Dissertations / Theses on the topic 'Partners of cancer patients'
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Marshall, Catherine. "Breast reconstruction following cancer : its impact on patients' and partners' sexual functioning." Thesis, Lancaster University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421845.
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Nijboer, Christine. "Caregiving to patients with colorectal cancer a longitudinal study on caregiving by partners /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/81019.
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Blakely, Hannah Virginia Caroline. "Psychological Distress and Relationship Satisfaction in Cancer Patients and the Impact of Partners." Thesis, University of Canterbury. Psychology, 2010. http://hdl.handle.net/10092/5290.
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This study examines psychological distress and relationship satisfaction in cancer patients and their partners. It is widely recognized that spouses coping with a cancer diagnosis are at risk of psychological distress, and changes in relationship satisfaction. Debate exists within the literature regarding the level of distress and satisfaction experienced by patients, and to what extent they are influenced by their partners. Twenty six couples coping with a breast or prostate cancer diagnosis, completed two questionnaires over six months assessing: psychological distress, relationship satisfaction, attachment style, self -esteem and matching of partner ideal standards. The cross-sectional results indicate that higher patient distress was associated with their own lower levels of self esteem, less secure, and more anxious attachment styles. Patient relationship satisfaction was increased in those with a less anxious attachment style and in patients who perceived their partner as matching more closely their own ideal standards and perceptions of the patients on vitality and attractiveness.
Longitudinal results show an increase in patient distress was also predicted by their partner’s perceiving lower matching between their own ideal standards and perceptions of the patients on warmth and trustworthiness. Unexpectedly, higher relationship satisfaction over time, was also predicted by lower matching of their own ideal standards and perceptions of their partners on warmth and trustworthiness, as measured initially. An increase in patient satisfaction was also predicted over time when patient distress was low, self esteem high and they had higher matching between their own ideal standards and partner perceptions of the patient partner on both warmth and trustworthiness as well as vitality and attractiveness. Explanations for the results, together with clinical and research implications are discussed.
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Pikler, Vanessa I. Brown Chrisanthia. "The influence of gender role socialization on cancer patients' and partners' psychological distress and quality of life." Diss., UMK access, 2006.
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Thesis (Ph. D.)--School of Education. University of Missouri--Kansas City, 2006."A dissertation in counseling psychology." Advisor: Chrisanthia Brown. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 13, 2007. Includes bibliographical references (leaves 94-103). Online version of the print edition.
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Wanat, Marta. "Experiences of patients and of partners of patients with a recurrence of colorectal cancer : a qualitative longitudinal study." Thesis, Oxford Brookes University, 2015. https://radar.brookes.ac.uk/radar/items/9912e10c-df4d-4a31-b87e-7fddc97f4017/1/.
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Colorectal cancer is the fourth most common cancer type in the UK. Following treatment, many patients will recover and be considered cured. However, this is not the case for all patients and some will face a recurrence of their cancer. This PhD aimed to explore the experiences of patients and partners of patients when colorectal cancer recurs. A meta-ethnography and literature review were conducted to examine the existing research evidence on the experiences of patients and of partners, respectively, at the time of recurrence. While these reviews provided some insights, they also highlighted the lack of studies exploring this important phase in the cancer journey. Interpretative Phenomenological Analysis (IPA) was chosen as a methodology to explore in depth the experiences of patients and partners. A longitudinal design was used to capture changes in participants’ experiences. Analysis of interviews with six patients with colorectal cancer recurrence and five partners revealed that the initial diagnosis was an important framework for making sense of the diagnosis of recurrence. Specifically, participants compared the treatment options, quality of care and prognosis at the time of recurrence to those at initial diagnosis which, in turn, could either magnify or lessen their distress. Patients faced challenges in sharing their experience, including their emotions and information on their illness. Partners also struggled to share their experiences with other people, but these challenges were mainly related to the physical and emotional burden of caring. Finally, the study also highlighted that the diagnosis of recurrence disrupted previous rhythms of life for both patients and partners. While patients’ accounts focused on ways of negotiating the place of cancer in their lives within the context of coping with physical suffering, partners also grieved the loss of a previous relationship with a patient. This PhD captures the difficult experience of colorectal cancer recurrence for patients and partners, and the complex psychological processes that underpin this experience. The findings have clinical implications regarding information and supportive care provision and may help to inform further development of health care services for patients with colorectal cancer recurrence and their partners.
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Ash, Kristen M. "Language Style Matching as a Predictor of Successful Coping in Breast Cancer Patients and Their Partners." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/243736.
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Past research has shown that the use of function words--such as pronouns--in Language Style Matching accurately predicts relationship satisfaction and success. The current study on breast cancer patients focuses on two main hypotheses. First, we predicted that LSM would correlate positively with relationship satisfaction and this correlation would be unique to the patient-partner relationship. Second, it follows that LSM would positively correlate with successful use of coping mechanisms for breast cancer patients and their partners. We operationalized coping through two questionnaires, the dyadic adjustment scale (DAS) and the center for epidemiological studies depression scale (CES-D), assessed longitudinally. The linguistic inquiry word count program (LIWC) software measured LSM by counting function words obtained by the objective sound clips recorded by an electronically activated recorder (EAR). Cancer patients and their partners exhibited high LSM and overall variance was low (.001) within couples (.002) and between friends and family (.061). Personal pronouns correlate with overall satisfaction as reported by partners. Conversely, LSM within couples did not predict depression in partners or patients. Results suggest that in the matter of cancer patients and their partners’ self reported adjustment LSM does not significantly matter.
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Mohd, Naim Noor Faizah. "Armus dual roles in autophagy and E-cadherin degradation : distinct partners, regulation and implications for cancer patients." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/47979.
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Cancer is one of the leading causes of mortality worldwide. Invasion, metastasis and apoptotic evasion are cancer hallmarks. Tumour cell metastasis requires loss of E-cadherin cell-cell adhesion receptor. Apoptotic evasion can be mediated by up-regulation of autophagy, which maintains cellular energy during metabolic stress in cancer cells. Armus is a TBC/RabGAP protein that regulates both E-cadherin degradation and autophagy by controlling lysosome fusion with late vesicular compartments or autophagosomes. Understanding Armus function in these degradative processes during tumourigenesis may lead to combinatorial inhibition of oncogenic pathways and novel therapeutic targets. Here I address: (i) whether Armus participates in E-cadherin deregulation downstream of oncogenes, (ii) potential mechanisms through which Armus can switch between its function at junctions and autophagosomes and (iii) potential strategies to inhibit Armus intracellular localisation. I found that Armus is involved in Src and H-Ras disruption of E-cadherin junctions in keratinocytes. Armus binds to α-catenin at junctions, while at autophagosomes Armus interacts with autophagy marker, LC3. Incubation with Armus peptides containing LC3-interacting motifs partially blocks Armus function in autophagy. Mutation of the specific residues mediating α-catenin association reduces Armus localisation at cell-cell contacts. The close juxtaposition of LC3 and α-catenin binding at PH domain at Armus N-terminus may suggest additional roles. Armus N-terminus and RabGAP domain interact directly, and residue K480 is critical for binding. This intramolecular interaction may form a closed conformation, and Armus activation may require the release of this auto-inhibition. It is tempting to suggest that protein interactions at the PH domain such as LC3 and α-catenin may modulate Armus auto-inhibition. Alternatively, the phosphoinositide repertoire interacting with the PH domain may contribute to Armus intracellular distribution and activation. Further insights into Armus activation may provide greater understanding of its function in distinct cellular events with implications for tumourigenesis.
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Jenick, Marcus, and n/a. "Couples Coping With End-Stage Cancer: The Influence of Attachment, Emotional Support, and Positive Meaning on Psychological Adjustment and Each Other." Griffith University. School of Applied Psychology, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030804.121524.
