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Journal articles on the topic 'Peptide production pilot plant'

Author: Grafiati

Published: 10 March 2023

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1

Guo, Minliang, Qingming Hou, Choy L. Hew, and Shen Q. Pan. "Agrobacterium VirD2-Binding Protein Is Involved in Tumorigenesis and Redundantly Encoded in Conjugative Transfer Gene Clusters." Molecular Plant-Microbe Interactions® 20, no. 10 (October 2007): 1201–12. http://dx.doi.org/10.1094/mpmi-20-10-1201.

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Agrobacterium tumefaciens can transfer oncogenic T-DNA into plant cells; T-DNA transfer is mechanistically similar to a conjugation process. VirD2 is the pilot protein that guides the transfer, because it is covalently associated with single-stranded T-DNA to form the transfer substrate T-complex. We used the VirD2 protein as an affinity ligand to isolate VirD2-binding proteins (VBPs). By pull-down assays and peptide-mass-fingerprint matching, we identified an A. tumefaciens protein designated VBP1 that could bind VirD2 directly. Genome-wide sequence analysis showed that A. tumefaciens has two additional genes encoding proteins highly similar to VBP1, designated vbp2 and vbp3. Like VBP1, both VBP2 and VBP3 also could bind VirD2; all three VBPs contain a putative nucleotidyltransferase motif. Mutational analysis of vbp demonstrated that the three vbp genes could functionally complement each other. Consequently, only inactivation of all three vbp genes highly attenuated the bacterial ability to cause tumors on plants. Although vbp1 is harbored on the megaplasmid pAtC58, vbp2 and vbp3 reside on the linear chromosome. The vbp genes are clustered with conjugative transfer genes, suggesting linkage between the conjugation and virulence factor. The three VBPs appear to contain C-terminal positively charged residues, often present in the transfer substrate proteins of type IV secretion systems. Inactivation of the three vbp genes did not affect the T-strand production. Our data indicate that VBP is a newly identified virulence factor that may affect the transfer process subsequent to T-DNA production.

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2

Alenezi, Faizah N., Ali Chenari Bouket, Hafsa Cherif-Silini, Allaoua Silini, Marcel Jaspars, Tomasz Oszako, and Lassaȃd Belbahri. "Loss of Gramicidin Biosynthesis in Gram-Positive Biocontrol Bacterium Aneurinibacillus migulanus (Takagi et al., 1993) Shida et al. 1996 Emend Heyndrickx et al., 1997 Nagano Impairs Its Biological Control Ability of Phytophthora." Forests 13, no. 4 (March 30, 2022): 535. http://dx.doi.org/10.3390/f13040535.

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The soil-borne species Aneurinibacillus migulanus (A. migulanus) strains Nagano and NCTC 7096 were shown to be potent biocontrol agents active against several plant diseases in agricultural and forest ecosystems. Both strains produce the cyclic peptide gramicidin S (GS) that was described as the main weapon inhibiting some gram-negative and gram-positive bacteria and fungus-like organisms along with the production of biosurfactant and hemolysis activities. However, the contribution of the cyclic peptide gramicidin S (GS) to the biocontrol ability of A. migulanus has never been studied experimentally. In this paper, using a mutant of the A. migulanus Nagano strain (E1 mutant) impaired in GS biosynthesis we evaluated the contribution of GS in the biocontrol potential of A. migulanus against Phytophthora spp. The two strains of A. migulanus, Nagano and NCTC 7096, were tested in a pilot study for the inhibition of the growth of 13 Phytophthora species in dual culture assays. A. migulanus Nagano was significantly more inhibitory than NCTC 7096 to all species. Additionally, using apple infection assays, P. rosacearum MKDF-148 and P. cryptogea E2 were shown to be the most aggressive on apple fruits displaying clear infection halos. Therefore, the three A. migulanus strains, Nagano, NCTC 7096, and E1, were used in apple infection experiments to check their effect on infection ability of these two Phytophthora species. Treatment with A. migulanus Nagano significantly reduced the severity of symptoms in apple fruits compared with NCTC 7096. A. migulanus E1 mutant showed total loss of biocontrol ability suggesting that GS is a major actor in the biocontrol ability of A. migulanus Nagano strain.

