Academic literature on the topic 'Patched Gene'
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Journal articles on the topic "Patched Gene"
Ellis, Tammy, Ian Smyth, Emily Riley, Scott Graham, Kate Elliot, Monica Narang, Graham F. Kay, Carol Wicking, and Brandon Wainwright. "Patched 1 conditional null allele in mice." genesis 36, no. 3 (July 2003): 158–61. http://dx.doi.org/10.1002/gene.10208.
Full textPhillips, R. G., I. J. Roberts, P. W. Ingham, and J. R. Whittle. "The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs." Development 110, no. 1 (September 1, 1990): 105–14. http://dx.doi.org/10.1242/dev.110.1.105.
Full textIngham, Philip W. "The patched gene in development and cancer." Current Opinion in Genetics & Development 8, no. 1 (February 1998): 88–94. http://dx.doi.org/10.1016/s0959-437x(98)80067-1.
Full textIngham, Philip W. "The patched gene in development and cancer." Current Opinion in Genetics & Development 8, no. 3 (June 1998): 371. http://dx.doi.org/10.1016/s0959-437x(98)80096-8.
Full textHidalgo, A., and P. Ingham. "Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched." Development 110, no. 1 (September 1, 1990): 291–301. http://dx.doi.org/10.1242/dev.110.1.291.
Full textMarigo, V., M. P. Scott, R. L. Johnson, L. V. Goodrich, and C. J. Tabin. "Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb." Development 122, no. 4 (April 1, 1996): 1225–33. http://dx.doi.org/10.1242/dev.122.4.1225.
Full textConcordet, J. P., K. E. Lewis, J. W. Moore, L. V. Goodrich, R. L. Johnson, M. P. Scott, and P. W. Ingham. "Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning." Development 122, no. 9 (September 1, 1996): 2835–46. http://dx.doi.org/10.1242/dev.122.9.2835.
Full textCapdevila, J., F. Pariente, J. Sampedro, J. L. Alonso, and I. Guerrero. "Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos." Development 120, no. 4 (April 1, 1994): 987–98. http://dx.doi.org/10.1242/dev.120.4.987.
Full textIngham, P. W., A. M. Taylor, and Y. Nakano. "Role of the Drosophila patched gene in positional signalling." Nature 353, no. 6340 (September 1991): 184–87. http://dx.doi.org/10.1038/353184a0.
Full textTakabatake, Takashi, Masanori Ogawa, Tadashi C. Takahashi, Makoto Mizuno, Mitsumasa Okamoto, and Kazuhito Takeshima. "Hedgehog and patched gene expression in adult ocular tissues." FEBS Letters 410, no. 2-3 (June 30, 1997): 485–89. http://dx.doi.org/10.1016/s0014-5793(97)00645-5.
Full textDissertations / Theses on the topic "Patched Gene"
Rahnama, Fahimeh. "Molecular complexities of patched signaling in cancer development /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-897-1/.
Full textHidalgo-Downing, Alicia. "Molecular cloning of patched and analysis of its role in intrasegmental patterning in D. melanogaster." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258158.
Full textUndén, Anne Birgitte. "Studies on basal cell carcinoma with emphasis on the role of the human homologue of the drosophila patched gene /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2788-X.
Full textde, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3878.
Full textde, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin." University of Sydney, 2008. http://hdl.handle.net/2123/3878.
Full textBCC is the commonest cancer in European-derived populations and Australia has the highest recorded incidence in the world, creating enormous individual and societal cost in management of this disease. The incidence of this cancer has been increasing internationally, with evidence of a 1 to 2% rise in incidence in Australia per year over the last two decades. The main four epidemiological risk factors for the development of BCC are ultraviolet radiation (UVR) exposure, increasing age, male sex, and inability to tan. The pattern and timing of UVR exposure is important to BCC risk, with childhood and intermittent UVR exposure both associated with an increased risk. The complex of inherited characteristics making up an individual’s ‘sun sensitivity’ is also important in determining BCC risk. Very little is known about population genetic susceptibility to BCC outside of the rare genodermatosis Gorlin syndrome. Mutations in the tumour suppressor gene patched (PTCH) are responsible for this BCC predisposition syndrome and the molecular pathway and target genes of this highly conserved pathway are well described. Derangments in this pathway occur in sporadic BCC development, and the PTCH gene is an obvious candidate to contribute to non-syndromic susceptibility to BCC. The melanocortin 1 receptor (MC1R) locus is known to be involved in pigmentary traits and the cutaneous response to UVR, and variants have been associated with skin cancer risk. Many other genes have been considered with respect to population BCC risk and include p53, HPV, GSTs, and HLAs. There is preliminary evidence for specific familial aggregation of BCC, but very little known about the causes. 