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Dissertations / Theses on the topic 'Pathological'

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Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2024

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1

Hahs, Adam D. "The effects of augmentals on pathological and non-pathological gamblers' slot-machine play /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1594477131&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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2

Cheng, Wai-kwan Scarlette. "From pathological gambling to help-seeking : cases of female pathological gamblers in Hong Kong /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B39849120.

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3

Cheng, Wai-kwan Scarlette, and 鄭慧君. "From pathological gambling to help-seeking: cases of female pathological gamblers in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B39849120.

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4

Lu, Dong Juan. "Legal issues of pathological gambling." Thesis, University of Macau, 2008. http://umaclib3.umac.mo/record=b1944063.

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5

Brevers, Damien. "Neurocognitive exploration of pathological gambling." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/241301.

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6

Iannitti, Tommaso. "Obesity, inflammation and pathological pain." Thesis, Glasgow Caledonian University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555680.

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Obesity has become a concern of epidemic proportion and is associated with an increased incidence in chronic pain but the underlying mechanism is not known. Obesity is associated with a low-grade inflammation of white adipose tissue due to a dysregulation in cytokines and adipokines, some of which, including turnor necrosis factor-α and interleukin-1β, have been linked to inflammatory pain. Other adipokines such as adiponectin, display anti- inflammatory properties but their role in modulating inflammatory pain has not been investigated. The aim of this project was to characterise inflammatory pain in the Zucker fatty rat (fa/fa) model of obesity and identify a role for adipokines in mediating this process. It is hypothesised that adipokines, particularly adiponectin, which is lowered on the onset of obesity and possesses anti-inflammatory properties, may account for the differences in pain occurring with obesity. Body weights, blood glucose, plasma lipoproteins and serum triacylglycerol, cholesterol, phospholipids and insulin were measured in adult male lean and obese Zucker rats. Hindpaw withdrawal latency (secs) to thermal stimulation and response threshold (grams) to mechanical stimulation were measured before and after intraplantar injection of carrageenan, capsaicin or hindpaw-incision, and treatment with morphine in lean and obese rats. The effects of recombinant adiponectin or drug-vehicle administered intrathecally or intraplantarly on carrageenan-induced pain and inflammation were also measured in adult male Wistar rats. Expression of adiponectin, adiponectin receptor 1, adiponectin receptor 2, resistin, tumor necrosis factor-a, interleukin-Iβ mRNA in spinal cord, brain and adipose tissues and blood was compared in lean and obese rats and in response to intraplantar injection of carrageenan/saline, using polymerase chain reaction methodologies. Obese Zucker rats had increased body weight, serum cholesterol, phospholipid and insulin levels compared to lean rats. No differences in serum triglyceride levels were observed. Following carrageenan-induced inflammation, obese rats were more sensitive to mechanical and thermal stimulation of the inflamed paw, and displayed greater paw oedema compared to lean rats. No difference in capsaicin- or paw-incision induced-mechanical and thermal hyperalgesia or in morphine-induced analgesia was observed. Adiponectin, resistin, adiponectin receptor 1 and adiponectin receptor 2, tumor necrosis factor-a and interleukin-l P mRNA were all found to be constitutively expressed in spinal cord, brain, adipose tissue and blood. In obese rats adiponectin mRNA was down-regulated in spinal cord compared to lean rats, while an increase was observed in brain tissue. A decrease in adiponectin was also observed in paw tissue from carrageenan-treated Wistar rats compared to saline-treated rats. Intrathecal but not intraplantar injection of recombinant adiponectin inhibited mechanical allodynia and carrageenan-induced peripheral inflammation of the paw. The present study confmns that the Zucker fatty rat is a reliable model of obesity with well defined metabolic characteristics. The increase pain sensitivity and inflammatory response in these rats supports the evidence that obesity is a chronic low-grade inflammatory disorder where further inflammatory challenge leads to an augmented inflammatory and nociceptive response. The results strongly suggest that alterations in adipokine-mediated signalling, in particular involving adiponectin, may account for changes in inflammatory pain occurring with obesity making it a valuable target for pain management in these individuals.

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7

孫耀君 and Yiu-kwan Edmond Suen. "Backward inhibition in pathological gamblers." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41712638.

