Relevant bibliographies by topics / Paratuberculosis

Academic literature on the topic 'Paratuberculosis'

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Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "Paratuberculosis"

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Laranja-da-Fonseca, Luis Femando, Alexandre Azevedo Oliva, Christian Campos Pereira, and Marcos Veiga dos Santos. "Doença de Johne: uma doença emergente em rebanhos leiteiros brasileiros." Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP 3, no. 2 (July 1, 2000): 30–39. http://dx.doi.org/10.36440/recmvz.v3i2.3336.

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A Paratuberculose ou Doença de Johne é uma doença infecto-contagiosa, causada pelo Mycobacterium paratuberculosis, que se caracteriza por um processo inflamatório granulomatoso no intestino dos ruminantes domésticos e selvagens, determinando redução na digestibilidade dos alimentos, com consequente queda na produção de leite. Os animais infectados geralmente apresentam diarreia progressiva e perda de peso, Ainda que a literatura nacional apresente descrições da ocorrência de paratuberculose como casos isolados, não existem dados sobre a ocorrência da paratuberculose em rebanhos leiteiros no Brasil. Em estudo recente que avaliou a presença de anticorpos anti-M. paratuberculosis em rebanhos leiteiros do Estado de São Paulo, LARANJA-DA-FONSECA et al. (1999) identificaram que dos 403 animais amostrados, 153 (37,9%) apresentaram anticorpos anti-Mycobacterium paratuberculosis e, das 20 fazendas amostradas, 19 (95%) tiveram pelo menos um animal positivo, existindo assim a necessidade de levantamentos epidemiológicos da doença, afim de que se possa avaliar o real impacto da paratuberculose nos rebanhos brasileiros.
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Tamboli, Cyrus P. "A Hypothesis for Explaining the Geographical Distribution of Crohn’s Disease." Canadian Journal of Gastroenterology 10, no. 3 (1996): 173–77. http://dx.doi.org/10.1155/1996/319469.

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The etiology of Crohn’s disease (CD) remains unknown, although there is epidemiological evidence supporting an environmental influence. Recent molecular techniques, including polymerase chain reaction, have renewed interest in a possible etiological role ofMycobacterium paratuberculosis, which has been isolated from a number of CD patients. The organism causes a chronic enteritis in animals called paratuberculosis, a condition with many clinical and pathological similarities to CD. This review compares the epidemiology of paratuberculosis in animals with the epidemiology of CD in humans. There is considerable overlap of regions with high prevalences of paratuberculosis and CD. This finding adds support to the implication ofM paratuberculosisin the etiology of CD.
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Zavgorodniy, A. I., S. A. Pozmogova, N. V. Goncharova, M. V. Kalashnyk, and V. V. Bilushko. "The study of epizootic sera obtained from ruminant animals in complement fixation test (CFT) with the use of Paratuberculous antigen." Veterinary Medicine: inter-departmental subject scientific collection, no. 105 (August 7, 2019): 41–45. http://dx.doi.org/10.36016/vm-2019-105-8.

