Log in

Relevant bibliographies by topics / Paschen curve / Journal articles

Journal articles on the topic 'Paschen curve'

To see the other types of publications on this topic, follow the link: Paschen curve.

Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Paschen curve.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

BURM, K. T. A. L. "Paschen curves for metal plasmas." Journal of Plasma Physics 78, no. 2 (December 16, 2011): 199–202. http://dx.doi.org/10.1017/s0022377811000572.

Full text

Abstract:

AbstractThe Paschen curve for D.C. electric field-driven sources like conductively coupled plasmas is examined. The considered plasma gases are metals. The minimum breakdown requirement is related to the ionization energy and the collision cross section of the considered plasma. The dominant collisions to consider may depend on the plasma source.

APA, Harvard, Vancouver, ISO, and other styles

2

Lee, S. M., Y. S. Seo, and J. K. Lee. "Paschen breakdown curve by one-dimensional PIC-MCC simulation." Computer Physics Communications 177, no. 1-2 (July 2007): 132. http://dx.doi.org/10.1016/j.cpc.2007.02.057.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Burm, K. T. A. L. "Calculation of the Townsend Discharge Coefficients and the Paschen Curve Coefficients." Contributions to Plasma Physics 47, no. 3 (May 2007): 177–82. http://dx.doi.org/10.1002/ctpp.200710025.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Kudryavtsev, A. A., and L. D. Tsendin. "Townsend discharge instability on the right-hand branch of the Paschen curve." Technical Physics Letters 28, no. 12 (December 2002): 1036–39. http://dx.doi.org/10.1134/1.1535495.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Theis, Joseph G., Gregory R. Werner, Thomas G. Jenkins, and John R. Cary. "Computing the Paschen curve for argon with speed-limited particle-in-cell simulation." Physics of Plasmas 28, no. 6 (June 2021): 063513. http://dx.doi.org/10.1063/5.0051095.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Xu, Liang, Alexander V. Khrabrov, Igor D. Kaganovich, and Timothy J. Sommerer. "Investigation of the Paschen curve for helium in the 100–1000 kV range." Physics of Plasmas 24, no. 9 (September 2017): 093511. http://dx.doi.org/10.1063/1.5000387.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Ledernez, L., F. Olcaytug, and G. Urban. "Paschen Curve and Film Growth in Low Pressure Capacitively Coupled Magnetron Plasma Polymerization." Contributions to Plasma Physics 52, no. 4 (May 2012): 283–88. http://dx.doi.org/10.1002/ctpp.201100054.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Savic, Marija, Marija Radmilovic-Radjenovic, Milovan Suvakov, Srdjan Marjanovic, Dragana Maric, and Zoran Lj Petrovic. "On Explanation of the Double-Valued Paschen-Like Curve for RF Breakdown in Argon." IEEE Transactions on Plasma Science 39, no. 11 (November 2011): 2556–57. http://dx.doi.org/10.1109/tps.2011.2159244.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Hasan, Mazin H. "Electrical glow discharges and plasma parameter of planar sputtering system for silver target." Iraqi Journal of Physics (IJP) 16, no. 37 (September 11, 2018): 65–72. http://dx.doi.org/10.30723/ijp.v16i37.77.

Full text

Abstract:

DC planar sputtering system is characterized by varying discharge potential of (250-2000 volt) and Argon gas pressures of (3.5×10-2 – 1.5) mbar. The breakdown voltage for silver electrode was studied with a uniform electric field at different discharge distances, as well as plasma parameters. The breakdown voltage is a product of the Argon gas pressure inside the chamber and gab distance between the electrodes, represent as Paschen curve. The Current-voltage characteristics curves indicate that the electrical discharge plasma is working in the abnormal glow region. Plasma parameters were found from the current-voltage characteristics of a single probe positioned at the inter-cathode space. Typical values of the electron temperature and the electron density are in the range of (2.93 –5.3) eV and (10-16 -10-17) m-3 respectively.

APA, Harvard, Vancouver, ISO, and other styles

10

Scholfield, D. W., J. M. Gahl, and B. W. Mullins. "Investigation of the Paschen curve of nitrogen via the application of nanosecond pulsed electromagnetic radiation." Journal of Applied Physics 76, no. 3 (August 1994): 1469–75. http://dx.doi.org/10.1063/1.357721.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Kudryavtsev, A. A., and L. D. Tsendin. "Cathode boundary conditions for fluid model discharges on the right-hand branch of the Paschen curve." Technical Physics Letters 28, no. 8 (August 2002): 621–24. http://dx.doi.org/10.1134/1.1505530.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Gopikishan, S., I. Banerjee, K. A. Bogle, A. K. Das, A. P. Pathak, and S. K. Mahapatra. "Paschen curve approach to investigate electron density and deposition rate of Cu in magnetron sputtering system." Radiation Effects and Defects in Solids 171, no. 11-12 (December 2016): 999–1005. http://dx.doi.org/10.1080/10420150.2016.1267734.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Grishkov, A. A., Yu D. Korolev, and V. A. Shklyaev. "Monte-Carlo simulation of the ionization processes for discharges in the left branch of the Paschen curve." Journal of Physics: Conference Series 1393 (November 2019): 012007. http://dx.doi.org/10.1088/1742-6596/1393/1/012007.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Kozyrev, A. V., Yu D. Korolev, and N. S. Semeniuk. "Kinetic Model of Volume Discharge Formation on the Left Branch of a Paschen Curve with Cathode Initiation of a Breakdown." Bulletin of the Russian Academy of Sciences: Physics 83, no. 11 (November 2019): 1369–72. http://dx.doi.org/10.3103/s1062873819110157.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Hoshi, Y., and H. Yoshida. "Examination of laser-triggered discharge using a virtual gas model and the similarity of its Paschen curve with those of inert gases." Journal of Applied Physics 106, no. 6 (September 15, 2009): 066103. http://dx.doi.org/10.1063/1.3223536.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Huang, Bo Wun, Jung-Ge Tseng, Wen-Ye Huang, Neng-Hsin Chiu, and Zhi-Yin Huang. "The position effect on electrical field intensity for metal deposition process." Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 231, no. 2 (August 6, 2016): 355–58. http://dx.doi.org/10.1177/0954405415625917.