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This thesis was concerned with the psychological adjustment of 67 end-stage cancer patients, and three psychosocial variables considered to influence that adjustment: emotional support from spouse, positive meaning, and working models of attachment. Furthermore, this thesis was also concerned with the psychological adjustment of the patients' spouses, and the influence of emotional support from patient and working models of attachment on their adjustment. It was hypothesised that each of these psychosocial variables would directly influence the psychological adjustment of patients and spouses, measured using the negative affectivity scale of the Positive and Negative Affect Scale (PANAS). Furthermore, it was hypothesised that emotional support would influence positive meaning, and working models of attachment would influence both emotional support and positive meaning. Variables were measured via paper and pencil self-report inventories, with the exception of positive meaning, where verbal responses to an open question were coded. Univariate analyses indicated an association between patients' and spouses' emotional support provided by one another and their psychological adjustment. Univariate results also showed that patients' positive meaning was related to patients' psychological adjustment, and that patients' working models of attachment involving higher levels of attachment anxiety were associated with patients' poorer psychological adjustment. All these individual associations remained statistically significant after three control variables related to the patients' physical condition were taken into account. In addition, univariate analyses indicated that attachment was associated with emotional support, and that emotional support was associated with positive meaning. Following univariate analyses, variables were integrated into one model for patients and another for spouses using path analyses. Results were generally consistent with the prior sets of analyses. However, patients' working models of attachment involving higher levels of attachment anxiety no longer had a direct effect on patients' psychological adjustment to statistically significant levels. Rather, the influence of the working models of attachment on patients' psychological adjustment was mediated by emotional support. In addition, patients' positive meaning no longer had a significant direct effect on patients' psychological adjustment. The insignificant path coefficients between attachment anxiety and psychological adjustment, and between positive meaning and psychological adjustment, were attributed to the large amount of variance in negative affect due to emotional support. In summary, this research indicates that emotional support given and received between patients and spouses is important to the psychological adjustment of each party. Furthermore, emotional support influences patients' ability to construe positive meaning in their illness, although positive meaning does not appear to be as critical to the psychological adjustment of patients as emotional support. Working models of attachment influence the psychological adjustment of patients primarily through their influence on emotional support.
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Jenick, Marcus. "Couples Coping With End-Stage Cancer: The Influence of Attachment, Emotional Support, and Positive Meaning on Psychological Adjustment and Each Other." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/365492.
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This thesis was concerned with the psychological adjustment of 67 end-stage cancer patients, and three psychosocial variables considered to influence that adjustment: emotional support from spouse, positive meaning, and working models of attachment. Furthermore, this thesis was also concerned with the psychological adjustment of the patients' spouses, and the influence of emotional support from patient and working models of attachment on their adjustment. It was hypothesised that each of these psychosocial variables would directly influence the psychological adjustment of patients and spouses, measured using the negative affectivity scale of the Positive and Negative Affect Scale (PANAS). Furthermore, it was hypothesised that emotional support would influence positive meaning, and working models of attachment would influence both emotional support and positive meaning. Variables were measured via paper and pencil self-report inventories, with the exception of positive meaning, where verbal responses to an open question were coded. Univariate analyses indicated an association between patients' and spouses' emotional support provided by one another and their psychological adjustment. Univariate results also showed that patients' positive meaning was related to patients' psychological adjustment, and that patients' working models of attachment involving higher levels of attachment anxiety were associated with patients' poorer psychological adjustment. All these individual associations remained statistically significant after three control variables related to the patients' physical condition were taken into account. In addition, univariate analyses indicated that attachment was associated with emotional support, and that emotional support was associated with positive meaning. Following univariate analyses, variables were integrated into one model for patients and another for spouses using path analyses. Results were generally consistent with the prior sets of analyses. However, patients' working models of attachment involving higher levels of attachment anxiety no longer had a direct effect on patients' psychological adjustment to statistically significant levels. Rather, the influence of the working models of attachment on patients' psychological adjustment was mediated by emotional support. In addition, patients' positive meaning no longer had a significant direct effect on patients' psychological adjustment. The insignificant path coefficients between attachment anxiety and psychological adjustment, and between positive meaning and psychological adjustment, were attributed to the large amount of variance in negative affect due to emotional support. In summary, this research indicates that emotional support given and received between patients and spouses is important to the psychological adjustment of each party. Furthermore, emotional support influences patients' ability to construe positive meaning in their illness, although positive meaning does not appear to be as critical to the psychological adjustment of patients as emotional support. Working models of attachment influence the psychological adjustment of patients primarily through their influence on emotional support.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Applied Psychology
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Rees, Jonathan. "Measurement of response shift in quality of life and symptom assessment in patients with advanced prostate cancer and their partners." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398668.
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Åström, Mathilda, and Katarina Lindström. "Stressreaktioner hos patienter med diagnostiserad prostatacancer och deras partner : Med kvalitetssäkring av enkät "Impact of Event Scale”." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-201440.
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Bakgrund: Prostatacancer är den vanligaste formen av cancer bland män i Sverige. Att få en cancerdiagnos innebär stress för både patienten och dess partner.Syfte: Syftet med denna studie var att undersöka grad av stressreaktioner i form av undvikande beteende och påträngande tankar hos patienter med prostatacancer och deras partner. Ytterligare ett syfte var att kvalitetssäkra mätinstrumentets formulering och svarsalternativ.Metod: Arbetet var en kvantitativ tvärsnittsstudie. Datainsamlingen gjordes med hjälp av enkät “Impact of Event Scale” (IES) samt en enkät utformad enligt “The Question and Answer Model” (QAM) för att kvalitetssäkra IES. Enkäterna delades ut på kirurg- och onkologmottagningar i Uppsala och Falun under våren 2013. Studiens inklusionskriterier var att de patienter som tillfrågades vid ankomst till mottagningarna hade prostatacancer och en partner (n = 34). 12 respondenter deltog. Data analyserades deskriptivt och med Mann- Whitey-test.Resultat: Det visade sig att patienter (n = 6) med prostatacancer har måttlig grad av stressreaktioner i form av undvikande beteende. Partner (n = 6) till patienter med prostatacancer visade sig ha kraftig grad av stressreaktioner i form av påträngande tankar. Det gick inte att se någon signifikant skillnad mellan patienter och partners grad av stress. Majoriteten av deltagarna i studien (n = 11) var säkra på sina svar i enkät IES.Slutsats: Partners tycks ha en högre grad av stress än patienter med prostatacancer, vilket går i linje med liknande studiers resultat. Interventioner för att nå denna grupp och se till dess behov är önskvärt. Fler studier fodras. Det övergripande resultatet tyder på att mätinstrumentet IES är av god kvalitet och mäter det som är avsett att mätas.Background: Prostate cancer is the most common form of cancer among men in Sweden.Getting a cancer diagnosis is stressful for both the patient and their partner.Objective: The aim of this study was to investigate the degree of stress responses in the form of avoidance behavior and intrusive thoughts in patients with prostate cancer and their partners. Another purpose was to assure the quality and design of the measuring instrument and its response options.Method: The study had a quantitative cross-sectional design. The data was collected using the questionnaire "Impact of Event Scale" (IES) and by a questionnaire framed according to "The Question and Answer Model" (QAM) to safeguard the quality of the IES. Questionnaires were distributed at surgical and oncology clinics in Uppsala and Falun during the spring of 2013. Inclusion criteria for the study were patients with prostate cancer and their partners (n = 34). 12 respondents participated. The data were analyzed descriptively and with Mann-Whitey test.Results: It was found that patients (n = 6) with prostate cancer have moderate degree of stress responses in the form of avoidance behavior. Partners (n = 6) were found to have strong degree of stress responses in the form of intrusive thoughts. Any significant difference between patients and partners dit not appear. The majority of study participants (n = 11) were confident of their answers in the IES.Conclusion: Partners seem to have a higher level of stress than patients with prostate cancer, which is in line with similar studies' results. Interventions to reach this group and ensure its need is desirable. More studies are lined. The overall results indicate that the measuring instrument IES is of good quality and are measuring the concepts that it indicate to measure.
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Mitchell, Claire. "Patient and partner perceptions of the patient's cancer : is discrepancy important?" Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5492/.
