenopause phase often report a number of perimenopausal complaints and depressive disorders. This study aims to determine the prevalence of perimenopausal complaints and depression experienced in nurses at Sanglah General Hospital. Methods: The study uses a cross-sectional analytical. The measurement of perimenopause complaints uses the Menopause Rating Scale (MRS) questionnaire and the depression measurement uses the Beck Depression Inventory-II questionnaire (BDI-II). The data are analyzed descriptively, it uses the Fisher test and linear regression test with significance level p <0.05. Results: Nurses who have perimenopausal complaints are 62.7%. Besides, depression is experienced by 23.8% of nurses who have perimenopausal complaints. The complained somatic symptoms with a mild degree are 50% and moderate degree is 40%. While the urogenital sexual symptoms with a moderate degree are 60%, and mild and severe degrees are 20%. Conclusion: This study shows the relationship between perimenopausal complaints and the depression of the nurses in Sanglah General Hospital. Therefore, it is necessary to hold an early detection of depression prevention by screening perimenopausal complaints.
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Bhakta, Amita, Harold Esseku, Yvonne Esseku, Julie Fisher, and Brian Reed. "The hidden WASH needs of perimenopausal women." Journal of Water, Sanitation and Hygiene for Development 11, no. 6 (October 5, 2021): 1016–25. http://dx.doi.org/10.2166/washdev.2021.101.

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Abstract Meeting the needs of an ageing population, particularly in the global South, is increasingly an issue for WASH service provision. An ageing-related issue for women, warranting specific attention from the WASH sector, is the perimenopause, but this is often not discussed publicly. Drawing on data from the UK and Ghana, this paper provides recommendations for meeting the additional WASH needs of women as they experience the perimenopause (the transition period to menopause). Finding these ‘hidden’ needs involved a UK-based phenomenological review and mixed feminist methods in two low-income urban communities in Accra and Kumasi, Ghana. The hidden WASH needs of perimenopausal women included understanding the perimenopause, menstrual hygiene management, urine incontinence management, bathing, and laundry. Community awareness, engagement and empowerment, and ensuring good perimenopausal health can begin to address these needs. Infrastructural measures for perimenopausal women include a continuous water supply, user-friendly bathing and laundry infrastructure, and gender-sensitive, accessible toilets with discrete sanitary disposal bins. High-absorbency sanitary products are important for managing heavy menstruation. A better understanding of the needs of perimenopausal women and training on how to meet these would benefit the WASH sector in ensuring that perimenopausal women are not left behind in efforts to meet the Sustainable Development Goals.
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Bhakta, Amita, Harold Esseku, Yvonne Esseku, Julie Fisher, and Brian Reed. "The hidden WASH needs of perimenopausal women." Journal of Water, Sanitation and Hygiene for Development 11, no. 6 (October 5, 2021): 1016–25. http://dx.doi.org/10.2166/washdev.2021.101.

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Abstract Meeting the needs of an ageing population, particularly in the global South, is increasingly an issue for WASH service provision. An ageing-related issue for women, warranting specific attention from the WASH sector, is the perimenopause, but this is often not discussed publicly. Drawing on data from the UK and Ghana, this paper provides recommendations for meeting the additional WASH needs of women as they experience the perimenopause (the transition period to menopause). Finding these ‘hidden’ needs involved a UK-based phenomenological review and mixed feminist methods in two low-income urban communities in Accra and Kumasi, Ghana. The hidden WASH needs of perimenopausal women included understanding the perimenopause, menstrual hygiene management, urine incontinence management, bathing, and laundry. Community awareness, engagement and empowerment, and ensuring good perimenopausal health can begin to address these needs. Infrastructural measures for perimenopausal women include a continuous water supply, user-friendly bathing and laundry infrastructure, and gender-sensitive, accessible toilets with discrete sanitary disposal bins. High-absorbency sanitary products are important for managing heavy menstruation. A better understanding of the needs of perimenopausal women and training on how to meet these would benefit the WASH sector in ensuring that perimenopausal women are not left behind in efforts to meet the Sustainable Development Goals.
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Nuraeni, Nuraeni, Imas Kania Rahman, and Budi Handrianto. "Kesadaran Religiusitas Orang Dewasa sebagai Solusi bagi Sindrom Perimenopause Menurut Zakiyah Darajat." NUKHBATUL 'ULUM: Jurnal Bidang Kajian Islam 8, no. 2 (December 12, 2022): 108–24. http://dx.doi.org/10.36701/nukhbah.v8i2.563.

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This research discusses perimenopause, which is the period leading up to menopause. This period is the final stage of the biological process experienced by women, where at this time there are various changes both in terms of physical, and psychological. This research aims to provide a solution to the discomfort felt by perimenopause women who actually need help, both by themselves and their environment, with their religious knowledge. This paper uses qualitative methods with this type of literature and field research. The results showed that the situation in the tumultuous perimenopause period, can only be faced by getting close to Allah ﷻ, therefore a perimenopausal woman must further deepen her religious knowledge. The religious knowledge possessed by a perimenopause woman will automatically help fortify her to deal with the turmoil of perimenopause accompanied by the full support of family and the environment. The authors hope that this study can give color to the study of Islamic counseling guidance for adults with cases of perimenopause, and contribute information about all matters related to the perimenopause period to government and private institutions and the wider community so that the resilience of Muslim households can be maintained in the context of feel Calm, love and affection.
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Kaur, Harshiba, and Neerja Goel. "Comparative evaluation of menstrual patterns and hormonal profiles in normal and abnormal perimenopause." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 9 (August 26, 2019): 3556. http://dx.doi.org/10.18203/2320-1770.ijrcog20193775.

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Background: Currently there is only one marker to objectively establish perimenopause ie menstrual irregularities. Due to the wide variation in hormones like LH, FSH, estradiol, they become unreliable in predicting approaching menopause. This study was conducted to study and compare the patterns of LH, FSH and Estradiol in normal and abnormal perimenopause using the Stages of Reproductive Ageing Workshop (STRAW) criteria.Methods: A comparative evaluation was done after enrolling 200 patients out of which 100 women were in normal perimenopause (early-25 and late perimenopause-75, depending upon menstrual characteristics as defined by STRAW criteria) and 100 having AUB. Sociodemographic data, presence of menopausal symptoms were recorded. S. LH, S.FSH and S. estradiol we determined by adapted solid phase direct sandwich ELISA.Results: FSH was in menopausal ranges (>20IU/L) in early and late perimenopause. LH and FSH in women with AUB ranged from pre to post menopausal ranges. There was significant difference in LH and FSH between normal perimenopause and abnormal uterine bleeding. Estradiol levels showed a significant difference between late perimenopause and AUB p=0.015.Conclusions: This study shows that there is a progressive incremental trend in FSH and LH and decremental trend in Estradiol from early to late perimenopause due to decrease in ovarian follicular reserve, although the difference is not significant. Clinical symptoms present in 50% of late perimenopausal women showed that besides menstrual characteristics we can correlate these menopausal symptoms with raised FSH and low Estradiol. These women can be picked up and preventive therapy may be provided.
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Nguyen, Thao Thi Phuong, Hai Thanh Phan, Thuc Minh Thi Vu, Phuc Quang Tran, Hieu Trung Do, Linh Gia Vu, Linh Phuong Doan, et al. "Physical activity and social support are associated with quality of life in middle-aged women." PLOS ONE 17, no. 5 (May 6, 2022): e0268135. http://dx.doi.org/10.1371/journal.pone.0268135.