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3

Conic, Vesna, Vladimir Cvetkovski, Milovan Vukovic, and Milena Cvetkovska. "Pilot plant for biohidrometallurgical production of copper." Chemical Industry 63, no. 1 (2009): 51–56. http://dx.doi.org/10.2298/hemind0901051c.

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In this work, technical and technological characteristics of pilot plant for biohydrometallurgical production of copper financed by Ministry of Science and Environment Protection of Serbia, in the frame of capital providing for scientific research for the period 2006-2008 is presented. Presented within this project is the contribution and capability of the Institute for Mining and Metallurgy Bor to carry out the Fp6 IP project: 'Biotechnology for Metal Bearing Materials in Europe (BioMinE)'. In the pilot plant, processes such as: microbiological leaching, pressures oxidation, chemical purification of solutions, solvent extraction and electrowining of copper were carried out. Bioleaching can treat complex copper concentrates which are either unacceptable to smelting or attract high penalties. Some of the elements penalized in smelting (for example zinc) are dissolved in the bioleach process and can be recovered for sale. This may often allow an increased recovery of a few percent in the production of the copper concentrate. Bioleaching can be used in either small or large cathodic copper production from copper concentrate. Bioleaching uses conventional upstream and downstream process technology and the unit operation itself has been proven in the gold industry. For these reasons, this work describes the pilot plant for biotechnological production of copper from RTB Bor resources.

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4

Vaquero, C., R. Wendelbo, A. Egizabal, C. Gutierrez-Cañas, and J. López de Ipiña. "Exposure to graphene in a pilot production plant." Journal of Physics: Conference Series 1323 (October 2019): 012005. http://dx.doi.org/10.1088/1742-6596/1323/1/012005.

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5

POLEDNÍKOVÁ, M., J. VÝBORSKÝ, L. CHLÁDEK, and T. ŠRUMA. "Production using immobilized yeasts on pilot plant scale." Kvasny Prumysl 39, no. 1 (January 1, 1993): 2–7. http://dx.doi.org/10.18832/kp1993001.

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6

El-Shawarby, Sh I., E. A. El-Zanaty, A. H. El-Refai, F. A. Hamissa, and H. Shaker. "Pilot plant production of SCP from sugarcane bagasse." Biological Wastes 20, no. 4 (January 1987): 273–80. http://dx.doi.org/10.1016/0269-7483(87)90004-8.

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7

Liu, Guang Rui, and Guan Yi Chen. "Pilot Plant of Biodiesel Production from Waste Cooking Oil." Advanced Materials Research 550-553 (July 2012): 687–92. http://dx.doi.org/10.4028/www.scientific.net/amr.550-553.687.

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Biodiesel, as an alternative auto fuel for conventional fossil fuel, has drawn wide attention in recent years. In this research, a two-step process for biodiesel production using waste cooking oil as feedstock was studied in a pilot plant with a treatment capacity of 3 ton/d. The results show that: the process exihibited a good conversion ratio and the biodiesel displayed suitable physical-chemical properties in comparison with diesel fuel, such as flash point of 137°C, viscosity of 4.49 mm2/s, acid value of 0.44 mg KOH/g etc. The quality of biodiesel meets the agreement with the European specification defined by EN 14214. Afterwards, the mixture of biodiesel and diesel were test in the engine with a ratio of 50/50（v/v）, 20/80（v/v）, and 0/100（v/v）. It indicates the mixed fuel has a reasonable fuel consumption rates without diesel engine modification, when the biodiesel blended with 0# diesel as fuel. The present results demonstrated that the industrial scale plant would achieve promising objective with waste cooking oils and animal fats as raw material. Also, this biodiesel-based diesel fuel could be applied in Tianjin local public transportation system that improves its sustainable development.

