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Relevant bibliographies by topics / Parkinsons disease

Academic literature on the topic 'Parkinsons disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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Journal articles on the topic "Parkinsons disease"

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Borozdenko, Denis A., Vladislava I. Bogorodova, Nina M. Kiseleva, and Vadim V. Negrebetsky. "Parkinson’s disease: epidemiology and pathogenesis." Medical Journal of the Russian Federation 27, no. 2 (July 23, 2021): 183–94. http://dx.doi.org/10.17816/0869-2106-2021-27-2-183-194.

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This review presents data on the etiology, epidemiology, and pathogenesis of Parkinsons disease from National Center for Biotechnology Information (NCBI), eLibrary, CyberLeninka, and from monographs and textbooks. The prevalence, classification, genetic variability, main pathogenetic links, and potential disease development mechanisms are described. Both classic Parkinsons disease and variable manifestations of parkinsonism are considered. The factors that contribute to disease progression and inhibit its development are described. The main hypotheses of the pathogenetic mechanisms of Parkinsons disease are presented. These are protein misfolding, mitochondrial dysfunction, impaired protein purification systems, neuroinflammation, and pathology of the gut-brain axis.

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Robottom, Bradley, and William Weiner. "Parkinsons Disease Dementia." Current Psychiatry Reviews 5, no. 3 (August 1, 2009): 218–25. http://dx.doi.org/10.2174/157340009788971128.

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Horne, Malcolm. "27. Parkinsons disease." Journal of Clinical Neuroscience 17, no. 12 (December 2010): 1618. http://dx.doi.org/10.1016/j.jocn.2010.07.028.

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Kidalov, Maksim B., and Elena V. Savchenko. "Methods for early diagnosis of Parkinson’s disease." Aspirantskiy Vestnik Povolzhiya 20, no. 1-2 (December 10, 2020): 62–67. http://dx.doi.org/10.17816/2072-2354.2020.20.1.62-67.

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Currently, the diagnosis of Parkinsons disease is carried out mainly on the ground of clinical picture. However, long before the development of motor disorders, a number of signs characteristic of parkinsonism can be detected. The review of the literature presents methods to detect non-motor disorders that can be considered as predictors of the disease and it also discusses the issue of the laboratory studies of specific biomarkers for early diagnosis. We suggested to use the combination of olfactory test and questionnaire about vegetative disorders as the most relevant solution for clinical practice. It is recommended to interpret the test data as a sign of extremely high probability of the development of clinical manifestations of Parkinsons disease, and, therefore, as a reason to start preventive therapy.

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Garcia-Arencibia, Moises, Concepcion Garcia, and Javier Fernandez-Ruiz. "Cannabinoids and Parkinsons Disease." CNS & Neurological Disorders - Drug Targets 8, no. 6 (December 1, 2009): 432–39. http://dx.doi.org/10.2174/187152709789824642.

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Adams Jr., James, Mei-Ling Chang, and Lori Klaidman. "Parkinsons Disease - Redox Mechanisms." Current Medicinal Chemistry 8, no. 7 (June 1, 2001): 809–14. http://dx.doi.org/10.2174/0929867013372995.

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Wersinger, Christophe, and Anita Sidhu. "Inflammation and Parkinsons Disease." Current Drug Target -Inflammation & Allergy 1, no. 3 (September 1, 2002): 221–42. http://dx.doi.org/10.2174/1568010023344580.

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Shrestha, Resha, Pranaya Shrestha, Pravesh Rajbhandari, Samir Acharya, and Basant Pant. "Deep Brain Stimulation of bilateral Subthalamic nucleus (STN) following pallidotomy with Parkinsons crisis: A case report." Nepal Journal of Neuroscience 15, no. 1 (May 28, 2018): 40–42. http://dx.doi.org/10.3126/njn.v15i1.20029.

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We present a case of 57 years old patient with Idiopathic Parkinsons disease(PD) who had right sided Globus PallidusInternus (GPi) lesioning or pallidotomy as surgical treatment modality of PD. However this patient went into Parkinsons crisis postoperatively which is a rare form of complication. We had to admit in critical care for two weeks before he gradually improved and reached to preoperative state. This patient finally underwent deep brain stimulation(DBS) of bilateral Subthalamic nucleus (STN) and he has improved in terms of Unified Parkinson’s Disease Rating Scale(UPDRS) score.Nepal Journal of Neuroscience 15:40-42, 2018

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Indrakshi, T., A. Aparna, H. Krishna, N. Aashul, and Dr Jitendra S. Rajawat. "Parkinsons Disease: Recent Advancement and Future Aspects." International Journal for Research in Applied Science and Engineering Technology 10, no. 10 (October 31, 2022): 1262–79. http://dx.doi.org/10.22214/ijraset.2022.47171.

