Log in

Relevant bibliographies by topics / PDGR / Dissertations / Theses

To see the other types of publications on this topic, follow the link: PDGR.

Dissertations / Theses on the topic 'PDGR'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'PDGR.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

BADIOLA, SANGA ALEXANDRA. "Study of the role of the SOX2 transcription factor in neural and mammary cancer stem cells using SOX2 conditional knock-out in mouse." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/52431.

Full text

Abstract:

The stem cell-determining transcription factor Sox2 is required for the maintenance of normal stem cells. In this study, we investigated the requirement for Sox2 in neural and breast cancer stem-like cells. In the first case, using a conditional genetic deletion mutant in a mouse model of platelet-derived growth factor-induced malignant oligodendroglioma. Taken together, our results showed that Sox2 is essential for tumor initiation by mouse pHGG cells, and we illustrated a Sox2-directed strategy of immunotherapy to eradicate tumor-initiating cells. In the second case, we used a Sox2 condition

APA, Harvard, Vancouver, ISO, and other styles

2

Eger, Glenda. "Regulation and Function of MAP Kinases in PDGF Signaling." Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-301057.

Full text

Abstract:

Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. Aberrant activation of these pathways is frequently detected in cancer. Hence, the study of these processes is essential for identifying potential drug targets or diagnostic markers. In paper I, we identified Receptor Subfamily 4 Group A Member 1 NR4A1 to be regulated by PDGF v

APA, Harvard, Vancouver, ISO, and other styles

3

Zhang, Xiao-Qun. "Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo". Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1455.

Full text

Abstract:

Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. In human tumors, such as malignant glioma, both PDGF and PDGFRα are overexpressed within the same tissue, indicating that an autocrine PDGF loop is generated in the tumors. This thesis is focused on the in vivo functionality of the PDGFRα gene (PDGFRA)

APA, Harvard, Vancouver, ISO, and other styles

4

Ma, Haisha. "Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy." Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248172.

Full text

Abstract:

Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. The first step of downregulation of PDGFR activity upon ligand binding is internalization; thus we investigated how endocytosis pathways affect PDGFR signaling. We showed that in Ras-transformed fibroblasts, the internalization of PDGFR is shifted from the routine clathrin-dependent endocytosis to macropinocytosis, which result

APA, Harvard, Vancouver, ISO, and other styles

5

Willetts, Karen Eve. "PDGF A and PDGF RÎ± in mammalian development." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318900.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois, and Maria Arantzazu Sanchez-Fernandez. "Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184120.

Full text

Abstract:

BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upr

APA, Harvard, Vancouver, ISO, and other styles

7

Hoflack, Bernard, Pierre Jurdic, Thilo Riedl, Anne Gallois, and Maria Arantzazu Sanchez-Fernandez. "Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling." PLOS one, 2008. https://tud.qucosa.de/id/qucosa%3A28994.

Full text

Abstract:

BACKGROUND: Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation. It is currently unclear whether osteoclasts can influence bone rebuilding. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cell systems, we show here that mature osteoclasts, but not their precursors, secrete chemotactic factors recognized by both mature osteoblasts and their precursors. Several growth factors whose expression is upr

APA, Harvard, Vancouver, ISO, and other styles

8

Pontén, Annica. "Biological activities of novel platelet-derived growth factors, PDGF-C and PDGF-D /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-013-3/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Kowarik, Markus. "Expression, Lokalisation und funktionelle Bedeutung von PDGF und PDGF-Rezeptoren in der Hypophyse und in Hypophysentumorzellen." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-75767.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Andræ, Johanna. "PDGF in cerebellar development and tumorigenesis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4987-5/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Etzel, Nadine. "Einfluss PDGF-Rezeptor-spezifischer Antikörper auf die Chemotaxis mesenchymaler Progenitorzellen und deren Expression von PDGF-Isoformen und -Rezeptoren." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56711.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Ekman, Simon. "Specific signaling through heteromeric PDGF receptor complexes." Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1067.

Full text

Abstract:

<p>Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. This thesis describes autophosphorylation and binding of signal transduction molecules to homo- and heterodimeric PDGF receptor complexes.</p><p> Heterodimeric PDGF receptor complexes

APA, Harvard, Vancouver, ISO, and other styles

13

Nilsson, Ingrid. "Hypoxia, PDGF and VEGF in Vascular Development." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6894.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Enarsson, Mia. "Roles of PDGF for Neural Stem Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4245.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Bahm, Isabel. "PDGF signalling during Neural Crest Cell migration." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041758/.

