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Dissertations / Theses on the topic 'Patient Pathways'

Author: Grafiati

Published: 29 March 2025

Last updated: 25 July 2025

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1

Debbage, Samantha D. "Do integrated care pathways improve patient outcomes?" Thesis, University of Sheffield, 2009. http://etheses.whiterose.ac.uk/14949/.

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The purpose of the study was to determine if the use of an Integrated Care Pathway (ICP) was associated with more positive outcomes than traditional methods of care. The effectiveness of the ICP had not previously been tested (in relation to traditional methods of care) to determine if it made any difference, at a patient, staff or system (healthcare organisation) level. In February 2001 (as part of the NHS modernisation agenda) the gynaecology services within one UK city were re-organised and two separate units were merged into one new larger unit. Prior to the reorganisation, the two units o

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2

Zulkepli, Jafri. "A theoretical framework for hybrid simulation in modelling complex patient pathways." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6448.

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Providing care services across several departments and care givers creates the complexity of the patient pathways, as it deals with different departments, policies, professionals, regulations and many more. One example of complex patient pathways (CPP) is one that exists in integrated care, which most literature relates to health and social care integration. The world population and demand for care services have increased. Therefore, necessary actions need to be taken in order to improve the services given to patients in maintaining their quality of life. As the complexity arises due to differ

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3

Gaddari, Abdelhamid. "Analysis and Prediction of Patient Pathways in the Context of Supplemental Health Insurance." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10299.

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Ce travail de thèse s'inscrit dans la catégorie de la recherche en informatique de santé, en particulier l'analyse et la prédiction des parcours patients, qui sont les séquences des actes médicaux consommés par les patients au fil du temps. Notre objectif est de proposer une approche innovante pour l'exploitation des données de parcours de soins afin de réaliser non seulement une classification binaire, mais aussi multi-label. Nous concevons également une nouvelle approche de vectorisation et représentation sémantique exclusivement pour le domaine médical français, qui permettra d'exploiter un

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4

NEVES, MARIANA GUERRA BARSTAD CASTRO. "THE DOCTOR-PATIENT RELATIONSHIP FROM THE ATTACHMENT THEORY S PERSPECTIVE: THINKING PATHWAYS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2018. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34746@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO<br>PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTITUIÇÕES COMUNITÁRIAS DE ENSINO PARTICULARES<br>A relação médico-paciente consiste numa díade que é hierarquicamente assimétrica. Uma parte cuida e a outra recebe cuidado, análogo ao que ocorre nas relações de apego. O médico teria o papel de figura de apego, possibilitando ativar o seu sistema de cuidado. O objetivo deste estudo é analisar como o sistema de cuidado está inseri

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Smeds, Magdalena. "Managing care pathways for patients with complex care needs." Licentiate thesis, Linköpings universitet, Logistik- och kvalitetsutveckling, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-156836.

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One of the central challenges for the healthcare system today is how to manage care for patients with complex needs. This patient group is not well-defined but covers patients with serious diseases and comorbidities, or with a limited ability to perform basic daily functions due to physical, mental or psychosocial challenges. This group has a high service and resource utilisation resulting in high costs for the healthcare system and, typically, poor health outcomes. To improve care for these patients, it is necessary to implement strategies to manage the differentiated care needs, the addition

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6

Bhattacharya, Abhik. "Development of a framework to identify patient pathways through a segment of the health care cycle." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002866.

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7

Pelletier, Lori Rebecca. "Information-Enabled Decision-Making in Health Care: EHR-Enabled Standardization, Physician Profiling and Medical Home." Digital WPI, 2010. https://digitalcommons.wpi.edu/etd-dissertations/166.

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Health care today harms too frequently and routinely fails to deliver its potential benefits. Significant evidence suggests that high quality primary care can positively affect health outcomes. I explored three related topics mentioned frequently in current United States health reform €“ Electronic Health Records (EHR), physician profiling and Medical Home. An investment in these areas is expected to significantly improve quality of care and efficiency; however, there is only a patchwork of evidence supporting such claims. To achieve EHR promises, my research employed a standardization len

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8

Namaki, Araghi Sina. "A methodology for business process discovery and diagnosis based on indoor location data : Application to patient pathways improvement." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2019. http://www.theses.fr/2019EMAC0014.