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8

Reiling, H. E., U. Thanei-Wyss, L. H. Guerra-Santos, R. Hirt, O. Käppeli, and A. Fiechter. "Pilot plant production of rhamnolipid biosurfactant by Pseudomonas aeruginosa." Applied and Environmental Microbiology 51, no. 5 (1986): 985–89. http://dx.doi.org/10.1128/aem.51.5.985-989.1986.

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9

Mann, Horace C., Kenneth E. McGill, and Mark T. Holt. "Pilot-plant production of ammonium polyphosphate sulfate suspension fertilizers." Industrial & Engineering Chemistry Product Research and Development 24, no. 4 (December 1985): 598–603. http://dx.doi.org/10.1021/i300020a020.

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10

Del Rosso, Renato, Paolo Gronchi, and Paolo Centola. "Pilot plant tests for glyoxal production: Reactor thermal behavior." Reaction Kinetics and Catalysis Letters 48, no. 2 (December 1992): 655–61. http://dx.doi.org/10.1007/bf02162722.

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11

Dörnenburg, Heike. "Progress in kalata peptide production via plant cell bioprocessing." Biotechnology Journal 4, no. 5 (May 18, 2009): 632–45. http://dx.doi.org/10.1002/biot.200800288.

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12

Prévot-D'Alvise, Nathalie, Christine Lesueur-Lambert, Anne Fertin-Bazus, Bertrand Fertin, and Pascal Dhulster. "Development of a pilot process for the production of alfalfa peptide isolate." Journal of Chemical Technology & Biotechnology 78, no. 5 (April 2, 2003): 518–28. http://dx.doi.org/10.1002/jctb.824.

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13

Nivison, Helen T., and Maureen R. Hanson. "Production and purification of synthetic peptide antibodies." Plant Molecular Biology Reporter 5, no. 2 (June 1987): 295–309. http://dx.doi.org/10.1007/bf02668993.

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14

Vigneron-Larosa, N., A. S. Lescourret, A. Bignon, C. Breda, B. Bozkaya-Schrotter, C. Daines, and J. C. Schrotter. "Pilot plant trials: management of membrane concentrate." Water Supply 10, no. 4 (September 1, 2010): 591–99. http://dx.doi.org/10.2166/ws.2010.179.

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In surface water nanofiltration (NF) for drinking water production, 15 to 25% of the feed is rejected by the membranes. Two complementary approaches are investigated in order to manage concentrates. On one hand, an additional NF stage allows an increase in the yield of drinking water production from 85 to 94%. Thirty-days filtration cycles are achieved. Conductivity, natural organic matter (NOM) and micropollutant contents of permeate fully satisfy drinking water standards. On the other hand removal of phosphonates, micropollutants and NOM is investigated in order to treat the concentrate before disposal. Phosphorus is removed by adsorption on pre-treatment sludge: removal reaches 82% with 100 ppm of suspended solids. To eliminate pesticides and NOM, adsorption on granular activated carbon (GAC) is studied with pilot scale fixed bed columns. Within 20 minutes contact time, selected pesticides are completely eliminated. NOM removal is approximately 30% with wood based GAC.

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15

Baptiste Nduwayezu, Jean, Theoneste Ishimwe, Ananie Niyibizi, and Alexis Munyentwali. "Biodiesel Production from Unrefined Palm Oil on Pilot Plant Scale." International Journal of Sustainable and Green Energy 4, no. 1 (2015): 11. http://dx.doi.org/10.11648/j.ijrse.20150401.13.

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16

Sundaram, C. V., C. M. Paul, B. P. Sharma, J. S. Nair, and S. Saha. "Pilot Plant Production of Beryllium Metal and Copper-Beryllium Alloys." Key Engineering Materials 8 (January 1985): 251–71. http://dx.doi.org/10.4028/www.scientific.net/kem.8.251.

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17

Breed, C. E., K. E. McGill, and M. T. Holt. "Pilot‐plant production of a concentrated ammonium polyphosphate suspension fertilizer." Journal of Environmental Science and Health . Part A: Environmental Science and Engineering 21, no. 6 (August 1986): 609–23. http://dx.doi.org/10.1080/10934528609375315.

