Relevant bibliographies by topics / Particle Inhalation Technology

Academic literature on the topic 'Particle Inhalation Technology'

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Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Particle Inhalation Technology"

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Dorato, Michael A., and Ronald K. Wolff. "Inhalation Exposure Technology, Dosimetry, and Regulatory Issues." Toxicologic Pathology 19, no. 4_part_1 (November 1991): 373–83. http://dx.doi.org/10.1177/0192623391019004-106.

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Inhalation toxicology technology has provided the scientific community with important advances in studies of inhaled toxicants. These advances include new and more efficient exposure systems (e.g., flow-past nose-only exposure systems), and improved approaches to inhalation chamber environmental control (e.g., temperature, humidity, air quality). Practical problems and approaches to testing and operating inhalation exposure systems and the advantages and disadvantages of the major inhalation exposure types (e.g., whole-body, nose-only) are discussed. Important aspects of study design, such as high level particulate exposures resulting in large lung burdens (e.g., ≥2 mg/g of lung), slowed pulmonary clearance rates, and nonspecific toxicity are considered, along with practical issues of comparative dosimetry. Regulatory guidelines have continued to present challenges in designing and conducting acute, subchronic, and chronic inhalation studies. The important regulatory issue of performing acute inhalation toxicity studies at high aerosol concentrations and “respirable” particle size distribution is discussed.
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Varghese Vadakkan, Mithun, and G. S. Vinod Kumar. "Advancements in Devices and Particle Engineering in Dry Powder Inhalation Technology." Current Topics in Medicinal Chemistry 16, no. 18 (April 29, 2016): 1990–2008. http://dx.doi.org/10.2174/1568026616666160215154938.

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Nayak, Smita, Priyanka Ghugare, and Bhaskar Vaidhun. "EVALUATION OF AERODYNAMIC PARTICLE SIZE DISTRIBUTION OF DRUGS USED IN INHALATION THERAPY: A CONCISE REVIEW." International Journal of Research -GRANTHAALAYAH 8, no. 7 (August 1, 2020): 264–71. http://dx.doi.org/10.29121/granthaalayah.v8.i7.2020.579.

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Most of the inhalation products in the market use metered dose inhaler (MDI) technology or dry powder inhaler (DPI) technology. MDIs use propellant to deliver desired dose of liquid formulation in aerosol form. DPI contains active in fine particulate form embedded onto an inert carrier. In both cases, amount of drug dispensed from the device reaching the lungs is dependent upon drug product characteristics as well as formulation-device relationship. Hence, in addition to particle size, aerodynamic distribution of the drug upon delivery by the device plays an important role in determining amount of drug reaching the lungs. Therefore particle size characterization is an important tool in determining the extent of drug delivery from the metered dose inhaler. Aerodynamic particle size distribution is frequently determined by use of cascade impactors and data so generated is accepted by regulatory agencies as a tool for predicting efficacy of MDIs and DPIs. This review discusses principle and working of cascade impactors. Additionally, the review also examines the role of laser diffraction technique in estimating size of dispersed particles.
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Misik, Ondrej, Milan Maly, Ondrej Cejpek, and Frantisek Lizal. "Characterization of Aerosol Nebulized by Aerogen Solo Mesh Nebulizer." MATEC Web of Conferences 328 (2020): 01006. http://dx.doi.org/10.1051/matecconf/202032801006.

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Nebulizers are commonly used devices for inhalation treatment of various disorders. There are three main categories of medical nebulization technology: jet nebulizers, ultrasound nebulizer, and mesh nebulizer. The mesh nebulizers seem to be very promising since this technology should be able to produce aerosol with precisely determined particle size and is easy to use as well [1]. Aerosol generated from the mesh nebulizer Aerogen Solo was measured in this work. Particle size distribution with a mass median of aerodynamic diameter (MMAD) was determined by two different methods.
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Bell, David C., Lenore C. Rainey, and John B. Vander Sande. "High Resolution Microanalysis of Particles from the Human Lung." Microscopy and Microanalysis 5, S2 (August 1999): 400–401. http://dx.doi.org/10.1017/s1431927600015324.

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Every time we take a breath, we are inhaling the results of twentieth century combustion technology. Combustion processes generally produce a multitude of soot and other sub micron sized particulates. The human lungs, via the process of cilia movement expel most of these particles; others are broken down with the aid of macrophage agents. These macrophages absorb particles and incorporate the constitute elements into our bodies. These elements maybe expelled, or they may remain in the body and accumulate over time, as is the case with certain heavy metals. Limited prior research on ‘single-particle’ interaction with lung or bronchial tissue has been conducted. Related research has focused on the statistical significance of soot inhalation on the lung tissue of rodents and primates [1]. Using the methods of single particle examination, founded by previous research into single particle source allocation [2], the examination particles of from human lung and bronchial tissues was performed.Research on the particle characterization shown here is based on the application of an innovative method developed at MIT, which utilized high resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM) coupled with electron energy loss spectroscopy (EELS) and energy dispersive X-ray analysis (EDX).
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Pacławski, Adam, Jakub Szlęk, Renata Jachowicz, Stefano Giovagnoli, Barbara Wiśniowska, Sebastian Polak, Natalia Czub, and Aleksander Mendyk. "Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems." Applied Sciences 10, no. 20 (October 13, 2020): 7109. http://dx.doi.org/10.3390/app10207109.