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The paper presents results of the study of epizootic blood sera in the complement fixation test (CFT) with paratuberculous antigen. Blood sera were sampled from the cattle and goats. The antigen was produced from the culture filtrate of Mycobacterium avium subspecies paratuberculosis (MAP) in the laboratory for tuberculosis study. The aim of the present study was to clarify the epizootic situation concerning Johne’s disease among the dairy cattle in different regions of Ukraine. To achieve this aim the blood sera from cattle and goats were collected from farms in different regions of Ukraine. Those sera samples were studied in the complement fixation test with the use of paratuberculous antigen that was produced from the culture filtrate of MAP. The above mentioned blood sera were collected from the cattle that had positive allergic reactions on the use of tuberculin (PPD) for mammals. Those animals belonged to the free from tuberculosis and paratuberulosis milk farms. The study of obtained samples of blood sera was conducted in the accordance with the methodological guidelines “Laboratory diagnostics of paratuberculosis” (shutter. NMR FEFU pr. No. 1, dated December 19, 2014). There were studied 1098 blood sera samples from cattle. In addition to this, investigation was conducted on 24 samples of blood sera from goats. As the result of conducted study it was found that 17 samples of blood sera contained specific antibodies against MAP (serum solution 1:10). These blood sera collected from the cattle belonging to 4 farms in Poltava, Donetsk and Khmelnitsky regions. Along with this it was obtained 9 uncertain results in compliment fixation test that was conducted between paratuberculous antigen (ACF) and blood sera from those 4 farms. The results of monitoring studies indicate that M. avium subsp. paratuberculosis pathogen circulates in studied farms. This can lead to the complication of the epizootic situation regarding paratuberculosis and contribute to the spreading of this pathogen to other free from MAP infection farms. There are no anti-paratuberculosis antibodies in blood serum from goats. It is necessary to conduct annual monitoring serological studies of productive dairy cattle and imported animals in order to clarify and control epizootic situation concerning paratuberculosis on the territory of Ukraine
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Rowan, Neil J., Scott J. MacGregor, John G. Anderson, Douglas Cameron, and Owen Farish. "Inactivation of Mycobacterium paratuberculosis by Pulsed Electric Fields." Applied and Environmental Microbiology 67, no. 6 (June 1, 2001): 2833–36. http://dx.doi.org/10.1128/aem.67.6.2833-2836.2001.

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ABSTRACT The influence of treatment temperature and pulsed electric fields (PEF) on the viability of Mycobacterium paratuberculosiscells suspended in 0.1% (wt/vol) peptone water and in sterilized cow's milk was assessed by direct viable counts and by transmission electron microscopy (TEM). PEF treatment at 50°C (2,500 pulses at 30 kV/cm) reduced the level of viable M. paratuberculosis cells by approximately 5.3 and 5.9 log10 CFU/ml in 0.1% peptone water and in cow's milk, respectively, while PEF treatment of M. paratuberculosisat lower temperatures resulted in less lethality. Heating alone at 50°C for 25 min or at 72°C for 25 s (extended high-temperature, short-time pasteurization) resulted in reductions ofM. paratuberculosis of approximately 0.01 and 2.4 log10 CFU/ml, respectively. TEM studies revealed that exposure to PEF treatment resulted in substantial damage at the cellular level to M. paratuberculosis.
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Konté, M. "La paratuberculose. Diagnostic d'un premier cas chez un bovin d'importation au Sénégal." Revue d’élevage et de médecine vétérinaire des pays tropicaux 41, no. 2 (February 1, 1988): 147–48. http://dx.doi.org/10.19182/remvt.8714.

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Le diagnostic de paratuberculose est porté pour la première fois au Sénégal sur un bovin importé de France. Les circonstances d’isolement de Mycobacterium paratuberculosis sont rapportées. Les particularités culturales du germe sont évoquées et discutées. L’auteur conclut en invoquant la nécessité d’appliquer les mesures de police sanitaire arrêtées en la matière.
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HRUSKA, K., M. BARTOS, P. KRALIK, and I. PAVLIK. "Mycobacterium avium subsp. paratuberculosisin powdered infant milk: paratuberculosis in cattle – the public health problem to be solved." Veterinární Medicína 50, No. 8 (March 28, 2012): 327–35. http://dx.doi.org/10.17221/5631-vetmed.

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Fifty one products of dried milk baby food purchased from 10 producers from seven countries available on the Czech market have been tested. IS900, the specific fragments for Mycobacterium avium subsp. paratuberculosis (MAP) have been detected using PCR in 25 samples (49.0 %) and fragment f57 by real time PCR in 18 samples (35.3%). These results correspond to the epidemiological situation in Europe and are not unexpected. Paratuberculosis in cattle was almost unknown in the Czech Republic until 1990. An increase in the number of cows with paratuberculosis found in slaughterhouses and the incidence of Crohn’s disease in the last decade is evident. The possible risk of MAP dead cells or bacterial structures in food is discussed in respect to autoimmune Crohn’s disease. The national programmes of paratuberculosis control and certification of paratuberculosis-free herds should be strongly supported to decrease the risk for children and other people under higher risk. Producers should use MAP free milk for baby food production on a voluntary basis.
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Coussens, Paul M. "Mycobacterium paratuberculosisand the bovine immune system." Animal Health Research Reviews 2, no. 2 (December 2001): 141–62. http://dx.doi.org/10.1079/ahrr200134.