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Dans chaque organisation, les processus métier sont aujourd’hui incontournables. Cette thèse vise à développer une méthode pour les améliorer. Dans le domaine de la santé, les organisations hospitalières déploient beaucoup d’efforts pour mettre leurs processus sous contrôle, notamment à cause de la très faible marge d’erreur admise. Les parcours des patients au sein des structures de santé constituent l’application qui a été choisie pour démontrer les apports de cette méthode. Elle a pour originalité d’exploiter les données de géolocalisation des patients à l’intérieur de ces structures. Bapti

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9

Lea, Troy William. "Spiritual Pathways to Healing and Recovery: An Intensive Single-N Study of a Patient with an Eating Disorder." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6022.

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This study presents an in-depth case study of eight sessions of spiritually integrated psychotherapy with a 20-year-old woman recovering from an Eating Disorder. The inclusion and utility of session-to-session outcome data as well as systematic follow up data in conjunction with in-depth qualitative interviews are shown. The therapist and client's perspectives are highlighted over the course of treatment. Three clinical areas of focus (renewing identity, reducing self-contempt, and fostering hope) are extracted from the qualitative interviews and the therapeutic process of weaving them togethe

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10

Hajdarevic, Senada. "Patient and health care delays in malignant melanoma." Doctoral thesis, Umeå universitet, Dermatologi och venereologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54392.

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Background: Unlike other cancers, malignant melanoma (MM) is generally visible and can be easily and effectively cured if treated in time. Optimal cure of MM requires early detection, diagnosis, and treatment, which improves prognosis. However, patients as well as the health care organization and its professionals contribute to delayed treatment in various ways. Aims and objectives: The general aim of this PhD thesis was to explore reasons for delay in care seeking, diagnosis, and treatment of malignant melanoma. The specific objectives to be addressed were To explore patients’ decision making

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Bailey, Janelle Lee. "Language Pathways Defined in a Patient with Left Temporal Lobe DamageSecondary to Traumatic Brain Injury: A QEEG & MRI Study." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4363.

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Though the current understanding of language processing is incomplete, it has been established that the left hemisphere is dominant for language in the majority of the population. Damage to language centers of the brain and to white matter tracts connecting these language centers results in a language deficit known as aphasia. Neuroplasticity in the brain can often compensate for these language deficits by strengthening neuronal connections between the right and left hemisphere, or by enhancing the neuronal connectivity of undamaged areas in the left hemisphere. Thus the brain can compensate f

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12

Nakajima, Aya. "Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix." Kyoto University, 2015. http://hdl.handle.net/2433/199178.

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13

Duarte, Anette. "Standardvårdplaner – till vilken nytta?" Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-5836.

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<p>Standardvårdplaner är vanligt förekommande inom hälso- och sjukvård och är under ständig utveckling. Standardvårdplaner är i olika grad evidensbaserade och framtagna med skiftande kvalitet. Standardvårdplaner används som ett hjälpmedel för effektivisering och kvalitetshöjning av vården för en specifik patientgrupp och är en på förhand formulerad vårdplan. Behov av ytterligare forskning efterfrågas om standardvårdplaner faktiskt minskar mängden dubbeldokumentation, leder till ökad tidsvinst och ökad vårdkvalitet. Syftet med föreliggande litteraturstudie var att göra en beskrivning av de effe

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14

Steen, Scott. "Understanding the processes involved in implementing an improving access to psychological therapies service : an exploratory study that investigates practitioner and client experience regarding its effect on patient pathways, service design and overall outcomes." Thesis, University of Chester, 2015. http://hdl.handle.net/10034/620323.

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The English Improving Access to Psychological Therapies (IAPT) programme is a government-funded initiative that aims to provide timely and equitable access to evidence-based psychotherapeutic interventions, within a primary care setting. Despite the many achievements of the programme, there are several issues regarding research to clinical gaps, as well as a high rate of variation between sites concerning outcomes and attrition. This thesis explores the implementation process of the IAPT delivery model to understand which factors are influential in the successful uptake and integration of evid

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15

Dehghan, Azad. "Mining patient journeys from healthcare narratives." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/mining-patient-journeys-from-healthcare-narratives(69ebfa6d-764a-4dfe-bbf8-6aab1905a6f3).html.

