Academic literature on the topic 'Patrolling monocyte'

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Journal articles on the topic "Patrolling monocyte"

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Liu, Yunfeng, Fangmiao Jing, Woelsung Yi, et al. "HO-1hi patrolling monocytes protect against vaso-occlusion in sickle cell disease." Blood 131, no. 14 (2018): 1600–1610. http://dx.doi.org/10.1182/blood-2017-12-819870.

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Key Points SCD patients with a recent VOC episode have lower frequencies and numbers of HO-1hi patrolling monocytes. Heme-driven SCD vaso-occlusion is exacerbated in mice lacking patrolling monocytes and reversed following patrolling monocyte transfer.
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Finsterbusch, Michaela, Pam Hall, Anqi Li, et al. "Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus." Proceedings of the National Academy of Sciences 113, no. 35 (2016): E5172—E5181. http://dx.doi.org/10.1073/pnas.1606253113.

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Nonclassical monocytes undergo intravascular patrolling in blood vessels, positioning them ideally to coordinate responses to inflammatory stimuli. Under some circumstances, the actions of monocytes have been shown to involve promotion of neutrophil recruitment. However, the mechanisms whereby patrolling monocytes control the actions of neutrophils in the circulation are unclear. Here, we examined the contributions of monocytes to antibody- and neutrophil-dependent inflammation in a model of in situ immune complex-mediated glomerulonephritis. Multiphoton and spinning disk confocal intravital m
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Liu, Yunfeng, Fangmiao Jing, Woelsung Yi, et al. "Protective Role of HO-1 Expressing CD16+ Patrolling Monocytes Against Hemolysis-Induced Endothelial Damage and Vaso-Occlusive Crisis in Sickle Cell Disease." Blood 130, Suppl_1 (2017): 767. http://dx.doi.org/10.1182/blood.v130.suppl_1.767.767.

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Abstract Causing leukocyte activation and upregulation of adhesion molecules on endothelial cells. CD16+ monocytes, also known as endothelial patrolling monocytes, normally scavenge the damaged cells and debris from the vasculature. As compared to other monocyte subsets or immune cell types, the CD16+monocyte subset expresses higher levels of the anti-inflammatory heme oxygenase 1 (HO-1), a heme degrading enzyme. Given the role of CD16+ monocytes as scavengers of debris on endothelial cells, we tested the hypothesis that this subset may protect SCD vasculature from the ongoing hemolytic insult
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Marcovecchio, Paola M., Graham D. Thomas, Zbigniew Mikulski, et al. "Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis." Arteriosclerosis, Thrombosis, and Vascular Biology 37, no. 11 (2017): 2043–52. http://dx.doi.org/10.1161/atvbaha.117.309123.

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Objective— Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of monocytes responds to viruses, tumor cells, and other pathogens to aid in protection of the host. In this study, we wished to determine how early atherogenesis impacts NCM patrolling in the vasculature. Approach and Results— To study the role of NCM in early atherogenesis, we quantified the patrolling behaviors of NCM in ApoE −/− (apolipoprotein E) and C57BL/6J mice fed a Western diet. Using intravital imaging, we found that NCM from Western diet–fed
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Thomas, Graham, Robert Tacke, Catherine C. Hedrick, and Richard N. Hanna. "Nonclassical Patrolling Monocyte Function in the Vasculature." Arteriosclerosis, Thrombosis, and Vascular Biology 35, no. 6 (2015): 1306–16. http://dx.doi.org/10.1161/atvbaha.114.304650.

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Contreras, Cristina F., Sabina Kaczanowska, and Rosandra N. Kaplan. "Function of circulating myeloid cells in healthy donors and patients with metastatic solid tumors." Journal of Immunology 206, no. 1_Supplement (2021): 101.03. http://dx.doi.org/10.4049/jimmunol.206.supp.101.03.