Full text

Abstract:

Neural crest cells are a transient cell population, which migrates through the vertebrate embryonic body, and eventually gives rise to a many different cell types in the adult. Contact inhibition of locomotion (CIL) is a fundamental property of the collective migrating neural crest cells. CIL describes a process by which colliding cells change their direction upon collision and move away from each other, which has been linked to cell dispersion, boundary formation and metastasis. CIL is acquired in neural crest cells during Epithelial-to-Mesenchymal-Transition (EMT), by a switch in the express

APA, Harvard, Vancouver, ISO, and other styles

16

Gillnäs, Sara. "PDGF-C signaling is required for normal cerebellar development : An analysis of cerebellar malformations in PDGF-C impaired mice." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445240.

Full text

Abstract:

Platelet-derived growth factor-C (PDGF-C) and its tyrosine kinase receptor PDGFRɑ have been shown to contribute to several key processes during central nervous system (CNS) development, including normal vascularization and formation of cerebral ventricles and basal membrane of the meninges. Due to redundancy between PDGF-C and PDGF-A, PDGF-C specific roles are sometimes masked and difficult to determine. Using the double mutant Pdgfc-/-;PdgfraGFP/+ mouse (Mus musculus) strain we were able to detect and examine a new, undescribed phenotype of PDGF-C impaired mice, namely cerebellar malformat

APA, Harvard, Vancouver, ISO, and other styles

17

Sjöblom, Tobias. "Paracrine and autocrine functions of PDGF in malignant disease." Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2678.

Full text

Abstract:

<p>Growth factors and their receptors are frequently activated by mutations in human cancer. Platelet-derived growth factor (PDGF)-B and its tyrosine kinase receptor, the PDGF β-receptor, have been implicated in autocrine transformation as well as paracrine stimulation of tumor growth. The availability of clinically useful antagonists motivates evaluation of PDGF inhibition in these diseases.</p><p>In chronic myelomonocytic leukemia with t(5;12), parts of the transcription factor TEL and the PDGF β-receptor are fused, generating a constitutively signaling protein. Oligomerization and unique ph

APA, Harvard, Vancouver, ISO, and other styles

18

Folestad, Erika Bergsten. "Studies of the novel PDGFs, focusing on PDGF-D /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-770-7/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Kumar, Hashethra. "Does PDGF-BB have a role in bone remodelling?" Thesis, St George's, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546797.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Qin, Yong. "Targeting the Promoter Regions of PDGF Ligand and Receptor." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194387.

Full text

Abstract:

Aberrant expression of Platelet-derived growth factor A (PDGF-A) and PDGF receptor-β (PDGFR-β) play critical roles in the angiogenesis and proliferation of several malignancies. In this dissertation I explore the transcriptional regulatory role of the Gquadruplex- forming regions in the promoters of human PDGF-A and PDGFR-β, and identify new targets for developing small molecules to modulate their expression in tumors. For PDGF-A promoter, our studies focus on two essential nuclease hypersensitive elements, NHE(PDGF-A) and 5´-end far upstream 5´-SHS. The structural aspects of the intramolecula

APA, Harvard, Vancouver, ISO, and other styles

21

Alabud, Arwa. "Proteasomens roll för ligand inducerad fragmentation av PDGF-β receptorn". Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455265.

Full text

Abstract:

Bakgrund: Platelet derived growth factor receptorn (PDGF receptorn) är en receptor i kroppen som tillhör typ III av Recetor tyrosine kinas (RTK) familjen. PDGF-β receptorn är en typ av dessa receptorer som enligt en studie klyvs i två delar efter ligandbindning med PDGF-BB ligand: till en extracellulär del och en intracellulär del. Hypotesen är att den extracellulära delen går till lysosomen medan den intracellulära delen går till proteasomen efter klyvningen. Syfte: Att undersöka rollen för proteasomen i ligandinducerad fragmentation av PDGF-β receptorn och se om det finns ko-lokalisation mel

APA, Harvard, Vancouver, ISO, and other styles

22

Higa, Thaís Tiemi. "Imunolocalização de supressores (FOXO3a e PTEN) e ativadores (Akt e phospho-Akt) da transição de folículos primordiais e primários em tecido ovariano humano." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-26042018-152648/.