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8

Suen, Yiu-kwan Edmond. "Backward inhibition in pathological gamblers." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41712638.

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9

DiNicola, Michael D. "Pathological Internet use among college students the prevalance of pathological Internet use and its correlates /." Ohio : Ohio University, 2004. http://www.ohiolink.edu/etd/view.cgi?ohiou1088177898.

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10

DiNicola, Michael D. "Pathological Internet Use among College Students: The Prevalence of Pathological Internet Use and its Correlates." Ohio University / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1088177898.

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11

Schmidt, Ricarda, Mandy Vogel, Andreas Hiemisch, Wieland Kiess, and Anja Hilbert. "Pathological and non-pathological variants of restrictive eating behaviors in middle childhood: A latent class analysis." Elsevier, 2018. https://ul.qucosa.de/id/qucosa%3A34075.

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Although restrictive eating behaviors are very common during early childhood, their precise nature and clinical correlates remain unclear. Especially, there is little evidence on restrictive eating behaviors in older children and their associations with children's shape concern. The present population-based study sought to delineate subgroups of restrictive eating patterns in N = 799 7-14 year old children. Using Latent Class Analysis, children were classified based on six restrictive eating behaviors (for example, picky eating, food neophobia, and eating-related anxiety) and shape concern, separately in three age groups. For cluster validation, sociodemographic and objective anthropometric data, parental feeding practices, and general and eating disorder psychopathology were used. The results showed a 3-cluster solution across all age groups: an asymptomatic class (Cluster 1), a class with restrictive eating behaviors without shape concern (Cluster 2), and a class showing restrictive eating behaviors with prominent shape concern (Cluster 3). The clusters differed in all variables used for validation. Particularly, the proportion of children with symptoms of avoidant/restrictive food intake disorder was greater in Cluster 2 than Clusters 1 and 3. The study underlined the importance of considering shape concern to distinguish between different phenotypes of children's restrictive eating patterns. Longitudinal data are needed to evaluate the clusters' predictive effects on children's growth and development of clinical eating disorders.

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12

Crotti, Tania Narelle. "Mediators of localised pathological bone loss." Title page, table of contents and introduction only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phc9516.pdf.

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Appendum inside back cover. Bibliography: leaves 173-202. This thesis examines localised bone loss, with the focus on bone loss around prosthetic joints in periodontal disease and rheumatoid arthritis. It explores the possibility that bone resorption that is not balanced by bone formation is caused by an abnormal expression of factors that regulate osteoclast formation and activity in the tissue adjacent to the site of pathological bone loss, and seeks to identify these factors in human tissues in situ. It also seeks to elucidate a possible mechanism by which osteolytic mediators induce bone osteolysis in several bone pathologies associated with bone loss. The study shows that the same mechanisms of osteolysis apply to several diseases in humans and suggests that simliar approaches could be used to inhibit osteolysis in localised bone loss.

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13

Wang, Xianfu. "Fine and pathological properties of subdifferentials." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0024/NQ51932.pdf.

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14

Walsh, James Michael. "Spirituality and recovery from pathological gambling." online access from Digital Dissertation Consortium access full-text, 2001. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?3027664.

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15

Lai, Duen-mun, and 黎端敏. "The neuropsychological basis of pathological gambling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46480456.

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16

Leek, Michael David. "Pathological changes induced by ricin poisoning." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252661.

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17

O'Donnell, Rory Anthony. "A clinico-pathological study of COPD." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416068.

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18

Романюк, Анатолій Миколайович, Анатолий Николаевич Романюк, Anatolii Mykolaiovych Romaniuk, Роман Андрійович Москаленко, Роман Андреевич Москаленко, Roman Andriiovych Moskalenko, I. S. Zakorko, Artem Mykhailovych Piddubnyi, Артем Михайлович Піддубний, and Артем Михайлович Поддубный. "Pathological mineralization in the prostate gland." Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27521.

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19

Rumjahn, Sharif Mohamed. "Purinergic regulation of angiogenesis pathological implications /." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3320563.

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20

Bulstra, Sjoerd Klaas. "Histological, pathological and therapeutical aspects of osteoarthritis." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=6500.