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AbstractMycobacterium aviumsubspeciesparatuberculosis(M. paratuberculosis) is the causative agent of Johne’s disease, a deadly intestinal ailment of ruminants. Johne’s disease is of tremendous economic importance to the worldwide dairy industry, causing major losses due to reduced production and early culling of animals. A highly controversial but developing link between exposure toM. paratuberculosisand human Crohn’s disease in some individuals has led to the suggestion thatM. paratuberculosisis also a potential food safety concern. As with many other mycobacteria,M. paratuberculosisis exquisitely adapted to survival in the host, despite aggressive immune reactions to these organisms. One hallmark of mycobacteria, includingM. paratuberculosis, is their propensity to infect macrophages. Inside the macrophage,M. paratuberculosisinterferes with the maturation of the phagosome by an unknown mechanism, thereby evading the host’s normal first line of defense against bacterial pathogens. The host immune system begins a series of attacks againstM. paratuberculosis-infected macrophages, including the rapid deployment of activated γδ T cells, CD4+T cells and cytolytic CD8+T cells. These cells interact with the persistently infected macrophage and with each other through a complex network of cytokines and receptors. Despite these aggressive efforts to clear the infection,M. paratuberculosispersists and the constant struggle of the immune system leads to pronounced damage to the intestinal epithelial cells. Enhancing our ability to control this important and tenacious pathogen will require a deeper understanding of howM. paratuberculosisinterferes with macrophage action, the cell types involved in the immune response, the cytokines these cells use to communicate, and the host genetic factors that control the response to infection.
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Cocito, C., P. Gilot, M. Coene, M. de Kesel, P. Poupart, and P. Vannuffel. "Paratuberculosis." Clinical Microbiology Reviews 7, no. 3 (July 1994): 328–45. http://dx.doi.org/10.1128/cmr.7.3.328.

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Paratuberculosis (Johne's disease) is a chronic, wasting, widespread mycobacteriosis of ruminants. It involves extensive mycobacterial shedding, which accounts for the high contagiousness, and ends with a fatal enteritis. Decreases in weight, milk production, and fertility produce severe economic loss. The DNA of the etiological agent (Mycobacterium paratuberculosis) has a base composition (66 to 67% G+C) within the range of that of mycobacteria (62 to 70% G+C), a size (4.4 x 10(6) to 4.7 x 10(6) bp) larger than that of most pathogenic mycobacteria (2.0 x 10(6) to 4.2 x 10(6) bp), and a high relatedness (> 90%) to Mycobacterium avium DNA. However, the DNAs of the two organisms can be distinguished by restriction fragment length polymorphism analysis. M. paratuberculosis genes coding for a transposase, a cell wall-associated protein (P34), and two heat shock proteins have been cloned and sequenced. Nucleic acid probes (two of which are species specific) are used, after PCR amplification, for M. paratuberculosis identification in stools and milk. As in leprosy, with disease progression, cellular immune reactions decrease and humoral immune reactions increase. Cutaneous testing with sensitins, lymphocyte proliferation assays, and cytokine tests are used to monitor cellular immune reactions in paratuberculosis, but these tests lack specificity. Complement fixation, immunodiffusion, and enzymometric tests based on antibodies to M. paratuberculosis extracts, to mycobacterial antigen complex A36, to glycolipids, and to proteins help identify affected cattle but are not species specific. The carboxyl-terminal portion of the 34-kDa cell wall-associated A36 protein (P34) carries species-specific B-cell epitopes and is the basis for an enzyme-linked immunosorbent assay. Diagnostic tests for paratuberculosis are also used in Crohn's disease, a chronic human ileitis mimicking Johne's disease, in which isolates identified as M. paratuberculosis have been found.
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Cocito, C., P. Gilot, M. Coene, M. de Kesel, P. Poupart, and P. Vannuffel. "Paratuberculosis." Clinical Microbiology Reviews 7, no. 3 (1994): 328–45. http://dx.doi.org/10.1128/cmr.7.3.328-345.1994.