Full text

Abstract:

Mulheres com risco de falência ovariana prematura, assim como aquelas diagnosticadas com câncer que desejam preservar sua fertilidade, têm como opção a criopreservação do tecido ovariano. Esse tecido seria destinado, dependendo do caso, ao reimplante posterior ou para o cultivo in vitro de folículos ovarianos isolados do tecido criopreservado. Nesse contexto, os folículos primordiais são uma população importante tanto por serem mais resistentes ao processo de criopreservação, como por representarem cerca de 90% da população total folicular. Porém o uso destes folículos para procedimentos de Re

APA, Harvard, Vancouver, ISO, and other styles

23

Valdivia, Maria Alejandra Medina. "Efeitos do PDGF-BB na taxa de proliferação e na adesão de células derivadas da granulação óssea a fragmentos radiculares." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/25/25146/tde-11062018-185848/.

Full text

Abstract:

O objetivo deste estudo foi investigar o papel do fator de crescimento derivado de plaquetas-BB (PDGF-BB) na concentração de 300ng/ml na taxa de proliferação e adesão de células derivadas da granulação óssea humana a fragmentos radiculares periodontalmente comprometidos. Na primeira etapa do estudo, foi estabelecida cultura primária de células da granulação óssea de dois pacientes adultos, sistemicamente saudáveis, não fumantes. Após a expansão celular, as células foram caracterizadas para determinação do fenótipo por meio de ensaios de viabilidade celular, MTT, ensaio de atividade de fosfatas

APA, Harvard, Vancouver, ISO, and other styles

24

Watts, Susan Margaret. "Inhibition of neointima formation using the human saphenous vein organ culture model." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264064.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Vaillant, Pierre. "La platelet-derived growth factor : son role dans la fibrose pulmonaire idiopathique." Nancy 1, 1989. http://www.theses.fr/1989NAN11118.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Kłosowska-Wardęga, Agnieszka. "Combination Therapies Targeting PDGF and VEGF Signaling Pathways in Solid Tumors." Doctoral thesis, Uppsala universitet, Ludwiginstitutet för cancerforskning, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-119827.

Full text

Abstract:

Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are independently involved in several cancer-associated mechanisms including autocrine stimulation of cancer cells, stimulation of tumor angiogenesis and regulation of interstitial fluid pressure (IFP). The scope of this thesis was to investigate the combinatory effect of anti-VEGF and anti-PDGF treatment on tumor angiogenesis and tumor IFP. Angiogenesis is a process of formation of blood vessels. Based on the tumors dependency on the blood vessels to supply them with oxygen and nutrients, several anti-angiogen

APA, Harvard, Vancouver, ISO, and other styles

27

Zhang, Yiqun. "Interpretation of transient temperature data from Permanent Down-hole Gauges (PDGs)." Thesis, Heriot-Watt University, 2015. http://hdl.handle.net/10399/2908.

Full text

Abstract:

With the installation of Permanent Down-hole Gauges (PDGs) during oil field development, a large volume of high resolution pressure, temperature and sometimes flow-rate data are available for real-time and continuous reservoir monitoring. In practice, interpretations of these data can optimize well performance, provide information about the reservoir and continuously calibrate the reservoir model. Although the wellbore is in a non-isothermal environment, heat transfer between the fluid in the wellbore and the formation is often ignored and temperature is usually assumed to be constant in the p

APA, Harvard, Vancouver, ISO, and other styles

28

Wang, Chun-Chao. "Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-08072008-162743/.

Full text

Abstract:

Intracellular signal transduction is traditionally characterized in terms of pathways, comprised of serial activation processes. Although it is appreciated that canonical signaling pathways are simply dominant routes of regulation embedded in larger interaction networks, relatively little has been done to quantify pathway crosstalk in such networks. Through quantitative measurements that systematically canvas an array of stimulation and molecular perturbation conditions, together with computational modeling and analysis, we have elucidated crosstalk mechanisms in the platelet-derived growth fa

APA, Harvard, Vancouver, ISO, and other styles

29

Pinto, Rodrigo Pozza. "Expressão imunoistoquímica do p16 e do PDGFR-beta no adenocarcinoma gástrico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2005. http://hdl.handle.net/10183/11082.