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18

De Francesco, Giovanni, Valeria Sileoni, Ombretta Marconi, and Giuseppe Perretti. "Pilot Plant Production of Low-Alcohol Beer by Osmotic Distillation." Journal of the American Society of Brewing Chemists 73, no. 1 (January 2015): 41–48. http://dx.doi.org/10.1094/asbcj-2015-0112-01.

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19

Rivera, W., R. Best, J. N. Baker, W. H. Fletcher, C. L. Heard, and F. A. Holland. "Mobile pilot-plant for the production of environmentally clean steam." Applied Thermal Engineering 17, no. 4 (April 1997): 317–26. http://dx.doi.org/10.1016/s1359-4311(96)00049-x.

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20

Chandak, Nilesh, Abraham George, Adel Al Hamadi, and Mikael Berthod. "Optimization of hydrocracker pilot plant operation for Base Oil production." Catalysis Today 271 (August 2016): 199–206. http://dx.doi.org/10.1016/j.cattod.2015.09.052.

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21

Kloosterman, J., and M. D. Lilly. "Pilot-plant production of prednisolone using calcium alginate immobilizedArthrobacter simplex." Biotechnology and Bioengineering 28, no. 9 (September 1986): 1390–95. http://dx.doi.org/10.1002/bit.260280913.

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22

Manikandan, V. "PILOT PLANT SCALE-UP STUDIES FOR PARENTERAL - A REVIEW." International Research Journal Of Pharmacy 12, no. 8 (August 31, 2021): 58–63. http://dx.doi.org/10.7897/2230-8407.1208158.

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The dosage form of parenteral is sterile and gives a quick beginning of activity and gives an immediate action to accomplishing the medication impact inside the body. The route of parenteral administration is the most well-known and productive route for the conveyance of dynamic medication substances with poor bioavailability and medications with a tight therapeutic index. The principal objective of the technique was to endeavour to talk about the different procedures needed for the pilot plant production considers. The pilot plant is the term that is normally more modest than large-scale production plants yet it is the underlying scope of sizes. It is planned for learning, and making the definitions on a limited scale to accomplish the relationship with the enormous scope production, and they are normally more adaptable perhaps to the detriment of the economy. Most of the pilot plants are implicit in the maker's own research centres of the manufacturer utilizing stock lab hardware. These pilot plant studies are performed by using a technology transfer (TT) documentation report which is made by the research and development department for product development. Hence, this process would meet product quality, safety, and efficacy and further this production techniques will transfer to large-scale production for parenteral preparation.

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23

Niknejad, Azadeh. "Plant-based expression systems for protein and antimicrobial peptide production." Nova Biologica Reperta 5, no. 3 (December 1, 2018): 262–73. http://dx.doi.org/10.29252/nbr.5.3.262.

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24

Gori, R., and C. Lubello. "Pilot plant for reclaimed wastewater reuse in nurseries." Water Science and Technology 42, no. 1-2 (July 1, 2000): 221–26. http://dx.doi.org/10.2166/wst.2000.0317.

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In this paper, after a brief introduction on irrigation wastewater reuse, we take a closer look at Pistoia, the most important nursery area in Italy, which specializes in production of woody ornamental plants. Groundwater resources are used for irrigation in competition with urban use, causing serious shortage problems in summer. Treated municipal wastewater can be a good alternative source of water and fertilizer nutrients for ornamental plant production. During 1998, we carried out an experiment along with local corporate bodies to evaluate the effects of Pistoia's wastewater treatment plant (WWTP) effluent irrigation of the (Pistoia) area – compared with traditional well water irrigation – on three container-grown species, each of them characterized by different growth habits. Plants irrigated with the effluent, treated with UV irradiation in a disinfection pilot plant, showed better physiological and growth parameters than those irrigated with traditional well water.

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25

Moulton, T. P., L. J. Borowitzka, and D. J. Vincent. "The mass culture of Dunaliella salina for ?-carotene: from pilot plant to production plant." Hydrobiologia 151-152, no. 1 (September 1987): 99–105. http://dx.doi.org/10.1007/bf00046114.