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The aim of the thesis is to investigate the feasibility of using text mining methods to reconstruct patient journeys from unstructured clinical narratives. A novel method to extract and represent patient journeys is proposed and evaluated in this thesis. A composition of methods were designed, developed and evaluated to this end; which included health-related concept extraction, temporal information extraction, and concept clustering and automated work-flow generation. A suite of methods to extract clinical information from healthcare narratives were proposed and evaluated in order to enable c

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16

Jones, Karen. "The remodelling of patient care pathway for e-health." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/3975.

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The interdependencies within the health care system are seldom taken into account prior to implementation of e-health projects, and there tends to be little change management as part of the plan. Our proposal offers a systems analysis model that gives e-health a framework to consider and manage the introduction, changes and outcomes. This research describes the use of a modified Patient Care Pathway as a method to design and implement e-health projects, presenting as a case study the pre-implementation phase of a teleradiology project in rural Thailand. The proposal is that a modified version

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17

Barker, Tina M. "The Use of Clinical Pathways in Patients with Thoracic Injuries." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1586891718248184.

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18

Alassiri, Mohammed. "Characterising the PEPITEM pathway in patients with atherosclerosis." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7065/.

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Atherosclerosis is an asymptomatic disease which is regarded as one of the most fatal diseases. However, the mechanism of the immune response is not well understood. There is accumulated evidence supporting the idea that inflammatory response initiates the disease. A new novel peptide has been discovered in our lab which down-regulates T cell recruitment during inflammation called PEPITEM (Peptide Inhibitor of Trans Endothelial Migration). We are interested in testing the action of PEPITEM on PBL isolated from atherosclerosis patients. We first demonstrated that PEPITEM did not affect the leve

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19

Lewis, William. "Changes in Language Pathways in Tuberous Sclerosis Complex Patients with Autism." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/45.

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Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous disease caused by loss of the TSC1 (encoding hamartin) or TSC2 (encoding tuberin) genes. Neurologic symptoms are common and varied in TSC and include epilepsy and behavioral conditions like autism spectrum disorders (ASD). Between 17 and 61% of children with TSC exhibit symptoms of ASD. The purpose of this study was to investigate a potential correlate of poor neurological outcome in TSC by assessing the integrity of brain language pathways and the relationship to ASD. 42 patients with TSC and 42 age-matched control sub

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20

Brown, Helen Gaenor. "Transient Ischaemic Attack (TIA) Management study." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/366821.

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BACKGROUND: There is increasing evidence of a high early risk of stroke following TIA. Patients presenting after a TIA offer a unique opportunity for the urgent initiation of proven secondary preventive measures known to reduce the risk of a subsequent stroke. Despite this many TIA patients remain under-investigated and under-treated. OBJECTIVE: The aim of this study was to assess whether a structured treatment pathway would improve patient management and outcomes. The clinical pathway categorizes patients with TIA into high or low-risk for stroke according to the ABCD2 prognostic scoring syst

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21

Henriksson, Gert. "Clinical, immunological and olfactory aspects of sinusitis and nasal polyposis : with special reference to patients with cystic fibrosis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-151-2/.

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22

Phethi, T. S. "Help-seeking pathways followed by patients with chronic diseases:the case of ga-Dikgale." Thesis, University of Limpopo, 2014. http://hdl.handle.net/10386/1229.

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Thesis (M.A. (Clinical Psychology)) --University of Limpopo, 2014<br>The aim of the study was to investigate help-seeking pathways that are followed by patients with chronic disease in one rural community in Limpopo Province. Specifically, the objectives of the study were: a). to investigate help-seeking pathways that were followed by patients with chronic diseases before and after they were diagnosed with their condition; b). to explore the treatment modalities that were used by the patients before they started receiving hospital treatment for their chronic conditions; and, c). to determine w

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Bouyssou, Isabelle. "Deciphering Plasmodium vivax invasion pathway(s) in Duffy-negative patients." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS180.pdf.

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Le paludisme à Plasmodium vivax est une maladie infectieuse causée par le parasite protozoaire Plasmodium vivax et transmise par les moustiques femelles Anopheles. Cette maladie est prévalente en Amérique, Asie, Moyen-Orient, Pacifique, Afrique du Nord-Est et Afrique du Sud mais demeure rare en Afrique sub-saharienne. Historiquement, la maladie était considérée bégnine et peu dangereuse du fait de l'observation de faibles parasitémies chez les patients Duffy-positifs et de l'absence virtuelle d'infections chez les individus Duffy-négatifs. Des études ont montré que les individus d'origine afri

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DiRocco, Dianne Boyer. "The effect of critical pathways on length of stay for cerebrovascular accident patients." FIU Digital Commons, 1995. http://digitalcommons.fiu.edu/etd/2823.