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Purposes This cross-sectional study assessed the quality of life and related factors of Vietnamese women during perimenopause in terms of vasomotor, psychosocial, physical, and sexual aspects. Materials and methods A cross-sectional study on 400 middle-aged women was conducted in Hung Yen, a delta province in Vietnam. Data about socioeconomic characteristics, daily activity patterns, quality of life in terms of vasomotor, psychosocial, physical, and sexual aspects, and level of social support were collected. Tobit multivariate regression model was used to identify factors related to the quality of life among participants. Results The symptoms of perimenopause appeared to worsen with the increase of age and the existence of such health issues as migraine and diabetes. Meanwhile, exercises, recreational activities, and social support appeared to alleviate the negative impact of perimenopausal symptoms on women. Conclusions It is important to address the care needs of women during perimenopausal age, especially their sexual well-being, and development of specific healthcare services and programs focusing on sport, entertainment, and support for women in perimenopause should be facilitated.
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Li, Rui-xia, Min Ma, Xi-rong Xiao, Yan Xu, Xiu-ying Chen, and Bin Li. "Perimenopausal syndrome and mood disorders in perimenopause." Medicine 95, no. 32 (August 2016): e4466. http://dx.doi.org/10.1097/md.0000000000004466.

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Dissertations / Theses on the topic "Perimenopause"

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McChlery, Sheena Maureen. "Women’s experiences of perimenopause." Thesis, McChlery, Sheena Maureen (2021) Women’s experiences of perimenopause. PhD thesis, Murdoch University, 2021. https://researchrepository.murdoch.edu.au/id/eprint/62728/.

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Every woman, if she lives long enough, will experience perimenopause, the time period leading up to menopause when hormonal changes often cause physical, and sometimes emotional, changes. Whilst menopause has been extensively investigated perimenopause has received little attention and much of the existing research has been conducted by health professionals, with often only a narrow focus. In addition, the experience of women living through perimenopause is largely missing. Knowledge of such experiences can assist in understanding the meaning that perimenopause has for women, and can also assist in providing insight into the effectiveness of current models of care and management. The aim of this study was to explore the experiences of Western Australian women living through perimenopause. A phenomenological approach, specifically, van Manen’s human sciences (2017) and phenomenology of practice (2014) approaches, were used to collect and analyse qualitative data from eighteen women. van Manen’s (2017) four existentials, namely corporeality, temporality, spatiality and relationality, were used as a reflective lens during the exploration and organisation of the data, resulting in the generation of themes within the four lifeworld existentials. A feminist framework also guided development of the research design and feminist theories, along with Leder’s (1990) essay on the absent body in everyday life, provided support for the discussion of the findings. The women described their perimenopausal experiences in terms of challenges, and in terms of agency. Challenges related to the body, the environment, and the attitudes of spouses and other family members. The attitude and care provision of medical doctors was also viewed as a challenge by many women. However, the women demonstrated agency by finding alternative sources of care and ways of coping with their symptoms, by drawing on their mothers’ experiences to improve their own, and by seeking valuable friendships in which to safely discuss perimenopause. The stories of the women demonstrated that the current medical model of care and management does not fit the needs of contemporary perimenopausal women. There is also a general lack of experiential information about perimenopause, and this has resulted in an incomplete and incorrect picture of perimenopause. In addition, adequate support structures for perimenopausal women are missing. Women demonstrate agency, however, by seeking alternative support structures and driving their own changes to improve their midlife health.
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Mosconi, Lisa, Valentina Berti, Crystal Guyara-Quinn, Pauline McHugh, Gabriella Petrongolo, Ricardo S. Osorio, Christopher Connaughty, et al. "Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/626072.

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After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estrogenic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause. This is evident in glucose hypometabolism and decline in mitochondrial efficiency which is sustained thereafter. This study bridges basic to clinical science to characterize brain bioenergetics in a cohort of forty-three, 40-60 year-old clinically and cognitively normal women at different endocrine transition stages including premenopause (controls, CNT, n = 15), perimenopause (PERI, n = 14) and postmenopause (MENO, n = 14). All participants received clinical, laboratory and neuropsychological examinations, F-18-fluoro-deoxyglucose (FDG)Positron Emission Tomography (PET) FDG-PET scans to estimate CMRglc, and platelet mitochondrial cytochrome oxidase (COX) activity measures. Statistical parametric mapping and multiple regression models were used to examine clinical, CMRglc and COX data across groups. As expected, the MENO group was older than PERI and controls. Groups were otherwise comparable for clinical measures and distribution of APOE4 genotype. Both MENO and PERI groups exhibited reduced CMRglc in AD-vulnerable regions which was correlated with decline in mitochondrial COX activity compared to CNT (p's<0.001). A gradient in biomarker abnormalities was most pronounced in MENO, intermediate in PERI, and lowest in CNT (p<0.001). Biomarkers correlated with immediate and delayed memory scores (Pearson's 0.26 <= r <= 0.32, p <= 0.05). These findings validate earlier preclinical findings and indicate emergence of bioenergetic deficits in perimenopausal and postmenopausal women, suggesting that the optimal window of opportunity for therapeutic intervention in women is early in the endocrine aging process.
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Portella, Caio Fábio Schlechta. "Qualidade de vida e insônia na perimenopausa: meditação como estratégia de intervenção." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/6/6136/tde-09042014-104755/.