Full text

Abstract:

O adenocarcinoma de estômago foi a principal causa de morte por neoplasia maligna no mundo durante grande parte do século XX e atualmente é superado somente pelas neoplasias epiteliais malignas de pulmão. Cerca de 750.000 novos casos são diagnosticados anualmente. Apresenta grande variação geográfica, sendo suas maiores incidências encontradas no Japão, América do Sul, Europa Oriental e Oriente Médio. É duas vezes mais freqüente em homens do que em mulheres; é pouco comum antes dos 40 anos e atinge sua maior incidência por volta da sétima década de vida. No Brasil as estimativas para o ano de

APA, Harvard, Vancouver, ISO, and other styles

30

Paré, Martin. "L’implication de SHP-1 en condition élevée de glucose inhibe la signalisation de l’insuline et du PDGF-BB dans les cellules musculaires lisses vasculaires hypoxiques." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9502.

Full text

Abstract:

Résumé : Bien que l’hypoxie soit un puissant inducteur de l’angiogenèse, l’activation des facteurs de croissance est perturbée en hyperglycémie au niveau du pied et du cœur. Cette perturbation entraîne la perte de prolifération et de migration chez les cellules endothéliales, musculaires lisses vasculaires et péricytes empêchant la formation de nouveaux vaisseaux qui mènera à l’amputation des membres inférieurs chez les patients diabétiques. Une étude a démontré qu’une augmentation de la protéine tyrosine phosphatase Src homology-2 domain-containing phosphatase-1 (SHP-1) en condition hyperglyc

APA, Harvard, Vancouver, ISO, and other styles

31

Vassilikioti, S. "Studies on antisense inhibition of PDGF #beta#-receptor expression in cultured cells." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319894.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Shibuya, Hideyuki. "TNFα, PDGF and TGFβ synergistically induce synovial lining hyperplasia via inducible PI3Kδ". Kyoto University, 2015. http://hdl.handle.net/2433/199195.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Karlsson, Susann. "T-Cell Protein Tyrosine Phosphatase, a Regulator of the PDGF Signaling Pathway." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107674.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Keilhack, Nikolas [Verfasser]. "PDGF-BB fördert die Redifferenzierung in vitro expandierter humaner Gelenkchondrozyten / Nikolas Keilhack." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/1010798057/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Aravapalli, Kiran. "The effect of triiodothyronine on the expression of PDGF-BB in fibroblasts." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12046.

Full text

Abstract:

Thesis (M.A.)--Boston University<br>The thyroid gland consists of two types of cells that develop from distinct tissues. The parafollicular C-cells are derived from neural crest tissue and produce calcitonin, while the follicular cells produce thyroid hormone and are derived from endodermal tissue; thyroid hormone is the focus of this study. In the follicular cells, iodide is eventually metabolized into T4 and T3, with T4 being the primary production. Deiodinase 2 processes T4 into T3 because T3 serves the greatest physiological function. Thyroid hormone is crucial in maintaining basal metabol

APA, Harvard, Vancouver, ISO, and other styles

36

Venalis, Paulius. "Antifibrozinių priemonių paieška preklinikiniuose sisteminės sklerozės modeliuose." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20101001_150707-46435.

Full text

Abstract:

Sisteminė sklerozė (SSc) – viena sunkiausių ir fatališkiausių autoimuninių sisteminių reumatinių ligų, o bazinių vaistų stygius, šiai ligai gydyti, itin didelis. Į onkologinę klinikinę praktiką įdiegtas tirozinkinazių inhibitorius – imatinibo mezilatas(IM). IM blokuoja TGF-β ir PDGF intraląstelinio signalo perdavimą ir taip sąlygoja fibrozės prevenciją SSc pelių modelyje. Mums buvo svarbu išsiaiškinti, ar imatinibas gali turėti įtakos ne tik prevencijai, bet ir susiformavusiai fibrozei. Be to TGF-β ir PDGF blokavimas angiogenezėje, galėtų riboti daug žadančio fibrozės inhibitoriaus IM naudojim

APA, Harvard, Vancouver, ISO, and other styles

37

Venalis, Paulius. "The performance of antifibrotic agents in preclinical models of systemic sclerosis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20101001_150819-57019.

Full text

Abstract:

Systemic sclerosis (SSc) – is one of the most complicated and fatal systemic diseases, and the lack of effective therapy is very evident. The tyrosine kinase inhibitor imatinib mesylate (IM) was shown to inhibit TGF-β and PDGF signaling pathways and prevent the development of dermal fibrosis upon challenge with bleomycin in murine model of SSc. The aim of therapy is not only to stop disease progression, but even induce regression of preexisting fibrosis. On other hand, blocking TGF-β and PDGF signaling in angiogenesis might worsen the vascular manifestations of SSc. We found important to evalu

APA, Harvard, Vancouver, ISO, and other styles

38

Khouangvichit, Damdouane. "Socio-Economic Transformation and Gender Relations in Lao PDR." Doctoral thesis, Umeå universitet, Kulturgeografiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33937.