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Background: Research suggests that illness perceptions influence psychosocial outcomes across a range of chronic illnesses, including cancer. Such research traditionally takes an individualistic perspective, focusing on the patient. However, family members, in particular partners, play a crucial role in chronic illness and should be considered when examining adjustment. Partners also form illness perceptions about their partner’s illness, which may differ from the patient’s views, and some studies have found that such ‘discrepancy’ can be associated with negative psychosocial outcomes. However, the research in this area has produced mixed results and many studies neglect partner outcomes. Furthermore, there is little research exploring how perceptions evolve and are negotiated in couples. Aims: A quantitative study primarily aimed to examine associations between discrepancy in illness perceptions and quality of life in couples facing cancer, addressing limitations in previous research. A qualitative study aimed to develop understanding of how differences or similarities in perceptions develop and are negotiated in couples, and the role of discrepant perceptions within the adjustment process. Method: Thirteen couples completed questionnaires assessing their illness perceptions and health-related quality of life. This sample size was much smaller than anticipated due to recruitment difficulties and therefore the quantitative aims were not realised. For the qualitative study, six of the couples were interviewed both jointly and individually, with their data being analysed using the Voice-centred Relational Method and Interpretative Phenomenological Analysis. Results: Case studies highlighted that the evolution of couples’ understandings of the cancer was complex and idiosyncratic. Five group level themes were developed: unique roles and needs; in it together; outside influences; negotiations; and how we are left. These themes highlighted that couples balanced various complementary and competing perceptions that arose from the influence of numerous factors both within and outside the couple relationship. Balancing these multiple understandings required the use of various negotiation processes and attempts at negotiations varied in their ability to obtain a satisfactory resolution. Discrepancy was experienced both positively and negatively by the couples. Discussion: The recruitment difficulties that prevented some of the research aims being addressed are discussed. The qualitative findings are discussed in relation to the wider literature and clinical implications highlighted. Overall, the study highlights the importance of including partners in care provision and supports a relationship-centred approach to cancer.
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Morgan, Mary Ann. "Cancer Patients with Pain: Examination of the Role of the Spouse/Partner Relationship In Mediating Quality of Life Outcomes for the Couple." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002650.
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Huang, Li-Ting. "Investigating the Mutual Effects of Depression and Spiritual Well-being on Quality of Life in Hospice Patients with Cancer and Family Caregivers Using the Actor-Partner Interdependence Model." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6097.
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The World Health Organization and the leading hospice organizations have emphasized the inclusion of family caregivers of hospice patients with cancer into end-of-life care, as these two dyad members may spiritually and emotionally influence each other. Given that depression and spiritual needs, which are prominent in these pairs, may impair quality of life (QOL) of hospice dyads, examining mutuality within dyads is imperative to develop a more accurate model that includes family caregivers. Therefore, the purpose of the study was to elucidate the importance of mutual effects within hospice dyads by examining the contribution of depression and unmet spiritual needs on their personal and their counterparts’ QOL. Structural equation modeling was used to integrate the feature of actor and partner effects in the Actor-Partner Interdependence Model. After eliminating outliers, the final sample was comprised of 660 hospice dyads in which the majority of hospice patients were white (97%) and male (56.6%) with a mean age of 73 years. Most of the family caregivers were white (95.9%) and female (73.5%) with a mean age of 65 years. On average, hospice patients reported a depression score of 4.00 (SD = 1.53), and their family caregivers had a significantly lower mean depression score of 3.65 (SD = 1.48). With respect to their spiritual needs, 25.5% of hospice patients indicated going to religious services was an unmet need, and about 13% of family caregivers also reported that going to religious services was an unmet spiritual need, followed by being with friends, laughing, thinking happy thoughts, and being around children. The results of structural equation modeling revealed that depression and spiritual needs in cancer patients and family caregivers exhibited significant actor effects on the individual’s QOL after controlling for the partner effects. Among the spousal pairs, depression in family caregivers exhibited a positive partner effect on hospice patients’ functional well-being (β = .15, p < .05), implying that as depressive symptoms increase, hospice patients’ functional well-being increases. This study supported the need for considering both as one unit and the mutuality inherent in dyads. The findings of the study suggest the importance of consistent assessment in emotional and spiritual well-being for hospice patients as well as family caregivers, as their concerns may be transmitted to each other due to mutuality existing within the dyads.
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Dahl, Emelie, and Åsa Lindholm. "Skattning av ångest och depression hos prostatacancer patienter och deras partner : Kvalitetsäkring av frågeformuläret ”Hospital Anxiety and Depression Scale”." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200970.
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Syfte: Syftet med denna tvärsnittsstudie var att undersöka hur prostatacancer patienter och deras partner skattar sina eventuella nivåer av ångest och depression samt att undersöka om skattningen mellan dessa två grupper skiljer sig åt. Syftet är även att kvalitetssäkra frågeformuläret Hospital Anxiety and Depression Scale (HADS) enligt ”Question-and-Answer”-modellen. Metod: Kvantitativ tvärsnittsstudie med deskriptiv- och jämförande metod användes. Studien innefattade sex patienter samt sex partners, sammanlagt 12 personer. Datainsamlingen skedde med hjälp av enkäter. Resultat: Både patienterna och deras partners skattar relativt låga nivåer av ångest och depression. Vid deskriptiv analys av skattningen framkommer att partners skattar högre nivåer av både ångest och depression än vad patienterna gör. Studiedeltagarna har i de flesta fall angett att de ej påverkats av faktorerna i ”Question-and-Answer” modellen. Detta då de flesta av deltagarna var helt säkra på sina svar och de ansåg enkäten ej innehålla svårförståeliga ord eller att påståendena var otydligt formulerade. Slutsats: I denna förstudie sågs att partners skattade något högre nivåer av ångest och depression än patienterna. Detta är intressant och väcker behov av fortsatt forskning för att kunna dra några slutgiltiga slutsatser samt för att eventuellt kunna förbättra hjälp- och stödinsatser för dessa personer inom vården. Kvalitetssäkringen som utfördes visade att deltagarna ej påverkades av de fyra faktorerna i ”Question-and-Answer” modellen vilket tyder på att frågeformuläret HADS är väl utformat.Objective: The aim of this study was to investigate how prostate cancer patients and their partners estimate levels of anxiety and depression and whether the estimated levels differ between these two groups. The aim was also to assure quality of the Hospital Anxiety and Depression Scale (HADS) according to “Question-and-Answer” model. Method: A cross-sectional study with quantitative method was used. The study included six patients and six partners, a total of 12 people. Data collection was done using questionnaires. Results: Both patients and their partners reported relatively low levels of anxiety and depression. Partners reported higher levels of both anxiety and depression, than the patients themselves. The participants do not seem to have been influenced by the four factors in the "Question-and-Answer" model to a greater extent when they answered the HADS. The participants reported that they were confident of their answers and they considered that the survey did not contain incomprehensible words or that the allegations were vague formulated. Conclusion: In this preliminary study we found that partners estimated slightly higher levels of anxiety and depression than patients. This is interesting and raises the need for further research in order to draw any definitive conclusions and to improve the help and support interventions for these persons in care. Quality assurance that was carried out showed that the participants were not affected by the four factors in the "Question-and-Answer" model, which suggests that the HADS questionnaire is well designed.
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Cornish, Leah V. "Adolescent and young adult romantic relationships and cancer: Comparing patient and partner." Ohio University Art and Sciences Honors Theses / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1429266467.
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Lafaye, Anaïs. "Effets acteurs-partenaires du soutien social et des stratégies de coping sur la qualité de vie et les troubles anxio-dépressifs de patients atteints d'un cancer de la prostate et de leur conjointe." Thesis, Bordeaux 2, 2009. http://www.theses.fr/2009BOR21633/document.
