Relevant bibliographies by topics / Pediatric sleep

Academic literature on the topic 'Pediatric sleep'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Pediatric sleep"

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VENTIS, DEBORAH G., and DEBORAH FOSS-GOODMAN. "Overinterpreting Sleep Problems." Pediatrics 78, no. 3 (September 1, 1986): 548. http://dx.doi.org/10.1542/peds.78.3.548a.

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To the Editor.— We write in regard to the article, "Sleep Problems Seen in Pediatric Practice," by Lozoff et al (Pediatrics 1985; 75:477-483). Overinterpretation of problems that may be typical of development in young children is a pitfall in developmental-behavioral pediatrics which can be the result, in part, of methodologic and statistical inadequacies. Two of the most serious problems that may occur are use of designs that do not provide a direct test of the theoretical question(s) posed and speculation about causality where causal ordering cannot be determined.
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Carbone, Tracy. "Pediatric Sleep Medicine." Pediatric Annals 46, no. 9 (September 1, 2017): e319-e320. http://dx.doi.org/10.3928/19382359-20170815-04.

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Ievers-Landis, Carolyn E., and Susan Redline. "Pediatric Sleep Apnea." American Journal of Respiratory and Critical Care Medicine 175, no. 5 (March 2007): 436–41. http://dx.doi.org/10.1164/rccm.200606-790pp.

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Brooks, L. J. "Pediatric Sleep Medicine." Neurology 43, no. 5 (May 1, 1993): 1062. http://dx.doi.org/10.1212/wnl.43.5.1062-a.

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Maski, Kiran, and Judith Owens. "Pediatric Sleep Disorders." CONTINUUM: Lifelong Learning in Neurology 24, no. 1 (February 2018): 210–27. http://dx.doi.org/10.1212/con.0000000000000566.

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Tan, Hui-Leng, and Maria Villa. "Pediatric Sleep Medicine." Journal of Pediatric Biochemistry 06, no. 04 (May 19, 2017): 159. http://dx.doi.org/10.1055/s-0037-1603323.

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Capp, Philip K., Phillip L. Pearl, and Daniel Lewin. "Pediatric Sleep Disorders." Primary Care: Clinics in Office Practice 32, no. 2 (June 2005): 549–62. http://dx.doi.org/10.1016/j.pop.2005.02.005.

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Bhattacharjee, Rakesh, and David Gozal. "Pediatric Sleep Apnea." Chest 139, no. 5 (May 2011): 977–79. http://dx.doi.org/10.1378/chest.10-2803.

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Durmer, Jeffrey S., and Ronald D. Chervin. "PEDIATRIC SLEEP MEDICINE." CONTINUUM: Lifelong Learning in Neurology 13 (June 2007): 153–200. http://dx.doi.org/10.1212/01.con.0000275610.56077.ee.

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Carpenter, Johanna. "Pediatric Sleep Problems." Journal of Developmental & Behavioral Pediatrics 38, no. 1 (January 2017): 11. http://dx.doi.org/10.1097/dbp.0000000000000332.

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Dissertations / Theses on the topic "Pediatric sleep"

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Chambers, Danielle. "An Exploration of the Referral Behaviors of Pediatric Medical Professionals for Pediatric Behavioral Disordered Sleep." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2338.