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Abstract: A prevalent neurodegenerative condition known as Parkinson's disease (PD) is characterized by a movement disorder with bradykinesia, rest tremor, rigidity, and postural instability. The majority of contemporary PD treatments are predicated on restoring dopaminergic tone in the striatum; however, there are few effective choices available. These, however, do not change the course of the disease and do not address the dopamine-independent symptoms of PD, such as freezing gait, cognitive impairment, and other non-motor aspects of the condition, which frequently have the biggest effects on quality of life. Novel therapy approaches are developing as our understanding of Parkinson's disease pathophysiology increases. These include therapies that target PD symptoms while avoiding the unfavorable side effects associated with currently available therapies, as well as therapies that halt pathology, minimize neuronal loss, and moderate disease progression. This article discusses some promising approaches that are currently being researched in the laboratories or are in the clinical trial phase such as cell based therapies, gene therapy, neuronal therapy, infusion therapy, neuron regeneration and novel drug approaches, which can pose as the future for the treatment of Parkinson’s disease

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Krasakov, Igor V., Igor V. Litvinenko, Gennadiy G. Rodionov, Nataliya I. Davydova, and Sergey S. Aleksanin. "Role of short-chain fatty acids in the pathogenesis of Parkinson’s disease." Russian Military Medical Academy Reports 41, no. 4 (November 17, 2022): 439–44. http://dx.doi.org/10.17816/rmmar111854.

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Parkinsons disease is tightly related to enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids are the main metabolites produced by the gut bacteria fermentation of dietary fiber and are suggested to play a key role in gutbrain cross-talk. The article presents a review of the literature on the contribution of short-chain fatty acids to the pathogenesis of Parkinsons disease. Patients with Parkinsons disease have higher plasma concentrations of acetate, propionate, and butyrate than controls. These changes correlate with the severity of the clinical picture of Parkinsons disease, levels of pro-inflammatory gut bacteria and pro-inflammatory cytokines. The cause of these changes may be an over-population of the gut of Parkinsons disease patients with bacteria such as clostridia and ruminococci, leading to regulatory immune reactions, intestinal inflammation, increased permeability of the intestinal barrier, excessive intake primarily of propionate in the central nervous system, and activation of neuroinflammation. The importance of further study of the relationship between changes in gut metabiotic, its metabolome, and the immune system T-cell in patients with Parkinsons disease is demonstrated. Justified the study of blood plasma from patients with Parkinsons disease using gas chromatographymass spectrometry for the accurate, clinically relevant, assessment of the gutbrain crosstalk.

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More sources

Dissertations / Theses on the topic "Parkinsons disease"

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Smith, Sarah Jane. "Metacognitive awareness of everyday memory in Parkinsons Disease." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522983.

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Pesola, Lauren E. "Parkinson's Disease: Are There Differences Among Measured & Perceived Function Between Stages of Disease." Bowling Green State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1408758404.

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Oliveira, Jussara Almeida de. "Validação da versão brasileira da Escala de Equilíbrio e Marcha (GABS) e análise do risco de quedas em indivíduos com doença de Parkinson e sujeitos saudáveis." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-18122014-101553/.

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Os estudos realizados até o momento demonstram que os instrumentos descritos na literatura possuem pouca capacidade de identificar os indivíduos em risco de quedas e portanto, existe a necessidade do desenvolvimento de novos testes ou de uma bateria de testes para essa população. Este estudo teve como objetivo traduzir e validar a Escala de Equilíbrio e Marcha (GABS) para aplicação em pacientes com doença de Parkinson (DP), determinar as características clínicas que estariam associadas ao maior risco de quedas em pacientes com DP e sujeitos saudáveis e analisar a utilidade do teste de Estabilidade Postural para avaliar o risco de quedas nos pacientes com DP. Foram selecionados pacientes do Ambulatório de Distúrbios do Movimento (AEXP) do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, com diagnóstico de DP e controles saudáveis. Os participantes foram avaliados por meio da versão motora simplificada da UPDRS, escalas de HY, SE, FOGQ, FES-I, BBS e GABS. Fizeram parte do estudo 107 pacientes com DP e 80 controles e pode-se verificar que a versão brasileira da GABS mostrou ser válida e confiável, com ótima consistência interna e boa confiabilidade inter e intraexaminador. Além disso, obteve validade convergente consistente, com correlações boas com outros instrumentos que avaliam o mesmo conceito. Somado a esses resultados, a GABS teve boa acurácia, sensibilidade, especificidade, valor preditivo positivo e valor positivo negativo considerável. Quando a GABS foi comparada com a BBS, as duas escalas tiveram resultados semelhantes. Entretanto, a GABS mostrou ser uma escala mais completa que a BBS, pois avalia diversos aspectos relacionados ao risco de quedas, como a instabilidade postural, alterações na marcha, o freezing e o medo de quedas, mostrando ser um instrumento mais interessante de ser utilizado em futuros ensaios clínicos e estudos prospectivos de evolução clínica da doença. Com relação às quedas, o principal ambiente relacionado às quedas nos pacientes com DP foi o doméstico e a marcha a principal causa, já nos controles o principal local das quedas também foi o doméstico e a principal causa de quedas foram os obstáculos presentes no ambiente. Além disso, maior tempo de doença e maior medo de quedas foram os fatores que mais contribuíram para explicar as quedas da população com DP. O teste de Estabilidade Postural conseguiu diferenciar os indivíduos com DP que sofreram quedas dos que não sofreram quedas, obteve correlações significativas com outros instrumentos que avaliam o equilíbrio e teve boa confiabilidade interexaminador.
Most studies to date have shown that the instruments available for the assessment of fall risk are inadequate for the identification of vulnerable individuals. Therefore, new tests assessing fall risk are strongly needed. This study aimed to translate and validate the Gait and Balance Scale (GABS) for use in patients with Parkinson\'s disease (PD), describe the clinical characteristics of a sample of patients with PD and controls that are related to the fall risk and analyze the Postural Stability test and it validity for assessing fall risk in patients with PD. We selected 107 PD patients at the Movement Disorders Outpatient Clinic of the School of Medicine of Ribeirão Preto - Universidade de São Paulo (USP) and 80 healthy controls. Participants were evaluated using the simplified version of the UPDRS motor scale, HY, SE, FOGQ, FES-I, BBS, and GABS. The Brazilian version of the GABS showed to be valid and reliable, with excellent internal consistency and good test-retest reliability. Furthermore, satisfactory convergent validity with other instruments that assess the same construct was found. In addition to these results, the GABS had good accuracy, sensitivity, specificity, positive predictive value, and negative predictive value. When the GABS was compared with the BBS, the two scales had similar results. However, the GABS showed to be more complete and could analyze more aspects related to fall risk in PD, as postural instability, gait deficits, freezing and fear of falling. Among controls, most falls also occurred indoors, however, they were mostly related to environmental hazards, and not gait. Longer disease duration and greater fear of falling were the factors that most contributed to explain falls in the population with PD. The Postural Stability test is able to differentiate individuals with PD who had experienced falls from those who had not, had significant correlation with others balance instruments and had good interexaminer reliability.