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Spray drying is a single step process in which solutions or dispersions are converted into dry particles. It is widely used in pharmaceutical technology to produce inhalable particles. Dry particle behavior during inhalation, described as the emitted dose (ED) and fine particle fraction (FPF), is determined in vitro by standardized procedures. A large number of factors influencing the spray drying process and particle interaction makes it difficult to predict the final product properties in advance. This work presents the development of predictive models based on experimental data obtained by aerodynamic assessment of respirable dry powders. Developed models were tested according to the 10-fold cross-validation procedure and yielded good predictive ability. Both models were characterized by normalized root-mean-square error (NRMSE) below 8.50% and coefficient of determination (R2) above 0.90. Moreover, models were analyzed to establish a relationship between spray drying process parameters and the final product quality measures. Presented work describes the strategy of implementing the evolutionary algorithms in empirical model’s development. Obtained models can be applied as an expert system during pharmaceutical formulation development. The models have the potential for product optimization and a knowledge extraction to improve final quality of the drug.
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Suric Mihic, Marija, Ivan Beslic, Silvije Davila, Gordana Marovic, Luka Pavelić, and Jasminka Sencar. "ESTIMATION OF AIRBORNE 106RU ACTIVITY CONCENTRATION FROM TOTAL BETA ACTIVITY OF PM10 PARTICLE FRACTIONS." Radiation Protection Dosimetry 189, no. 4 (May 2020): 497–504. http://dx.doi.org/10.1093/rpd/ncaa067.

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Abstract Airborne radioruthenium, as a result of an accidental release, presents a risk for occupational and public exposure. In fall 2017, a detection of 106Ru was reported by the European atmospheric radioactive contamination monitoring networks. We investigated the daily specific total beta activity of PM10 particle fractions samples. The presented method enables indirect determination of airborne 106Ru activity concentration from total beta activity, in case 106Ru was confirmed as single excess radiological pollutant. This allows for daily measurements and time-resolved 106Ru activity concentration data. We estimated the indicative committed effective dose due to 106Ru inhalation for the Croatian population during the exposure period. Although the estimated dose value of ~169.7 nSv, for ~6-d duration of ruthenium air pollution, was very low, it was ~40 times higher than the value for Hinh from inhalation of other radionuclides (90Sr + 137Cs + 40K + 7Be).
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El-Ansary, A., and S. Al-Daihan. "On the Toxicity of Therapeutically Used Nanoparticles: An Overview." Journal of Toxicology 2009 (2009): 1–9. http://dx.doi.org/10.1155/2009/754810.

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Human beings have been exposed to airborne nanosized particles throughout their evolutionary stages, and such exposures have increased dramatically over the last century. The rapidly developing field of nanotechnology will result in new sources of this exposure, through inhalation, ingestion, and injection. Although nanomaterials are currently being widely used in modern technology, there is a serious lack of information concerning the human health and environmental implications of manufactured nanomaterials. Since these are relatively new particles, it is necessary to investigate their toxicological behavior. The objective of this review was to trace the cellular response to nanosized particle exposure. Therapeutic application of selected nanoparticles together with their range of toxic doses was also reviewed. Effect of therapeutically used nanoparticles on cell membrane, mitochondrial function, prooxidant/antioxidant status, enzyme leakage, DNA, and other biochemical endpoints was elucidated. This paper highlights the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts.
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Lavorini, Federico, Christer Janson, Fulvio Braido, Georgios Stratelis, and Anders Løkke. "What to consider before prescribing inhaled medications: a pragmatic approach for evaluating the current inhaler landscape." Therapeutic Advances in Respiratory Disease 13 (January 2019): 175346661988453. http://dx.doi.org/10.1177/1753466619884532.

