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Relevant bibliographies by topics / Peri-conceptional

Academic literature on the topic 'Peri-conceptional'

Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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Journal articles on the topic "Peri-conceptional"

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Toschi, Paola, Emanuele Capra, Debora A. Anzalone, Barbara Lazzari, Federica Turri, Flavia Pizzi, Pier A. Scapolo, et al. "Maternal peri-conceptional undernourishment perturbs offspring sperm methylome." Reproduction 159, no. 5 (May 2020): 513–23. http://dx.doi.org/10.1530/rep-19-0549.

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The genotype of an organism is stable throughout its life; however, its epigenome is dynamic and can be altered in response to environmental factors, such as diet. Inheritance of acquired epigenetic modifications by the next generation occurs through the germline, although the precise mechanisms remain to be elucidated. Here, we used a sheep model to evaluate if modification of the maternal diet (CTR; control, UND: undernutrition; FA: undernutrition and folic acid supplementation) during the peri-conceptional period affects the genome-wide methylation status of the gametes of male offspring. Sperm DNA methylation, measured by Reduced Representation Bisulfite Sequencing (RRBS), identified Differentially Methylated Regions (DMR) in offspring that experienced in utero undernutrition, both in UND (244) and FA (240), compared with CTR. Gene ontology (GO) analysis identified DMRs in categories related to sperm function, therefore we investigated whether the fertilizing capacity of the semen from the three groups differed in an in vitro fertilization assay. Spermatozoa from the undernourished groups showed lower motility and sperm chromatin structure abnormalities, represented by a higher percentage of DNA fragmentation and an increased number of immature cells, compared with CTR. While good quality blastocysts were obtained from all three groups, the proportion of embryos reaching the blastocyst stage was reduced in the UND vs CTR, an effect partially rescued by the FA treatment. The data reported here show that nutritional stress during early pregnancy leads to epigenetic modifications in the semen of the resulting offspring, the effects of which in next generation remain to be elucidated.

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Toschi, P., E. Capra, D. Anzalone, F. Turri, F. Pizzi, B. Lazzari, A. Stella, P. Ajmone-Marsan, and P. Loi. "55 Peri-conceptional undernourishment perturbs offspring sperm methylome." Reproduction, Fertility and Development 31, no. 1 (2019): 153. http://dx.doi.org/10.1071/rdv31n1ab55.

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Whereas an organism’s genotype is relatively static throughout life, the epigenome is highly dynamic and can adapt, or be altered, in response to the external environment such as diet. Intrauterine exposure to nutrient availability can alter the establishment of epigenetic marks, not only in the exposed individuals, but also in their offspring. Inheritance of such an environmentally acquired phenotype by the subsequent generation occurs through epigenetic modifications in the germline. Here, using a genome-wide approach, we evaluate how modification of the maternal diet pre- (14 days) and post- (28 days) conception can affect methylation status of the sperm of male offspring. Specifically, using a sheep model, we focused on the effect of maternal undernutrition on adult sperm methylation and its long-term consequences on sperm physiology and quality. Moreover, we investigated if supplementation of folic acid, to increase the availability of methyl donors, could prevent or ameliorate the adverse uterine environment caused by maternal undernutrition. Male lambs obtained from mothers subjected to different nutritional regimens (UND: undernutrition; FA: undernutrition and folic acid supplementation) appeared normal at birth, with a comparable body weight until Day 30 postpartum. Sperm DNA methylation, obtained by reduced representation bisulfite sequencing, differed in offspring that experienced in utero undernutrition (UND and FA) compared with the control group (CTR). In particular, the number of differentially methylated regions (DMR) was lower when UND and FA groups were compared, whereas a higher number of DMR was observed by comparison of CTR with both experimental groups. In addition, a high percentage of DMR were shared between UND and FA groups when compared with CTR, clearly indicating a influence of maternal nutrition on the offspring sperm DNA methylation rearrangement. Gene ontology (GO) analysis showed variation in functional categories related to sperm functionality such as chondroitin sulfate synthesis, potassium ion import, and others related to metabolism (biotin and glucagon). Furthermore, using computer-assisted semen analysis and flow cytometric measurement, we observed lower a sperm motility index and higher incidence of chromatin structure alterations in spermatozoa collected from UND and FA groups compared with CTR. Finally, to verify the effect of such reported abnormality on lamb fertility, we used the semen for in vitro embryo production. While we obtained good quality blastocysts from all 3 groups, a reduction in the percentage of embryo development, partially compensated in the FA group, was found using spermatozoa from UND rams. Taken together, our results confirm that a nutritional stress during early mammalian development can lead to epigenetic modification in the offspring. This damage can be partially ameliorated with folic acid supplementation; however, some alteration still persists in the germline and could be passed to the next generation, with as yet unknown consequences.

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Franczak, A., K. Zglejc, E. Waszkiewicz, B. Wojciechowicz, M. Martyniak, W. Sobotka, S. Okrasa, and G. Kotwica. "Periconceptional undernutrition affects in utero methyltransferase expression and steroid hormone concentrations in uterine flushings and blood plasma during the peri-implantation period in domestic pigs." Reproduction, Fertility and Development 29, no. 8 (2017): 1499. http://dx.doi.org/10.1071/rd16124.