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Mota, Rinaldo A., Paulo V. Peixoto, Elise M. Yamasaki, Elizabeth S. de Medeiros, Mateus M. da Costa, Rodolfo M. Peixoto, and Marilene F. Brito. "Ocorrência de paratuberculose em búfalos (Bubalus bubalis) em Pernambuco." Pesquisa Veterinária Brasileira 30, no. 3 (March 2010): 237–42. http://dx.doi.org/10.1590/s0100-736x2010000300008.

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A paratuberculose (doença de Johne) é uma das doenças de maior importância econômica para ruminantes em vários países e pode representar uma ameaça ao desenvolvimento da pecuária brasileira. É uma doença infecto-contagiosa que provoca enterocolite granulomatosa crônica, incurável e de difícil controle, cujo agente é o Mycobacterium avium subsp. paratuberculosis (MAP). Descreve-se a ocorrência de paratuberculose em um rebanho de búfalos no Estado de Pernambuco, Brasil. Não foi encontrado registro, na literatura, da ocorrência de paratuberculose em búfalos no país. De 100 búfalos, cinco mostravam sinais clínicos característicos da doença. À necropsia de dois animais as lesões estavam restritas ao intestino delgado com evidente espessamento da mucosa, aumento de linfonodos mesentéricos e vasos linfáticos proeminentes e dilatados. À microscopia, observaram-se na mucosa do intestino, infiltrado inflamatório granulomatoso com numerosos macrófagos epitelióides e células gigantes de Langhans, além de bacilos álcool-ácido resistentes (BAAR) visualizados através da coloração de Ziehl-Neelsen (ZN). Nos linfonodos mesentéricos, havia espessamento da cápsula e marcada inflamação granulomatosa. O exame direto pela técnica de ZN para pesquisa do bacilo em esfregaços de fezes, raspado de mucosa intestinal e imprint de linfonodos mesentéricos resultou positivo. A PCR IS900 específico de linfonodo mesentérico e mucosa intestinal revelou amplificação de um fragmento de aproximadamente 110pb, confirmada pela comparação com outras sequências de M. avium subsp. paratuberculosis disponíveis no GenBank.
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Dissertations / Theses on the topic "Paratuberculosis"

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Chastel, Michaël Foucras Gilles. "Épidémiologie de la paratuberculose des ruminants conséquences sur les mesures de contrôle et de prévention /." [S.l.] : [s.n.], 2008. http://oatao.univ-toulouse.fr/2081/1/debouch_2081.pdf.

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Marcé, Clara. "Modelling the transmission of and effectiveness of control measures for Mycobacterium avium subsp. Paratuberculosis in dairy herds." Rennes 1, 2010. http://www.theses.fr/2010REN1S047.