Full text

Abstract:

Material characteristics, such as electric potential, distance between target material and substrate, and so on, are important parameters for vacuum metal films deposition (sputtering) system. Properly controlling these parameters during the sputtering process can reduce the residual stress after deposition and can effectively improve the deformation of substrate and density of metal thin film. This study aims at simulating a vacuum metal film deposition system for substrate application with normal metal material. Both the copper foil, as a target material, and the substrate that is placed on a carrier platform are included in a vacuum chamber. The argon ion gas is excited by a radio frequency power generator to form the plasma source in the sputtering system. “Glow Discharge” of the “Paschen Curve” during plasma generation process is employed to excite the argon ion gas to bombard the target material. The ejected atoms of target material are deposited on the substrate surface to form the desired thin films. Several different parameters, such as radio frequency power, electric field intensity, distance between the target materials and the substrate, and so on, are discussed in this article. Numerical analysis results indicate that the distance between the substrate and target materials may affect the density of metal film significantly. The MATLAB simulation results can provide the technique of finding better workpiece height and high coating quality for the semi-conduction industrial adopting sputtering system for metal thin film production.

APA, Harvard, Vancouver, ISO, and other styles

17

Chodun, Rafal, Katarzyna Nowakowska-Langier, Krzysztof Zdunek, and Sebastian Okrasa. "The role of magnetic energy on plasma localization during the glow discharge under reduced pressure." Nukleonika 61, no. 2 (June 1, 2016): 191–94. http://dx.doi.org/10.1515/nuka-2016-0032.

Full text

Abstract:

Abstract In this work, we present the first results of our research on the synergy of fields, electric and magnetic, in the initiation and development of glow discharge under reduced pressure. In the two-electrode system under reduced pressure, the breakdown voltage characterizes a minimum energy input of the electric field to initiate and sustain the glow discharge. The glow discharge enhanced by the magnetic field applied just above the surface of the cathode influences the breakdown voltage decreasing its value. The idea of the experiment was to verify whether the contribution of potential energy of the magnetic field applied around the cathode is sufficiently effective to locate the plasma of glow discharge to the grounded cathode, which, in fact, is the part of a vacuum chamber wall (the anode is positively biased in this case). In our studies, we used the grounded magnetron unit with positively biased anode in order to achieve favorable conditions for the deposition of thin films on fibrous substrates such as fabrics for metallization, assuming that locally applied magnetic field can effectively locate plasma. The results of our studies (Paschen curve with the participation of the magnetic field) seem to confirm the validity of the research assumption. What is the most spectacular - the glow discharge was initiated between introduced into the chamber anode and the grounded cathode of magnetron ‘assisted’ by the magnetic field (discharge did not include the area of the anode, which is a part of the magnetron construction).

APA, Harvard, Vancouver, ISO, and other styles

18

Pyper, Diane M., and Saul J. Adelman. "Spectrophotometry of the Broad Continuum Features in Magnetic AP Stars." International Astronomical Union Colloquium 90 (1986): 201–4. http://dx.doi.org/10.1017/s0252921100091521.

Full text

Abstract:

The strongest broad absorption feature in the peculiar energy distributions of the Ap stars is that centered at about 5200 Å, thus the Stromgren y band and the Geneva VI band are most affected in stars in which this feature is strong. Fig. 1 shows bandpasses (full width at ½ intensity maximum) of three widely used photometric systems superimposed on two of our scans of Ap stars and two solar abundance line blanketed model atmospheres (Kurucz 1979). It is seen that both the y and VI bands fall entirely within the λ5200 feature. The plot (Fig. 2a) of b-y vs. Tpc (the color temperature of the red end of the Paschen continuum), shows that the b-y colors for most of our sample of Ap stars are displaced to the blue of the b-y, Teff relationship of Relyea and Kurucz (1978). In Fig. 2b, Δ(b−y) = (model b−y) − (observed b−y), for a given temperature is plotted vs. ΔWS2(5200), a spectrophotometric index measuring the equivalent width of the λ5200 feature. There is a strong correlation between Δ(b-y) and ΔWS2(5200), indicating quantitatively the large effect of the λ5200 feature on the y band, previously discussed by Adelman (1979). The deviations in Ap star B2-G values from the normal star B2-G vs. T curve are much less than for b-y, as the Geneva G band is largely outside the λ5200 feature (Fig. 2c). Thus B2-G is a better temperature indicator for Ap stars than is b-y (also see Hauck and North 1982).

APA, Harvard, Vancouver, ISO, and other styles

19

Levko, Dmitry, Robert R. Arslanbekov, and Vladimir I. Kolobov. "Modified Paschen curves for pulsed breakdown." Physics of Plasmas 26, no. 6 (June 2019): 064502. http://dx.doi.org/10.1063/1.5108732.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

McAllister, I. W. "Illusory Paschen curves associated with strongly electronegative gases." IEEE Transactions on Electrical Insulation 26, no. 3 (June 1991): 391–97. http://dx.doi.org/10.1109/14.85109.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Al-Hakary, Shamo Kh, Esraa A. Mohammed Saeed, Diyar A. Bleej, Suzan M. Haji, and Sahme A. Hussain. "Studing of Some Characteristics and parameters of Argon Glow discharge plasma Using Hollow Anode Diameter." Science Journal of University of Zakho 6, no. 1 (March 28, 2018): 26. http://dx.doi.org/10.25271/2018.6.1.401.

Full text

Abstract:

Hollow anode argon glow discharge plasma has been investigated experimentally at different argon gas pressure from constant discharge current. A sufficient high voltage has been applied among the electrodes to obtain breakdown. Firstly, we studied the influence of hollow anode diameter on the breakdown voltage and Paschens law. The inner diameters of hollow anodes used in our work were (10, 15, 20, 25, 30, 35, and 40) mm. Secondly under the same conditions we extended our study to measure some plasma parameters in the negative glow region using direct current argon glow discharge. The temperature and density of electrons in the negative glow were measured using double probes. From the (Ip-Vp) characteristics of double probes, we obtained plasma parameters by using computer MATLAB program. The results showed that the measured Pashence's curve closes to the well-known theoretical Pashence's law. The breakdown voltage and its minimum value decreased with increasing the hollow anode diameter. The Paschen’s curve became wide and shifted to lower pressure with increasing the diameter. The reduction area of hollow anode caused dens and luminous intensity of plasma to occur in the negative glow region. Increasing the diameter resulted in decreasing the temperature and density of electron.