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21

Koljenovic, Senada. "Towards clinico-pathological application of Raman spectroscopy." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/11739.

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22

Spauwen, Janneke, Lydia Krabbendam, Roselind Lieb, Hans-Ulrich Wittchen, and Os Jim van. "Sex differences in psychosis: normal or pathological?" Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-110100.

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Background: Schizophrenia first appears in adolescence, in boys at an earlier age than girls. The interpretation of this key epidemiological finding crucially depends on whether similar age-related sex differences exist in the expression of associated, subclinical psychosis-like experiences. Methods: Findings are based on a population sample of 2548 adolescents and young adults aged 17–28. Subjects were assessed with the core psychosis sections on delusions and hallucinations of the Munich- Composite International Diagnostic Interview. Results: The risk of subclinical psychotic experiences was significantly higher for males in the younger half of the cohort (17–21 years), but similar in the older half (22–28 years). Conclusions: These findings suggest that normal maturational changes in adolescence with differential age of onset in boys and girls cause the expression of psychosis, the extreme of which is schizophrenia.

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23

McKerrell, Rosemary. "Labrador retriever myopathy : clinical and pathological investigation." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306555.

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24

Hill, Rebecca Elizabeth. "Pathological changes in diabetic human sural nerve." Thesis, University of Hull, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272080.

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25

Hall, Mandy. "Investigation of pathological biomineralisation using Raman microscopy." Thesis, Northumbria University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384965.

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26

Underdown, Simon John. "A comparative pathological analysis of Neanderthal Palæotrauma." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607965.

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27

HajMohammadi, Sassan. "Development of FISH technology in pathological tissue." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284578.

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28

Di, Alberti Luca. "Human herpesvirus 8 and new pathological associations." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300031.

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29

Shepherd, Neil Anthony. "Pathological and prognostic correlations in intestinal cancer." Thesis, Cranfield University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426091.

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30

Chen, Walter W. "Pathological features of mitochondrial respiratory chain dysfunction." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104099.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2016.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis. "June 2016."
Includes bibliographical references.
Mitochondria are essential organelles that carry out a multitude of important metabolic processes in mammalian organisms. These processes include ATP generation by the respiratory chain, aspartate synthesis by matrix aminotransferases, and long-chain fatty acid catabolism by the beta oxidation pathway. Given the role of mitochondria in maintaining cellular physiology, mitochondrial dysfunction often leads to disease. One major class of mitochondrial pathologies is caused by defects in the mitochondrial respiratory chain (RC). Yet while the genetic etiologies of these RC disorders are well-studied, the molecular defects that actually link RC dysfunction with impaired cellular viability are still unclear. In the work described here, we demonstrate that loss of mitochondrial membrane potential and aspartate contributes significantly to cellular pathology during RC dysfunction. In addition, we develop a novel method for rapidly isolating mitochondria and profiling their metabolite contents to study the changes in mitochondrial metabolism across various states of RC function. From this work, we find numerous alterations in matrix metabolites that had been previously unappreciated using traditional profiling of whole-cells and identify new metabolic abnormalities downstream of RC dysfunction. Collectively, this work uncovers distinct molecular events connecting RC pathology with impaired cellular viability and expands our understanding of the metabolic processes affected by RC dysfunction, thus opening up new areas for exploration.
by Walter W. Chen.
Ph. D.

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31

Griggs, Jeremy. "Effects of combretastatin-A4 on pathological angiogenesis." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621347.

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32

Yates, Matthew. "Studies on macrophage migration in pathological contexts." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/53465/.