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Female undernutrition during early pregnancy may affect the physiological pattern of genomic DNA methylation. We hypothesised that in utero DNA methylation may be impaired in females fed a restrictive diet in early pregnancy. In this study we evaluated whether poor maternal nutritional status, induced by applying a restricted diet during the peri-conceptional period, may influence: (1) the potential for in utero DNA methylation, expressed as changes in the mRNA expression and protein abundance of methyltransferases: DNA methyltransferase 1 (DNMT1) and DNMT3a in the endometrium and the myometrium, (2) the intrauterine microenvironment, measured as oestradiol 17β (E2) and progesterone (P4) concentrations in uterine flushings and (3) plasma concentration of E2 and P4 during the peri-implantation period. Our results indicate that maternal peri-conceptional undernutrition affects maintenance and de novo DNA methylation in the endometrium, de novo methylation in the myometrium and a results in a decrease in intrauterine E2 concentration during the peri-implantation period. The intrauterine concentration of P4 and plasma concentrations of E2 and P4 did not change. These findings suggest that undernutrition during the earliest period of pregnancy, and perhaps the pre-pregnancy period, may create changes in epigenetic mechanisms in the uterus and intrauterine milieu of E2 during the peri-implantation period.

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Franczak, Anita, Kamila Zglejc-Waszak, Marcin Martyniak, Ewa Monika Waszkiewicz, and Genowefa Kotwica. "Peri-conceptional nutritional restriction alters transcriptomic profile in the peri-implantation pig embryos." Animal Reproduction Science 197 (October 2018): 305–16. http://dx.doi.org/10.1016/j.anireprosci.2018.08.045.

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NWOSU, T. FARRELL and C. "Compliance with the peri-conceptional folic acid supplementation guidelines." Journal of Obstetrics and Gynaecology 17, no. 3 (January 1997): 253–54. http://dx.doi.org/10.1080/01443619750113177.

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6

Greene, Nicholas D. E., Kit-Yi Leung, Victoria Gay, Katie Burren, Kevin Mills, Lyn S. Chitty, and Andrew J. Copp. "Inositol for the prevention of neural tube defects: a pilot randomised controlled trial." British Journal of Nutrition 115, no. 6 (February 5, 2016): 974–83. http://dx.doi.org/10.1017/s0007114515005322.

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AbstractAlthough peri-conceptional folic acid (FA) supplementation can prevent a proportion of neural tube defects (NTD), there is increasing evidence that many NTD are FA non-responsive. The vitamin-like molecule inositol may offer a novel approach to preventing FA-non-responsive NTD. Inositol prevented NTD in a genetic mouse model, and was well tolerated by women in a small study of NTD recurrence. In the present study, we report the Prevention of Neural Tube Defects by Inositol (PONTI) pilot study designed to gain further experience of inositol usage in human pregnancy as a preliminary trial to a future large-scale controlled trial to evaluate efficacy of inositol in NTD prevention. Study subjects were UK women with a previous NTD pregnancy who planned to become pregnant again. Of 117 women who made contact, ninety-nine proved eligible and forty-seven agreed to be randomised (double-blind) to peri-conceptional supplementation with inositol plus FA or placebo plus FA. In total, thirty-three randomised pregnancies produced one NTD recurrence in the placebo plus FA group (n 19) and no recurrences in the inositol plus FA group (n 14). Of fifty-two women who declined randomisation, the peri-conceptional supplementation regimen and outcomes of twenty-two further pregnancies were documented. Two NTD recurred, both in women who took only FA in their next pregnancy. No adverse pregnancy events were associated with inositol supplementation. The findings of the PONTI pilot study encourage a large-scale controlled trial of inositol for NTD prevention, but indicate the need for a careful study design in view of the unwillingness of many high-risk women to be randomised.

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Martyniak, Marcin, Kamila Zglejc-Waszak, Anita Franczak, and Genowefa Kotwica. "Transcriptomic analysis of the oviduct of pigs during the peri-conceptional period." Animal Reproduction Science 197 (October 2018): 278–89. http://dx.doi.org/10.1016/j.anireprosci.2018.08.040.

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Robertson, Sarah A. "Cytokines as mediators of cryptic female choice in the peri-conceptional environment." Journal of Reproductive Immunology 101-102 (March 2014): 13–14. http://dx.doi.org/10.1016/j.jri.2013.12.022.

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Su, H., A. Wang, J. Hu, X. Chen, J. Wang, H. Ma, W. Bai, Z. Liu, and H. Zhang. "OP26.06: Association between peri-conceptional multiple nongenetic risk factors with congenital heart disease." Ultrasound in Obstetrics & Gynecology 44, S1 (September 2014): 126. http://dx.doi.org/10.1002/uog.13892.

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Bloomfield, Frank. "The peri-conceptional origins of the life-long physiological consequences of being a twin." Physiology News, Summer 2009 (July 1, 2009): 31–33. http://dx.doi.org/10.36866/pn.75.31.