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Disordered sleep affects 20-40% of children and adolescents. Such disorders can result in academic difficulties, emotional regulation difficulties, and decreased immune system functioning. Behavioral treatments are the empirically supported treatment for pediatric sleep problems. With most children getting yearly well-child visits, pediatric medical professionals are in an optimal position to identify sleep difficulties and refer children for treatment. However, research suggests that medical professionals receive limited formal education in disordered sleep, and they more frequently recommend medication over behavioral interventions. Therefore, referrals to psychologists for behavioral treatments may often be warranted. The factors that influence medical professionals’ referral decisions have not been investigated. The current study investigated factors implicated in referral behaviors including pediatric medical professionals’ knowledge, screening patterns, treatment preferences, and referral patterns in the area of pediatric behavioral disordered sleep. A total of 65 medical professionals were recruited to complete an online survey to investigate these factors. Results indicated that participants in the current study demonstrated significantly higher sleep knowledge and rates of screening than what was found in a previous study. Regarding predictors of sleep knowledge, taken together, specialty, years in practice, and screening behaviors significantly predicted sleep knowledge scores. Additionally, sleep knowledge of participants who indicated that a referral was necessary when presented with a hypothetical case example of a child presenting with disordered sleep was significantly lower than the sleep knowledge of those who did not refer. Further, rates of referral were significantly lower than reported in previous research. Confidence in managing sleep problems and rates of providing behavioral recommendations were also explored. Overall, results of the current study indicate that pediatric medical professionals may benefit from additional training in the area of pediatric behavioral sleep and increased awareness of appropriate referral sources. Further exploration into the influence of screening behaviors and treatment preferences on referral behavior is necessary.
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Polaha, Jodi. "The Management of Common Sleep Problems in Pediatric Primary Care." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/6694.

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Campbell, Leah Catherine. "Exploring Differences in Pediatric and Adult Sleep: Two Mathematical Investigations." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338312080.

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Cronly, Jo. "Development of a Simplified Pediatric Obstructive Sleep Apnea (OSA) Screening Tool." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3337.

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Background: Obstructive sleep apnea has become recognized as one of the most common, under-diagnosed chronic diseases. Recently studies have shown increased numbers among the pediatric and adolescent population. OSA in children is associated with behavioral problems, poor school achievements, and in severe cases, pulmonary hypertension. OSA is often the Achilles heel of pediatric sedation and analgesic programs; during sedation, children with OSA have an increased vulnerability of their airway undergoing pharyngeal collapse and of having upper airway obstruction. Consequently, pediatric dentists who practice sedation dentistry should exercise extra precautions when treating patients with risk of sleep apnea. Currently there is no screening tool used in pediatric dentistry for diagnosing OSA during the pre-operative appointment or consultation for patients undergoing minimal and moderate oral conscious sedation. The purpose of this study was to develop and test a concise and easy-to-use questionnaire as a screening tool to aid in the diagnosis of OSA in pediatric patients. Materials and Methods: A retrospective chart review of 180 patients under the age of 18, who completed a polysomnogram at the VCU Center for Sleep Medicine between February 2011 and February 2013. A validated adult questionnaire, STOPBANG, was modified using more typical pediatric risk factors for OSA: presence of snoring (S), tonsillar hypertrophy (T1), tiredness; pESS>10 (T2), observed obstruction (O), neuroPsych-behavioral symptoms such as ADHD or daytime irritability (P), BMI percentile for age (B), age at diagnostic screening (A), presence of neuromuscular disorder (N), and presence of genetic/congenital disorder (G). A positive scoring from these variables was measured against the standard OSA measure, Apnea-Hypopnea Index. A multiple logistic regression analysis tested for relationships. Results: There was a statistically significant relationship P= .0007 for the S(T1)OPBANG scale, with a minimum of 4 variables needed to have a sensitivity of 57% and a specificity of 78%. There was also a statistically significant relationship P= .0040 for the S(T2)OPBANG, the cutoff>5 yielding sensitivity=36%, and specificity=90%. Only obstruction, BMI, and age showed a strong significant relationship to OSA. The presence of an obstruction was positively related to apnea (P = 0.0010). Most of the other components had an odds-ratio larger than one (indicating a nominally positive relationship). Conclusions: While both STOPBANG screening tools showed a statistically significant relationship, only obstruction, BMI, and age showed a predictive relationship to OSA. Consequently, consideration of other risk factors may be beneficial for future studies.
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French, Rachel B. "Health and behavioral problems associated with symptoms of pediatric sleep disorders." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002767.

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Burns, Lisa A. "Ambulatory Blood Pressure And Cardiac Remodeling After Adenotonsillectomy In Pediatric Sleep Apnea." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384334242.