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Introdução: A insônia está entre os mais frequentes transtornos que afetam a população na contemporaneidade, devido a mudanças hormonais e psicossociais importantes é muito prevalente na perimenopausa. Há uma relação ainda pouco estudada entre eficiência do sono e prática meditativa. Os tratamentos utilizados para insônia normalmente são de alto custo e paliativos. Objetivo: Avaliar o efeito da meditação na insônia (causada por sintomas característicos da perimenopausa) e qualidade de vida nesta fase da vida. Método: Ensaio clínico controlado para avaliar os efeitos da meditação em mulheres com insônia no período da perimenopausa e o impacto na qualidade de vida em 8 semanas de intervenção. O estudo foi realizado de abril a julho de 2013 com 33 mulheres na perimenopausa de idade entre 40 a 55 anos em 3 unidades de órgão público no município de São Paulo, SP. As participantes foram divididas aleatoriamente em dois grupos, um que praticou somente Higiene do Sono-HS (n=15) e outro que praticou Meditação + Higiene do Sono-M+HS (n=18). Foram realizados encontros semanais com as participantes de ambos os grupos para pratica de meditação em grupo e/ou critérios de higiene do sono. O grupo M+HS também realizou prática diária de meditação. Para avaliar a significância estatística das diferenças de médias antes e depois das intervenções em cada grupo foi utilizado o teste de Wilcoxon. Resultados: Houve melhora da insônia em ambos os grupos, no entanto comparando as diferenças de escore do Índice de Gravidade de Insônia entre os grupos estudados, o grupo M+HS teve um efeito superior em ambas as medições em relação ao grupos HS. No grupo M+HS, houve redução estatisticamente significativa nas categorias do Índice Menopausal de Kupperman: Palpitação, Parestesia e a Pontuação Total já no grupo HS não houve redução significativa em nenhum parâmetro do Índice de Kupperman. Houve melhora significativa da pontuação geral de qualidade de vida aferida pelo WHOQOL breve no grupo M +HS, e no grupo HS houve melhora no domínio relações sociais. Conclusão: Os resultados sugerem que a meditação pode ser ferramenta útil no tratamento da insônia primária durante o período da perimenopausa. A qualidade de vida durante este período também é favorecida de maneira global pela prática diária de meditação.
Introduction: Insomnia is one of the most common disorders that affect the population in contemporaneity, because of important hormonal and psychosocial changes is very prevalent in perimenopause. There is a still understudied relationship between sleep efficiency and meditative practice. The treatments for insomnia are usually expensive and palliative. Objective: Evaluate the effects of meditation in insomnia (caused by typical symptoms of perimenopause) and quality of life in this phase of life. Method: controlled clinical trial to evaluate the effects of meditation in women with insomnia during perimenopause and impact on quality of life in 8-week intervention. The study was conducted from April to July 2013 with 33 perimenopausal women aged between 40-55 years in 3 units of public organization in São Paulo, SP, Brazil. The participants were randomly assigned to two groups, one who performed only Sleep Hygiene-HS (n = 15) and another who performed Meditation + Sleep Hygiene - SH + M (n = 18). Weekly meetings were held with the participants of both groups to practice meditation in a group and / or criteria for the sleep hygiene. The M + SH group also performed daily meditation practice. To assess the statistical significance of differences in means before and after the interventions in each group, the Wilcoxon test was applied. Results: Improvement of sleep quality in both groups, however comparing the differences in the scores of the Insomnia Severity Index between groups, group M + SH had a greater effect on both measures compared to the SH group. In M + SH group showed a statistically significant reduction in the categories of the Kupperman Menopausal Index: palpitations, paresthesia and Total Score, already in the SH group there was no significant reduction in any parameter of the Kupperman Index. A Significant improvement in overall quality of life (measured by WHOQOL-brief) score in group M + HS, and HS group had improvement in social relationships domain. Conclusion: The results suggest that meditation can be useful tool in the treatment of primary insomnia during the perimenopause. The quality of life during this period is also favored globally by daily meditation practice.
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Freire, Neto Francisco Paulo. "Influ?ncia do tratamento com ?cido lipoico sobre o metabolismo ?sseo e perfil antioxidante de mulheres na perimenopausa." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13472.

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Bone is a dynamic tissue that is in constant process of remodeling in response to mechanical stress and hormonal changes. This study aimed to understand the relationship between the biochemical changes, which women in the menopausal transition are subject to, and how the use of an alternative therapy with lipoic acid (LA) could influence these changes. The study of double-blind, was carried out in perimenopausal women that underwent a three month treatment with 600 mg of AL compared with another group that received placebo during the same period. This study showed that women had a waist circunference and body mass index above the values recommended by WHO (WC ≥ 80 cm; BMI > 25kg/m2). Associated with this, these women had increased concentrations of total cholesterol and triglycerides, and borderline LDL (Total Cholesterol > 200mg/dL; Triglycerides > 150mg/dL; LDL >130mg/dL). These changes were not affected by treatment with AL. There were no shifts in liver profile (ALT, AST and GGT), kidney profile (urea, creatinine, total protein and albumin), mineral profile (Total Calcium, Ionized Calcium, Phosphorus and Magnesium) as well in bone markers (osteocalcin, Total Alkaline Phosphatase and Tartrate Resistant Acid Phosphatase) after treatment with LA. The results of the oxidative profile showed that treatment with LA decreased GPx activity (p < 0,01), while for the TBARS, GSH and SOD activity there were no differences. With regard to SOD, this enzyme will submit to be high in the placebo group after 3 months of study (p<0,05). The expression of RANKL mRNA was reduced (p < 0,05) and of RANK increased (p <0.001), after treatment with LA, while the expression of IL-6 and TNF-ɑ genes were no changed. We conclude that women already in the perimenopause stage have changes in lipid profile and body composition that could induce shifts in oxidative and bone metabolism. However, LA treatment has provided an effective effect in the oxidative and bone profile since the earliest markers such as GPx activity and mRNA expression of RANKL, respectively, were reduced associated with no change in SOD activity. These results suggest a beneficial and protective effect of LA, indicating it potential as an alternative treatment to help the to prevent the complications associated with estrogen deficiency
O osso ? um tecido din?mico que est? em constante processo de remodela??o em resposta ao estresse mec?nico e mudan?as hormonais. O presente trabalho teve por objetivo entender a rela??o entre as altera??es bioqu?micas, oxidativas e moleculares em mulheres em transi??o menopausal e a influ?ncia do uso do ?cido lipoico (AL) nessas altera??es. O estudo do tipo duplo-cego, foi realizado com mulheres em perimenopausa submetidas ? um tratamento de 3 meses com 600 mg de AL administrados por via oral em duas doses di?rias, comparadas com um outro grupo que recebeu placebo durante o mesmo per?odo. O presente trabalho mostrou que as mulheres apresentaram uma circunfer?ncia de cintura (CC) e um ?ndice de massa corporal, em m?dia, acima dos valores preconizados pela OMS (CC ≥ 80 cm; IMC > 25kg/m2). Al?m disso, essas mulheres apresentaram aumento nas concentra??es de colesterol total e triglicer?deos, al?m de valores de LDL pr?ximos do lim?trofe (Colesterol Total > 200mg/dL; Triglicer?deos > 150mg/dL; LDL >130mg/dL). Essas altera??es n?o sofreram influ?ncia do tratamento com AL. N?o foram encontradas altera??es no perfil hep?tico (ALT, AST e GGT) e renal (Ur?ia, Creatinina, Prote?nas Totais e Albumina) das mulheres ap?s o tratamento com AL, bem como no perfil mineral (C?lcio Total, C?lcio Ionizado, F?sforo e Magn?sio) e ?sseo (Osteocalcina, Fosfatase Alcalina Total e Fosfatase ?cida Tartarato Resistente). Os resultados do perfil oxidativo mostraram que o tratamento com AL diminuiu a atividade da enzim?tica da Glutationa Peroxidase (GPx) (p <0,01), enquanto para os par?metros Subst?ncias Reativas ao ?cido Tiobarbit?ricos (SRAT s), Glutationa Reduzida (GSH) e Super?xido Dismutase (SOD) n?o houve diferen?as. A SOD apesentou-se elevada no grupo placebo ap?s os 3 meses de estudo (p<0,05). A express?o do mRNA do RANKL em leuc?citos totais mostrou-se diminu?da (p < 0,05) e do RANK aumentada (p<0,001), ap?s o tratamento com AL, enquanto a express?o dos genes IL-6 e TNF-ɑ n?o apresentou altera??o. Podemos concluir que as mulheres em est?gio de perimenopausa, inicial de defici?ncia estrog?nica, apresentam altera??o no perfil lip?dico e composi??o corporal, e que essas altera??es poderiam estar induzindo altera??es no perfil oxidativo e do metabolismo ?sseo. Entretanto, o tratamento com AL se mostrou eficaz para o perfil oxidativo, bem como ?sseo j? que marcadores precoces como a atividade da GPx e a express?o do mRNA do RANKL, respectivamente, foram reduzidos associada a n?o altera??o na atividade da SOD. Estes resultados sugerem o efeito ben?fico e protetor do AL, indicando-o como uma alternativa para tratamento auxiliar nas complica??es associadas ? defici?ncia estrog?nica
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Morgan, Patricia Ann. "Women's perceptions of midlife mothering during perimenopause : the impact on health and well-being through life's transitions." Thesis, Swansea University, 2010. https://cronfa.swan.ac.uk/Record/cronfa42771.