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Le traitement d’un premier cancer de la prostate et les mois qui suivent, sont une période stressante pour les patients et leur conjointe. Les objectifs de cette étude sont, d’une part, de déterminer l’évolution de variables psychosociales (soutien social, qualité de la relation conjugale, ajustement dyadique et stratégies de coping) et du bien-être émotionnel et physique, et d’autre part, d’identifier les effets acteurs-partenaires, c'est-à-dire les effets des variables psychosociales d’un membre du couple sur son bien-être et sur celui de l’autre membre. Nous avons mené une étude longitudinale auprès de 132 patients atteints d’un cancer de la prostate et de 100 de leurs conjointes. Une évaluation psychologique leur a été proposée au début, au milieu, à la fin du traitement et quatre mois après. Les résultats montrent que les patients ont un état émotionnel et une qualité de vie satisfaisants et que les conjointes présentent une symptomatologie dépressive. Chez les patients, on observe des effets acteurs positifs du soutien social, de la relation conjugale et des stratégies de coping, centrées sur le problème ou sur la recherche de soutien social, sur leur bien-être, et des effets partenaires positifs de ces mêmes variables sur le bien-être de leur conjointe. Chez les conjointes, la relation conjugale a un effet acteur positif sur leur bien-être, mais le soutien social et les stratégies de coping centrées sur l’émotion ont des effets acteurs négatifs. De plus, l’effet partenaire soutien social des conjointes est positif sur le bien-être des patients, alors que celui des stratégies de coping centrées sur l’émotion est négatif. Celui de la relation conjugale est positif quand il s’agit de la disponibilité et de l’intensité du soutien, et négatif quand il s’agit de l’ajustement dyadique. De façon générale, le soutien social, la relation conjugale et les stratégies de coping sont de bons prédicteurs de la qualité de vie, directement ou par le biais du partenaireThe treatment of a first prostate cancer and the following months are a stressful period for the patients and their spouse. The first aim of this study was to determine the evolution of psychosocial variables (social support, quality of conjugal relationships, dyadic adjustment and coping strategies) and of emotional and physical well-being. The second aim was to identify actors-partners effects - that is the effect of one of partner’s psychosocial variables on his/her well-being and on that of the other. A longitudinal study was carried on 132 patients with prostate cancer and 100 of their spouses. A psychological evaluation was conducted at the beginning, half way through, at the end of the treatment and four months afterwards. Results showed that patients had a good emotional state and a good quality of life and, that the spouses developed a depressive symptomatology. For patients, positive actor effects of social support, conjugal relationships and coping strategies (problem-focused or seeking social support focused) on their well-being and, positive partner effects of the same variables on the spouses’ well-being were observed. For the spouses, conjugal relationships had a positive actor effect on their well-being, but social support and emotion-focused coping strategies had negative actor effects. Also, spouses’ social support had a positive partner effect on the patients’ well-being while emotion-focused coping strategies had a negative effect. Conjugal relationship effect was positive when referring to availability and intensity of support and, negative when referring to dyadic adjustment. Overall, social support, conjugal relationship and coping strategies were found to be good predictors of quality of life, directly or indirectly through the partner
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Thompson, David R. "Efficacy of counselling for coronary patients and partners." Thesis, Loughborough University, 1989. https://dspace.lboro.ac.uk/2134/10880.
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The purpose of this study was to monitor and compare levels of anxiety, depression, satisfaction and knowledge in male coronary patients and their spouses, throughout the patients stay in hospital and at one, three and six months following discharge from the hospital. A programme of in-hospital educative-supportive counselling was introduced to determine whether it significantly affected reactions. The study design took the form of a randomized controlled trial. The counselling was provided to couples during four 30 minute sessions by a coronary care unit registered nurse. Findings from the study provide evidence to support the overall contention that this simple programme confers additional benefits over and above the usual management regime. These benefits include statistically significant reductions in reported anxiety and depression, and increases in satisfaction and knowledge in both partners. The programme of support was simple and easy to implement, requiring little investment in training personnel and none in additional staff, finances or other resources. It is concluded that in-hospital counselling for coronary patients and partners is therapeutically effective and efficient. Proposals are made for practice change and recommendations are given for the direction of future research.
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Hinnen, Stefan Cornelis Herman. "Distress and spousal support in women with breast cancer." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/305351095.
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Näsström, Lena. "Participation in heart failure home-care : Patients’ and partners’ perspectives." Doctoral thesis, Linköpings universitet, Avdelningen för omvårdnad, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-117095.
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Introduction: Patient participation is important for improving outcomes and respecting selfdetermination and legal aspects in care. Heart failure is a chronic condition that puts high demands on self-care and patient participation. Patients often need advanced care due to deterioration of their heart failure symptoms, and one option is to provide care as home-care. There is limited knowledge of how patients with heart failure and their partners view participation in home-care. Aim: The overall aim of this thesis was to describe different perspectives of participation in structured heart failure home-care among patients with heart failure and their partners. Methods: All patients in this thesis received structured heart failure home-care, according to a model aiming to facilitate care, where safety, participation, and gaining knowledge about the illness and treatment, are in focus. Study I had a prospective pre-post longitudinal design including 100 patients with heart failure receiving home-care. Data was collected by selfadministered questionnaires. Study II had a descriptive design. Nineteen patients receiving home-care were interviewed, and data was analysed using qualitative content analysis. Study III had a descriptive and explorative design. Data was collected by video-recorded observations of 19 home visits and analysed by qualitative content analysis. Study IV had a parallel convergent mixed-method design including 15 partners of patients receiving structured home-care. Data was collected by interviews and self-administered questionnaires. Datasets were first analysed separately and then together. Results: Better self-care behaviour was significantly associated with all measured aspects of participation. Participation by received information increased significantly during the 12-month follow-up (I). Patients’ descriptions of participation included communication between patients and health care professionals, access to care, active involvement in care, a trustful relation with health care professionals, and options for decision-making(II). Observed care encounters revealed that participation was made possible by; (i) interaction, including exchange of care-related information, care-related reasoning, and collaboration, (ii) an enabling approach, including the patient expresses own wishes and shows an active interest, and the nurse is committed and invites to a dialogue (III). Partners scored fairly positive for their participation in care and they performed different levels of caregiving tasks. Descriptions of participation included; adapting to the caring needs and illness trajectory, mastering caregiving demands, interacting with care providers, and gaining knowledge to comprehend the health situation. The mixed-method results showed both convergent results and expanded knowledge (IV). Conclusions: Structured heart failure home-care facilitated participation both for patients and their partners. Patient participation with regard to received information improved significantly after receiving home-care. Aspects of patient participation were consistently associated with better self-care behaviour. Patients’ and partners’ descriptions revealed many aspects of participation, and observed home visits revealed how interaction and an enabling approach underpinned participation.
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Zvieriev, Valerii. "Implications of CD9 and its partners in prostate cancer progression." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111833.
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Prostate cancer is still the most diagnosed cancer in man in the Western world and in this group, one of the leading causes of cancer death. CD9 protein is a member of the tetraspanin family, whose members are often down-regulated in advanced prostate cancers. The objective of our study is to decipher the role of the CD9 protein in prostate cancer progression.We have demonstrated that over-expression of exogenous CD9 in highly tumorigenic and metastatic PC-3M-LN4 cell line did not suppress its tumorigenic and metastatic properties in vivo while it even increased its invasive properties in vitro. These data contrast with our previous study, which demonstrated that over-expression of wild type CD9 has a deleterious effect on growth properties of human PC-3 prostate cancer cells in vitro. Since CD9 is still expressed in some human prostate cancers, we linked putative inactivation of CD9 in PC-3M-LN4 cells with presence or absence of certain CD9 partners. Using co-immunopreciptation, mass-spectrometry, Bacterial two-hybrid system and Ciphergen ProteinChip technology we identified six novel CD9 protein partners, namely MORTALIN, OVCA2, HES4, GALECTIN3, RAB5A, TM4SF9. These partners could affect CD9 function in prostate cancer cells. We also detected ASPP2 protein expression only in PC-3 cells.
Pursuing the characterization of some of these partners, we showed that simultaneous over-expression of CD9 and OVCA2 in PC-3M-LN4 cells lead to mitotic catastrophe and eventually cause cell death.
Furthermore, immunocolocalization studies demonstrated that CD9 and MORTALIN interaction depend on CD9 over-expression in an appropriate cell context, putatively explaining the differential effect of CD9 in PC-3 and PC-3M-LN4 prostate cancer cells.
Overall, the data presented in this thesis demonstrated that the biological properties of CD9 protein are dependent on protein-protein interactions and cell type environment. The demonstrated interactions of CD9 with OVCA2 and MORTALIN highlighted the importance of CD9 as a potential tumor and/or metastasis suppressor gene.
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Engler, Jennifer [Verfasser]. "Cancer Care and Cancer Patients’ Experiences with Cancer / Jennifer Engler." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1180994191/34.
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Pelusi, Jody Louise. "Cancer survivorship: The other side. The lived experience of partners of long-term breast cancer survivors." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284071.