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Macrophages play key roles following nerve injury releasing cytokines and chemokines thought to be involved in the development and maintenance of neuropathic pain. ATP is a transporter of chemical energy, but can also act as an extracellular signalling molecule that signals through purinergic receptors. ATP, probably released from damaged neurons, can promote the migration of macrophages and microglia to the site of injury, and can be responsible for the onset of neuropathic pain. Purinergic signalling via ATP and other nucleotides is now well established and increasing evidence suggests that ATP could play important roles in pathophysiology. The neuroprotective neurotrophin brain derived neurotrophic factor (BDNF) inhibited ATP-induced invasion of macrophages though an extracellular matrix. The well-characterised Sigma-1 Receptor chaperone, previously implicated in BDNF function, was shown to be an important overall regulator of macrophage invasion, and to be potentially implicated in BDNF suppression of ATP-induced invasion. BDNF may thus have a neuroprotective role to inhibit further macrophage recruitment to the site of injury. Matrix metalloproteinases (MMPs) are capable of remodelling the extracellular matrix and the activation of inflammatory mediators. Exploration of MMP responses to extracellular ATP stimulation in a macrophage cell line revealed that MMPs -8, -12, and-13 as well as TIMP-2 steady state mRNA levels were significantly up-regulated ATP, ATP can alter matrix remodelling. Macrophage recruitment is a significant player in atherosclerosis and may be modulated by Apolipoprotein E genotype. N3-polyunsaturated fatty acids (obtained from dietary fish oils) have been implicated in cardiovascular protection. Using a high fat diet model the effects of dietary fish oil supplementation and Apolipoprotein E subtype were explored in ex vivo primary macrophages. Unexpectedly, a fish oil supplemented diet led increased macrophage migration speed and reduced TIMP-2 mRNA levels, suggesting that fish oil supplements play complex roles in atherosclerotic-related scenarios.

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33

Kolodziejczyk, K. "Electrical responses of oligodendrocytes to pathological stimuli." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324543/.

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The white matter is crucial for rapid transmission of information between different parts of the brain and spinal cord, and is damaged in diseases including the genetic leukodystrophies, stroke, spinal cord injury and multiple sclerosis. While damage in the grey matter of the CNS is well known to often involve over-activation of glutamate receptors, our understanding of white matter pathology is less advanced. The experiments in this thesis used patch-clamping and [Ca2+]i imaging to examine the cerebellar white matter oligodendrocyte response to pathological insults mimicking those occurring in the leukodystrophies and in the ischaemia that occurs in stroke or after spinal cord injury. Oligodendrocytes responded to simulated ischaemia with an inward current, which was triggered by glutamate release mediated by reversal of glutamate transporters, and not by exocytosis, NKCC1 or cystine/glutamate exchange. Surprisingly, this inward current was not mediated by glutamate receptors, nor by ASICs, gap junctional hemichannels, P2X receptors or GABAA receptors, but reflected the closing of potassium channels. In current clamp mode this initial closing of K+ channels produced a depolarisation of the cells, followed by a repolarisation as other K+ channels activated. These data indicate, for the first time, a significant role for K+ channels in the response of oligodendrocytes to ischaemia. In Canavan and Pelizaeus-Merzbacher-like leukodystrophies, elevated levels of Nacetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) occur. These compounds can activate or block neuronal NMDA receptors. Since oligodendrocytes are reported to express NMDA receptors, I tested their response to NAAG and NAA. NAAG, but not NAA, evoked a small inward NMDA receptor-mediated current in oligodendrocytes, but no [Ca2+]i rise. Much of the inward current was a secondary effect of NAAG acting on neurons. Thus, actions of NAAG and NAA on oligodendrocyte NMDARs are unlikely to be a major contributor to white matter damage in the leukodystrophies.

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34

Spauwen, Janneke, Lydia Krabbendam, Roselind Lieb, Hans-Ulrich Wittchen, and Os Jim van. "Sex differences in psychosis: normal or pathological?" Technische Universität Dresden, 2003. https://tud.qucosa.de/id/qucosa%3A26811.

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Background: Schizophrenia first appears in adolescence, in boys at an earlier age than girls. The interpretation of this key epidemiological finding crucially depends on whether similar age-related sex differences exist in the expression of associated, subclinical psychosis-like experiences. Methods: Findings are based on a population sample of 2548 adolescents and young adults aged 17–28. Subjects were assessed with the core psychosis sections on delusions and hallucinations of the Munich- Composite International Diagnostic Interview. Results: The risk of subclinical psychotic experiences was significantly higher for males in the younger half of the cohort (17–21 years), but similar in the older half (22–28 years). Conclusions: These findings suggest that normal maturational changes in adolescence with differential age of onset in boys and girls cause the expression of psychosis, the extreme of which is schizophrenia.