APA, Harvard, Vancouver, ISO, and other styles

22

Karim, Pshtiwan M. A., Diyar S. Mayi, and Shamo Kh Al-Hakary. "Measurement of Some Argon Plasma Parameters Glow Discharge Under Axial Magnetic Field." Science Journal of University of Zakho 7, no. 4 (December 30, 2019): 158–66. http://dx.doi.org/10.25271/sjuoz.2019.7.4.628.

Full text

Abstract:

This paper investigates the characteristics some of argon plasma parameters of glow discharge under axial magnetic field. The DC power supply of range (0-6000) V is used as a breakdown voltage to obtain the discharge of argon gas. The discharge voltage-current (V-I) characteristic curves and Paschen’s curves as well as the electrical conductivity were studied with the presents of magnetic field confinement at different gas pressures. The magnetic field up to 25 mT was obtained using four coils of radius 6 cm and 320 turn by passing A.C current up to 5 Amperes. Spectroscopic measurements are employed for purpose of estimating two main plasma parameters electron temperature (Te) and electron density (ne). Emission spectra from positive column (PC) zone of the discharge have been studies at different values of magnetic field and pressures at constant discharge currents of 1.5 mA. Electron temperature (Te) and its density are calculated from the ratio of the intensity of two emission lines of the same lower energy levels. Experimental results show the abnormal glow region characteristics (positive resistance). Breakdown voltage versus pressure curves near the curves of paschen and decrease as magnetic field increases due to magnetic field confinement of plasma charged particles. Also the electrical conductivity increases due to enhancing magnetic field at different gas pressures. Both temperature density of electron and the intensities of two selected emission lines decrease with increasing pressure due decreasing of mean free path of electron. Electron density increase according to enhancing magnetic field, while the intensity of emitting lines tends to decrease.

APA, Harvard, Vancouver, ISO, and other styles

23

Mixon, P. D., S. T. Griffin, and J. C. Williams. "Breakdown Voltage Scaling Characteristics of an Argon Hollow Cathode Discharge." Applied Spectroscopy 47, no. 10 (October 1993): 1567–70. http://dx.doi.org/10.1366/0003702934334859.

Full text

Abstract:

Paschen curves are presented for hollow cathodes with diameters varying from 5 mm to 1.5 mm. The curves obey similar functions of ( pd), where p is the argon gas pressure and d is the hollow diameter. The curves exhibit similar properties in terms of the location of the breakdown voltage minima. The breakdown voltage increases monotonically for decreasing hollow diameter. The shapes of the various curves and the ( pd) minima location are unaffected by aspect ratio.

APA, Harvard, Vancouver, ISO, and other styles

24

Tirumala, Rakshit, and David B. Go. "An analytical formulation for the modified Paschen’s curve." Applied Physics Letters 97, no. 15 (October 11, 2010): 151502. http://dx.doi.org/10.1063/1.3497231.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Fu, Yangyang, Shuo Yang, Xiaobing Zou, Haiyun Luo, and Xinxin Wang. "Intersection of Paschen's curves for argon." Physics of Plasmas 23, no. 9 (September 2016): 093509. http://dx.doi.org/10.1063/1.4962673.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Fu, Yangyang, Peng Zhang, and John P. Verboncoeur. "Paschen's curve in microgaps with an electrode surface protrusion." Applied Physics Letters 113, no. 5 (July 30, 2018): 054102. http://dx.doi.org/10.1063/1.5045182.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Marić, D., N. Škoro, P. D. Maguire, C. M. O. Mahony, G. Malović, and Z. Lj Petrović. "On the possibility of long path breakdown affecting the Paschen curves for microdischarges." Plasma Sources Science and Technology 21, no. 3 (May 29, 2012): 035016. http://dx.doi.org/10.1088/0963-0252/21/3/035016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Manning, H. L. K., I. L. ten Kate, S. J. Battel, and P. R. Mahaffy. "Electric discharge in the Martian atmosphere, Paschen curves and implications for future missions." Advances in Space Research 46, no. 10 (November 2010): 1334–40. http://dx.doi.org/10.1016/j.asr.2010.07.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Khadayeir, Abdul hussain A., and Wessam M. Taher. "Effect of the Geometric of (Al) Hollow Cathode on Paschen Curves in Nitrogen." Journal of Physics: Conference Series 1234 (July 2019): 012018. http://dx.doi.org/10.1088/1742-6596/1234/1/012018.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Diab, F., W. H. Gaber, M. E. Abdel-kader, B. A. Soliman, and M. A. Abd Al-Halim. "Influence of cathode material type on the electrical breakdown behaviors of DC discharge." Canadian Journal of Physics 98, no. 8 (August 2020): 726–31. http://dx.doi.org/10.1139/cjp-2019-0547.

Full text

Abstract:

Paschen curves were studied using different cathode materials such as magnesium, zinc, and carbon graphite by discharge in argon gas of a pressure range between 0.08 and 3 Torr using a parallel plates configuration. The first and second Townsend coefficients (α and γ, respectively) and the ionization efficiency (η) of different cathode materials were deduced from Paschen curves as a function of the reduced field (E/P). The minimum breakdown voltage was found to be about 242 V for Mg material, which has the lowest work function, while carbon graphite has a higher breakdown voltage of 283 V due to its higher work function. The second coefficient γ was increased as a function of E/P and has higher values for materials of lower work functions, and a similar trend of γ is obtained as a function of the ion mean energy. On the other hand, the first coefficient α has a reverse behavior with both E/P and the work function of the cathode materials compared with the second coefficient. The ionization efficiency of the three cathode materials is identical, as η depends only on the gas properties and not the cathode material. η has a maximum value of about 0.025 V−1 for an E/P of about 185 Vcm−1Torr−1, corresponding to the maximum ionizing ability of electrons. The validation of the breakdown results has been confirmed by conferring with other published experimental measurements.

APA, Harvard, Vancouver, ISO, and other styles

31

Journal, Baghdad Science. "A Comparative Study on the Electrical Characteristics of Generating Plasma by Using Different Target Sources." Baghdad Science Journal 15, no. 4 (December 9, 2018): 436–40. http://dx.doi.org/10.21123/bsj.15.4.436-440.