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Inhaled therapies are the cornerstone of treatment in asthma and chronic obstructive pulmonary disease, and there are a multitude of devices available. There is, however, a distinct lack of evidence-based guidance for healthcare providers on how to choose an appropriate inhaler. This review aims to summarise recent updates on topics related to inhaler choice, and to offer practical considerations for healthcare providers regarding currently marketed devices. The importance of choosing the right inhaler for the right patient is discussed, and the relative merits of dry powder inhalers, pressurised metered dose inhalers, breath-actuated pressurised metered dose inhalers, spacers and soft mist inhalers are considered. Compiling the latest studies in the devices therapy area, this review focuses on the most common types of handling errors, as well as the comparative rates of incorrect inhalation technique between devices. The impact of device-specific handling errors on inhaler performance is also discussed, and the characteristics that can impair optimal drug delivery, such as inhalation flow rate, inhalation volume and particle size, are compared between devices. The impact of patient perceptions, behaviours and problems with inhalation technique is analysed, and the need for appropriate patient education is also highlighted. The continued development of technology in inhaler design and the need to standardise study assessment, endpoints and patient populations are identified as future research needs. The reviews of this paper are available via the supplemental material section.
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Xiao, Kai, Qingyue Wang, Yichun Lin, Weiqian Wang, Senlin Lu, and Shinich Yonemochi. "Approval Research for Carcinogen Humic-Like Substances (HULIS) Emitted from Residential Coal Combustion in High Lung Cancer Incidence Areas of China." Processes 9, no. 7 (July 20, 2021): 1254. http://dx.doi.org/10.3390/pr9071254.

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The incidence and mortality rate of lung cancer is the highest in Xuanwei County, Yunnan Province, China. The mechanisms of the high lung incidence remain unclear, necessitating further study. However, the particle size distribution characteristics of HULIS emitted from residential coal combustion (RCC) have not been studied in Xuanwei. In this study, six kinds of residential coal were collected. Size-resolved particles emitted from the coal were sampled by using a burning system, which was simulated according to RCC made in our laboratory. Organic carbon (OC), elemental carbon (EC), water-soluble inorganic ion, water-soluble potentially toxic metals (WSPTMs), water-soluble organic carbon (WSOC), and HULIS-C (referred to as HULIS containing carbon contents) in the different size-segregated particulate matter (PM) samples were determined for health risk assessments by inhalation of PM. In our study, the ratio of HULIS-Cx to WSOCx values in RCC particles were 32.73–63.76% (average 53.85 ± 12.12%) for PM2.0 and 33.91–82.67% (average 57.06 ± 17.32%) for PM2.0~7.0, respectively. The carcinogenic risks of WSPTMs for both children and adults exceeded the acceptable level (1 × 10−6, indicating that we should pay more attention to these WSPTMs). Exploring the HULIS content and particle size distribution of the particulate matter produced by household coal combustion provides a new perspective and evidence for revealing the high incidence of lung cancer in Xuanwei, China.
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Dissertations / Theses on the topic "Particle Inhalation Technology"

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Sih, Roderick Peng Tze Chemical Sciences &amp Engineering Faculty of Engineering UNSW. "New process development of dense gas technology for the processing of pharmaceuticals." Publisher:University of New South Wales. Chemical Sciences & Engineering, 2008. http://handle.unsw.edu.au/1959.4/41257.

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Drug re-engineering is an effective method for engineering existing products in alternative dosage forms and with enhanced pharmacokinetics. Insulin for the management of diabetic symptoms is an ideal candidate for re-engineering. Current subcutaneous therapy results in low patient compliance and is ineffective in meeting the physiological need for post-prandial insulin. Implementation of dose titration for more efficient blood-glucose management is also inconvenient and uncomfortable. Inhaled insulin is presented as a superior alternative to current therapy. The lungs offer excellent access to the circulatory system. Aerosols suspended in inspired air may deposit on lung epithelia and be available for systemic absorption. To evade the defense mechanism of the human respiratory tract, particle sizes have traditionally been minimized to achieve necessary aerosol performance. Recent developments indicate that more efficient performance augmentation may also be achieved by decreasing the bulk density of powders and modifying surface characteristics. Light and fluffy powders with rough surfaces experience much higher drag forces within an airstream. The Atomized Rapid Injection for Solvent Extraction (ARISE) process is a unique precipitation platform devised by incorporating a rapid injection technique for energetic solution delivery into supercritical fluid (SCF) media to effect recovery of previously dissolved pharmaceutical compounds. The quasi-instantaneous delivery of solutions alleviates the drawbacks of the use of capillary nozzles or micro-orifices, gradual elution and mixing controlled precipitation kinetics in existing SCF precipitation techniques. Most importantly, the energetic release of solution into SCF media effects supersaturation over a much larger spatial volume and promotes the homogeneous precipitation of low bulk density powders. ARISE processed insulin powders displayed characteristics that were highly influenced by anti-solvent conditions and powders of different qualities were obtained as a function of anti-solvent pressures. At lower anti-solvent pressures, powders of narrow particle size distribution were achieved, an indication of homogeneous supersaturation levels within processing. Span, the index of size distribution was as low as 0.991. At higher anti-solvent pressures, supersaturation rates were increased while mixing efficiencies decreased, resulting in powders of wider size distribution, and powder bulk densities as low as 0.01 g/ml. Low bulk density insulin displayed in-vitro respirable fractions as high as 78%.
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Velaga, Sitaram P. "Preparation of Pharmaceutical Powders using Supercritical Fluid Technology : Pharmaceutical Applications and Physicochemical Characterisation of Powders." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4006.