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As the number of women diagnosed with early stage breast cancer continues to rise, so does the population of long-term breast cancer survivors. Many factors influence the overall outcome of their experience, one of which is the support from their partners. Much has been written on the issues of women with breast cancer, but what is lacking in the literature are the voices of their partners during the long-term survival phase of the disease. The purpose of this study was to conduct a phenomenological study to (1) describe the essential structure of the experience of being a partner of a long-term breast cancer survivor, and (2) compare theme patterns of the partners of long-term breast cancer survivors with those of long-term breast cancer survivors. The sample consisted of seven participants with the average age of 55 years. Time together as partners averaged 25.2 years. The average time since the cancer diagnosis was 9.5 years. The research method consisted of open-ended audiotaped interviews. Colaizzi's eight-step method of analysis was utilized. Ten theme categories were identified from the data: the invisible enemies--cancer and uncertainty, a sense of duty, constant vigilance, from dreams to reality, turning my eyes away but not my heart, paying the price, don't worry--be happy, who are we now, rebuilding our home, and the everlasting journey. From these theme categories, the essential structure was identified. In searching for the meaning of the journey, the partner is influenced by several factors: their own as well as the patient's coping skills and quality of life, as well as the patient's overall response to cancer treatment. Partners experience many of the same issues as the patient, but their response to and the ability to travel along this cancer journey is based on their role as a partner and their sense of duty to the patient. The partner's goal is to bring structure and stability to the uncertainty of cancer and to find meaning for oneself and the patient during this experience.
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OLSSON, MILLA, and CAROLINE ROSELL. "Telemedicine for Lung Cancer Patients." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-136951.
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Den svenska sjukvården står idag för ett antal utmaningar om den skall fortsatt kunna erbjuda god service som vårdgivare och vara attraktiv som arbetsgivare. Bland annat diskuteras frågor som förvärrad platsbrist, läkarbrist samt avstånd till specialistsjukvård. På Karolinska Universitetssjukhuset i Solna ligger Radiumhemmet och där behandlas bland annat lungcancerpatienter. Där diskuteras huruvida telemedicin kan vara en möjlig väg för att lösa ovanstående problem. Denna uppsats utreder på vilket sätt telemedicin kan användas på Radiumhemmet för lungcancerpatienter. För att kunna utreda en telemedicinsk lösnings möjligheter på Radiumhemmet genomfördes intervjuer och fokusgrupper med personalen. Externa experter från sjukvården och industri intervjuades och ett besök gjordes på barnsjukhuset Childrens Healthcare of Atlanta, USA, där man har kommit långt i användningen av telemedicin. Det finns delar av verksamheten på Radiumhemmet där telemedicin skulle kunna bidra till att skapa möjligheter till en tätare kontakt mellan patient och vårdpersonal. Detta i syfte att lugna oroliga patienter och hjälpa till med lättare symptombedömningar och på så sätt minska väntetiderna. Genom de undersökningar som utfördes upptäcktes dock även svagheter i en telemedicinsk lösning avsedd för lungcancerpatienter. Patientgruppen ofta är äldre med liten erfarenhet av datorer och sjukdomen är allvarlig. Det krävs personlig kontakt och fysiska undersökningar, men i vilken utsträckning är individuellt. Telemedicin kanske inte kan ses som en absolut lösning för de problem som råder i sjukvården idag när det kommer till lungcancerpatienter, men väl som ett komplement. Om lungcancerpatienter är den optimala målgruppen är ifrågasättbart men att telemedicin kan underlätta i den svenska sjukvården står klart.Nowadays the health care system in Sweden is faced with several challenges like shortage of space, physicians and long distances to specialized health care. A possible solution for this being discussed at the lung cancer department of Karolinska University 2 Hospital is the use of telemedicine. If implemented it would be part of the followup treatment. The objective of our research is to find out if this technology can help improve the health care. In order to investigate the opportunity for a telemedicine solution, we collected qualitative data from multiple different sources. This included two doctors specialized in lung cancer, and a focus group with nurses from Radiumhemmet. We also conducted interviews with relevant individuals outside the hospital including Nirav Desai who is the Founder and CEO of Hands On Telehealth; furthermore, we visited the Children’s Healthcare of Atlanta based in Atlanta, Georgia where telemedicine is used on a daily basis. Thanks to the carried out research, we have discovered that telemedicine could be used in certain scenarios and contribute towards a more frequent contact between the patient and the medical professionals. Thus, this new technique could help nurses execute lighter symptoms assessment remotely and reduce waiting times. We also discovered some inconveniences in a telemedicine solution designed for lung cancer patients. We personally do not think they are the best target group for such a solution since the patients are mostly the elderly with little computer experience. Also the disease is severe and requires physical examinations where the telemedicine existing today would not improve the care giving. To all intents and purposes, telemedicine might not be the only and ultimate solution for the problems identified within healthcare for lung cancer patients at Radiumhemmet, but it can work well as a supplement. 3
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Fredrix, Elisabeth Wilhelmina Hubertina Maria. "Energy metabolism in cancer patients." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1990. http://arno.unimaas.nl/show.cgi?fid=5567.
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Kaur, Jasmine. "Preventative Vaccine for Cancer patients." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/413312.
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Cancer is an age-old disease and a leading cause of mortality worldwide. It starts with the development of abnormal cells that multiply to form tumours and may lead to metastasis causing damage to healthy tissues and organs of the body. Lung cancer is the most common type of cancer with significant morbidity and mortality globally and is of major concern for the society. Decades of research and innovation in the treatment of cancer led to the development of certain conventional therapies such as surgery, radiotherapy, and chemotherapy that are being effectively used. However, these traditional therapies have a disadvantage of destroying healthy cells and tissues in its close proximity, leading to other severe diseases and side effects. Therefore, a much-advanced approach to treat cancer without causing severe side effects became an important area of research. Improvements in the field of anti-cancer therapies led to a strategy to combine traditional treatment approaches to destroy cancer cells. Additionally, treatments such as targeted therapies, hormone therapy, and precision medicine came into existence. Alternatively, the immune system was analysed to determine an effective approach that could control proliferation of cancer cells and cause limited or no damage to other cells. This area of cancer therapeutics, known as immunotherapy, targets the immune system to enhance its ability of recognizing invasive neoplasms. Our immune system in response to an infection immediately activates immune cells, creating a protective immunity for decades. Unfortunately, this immune response often fails when fighting against cancer and is unable to entirely eliminate tumour cells or develop effective immunity. Cancer vaccines, a branch of immunotherapy that has potential therapeutic benefits can build immunity and ultimately lead to prevention from future illness. These have been employed to treat the disease using tumour associated antigens and various adjuvants or immune stimulators and only a few have been in clinical trials. The potential of such cancer vaccines can be exploited to further develop treatment strategies to prevent tumour occurrence and provide long-lasting immunity. This study was designed to primarily explore the potential of a novel immune stimulator, RNA:DNA hybrid and an established TLR9 agonist, CpG 7909. Furthermore, these agonists were used to develop a preventative cancer vaccine in association with a tumour associated carbohydrate antigen, Globo-H to determine whether the novel formulation could improve immune response and trigger antigen presentation in vitro and in vivo. In an in vivo setting, these were also investigated against lung cancer to determine their potential in preventing tumour occurrence. Within this study RAW 264.7 mouse macrophages were initially exposed to varying concentrations of CpG 7909, RNA:DNA hybrid, and Globo-H to determine the optimum dose concentration for the activation of antigen presenting cells by measuring the level of TNF-α secreted in cell culture supernatant. Following dose optimization, the individual agents were combined in a vaccine formulation, sharing the same antigen, where two cell lines, mouse RAW 264.7 macrophages and human monocytic cell line, THP-1 that was differentiated into macrophages and dendritic cells were exposed to the vaccines. TNF-α, IL-12 and IL-6 cytokine response was analysed as measured by ELISA and real-time PCR that were determined to be partially significant in response to the vaccines. The degree of immune response demonstrated by RNA:DNA hybrid-based vaccine (HG-Vax) confirmed that HG-Vax is more effective than CpG 7909-based vaccine (CG-Vax). This response was further analysed in an in vivo model where C57/BL mice were exposed to immune stimulators and vaccines separately for 14- and 28-days before end point termination. Serum was analysed for IL-12 and TNF-α to determine the level of inflammatory response. Even though statistical significance was not achieved in vivo, contrasting observations compared to the in vitro model were exhibited. Secretion of IL-12 in animals confirmed the induction of an anti-tumour immune response. Interestingly, cytokines induced by single dose CG-Vax persisted for a longer period of time in blood in comparison to HG-Vax. However, opposite was true with the booster immunization. In animal model of lung cancer, statistical significance validates that booster immunization with HG-Vax triggers an immune response and upregulates MHC II expression. Unfortunately, CG-Vax did not induce a significant immune response and failed to induce MHC II expression in an in vivo model of lung cancer. Although these findings present RNA:DNA hybrid to be a novel immune stimulator that may have the potential to be used in future cancer vaccinations, further investigation on its immunological potential and mechanism of action remains of need.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Pharmacy & Med Sci
Griffith Health
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Reid, Suzanne Shirley. "Friend or intruder? : Living with an implantable defibrillator : patients' and partners' experiences /." Electronic version, 2001. http://adt.lib.uts.edu.au/public/adt-NTSM20041104.172632/index.html.