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35

Romero, Prieto Martha Liliana. "Expression analysis of micrornas in pathological contexts." Paris 7, 2014. http://www.theses.fr/2014PA077001.

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La maladie est le résultat d'une interaction entre facteurs géntiques et environnementaux. Cette interaction peut être modulée par des mécanismes épigénétiques. Le contrôle de l'expression des gènes par les microARN dans les conditions physiologiques et dans des conditions pathologiques est fascinant. Nous avons étudié la connexion entre l'expression dérégulée de miRs et les répercussions cellulaires induites dans différentes pathologies. Dans l'anémie de Fanconi, nous avons démontré que la surexpression de miR-34a, une cible de p53, est associée à une apoptose accrue, en particulier dans la GVHD sévère, cet effet est p53 indépendant. L'existence d'un mécanisme non-canonique avant la réponse aux dommages de l'ADN reste à explorer. Dans le cancer de la prostate, nous avons démontré que la perte d'expression de miR-200, miR-34a et miR-145, chez les patients à haut risque, était présente dans les PIN de haut grade. Ces altérations expliqueraient l'activation du processus de transition épithelio-mésenchymateuse. Ainsi, la modification précoce de l'expression de ces miRs pourrait être une voie motrice de la progression du cancer de la prostate vers la maladie métastatique. Dans les lymphomes B médiastinaux, nous avons trouvé des dérégulations de miRs appartenant à miR-17-92. Basé sur les prévisions et les analyses bioinformatiques et transcriptomiques, nous avons identifié de nouvelles cibles nécessitant des validations expérimentales, qui contribueront à la compréhension du rôle des mirs dans la lymphomagenèse. En conclusion, l'étude des miRs dans différentes situations pathologiques est une approche prometteuse pour une meilleure compréhension des mécanismes de la maladie
Disease is result of an intricate interaction between genetic and environmental factors. However this interaction is not straightforward, it can be modulated by epigenetic mechanisms. The tight control of gene expression by microRNAs in physiological conditions and its disruption in pathological conditions represents a fascinating example. We investigated connection between deregulated expression of miRs and their related cellular outcomes in different pathological contexts. In Fanconi-Anemia, we found that overexpression of miR-34a, a target of p53, is associated with increased apoptosis, particularly in severe GVHD. We found that this effect was p53-independent, providing evidence for the existence of a non-canonical mechanism downstream the DNA damage response that remains entirely to be explored. In Prostate-Cancer, we found that loss of expression of miR-200, miR-34a and miR-145, particularly in high risk patients, is present in high grade PIN, a pre-invasive stage. These alterations might account for the activation of the EMT program, key feature of the malignant phenotype. Thus, early alteration in the expression of these miRs could be a driving force for the progression of prostate cancer towarddd the metastatic disease. In Mediastinal B-Cell Lymphoma, we found distinct deregulations of miRs belonging to miR-17-92. Based on bioinformatic predictions and integrative transcriptomic analyses, we succeed in indentifying new potential targets for further experimental validation, contributing to understand role of these miRs in lymphomagenesis. In conclusion, studying miRs in pathological settings is a valuable approach for a better comprehension of mechanisms of disease

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36

Shevchenko, Tetiana Volodymyrivna, T. V. Yashchenko, Тетяна Володимирівна Шевченко, and Татьяна Владимировна Шевченко. "Pathological placental implantation and previous cesarean section." Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27534.

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Scientific supervisor: V.I. Boyko
Placenta accreta and previa are major causes of massive obstetric hemorrhage. Abnormal placentation remains responsible for peripartum hysterectomies. Present-day is the hypothesis that previous cesarean section increases the likelihood of abnormal placentation. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/27534

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37

Embleton, Sally J. "Physiological and pathological human ocular perfusion characteristics." Thesis, Aston University, 2002. http://publications.aston.ac.uk/14558/.