Full text

Abstract:

The aim of this study is to examine socio-economic transformation and gender relations in Lao PDR after the adoption of economic liberalization by the Lao government in the late 1980s. Against a background of general socio-economic transformation in Laos the main focus of the study is on the local level, with emphasis on how people in their everyday lives have engaged with and handled the changes. The application of economic liberalization shaped new conditions for people in local communities, and various livelihoods strategies were adopted under the new circumstances. The study examines gende

APA, Harvard, Vancouver, ISO, and other styles

39

Chounlamany, Kongsy, and Bounchanh Khounphilaphanh. "New methods of teaching? : refroming education in Lao PDR." Doctoral thesis, Umeå universitet, Pedagogiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40938.

Full text

Abstract:

This thesis is about the recent education reform in Laos as a global and a local process. When the economy was deteriorating in Lao People’s Democratic Republic (PDR), the so called New Economic Mechanism (NEM) was introduced and the country opened up for global donors and markets. This also had an effect on the education system. To get hold of financial support there were demands on Lao PDR to replace the previous strong centralised governing of education with more decentralised strategies. There were further demands to replace teacher-led lessons and rote learning with more student-centred c

APA, Harvard, Vancouver, ISO, and other styles

40

Phommavong, Saithong. "International tourism development and poverty reduction in Lao PDR." Doctoral thesis, Umeå universitet, Kulturgeografiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50070.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Santos, Marco Aurélio dos, and 9292212626. "Localização em ambientes internos utilizando PDR e Wi-Fi." Universidade Federal do Amazonas, 2018. https://tede.ufam.edu.br/handle/tede/6517.

Full text

Abstract:

Submitted by marco aurélio santos (marrco.santos@gmail.com) on 2018-07-30T01:42:52Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) msc_dissertacao_marcoSantos.pdf: 6142716 bytes, checksum: 17219663e0f7676d5c438178de493d89 (MD5)<br>Approved for entry into archive by Secretaria PPGI (secretariappgi@icomp.ufam.edu.br) on 2018-07-30T18:34:28Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) msc_dissertacao_marcoSantos.pdf: 6142716 bytes, checksum: 17219663e0f7676d5c438178de493d89 (MD5)<br>Approved fo

APA, Harvard, Vancouver, ISO, and other styles

42

Patcharanarumol, Walaiporn. "Health care financing for the poor in Lao PDR." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2008. http://researchonline.lshtm.ac.uk/4646530/.

Full text

Abstract:

As in many other developing countries, an official policy of user fees was adopted for the Lao health system in the 1990s. In principle, the poor were to be exempted from paying user fees at public health providers. This study aimed to contribute to policy on financial protection of the poor by (1) improving understanding of health care utilization and strategies adopted by households to deal with costs of Illness; (2) examining attitudes of policy makers and actual practice of public health care providers on fee exemptions of the poor; and (3) proposing better ways of protecting the poor. Bot

APA, Harvard, Vancouver, ISO, and other styles

43

AGARBATI, SILVIA. "Generation of human PDGFRα-transgenic mouse: a novel experimental model of skin fibrosis". Doctoral thesis, Università Politecnica delle Marche, 2020. http://hdl.handle.net/11566/274545.

Full text

Abstract:

ABSTRACT (Ita) Introduzione: Il recettore del PDGFα (fattore di crescita derivato dalle piastrine) è un target della risposta autoimmune nella sclerosi sistemica (SSc). Sia le IgG totali purificate da siero (SSc-IgG) che gli anticorpi anti-PDGFRα clonati da cellule B della memoria di pazienti sclerodermici (SSc-Mabs) [Moroncini G. et al., A&R 2015] hanno mostrato la capacità di incrementare la trascrizione del gene del collagene in fibroblasti ottenuti dalla cute di donatori sani e di indurre fibrosi ex vivo, su cute trapiantata in topi SCID [Luchetti M. et al., A&R 2016]. Al fine d

APA, Harvard, Vancouver, ISO, and other styles

44

Vora, Parvez Firoz. "Molecular regulation of myelination by Oligodendrocyte Progenitor cells." Experimental Neurology (Elsevier), 2010. http://hdl.handle.net/1993/8463.