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Bender, Alexis A. "Patients, Partners, and Practitioners: Interactions and Meaning- Making Following Spinal Cord Injury." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/sociology_diss/57.
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Sustaining a Spinal Cord Injury at any point in time is life altering – physically, emotionally, and financially – for all persons affected by the injury, but it can place unique challenges on younger married couples. This study examines the transition to injury for 18 couples (ages 21-55). Data were collected using individual interviews with each partner at three time points following injury, as well as observation in the rehabilitation setting (Creekview). This resulted in 96 individual interviews and 300 hours of observation. Using a combination of the life course perspective and cognitive sociology as guiding theoretical frameworks and grounded theory analysis, I examined how the health care institution influenced the couples’ relationships during their rehabilitation stay and the subsequent transition home. Overall, this study found that Creekview shaped a thought community that emphasizes a return to walking and high levels of physical recovery. Patients who achieved these goals constructed positive narratives about the future while those with lower levels of recovery constructed negative narratives over time. Additionally, because of the dominant medical narrative of wait and see regarding physical recovery, many respondents constructed fuzzy narratives about the future that reflect ambiguity about what life would look like following injury. Additionally, Creekview staff and couples accepted and reinforced the dominant cultural narrative that women are natural caregivers, but larger social structures of class, gender, and the division of paid and unpaid labor work together to push some women into caregiving faster or prevent other women from engaging in caregiving. Expanding on Aneshensel et al.’s (1995) caregiving career, this study examines how younger couples move through the caregiving career when the expected outcome is not long-term care placement or death. This study identified three main types of caregivers, each with their own path of caregiving – Naturalized, Constrained, and Resistant caregivers. Overall, the transition to injury is complex for patients and partners and this study highlights some of the ways the marital relationship is affected by a non-normative, unexpected transition.
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Sharma, Neil. "Novel binding partners of PBF in thyroid tumourigenesis." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4766/.
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Thyroid cancer is the most common endocrine cancer, with a rising incidence. The proto-oncogene PBF is over-expressed in thyroid tumours, and the degree of over-expression is directly linked to patient survival. PBF causes transformation in vitro and tumourigenesis in vivo, with PBF-transgenic mice developing large, macro-follicular goitres, effects partly mediated by the internalisation and repression of the membrane-bound transporters NIS and MCT8. NIS repression leads to a reduction in iodide uptake, which may negatively affect the efficacy of radioiodine treatment, and therefore prognosis. Work within this thesis describes the use of tandem mass spectrometry to produce a list of potential binding partners of PBF. This will aid further research into the pathophysiology of PBF, not just in relation to thyroid cancer but also other malignancies. From this list, the interaction with three proteins was further investigated and validated by GST pull-down assays and/or co-immunoprecipitation. Thyroglobulin is an essential component of thyroid hormone synthesis. Preliminary studies suggested co-localisation with PBF within intra-cellular vesicles, although further research is needed to explore this functionally. Cortactin has a role in the cellular transport of proteins, and also promotes invadopodia formation and metastases in cancer. Co-localisation was observed in vesicles and at the membrane, with PBF additionally demonstrated in cell membrane projections – indicating a potential mechanism for the shuttling of PBF to and from the cell membrane, and its secretion. SRC is a tyrosine kinase intimately linked to cancer. SRC phosphorylated PBF, an effect abrogated by treatment with specific inhibitors, including PP1. Importantly, PP1 treatment was then found to increase iodide uptake in human primary thyroid cultures over-expressing PBF. Overall, these data describe a list of possible binding partners for PBF, and specifically identify a novel potential therapeutic strategy for iodide-refractory thyroid cancer.
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Moriconi, Christine Barbera. "A systematic treatment program of mindfulness meditation for fibromyalgia patients and their partners." View full text, 2003.
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Jackson, Katy Filer. "The experiences of partners of cardiac patients : sense of coherence and cardiac beliefs." Thesis, City University London, 2011. http://openaccess.city.ac.uk/7798/.
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The cardiac literature has shown that the stress of a patient’s illness may increase the partner’s vulnerability to develop psychological and physical illness. However, not all partners experience a crisis in response to the patients’ illness. The following study explored the experiences of being a partner of a person with cardiac problems. The aims of the study were a) to determine whether cardiac partners were distressed b) to investigate the reasons for the partners distress c) to explore the relationship between sense of coherence, cardiac beliefs and levels of partners distress d) to identify gaps in the care provided and opportunities for service development. A cross-sectional questionnaire study, followed by smaller scale interviews of partners of patients eligible for cardiac rehabilitation was conducted. 89 partners completed a questionnaire which included data on a) The “Sense of Coherence Scale” (SOC); b) cardiac beliefs; c) HADS; d) general questions on demographics problems, needs and experiences. Following analyses of the questionnaire, it was decided that the interviews would focus on the group of partners with the lowest HADS scores, as they would benefit the most from additional support. 8 partners were interviewed. In general, the sample of partners was in good health and coping well. The linear regression analysis showed that the partners’ sense of coherence and cardiac beliefs accounted for 62.5% of the variance in the partners psychological distress. Out of the two variables, SOC was a better predictor of HADS. The main reasons for partners’ dissatisfaction and distress included poor health, caregiver burden, conflict within the relationship, and inadequate support from health professionals. A framework of partners interventions was discussed, so that partner interventions would become both an integral and an intrinsic part of nursing care. The cardiac beliefs questionnaire has a valuable role in cardiac partner interventions, not only as a research tool, but also as a, cost effective, easy to deliver clinical intervention. The SOC would provide cardiac staff a framework to organise both the questions that they ask the partners and the information that they provide them. In addition to providing support for partners in distress, a salutogenic framework could help staff promote the resources to ensure that the non-distressed partners (and patients) remain healthy.
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Mcdougall, Fiona. "How do partners' beliefs about chronic pain relate to patients' acceptance of pain?" Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/47284/.
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Background: It is now widely acknowledged that pain acceptance predicts a wide range of functional outcomes in chronic pain patients. Whilst there has been considerable research into individual factors that contribute to acceptance, little is known about the impact of social relationships on this process. Aims: This thesis aims to explore how spouse’s beliefs about pain, and their responses to patients when in pain, impact on patient acceptance. Second, the role of catastrophic thinking and acceptance will be explored in relation to psychological distress. Method: A cross-sectional survey design was used with 61 patients and their partners recruited at a specialist chronic pain service. Patients completed the Chronic Pain Acceptance Questionnaire, the Pain Catastrophising Scale, and the Hospital Anxiety and Depression Scale in addition to measures of pain severity, functional disability, and socio-demographic information. Partners completed the spouse version of the Pain Catastrophising Scale which explores their beliefs about their partner’s pain. Results: Both depressive and anxious symptoms were common in this sample, with 49% and 58% respectively experiencing at least mild symptoms. Pain catastrophising and acceptance scores were significantly correlated with psychological distress, functional disability and pain severity. After adjusting for confounders, the CPAQ was a significant predictor of depression but not anxiety. Pain catastrophising was a significant predictor of both depression and anxiety. The addition of spouse catastrophising significantly improved the model for the prediction of anxiety. Patient and spouse catastrophising scores were both significant independent predictors of acceptance after adjusting for confounders. There was a significant effect of the interaction between patient and spouse catastrophising on acceptance, such that when patient catastrophising was low, low catastrophising in spouses was associated with greater acceptance, but when patient catastrophising was high, catastrophising in spouses had no effect. Neither the CPAQ total score nor its subscales were significantly correlated with spouse responses to pain. Conclusions: These findings suggest that spouse catastrophising can impact on both patient acceptance and psychological distress. Understanding a spouse’s beliefs about their partner’s pain may be an important factor in achieving greater acceptance in patients.
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Young, Kate. "Partners not patients: Healthcare for endometriosis from the perspectives of women and clinicians." Thesis, Monash University, 2018. https://monash.figshare.com/articles/Partners_not_patients_Healthcare_for_endometriosis_from_the_perspectives_of_women_and_clinicians/7452971.