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The aim of this research was to understand women's perceptions of their health as they mothered young children while simultaneously transitioning to menopause. This inquiry was inspired by the growing demographics for 'older first-time mothers', which create a unique phenomenon in which the developmental transition to motherhood is followed closely or overlapped by the biological transition to menopause/perimenopause. A gap in knowledge about the unique experiences of first time mothers aged forty and older during perimenopause, invited study. The researcher conducted a hermeneutic, phenomenological interpretation of the lived experiences of the older first-time mothers who participated in this study. This v/as accomplished through two in-depth interviews with thirteen women aged 39-47 when they achieved motherhood, and 45-56 years old at the time of the interviews. Gadamer's (1975/2004b) philosophical underpinnings guided this study, and meaning was mutually negotiated through participative dialogue with the participants and simultaneously with the text. Van Manen's (1990) six methodological themes guided ongoing construction and analysis of data. The findings led to an historical and contextual understanding of women's experiences during this time of overlapping transitions, and four main themes emerged: Achieving First-Time Motherhood at Midlife, Intensive Mothering, Out of Sync, and Perimenopause as a State of Uncertainty. Despite a negative appraisal of perimenopause, an uncertain temporality, projection of the life span, and value of health as precious enabled the women to transform uncertainty into opportunities for health promotion. The findings from this inquiry contribute new knowledge for nurses and other health care providers about the meaning of health and mothering for older first time mothers during perimenopause. Findings from this study which have captured women's experiences enable health care providers to refocus or recalibrate the frameworks and norms traditionally applied to first- time midlife mothers, and improve the care they provide for women during perimenopause.
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Oliveira, Nayara Pestana de. "Efeitos da terapia estrogênica sobre a neuroquímica de fêmeas em modelo animal de perimenopausa (rata) induzida pelo 4-diepóxido de vinilciclohexano." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-23072018-104343/.