56 individuals who developed BCC under the age of 40 in the year 2000 were recruited from the Skin and Cancer Foundation of Australia’s database. This represents the youngest 7 – 8% of Australians with BCC from a database that captures approximately 10% of Sydney’s BCCs. 212 of their first degree relatives were also recruited, including 89 parents and 123 siblings of these 56 probands. All subjects were interviewed with respect to their cancer history and all reports of cancer verified with histopathological reports where possible. The oldest unaffected sibling for each proband (where available) was designated as an intra-family control. All cases and control siblings filled out a questionnaire regarding their pigmentary and sun sensitivity factors and underwent a skin examination by a trained examiner. Peripheral blood was collected from these cases and controls for genotyping of PTCH. All the exons of PTCH for which mutations have been documented in Gorlin patients were amplified using PCR. PCR products were screened for mutations using dHPLC, and all detectable variants sequenced. Prevalence of BCC and SCC for the Australian population was estimated from incidence data using a novel statistical approach. Familial aggregation of BCC, SCC and MM occurred within the 56 families studied here. The majority of families with aggregation of skin cancer had a combination of SCC and BCC, however nearly one fifth of families in this study had aggregation of BCC to the exclusion of SCC or MM, suggesting that BCCspecific risk factors are also likely to be at work. Skin cancer risks for first-degree relatives of people with early onset BCC were calculated: sisters and mothers of people with early-onset BCC had a 2-fold increased risk of BCC; brothers had a 5-fold increased risk of BCC; and sisters and fathers of people with early-onset BCC had over four times the prevalence of SCC than that expected. For melanoma, the increased risk was significant for male relatives only, with a 10-fold increased risk for brothers of people with early-onset BCC and 3-fold for fathers. On skin examination of cases and controls, several phenotypic factors were significantly associated with BCC risk. These included increasing risk of BCC with having fair, easyburning skin (ie decreasing skin phototype), and with having signs of cumulative sun damage to the skin in the form of actinic keratoses. Signs reflecting the combination of pigmentary characteristics and sun exposure - in the form of arm freckling and solar lentigines - also gave subjects a significantly increased risk BCC. Constitutive red-green reflectance of the skin was associated with decreased risk of BCC, as measured by spectrophotometery. Other non-significant trends were seen that may become significant in larger studies including associations of BCC with propensity to burn, moderate tanning ability and an inability to tan. No convincing trend for risk of BCC was seen with the pigmentary variables of hair or eye colour, and a non-significant reduced risk of BCC was associated with increasing numbers of seborrhoeic keratoses. Twenty PTCH exons (exons 2, 3, 5 to 18, and 20 to 23) were screened, accounting for 97% of the coding regions with published mutations in PTCH. Nine of these 20 exons were found to harbour single nucleotide polymorphisms (SNPs), seen on dHPLC as variant melting curves and confirmed on direct sequencing. SNPs frequencies were not significantly different to published population frequencies, or to Australian general population frequencies where SNP database population data was unavailable. Assuming a Poisson distribution, and having observed no mutations in a sample of 56, we can be 97.5% confident that if there are any PTCH mutations contributing to early-onset BCC in the Australian population, then their prevalence is less than 5.1%. Overall, this study provides evidence that familial aggregation of BCC is occurring, that first-degree relatives are at increased risk of all three types of skin cancer, and that a combination of environmental and genetic risk factors are likely to be responsible. The PTCH gene is excluded as a major cause of this increased susceptibility to BCC in particular and skin cancer in general. The weaknesses of the study design are explored, the possible clinical relevance of the data is examined, and future directions for research into the genetics of basal cell carcinoma are discussed.
Daniels, Graeme P. "Characterisation of the Musca domestica (Diptera) homologue of the Drosophila melanogaster segment polarity gene patched, and the cloning of a cDNA fragment, PD, from Acheta domesticus." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/13559.
Full textDiniz, Marina Goncalves. "Estudo das múltiplas isoformas do gene Patched1 em ceratocisto odontogênico." Universidade Federal de Minas Gerais, 2008. http://hdl.handle.net/1843/BUOS-9TDFHF.
Full textPoon, Hiu-ching. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 enteric gene in the enteric neural crest cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841604.
Full textCordeiro, Erick M. G. "Patterns of infestation, dispersion, and gene flow in Rhyzopertha dominica based on population genetics and ecological modeling." Diss., Kansas State University, 2016. http://hdl.handle.net/2097/32642.