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Abstract Monocytes are a heterogeneous group of mononuclear innate immune cells that have diverse inflammatory responses. In the context of cancer, monocytes and monocyte-derived cells have been evaluated for their pro- and anti-tumoral effects in the tumor microenvironment. These functions range from induction of tumor cell death to suppression of T cells, promotion of angiogenesis and remodeling of the extracellular matrix. Outside of the primary tumor, monocytes in circulation maintain their dichotomous role in cancer immunosurveillance. Specifically, patrolling non-classical CD14−CD16+ mon
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Contreras, Cristina F., Sabina Kaczanowska, and Rosandra N. Kaplan. "Transcriptomic and epigenetic profiling of tumor-associated monocyte function." Journal of Immunology 208, no. 1_Supplement (2022): 179.07. http://dx.doi.org/10.4049/jimmunol.208.supp.179.07.

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Abstract Monocytes are innate immune cells recognized for their ability to play both tumor permissive and surveillant roles in cancer. Circulating classical monocytes (CD14+CD16−) can home to the tumor and suppress other immune cells through various mechanisms, including the production of arginase and the release of reactive oxygen species (ROS). Conversely, patrolling nonclassical monocytes (CD14−CD16+) have been shown to employ processes such as phagocytosis and presentation of tumor antigens to prevent metastasis. This heterogeneous monocyte function is influenced by tumor-derived factors t
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O’Connor, Kevin W., Tiantian Liu, Sunkyung Kim, Theresa Murphy, and Kenneth M. Murphy. "Notch2, Bcl6, and IRF2 govern differentiation and survival of murine nonclassical monocytes." Journal of Immunology 208, no. 1_Supplement (2022): 163.20. http://dx.doi.org/10.4049/jimmunol.208.supp.163.20.

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Abstract Nonclassical (patrolling) monocytes are a population of monocytes which monitor the vasculature and participate in tissue repair. Though nonclassical monocytes are thought to be developmentally derived from classical monocytes, the mechanisms that control the differentiation of classical monocytes into nonclassical monocytes are still not completely understood. Signaling through the Notch2 receptor appears to trigger development of nonclassical monocytes. Also, the transcription factors C/EBPβ and Nur77 (Nr4a1) are required for nonclassical monocyte development in vivo. We have now id
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França, Carolina N., Maria C. O. Izar, Marinella N. S. Hortêncio, et al. "Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease." Clinical Science 131, no. 12 (2017): 1215–24. http://dx.doi.org/10.1042/cs20170009.

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Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14++CD16−CCR2++ cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14++CD16+CCR2+) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β). Non
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Regal-McDonald, Kellie, Brittney Xu, Jarrod W. Barnes, and Rakesh P. Patel. "High-mannose intercellular adhesion molecule-1 enhances CD16+ monocyte adhesion to the endothelium." American Journal of Physiology-Heart and Circulatory Physiology 317, no. 5 (2019): H1028—H1038. http://dx.doi.org/10.1152/ajpheart.00306.2019.

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Human monocytes have been classified into three distinct groups, classical (anti-inflammatory; CD14+/CD16−), nonclassical (patrolling; CD14+/CD16++), and intermediate (proinflammatory; CD14++/CD16+). Adhesion of nonclassical/intermediate monocytes with the endothelium is important for innate immunity, and also vascular inflammatory disease. However, there is an incomplete understanding of the mechanisms that regulate CD16+ versus CD16− monocyte adhesion to the inflamed endothelium. Here, we tested the hypothesis that a high-mannose (HM) N-glycoform of intercellular adhesion molecule-1 (ICAM-1)
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Dissertations / Theses on the topic "Patrolling monocyte"

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Bohm, Mathieu. "Development and functions of patrolling monocytes and kidney resident macrophages." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/development-and-functions-of-patrolling-monocytes-and-kidney-resident-macrophages(a5f40c53-d464-453a-8c8d-c0ac8e268d3f).html.

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Mononuclear phagocytes are crucial arms of the innate immune system, performing various fonctions, from clearance of pathogenic microorganisms, to maintenance of tissue homeostasis. Two cell types have been studied; first, monocytes, bone marrow-derived cells, of which two main subsets have been described. Ly6C+ monocytes are short-lived circulating cells that have the ability to quickly migrate into tissues, and produce a range of molecules, or differentiate into inflammatory cells. Ly6Clow monocytes are a patrolling cell type, which crawls on the luminal side of vessels where they perform a
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