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Selvganesan, Padmini. "Smart Statistics, Signal Processing and Instrumentation for Improved Diagnosis of Pediatric Sleep Apnea." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron159550472185963.

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Chambers, Danielle Elizabeth. "BRIEF INTERVENTION TO ADDRESS BEHAVIORAL DISORDERED SLEEP: EXAMINING FACTORS RELATED TO INTERVENTION EFFICACY." OpenSIUC, 2021. https://opensiuc.lib.siu.edu/dissertations/1953.

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Sleep disorders are highly prevalent in children and adolescents, affecting approximately 25-40% of this population. Questions about sleep are among the most frequent concerns that parents raise to their child’s pediatric medical provider. Behavioral treatments are the empirically supported treatments for addressing behavioral disordered sleep, and pediatric medical providers often endorse using such strategies. However, given the time constraints of primary care visits, such strategies are delivered in a very brief format. Whether or not these recommendations result in a change in the child’s disordered sleep symptoms has not been explored. Further, it is likely that this brief recommendation format is effective for some patients but not others. For example, children with comorbid neurodevelopmental conditions, severe sleep problems, and anxiety are less likely to respond to brief sleep interventions, and, therefore, may require a more comprehensive, time-intensive behavioral intervention. The current study aimed to explore factors related to the efficacy of a brief behavioral intervention provided via telehealth. Thirteen parents completed all portions of the study. Three were parents of children between the ages of 8 to 15 years and 10 were parents of children between the ages of 4 to 7 years (M = 6.8; SD = 2.7). All parents identified as White mothers. All children were also identified as White with 38.5% being female. Due to small sample size, quantitative analyses were not appropriate, so a qualitative examination of the data was conducted to explore relationships among participant demographics, sleep hygiene behaviors, sleep knowledge, sleep symptom severity, anxiety symptoms, and effects of the intervention. Results indicated that 37.50% of parents accurately assessed whether their child had problematic sleep. Minor variations in sleep knowledge were observed between parents who accurately identified their child’s sleep problems and those who did not (7.67 and 6.40 out of 10, respectively). Overall, participants had an average initial sleep knowledge score of 6.68, an average follow up sleep knowledge score of 7.31, and an average change in knowledge score of 0.62. Regarding effects of the intervention on sleep symptom severity, the average initial sleep symptom severity score was 50.25, the average follow up sleep severity score was 48.77, and the average change in sleep severity score was -2.00. An examination of sleep hygiene characteristics highlighted that while 81.25% of participants endorsed having a bedtime routine, almost 70% reported that the routine included an electronic device. Differences in initial sleep symptom severity and sleep knowledge scores were noted between participants who did and did not include electronic devices in their bedtime routines. The clinical implications of these findings are discussed further. Differences in intervention efficacy between participants with and without ADHD was also examined, but differences were not apparent. Intervention acceptability and feasibility were also examined. The current study demonstrated that the intervention was feasible to deliver for most participants within 10 minutes and, therefore, would be conducive to a primary care setting. Additionally, parents reported high levels of satisfaction with the content, understandability, and comprehensiveness of the treatment, which is encouraging for parents’ willingness to utilize the intervention if it was available to them. This study acted as an important initial step to determining the feasibility and acceptability of a brief behavioral sleep intervention. Clinical implications and future directions are discussed.
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Huss, Debra B. "Comorbidity of pediatric migraine and sleep disturbances the role of a dysfunctional autonomic nervous system /." Lexington, Ky. : [University of Kentucky Libraries], 2007. http://hdl.handle.net/10225/766.

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Thesis (Ph. D.)--University of Kentucky, 2007.
Title from document title page (viewed on March 18, 2008). Document formatted into pages; contains: vii, 48 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 37-45).
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Huss, Debra B. "COMORBIDITY OF PEDIATRIC MIGRAINE AND SLEEP DISTURBANCES: THE ROLE OF A DYSFUNCTIONAL AUTONOMIC NERVOUS SYSTEM." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/582.