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A perimenopausa representa a transição da vida reprodutiva para não reprodutiva. É geralmente caracterizada por alterações neuroendócrinas, metabólicas e comportamentais, um possível resultado da depleção folicular ovariana e consequente redução do número de folículos ovarianos. É o período em que as mulheres podem apresentar maior susceptibilidade a manifestar transtornos afetivos e de ansiedade. A exposição de roedores ao resíduo químico 4-diepóxido de vinilciclohexeno (VCD) é um modelo bem estabelecido para estudos sobre perimenopausa, pois o VCD acelera o processo natural de atresia folicular. Embora as concentrações plasmáticas de estradiol estejam normais ou elevadas durante a perimenopausa, a terapia com estradiol pode ser benéfica para mulheres sintomáticas na perimenopausa. Portanto, o objetivo do presente trabalho foi investigar se a depleção folicular gradativa acelerada pelo VCD resulta em alterações na neuroquímica de ratas fêmeas em núcleos cerebrais que controlam o humor, além de avaliar se o estradiol seria capaz de reverter as possíveis alterações. Ratas da linhagem Wistar (28 dias pós-natal) receberam diariamente, durante 15 dias consecutivos, injeções subcutâneas de VCD (160 mg / kg) ou óleo de milho (O). Aproximadamente 55 dias após a primeira injeção, cápsulas de silastic contendo 17?-estradiol (E) ou O foram inseridas subcutaneamente (Grupos O+O; VCD+O; VCD+E). Cerca de 21 dias após o implante das cápsulas, as ratas dos grupos O+O e VCD+O foram decapitadas na manhã do diestro, enquanto que as do grupo VCD+E foram decapitadas exatamente 21 dias após o implante das cápsulas contendo estradiol, entre 0900 h e 1100 h. O sangue foi colhido para avaliação das concentrações plasmáticas de estradiol e progesterona por radioimunoensaio (RIE). Os cérebros foram removidos para microdissecção do hipocampo, amígdala, Locus coeruleus (LC) e Núcleo Dorsal da Rafe (NDR), para posterior análise dos níveis de RNAm para os receptores de progesterona (PR) e estradiol do tipo beta (ER?) por meio de RT/PCR. Este experimento foi replicado para remoção do hipocampo e amígdala para dosagem dos conteúdos de noradrenalina (NA) e serotonina (5-HT) por meio de cromatografia líquida de alta performance, seguida de detecção eletroquímica (HPLC/ED). Outro conjunto de ratas submetidas às mesmas condições10 experimentais foi perfundido para imunohistoquímica para TPH no NDR e TH no LC. Como esperado, na periestropausa (grupo VCD+O) as concentrações plasmáticas de estradiol não foram diferentes daquelas das ratas controles (O+O). As concentrações plasmáticas de progesterona na periestropausa foram menores que as do grupo controle, o que foi revertido pelo estradiol. No LC, a expressão de PR na periestropausa foi igual à das ratas controles, enquanto a expressão do ER? foi menor; a terapia com estradiol não modificou a expressão de nenhum destes receptores. A densidade de neurônios noradrenérgicos (TH+) no LC não foi alterada nem pela depleção folicular nem pela terapia estrogênica. Na periestropausa, o conteúdo de NA foi menor na amígdala, mas não no hipocampo, e o estradiol não alterou este conteúdo em nenhuma das áreas. No NDR, a expressão de PR e de ER? nas ratas na periestropausa foi menor que nas ratas controles; o estradiol preveniu o declínio da expressão de ER?, mas não de PR. O NDR foi analisado separadamente por toda a extensão rostro-caudal em 3 níveis anatômicos: rostral, médio e caudal, cada um dividido em 3 sub-regiões: lateral, dorsal e ventral. O número de neurônios serotonérgicos (TPH+) no NDR foi menor na periestropausa, e o estradiol foi capaz de reverter esse efeito, atuando principalmente na região caudal. A expressão gênica de PR não foi alterada nem pela depleção folicular nem pela terapia estrogênica tanto na amígdala como no hipocampo. A expressão de ER? também não foi diferente na periestropausa, quando comparada ao grupo controle, mas o estradiol aumentou esta expressão no hipocampo. Tanto na amígdala como no hipocampo houve redução no conteúdo de 5-HT na periestropausa e estradiol foi capaz de reestabelecer os níveis deste neurotransmissor aos valores controles apenas no hipocampo. Estes dados elucidam, pelo menos em parte os mecanismos do efeito positivo da terapia estrogênica nos sintomas de mulheres normoestrogênicas na perimenopausa. Estes efeitos parecem não envolver de forma importante o sistema noradrenérgico central, mas resultar do aumento da biossíntese de progesterona periférica em associação com a regulação positiva de ER? no NDR e hipocampo, que parece potencializar a via serotonérgica NDR/HPC. Portanto, o desenvolvimento de novas terapias que ativem os ER? pode ser uma alternativa para obter os efeitos positivos da ação do estradiol, eliminando os efeitos colaterais das terapias de estradiol que normalmente resultam da ativação do ER?.
Perimenopause represents the transition from reproductive to non-reproductive life. It is usually characterized by neuroendocrine, metabolic and behavioural changes, which result from a follicular depletion and reduced number of ovarian follicles. During this period, women are more likely to express mood disorders and anxiety. The exposure of animals to diepoxide 4-vinylcyclohexene (VCD) is a well-established experimental model for perimenopause studies, as VCD induces loss of ovarian small follicles (primary and primordial) in mice and rats by accelerating the natural process of atresia. Although estrogens levels are normal or even high during perimenopause, estrogen therapy can be beneficial for symptomatic perimenopausal women. The aim of this study was to investigate whether gradual follicular depletion induced by VCD results in changes in the neurochemistry of female rats in brain nuclei that control mood and the role of estradiol on these changes. Female rats (28 days) were daily injected with VCD or corn oil (O) for 15 days. Around 55 days after the first injection, pellets of 17?-estradiol (E) or O were inserted s.c (Groups O+O; VCD+O; VCD+E). Around 21 days after, rats O+O and VCD+O were decapitated between 0900 h and 1100 of diestrus while rats VCD+E were decapitated exactly 21 days after the onset of E therapy. Another set of rats followed the same experimental design and were perfused for TH and TPH immunohistochemistry in Locus coeruleus (LC) and Dorsal Raphe Nuclei (DRN), respectively. Blood was collected for estradiol and progesterone measurement by radioimmunoassay (RIA). The brains were removed from decapitated rats to punch out LC, DRN, hippocampus and amygdala to analyse the expression of mRNA for ER? and PR by RT/PCR. This experiment was replicated to punch out the hippocampus and amygdala for the determination of noradrenaline (NE) and serotonin (5-HT) contents by High Performance Liquid Chromatography, followed by Electrochemical Detection (HPLC/ED). As expected, plasma concentrations of estradiol were not different from those of control rats (O + O). Plasma concentrations of progesterone in the periestropause were lower than those in the control group, which was reversed by estradiol. In the LC, the PR expression in the periestropause was similar to that of the control rats, whereas the ER? expression was lower; estradiol therapy did not modify the expression of any of these receptors. The12 density of noradrenergic (TH +) neurons in LC was not altered by either follicular depletion or estrogen therapy. In periestropause, NA content was lower in the amygdala, but not in the hippocampus, and estradiol did not alter this content in any of the areas. In NDR, the expression of PR and ER? in periestropausal rats was lower than in controls; estradiol prevented the decrease of ER? expression, but not PR. The NDR was analyzed separately for the entire rostrocaudal axis in three anatomical levels: rostral, middle and caudal, each divided into three sub-regions: lateral, dorsal and ventral. The number of serotonergic neurons (TPH +) in NDR was lower in the periestropause, and estradiol was able to reverse this effect, acting mainly in the caudal region. PR gene expression was not altered by either follicular depletion or estrogen therapy in either the amygdala or the hippocampus. ER? expression was also no different in periestropause compared to the control group, but estradiol increased this expression in the hippocampus. Both in the amygdala and in the hippocampus there was a reduction in 5-HT content in the periestropause, and estradiol was able to reestablish the levels of this neurotransmitter at the control values only in the hippocampus. These data elucidate, at least in part, the mechanisms of the positive effect of estrogen therapy on the symptoms of normoestrogenic women in perimenopause. These effects do not appear to significantly involve the central noradrenergic system but result from increased peripheral progesterone biosynthesis in association with positive regulation of ER? in the NDR and hippocampus, which appears to potentiate the serotonergic NDR/HPC pathway. Therefore, the development of new therapies that activate ER? may be an alternative to obtain the positive effects of the estradiol action, eliminating the side effects of the estradiol therapies that normally result from the activation of ER?.
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Olson, Ann Colleen Falkenberg. "Perimenopausal Women's Intended and Actual Behavioral Response to Bone Health Interventions." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194232.

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The purpose of this longitudinal repeated measures experimental study was to determine the effects of bone health testing using dual energy X-ray absorptiometry (DXA) on outcomes of intentions toward and actual engagement in bone health behaviors (calcium intake, vitamin D intake, physical activity) among perimenopausal women. The Perimenopausal Bone Health Behaviors Model was developed based on the Theory of Planned Behavior and guided this study to determine how perimenopausal women respond to DXA and bone health information compared to bone health information only.One hundred fifty community-based perimenopausal women (ages 35-55) were randomly assigned to an intervention group (n=75 DXA and bone health information) or to a comparison group (n=75 bone health information). Baseline demographic data were collected. The Prevention Intentions Questionnaire and Behaviors Questionnaire were administered at baseline, at two weeks, and at two months after both groups received assigned interventions.Results showed 32% (n = 24) of intervention group women had low bone density. The intervention of DXA and bone health information showed near-significance (p = .068) over the intervention of bone health information alone in affecting women's intentions, and showed near-significance in affecting calcium intake (p = .052). Lower bone density test scores were related to higher intentions (r(74) = -.23, p = .046) at two weeks after DXA and bone health information, and were related to improved vitamin D intake (r(73) = -.25, p = .03) at two months after DXA and bone health information. At study end, Attitudes contributed 27.0% of the variance in Intentions among women who received DXA and bone health information; Attitudes, Subjective Norms, and Perceived Behavioral Control contributed 62.0% of the variance in Intentions among women who received bone health information only.Nursing interventions focusing on perimenopausal women should include providing bone health information to all perimenopausal women. Interventions targeting attitudes toward bone health behaviors may motivate some perimenopausal women to participate in behaviors that contribute to decreased risk of osteoporosis. Early detection and intervention in perimenopausal bone loss may reduce osteoporosis morbidity and may impact women's quality of life, reduce financial consequences to individuals, families, communities, and the nation.
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Kist, William B. "The effect of a brief period of low-fat and low-carbohydrate diet on postprandial lipemia, caloric intake, and mood in normal weight and overweight/obese premenopausal women /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074416.

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Matos, Gabrielle Silveira Rocha. "Est?gio menopausal e n?veis hormonais no desempenho muscular e funcional em mulheres de meia idade: um estudo transversal." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/16751.