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Phillips, Kaitlyn, Brooks B. Pond, Hannah Oakes, and David R. McWethy. "The Influence of Long-Term Ritalin Exposure in a Female Model of Parkinson's Disease." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/13.

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Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed disorder in children. Methylphenidate (MPH) or Ritalin, is a psychostimulant widely prescribed to treat ADHD from childhood to adulthood. Although patients take MPH for years, studies investigating long-term MPH use are lacking. Additionally, abuse of MPH is a growing problem in young adults. MPH blocks dopamine and norepinephrine transporters, which extends these neurotransmitters’ actions by preventing their reuptake from the cleft. Previous research has shown that long-term exposure to MPH causes dopamine-releasing neurons in the nigrostriatal pathway to become more susceptible to the Parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Here, the mechanism by which MPH sensitizes neurons to MPTP in a female model was investigated. The hypothesis was that oxidation of excess dopamine to a quinone causes neurons within this pathway to become more susceptible to MPTP. This dopamine quinone may be conjugated by the antioxidant glutathione (GSH); however, with an excess of dopamine and therefore quinones, GSH levels will become depleted. Without protection from GSH, quinones may lead to production of highly reactive free radicals, precipitating cell death. Estrogen is thought to be neuroprotective to MPTP, so it was further hypothesized that anestrus (low estrogen) females will show more dopamine cell loss, more quinone production, and more GSH depletion than proestrus (high estrogen) females. To test this hypothesis, MPTP-resistant adolescent female Swiss-Webster mice were divided into 3 treatment groups: saline (control), 1 mg/kg MPH (therapeutic dose), or 10 mg/kg (abusive dose). Within each group, mice were divided into proestrus and anestrus subgroups. All mice were injected twice daily with MPH or saline. After 12 weeks of injections followed by a 7 day washout period, half of each grouping received MPTP injections (4 x 20 mg/kg every 2 hours), while the other half received 4 injections of sterile saline. Mice were sacrificed either 3 or 7 days post-MPTP or saline injection. The substantia nigra and striatum of the nigrostriatal pathway that are affected by Parkinson’s disease were collected. Proestrus females in the saline group showed a significant (pmore dopamine quinone production (*p

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Maravic, Ksenija. "Risk Factors for Visual Hallucinations in Parkinsons Disease : Investigating the Continuum." Thesis, Oxford Brookes University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506074.

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The present work presents a series of studies investigating neuropsychological aspects of visual hallucinations (VHs) in Parkinson's Disease (PD) and high proneness to VHs in the normal population. The aim of the thesis is to investigate whether the same risk factors are implicated in both hallucinating PD patients and in high-prone individuals from the normal population, i.e. the continuum hypothesis of VHs. To this end, new instruments were designed to assess the nature of VHs in PD and to differentiate among , high and low hallucination-prone individuals. PD patients with and without VHs, agematched normal controls, and high and low-prone normal young individuals are assessed on visual memory and executive tests from the CANTAB test battery, alongside tests examining personality factors, sleep patterns, and demographic factors. The findings suggest that VHs in PD and hallucination-proneness in the normal population are both associated with a combination of different factors, particularly aspects of visual processing and sleep patterns. Results from the five studies are interpreted with the multifactorial models of VHs, suggesting that both VHs in PD and hallucinationproneness in the normal population stem from concurrent neuropsychological dysfunctions of several processing systems. However, a specific personality profile is predictive of high hallucination-proneness in the normal population, but not in PD patients. Therefore, two different models are proposed, arguing for similar, but not identical set of risk factors in hallucinating PD patients and in high-prone normal individuals.