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The purpose of this study was to (a) determine the effect of a critical pathway on the length of hospital stay for patients diagnosed with cerebrovascular accident, and (b) identify the variances associated with delayed length of stay for patients admitted after the implementation of the critical pathway. The sample included 34 patients (Male = 14; Female = 20) diagnosed with either hemorrhagic cerebrovascular (n = 4) or non-hemorrhagic (n = 30) accidents. The mean age was 68 years. A t-test comparing the length of stay for patients admitted to the hospital before (Mean = 8.59, SD = 4.95) and

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Jury, Elizabeth Carole. "Dysregulated intracellular signalling pathways in T lymphocytes from patients with systemic lupus erythematosus." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411032.

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Leurs, Paul B. "Tissue factor pathway inhibitor in patients with diabetes mellitus an epiphenomenon? /." Maastricht : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=6971.

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27

Taylor, Clare Joanne. "The clinical pathway of patients with heart failure in primary care." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6557/.

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Background: Heart failure is a common clinical syndrome associated with major adverse symptoms and poor outlook for patients, and high costs for healthcare systems globally. This thesis examines four aspects of the clinical pathway of patients with heart failure in primary care. Methods: Routinely collected GP records are used to estimate the number of newly diagnosed heart failure cases by year. A qualitative interview study explores the patient experience of the diagnostic pathway. Survival analysis is used to determine prognosis of patients following a first diagnostic label. Finally, a scr

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Mateu, Jiménez Mercè 1990. "Mechanisms and pathways involved in lung tumor development in patients with chronic respiratory conditions." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664501.

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Chronic respiratory diseases, especially chronic obstructive pulmonary disease (COPD), and several molecular mechanisms may predispose to lung cancer (LC) development. Hypothesis: We hypothesized that different biological mechanisms such as oxidative stress, inflammatory events and epigenetic alterations may alter key cellular processes that are strongly involved in tumor initiation and progression in COPD patients. Objectives: In tumor and non-tumor lungs and in blood, to explore potential differences between LC patients with and without COPD, in several biological mechanisms that underlie lu

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Chiu, Chim-keung, and 趙漸強. "Pathways to care: help seeking pattern of thepeople with early psychosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B43895244.

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30

Huang, Norman Jason. "Graph-based Support Vector Machines for Patient Response Prediction Using Pathway and Gene Expression Data." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11072.

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Over the past decade, multiple function genomic datasets studying chromosomal aberrations and their downstream implications on gene expression have accumulated across a variety of cancer types. With the majority being paired copy number/gene expression profiles originating from the same patient groups, this time frame has also induced a wealth of integrative attempts in hope that the concurrent analysis between both genomic structures will result in optimized downstream results. Borrowing the concept, this dissertation presents a novel contribution to the development of statistical methodology

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Hodkinson, Peter William. "Developing a patient-centred care pathway for paediatric critical care in the Western Cape." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/17259.

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Includes bibliographical references<br>Background: Emergency care of critically ill or injured children requires prompt identification, high quality treatment and rapid referral. This study examines the critical care pathways in a health system to identify preventable care failures by evaluating the entire pathway to care, the quality of care at each step along the referral pathway, and the impact on patient outcomes. Methods: A year-long cohort study of critically ill and injured children was performed in Cape Town, South Africa, from first presentation until paediatric intensive care unit ad

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Yeung, Y. Y. Louisa, and 楊月瑩. "Cantonese dichotic digit test: a comparison between normative and cleft palate groups." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37990469.

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Bipath, Priyesh. "Tryptophan and the kynurenine pathway in chronic renal failure patients on dialysis." Diss., Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-10212008-135418.

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Sun, Tingting [Verfasser]. "Genetic versus epigenetic BRCA1 silencing pathways: clinical effects in primary ovarian cancer patients / Tingting Sun." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1189139227/34.

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Wang, Jing. "Genetic and functional analysis of pathways regulating sodium handling in patients with low renin hypertension." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611982.

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Yilma, Lemma. "Pathways to diagnosis and treatment : TB patients' experiences in London : a narrative enquiry and analysis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2011. http://researchonline.lshtm.ac.uk/1379947/.