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Books on the topic "Particle Inhalation Technology"

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Wang, Chiu-sen. Inhaled Particles, Volume 5 (Interface Science and Technology). Academic Press, 2005.

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Wang, Chiu-sen. Inhaled Particles, Volume 5 (Interface Science and Technology). Academic Press, 2005.

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Book chapters on the topic "Particle Inhalation Technology"

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Mitchell, Jolyon. "Aerodynamic Particle Size Testing." In Pharmaceutical Inhalation Aerosol Technology, 541–87. Third edition. | Boca Raton, Florida : CRC Press, [2019] |: CRC Press, 2019. http://dx.doi.org/10.1201/9780429055201-24.

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Lechuga-Ballesteros, David, Susan Hoe, and Benjamin W. Maynor. "Particle Engineering Technology for Inhaled Therapies." In Pharmaceutical Inhalation Aerosol Technology, 349–61. Third edition. | Boca Raton, Florida : CRC Press, [2019] |: CRC Press, 2019. http://dx.doi.org/10.1201/9780429055201-14.

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Tan, Bernice Mei Jin, Lai Wah Chan, and Paul Wan Sia Heng. "Milling and Blending: Producing the Right Particles and Blend Characteristics for Dry Powder Inhalation." In Pharmaceutical Inhalation Aerosol Technology, 273–89. Third edition. | Boca Raton, Florida : CRC Press, [2019] |: CRC Press, 2019. http://dx.doi.org/10.1201/9780429055201-11.

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"Methods of Aerosol Particle Size Characterization." In Pharmaceutical Inhalation Aerosol Technology, 369–408. CRC Press, 2003. http://dx.doi.org/10.1201/9780203912898-16.

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Washington, Clive. "Particle Size Analysis in Inhalation Therapy." In Metered Dose Inhaler Technology, 117–46. CRC Press, 1997. http://dx.doi.org/10.1201/b14362-5.

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Hirota, Keiji, and Hiroshi Terada. "Particle-manufacturing technology-based inhalation therapy for pulmonary diseases." In Colloid and Interface Science in Pharmaceutical Research and Development, 103–19. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-444-62614-1.00005-3.

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"The Development of Large Porous Particles for Inhalation Drug Delivery." In Modified-Release Drug Delivery Technology, 915–26. CRC Press, 2002. http://dx.doi.org/10.1201/9780203910337-78.

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Conference papers on the topic "Particle Inhalation Technology"

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Z. B, Tong, Zheng B., Yang R. Y., Yu A. B, and Chan H.-K. "Numerical Study of Aerosolisation of Carrier based Dry Powder Inhalation Systems." In 5th Asian Particle Technology Symposium. Singapore: Research Publishing Services, 2012. http://dx.doi.org/10.3850/978-981-07-2518-1_092.

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Versteeg, Henk K., Graham K. Hargrave, Perry A. Genova, Robert C. Williams, Dan Deaton, and Prashant Kakade. "Design Optimisation of Novel Pharmaceutical Actuator Using Optical Diagnostics." In ASME 7th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2004. http://dx.doi.org/10.1115/esda2004-58173.

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Pharmaceutical metered dose inhalers (MDIs) are drug delivery devices that are designed to produce self-propelled aerosols for inhalation therapies. Conventional MDI actuators use configurations based on a “two-orifice-and-sump” design. This promotes partial expansion of the propellant as a pre-atomisation stage. The final aerosol contains large numbers of respirable particles (1–5μm), but the aerosol plume velocity tends to be very high (50–100m/s). The KOS Vortex Nozzle Assembly (VNA) is an innovative actuator concept, which enables a measure of control of plume velocity. The device utilises a combination of a vortex chamber and a Bernoulli horn to reduce the plume velocity whilst increasing the respirable fraction of drug particles. The aerosol generation process in all MDIs, including the KOS VNA, inevitably leads to a certain amount of internal and external drug deposition, which represents an inefficiency of the drug delivery technology that can threaten dose uniformity. This paper reports the findings of an experimental study using optical diagnostics to investigate the primary atomization mechanism and external drug deposition in the VNA. High-speed video imaging is used to document the developing aerosol plume in the near-orifice and mouthpiece regions as well as the flow regime inside the vortex chamber using transparent versions of the VNA manufactured by means of rapid prototyping. We consider how the improved understanding of the flow processes resulting from this study supports measurements of fine-particle fractions and mouthpiece deposition. We also discuss how this type of fundamental investigation using optical diagnostics can be used to drive design improvements to identify VNA geometries with improved aerosol properties and reduced external drug deposition.
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