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26

Bundó, Mireia, Laura Montesinos, Esther Izquierdo, Sonia Campo, Delphine Mieulet, Emmanuel Guiderdoni, Michel Rossignol, et al. "Production of cecropin A antimicrobial peptide in rice seed endosperm." BMC Plant Biology 14, no. 1 (2014): 102. http://dx.doi.org/10.1186/1471-2229-14-102.

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27

Ayoola, A. A., E. E. Alagbe, and T. A. Makinwa. "Pilot Plant Design of 1kg Biodiesel Production using Waste Soybean Oil." IOP Conference Series: Earth and Environmental Science 655, no. 1 (February 1, 2021): 012052. http://dx.doi.org/10.1088/1755-1315/655/1/012052.

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28

Igboanugo, A. C., and S. Amiebenomo. "Design of Process Layout for a Pilot Alkyd Resin Production Plant." Advanced Materials Research 18-19 (June 2007): 435–41. http://dx.doi.org/10.4028/www.scientific.net/amr.18-19.435.

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There are several reasons why industrial engineers need to optimize process layout designs. This paper points out the justification and discusses the qualitative and quantitative techniques involved in the determination of an optimal process layout for a pilot alkyd resin and its end products manufacturing system. It also spotlights practical decisions required for achieving optimality in the design process. It is the belief of the authors that with some improvements on the final layout, our proposed layout will be a ballpark of eco-factory moored on green manufacturing.

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29

Martosuyono, Pujoyuwono, Yusro Nuri Fawzya, Gintung Patantis, and Sugiyono Sugiyono. "Enzymatic Production of Fish Protein Hydrolysates in A Pilot Plant Scale." Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology 14, no. 2 (August 30, 2019): 85. http://dx.doi.org/10.15578/squalen.v14i2.398.

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Protease enzyme produced from Bacillus sp was employed to hydrolyze fish protein hydrolysates (FPH) under controlled conditions at a batch-pilot plant scale-process. Thirty kilograms of fish meat was mincedand mixed with 60 liters of water in 100 liters stainless steel vessel and 20,000 units of protease enzyme was added per kg of fish. Hydrolysis of fish was carried out at 55 oC for 6 hours. Multi stage of filtration were done to separate the FPH from unhydrolized fish residue. Mass balance were carried out to determine the rate of hydrolysis and yields. W ithout pH adjustment, 80% of substrate hydrolyzed could be achieved in 6 hour at 55 °C. Three kinds of products were recovered from the process, i.e solid residue, liquid FPH as filtration product, and spray dried FPH. Hydrolysis of 30 kg of fish meat substrate producing 1.7-2.0 kg of unhydrolyzed residue and 70 L of liquid FPH. Afterspray drying process of liquid FPH, 13 kg of FPH powder was recovered. The proximate and amino acid analysis of spray dried FPH showed that the FPH containing 20% of protein, rich in amino acids especially lysine and leucineand the residue still had 85,36% of protein (dry basis) that could be utilized for other purpose.

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30

Kerboua Ziari, Yasmina, Lotfi Ziani, and Ahmed Benzaoui. "Dimensionning and Simulation of a Pilot Plant for Solar Hydrogen Production." Advanced Materials Research 314-316 (August 2011): 1857–60. http://dx.doi.org/10.4028/www.scientific.net/amr.314-316.1857.

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Keywords: Hydrogen, Solar, Hydrogen Production, Electrolysis, Photovoltaic Panel, Simulation Abstract. Hydrogen is regarded as the potential bearer of energy of the future. Solar hydrogen is the hydrogen produced using renewable energy, particularly solar energy [8,3]. The availability of water and hours of sunshine make Algeria a place of choice for solar hydrogen production. In this work, solar hydrogen production by electrolysis of water is considered. The required energy for water dissociation is supplied by a photovoltaic system. A design and operation study of a photovoltaic system has been done for three different regions in Algeria. The production potential is highly significant particularly in the south parts of this country.