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Koduri, Balaram. "Quantitative Correlation Analysis of Motor and Dysphonia Features of Parkinsons Disease." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801902/.

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The research reported here deals with the early characterization of Parkinson’s disease (PD), the second most common degenerative disease of the human motor system after Alzheimer’s. PD results from the death of dopaminergic neurons in the substantia nigra region of the brain. Its occurrence is highly correlated with the aging population whose numbers increase with the healthcare benefits of a longer life. Observation of motor control symptoms associated with PD, such as gait and speech analysis, is most often used to evaluate, detect, and diagnose PD. Since speech and some delicate motor functions have provided early detection signs of PD, reliable analysis of these features is a promising objective diagnostic technique for early intervention with any remedial measures. We implement and study here three PD diagnostic methods and their correlation between each other’s results and with the motor functions in subjects diagnosed with and without PD. One initial test documented well in the literature deals with feature analysis of voice during phonation to determine dysphonia measures. Features of the motor function of two fingers were extracted in tests titled “Motor function of alternating finger tapping on a computer keyboard” and “Motor function of the index and thumb finger tapping with an accelerometer”, that we objectively scripted. The voice dysphonia measures were extracted using various software packages like PRAAT, Wavesurfer, and Matlab. In the initial test, several robust feature selection algorithms were used to obtain an optimally selected subset of features. We were able to program distance classifiers, support vector machine (SVM), and hierarchical clustering discrimination approaches for the dichotomous identification of non-PD control subjects and people with Parkinson’s (PWP). Validation tests were implemented to verify the accuracy of the classification processes. We determined the extent of functional agreement between voice and motor functions by correlating test results.

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Pålhagen, Sven E. "Parkinson's disease and depression clinical and neurobiological studies /." Stockholm : Karolinska institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-610-1/.

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Linse, Katharina. "Entwicklung und Evaluation einer psychoedukativ-kognitiven Gruppenintervention bei depressiven Symptomen bei Morbus Parkinson." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-219750.