Full textDepartment of Entomology
James F. Campbell
Thomas W. Phillips
Movement is a fundamental feature of animals that impacts processes across multiple scales in space and time. Due to the heterogeneous and fragmented nature of habitats that make up landscapes, movement is not expected to be random in all instances, and an increase in fitness is an expected consequence for those that can optimize movement to find valuable and scarce recourses. I studied the movement of Rhyzopertha dominica (Coleoptera: Bostrichidae), one of the most important pests of stored grain worldwide, within and between resource patches. At a fine spatial scale, I identified factors that contribute to overall and upward movement in the grain mass. Three-week-old insects tented to stay closer to the surface than one or two-week-old insects. Females tended to be more active and to explore more than males. I also found that males tended to stay closer to the surface than females and that might be related to the ability to attract females from outside the patch since there was no significant difference regarding female’s attraction within the grain patch. Interaction with feeding sites or other individuals of the same sex creates positive feedback and a more clumped spatial pattern of feeding and foraging behavior. On the other hand, interaction with individuals of different sex creates negative feedback and a more random or overdispersed pattern. At a broad spatial scale, I studied the long-term consequence of R. dominica movement on the development of population structure within the U.S. To evaluate population structure, I used reduced representation of the genome followed by direct sequencing of beetles collected from different locations across the U.S where wheat or rice is produced and stored. Ecoregions were more important in explaining structure of R. dominica populations than crop type. I also found significant isolation by distance; however, model selection primarily elected grain production and movement variables to explain population differentiation and diversity. Understanding animal movement is essential to establishing relationships between distribution and surrounding landscape, and this knowledge can improve conservation and management strategies.
Liang, Guihua. "K⁺ channels in the inner ear : electrophysiological and molecular studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7349-971-4/.
Full textBooks on the topic "Patched Gene"
Shrewsbury, Stephen. Defy Your DNA: How the New Gene Patch Personalized Medicines Will Help You Overcome Your Greatest Health Challenges. 10 Finger Press, 2013.
Find full textBook chapters on the topic "Patched Gene"
Weinstein, P. D., P. A. Schweitzer, A. George, and J. J. Cebra. "Expression of heavy chain genes is restricted in Peyer’s patch germinal center B cells." In Advances in Mucosal Immunology, 302–5. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-1848-1_85.
Full textLemtiri-Chlieh, Fouad, and Rashid Ali. "Characterization of Heterologously Expressed Transporter Genes by Patch- and Voltage-Clamp Methods: Application to Cyclic Nucleotide-Dependent Responses." In Cyclic Nucleotide Signaling in Plants, 67–93. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-441-8_6.
Full textAllendorf, Fred W., W. Chris Funk, Sally N. Aitken, Margaret Byrne, and Gordon Luikart. "Population Connectivity." In Conservation and the Genomics of Populations, 425–50. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780198856566.003.0019.
Full textLevitan, Irwin B., and Leonard K. Kaczmarek. "Diversity in the Structure and Function of Ion Channels." In The Neuron, 127–50. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199773893.003.0007.
Full textFain, Gordon L. "The senses." In Sensory Transduction, 1–17. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198835028.003.0001.
Full textLondon, Bette. "Material Boys." In Posthumous Lives, 33–71. Cornell University Press, 2022. http://dx.doi.org/10.7591/cornell/9781501762352.003.0002.
Full textYeh, Hermes, Stavros Therianos, and Shao-Ming Lu. "Combining Patch-Clamp Recording and Gene Profiling in Single Neurons." In Methods in Alcohol-Related Neuroscience Research. CRC Press, 2002. http://dx.doi.org/10.1201/9781420042092.ch4.
Full textThompson, Daniel B. "Different Spatial Scales of Natural Selection and Gene Flow: The Evolution of Behavioral Geographic Variation and Phenotypic Plasticity." In Geographic Variation in Behavior. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780195082951.003.0006.
Full text"Community Ecology of Stream Fishes: Concepts, Approaches, and Techniques." In Community Ecology of Stream Fishes: Concepts, Approaches, and Techniques, edited by William J. Matthews. American Fisheries Society, 2010. http://dx.doi.org/10.47886/9781934874141.ch1.
Full text"Correlation of Ion Channel Activity with Gene Expression Using Single-Cell RT-PCR and Patch-Clamp Techniques." In Ion Channels in the Pulmonary Vasculature, 690–701. CRC Press, 2005. http://dx.doi.org/10.1201/b14190-35.
Full textConference papers on the topic "Patched Gene"
Ramalingam, Naveen, Long-Qing Chen, Xin-Hao Yang, Liqun Deng, Qing-Hui Wang, Eric Yap Peng Huat, Chiew Hoon Neo, and Hai-Qing Gong. "A Surface-Directed Microfluidic Scheme for Parallel Nanoliter PCR Array Suitable for Point-of-Care Testing." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82052.
Full textChiu, Chun-Chia, Jeng-Lin Li, Yu-Fen Wang, Bor-Sheng Ko, and Chi-Chun Lee. "A Coarse-to-Fine Pathology Patch Selection for Improving Gene Mutation Prediction in Acute Myeloid Leukemia." In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871814.
Full textHuitema, L., J. L. Valdes, H. Wong, and A. Crunteanu. "Optical Switching of GeTe Phase Change Material: Application to a Frequency Agile Millimeter-Waves Patch Antenna." In 12th European Conference on Antennas and Propagation (EuCAP 2018). Institution of Engineering and Technology, 2018. http://dx.doi.org/10.1049/cp.2018.0888.
Full textReports on the topic "Patched Gene"
Montville, Thomas J., and Roni Shapira. Molecular Engineering of Pediocin A to Establish Structure/Function Relationships for Mechanistic Control of Foodborne Pathogens. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568088.bard.
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