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31

Ajiwe, V. I. E., C. A. Okeke, S. C. Ekwuozor, and I. C. Uba. "A pilot plant for production of ceiling boards from rice husks." Bioresource Technology 66, no. 1 (October 1998): 41–43. http://dx.doi.org/10.1016/s0960-8524(98)00023-6.

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32

Colombo, A. P., S. Briançon, J. Lieto, and H. Fessi. "Project, Design, and Use of a Pilot Plant for Nanocapsule Production." Drug Development and Industrial Pharmacy 27, no. 10 (January 2001): 1063–72. http://dx.doi.org/10.1081/ddc-100108369.

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33

Andresen, Bjørg, Arnstein Norheim, Jon Strand, Øystein Ulleberg, Arild Vik, and Ivar Wærnhus. "BioZEG – Pilot Plant Demonstration of High Efficiency Carbon Negative Energy Production." Energy Procedia 63 (2014): 279–85. http://dx.doi.org/10.1016/j.egypro.2014.11.030.

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34

Sahu, Gajanan, L. M. Das, B. K. Sharma, and S. N. Naik. "Pilot plant study on biodiesel production from Karanja and Jatropha oils." Asia-Pacific Journal of Chemical Engineering 6, no. 1 (January 2011): 38–43. http://dx.doi.org/10.1002/apj.443.

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35

Kim, Kyeongsu, Woong Hee Lee, Jonggeol Na, YunJeong Hwang, Hyung-Suk Oh, and Ung Lee. "Data-driven pilot optimization for electrochemical CO mass production." Journal of Materials Chemistry A 8, no. 33 (2020): 16943–50. http://dx.doi.org/10.1039/d0ta05607c.

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36

Sasongko, Nugroho, Ryozo Noguchi, Junko Ito, Mikihide Demura, Sosaku Ichikawa, Mitsutoshi Nakajima, and Makoto Watanabe. "Engineering Study of a Pilot Scale Process Plant for Microalgae-Oil Production Utilizing Municipal Wastewater and Flue Gases: Fukushima Pilot Plant." Energies 11, no. 7 (June 28, 2018): 1693. http://dx.doi.org/10.3390/en11071693.

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37

Weisenburger, Gerald A., D. Keith Anderson, Jerry D. Clark, Albert D. Edney, Puneh S. Karbin, Donald J. Gallagher, Carl M. Knable, and Mark A. Pietz. "Pilot-Plant Preparation of an αvβ3Integrin Antagonist: Process Development of a Carbonyldiimidazole Peptide Coupling." Organic Process Research & Development 13, no. 1 (January 16, 2009): 60–63. http://dx.doi.org/10.1021/op8002213.

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38

ISMAIL, ISMAFATIN NABILAH, SHAHRUL ISMAIL, and MOHAMED SHAHRIR MOHAMED ZAHARI. "MICROBIAL COMMUNITY PROFILING OF DIGESTED SLUDGE FROM PILOT PLANT BIO-DIGESTER." Universiti Malaysia Terengganu Journal of Undergraduate Research 3, no. 3 (July 31, 2021): 53–60. http://dx.doi.org/10.46754/umtjur.v3i3.217.

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The production of biogas involves different microbial groups working in a synchronously and closely interactive manner. In Malaysia, biogas production from food waste is an encouraging alternative for sustainable energy production. Therefore, to better understand and optimize process, identification of the microbial community involved in anaerobic digestion (AD) is essential. The purpose of this study is to identify the microbial characteristics under different AD conditions to establish the links between microbial community structure and operational condition efficiency. The pilot plant bio-digester production performance will be determined by analysis of Chemical Oxygen Demand (COD) removal efficiency for 43 days. Next, when the performance of the digester has achieved an optimum level of removal efficiency, a sample of digested sludge will be taken for further analysis of microbial community profiling by undergo DNA extraction, amplifying DNA and Next Gene Sequencing (NGS) technology. The results show that the COD removal efficiency at an optimum level is 93%, while the percentage of methane gas composition inside the digester is 69%, indicating a very high efficiency for the digester. Thus, the lower the concentration of COD effluent, the higher the concentration of COD removal efficiency. Besides, an optimum an optimum level of COD removal efficiency indicates active microbial activities inside the bio-digester. Furthermore, the microbial community structure with operational conditions at various states of anaerobic digestion is summarizing. These findings are important as microbial characteristics of digested sludge is important to manage and optimize biogas production.