Full text

Abstract:

In this research, the electrical characteristics of glow discharge plasma were studied. Glow discharge plasma generated in a home-made DC magnetron sputtering system, and a DC-power supply of high voltage as input to the discharge electrodes were both utilized. The distance between two electrodes is 4cm. The gas used to produce plasma is argon gas which flows inside the chamber at a rate of 40 sccm. The influence of work function for different target materials (gold, copper, and silver), - 5cm in diameter and around 1mm thickness - different working pressures, and different applied voltages on electrical characteristics (discharge current, discharge potential, and Paschen’s curve) were studied. The results showed that the discharge current and potential increase by increasing the applied voltage ranging between 300-700 V. Discharge current increased as working pressure increased in the beginning, and then semi-stabilized (slight increase) starting from 1×100 mbar, while discharge potential decreased at the beginning as working pressure increased and then semi-stabilized at the same point at which discharge current stabilized. The Paschen’s curves were compared with each other. It was concluded that the lower breakdown voltage was associated with lower work function of the (Au, Cu, and Ag) cathode material. Breakdown voltages were (395, 398, and 420) for Ag, Cu and Au respectively.

APA, Harvard, Vancouver, ISO, and other styles

32

Go, D. B., and A. Venkattraman. "Microscale gas breakdown: ion-enhanced field emission and the modified Paschen’s curve." Journal of Physics D: Applied Physics 47, no. 50 (November 28, 2014): 503001. http://dx.doi.org/10.1088/0022-3727/47/50/503001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Lester, J., J. M. Gahl, D. W. Scholfield, and N. Shimomura. "Investigation of intense electromagnetic transient phenomenon and Paschen curves for hydrogen and helium in subnanosecond regime." IEEE Transactions on Plasma Science 28, no. 3 (June 2000): 496–501. http://dx.doi.org/10.1109/27.887657.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Lyu, Xingbao, Chengxun Yuan, Svetlana Avtaeva, Anatoly Kudryavtsev, Jingfeng Yao, Zhongxiang Zhou, and Xiaoou Wang. "Paschen curves and current–voltage characteristics of large-area short glow discharge with different electrode structures." Physics of Plasmas 27, no. 12 (December 2020): 123509. http://dx.doi.org/10.1063/5.0027931.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Go, David B., and Daniel A. Pohlman. "A mathematical model of the modified Paschen’s curve for breakdown in microscale gaps." Journal of Applied Physics 107, no. 10 (May 15, 2010): 103303. http://dx.doi.org/10.1063/1.3380855.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Chen, Jiandong, John P. Verboncoeur, and Yangyang Fu. "Microgap breakdown with floating metal rod perturbations." Applied Physics Letters 121, no. 7 (August 15, 2022): 074102. http://dx.doi.org/10.1063/5.0104205.

Full text

Abstract:

We report the characterization of microgap breakdown with perturbations from a metal rod floating between anode and cathode electrodes. The effects of the metal rod on the electric field distribution and the field enhancement factor are evaluated by numerical simulation and the conformal mapping method, and they indicate that the field emission regime is not reached. The breakdown voltages in the Townsend discharge regime are determined based on the voltage–current characteristics, which are obtained from two-dimensional fluid simulations. It is found that the breakdown characteristics can be significantly modulated by the floating metal rod, and the breakdown curve (breakdown voltage vs the net gap distance) is no longer U-shaped, which deviates from the conventional Paschen's law. The underlying physical mechanisms are related to the electric field enhancement, curved breakdown path, and nonuniform ion flux caused by the electric shielding effect. The results provide insights into breakdown characteristics in microscale discharges, which may promote conventional investigation of simplified clean gaps toward more complex conditions (e.g., with floating microparticles) in miniaturized plasma devices.

APA, Harvard, Vancouver, ISO, and other styles

37

Shager, Azza M., Amany T. Sroor, Hoda A. El Tayeb, Hoda A. El Gamal, and Mohamed M. Masoud. "Nitrogen Glow Discharge by a DC Virtual Cathode." Zeitschrift für Naturforschung A 63, no. 7-8 (August 1, 2008): 412–18. http://dx.doi.org/10.1515/zna-2008-7-805.

Full text

Abstract:

A DC glow discharge operating with a virtual cathode is studied. The system consists of a solid disc cathode and mesh anode. The discharge occurs in nitrogen gas at the left-hand side of Paschen’s curve. The plasma electron density in the axial direction has been found to be 0.2 · 108 cm−3 at 2 cm from the mesh. The electron temperature peak value has been found to be 3.5 eV at 6 cm from the mesh. The radial distribution of the plasma electron density and temperature are discussed. The variation of the plasma parameters are in good agreement with the experimental results.

APA, Harvard, Vancouver, ISO, and other styles

38

Abdel Rahman, M. M., F. W. Abdel Salam, and B. A. Soliman. "Improved treatment of home-made glow discharge ion source." Journal of Physics: Conference Series 2304, no. 1 (August 1, 2022): 012011. http://dx.doi.org/10.1088/1742-6596/2304/1/012011.

Full text

Abstract:

Abstract For a better treatment, a new class of DC ion source (DCIS) was developed and adapted to provide low-power, highly-density plasma and ion-current applications. Such an ion source operates under the mode of abnormal glow discharge being of the self-extraction category, with specific features such as simple operation, stable discharge, and the ability to use for a variety of plasma, ion, and electron beam applications. A teflon disc with different diameters has been installed in between the two electrodes. This disc covered the cathode area, reducing the discharge area on the cathode surface for discharge confinement, and thus allowing for a higher output ion beam current. Pressures of 10−4 mbar, a 3 mm gap between the electrodes, and a 5 mm teflon diameter were observed to be the optimal operating conditions. At this ideal distance, hydrogen, nitrogen, and argon gases were used to investigate internal and external operational parameters. Finally, the Paschen curves were determined for hydrogen, air, as well as nitrogen gases.

APA, Harvard, Vancouver, ISO, and other styles

39

Kim, June Young, Igor Kaganovich, and Hyo-Chang Lee. "Review of the gas breakdown physics and nanomaterial-based ionization gas sensors and their applications." Plasma Sources Science and Technology 31, no. 3 (March 1, 2022): 033001. http://dx.doi.org/10.1088/1361-6595/ac4574.