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Hintergrund: Das idiopatische Parkinson-Syndrom (IPS) ist die zweithäufigste neurode-generative Erkrankung nach Morbus Alzheimer. Bei über 60-Jährigen liegt die Prävalenz bei bis zu zwei Prozent. Die somatischen Symptome verursachen vielfältige Beeinträchtigungen der Grob- und Feinmotorik und damit der Alltagsaktivitäten, viele Patienten leiden zusätzlich unter neuropsychiatrischen Symptomen. Das prominenteste neuropathologische Korrelat des IPS ist der Untergang dopaminerger Neurone in der Substantia Nigra. Dessen Ursachen sind nicht vollständig bekannt. Mit der Dopaminsubstitution steht eine erfolgreiche, jedoch nur symptomatische Therapie der chronisch progredienten Erkrankung zur Verfügung. Epidemiologisch besteht ein bidirektionaler Zusammenhang zwischen dem IPS und depressiven Störungen. Bis zu 40% der IPS-Patienten leidet unter klinisch relevanten depressiven Symptomen (IPS-D). Einige von ihnen erfüllen nicht die gängigen Diagnosekriterien depressiver Störungen, leiden jedoch unter vergleichbaren Einschränkungen der Lebensqualität und des Funktionsniveaus. IPS-D ist ferner mit schnellerem Krankheitsprogress, höherer Angehörigenbelastung, Heimunterbringung und höheren sozioökonomischen Kosten assoziiert. In der Praxis ist von einer Untererkennung und -versorgung der IPS-D auszugehen. Die Spontanremissionsraten sind gering, auch bei Patienten unter antidepressiver medikamentöser Therapie bleibt häufig eine Restsymptomatik bestehen. Die pathogenetischen Mechanismen der IPS-D sind nur teilweise verstanden, es ist von einem komplexen Vulnerabilitäts-Stress-Modell mit neurobiologischen und psychosozialen Komponenten auszugehen. Ferner bestehen vermutlich Subtypen der IPS-D mit unterschiedlichen Ursachenkonstellationen und therapeutischen Bedürfnissen. Medikamentöse Interventionen sind weniger wirksam als bei primären depressiven Störungen. Psychosoziale Interventionen, speziell kognitive Verhaltenstherapie, sind ersten Studien zufolge eine vielversprechende Therapieoption. Die Zugangsbarrieren zu Psychotherapie sind jedoch relativ hoch. Das Ziel der vorliegenden Arbeit war die Entwicklung einer niederschwelligen, speziell auf die IPS-D zugeschnittenen psychoedukativen Gruppenintervention. Hierfür wurde didaktisch und inhaltlich auf edukative Patientenprogramme zum IPS sowie Techniken der Psychoedukation und kognitiven Verhaltenstherapie als am besten beforschten Psychotherapieverfahren primärer depressiver Störungen zurückgegriffen. Es wurde eine multi-modale, ressourcenaktivierende, neunwöchige Intervention konzipiert, in deren Rahmen Informationen vermittelt und praktische Übungen zur Krankheitsbewältigung durchgeführt werden. In einem zweiten Schritt sollte Durchführbarkeit, Akzeptanz und subjektive Nützlichkeit sowie die Wirksamkeit der entwickelten Intervention auf die IPS-D an einer Patien-tenstichprobe evaluiert werden. Es wurde postuliert, dass sich die Intervention als gut durchführ bar erweist, von den Patienten gut angenommen wird und dass die fremd- und selbstgeratete Depressivität, das Belastungserleben und subjektive psychische Wohlbefinden durch die Intervention gebessert werden. Forschungsmethoden: Zur Überprüfung der Hypothesen wurde eine unizentrische, raterverblindete Studie mit kontrollierter Randomisierung und Wartekontrollgruppe an einer Patientenstichprobe mit IPS-D durchgeführt. Es erfolgte eine randomisierte Zuweisung der Teilnehmer zu Kontroll- (KG) oder Interventionsgruppe (IG) nach entsprechend des Ergebnis der Montgomery-Åsberg Depression Rating Scale (MADRS) stratifizierten Paaren. Aufgrund von Rekrutierungsproblemen wurden Teilnehmer der KG später in die IG eingeschlossen. Insgesamt wurden 26 Patienten in die Studie eingeschlossen, fünf von ihnen brachen die Teilnahme ab oder wurden aufgrund von Verletzungen des Studienprotokolls ausgeschlossen, fünf nahmen sowohl an KG als auch IG teil. Somit konnten 26 Fälle unter Berücksichtigung der zweifach allokierten Patienten und 19 Patienten gemäß Studienprotokoll ausgewertet werden. Zur Evaluation des Programms kamen entsprechende Fragebögen zum Einsatz. Primäres Outcomemaß der Wirksamkeitsprüfung war die fremdgeratete Depressivität gemäß MADRS. Weiterhin wurden bei Studienbeginn, unmittelbar postinterventionell sowie nach weiteren sechs Monaten selbstgeratete Depressivität, Lebensqualität, Belastungserleben, subjektives Wohlbefinden, Funktionsniveau und somatische Parameter der Erkrankung erhoben. Zur Auswertung des mehrfaktoriellen Versuchsplans mit zwei Faktorstufen (Gruppen) und drei Messzeitpunkten mit abhängigen Stichproben und Stichprobenziehung mit Zurücklegen wurden unter anderem Varianzanalysen mit Messwiederholung und lineare kovarianzanalytische Modelle mit drei Prüffaktoren und Ausgangswertadjustierung erstellt. Ergebnisse: Die Intervention erwies sich als gut durchführbar und wurde durch die Pati-enten gut akzeptiert. Die Rücklaufquote der Evaluationsfragebögen war mit 90% gut. Die meisten Patienten bewerteten das Programm als anschaulich und verständlich, die orga-nisatorischen Rahmenbedingungen als gut und die Inhalte als „hilfreich“. Insbesondere der Austausch mit Gleichbetroffenen wurde positiv bewertet. Es zeigte sich eine ausreichende Konzentrationsfähigkeit und bis auf wenige Ausnahmen ein gutes Verständnis der vermittelten Inhalte. In der per Protokoll analysierten Stichprobe konnten keine signifikanten Interventionseffekte nachgewiesen werden. Für die laut Studienprotokoll ausgewerteten ersten zwei Interventionsdurchgänge zeigte sich im Verglich mit der KG eine mit d=1,1 starke Reduktion der gesamten sowie der rein psychischen depressiven Symptomatik (Gesamtstichprobe: d=0,2 bzw. d=0,6), welche jedoch nur für die erstgenannte Teilstichprobe und nur unter Auslassung der somatischen Symptome statistische Signifikanz erreichte. Mit 38,5% erreichte ein nahezu signifikant größerer Teil der IG der Gesamtstichprobe Remission (p=0,063), bei 69,2% war die psychische Symptomatik mindestens um zwei Punkte gebessert, was als Minimum klinischer Relevanz gesehen wird. Die Effekte konnten über den Katamnesezeitraum nicht aufrechterhalten werden. In KG und IG kam es zu unterschiedlich starken Veränderungen der einzelnen depressiven Symptome mit einer stärkeren Reduktion von Traurigkeit, Untätigkeit und Suizidgedanken in der IG. Als Moderatorvariable der Treatmentresponse wurde lediglich die Teilnahme an einem der drei Interventions-Durchgänge identifiziert. Es konnten keine Interventionseffekte auf die wei-teren erhobenen psychischen Parameter erreicht werden. Schlussfolgerungen: In Anbetracht der spärlichen Studienlage und des hohen Bedarfs hat diese Untersuchung einer niederschwelligen psychosozialen Intervention zur Besserung der IPS-D einen Beitrag zum Erkenntnisgewinn geleistet. Zum Zeitpunkt des Studienbeginns war noch keine, aktuell sind nur drei kontrollierte Studien dieser Art publiziert. Das untersuchte Gruppenprogramm hat sich als gut durchführbar und für die Patienten annehmbar und subjektiv hilfreich erwiesen. Leider konnten mit den gewählten Untersuchungsmethoden zusammenfassend keine signifikanten Interventionseffekte auf die IPS-D nachgewiesen werden. Dennoch wurde, je nach Analyseverfahren, eine mäßige bis starke Reduktion der depressiven Kernsymptomatik in der IG erreicht, welche im Vergleich zu anderen unkontrollierten und kontrollierten Studien im Gruppensetting als etwas gleichwertig einzuschätzen ist, im Vergleich zu Einzel-KVT jedoch als geringer. Es zeigte sich, dass die Gruppenzusammensetzung Auswirkungen auf den Erfolg der Intervention haben kann. Die Divergenz von fremdgerateter Depressivität, subjektiver Nützlichkeit und anderen Maßen psychischen Wohlbefindens weist darauf hin, dass durch die Intervention möglicherweise positive Veränderungsprozesse angestoßen, nicht aber abgeschlossen wurden. Die untersuchte Intervention kann nach leichter Modifizierung, insbesondere dem Einbezug von Angehörigen, eine hilfreiche Ergänzung im Behandlungsplan der IPS-D darstellen. Bei Persistenz der depressiven Symptomatik sollte jedoch individualisierte KVT und Pharmakotherapie zum Einsatz kommen. Es erscheint wichtig, ins Bewusstsein zu rücken, dass die IPS-D keine unabwendbare Begleiterscheinung des IPS sein muss. Neben weiterer Forschung zu psychosozialen Interventionen in verschiedenen Settings sollte die Abgrenzung verschiedener IPS-D-Subtypen mit Blick auf die Wahl verschiedener therapeutischer Strategien vorangetrieben werden. Dies gilt auch für die Wahl des optimalen Zeitpunktes, der Intensität und inhaltlichen Schwerpunktsetzung psychosozialer Interventionen wie der untersuchten.