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The purpose of this study was to understand TB patients' experiential accounts of access to TB diagnosis and treatment and more specifically about their experiences of medical help from health care professionals. METHOD: This narrative enquiry was undertaken in three boroughs of London, including two boroughs with the highest TB notification rates in the UK. The study involved pilot interviews with ten patients to develop the research question. In-depth narrative interviews with 32 additional patients were then undertaken. All participants were over eighteen years of age. The analysis of narra

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Almotiri, Naif. "Teleconsultation perspective for cardiovascular patients in Saudi Arabia." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/7343.

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This research of teleconsultation services aims to improve the quality of diagnosis and treatment for rural cardiovascular patients through utilizing distant medical expertise. Equitable access to expert healthcare as well as improved medical management for these patients can assist in modifying cardiovascular disease (CVD) risk and reduce morbidity and mortality in Saudi Arabia. The objectives were to design and develop a new care pathway for cardiovascular disease patients by utilizing teleconsultation technology, investigate factors and issues that might act as barriers to its adoption, and

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George, Caroline L. "Controlling Time Spent with Patients: A Pathway for Nurses to Feel Competent While Minimizing Burnout." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1626356561343293.

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Roth, Erik, and Johanna Holmbom. "Sjuksköterskors upplevelser av att vårda patienter i livets slutskede enligt Liverpool Care Pathway (LCP)." Thesis, Högskolan Dalarna, Omvårdnad, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:du-12576.

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Syfte: Att beskriva sjuksköterskors upplevelser av att vårda patienter i livets slutskede enligt en vårdplan utformad som en journal med riktlinjer för vård i livets slutskede, den så kallade Liverpool Care Pathway (LCP). Metod: Studien är utförd som en litteraturöversikt. Artiklarna söktes via databaserna CINAHL, PubMed, MedLine, SAGE Journals och Scopus. Tolv artiklar valdes ut för kvalitétsgranskning enligt en förutbestämd granskningsmall. Elva artiklar godkändes och utgjorde grunden för resultatet. Resultat: En tydlig effekt av införandet av LCP var att sjuksköterskorna upplevde ett ökat s

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ZEMA, MADDALENA. "Design of clinical pathway management system for preventing adverse event." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2684403.

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A clinical pathway (CP) - also known as care map or integrated care pathway - is a collection of evidence-based recommendation on the sequence and timing of care interventions for a diagnosis. CP analysis has experienced increased attention over the years because it is useful both for the health-care management in general and for the administration, computerization and scheduling the best practice for individual patients. Indeed, significant improvement in the quality of almost all available clinical processes was observed after the CP development and implementation. In addition, reductions

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Acum, Michelle. "End of pathway cleft surgery : exploring the patient-reported outcomes and young people's decision making experiences." Thesis, University of East Anglia, 2018. https://ueaeprints.uea.ac.uk/68908/.

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Objective: Literature exploring how young people (YP) experience cleft surgery at the end of the treatment pathway is limited, both in terms of their reported outcomes and their experience of deciding whether to undergo surgery. This thesis aimed to add to the cleft field by reviewing the patient-reported outcomes (PROs) of end of pathway cleft surgery and exploring YP’s experiences of deciding whether to undergo orthognathic surgery (OS; an end of pathway cleft surgery). Design: A systematic literature search identified studies measuring the PROs of undergoing end of pathway cleft surgery. To

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Yan, Edwin B., Tony Frugier, Chai K. Lim, et al. "Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans." BioMed Central, 2015. http://hdl.handle.net/10150/610324.

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ABSTRACT: During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydroxykynurenine (3HK). Despite the importance of excitotoxicity in the development of secondary brain damage, investigations on the KP in TBI are scarce. In this study, we comprehensively characterised changes in KP activation by measuring numerous metabolites in cerebrospinal fluid (CSF) from TBI patients and assessing the expression of key KP enzymes in brain tissue from TBI victims. Acute

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Pullen, Emma. "Sport and exercise medicine in NHS England : the pathways of sport-related injury patients and social costs." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/24731.