Full text

Abstract:

Abstract Ionization gas sensors are ubiquitous tools that can monitor desired gases or detect abnormalities in real time to protect the environment of living organisms or to maintain clean and/or safe environment in industries. The sensors’ working principle is based on the fingerprinting of the breakdown voltage of one or more target gases using nanostructured materials. Fundamentally, nanomaterial-based ionization-gas sensors operate within a large framework of gas breakdown physics; signifying that an overall understanding of the gas breakdown mechanism is a crucial factor in the technological development of ionization gas sensors. Moreover, many studies have revealed that physical properties of nanomaterials play decisive roles in the gas breakdown physics and the performance of plasma-based gas sensors. Based on this insight, this review provides a comprehensive description of the foundation of both the gas breakdown physics and the nanomaterial-based ionization-gas-sensor technology, as well as introduces research trends on nanomaterial-based ionization gas sensors. The gas breakdown is reviewed, including the classical Townsend discharge theory and modified Paschen curves; and nanomaterial-based-electrodes proposed to improve the performance of ionization gas sensors are introduced. The secondary electron emission at the electrode surface is the key plasma–surface process that affects the performance of ionization gas sensors. Finally, we present our perspectives on possible future directions.

APA, Harvard, Vancouver, ISO, and other styles

40

Femi, R., Shibu Clement, Anita Agrawal, and A. Amalin Prince. "Investigation of Microelectromechanical Switches for Next Generation DC Power Distribution System." International Journal of Emerging Electric Power Systems 15, no. 6 (December 1, 2014): 591–605. http://dx.doi.org/10.1515/ijeeps-2014-0042.

Full text

Abstract:

Abstract This paper investigates the application of microelectromechanical system (MEMS) switches for DC power distribution system. Traditional electromechanical switches, solid state switches and solid state switch array are studied and simulated to understand their characteristics. Performance and characteristics of MEMS switches are reviewed and identified that electrostatically actuated MEMS switches are suitable for DC power applications. Scalable total cross tied (TCT) array configuration using MEMS switches has been proposed. The proposed configuration is suitable for variable voltage/current rating. Arc-less behavior of the switch configuration is analyzed using modified Paschen’s curve. 400 V/6 A system is considered for the simulation and comparative study. The simulated result of the proposed MEMS switch array configuration is compared with the traditional switches. The comparative study shows that the proposed switch array configuration gives better performance in terms of voltage drop, leakage current, power loss, arc and size. This can be used in DC power system protection, circuit breaking, battery protection and smart grid load switching applications.

APA, Harvard, Vancouver, ISO, and other styles

41

Legalov, Andrei A. "Four new species of the genera Dryophthoroides Roelofs, 1879 and Nephius Pascoe, 1885 (Coleoptera, Curculionidae) from Oriental and Papuan Regions." Ecologica Montenegrina 58 (October 26, 2022): 42–49. http://dx.doi.org/10.37828/em.2022.58.4.

Full text

Abstract:

Four new species of the genera Dryophthoroides Roelofs, 1879 and Nephius Pascoe, 1885 from the tribe Stromboscerini of the subfamily Dryophthorinae are described and illustrated. Dryophthoroides telnovi Legalov, sp. nov. from New Guinea (Star Mountains) is similar to D. seftoni (Zimmermann, 1944) bit differs in the shorter and thicker rostrum and narrower pronotum. It is distinguish from D. beccarii (Pascoe, 1885) in the smaller body size, thicker rostrum, coarser punctured pronotum, not subparallel elytra and narrower elytral interstriae. Dryophthoroides insularis Legalov, sp. nov. from North Moluccas (Bacan Islands) differs from D. telnovi Legalov, sp. nov. in the wider, laterally weakly rounded pronotum with a more finely punctured pronotal disc, the stronger widened interstria five at apex, the smaller punctures in elytral striae, the wider elytral interstriae and the longer and thinner rostrum. Nephius continentalis Legalov, sp. nov. from Laos (Hua Phan Prov.) differs from N. kalimantanensis Legalov, 2022 in the thicker and shorter rostrum, the pronotum lacking the sharp preapical constriction, the elytra with the greatest width postmedium, the medially not depressed lateral sides of the pronotum, and the obsolete humeri. Nephius philippinensis Legalov, sp. nov. from the Philippines (Mindanao Is., Bukidnon Prov.) differs from N. mindanaoensis Legalov, 2020 in the sparsely punctate pronotum with a median longitudinal groove and lacking four premedian pilose ridges, the elytral interstriae with weak pilose ridges, and the less curved rostrum.

APA, Harvard, Vancouver, ISO, and other styles

42

SHEMSHADI, A., and S. JALALI KASHANI. "THE REQUISITION OF AUTO SYNCHRONISM FOR VACUUM INTERRUPTERS DURING QUENCHING ARC INTERVAL." Latin American Applied Research - An international journal 48, no. 1 (January 31, 2019): 1–5. http://dx.doi.org/10.52292/j.laar.2018.249.

Full text

Abstract:

This investigation presents new practical-based achievements for velocity of dielectric recovery process lead to successful quenching arc inside a vacuum interrupter (VI) chamber related to arcing interval duration with utilization of thermionic emission theory. A high voltage impulse is applied to the contacts of a vacuum interrupter to cause insulation failure during quenching arc interval with utilization of new high-speed spark gap switch concerning 4 mm contact distance. Regarding to left branch of paschen's curve the achieved results are admissible. But for some data with equal H.V. pulse time, it was observed that the breakdown voltage level, for similar quenching time, may differ regarding to arcing time duration. Longer the arcing time results stiffer insulation recovery process. In addition, more arcing time results to more corrosion in contacts. These truths demonstrate the requisition of designing a synchronous observer system to control the moment of mechanical opening process regarding to quenching sinusoidal current waveform. This system should continuously analyze and predict the next zero-crossing of the current waveform to trigger the mechanical opening mechanism after last peak of the flowing current.

APA, Harvard, Vancouver, ISO, and other styles

43

Asghar, Atif H., and Ahmed Rida Galaly. "The Influence of Different Plasma Cell Discharges on the Performance Quality of Surgical Gown Samples." Materials 14, no. 15 (August 3, 2021): 4329. http://dx.doi.org/10.3390/ma14154329.