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Introduction: Hypoestrogenism is the main characteristic of female aging. It promotes significant changes in body composition, both in fat mass as in lean body mass, leading to a decrease in muscle strength and physical performance. Objective: The aim of this study was to test whether menopausal status and hormone levels are associated with muscular strength and physical performance in middle-aged women. Methods: In a cross-sectional study it was collected sociodemographic data, gynecological history, anthropometric and biochemical measures in women aged 40 to 65 years in Parnamirim-RN. The menopause status (pre, peri and post menopause) was determined by menstrual history. All women underwent three dimensions of physical performance assessment: handgrip dynamometry, gait speed and chair stands test - Short Physical Performance Battery (SPPB). Categorical data were presented as absolute and relative frequencies. Quantitative data were showed as mean and standard deviation and the normality of distribution was verified with Kolmogorov-Smirnov (KS) test. Biochemical measures of estradiol and follicle-stimulating hormone (FSH) were transformed to log10. ANOVA with Tukey post-test for comparison of variables between the groups pre, peri and post-menopausal was performed and then multiple linear regression analyzes. Results: Two hundred and seventy eight women aged 50.2 (?5.58) years composed this study, being 50 women in premenopausal status (18%), 122 in perimenopausal (43.9%), and 106 postmenopausal stage (38.1%). The groups were different in age (p=0.001), marital relationship duration (p <0.001), number of pregnancies (p=0.001) and parity (p=0.001). Differences in biochemical measures were observed among the groups: estradiol (p<0.001), FSH (p<0.001), total cholesterol (p=0.001). There were no differences in gait velocity between menopausal status. Values in mean of grip strength decreased by postmenopausal women to perimenopausal and premenopausal ones (24.5 ? 5.1, 25.6 ? 5.4, 26.9 ? 4.9 for post-stage, pre and peri menopausas, respectively, p = 0.02) and the performance of chair stands test was better in premenopausal women compared with that in peri and postmenopausal status (p = 0.02). In multiple linear regression for muscle strength, the variables that remained were: age, estradiol and somatic symptoms measured by Menopause Rating Scale-MRS (R2=0.15). While for the xiv chair-stands test the predictors were number of births and FSH values (R2=0.04). Conclusion: There is a relationship between the stages of menopause and muscle performance in measures of grip strength and sit-up test and these are influenced by the fall of estrogens levels. Data suggest that the decrease in muscle strength and physical performance already appear in the transition to menopause stage, pointing to the need for more research in this area and appropriate preventive interventions
Introdu??o: O envelhecimento feminino tem como principal caracter?stica o hipoestrogenismo, o que promove mudan?as significativas na composi??o corporal, tanto na massa gorda, quanto na massa magra, levando ao decl?nio da for?a muscular e do desempenho funcional. Objetivo: Investigar a rela??o entre o est?gio menopausal, n?veis hormonais, desempenho muscular e funcional em mulheres de meia idade. M?todos: Realizou-se um estudo transversal, onde foram coletados dados sociodemogr?ficos, hist?rico ginecol?gico, medidas antropom?tricas e dosagens bioqu?micas de uma popula??o de mulheres entre 40 e 65 anos do munic?pio de Parnamirim-RN. A fase reprodutiva das mulheres (pr?, peri e p?s-menopausa) foi determinada pelo ciclo menstrual. Foi realizada dinamometria da preens?o palmar e aplicada a Short Physical Performance Battery (SPPB), do qual se considerou a velocidade da marcha e tempo de realiza??o do teste levantar-sentar para analisar o desempenho funcional. A apresenta??o para dados categ?ricos deu-se por frequ?ncias absolutas e relativas. Dados quantitativos foram apresentados por m?dia e desvio-padr?o e a normalidade da distribui??o foi verificada pelo teste de Kolmogorov-Smirnov (K-S). As medidas bioqu?micas do estradiol e FSH foram transformadas para log10, e em seguida, foi aplicado o teste de an?lise de vari?ncia (ANOVA), com p?s-teste de Tukey, para compara??o das vari?veis entre os grupos pr?, peri e p?s-menopausadas. Por fim, foi realizada an?lise de regress?o linear m?ltipla para identificar o grau de predi??o das vari?veis. Resultados: Foram avaliadas 278 mulheres, com m?dia de idade de 50,2 (?5,58) anos, sendo 50 em pr?-menopausa (18%), 122 em perimenopausa (43,9%) e 106 em p?s-menopausa (38,1%). Foram significativamente diferentes entre os grupos, as vari?vies idade (p=0,001), o tempo de uni?o est?vel (p<0,001), n?mero de gravidezes (p=0,001) e de partos (p=0,001). Quanto aos exames bioqu?micos, foram observadas diferen?as significativas entre os grupos para os valores de Estradiol (p<0,001), FSH (p<0,001) e Colesterol Total (p=0,001). N?o foram encontradas diferen?as na velocidade da marcha entre os diferentes est?gios. Mulheres em p?s-menopausa apresentaram os menores valores em m?dia de for?a de preens?o palmar quando comparado com em perimenopausa e estas, menores que as em pr?-menopausa (24.5 ? 5.1, 25.6 ? 5.4, 26.9 ? 4.9 para est?gios p?s, peri e pr?- xii menopausas respectivamente; p=0,02) e o desempenho do teste levantar-sentar foi melhor naquelas em pr?-menopausa quando comparado com aquela em peri e p?s-menopausa (p=0,02). No modelo de an?lise de regress?o linear m?ltipla, para a vari?vel for?a muscular, permaneceram a idade, estradiol e sintomas som?ticos do Menopause Rating Scale-MRS (R2= 0,15). A vari?vel levantar-sentar teve como preditores o n?mero de partos e o FSH (R2= 0,04). Conclus?o: Existe uma rela??o entre os est?gios de menopausa e o desempenho muscular nas medidas de for?a de preens?o palmar e teste levantar-sentar. Estas s?o influenciadas pela queda nos n?veis s?ricos de estrog?nios. Os dados sugerem que o decr?scimo da for?a muscular e as altera??es no desempenho aparecem j? na transi??o para a menopausa, em mulheres em meia-idade, apontando para a necessidade de mais estudos nesta ?rea e interven??es preventivas apropriadas
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Ehle, Anita Verfasser], Vanadin R. [Akademischer Betreuer] Seifert-Klauss, and Ernst-Josef [Akademischer Betreuer] [Rummeny. "Zum Einfluss des Ovulationsgeschehens auf Knochenstoffwechsel und Knochendichte in der Perimenopause : Basis-Daten und erste Verläufe der PEKNO (Perimenopausale Knochendichte und Ovulation)-Studie / Anita Ehle. Gutachter: Vanadin R. Seifert-Klauss ; Ernst J. Rummeny. Betreuer: Vanadin R. Seifert-Klauss." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1014330467/34.

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Books on the topic "Perimenopause"

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Lobo, Rogerio A., ed. Perimenopause. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0.

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T, Burkman Ronald, ed. Perimenopause. Philadelphia: Saunders, 2002.