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This thesis explores the general public s experiences of sport related injury (SRI) as they utilise Sport and Exercise Medicine services in NHS England. It focuses specifically on: the treatment pathways to, and utilisation of, one Sport and Exercise Medicine (SEM) clinic in NHS England; the social and economic costs incurred as a consequence of SRI; and the extent healthcare utilisation and costs coalesce to structure SRI experience. The study employs a qualitative methodology based on a two phase research design that retrospectively maps the pathways of patients (n=19) up until their treatme

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Bluschke, Annet, der Hagen Maja von, Katharina Papenhagen, Veit Roessner, and Christian Beste. "Conflict processing in juvenile patients with neurofibromatosis type 1 (NF1) and healthy controls – Two pathways to success." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-227045.

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Neurofibromatosis Type 1 (NF1) is a monogenetic autosomal-dominant disorder with a broad spectrum of clinical symptoms and is commonly associated with cognitive deficits. Patients with NF1 frequently exhibit cognitive impairments like attention problems, working memory deficits and dysfunctional inhibitory control. The latter is also relevant for the resolution of cognitive conflicts. However, it is unclear how conflict monitoring processes are modulated in NF1. To examine this question in more detail, we used a system neurophysiological approach combining high-density ERP recordings with sour

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Venchiarutti, Rebecca. "Pathways to diagnosis and treatment of head and neck cancer: outcomes and experiences of patients in NSW." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25061.

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Delayed diagnosis and treatment of cancer can lead to poor outcomes. These relationships have not been well explored in Australia for head and neck cancer (HNC) patients. This thesis examines pathways to diagnosis and treatment of patients with HNC in New South Wales (NSW) with focus on the impact of remoteness of residence. Three primary studies were conducted. A retrospective cohort study reports on 224 patients treated for oropharyngeal or oral cavity cancer at two centres from 2008-2013. Regional patients had longer times to treatment and post-operative radiotherapy (PORT) compared to metr

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SIRONI, ALESSANDRA. "UNVEILING MOLECULAR PATHWAYS DISRUPTED IN SMS AND SMS-LIKE PATIENTS BY MEANS OF GENOMIC AND FUNCTIONAL APPROACHES." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/700745.

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Smith Magenis Syndrome (SMS, OMIM#182290) is a complex genomic disorder with incidence of 1:15000-25000, clinically characterized by neurological abnormalities with variable intellectual disability (ID), craniofacial dysmorphisms, behavioral and sleep disturbances, and speech and motor delay. SMS is caused by haploinsufficiency of RAI1 (Retinoic Acid-Induced 1) gene to either large 17p11.2 deletion (90%) or point mutations/intragenic microdeletions (10%). RAI1 encodes a transcription factor, working as chromatin reader in a regulatory complex, that positively regulates the expression of many n

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Abd, kader Khaled. "Disruption of the JakSTAT cytokine signaling pathway in T cells from HIV-infected patients." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27566.

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HIV infection leads to a profound T cell dysfunction well before the clinical onset of AIDS. This study investigated whether alterations in the Janus kinase (Jak)/signal transducer and activator of transcription (STAT) pathway in CD4+ and CD8+ T cells from HIV-infected patients induced by the growth promoting cytokines IL-2, IL-4, IL-7, IL-10, and IL-15 may be involved. IL-2 and IL-15 induced STAT5 phosphorylation (P-STAT5) in CD4+ T cells but there was a clear separation of cells into P-STAT5- and P-STAT5+ populations to similar proportions in HIV- and HIV+ patients. In response to IL-7, the

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Mendoza, Alonzo Jennifer Lorena. "Predicting the Clinical Outcome in Patients with Traumatic Brain Injury using Clinical Pathway Scores." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4544.

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The Polytrauma/TBI Rehabilitation Center (PRC) of the Veterans Affairs Hospital (VAH) treats patients with Traumatic Brain Injury (TBI). These patients have major motor and cognitive disabilities. Most of the patients stay in the hospital for many months without major improvements. This suggests that patients, family and the VAH could benefit if healthcare provider had a way to better assess or "predict" patients' progression. The individual progress of patients over time is assessed using a pre-defined multi-component performance measure Functional Independence Measures (FIM) at admission and

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Pelligra, Amanda. "Surgical Pathway Implementation for Pediatric Patients with Multiple Chronic Conditions Undergoing Complex Hip Surgery." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1617296741840046.

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Brunini, Tatiana Marlowe Cunha. "L-arginine-nitric oxide pathway in blood cells from chronic renal and heart failure patients." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326115.

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