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There were three principle aims to this thesis. Firstly, the acquisition protocols of clinical blood flow apparatus were investigated in order to optimise them for both cross-sectional and longitudinal application. Secondly, the effects of physiological factors including age and systematic circulation on ocular blood flow were investigated. Finally, the ocular perfusion characteristics of patients diagnosed with ocular diseases considered to be of a vascular origin were investigated. The principle findings of this work are:- 1) Optimisation of clinical investigations Photodiode sensitivity of the scanning laser Doppler flowmeter should be kept within a range of 70-150 DC when acquiring images of the retina and optic nerve head in order to optimise the reproducibility of capillary blood flow measures. Account of the physiological spatial variation in retinal blood flow measures can be made using standard analysis protocols of the scanning laser Doppler flowmeter combined with a local search strategy. Measurements of pulsatile ocular blood flow using the ocular blood flow analyser are reproducible, however this reproducibility can be improved when consecutive intraocular pressure pulses are used to calculate pulsatile ocular blood flow. Spectral analysis of the intraocular pressure pulse-wave is viable and identifies the first four harmonic components of the waveform. 2) Physiological variation in ocular perfusion Age results in a significant reduction in perfusion of the retinal microcirculation, which is not evident in larger vessel beds such as the choroid. Despite known asymmetry in the systemic vasculature, no evidence of interocular asymmetry in ocular perfusion is apparent. 3) Pathological variation in ocular perfusion In primary open angle glaucoma, perfusion is reduced in the retinal microcirculation of patients classified as having early to moderate visual field defects. However, ocular pulsatility defects are masked when patients and subjects are matched for systemic variables (pulse rate and mean arterial pressure); differentiation is facilitated by the application of waveform analysis to the continuos intraocular pressure curve even in the early stages of disease. Diabetic patients with adequate glycaemic control, exhibit maintenance of macular blood flow, macular topography and visual function following phacoemulsification.

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38

Ashraf, Pouya. "Pathological functions and the Baire category theorem." Thesis, Uppsala universitet, Analys och sannolikhetsteori, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322944.

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39

Liu, Xiaoqiu. "Microscopic tissue image processing for pathological evaluation /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999304.

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40

Johnston, G. J. "A computer model for investigating the biomechanical effects of radiation exposure on pathological and non-pathological living human cells." Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/6668/.

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The cellular response to radiation insult and studies have been carried out to investigate aspects of the cytoskeleton and the force response of the cell when probed by an AFM. Confirmed for the first time that there was a statistically significant difference for the PNT2 and PC3 cell lines in response to probing with the AFM tip, and that time was eliminated a possible influencing factor in the short term (1 hour) for the force response. Showed that the Hertz model is not sufficient for distances greater than 500nm due to the strain hardening effect for biological cells and that the biological cells non-linear force response becomes marked after the 500nm region. The orientation of actin was investigated and a bimodal variation was statistical significant, although the larger tendency was for a 90 degree separation there was indications that earlier theoretical work by Pollard, 2008 was present. The importance of the contact point when considering the cell lines PNT2, DU145 and PC3 and greater than 500nm indentation is shown and four different methods are tested and the most robust of these chosen as the method for the distance and cell lines involved. That being ‘line projection’ method created by the author. A method that normalises the data for AFM force curves is presented, the method minimises the contact point error at the same time and therefore provides biologists with a way to test cell lines using standard normal population tests.

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41

Kwong, Yee-wa Eva. "An inquiry into guilt and shame in psychopathology: an exploratory study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B29653009.

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42

O'Dowd, S. A. "The interpersonal dimension of psychopathology." Thesis, Rhodes University, 1987. http://hdl.handle.net/10962/d1002075.

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It is argued that two large groups of disorders can be distinguished in the field of psychopathology, (1) which divide between them the psychoses, neuroses and personality disorders; ( 2) the dynamics of which are those of Klein's paranoid-schizoid and depressive positions, respectively; and (3) which are distinguished by nine basic contrasts in symptomatology and dynamics, all of which are expressive of the opposition self-centred/other-centred. These three hypotheses form the interpersonal model of psychopathology, and are supported by argument from works of Foulds, Jung, Abraham, Fairbairn, Klein, Angyal, Winnicott and Heidegger. It is suggested that the interpersonal model can facilitate the dialogue between psychoanalysis and phenomenology

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Niu, Feng. "Human Activity Recognition and Pathological Gait Pattern Identification." Scholarly Repository, 2007. http://scholarlyrepository.miami.edu/oa_dissertations/247.