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This study compared psychological and physiological differences between children diagnosed with migraine and their healthy peers. Physiological measures were obtained at baseline, after discussing an emotionally relevant stressor, and after recovery in 21 children with pediatric migraine and 32 healthy peers. Comparisons were also made on psychological measures investigating sleep problems, anxiety, and family stress. It was hypothesized that children with migraine compared to their peers 1) would report more sleep disturbances, anxiety, and family stress 2) would exhibit greater sympathetic activation at rest, in response to an emotional stressor, and after a recovery period and 3) that autonomic functioning would mediate the relation between the presence of pediatric migraine and sleep disturbances. Results indicated that the migraine group reported significantly greater anxiety compared to peers but there were no significant differences in sleep disturbances or family stress. Within the migraine group, migraine severity was significantly associated with total sleep disturbance and greater incidence of parasomnias, while migraine duration was significantly associated with greater night time awakenings. Migraine children also exhibited a significantly higher pulse rate compared to their peers at rest and a significantly higher diastolic blood pressure and marginally significant higher LF/HF ratio at recovery from an emotional stressor. These findings suggest that sleep disturbance and pediatric migraine are significantly related but the relation is unclear and warrants additional research. Results also indicate that children with migraine may experience more anxiety than peers. Of most interest, results suggest that children with migraine may experience a disinhibition of the autonomic nervous system characterized by a dominance of the sympathetic nervous system resulting in a longer recovery period following an emotional stressor.
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Books on the topic "Pediatric sleep"

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Jean-Paul, Spire, and Levy Howard B, eds. Pediatric sleep medicine. Philadelphia: Saunders, 1992.

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Gozal, David, and Leila Kheirandish-Gozal, eds. Pediatric Sleep Medicine. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65574-7.

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Carr, Michele M. Pediatric obstructive sleep apnea. Alexandria, VA: American Academy Of Otolaryngology--Head and Neck Surgery Foundation, 2007.

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Liem, Edmund, ed. Sleep Disorders in Pediatric Dentistry. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13269-9.

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Mindell, Jodi A. A clinical guide to pediatric sleep: Diagnosis and management of sleep problems. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2009.

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Durand, Vincent Mark. When children don't sleep well: Interventions for pediatric sleep disorders : parent workbook. New York: Oxford University Press, 2008.

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Durand, Vincent Mark. When children don't sleep well: Interventions for pediatric sleep disorders : therapist guide. Oxford: Oxford University Press, 2008.

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Anna, Ivanenko, ed. Pediatric sleep disorders / guest editors, Jess P. Shatkin, Anna Ivanenko. Philadelphia, Pa: Saunders, 2009.

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Meltzer, Lisa J., and Valerie McLaughlin Crabtree. Pediatric sleep problems: A clinician's guide to behavioral interventions. Washington: American Psychological Association, 2015. http://dx.doi.org/10.1037/14645-000.

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Judd, Sandra J. Sleep disorders sourcebook: Basic consumer health information about sleep disorders, including insomnia, sleep apnea and snoring, jet lag and other circadian rhythm disorders, narcolepsy, and parasomnias, such as sleepwalking and sleep paralysis, and featuring facts about other health problems that affect sleep, why sleep is necessary, how much sleep is needed, the physical and mental effects of sleep deprivation, and pediatric sleep issues, along with tips for diagnosing and treating sleep disorders. 3rd ed. Detroit, MI: Omnigraphics, 2010.

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Book chapters on the topic "Pediatric sleep"

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Hiestand, David M. "Pediatric Sleep I." In Primary Care Sleep Medicine, 191–97. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-421-6_17.

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Hiestand, David M. "Pediatric Sleep II." In Primary Care Sleep Medicine, 199–208. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-421-6_18.

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Shalini, Paruthi. "Pediatric Sleep Medicine." In Sleep Medicine in Neurology, 153–64. Oxford: John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118764152.ch15.

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Byrd, Michelle, Casiana Warfield, and Lauren Ostarello. "Pediatric Sleep Resistance." In Principle-Based Stepped Care and Brief Psychotherapy for Integrated Care Settings, 327–36. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70539-2_29.