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Dissertations / Theses on the topic "Peri-conceptional"

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Kakar, Muhammad Azam. "Effect of peri-conceptional feed intake on early embryo development and fetal growth in the Merino ewe /." Title page, table of contents and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09ANP/09anpk138.pdf.

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Schelbach, Cheryl J. "An investigation into the effect of glucosamine on reproductive outcomes in the mouse." Thesis, 2012. http://hdl.handle.net/2440/83569.

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It is well established that conditions experienced in utero by the developing fetus can elicit permanent effects on the post natal period. Although not as well understood, a growing body of research also suggests that this can also occur in response to peri-conceptional insult. Glucosamine (GlcN) is a popular dietary supplement that is also used experimentally as a hyperglycaemic mimetic. The work contained in this thesis tests the hypothesis that pre and peri-conceptional exposure to GlcN has adverse effects on reproductive outcomes in the mouse. Preliminary experiments (Chapter 2) confirmed that the inclusion of GlcN into the in vitro maturation (IVM) media used for mouse cumulus oocyte complex (COC) maturation, reduced oocyte developmental potential. Subsequent experiments (Chapter 3) demonstrated that the inhibition of O-linked glycosylation of unknown proteins reversed the effects of GlcN. It was also shown that GlcN exposure during IVM altered Pentose phosphate pathway (PPP) activity within the oocyte. As predicted, preliminary in vivo experiments performed in Chapter 4 showed that maternal, peri-conceptional GlcN administration compromised fetal development. This was seen by a decreased mean implantation rate and litter size as well as an increase in the proportion of fetal resorptions on gestational day 18 (d18), and provided the impetus to examine the in vivo effects of GlcN exposure more carefully. It was subsequently hypothesized that these adverse effects would be heightened if given to mice with overweight-induced metabolic pathologies. In contrast to Chapter 4 outcomes, GlcN elicited no effects on d18 implantation, resorption or litter size parameters, but did reduce fetal weight. Furthermore, birth defects were higher in mice given GlcN and maintained on a low fat (LF) diet. An additional cohort of mice was allowed to give birth, and offspring were assessed for 16 weeks. There was an unexpectedly high death rate in the offspring of mice maintained on a high fat (HF) diet but not given GlcN, therefore preventing optimally controlled post natal analyses to occur. Of the remaining mice, a number of physiological differences were detected within GlcN-exposed groups. Since the principle difference between mice in Chapters 4 and 5 was maternal age, an addition experiment investigating the effects of peri-conceptional GlcN exposure in 8 week and 16 week old mice was undertaken (Chapter 6). Consistent with previous results, GlcN treatment reduced mean implantation rate and litter size only in 8 week old mice and reduced fetal weigh and length solely in 16 week old mice. Increased birth defects were also detected in the HF group given GlcN. Collectively these results provide important insights into the importance of optimal conditions during the peri-conceptional period to facilitate successful subsequent development. They also provide evidence that GlcN is a simple but effective tool that can be used to further elucidate the impact of hyperglycaemic exposure during the early developmental period. This is of key importance given the escalating instances of diabetes and obesity in current day Western society, and the associated complications that these conditions elicit on reproductive parameters.
Thesis (Ph.D.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2012

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Books on the topic "Peri-conceptional"

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Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Choline in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0014.

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Choline is required for the structural integrity of cell membranes and is involved in methyl-group metabolism, neurotransmission, transmembrane signalling, and lipid and cholesterol transport and metabolism. Choline is critical during fetal and neonatal life to ensure optimal brain and cognitive development. There is an intersection of the pathways of choline, folate, and vitamin B12 in the formation of methionine from homocysteine. Maternal peri-conceptional deficiency for choline, like folate, is associated with an increased risk of neural tube defects in the offspring. It is recommended that pregnant women do not restrict fat severely from their diets, as choline is derived from the lipid content of food. Strict vegetarian or vegan diets may be low in choline. The high secretion rate of choline into breast milk means that lactating women have a high demand, and multivitamins containing choline may be helpful for both pregnancy and breastfeeding.

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Book chapters on the topic "Peri-conceptional"

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Evertz, Klaus. "Pre- and Peri-conceptional and Prenatal Psychology: Early Memories and Preverbal Approaches." In Handbook of Prenatal and Perinatal Psychology, 513–17. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41716-1_33.

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"Diet before and during pregnancy." In Oxford Handbook of Nutrition and Dietetics, edited by Joan Webster-Gandy, Angela Madden, and Michelle Holdsworth, 237–56. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198800132.003.0012.

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"Diet before and during pregnancy." In Oxford Handbook of Nutrition and Dietetics, edited by Joan Webster-Gandy, Angela Madden, and Michelle Holdsworth, 217–36. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199585823.003.0012.

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Pre- and peri-conceptional nutrition in women 218 Dietary reference values and dietary guidelines during pregnancy 222 Vitamin and mineral supplements in pregnancy 224 Food safety in pregnancy 226 Maternal weight gain 228 Dietary problems in pregnancy 230 Vulnerable groups in pregnancy 234 Useful websites 236...

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