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Human activity analysis has attracted great interest from computer vision researchers due to its promising applications in many areas such as automated visual surveillance, computer-human interactions, and motion-based identification and diagnosis. This dissertation presents work in two areas: general human activity recognition from video, and human activity analysis for the purpose of identifying pathological gait from both 3D captured data and from video. Even though the research in human activity recognition has been going on for many years, still there are many issues that need more research. This includes the effective representation and modeling of human activities and the segmentation of sequences of continuous activities. In this thesis we present an algorithm that combines shape and motion features to represent human activities. In order to handle the activity recognition from any viewing angle we quantize the viewing direction and build a set of Hidden Markov Models (HMMs), where each model represents the activity from a given view. Finally, a voting based algorithm is used to segment and recognize a sequence of human activities from video. Our method of representing activities has good attributes and is suitable for both low resolution and high resolution video. The voting based algorithm performs the segmentation and recognition simultaneously. Experiments on two sets of video clips of different activities show that our method is effective. Our work on identifying pathological gait is based on the assumption of gait symmetry. Previous work on gait analysis measures the symmetry of gait based on Ground Reaction Force data, stance time, swing time or step length. Since the trajectories of the body parts contain information about the whole body movement, we measure the symmetry of the gait based on the trajectories of the body parts. Two algorithms, which can work with different data sources, are presented. The first algorithm works on 3D motion-captured data and the second works on video data. Both algorithms use support vector machine (SVM) for classification. Each of the two methods has three steps: the first step is data preparation, i.e., obtaining the trajectories of the body parts; the second step is gait representation based on a measure of gait symmetry; and the last step is SVM based classification. For 3D motion-captured data, a set of features based on Discrete Fourier Transform (DFT) is used to represent the gait. We demonstrate the accuracy of the classification by a set of experiments that shows that the method for 3D motion-captured data is highly effective. For video data, a model based tracking algorithm for human body parts is developed for preparing the data. Then, a symmetry measure that works on the sequence of 2D data, i.e. sequence of video frames, is derived to represent the gait. We performed experiments on both 2D projected data and real video data to examine this algorithm. The experimental results on 2D projected data showed that the presented algorithm is promising for identifying pathological gait from video. The experimental results on the real video data are not good as the results on 2D projected data. We believe that better results could be obtained if the accuracy of the tracking algorithm is improved.

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Becher, Julie-Clare. "Epidemiological and pathological correlates of early neonatal mortality." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29120.

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Objectives: An aim of this project was to identify clinical and genetic risk factors for early neonatal mortality within the Scottish population with special consideration to those infants born in an asphyxiated condition. A further aim was to determine the prevalence of antenatal brain injury within this population and to correlate neuropathology with clinical factors. Methods: Clinical data and neuropathological specimens were collected as part of the Scottish National Perinatal Neuropathology Study from all 22 delivery units throughout Scotland. Birth asphyxia was defined and infants were classified accordingly. Neuropathological examination was performed by a single observer in Edinburgh blind to clinical detail. Apolipoprotein E genotype was analysed and compared with known published data for adults and healthy newborns. Comparisons of categorical data were made with the Chi-square test and numerical data were compared using the unpaired student’s t-test and Mann Whitney U test. Results: Clinical data was collected from 191 early neonatal deaths. Complications of pregnancy were common in all neonatal deaths. The only predictive factors for asphyxia were indicators of intrapartum fetal distress. Neuropathological examination was possible in 59 infants surviving 3 days or less. Evidence of prelabour brain injury was observed in nearly half of this cohort, and this was significantly more common in asphyxiated infants and those who developed an encephalopathy. The only clinical associations of such damage were the presence of cardiotocograph abnormalities, meconium staining and severe depression at birth. Apolipoprotein E analysis was performed in 252 perinatal deaths. There was an over representation of the ε4 allele among healthy newborns compared to perinatal deaths and adults.

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Doiron, Jason. "Prevention of pathological gambling a randomized controlled trial /." access full-text online access from Digital Dissertation Consortium, 2005. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?NR25497.