Full text

Abstract:

Oligodendrocytes (OL) are the myelinating cells of the central nervous system (CNS). A series of complex cell signaling events in the CNS ensures successful myelination. Various molecular cues including growth factors, transcription factors and cytokines regulate myelination by inducing OL migration, proliferation and differentiation. Plateletderived growth factor A (PDGF-A) and fibroblast growth factor 2 (FGF2) are two of the most well characterized regulators of OP migration. The current study hypothesizes that PDGF-A and FGF2 regulate the migration of OP through transient activation of the

APA, Harvard, Vancouver, ISO, and other styles

45

Zheng, Wei. "The LAR protein tyrosine phosphatase enables PDGF β-receptor activation and signal transduction". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4364/.

Full text

Abstract:

Many cellular activities including cell survival, proliferation, migration and differentiation are controlled by growth factors and their corresponding tyrosine kinases receptor (RTKs). Growth factor receptor activation is strictly regulated by protein tyrosine phosphatases (PTPs). Here I investigated whether the receptor protein tyrosine phosphatase (RPTP) LAR, which is known to modify the activity of several RTKs, also regulates platelet derived growth factor (PDGF) receptor activity and signalling. Mouse embryonic fibroblasts (MEFs) expressing mutant LAR lacking its phosphatase domains (LAR

APA, Harvard, Vancouver, ISO, and other styles

46

Phouxay, Kabmanivanh. "Patterns of migration and socio-economic change in Lao PDR." Doctoral thesis, Umeå universitet, Kulturgeografiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37321.

Full text

Abstract:

The aim of the thesis is to investigate patterns and consequences of internal and international migration in Laos during the period 1985-2005 on both a macro-and a micro-level. The thesis focuses on the influences of socio-economic change and government policies on inter-regional and rural-urban migration as well as on crossborder migration from Laos to Thailand. The study also examines the effects of migration and industrial factory work on gender relations during economic transition and consequences of undocumented migration to Thailand. The background consists of a discussion on socio-econo

APA, Harvard, Vancouver, ISO, and other styles

47

Bounyasone, Keophouthong, and Ngouay Keosada. "Cultivating educational research in Lao PDR : For a better future?" Doctoral thesis, Umeå universitet, Pedagogiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42905.

Full text

Abstract:

This thesis looks at the introduction of educational action research as part of the national education reforms in Lao PDR. National policies on education emphasise concepts such as ‘education for all’ and ‘student-centred education’ taken from the globalised education reform agenda. Action research became a tool to implement the new pedagogy of student-centred education that was labelled ‘the five-pointed star’. The thesis contributes to the field of global policy studies. It combines global and contextual aspects in order to analyse how action research travelled from policy to practice. This

APA, Harvard, Vancouver, ISO, and other styles

48

Burniston, Stephanie. "Mixed methods analysis of pig associated zoonoses in Lao PDR." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28811.

Full text

Abstract:

Southeast Asia carries a large burden of endemic zoonotic diseases, in livestock and humans, especially in countries where livestock production is increasing among rural households for income generation and poverty reduction. This thesis explores the risk factors for transmission of pig-associated zoonoses – particularly Q fever, brucellosis, hepatitis E, and Japanese encephalitis – in northern Lao PDR, with a view to development of recommendations for “catch-all” control measures to impact on multiple diseases, improving biosecurity and preventing disease transmission to the human population.

APA, Harvard, Vancouver, ISO, and other styles

49

Chaabeni, Sihem. "Les PDG français et leur rôle dans le gouvernement d'entreprise." Toulouse 1, 2003. http://www.theses.fr/2003TOU10063.

Full text

Abstract:

En France, les débats actuels restent centrés sur la réalité du gouvernement d'entreprise (GE) ranimés par la passivité des organes de contrepouvoir. D'autre part, le capitalisme à la Française fortement imprégné de la personnalité publique ne peut qu'affecter l'origine des dirigeants sociaux. Le 1er chapitre est consacré au capitalisme à la française et à l'avènement de la révolution managériale en France. Le 2ème concerne une étude biographique des PDG français via leur origine sociale et leurs cursus. On pourrait ainsi juger de leur mode de recrutement et son adéquation avec le principe de

APA, Harvard, Vancouver, ISO, and other styles

50

Daosavanh, SANAMXAY. "Systematic Study of Flying Squirrels (Mammalia, Sciuridae) in Lao PDR." Kyoto University, 2020. http://hdl.handle.net/2433/252971.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!