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Ross, Kristie R., and Carol Rosen. "Pediatric Sleep Medicine." In Competencies in Sleep Medicine, 307–23. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9065-4_17.

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Bruni, Oliviero, and Marco Angriman. "Pediatric Insomnia." In Sleep Disorders in Children, 155–84. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28640-2_9.

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Griebel, May L., and Linda K. Moyer. "Pediatric Polysomnography." In Sleep: A Comprehensive Handbook, 977–87. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471751723.ch129.

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Awaad, Yasser M. "Sleep Disorders." In Absolute Pediatric Neurology, 623–41. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78801-2_23.

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Verhulst, Stijn. "Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity." In Pediatric Obesity, 241–52. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-60327-874-4_17.

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Wuertz, Karen, Aaron Glick, Jerald Simmons, and Emily Hansen-Kiss. "Pediatric Obstructive Sleep Medicine." In Dental Sleep Medicine, 365–401. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-10646-0_14.

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Conference papers on the topic "Pediatric sleep"

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Corrêa, C. D. C., A. L. F. Garcia, E. D. P. Ranzani, and S. A. T. Weber. "Pediatric tracheostomy: how real is decannulation?" In Sleep and Breathing 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/23120541.sleepandbreathing-2021.59.

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Hua, Alexandra, Tammy Pham, Cara Jacobson, Chuck Ng, and Ruth Milanaik. "Examining Sleep Habits of Pediatric Residents: Accumulating Sleep Debt." In Selection of Abstracts From NCE 2016. American Academy of Pediatrics, 2018. http://dx.doi.org/10.1542/peds.141.1_meetingabstract.112.

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Zancanella, E., C. D. C. Corrêa, A. J. Machado Júnior, M. T. Bussi, L. D. Campos, and S. A. T. Weber. "Consensus strategies for diagnosis and management of pediatric osa in brazil: pilot report." In Sleep and Breathing 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/23120541.sleepandbreathing-2021.61.

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Deng, Zhi-De, Chi-Sang Poon, Natalia M. Arzeno, and Eliot S. Katz. "Heart Rate Variability in Pediatric Obstructive Sleep Apnea." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.260139.

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Deng, Zhi-De, Chi-Sang Poon, Natalia M. Arzeno, and Eliot S. Katz. "Heart Rate Variability in Pediatric Obstructive Sleep Apnea." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4398217.

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Chocano, J. Francisco, and Carlos S. Sendon. "Obstructive Sleep Apnea Syndrome In Overweight Pediatric Patients." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3713.

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Ignatiuk, D. A., K. Miles, M. Cash, N. Gurbani, R. Hirsch, M. Magness, and N. Simakajornboon. "Prevalence of Sleep Disordered Breathing and Other Sleep Disorders in Pediatric Patients with Pulmonary Hypertension." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3350.

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"Modeling and Simulation for pediatric sleep and education performance correlations." In 2016 Spring Simulation Multi-Conference. Society for Modeling and Simulation International (SCS), 2016. http://dx.doi.org/10.22360/springsim.2016.msm.015.

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Lugo-Ramos, L. E., M. Collazo-Roman, D. De Sola, and W. De Jesus-Rojas. "Case Series: Pediatric Sleep-Disordered Breathing in Rare Genetic Disorders." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3481.

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Rodrigues, Jorge M., M. Helena Estevao, Jose Luis Malaquias, Paulo Santos, Goncalo Gouveia, and J. Basilio Simoes. "SleepAtHome - Portable Home Based System for Pediatric Sleep Apnoea Diagnosis." In 2007 IEEE International Conference on Portable Information Devices. IEEE, 2007. http://dx.doi.org/10.1109/portable.2007.62.

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Reports on the topic "Pediatric sleep"

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Forrest, Christopher, Lisa Meltzer, Carole Marcus, Anna de la Motte, Amy Kratchman, Daniel Buysse, Paul Pilkonis, Brandon Becker, and Katherine Bevans. Development of the PROMIS Pediatric Sleep Health Item Banks. Patient-Centered Outcomes Research Institute (PCORI), September 2018. http://dx.doi.org/10.25302/9.2018.me.140312211.