Full text

Abstract:

An experimental study was performed on a low-density plasma discharge using two different configurations of the plasma cell cathode, namely, the one mesh system electrodes (OMSE) and the one mesh and three system electrodes (OMTSE), to determine the electrical characteristics of the plasma such as current–voltage characteristics, breakdown voltage (VB), Paschen curves, current density (J), cathode fall thickness (dc), and electron density of the treated sample. The influence of the electrical characteristics of the plasma fluid in the cathode fall region for different cathode configuration cells (OMSE and OMTSE) on the performance quality of a surgical gown was studied to determine surface modification, treatment efficiency, exposure time, wettability property, and mechanical properties. Over a very short exposure time, the treatment efficiency for the surgical gown surface of plasma over the mesh cathode at a distance equivalent to the cathode fall distance dc values of the OMTSE and for OMSE reached a maximum. The wettability property decreased from 90 to 40% for OMTSE over a 180 s exposure time and decreased from 90 to 10% for OMSE over a 160 s exposure time. The mechanisms of each stage of surgical gown treatment by plasma are described. In this study, the mechanical properties of the untreated and treated surgical gown samples such as the tensile strength and elongation percentage, ultimate tensile strength, yield strength, strain hardening, resilience, toughness, and fracture (breaking) point were studied. Plasma had a more positive effect on the mechanical properties of the OMSE reactor than those of the OMTSE reactor.

APA, Harvard, Vancouver, ISO, and other styles

44

Morris, M. R., J. H. Zhao, and W. M. Goss. "Nonthermal filamentary radio features within 20 pc of the Galactic center." Proceedings of the International Astronomical Union 9, S303 (October 2013): 369–73. http://dx.doi.org/10.1017/s1743921314000933.

Full text

Abstract:

AbstractDeep imaging of the Sgr A complex at 6 cm wavelength with the B and C configurations of the Karl G. Jansky VLA† has revealed a new population of faint radio filaments. Like their brighter counterparts that have been observed throughout the Galactic center on larger scales, these filaments can extend up to ∼10 parsecs, and in most cases are strikingly uniform in brightness and curvature. Comparison with a survey of Paschen-α emission reveals that some of the filaments are emitting thermally, but most of these structures are nonthermal: local magnetic flux tubes illuminated by synchrotron emission. The new image reveals considerable filamentary substructure in previously known nonthermal filaments (NTFs). Unlike NTFs previously observed on larger scales, which tend to show a predominant orientation roughly perpendicular to the Galactic plane, the NTFs in the vicinity of the Sgr A complex are relatively randomly oriented. Two well-known radio sources to the south of Sgr A – sources E and F – consist of numerous quasi-parallel filaments that now appear to be particularly bright portions of a much larger, strongly curved, continuous, nonthermal radio structure that we refer to as the “Southern Curl”. It is therefore unlikely that sources E and F are Hii regions or pulsar wind nebulae. The Southern Curl has a smaller counterpart on the opposite side of the Galactic center – the Northern Curl – that, except for its smaller scale and smaller distance from the center, is roughly point-reflection symmetric with respect to the Southern Curl. The curl features indicate that some field lines are strongly distorted, presumably by mass flows. The point symmetry about the center then suggests that the flows originate near the center and are somewhat collimated.

APA, Harvard, Vancouver, ISO, and other styles

45

Yamamoto, Roberto K., Mário R. Gongora-Rubio, Rodrigo S. Pessoa, Márcio R. Cunha, and Homero S. Maciel. "Mixed LTCC and LTTT Technology for Microplasma Generator Fabrication." Journal of Microelectronics and Electronic Packaging 6, no. 2 (April 1, 2009): 101–7. http://dx.doi.org/10.4071/1551-4897-6.2.101.

Full text

Abstract:

An issue of paramount importance for the fabrication of microplasma devices is internal structure flatness. To overcome this problem we devised a fabrication method using LTCC (Low Temperature Cofired Ceramic) and LTTT (Low Temperature Transfer Tape) technologies. The flexibility resulting from mixing these technologies could enable fabrication of certain microfluidic applications. In the present work, the fabrication of a microplasma generator using a mixed LTCC and LTTT technology is presented. Silver-palladium electrodes were screen printed on the green tapes and were cofired after machining of microchannels and other structures. Two electrode plates were obtained separately in this way using a setter powder sheet to ensure flatness. In the postfire process, transfer tapes were used to bind the two electrode plates and the electrode spacer together to make the final device structure. Uniform and stable glow discharges were obtained in argon, nitrogen, oxygen, and sulfur hexafluoride gases. Paschen's curves, V-I characteristics, and optical emission spectra were obtained in DC discharges. The fabrication method presented has been demonstrated to be very reproducible and produced very flat electrodes.

APA, Harvard, Vancouver, ISO, and other styles

46

Gupta, Anshuma, and Sudha Singh. "A Conceptual and Applied Study of Trividha Karmain Shalyatantra." International Research Journal of Ayurveda & Yoga 05, no. 04 (2022): 133–37. http://dx.doi.org/10.47223/irjay.2022.5420.

Full text

Abstract:

All types of Ayurvedictreatments are described under Ashtang Ayurvedawhich means eight branches of Ayurveda. Shalya tantrais one of them and Sushruta Samhitais the oldest text available on Shalya Tantra(surgery).The Sushruta Samhita acts as a training manual and educativetext for surgery, and enabled a move away from the more primitive forms of surgery practiced beforehand. Many procedures and methods of surgery were described and in some way acts as a basic manual from which surgery in the modern day has grown from.SutraSthanaof Sushruta Samhitadeals with basic concepts of surgery, surgical instruments and appliances, practical training, duties of the surgeon, Sandhan Karma,causes and classification of diseases etc.Being a surgeon Acharya Sushrutawas well aware aboutthe complications of surgery so before talking anything about the surgery first he told about the concept of Trividh Karmai.e. poorva karmameans accessories to be obtained before the commencement of main surgical procedure, pradhan karmameans main surgical procedure, paschat karmameans measures that should be taken to cure the patient after main surgical procedure until the patient is discharged.

APA, Harvard, Vancouver, ISO, and other styles

47

Mukherjee, Anupam, Ayushman Banerjee, and Kaushik D. Das. "Homoeopathic Awareness among the Tribal Population Visiting a Homoeopathic Hospital set up in West Bengal." Homœopathic Links 32, no. 02 (June 2019): 077–81. http://dx.doi.org/10.1055/s-0039-1693112.