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Zhao, Ming. "Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease." Stockholm : Unit Injury and Repair in the Nervous System, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-649-1/.

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Delfani, Kioumars. "Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-258-2.

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Books on the topic "Parkinsons disease"

1

1930-, Stern Gerald, ed. Parkinson's disease. Baltimore: Johns Hopkins University Press, 1990.

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S, Ebadi Manuchair, and Pfeiffer Ronald, eds. Parkinson's disease. Boca Raton: CRC Press, 2005.

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Tanya, Simuni, and Pahwa Rajesh, eds. Parkinson's disease. Oxford: Oxford University Press, 2008.

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Parkinson's disease. Westport, Conn: Greenwood Press, 2008.

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1917-, Yahr Melvin D., Bergmann Kenneth J, International Federation of Parkinson's Disease Foundations., and International Symposium on Parkinson's Disease (8th : 1985 : New York, N.Y.), eds. Parkinson's disease. New York: Raven Press, 1987.

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J, Willow Marianne, ed. Parkinson's disease: New research. Hauppauge, N.Y: Nova Science Publishers, 2005.

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The Parkinson's disease handbook. London: Sheldon, 1993.

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F, Hahn Timothy, and Werner Julian, eds. New research on Parkinson's disease. New York: Nova Science, 2008.

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Anthony, Kilmister C. A., and Parkinson's Disease Society, eds. Parkinson's disease. London: Macdonald Optima, 1991.

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P, Hammerstad John, and Gancher S. T, eds. Parkinson's disease. St. Louis: Mosby Year Book, 1992.

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Book chapters on the topic "Parkinsons disease"

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Tamma, Filippo. "Extrapyramidal Diseases: Parkinson’s Disease." In Prognosis of Neurological Diseases, 363–68. Milano: Springer Milan, 2015. http://dx.doi.org/10.1007/978-88-470-5755-5_28.

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Kenanidis, Eustathios, Andreas Leonidou, Michael Potoupnis, Eleftherios Tsiridis, Aristotelis Kourtis, and Richard P. Baker. "Neurologic Diseases: Parkinson’s Disease." In The Adult Hip - Master Case Series and Techniques, 327–37. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-64177-5_11.

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Weis, Serge, Michael Sonnberger, Andreas Dunzinger, Eva Voglmayr, Martin Aichholzer, Raimund Kleiser, and Peter Strasser. "Neurodegenerative Diseases: Parkinson Disease." In Imaging Brain Diseases, 1001–20. Vienna: Springer Vienna, 2019. http://dx.doi.org/10.1007/978-3-7091-1544-2_37.

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Huddleston, Daniel E., and Stewart A. Factor. "Parkinsonism-Hyperpyrexia Syndrome in Parkinson’s Disease." In Movement Disorder Emergencies, 29–41. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-60761-835-5_3.

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Factor, Stewart A., and Anthony Santiago. "Parkinsonism-Hyperpyrexia Syndrome in Parkinson’s Disease." In Movement Disorder Emergencies, 29–40. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-902-8:029.