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39

Endo, Hisashi, Yoshikazu Nagayoshi, and Kenji Suzuki. "Production of glass ceramics from sewage sludge." Water Science and Technology 36, no. 11 (December 1, 1997): 235–41. http://dx.doi.org/10.2166/wst.1997.0416.

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Environmental problems are a worldwide concern. So recycling with a zero-emission objective is being pursued. For this purpose, a melting process whereby sludge was converted into slag has been developed and commercialized. However, as the glass material of conventional slag is inferior compared to natural stone, the use of slag as a substitute material has been limited. Therefore, glass ceramics technology was studied to produce crystallized glass from sewage sludge. The technology was researched and developed jointly with the Tokyo Metropolitan Government in pursuing the basic study and pilot plant studied from 1991 to 1995. As a result, we have successfully commercialized this technology to convert sewage sludge into a resource as stone-like products, followed successfully by a long pilot operation. Now the commercialized plant of 150 ton-cake/day was installed and has been producing stone products from sewage sludge since 1996. In this paper, we report the results of the latest pilot plant test, and the application study of stone products for recycling use as well. For long decades, we obtain building materials from mountains and forests then built up metropolis. Then the metropolis exhaust waste and surrounding environment is polluted. We are convinced that this technology may contribute to prevent such environmentally unbalanced cycle.

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40

Sallee, Nathan A., Ernestine Lee, Atossa Leffert, Silvia Ramirez, Arthur D. Brace, Robert Halenbeck, W. Michael Kavanaugh, and Kathleen M. C. Sullivan. "A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 9 (July 25, 2020): 1047–63. http://dx.doi.org/10.1177/2472555220934807.

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The identification of novel peptide hormones by functional screening is challenging because posttranslational processing is frequently required to generate biologically active hormones from inactive precursors. We developed an approach for functional screening of novel potential hormones by expressing them in endocrine host cells competent for posttranslational processing. Candidate preprohormones were selected by bioinformatics analysis, and stable endocrine host cell lines were engineered to express the preprohormones. The production of mature hormones was demonstrated by including the preprohormones insulin and glucagon, which require the regulated secretory pathway for production of the active forms. As proof of concept, we screened a set of G-protein-coupled receptors (GPCRs) and identified protein FAM237A as a specific activator of GPR83, a GPCR implicated in central nervous system and regulatory T-cell function. We identified the active form of FAM237A as a C-terminally cleaved, amidated 9 kDa secreted protein. The related protein FAM237B, which is 64% homologous to FAM237A, demonstrated similar posttranslational modification and activation of GPR83, albeit with reduced potency. These results demonstrate that our approach is capable of identifying and characterizing novel hormones that require processing for activity.

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41

Tanaka, N., and T. Hvitved-Jacobsen. "Sulfide production and wastewater quality – investigations in a pilot plant pressure sewer." Water Science and Technology 43, no. 5 (March 1, 2001): 129–36. http://dx.doi.org/10.2166/wst.2001.0268.

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The relationship linking sulfide production rate and wastewater quality in terms of its biodegradability was studied using a pilot plant pressure sewer (inner diameter: 102 mm, length: 47 m). Furthermore, anaerobic transformations of wastewater organic matter were investigated. Wastewater characterization based on oxygen utilization rate (OUR) measurements and VFA analyses was employed. As wastewater quality parameters essential for the sulfide production, COD components and dissolved carbohydrate were focused on. Readily biodegradable substrate and fermentable, readily biodegradable substrate were better parameters than traditional dissolved COD for the prediction of sulfide production rates in a pressure sewer. From the results obtained, it was possible to integrate the sulfide production process with the transformation processes of wastewater organic matter in pressure sewers.