Full text

Abstract:

Background Tribal population in India had been known to depend on traditional tribal medicines for long to cure their ailments. With the development of health care facilities and spread of AYUSH system:of late many tribal people are seeking homoeopathic treatment. More than half of the tribal population of West Bengal are concentrated in the South western part of the state that covers the districts of Paschim Medinipur, Purulia, and Bankura. Midnapore Homoeopathic Medical College and Hospital being located in the same region gets a good number of tribal patients seeking homoeopathic care. Objective To assess the level of homoeopathic awareness and the reasons for their preference to homoeopathic system. Methods A cross sectional survey was conducted in the outpatient department of Midnapore Homeopathic Medical College and Hospital, Government of West Bengal, India from January 2016 to June 2016 on adult tribal population using a self-administered questionnaire. Results The survey performed on tribal patients reflected the level of homoeopathic awareness, prevalence of disease, socio-demographic data, and health status of the tribal population. The positive effect with homoeopathic treatment also became evident in the study. Conclusion A favorable attitude toward homoeopathy among the tribal population was obtained. However, some wrong notions about the mode also emerged in the study. In this respect, the authors felt the need on arrangement of homoeopathic health camps and distribution of homoeopathic awareness materials in tribal language to improve the scenario.

APA, Harvard, Vancouver, ISO, and other styles

48

Díaz, A. I., G. F. Hägele, M. V. Cardaci, E. Terlevich, and R. Terlevich. "Kinematics of the Circumnuclear Region of NGC 3351." Proceedings of the International Astronomical Union 2, S235 (August 2006): 308. http://dx.doi.org/10.1017/s1743921306006739.

Full text

Abstract:

AbstractUsing high-resolution blue and far red spectra from the William Herschel Telescope, we have mapped the velocity field along three different slits in the central kiloparsec of the spiral galaxy NGC 3351. We have measured ionized gas (Hβ and [Oiii]) and stellar (near-IR Ca triplet) velocity dispersions for five individual Circumnuclear Star Forming Regions (CNSFRs) and the nucleus. Velocities and velocity dispersions in the red range were obtained using the cross-correlation technique of Tonry & Davis (1979AJ.84.1511) with a set of eleven templates, following the work by Nelson & Whittle (1995.ApJSS.99.67) with the variations introduced by Palacios et al. (1997.A & A.323.749). The gas velocities and velocity dispersions have been measured by fitting gaussians to the emission lines (Hβ and [OIII] λ5007Å) using three different suitable continua chosen by visual inspection and taking the average of the three results (Jiménez-Benito et al., 2000.MNRAS.317.907).The rotation velocities derived for gas and stars are in very good agreement, although in some cases the gas seems to rotate slightly faster than stars. The turnover points of the rotational curves seem to be located at the same position than the star forming ring as found in other galaxies (Díaz, R. et al., 1999ApJ.512.623). The derived values are consistent with those previously obtained for the systemic velocity of NGC 3351 (Planesas et al., 1997.A & A.325.81).The velocity dispersions of the stars are always larger (by between 10 and 25 km/sec) than those derived from Hβ emission lines. In the cases in which it has been possible to use the Paschen emission lines, the results obtained are similar. The twice ionized oxygen, on the other hand, shows velocity dispersions comparable to the stellar ones or, in some cases, even larger. It is however important to point out that in these metal rich regions the [Oiii] lines are very weak and they have a poor signal to noise ratio, then it is more difficult to accurately estimate the global kinematic behaviour from this emission line.The difference between the behavior of ionized hydrogen and stars could be interpreted by assuming that the gas is confined to the disc and supported by rotation while the stars are mostly supported by dynamical pressure (see Pizzella et al., 2004.A & A.424.447). However, the kinematics of ionized gas as mapped by [Oiii], as we mentioned above, is similar to that of the stellar component.We have applied the virial theorem to estimate the dynamical masses of the clusters and the galactic nucleus, assuming that the systems are gravitationally bound and spherically symmetric, and using sizes measured from the HST-WFPC2 image in the F606W filter (sizes between 2.6 and 5.1 pc). These values of the masses, estimated from stellar velocity dispersion measurements as mapped by the CaT lines, are in the range between 5.1×106 and 5.0×107 M⊙ for the five studied CNSFRs and 3.6×107 M⊙ for the nucleus of the galaxy, in the inner 23.4 pc.

APA, Harvard, Vancouver, ISO, and other styles

49

Han, W., X. Wang, L. LI, S. Wichuk, E. Hutchings, R. Dadashova, J. Paschke, and W. P. Maksymowych. "OP0304 METABOLOMICS PROFILING OF HUMAN SERUM FOR DISCOVERING BIOMARKERS TO DIAGNOSE PSORIATIC ARTHRITIS AND ANKYLOSING SPONDYLITIS WITH HIGH SPECIFICITY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 188.2–189. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5912.

Full text

Abstract:

Background:High-specificity biomarkers that can differentiate PsA and AS patients from healthy people, as well as RA patients, would be extremely helpful for early diagnosis and treatment of these two diseases. Based on the hypothesis that each disease state may cause specific changes to the metabolome, metabolomics is becoming a powerful tool for biomarker discovery. In this work, we applied a high-performance chemical isotope labeling (CIL) LC-MS platform to search for biomarker candidates of PsA and AS in human serum samples.Objectives:We aimed to identify metabolite biomarkers with high specificity for PsA and AS.Methods:Serum samples were collected from 331 subjects, including 100 healthy controls, 48 PsA patients, 52 AS patients and 131 RA patients. The average age of each group was: 52.6 (control), 50.7 (PsA), 51.8 (AS) and 53.1 (RA) years. After pre-treatment, each sample was incubated with12C-dansyl chloride, which can label the amine/phenol-containing metabolites. The reference sample for relative quantification was prepared by mixing all individual samples and then labeled by13C-dansyl chloride. With this normalization, the individual samples and the reference sample were mixed at an equal amount. Finally, we used an LC-QTOF-MS platform to analyze the mixtures and measure the12C/13C peak pairs.Results:We detected 1,149 peak pairs commonly existing in the serum samples. Using our dansyl-library of 700 dansyl-labeled standards and a prediction library, which contains the predicted retention times and mass values of 3,431 dansylated human metabolites, we identified 134 and 141 peak pairs, respectively. The relative concentrations are calculated from the intensity ratios of12C/13C peak pairs. We first visualized the entire amine/phenol-submetabolome for all phenotypes using the partial least squares discriminant analysis (PLS-DA). We found that the most significant between-group separation was between healthy controls and all the patients. No significant sex or age effect was observed. Furthermore, among the three diseases, PsA and AS samples were closely clustering, while the RA group was well separated from them. Therefore, we chose a two-step diagnosis approach that first differentiates PsA patients from controls/RA patients and then filters out the AS patients wrongly classified as PsA in the first step. The same strategy was conducted for AS. Stipulating a fold change larger than 1.5 with the false discovery rate lower than 5%, we found 74 metabolites having significantly higher or lower concentrations in the PsA group compared to the control or the RA group. We selected two of these significant metabolites to build a classification model based on the linear support vector machine (SVM) method, and the area-under-the-curve (AUC) value of the resulting receiver operating characteristic (ROC) curve was 0.929 (95% confidence interval: 0.899-0.956). Similarly, 37 metabolites could differentiate AS samples from RAs and controls. A proposed diagnostic panel containing four metabolites demonstrated an AUC value of 0.890 (0.843-0.934). For the last step, distinguishing between PsA and AS, there were 15 significantly increased metabolites and 9 lowered ones. The biomarker panel consisting of the top three metabolites also achieved good discriminatory power with AUC = 0.827 (0.717-0.919).Conclusion:Isotope-labeling-LC-MS-based metabolomics has revealed biomarker candidates that can specifically differentiate PsA or AS patients from control populations.Disclosure of Interests:Wei Han: None declared, Xiaohang Wang: None declared, Liang Li: None declared, Stephanie Wichuk: None declared, Edna Hutchings: None declared, Rana Dadashova: None declared, Joel Paschke: None declared, Walter P Maksymowych Grant/research support from: Received research and/or educational grants from Abbvie, Novartis, Pfizer, UCB, Consultant of: WPM is Chief Medical Officer of CARE Arthritis Limited, has received consultant/participated in advisory boards for Abbvie, Boehringer, Celgene, Eli-Lilly, Galapagos, Gilead, Janssen, Novartis, Pfizer, UCB, Speakers bureau: Received speaker fees from Abbvie, Janssen, Novartis, Pfizer, UCB.

APA, Harvard, Vancouver, ISO, and other styles

50

Bradley, John S., Nataliia Makieieva, Camilla Tøndel, Emmanuel Roilides, Matthew S. Kelly, Munjal Patel, Pavan Vaddady, et al. "1159. Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Pediatric Participants With Confirmed or Suspected Gram-negative Bacterial Infections: A Phase 1b, Open-label, Single-Dose Clinical Trial." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S671. http://dx.doi.org/10.1093/ofid/ofab466.1352.

Full text

Abstract:

Abstract Background Imipenem/cilastatin/relebactam (IMI/REL) is approved for treating hospital-acquired/ventilator-associated bacterial pneumonia, complicated urinary tract infection, and complicated intra-abdominal infection in adults. This study assessed single-dose pharmacokinetics (PK), safety, and tolerability of IMI/REL in neonatal and pediatric participants with confirmed or suspected gram-negative bacterial infections. Methods This was a phase 1, open-label, non-comparative study (NCT03230916). Age- and weight-adjusted dosing is summarized in Table 1. The primary objective was to characterize the PK profiles for imipenem and relebactam after a single intravenous dose of IMI/REL. PK parameters were analyzed using population modeling. The PK target for imipenem was the percent time of the dosing interval that the unbound plasma concentration exceeded the minimum inhibitory concentration (%fT >MIC) of ≥30% (MIC used, 2 µg/mL). The PK target for relebactam was an area under the curve (AUC)/MIC ratio >8 (MIC used, 2 µg/mL), corresponding to AUC0-24h >58.88 μM∙h. Safety and tolerability were assessed for up to 14 days after drug infusion. Results Of the 46 participants who received IMI/REL, 42 were included in the PK analysis. The mean plasma concentration-time profiles for imipenem and relebactam were generally comparable across age cohorts (Figure). For imipenem, the geometric mean %ƒT >MIC ranged from 50% to 94% and the mean maximum concentration (Cmax) ranged from 65 μM to 126 μM (Table 2). For relebactam, the geometric Cmax ranged from 33 μM to 87 μM and mean AUC0-6h ranged from 51 μM·h to 159 μM·h across the age cohorts (Table 2). IMI/REL was well tolerated with 8 (17.4%) participants experiencing ≥1 adverse events (AE) and 2 (4.3%) participants experiencing AE that were deemed drug related by the investigator. Drug-related AE were increased alanine aminotransferase, increased aspartate aminotransferase, anemia, and diarrhea, which were non-serious, mild in severity, and resolved within the follow-up period of 14 days. Figure 1 Conclusion Imipenem and relebactam exceeded the pediatric plasma PK targets across pediatric age cohorts in the study; the single doses of IMI/REL were well tolerated. These results will inform IMI/REL dose selection for further pediatric clinical evaluation. Disclosures Camilla Tøndel, MD, PhD, Merck & Co., Inc., (Grant/Research Support) Emmanuel Roilides, MD, PhD, FIDSA, FAAM, FESCMID, FECMM, FISAC, Merck Sharp & Dohme Corp. (Consultant, Grant/Research Support) Matthew S. Kelly, MD, MPH, Merck Sharp & Dohme Corp. (Consultant, Grant/Research Support) Munjal Patel, PhD, Merck Sharp & Dohme Corp. (Employee, Shareholder) Pavan Vaddady, PhD, Merck Sharp & Dohme Corp. (Employee) Alok Maniar, MD, MPH, Merck Sharp & Dohme Corp. (Employee, Shareholder) Ying Zhang, PhD, Merck & Co., Inc. (Employee, Shareholder) Amanda Paschke, MD MSCE, Merck Sharp & Dohme Corp. (Employee, Shareholder) Joan R. Butterton, MD, Merck Sharp & Dohme Corp. (Employee, Shareholder) Luke F. Chen, MBBS MPH MBA FRACP FSHEA FIDSA, Merck (Employee)

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!