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Endometriosis is a chronic inflammatory condition experienced by women. Little is known about the disease or how to support those who live with it. I examined healthcare for endometriosis from the perspectives of women and clinicians to identify how care can address women’s needs. I conducted in-depth interviews with 26 women of various sociodemographic and endometriosis experience profiles, and semi-structured interviews with 12 clinicians (general practitioners, gynaecologists). Through a social constructionist framework, I analysed these interviews and identified that, to address the complexities of endometriosis, clinicians must be supported to incorporate women’s knowledge and perspectives into care.
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McMenamin, Úna. "Pharmacological exposures, cancer treatments and disease progression among cancer patients." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679267.
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The evidence base for the effect of common pharmacological exposures among patients diagnosed with cancer is sparse. Routinely collected health data however, can facilitate the conduct of pharmacoepidemiological research into cancer care and outcomes. This PhD study comprised (i) a systematic review of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) use and cancer progression and survival; (ii) a systematic review and meta-analysis of non-steroidal anti-inflammatory drug (NSAID) use and colorectal cancer outcomes; (iii) a nested-case control study of ACEI and ARB use and risk of breast cancer mortality; (iv) a nested-case control study of ACEI and ARB use and risk of prostate cancer mortality and; (v) an overview of cancer treatments received among women, recently diagnosed with breast cancer in Northern Ireland. Individual studies identified within the first systematic review showed inconsistencies with respect to the association between ACEls/ARBs and cancer outcomes and following on from this, findings from two large population-based studies indicated little evidence of a beneficial association between ACEI or ARB use and breast and prostate cancer mortality outcomes, respectively, although a possible protective association was noted for ACEls and risk of prostate cancer mortality. Similarly, there was limited evidence to suggest an association between NSAID use and clinical outcomes from colorectal cancer, based on findings from the second systematic review and meta-analysis. Using data sources from within the Northern Ireland Cancer Registry, a retrospective population-based dataset of breast cancer patients, recently diagnosed in Northern Ireland was constructed. Cancer treatments were deemed appropriate and particular attention was given to adjuvant systemic therapies (including chemotherapy and hormone therapy). This dataset will enable future data linkage with dispensed medication records. Considering the frequency with which ACEls, ARBs, as well as NSAIDs are prescribed, further research into cancer outcomes with respect to these agents is warranted.
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Wolfman, Jessica Heather Kloss Jacqueline D. "Cancer specific stress and insomnia severity among breast cancer patients /." Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3024.
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Radu, Calin. "Optimising Radiotherapy in Rectal Cancer Patients." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172531.
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Rectal cancer is the eight most common cancer diagnosis in Sweden in both men and women, with almost 2000 new cases per year. Radiotherapy, which is an important treatment modality for rectal cancer, has evolved during the past decades. Diagnostic tools have also improved, allowing better staging and offering information used to make well-founded decisions in multidisciplinary team conferences. In a retrospective study (n=46) with locally advanced rectal cancer (LARC) patients, unfit for chemoradiotherapy, patients were treated with short-course radiotherapy. Delayed surgery was done when possible. Radical surgery was possible in 89% of the patients who underwent surgery (80%). Grade IV diarrhoea affected three elderly patients. Target radiation volume should be reduced in elderly or metastatic patients. In a prospective study (n=68) with LARC patients, magnetic resonance imaging (MRI) and 2-18F-fluoro-2-D-deoxyglucose (FDG) positron emission tomography (PET) were used to determine if FDG-PET could provide extra treatment information. Information from FDG-PET changed the stage of 10 patients. Delineation with FDG-PET generally resulted in smaller target volumes than MRI only. Seven of the most advanced LARC patients in the above cohort were used for a methodological study to determine if dose escalation to peripheral, non-resectable regions was feasible. Simultaneous integrated boost plans with photons and protons were evaluated. While toxicity was acceptable in five patients with both protons and photons, two patients with very large tumours had unacceptable risk for intestinal toxicity regardless of modality. In the interim analysis of the Stockholm III Trial (n=303, studying radiotherapy-fractionation and timing of surgery in relation to radiotherapy) compliance was acceptable and severe acute toxicity was infrequent, irrespective of fractionation. Short-course radiotherapy with immediate surgery tended to give more postoperative complications, but only if surgery was delayed more than 10 days after the start of radiotherapy. Quality-of-life in the Stockholm III Trial was studied before, during and shortly after treatment using the EORTC QLQ-C30 and CR38 questionnaires. Surgery accounted for more adverse effects than radiotherapy in all groups. Postoperatively, the poorest quality-of-life was seen in patients given short-course radiotherapy followed by immediate surgery. No postoperative differences were seen between the two groups with delayed surgery.
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Nna, Emmanuel Okechukwu. "Molecular profiling of prostate cancer patients." Thesis, Cranfield University, 2009. http://dspace.lib.cranfield.ac.uk/handle/1826/4527.
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In the UK, more than 30 000 men are diagnosed annually with prostate cancer (PCa) and about 10 000 men die from it each year. Although several molecular markers have been associated with prostate cancer development and/ or progression, only few of them are used in diagnostic pathology. The current standard tests include serum PSA test, digital rectal examination and histology of prostate biopsy. Recently the PCA-3 molecular test was approved in the European Union, and it is now used in many laboratories. But these tests are not sufficient to molecularly characterise the behaviour of prostate cancer in many patients. Through extensive literature review, a panel of sixteen molecular markers were selected for further evaluation in prostate cancer cases. They included KLK2, KLK3, MCM2, MCM5, TP53, Bcl-2, CD44, CDH1, AURKA, AURKB, and AURKC; ESR , ESR , AR, FASN, TMPRSS2: ERG, and TMPRSS2:ETV1. The aim was to examine the link between development/progression of prostate cancer and the production of diagnostic/prognostic biomarkers. An in vitro model consisting of PC-3 and PNTIA, MDA PCa 2b prostate cell lines were used to investigate the influence of steroid hormones on these biomarkers using molecular and proteomic techniques. All the three cell lines expressed AR, ESR , ESR and PSA at mRNA and protein levels. The AR expressed in PC-3 and MDA PCA 2b cells was 60 kDa while the PNT1A expressed a 90 kDa AR protein. The ESR was over-expressed in the MDA PCA 2b cells, and was also significantly up-regulated by 17 oestradiol treatment. At a concentration of 4.92 and 33.96μM 17 oestradiol inhibited the growth of 10 to 50% of PNT1A cell line and increased the doubling time three folds. Although the PC-3 cells expressed AR, it was still androgen insensitive and could not produce PSA in culture supernatants. AR and PSA were up-regulated in PNT1A cells in response to testosterone and dihydrotesterone treatment but were reduced in response to 17 oestradiol and Hydrocortisone treatment. All the molecular markers except the TMPRSS2: ERG and TMPRSS2:ETV1 were expressed in the cell lines. The MCM2 and MCM5 were not differentially expressed in response to hormonal treatment. However, the Aurora kinases A, B and C were up-regulated in response to steroid modulation. The KLK2 was only up-regulated by the androgens. Three candidate control genes: ABL1, GUS and G6PD were also evaluated in the cell lines and clinical samples; the ABL1 gene emerged as the most stably expressed house keeping gene and was subsequently used in the normalization of real time PCR assays (RQ-PCR). Analysis of the sixteen biomarkers in prostate tissues and exfoliated urine cells of benign, prostate cancer and non-involved cases (n = 228) showed that seven of the molecular markers were significantly strongly associated with prostate cancer progression (P<0.05). The Aurora kinases A and B were consistently significantly over-expressed in prostate cancer cases. The CD44 was also over-expressed in prostate cancer, and was associated with Gleason score. The TMPRSS2 fusion genes were detected in 15.6% of the prostate cancer cases. The TP53 was also over-expressed in prostate cancer, and significantly associated with tumour grade. The ESR was over-expressed in prostate cancer, and was significantly associated with high tumour grade. This implied a proliferative role for the ESR in prostate cancer progression, because the ESR was not differentially expressed among the sample groups. Concomitantly, the AR was also over-expressed in same pattern with ESR . The combination of these biomarkers: AR, ESR , CD44, TP53, TMPRSS2 fusion genes, AURKA and AURKB could molecularly characterise most prostate cancers. Therefore 2 sets of pentaplex RQ-PCR assays including ABL1 for normalization would provide a cost-effective, flexibly high throughput assay for molecular grading of tissue sections in diagnostic pathology. In addition to the gene expression studies, the genetic variation in KLK2 gene was further investigated by direct DNA sequencing, pyrosequencing and TaqMan allelic discrimination assay. Two SNPs in the gene were found significantly associated with prostate diseases. The T/T allele of rs198977 predicted the presence of prostate cancer at biopsy and was associated with high tumour grade. The A/A variant of rs2664155 was also significantly associated with the presence of benign nodular hyperplasia. The combination of gene expression and genetic variation using real time PCR applications would provide an accurate, reproducible and cheap method for molecular profiling of prostate cancer patients. An exploratory study of organic volatiles in urine of one prostate cancer patient and eight BPH patients using thermal desorption GC-MS showed that Ethanethiol, Dimethyl sulfide, Propyn-1-ol acetate, Nitro-2-propanone, pentane, Hydrazine and Nitrous oxide were differentially over-expressed in the prostate cancer patient compared to the benign cases. Further studies would be required to rule out possible contamination and drug metabolites.