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A, Lobo Rogerio, Serono Symposia USA, and International Symposium on Perimenopause (1995 : Palm Beach Gardens, Fla.), eds. Perimenopause. New York: Springer, 1997.

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Perimenopause. Philadelphia: W.B. Saunders Co., 2002.

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Brenner, Keri. Perimenopause the natural way. New York: John Wiley, 2001.

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A, Badawy Shawky Z., ed. Clinical management of perimenopause. London: Arnold, 1999.

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Sun-Cua, Alice M. The transition years: Perimenopause in Filipino women. Iloilo City, Philippines: University of San Agustin Pub. House, 2008.

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V, Wright Carol, ed. A woman's guide to menopause & perimenopause. New Haven: Yale University Press, 2005.

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The Hormone Survival Guide for Perimenopause. Chicago: Flashlight Press, 2005.

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What you need to know about perimenopause. Freedom, Calif: Crossing Press, 1998.

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Book chapters on the topic "Perimenopause"

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Utian, Wulf H. "Perimenopause." In Encyclopedia of Women’s Health, 994–96. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-0-306-48113-0_332.

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Baker, Julien S., Fergal Grace, Lon Kilgore, David J. Smith, Stephen R. Norris, Andrew W. Gardner, Robert Ringseis, et al. "Perimenopause." In Encyclopedia of Exercise Medicine in Health and Disease, 694. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_4446.

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Lobo, Rogerio A. "What Is the Perimenopause?" In Perimenopause, 1–3. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_1.

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Scott, Richard T. "Clinical Signs of Gametogenic Failure in Women." In Perimenopause, 119–43. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_10.

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Seifer, David B. "Granulosa Cell Competence with Aging." In Perimenopause, 144–53. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_11.

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Reame, Nancy E. "Gonadotropin Changes in the Perimenopause." In Perimenopause, 157–69. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_12.

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Burger, Henry G. "Inhibin and Steroid Changes in the Perimenopause." In Perimenopause, 170–83. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_13.

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Kronenberg, Fredi. "Vasomotor Symptoms in the Perimenopause." In Perimenopause, 184–201. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_14.

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Ettinger, Bruce. "Osteoporosis and the Perimenopausal Woman." In Perimenopause, 202–9. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_15.

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Stein, Daniel E., and Nanette Santoro. "Cardiovascular Changes of the Perimenopause and Menopause." In Perimenopause, 210–32. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2288-0_16.

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Conference papers on the topic "Perimenopause"

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Miao, Mingsan, Chaojun Hou, Shaoyan Liu, Bolin Cheng, and Shuo Tian. "Effects of total flavonoids ofcynomorium songaricumon perimenopausal mice model." In International conference on Human Health and Medical Engineering. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/hhme130251.

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Moreira, Mariana Vanon, Aline Batista Brighenti dos Santos, Júlia Abrahão Lopes, and Cecília Barra de Oliveira Hespanhol. "Efeitos da suplementação de vitamina D na prevenção do câncer de mama em mulheres na perimenopausa: uma revisão sistemática." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311032.

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Introdução: A qualidade da avaliação da mamografia está inversamente associada à densidade mamária, um dos biomarcadores para o câncer de mama. Em mamas densas, que possuem predomínio de tecido glandular e de suporte, o risco para o desenvolvimento desse tipo de doença é quatro vezes maior quando comparado às mamas de baixa densidade. Dados epidemiológicos e pré-clínicos levantaram possíveis impactos anticâncer da vitamina D por meio de seu receptor, considerado um fator de transcrição dependente de ligante que desempenha papel em processos celulares como apoptose e proliferação celular. Destarte, a teoria de que o aumento dos níveis de vitamina D poderia ter efeitos clinicamente benéficos contra tumores de mama em mulheres foi fortalecida. Objetivo: Analisar na literatura a eficácia da vitamina D na prevenção da alteração da densidade da mama e consequente prevenção do câncer de mama em mulheres na perimenopausa. Material e método: Em abril de 2021, foi realizada uma revisão sistemática na base de dados Medical Literature Analysis and Retrieval System Online (MEDLINE) utilizando os descritores: “vitamin D”, “breast cancer”, “breast density changes” e suas variações, obtidas do Medical Subject Headings (MeSH). Foram incluídos ensaios clínicos controlados e randomizados (ECCR) publicados nos últimos cinco anos na língua inglesa. Resultados: Foram encontrados 16 artigos, quatro dos quais foram empregados na confecção deste trabalho. Três ECCR duplo-cego selecionados envolveram, ao todo, 1.113 mulheres com idade próxima à perimenopausa sem histórico de câncer ou contraindicações para a ingestão de vitamina D, as quais foram divididas em grupo controle (ou grupos) e grupo experimental. Os grupos experimentais receberam vitamina D 50.000 UI, dois comprimidos de 10.000 UI, ou foram divididos em grupos para compaação da ingestão de 1.000, 2.000 ou 3.000 UI com o placebo. Em todos os grupos, os comprimidos foram administrados semanalmente pelo período de um ano ou mais. Os grupos controle receberam placebo. Os resultados encontrados em todos os estudos não apresentaram diferenças significativas na densidade mamária após a administração de suplementação nesse período de tempo em mulheres na perimenopausa, quando comparados aos do grupo placebo. Conclusão: Por conseguinte, o uso de vitamina D na dieta, o tempo no sol e a suplementação não demonstram eficiência na prevenção do câncer de mama em mulheres nessa idade. Porém, estudos futuros com maiores espaços amostrais e múltiplas doses de vitamina D por período de tempo maior são sugeridos. Isso posto, ocorre enfraquecimento da hipótese de que a vitamina D esteja inversamente associada à densidade mamária.
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Xin, Weiyun, Ming Bai, Lihua Cao, Mingsan Miao, Shuo Tian, and Le Kang. "Effect of total flavone of epimedium on the mice model of perimenopausal syndrome." In 2016 National Convention on Sports Science of China, edited by Z. Henan and J. Y. Beijing. Les Ulis, France: EDP Sciences, 2017. http://dx.doi.org/10.1051/ncssc/201701048.

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"Observation on the Efficacy of Auricular Acupoint Pressing Therapy in Perimenopausal Insomnia Patients." In 2020 International Conference on Social Sciences and Social Phenomena. Scholar Publishing Group, 2020. http://dx.doi.org/10.38007/proceedings.0001107.

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Britto, Júlia Macedo de, and Rita Maira Zanine. "Os achados da colposcopia em mulheres na perimenopausa para rastreio das lesões precursoras do carcinoma cervical uterino." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311069.