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Ippoliti, Davide, Alicia González, Ismael Martín, José M. Fernández Sevilla, Rossella Pistocchi, and F. Gabriel Acién. "Outdoor production of Tisochrysis lutea in pilot-scale tubular photobioreactors." Journal of Applied Phycology 28, no. 6 (April 28, 2016): 3159–66. http://dx.doi.org/10.1007/s10811-016-0856-x.

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Silva, Tiago de Oliveira, Leizer Schnitman, Delano Mendes De Santana, Patrick Souza Lima, Leonardo Silva De Souza, and Marcos Fabio De Jesus. "Fluid dynamic analysis In an petroleum production pilot plant using computational Tools." Rio Oil and Gas Expo and Conference 22, no. 2022 (September 26, 2022): 16–17. http://dx.doi.org/10.48072/2525-7579.rog.2022.016.

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44

Desikan, P. S. "Pilot Plant Experiments on an Improved Electrolytic Cell for Magnesium Metal Production." Key Engineering Materials 8 (January 1985): 217–24. http://dx.doi.org/10.4028/www.scientific.net/kem.8.217.

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45

Landers, Jay. "Pilot Plant Used to Evaluate Algae for Wastewater Treatment and Biofuel Production." Civil Engineering Magazine Archive 82, no. 4 (April 2012): 40–41. http://dx.doi.org/10.1061/ciegag.0000640.

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46

Wieckert, C., U. Frommherz, S. Kräupl, E. Guillot, G. Olalde, M. Epstein, S. Santén, T. Osinga, and A. Steinfeld. "A 300kW Solar Chemical Pilot Plant for the Carbothermic Production of Zinc." Journal of Solar Energy Engineering 129, no. 2 (March 29, 2006): 190–96. http://dx.doi.org/10.1115/1.2711471.

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In the framework of the EU-project SOLZINC, a 300-kW solar chemical pilot plant for the production of zinc by carbothermic reduction of ZnO was experimentally demonstrated in a beam-down solar tower concentrating facility of Cassegrain optical configuration. The solar chemical reactor, featuring two cavities, of which the upper one is functioning as the solar absorber and the lower one as the reaction chamber containing a ZnO/C packed bed, was batch-operated in the 1300–1500 K range and yielded 50 kg/h of 95%-purity Zn. The measured energy conversion efficiency, i.e., the ratio of the reaction enthalpy change to the solar power input, was 30%. Zinc finds application as a fuel for Zn/air batteries and fuel cells, and can also react with water to form high-purity hydrogen. In either case, the chemical product is ZnO, which in turn is solar-recycled to Zn. The SOLZINC process provides an efficient thermochemical route for the storage and transportation of solar energy in the form of solar fuels.

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Degiorgis, L., M. Santarelli, and M. Calì. "Hydrogen from renewable energy: A pilot plant for thermal production and mobility." Journal of Power Sources 171, no. 1 (September 2007): 237–46. http://dx.doi.org/10.1016/j.jpowsour.2007.01.060.

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Botes, J. P., E. P. Jacobs, and S. M. Bradshaw. "Long-term evaluation of a UF pilot plant for potable water production." Desalination 115, no. 3 (August 1998): 229–38. http://dx.doi.org/10.1016/s0011-9164(98)00042-3.

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Bouaid, Abderrahim, Yolanda Diaz, Mercedes Martinez, and Jose Aracil. "Pilot plant studies of biodiesel production using Brassica carinata as raw material." Catalysis Today 106, no. 1-4 (October 2005): 193–96. http://dx.doi.org/10.1016/j.cattod.2005.07.163.

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Visitserngtrakul, S., K. Kirtikara, N. Thavarungkul, C. Koompai, P. Monthachitara, and C. M. Lampert. "Pilot plant production of black chrome in Thailand: from science to technology." Solar Energy Materials 21, no. 1 (November 1990): 1–16. http://dx.doi.org/10.1016/0165-1633(90)90038-3.

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