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Huddleston, Daniel E., and Stewart A. Factor. "Parkinsonism-Hyperpyrexia Syndrome in Parkinson’s Disease." In Movement Disorder Emergencies, 77–93. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-75898-1_5.

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Stocchi, Fabrizio, Margherita Torti, Giovanni Palleschi, and Antonio Carbone. "Bladder Dysfunction in Parkinson's Disease and Other Parkinsonism." In Parkinson's Disease, 274–83. Oxford, UK: Blackwell Publishing Ltd., 2011. http://dx.doi.org/10.1002/9781444397970.ch25.

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Nallapuraju, Ananya, Chen Rui Ye, Prannaya Gupta, and Arthur Tay. "Analysing Gait Patterns of Parkinsons’ Disease Patients to Predict Freezing of Gait (FoG) Using Machine Learning Algorithms." In IRC-SET 2021, 269–81. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9869-9_21.

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Stamelou, Maria, and Kailash Bhatia. "Dementia in Parkinson’s Disease and Atypical Parkinsonism." In Movement Disorders in Dementias, 179–97. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6365-7_11.

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DeRight, Jonathan. "Parkinson’s Disease and Parkinson’s Disease Dementia." In Essential Neuropsychology: A Concise Handbook for Adult Practitioners, 231–43. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85372-3_33.

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Conference papers on the topic "Parkinsons disease"

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Winston, Sam E., Riley C. Dehmer, and Timothy A. Doughty. "Parkinsons Disease: Tremor Suppression With Wearable Device." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-70910.

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Abstract Parkinson’s Disease (PD) is a neurodegenerative disorder that affects nearly a million people in the United States. Hand tremors are a well-known symptom associated with PD and result in anxiety, frustration, and malnutrition. While there is no cure, several approaches attempt to treat the symptoms. Many are invasive, including the use of pharmaceuticals and surgery [1]. Noninvasive technologies are often cumbersome and do not address the conspicuous nature experiencing tremors in public. This study is motivated by design criteria established from previous research [2], with a goal of an affordable, purely mechanical solution. In both cases, human subject testing echoed lab tests in effective tremor reduction. The extension to a wearable device gives the user the ability to hold or handle any object, or no object, with a significant reduction in tremor. Two separate wearable devices were tested for effectiveness while the simulated user ‘held’ two different objects to simulate different applications. Biomechanical modeling of the human hand informed the development of an adjustable mechanical hand-tremor system for testing. Models of the devices and the hand-device interface were used to simulate the dynamic response of the coupled systems. Each device was secured to the mechanical hand-tremor system and harmonic stimulus and response data was collected over the range of typical tremor frequencies. The results demonstrate the versatility of both designs for reducing the oscillations associated with tremors. The Ratio of Reduction (RoR) was defined to compare the tremor amplitude of the hand-tremor system with and without the device. Both designs were considered effective for each object with a max RoR of 28.09 for Device A and a max RoR of 99.32 for Device B.

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Gandhi, Jinang, Aumkar Gadekar, Tania Rajabally, Preetida Vinayakray-Jani, and Dayanand Ambawade. "Detection of Parkinsons Disease Via a Multi-Modal Approach." In 2021 12th International Conference on Computing Communication and Networking Technologies (ICCCNT). IEEE, 2021. http://dx.doi.org/10.1109/icccnt51525.2021.9580135.

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Orphanidou, Natasa K., Abir Hussain, Robert Keight, Paulo Lishoa, Jade Hind, and Haya Al-Askar. "Predicting Freezing of Gait in Parkinsons Disease Patients Using Machine Learning." In 2018 IEEE Congress on Evolutionary Computation (CEC). IEEE, 2018. http://dx.doi.org/10.1109/cec.2018.8477909.

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Bachlin, Marc, Meir Plotnik, Daniel Roggen, Noit Inbar, Nir Giladi, Jeffrey Hausdorff, and Gerhard Troster. "Parkinsons disease patients perspective on context aware wearable technology for auditive assistance." In 3d International ICST Conference on Pervasive Computing Technologies for Healthcare. ICST, 2009. http://dx.doi.org/10.4108/icst.pervasivehealth2009.6001.

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Baby, M. Sneha, A. J. Saji, and C. Sathish Kumar. "Parkinsons disease classification using wavelet transform based feature extraction of gait data." In 2017 International Conference on Circuit ,Power and Computing Technologies (ICCPCT). IEEE, 2017. http://dx.doi.org/10.1109/iccpct.2017.8074230.

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Zhang, MingYa, Na Zhao, Yue Yu, YuQian Zhuang, QuanQiu Zhu, TianYuan Huang, and XianPing Tao. "A Simple Yet Effective Hand Pose Tremor Classification Algorithm To Diagnosis Parkinsons Disease." In 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2022. http://dx.doi.org/10.1109/bibm55620.2022.9995709.

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Vasquez-Correa, J. C., J. R. Orozco-Arroyave, and E. Noth. "Word accuracy and dynamic time warping to assess intelligibility deficits in patients with Parkinsons disease." In 2016 XXI Symposium on Signal Processing, Images and Artificial Vision (STSIVA). IEEE, 2016. http://dx.doi.org/10.1109/stsiva.2016.7743349.