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Introdução: A detecção precoce do câncer de colo uterino é essencial para a diminuição da incidência e para o tratamento do câncer. Porém, a literatura tem indicado que existem diferenças no rastreio de mulheres em período reprodutivo e pós-menopausa. O presente estudo tem por objetivo principal determinar a acurácia dos achados colposcópicos no diagnóstico das lesões intraepiteliais de colo uterino nas mulheres no pós-menopausa. Como objetivos secundários: eeterminar a acurácia da citologia oncótica no diagnóstico das lesões intraepiteliais de colo uterino; determinar a sensibilidade (S), a especificidade (E), o valor preditivo positivo (VPP) e o valor preditivo negativo (VPN) da colposcopia em relação ao exame histopatológico; determinar S, E, VPP e VPN da citologia em relação ao exame histopatológico. Metodologia: Trata-se de um estudo analítico, retrospectivo, transversal e observacional, baseado na análise de prontuários de pacientes que foram encaminhadas da rede básica de saúde ao ambulatório de patologia do trato genital inferior e colposcopia de um centro terciário em razão de alteração no exame citopatológico convencional, no período de fevereiro de 2011 a agosto de 2018, e que se encontram no pós-menopausa. As citopatologias foram classificadas pelo Sistema Bethesda, 2001. Foram coletados os resultados da citologia oncótica, da colposcopia e da histopatologia (cone/cirurgia de alta frequência - CAF). Resultados: Analisaram-se 55 mulheres com mais de 50 anos de idade. A acurácia da citologia foi de 76,3%; S=87,5%; E=43,7%; VPP=79,5% e VPN=58,3%. Os mesmos valores para a colposcopia foram, respectivamente, acurácia 60%; S=60%; E=60%, VPP=80% e VPN=36%. Conclusão: Deve-se ter cautela na realização e interpretação dos resultados dos testes de rastreio convencionais em mulheres no período pós-menopausa. Em consequência de alterações fisiológicas típicas do climatério, como a não visualização da junção escamo-colunar e a atrofia do epitélio cervicovaginal, sua efetividade é menor que em mulheres em idade reprodutiva.
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Iqbal, S. A., H. Shukla, V. Jain, S. Giri, R. Sekhon, and S. Rawal. "Synchronous primary ovarian sex cord tumor and endometrial cancer." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685384.

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Synchronous primary tumors of female genital tract are rare with a rate of about 0.7-1.8% of all gynaecological tumours. Most common primary tumours presenting as synchronous lesions are ovary and endometrium. However, sex cord stromal tumors are rare variety of primary ovarian tumor and synchronous with endometrium is even much rarer. These tumors are detected usually in younger, overweight, nulliparous and perimenopausal female. Synchronous primary tumors of endometrium and ovary have a better prognosis than the either of above alone because these are usually low grade and diagnosed at early stage. We present a report of four cases of synchronous endometrial and sex cord stromal tumors of ovary.
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Pertseva, Tetyana, and Tetyana Choursinova. "Peculiarities of climacteric syndrome in women with bronchial asthma, developed in the perimenopausal period, correction of these disorders." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa648.

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Liu, Jun, Jian-ke Pan, Ji-yuan Yang, Da Guo, Wei-yi Yang, Xiang Li, Yu-yao Wan, and Shu-chai Xu. "Study on the distinguishing feature in use of Chinese drugs on cervical spondylosis patients in perimenopausal period through data mining methods." In 2013 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2013. http://dx.doi.org/10.1109/bibm.2013.6732658.

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Baumgaertner, AK, A. Haeusler, VR Seifert-Klauss, T. Schuster, U. Schwarz-Boeger, and Klinikum Kiechle M. "Abstract P3-11-12: Influence of Hormone Therapy Prior to Breast Cancer Diagnosis on Prognosis of Postmenopausal and Perimenopausal Breast Cancer Patients." In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-p3-11-12.

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Savita, Pannu, and Khullar Harsha. "Two interesting cases of granulosa cell tumor: A case report." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685326.

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Introduction: Granulosa cell tumor (GCT) is an ovarian malignancy that arise from granulosa cells of the ovary. This tumour is a type of the sex cord-gonadal stromal tumour. GCT have good prognosis in comparison with other epithelial tumors. Methodology: Two cases of granulosa cell tumors were diagnosed in sir Ganga ram hospital, Rajendernagar, New Delhi in December 2015 and January 2016. The patient’s age, clinical manifestations, radiological and histopathological findings were evaluated. One was in perimenopausal age group and other case was in postmenopausal age group. The clinical manifestations were menorrhagia and abdominal pain. Ultrasonographically, in one case focal hypoechoic zone showing peripheral hypervascularity with possibility of old hemorrhage follicular cyst was seen and in other case of granulosa cell tumors was both solid and cystic areas were seen. Histologically, variety of patterns like diffuse, trabecular, nodular, sheets, nests and fascicular patterns with nuclear grooving in ovarian tissue. In addition endometrial findings were suggestive of simple hyperplasia without atypia. Treatment modalility used was surgery i.e., Total hysterectomy and bilateral salpingo-oophorectomy in both cases. Conclusion: Granulosa cell tumor of the ovary is a rare ovarian malignancy. Endometrial pathology to rule out endometrial carcinomaspecially when postmenopausal bleeding is concomitant finding is advised. Radical surgery is usually not required.
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Reports on the topic "Perimenopause"

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Thayer, Colette, and Cheryl L. Lampkin. There Is More to Perimenopause Than Hot Flashes. Washington, DC: AARP Research, May 2021. http://dx.doi.org/10.26419/res.00431.001.

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Thayer, Colette, and Cheryl L. Lampkin. There Is More to Perimenopause Than Hot Flashes: Annotated Questionnaire. Washington, DC: AARP Research, May 2021. http://dx.doi.org/10.26419/res.00431.002.

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Ping, Yanpei, Chao Liang, Xixi Fan, and Zhongnan Wang. Can acupuncture improve sleep quality and anxiety among women during perimenopause? A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2021. http://dx.doi.org/10.37766/inplasy2021.11.0095.

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Chen, Jie. Association analysis between vitamin D level and depression in women perimenopause: A protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0117.

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Ping, Yanpei, Chao Liang, Xixi Fan, Lili Zhang, Dashi Ying, and Zhongnan Wang. Can acupuncture improve sleep quality and anxiety among women during perimenopause?A protocol for systemic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0012.

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huang, shuwen, you wu, qiuping ren, jianying shen, wenna liang, and candong li. The efficacy of the Five Phases Music Therapy (FPMT) in the treatment for anxiety and depression during perimenopause: A protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0109.

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huang, shuwen, you wu, qiuping ren, jianying shen, wenna liang, and candong li. The efficacy of the Five Phases Music Therapy (FPMT) in the treatment for anxiety and depression during perimenopause: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0113.

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LI, XIAOJUAN, YU YUAN, SHANSHAN LI, YONGQING YANG, HONGYONG DENG, and SHIFEN XU. Complementary and alternative therapies for perimenopausal insomnia. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2021. http://dx.doi.org/10.37766/inplasy2021.9.0061.

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Wang, Zhao, Fengting Zhai, Xiaomin Zhao, Guizhi Zhao, Na Li, Fang Zhang, and Jinxing Liu. The efficacy and safety of acupuncture for perimenopausal insomnia: a network meta-analysis protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0047.

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Gao, zhan, Mingzhou Gao, changlin Wang, Dongmei Gao, Mingqi Qiao, Jie Gao, and Jieqiong Wang. Treatment of Perimenopausal Depression with Acupuncture Combined with Chinese herbal medicine：A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0122.

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