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Perkins, Ayana N. "An Exploration of Pathological Gambling Among Diverse Populations." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/psych_diss/99.

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This study used an ecological perspective to identify pathological gambling (PG) risk and protective factors, nonclinical resources, and prevention strategies based on the perceptions of Georgia stakeholders. With an ecological perspective, human behavior is perceived as an outcome of the interaction between the individual and various factors in their social environment. The ecological perspective is especially suitable for examining the higher PG prevalence among ethnic minority groups since these populations have been documented as encountering greater exposure to PG social and environmental risk factors (Smedley & Syme, 2000). To assess prevention needs, data were obtained from a 2008 needs assessment where diverse perspectives were collected through semi structured focus groups and interviews. A qualitative approach was used to address the study's aims. Grounded theory was used to guide the data analysis. Findings indicated that community perceptions of risk and protective factors, nonclinical resources, and prevention strategies were present at multiple levels of analyses. Furthermore, data trends also indicated that charitable gambling and other social norms should be considered in prevention.

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Sharpe, Tammy. "Pathological triplet repeat expansions and chromosomal position effects." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406796.

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Cooper, P. N. "Pathological changes in dementia due to lobar atrophy." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359985.

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Pearson, Joanne. "The pathological role of Th2 cytokines in artherosclerosis." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419321.

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du, Toit Nicole. "Anatomical, pathological and clinical study of donkey teeth." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4385.

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Eighty normal cheek teeth and 26 normal incisors extracted from 14 donkeys (median age 19 years) at post mortem were anatomically examined including grossly and by computerised axial tomography (CAT) imaging. Decalcified histology was performed on 54 sections from 18 teeth (8 donkeys), undeclacified histology on 16 sections from 7 donkeys and scanning electron microscopy on 10 sections from 10 teeth (3 donkeys). The dental formulae and tooth number was found to be the same as in horses with a higher prevalence (17 %) of canine teeth in female donkeys. A decrease in tooth length, pulp horn length and pulp horn width with age was illustrated, as was an increase in occlusal secondary dentine depth with age, although not all these age changes were statistically significant. Normal histological and ultrastructural features of donkey teeth were identified and found to be similar to equine findings. Enamel was found to be thicker buccally in both maxillary and mandibular cheek teeth. Quantitative measurements of transverse dentine thickness around pulp cavities, dentinal tubule diameters and densities, and enamel prism diameters were made. Left lower incisors (301) were extracted from 7 donkeys and 6 horses for micro-hardness determination of enamel, primary and secondary dentine using a Knoop Hardness indenter. No significant difference between donkey and horse incisor microhardness was demonstrated. Examination of 19 donkey skulls at post mortem examination showed donkeys to have a higher degree of anisognathia (27%) compared to horses (23%). Post mortem dental examination of 349 donkeys (median age 31) demonstrated a high prevalence of dental disease (93%) and in particular cheek teeth diastemata (85%). Furthermore, age was associated with increasing prevalence of dental disease and diastemata. Diastemata were also associated with the presence of other dental disorders and with colic-related death in affected donkeys. Quantitative measurements of 45 diastemata from 16 donkeys showed no difference in the medial and lateral width of diastemata but periodontal pockets were deeper laterally. The definition of valve and open diastemata were confirmed. Pulp exposure, dental caries and periodontal disease were examined in detail (54 skulls) at post mortem. A total of 19 teeth were extracted for further detailed examination as performed in normal anatomy. Clinical dental examinations were performed on 357 donkeys in the U.K. that were selected for age distribution, and the prevalence of dental disease in different age groups was found to increase from 28% in the youngest group (age 0-10 years) to 98% in the oldest group (age > 35 years). An increased prevalence of most dental disorders with age was demonstrated as was an association between dental disease and weight loss, poor body condition score, supplemental feeding and previous episodes of colic. Clinical dental examination of 203 working donkeys in Mexico showed similar types of dental disorders as found in the U.K. study, with dental disease present in 62%, of which 18% required urgent dental treatment. There was a significant association between age groups and dental disease, and age groups and body condition score, but there was no association between dental disease and body condition score. However, body condition score was not associated with supplemental feeding or faecal egg counts either.

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