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Mao, Hui, YueHui Wei, Huimin Su, and Xun Li. Pediatric Tui Na for cough in children: A protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0076.

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Review question / Objective: The aim of this systematic review is to evaluate the effectiveness and safety of pediatric Tui Na in the treatment of cough in children under seven years of age. Condition being studied: Cough is essentially a protective reflex of respiratory tract to various stimuli, typically in order to clear the lung airways of fluids, mucus, or other material. Cough not only has a negative impact on children’s daily activities and sleep, but is associated with parental stress and worries. Pediatric Tui Na, a therapeutic massage based on the Chinese traditional theory of Yin and Yang, Qi and blood, acupoints and meridians, enjoys a long history and has been widely applied to the treatment of common diseases like fever, diarrhea, cough and asthma. This study aims to evaluate the effectiveness and safety of pediatric Tui Na in the treatment of cough in children.
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Treadwell, Jonathan R., Mingche Wu, and Amy Y. Tsou. Management of Infantile Epilepsies. Agency for Healthcare Research and Quality (AHRQ), October 2022. http://dx.doi.org/10.23970/ahrqepccer252.

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Objectives. Uncontrolled seizures in children 1 to 36 months old have serious short-term health risks and may be associated with substantial developmental, behavioral, and psychological impairments. We evaluated the effectiveness, comparative effectiveness, and harms of pharmacologic, dietary, surgical, neuromodulation, and gene therapy treatments for infantile epilepsies. Data sources. We searched Embase®, MEDLINE®, PubMed®, the Cochrane Library, and gray literature for studies published from January 1, 1999, to August 19, 2021. Review methods. Using standard Evidence-based Practice Center methods, we refined the scope and applied a priori inclusion criteria to the >10,000 articles identified. We ordered full text of any pediatric epilepsy articles to determine if they reported any data on those age 1 month to <36 months. We extracted key information from each included study, rated risk of bias, and rated the strength of evidence. We summarized the studies and outcomes narratively. Results. Forty-one studies (44 articles) met inclusion criteria. For pharmacotherapy, levetiracetam may cause seizure freedom in some patients (strength of evidence [SOE]: low), but data on other medications (topiramate, lamotrigine, phenytoin, vigabatrin, rufinamide, stiripentol) were insufficient to permit conclusions. Both ketogenic diet and the modified Atkins diet may reduce seizure frequency (SOE: low for both). In addition, the ketogenic diet may cause seizure freedom in some infants (SOE: low) and may be more likely than the modified Atkins diet to reduce seizure frequency (SOE: low). Both hemispherectomy/hemispherotomy and non-hemispheric surgical procedures may cause seizure freedom in some infants (SOE: low for both), but the precise proportion is too variable to estimate. For three medications (levetiracetam, topiramate, and lamotrigine), adverse effects may rarely be severe enough to warrant discontinuation (SOE: low). For topiramate, non-severe adverse effects include loss of appetite and upper respiratory tract infection (SOE: moderate). Harms of diets were sparsely reported. For surgical interventions, surgical mortality is rare for functional hemispherectomy/hemispherotomy and non-hemispheric procedures (SOE: low), but evidence was insufficient to permit quantitative estimates of mortality or morbidity risk. Hydrocephalus requiring shunt placement after multilobar, lobar, or focal resection is uncommon (SOE: low). No studies assessed neuromodulation or gene therapy. Conclusions. Levetiracetam, ketogenic diet, modified Atkins diet, and surgery all appear to be effective for some infants. However, the strength of the evidence is low for all of these modalities due to lack of control groups, low patient enrollment, and inconsistent reporting. Future studies should compare different pharmacologic treatments and compare pharmacotherapy with dietary therapy. Critical outcomes underrepresented in the literature include quality of life, sleep outcomes, and long-term development.
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