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Viganó, Antonio Angelo Luciano. "Survival predictors in advanced cancer patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0007/MQ28996.pdf.
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Persson, Christina. "Improved Nutritional Support in Cancer Patients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5218-3/.
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Chan, Chun-wai Raymond. "Bereavement of spouses of cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B29726694.
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Dhanbhoora, Khushnud A. "Spousal communication among patients with cancer." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1364940.
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Using primarily grounded theory methodology, the purpose of this study was to understand how the experience of cancer affects communication patterns in married couples where one spouse has been diagnosed with cancer. Nine couples, five in which women were diagnosed with cancer and four in which men were diagnosed with cancer, were interviewed individually. They were asked questions pertaining to changes in their relationship and communication patterns since the diagnosis of cancer. Potential barriers and facilitators to communication were explored. Additionally, gender differences that could play a role in these marital communication patterns were examined. Participants were also administered a measure of mood states, the Profile of Mood States (POMS) and, a measure of family cohesion, flexibility and communication, the Family Adaptability and Cohesion Evaluation Scale-version IV (FACES IV). Findings from both qualitative and quantitative methods were triangulated.Information gathered from the interviews generated eight themes: initial reactions to diagnosis, the experience of cancer, coping strategies, impact of cancer on the spousal relationship, spousal communication prior to cancer, spousal communication since the diagnosis of cancer, barriers to communication, and impact of gender and gender role on communication and adjustment. These categories and their subcategories generated an integrated grounded theory on the dimensions of communication. The theory consisted of three interactive elements: facilitators of communication, barriers to communication and the role of gender.Findings from this study confirmed existing trends in the current literature on communication among couples facing cancer. Results demonstrated that the experienceof cancer and its treatment brought couples closer to each other, where they experienced increased intimacy and communication with their spouses. There were several factors that facilitated these changes. On the other hand, barriers to communication were also identified; however, some of these barriers also served as coping strategies for participants. Furthermore, although there were differences and similarities noted among men and women in the study, results highlighted the importance of viewing them within the context of each participant's role as a patient and a caregiver, and not merely as a result of gender.Several research and practice implications are presented. Results of this study can help health care and mental health professionals gain a better understanding of the needs of cancer patients and their families. Couples and families can also benefit from an awareness of specific facilitators and barriers to communication.Department of Counseling Psychology and Guidance Services
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Blackwelder, Reid B. "Integrative Approaches to Patients with Cancer." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/6987.
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Vittatoe, Danielle S., and L. Lee Glenn. "Effects of Telemonitoring in Cancer Patients." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/7473.
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Motenko, Jill Swartwout. "The Spiritual Quests of Cancer Patients." Antioch University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1329323769.
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Allen, Denise M. "Future orientation of adolescent cancer patients /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487758178237076.
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Rattican, Debra. "Symptom Clusters in Lung Cancer Patients." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/352.
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SYMPTOM CLUSTERS IN LUNG CANCER PATIENTS By Debra Rattican, PhD, RN A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Debra E. Lyon, PhD. Professor and Chair Family and Community Health Nursing The purpose of the study was to examine selected relationships among symptoms common to individuals with lung cancer. The specific aims were: 1) To examine the relationship between the symptoms of dyspnea and anxiety in patients with lung cancer. 2) To examine the relationships among the symptoms of dyspnea, anxiety, and symptom cluster components (depressive symptoms, fatigue, pain) in patients with lung cancer. 3) To examine the correlation between functional ability and quality of life in patients with lung cancer. 4) To explore the relationships among the symptoms of dyspnea, anxiety, and symptom cluster components (depressive symptoms, fatigue, pain) in patients with lung cancer and patients’ functional ability. 5) To explore the relationships among the symptoms of dyspnea, anxiety, and symptom cluster components (depressive symptoms, fatigue, pain) in patients with lung cancer and patients’ quality of life. Data were gathered through online survey and analyzed using descriptive, correlation, principal component analysis, exploratory factor analysis, and forward stepwise regression techniques. A strong positive correlation was found between dyspnea and anxiety (both anxiety in general and anxiety at the time the survey was completed. While results of this study cannot provide conclusive evidence of the existence of a symptom cluster composed of depressive symptoms, fatigue, and pain, the results are consistent with other studies in this area. Significant positive correlations among these three symptoms indicate that this is a possible symptom cluster experienced by lung cancer patients in general. This study provides preliminary data on how these symptoms are related and how they affect functional ability, or the ability to perform routine activities of daily living (ADLS) and instrumental activities of daily living (IADLS), and quality of life in patients with lung cancer. Further study is needed on to better understand the symptom experience of these individuals in order to develop robust interventions targeting effective symptom management.
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Pietrucin-Materek, Marta. "Patients' preferences for cancer follow-up." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=223919.
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Introduction As a result of the growing and ageing population in developed countries, improved cancer detection and advances in cancer treatments, there are more people living with cancer for longer. The rising number of cancer survivors and increasing demand for oncology services, has sparked interest in alternative ways of delivering cancer follow-up care. Although a number of alternative cancer follow-up strategies have been developed, information about the relative importance of different characteristics of follow-up and how people trade between these characteristics is still limited. Aims and objectives The overall aim of the thesis was to understand what characteristics (called attributes and levels) of cancer follow-up services are important to survivors of cutaneous melanoma, breast, prostate and colorectal cancer; whether people make trade-offs between these characteristics; and whether survivors of different cancers with different personal characteristics express different preferences for cancer follow-up care. The aim was met by a number of objectives: •To conduct a review of the literature to gather information about characteristics of follow-up that are important to people. • To conduct semi-structured qualitative interviews with cancer survivors living in North East Scotland, to determine their views of current care and preferences for future cancer follow-up. • Based on the findings from the literature and semi-structured interviews, to determine characteristics (attributes and levels) of cancer follow-up services for inclusion in a discrete choice experiment. • To develop and carry out a discrete choice experiment to establish the relative importance of a number of attributes of cancer follow-up amongst cancer survivors treated and followed up for cutaneous melanoma, breast, prostate and colorectal cancer.
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Dasch, Kimberly B. "Affective differentiation in breast cancer patients." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 70 p, 2009. http://proquest.umi.com/pqdweb?did=1885670961&sid=7&Fmt=2&clientId=8331&RQT=309&VName=PQD.
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Yates, Susan. "Struggling to care : the experience of women caring for partners dying of cancer." Thesis, Lancaster University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444637.
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Dockery, Kimberley. "Living with Uncertainty: The Impact on Breast Cancer Survivors and Their Intimate Partners." NSUWorks, 2014. http://nsuworks.nova.edu/shss_dft_etd/3.
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This study explored the lived experiences of breast cancer survivors and their intimate partners. The research was informed by a social constructionist framework and phenomenological method of inquiry. While the body of literature on the physical, psychological, and social health of breast cancer survivors is growing, only a few studies have focused solely on the lived experience of survivorship and the uncertainty of recurrence. This study sought to explore the construction of meaning in the couples' context and experiences of surviving breast cancer. The present study examined how breast cancer survivors make meaning of their survivorship in context of living with the fear of recurrence. The researcher investigated the patients' and their intimate partners' experiences of survivorship to gain a better understanding of how their lived experiences affect their relationships to themselves and their significant other and how they cope with the uncertainty of recurrence. The study provided clinical implications for medical family therapists working with breast cancer survivors for couples managing the challenges with survivorship and uncertainty.