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Wright, David, Kazuhiro Nakamura, Tetsuya Maeda, Keiichi Kutsuzawa, Kazuhito Miyawaki, and Ken Nagata. "Research and development of a portable device to quantify muscle tone in patients with Parkinsons disease." In 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2008. http://dx.doi.org/10.1109/iembs.2008.4649790.

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Hossain, Md Ali, Tania Akter Asa, Sheikh Muhammad Saiful Islam, Muhammad Sajjad Hussain, and Mohammad Ali Moni. "Identification of genetic association of Thyroid Cancer with Parkinsons disease, Osteoporosis, chronic heart failure, Chronic kidney disease, Type 1 diabetes and Type 2 diabetes." In 2019 5th International Conference on Advances in Electrical Engineering (ICAEE). IEEE, 2019. http://dx.doi.org/10.1109/icaee48663.2019.8975560.

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Cheng, Wei-Yi, Florian Lipsmeier, Alf Scotland, Andrew Creagh, Timothy Kilchenmann, Liping Jin, Jens Schjodt-Eriksen, et al. "Smartphone-based continuous mobility monitoring of Parkinsons disease patients reveals impacts of ambulatory bout length on gait features." In 2017 IEEE Life Sciences Conference (LSC). IEEE, 2017. http://dx.doi.org/10.1109/lsc.2017.8268169.

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Reports on the topic "Parkinsons disease"

1

Singh, Ruchi, Akhiya Nail, and Nirendra Kumar Rai. Effectiveness of Vitamin B12 Supplementation on cognitive, motor & mood instability of Parkinson’s disease patients on levodopa treatment :A Systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0066.

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Review question / Objective: The treatment of choice for patients of Parkinson's disease is levodopa. However, levodopa has been suggested to decrease Vit B12 level in these patients. Thus, the research question for this systematic review is whether vit B 12 supplementation in Parkinson's disease(PD) patients on treatment with levodopa improves vit B12 level effecting the Cognition, Motor functions and Mood instability among them in comparison to PD patients on levodopa treatment who are not supplemented with Vit B12. Condition being studied: Parkinson disease is the progressive degeneration of dopaminergic neurons present within the substantia nigra that can lead to altered movements along with the prevalence of cognitive and mood instability as a result of dopamine(neurotransmitter) deficiency. The most effective treatment for the Parkinson's disease is the administration of levodopa, a dopamine precursor . Long term treatment with levodopa causes an increase in homocysteine levels and tissue deficiency of vitamin B12 and folate may occur. Vitamin B12 supplementation is administered as after management regime, in Parkinson patient on levodopa treatment . This study aims to conduct a systematic review, of studies , randomized control trials investigating the ability of vitamin B12 supplementation to enhances the recovery/reduce the decline, if any, of the symptoms of cognitive, motor, mood impairments associated with Parkinson's disease patient on levodopa treatment.

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Wang, Xiao, Hong Shen, Yujie Liang, Yixin Wang, Meiqi Zhang, and Hongtao Ma. Effectiveness of Tango Intervention on Motor Symptoms in Patients with Parkinson's Disease: A Protocol for Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0009.

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Review question / Objective: Parkinson's disease (PD) is a degenerative neurological disease caused by the loss of dopaminergic neurons in the pars compacta of the substantia nigra of the brain, resulting in lesions in the basal ganglia. The main motor symptoms of PD include resting tremor, rigidity, akinesia or bradykinesia and postural instability. As an exercise intervention based on musical accompaniment, tango dance has shown positive effects on the rehabilitation of motor symptoms in PD patients in recently. In this study, we systematically reviewed the efficacy of tango intervention in alleviating the motor symptoms of patients with PD. Condition being studied: Parkinson. Information sources: The following electronic databases will be searched: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science Core collection, and China National Knowledge Infrastructure Database (CNKI) and WanFang Database.

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Trimble, Brian A. Alaska Native Parkinson's Disease Registry. Fort Belvoir, VA: Defense Technical Information Center, November 2008. http://dx.doi.org/10.21236/ada493391.

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Katz, Edward. Biomechanical Assessment of Parkinson's Disease. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.83.

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Beal, M. F. Oxidative Damage in Parkinson's Disease. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada434051.

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Tanner, Caroline M. Alaska Native Parkinson's Disease Registry. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada609026.

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Trimble, Brian A. Alaska Native Parkinson's Disease Registry. Fort Belvoir, VA: Defense Technical Information Center, June 2011. http://dx.doi.org/10.21236/ada609150.

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Trimble, Brian A. Alaska Native Parkinson's Disease Registry. Fort Belvoir, VA: Defense Technical Information Center, November 2010. http://dx.doi.org/10.21236/ada609645.

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Seroogy, Kim B., and David M. Yurek. Neuregulins, Neuroprotection and Parkinson's Disease. Fort Belvoir, VA: Defense Technical Information Center, December 2002. http://dx.doi.org/10.21236/ada415998.

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Beal, M. F. Oxidative Damage in Parkinson's Disease. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada416957.

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