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Paratuberculosis is a worldwide incurable disease of ruminants resulting in a decrease in milk production and slaughter value. The aim of this thesis was to evaluate the epidemiological and economic effectiveness of selected control programmes in infected dairy herds. A stochastic simulation model has been developed to represent both the population dynamics within a dairy herd and the transmission of Mycobacterium avium subsp. Paratuberculosis (Map). It has been coupled to an existing bioeconomic model. The spontaneous within-herd progression of Map infection after the introduction of one infected cattle in an initially susceptible herd was studied in the absence of control measure. The effect of within-herd contacts on Map spread in a persistently infected herd was investigated. The cost-effectiveness of test-and-cull strategies to control Map infection in dairy herds was assessed. Simulation outcomes put forward that, even when no control measure is implemented, fadeout can occur if less than two clinically affected animals are present. In persistently infected herds, the two main transmission routes are transmission via the environment of the farm and in utero transmission. Isolating calves from their herd mates during the first weeks of age has no significant impact on Map transmission. Limiting or delaying calf exposure to adult faeces and early culling of clinically affected adults are thus recommended to decrease Map prevalence in infected dairy herds. Systematic test-and-cull appears cost-effective if implemented from the day one infected cattle is introduced. The tool designed here is flexible and enables studying other control options within a dairy herd
La paratuberculose est une maladie incurable des ruminants entraînant une diminution de la production laitière et de la valeur de carcasse des animaux infectés. L'objectif de ma thèse est d'évaluer l'efficacité épidémiologique et économique d'actions de maîtrise en troupeaux bovins laitiers infectés. Un modèle de simulation stochastique représentant la dynamique de population d'un troupeau bovin laitier et la transmission indirecte de Mycobacterium avium subsp. Paratuberculosis (Map) a été, élaboré puis couplé à un simulateur bioéconomique existant. L'évolution spontanée de l'infection après I'introduction d'un animal infecté dans un troupeau initialement sensible est étudiée en l'absence d'action de maîtrise. L'effet de la structure de contact sur la transmission de Map est exploré. La rentabilité de stratégies de maîtrise de l'infection est évaluée. Une extinction de l'infection peut survenir lorsque moins de deux animaux cliniquement infectés sont présents en cinq ans, en l'absence d'action de maîtrise. Dans les troupeaux infectés persistants, la transmission in utero et via l'environnement contaminé sont les deux principales voies de transmission. Empêcher le contact précoce entre veaux n'a pas d'impact sur la transmission de Map. Il est recommandé de limiter ou retarder l'exposition des veaux aux fèces des adultes et de réformer rapidement les animaux cliniquement infectés pour réduire la prévalence de l'infection. L'utilisation de tests suivis de réformes mis en place systématiquement dès l'introduction d'un animal infecté semble rentable. L'outil développé ici est flexible et permettra d'étudier d'autres actions de maîtrise en troupeau laitier
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Matado, André Filipe Fernandes. "Seroprevalência de paratuberculose em ovinos e caprinos na região do Baixo Alentejo." Master's thesis, Universidade de Évora, 2011. http://hdl.handle.net/10174/15722.

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No presente trabalho verificámos se existia circulação do agente da paratuberculose nas explorações de pequenos ruminantes no distrito de Beja. Avaliou-se a variação da circulação do agente em função das raças, localização geográfica, coabitação com outras espécies e dimensão das explorações. O estudo consistiu na pesquisa serológica que incidiu em 27 explorações de regime semi-extensivo utilizando um teste ELISA em animais com idade superior a 2 anos. Foram analisadas 25 explorações de ovinos de aptidão carne e duas de caprinos. Foram rastreados no total 187 animais, 172 ovinos e 15 caprinos. A seroprevalência aparente de rebanho encontrada foi 14,8%, com intervalo de confiança 5,9 a 32,5%. Na estimativa da seroprevalência real de rebanho este valor sobe para 41,2%, com intervalo de confiança 16,4 a 90,2%. Apenas o factor coabitação dos rebanhos rastreados com rebanhos de bovinos revelou ter significância, podendo ser considerado factor de risco nos rebanhos de pequenos ruminantes; ABSTRACT: In this study we tested the circulation of Paratuberculosis in small ruminant flocks in the district of Beja. We evaluated the variation of the agent circulation with race, geographic location, cohabitation with other species and flocks size. The study consisted of a serological survey in 27 semi-extensive farms using an ELISA test in animals older than 2 years. We surveyed25 sheep flocks designed for meat production and two goats flocks. We screened a total of 187 animals, 172 sheep and 15 goats. The apparent herd prevalence found was 14.8% with a confidence limit from 5.9 to 32.5%. In estimating the real herd prevalence this figure rises to 41.2% with a confidence limit from 16.4 to 90.2%. Only the cohabitation flocks factor with cattle flocks seems to be significant and can be considered a risk factor in small ruminants.
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Beard, Philippa M. "Epidemiology and pathogenesis of paratuberculosis." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/29893.

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Investigations into three aspects of the epidemiology and pathogenesis of paratuberculosis were undertaken - infection of wildlife with Mycobacterium avium subsp paratuberculosis (M. a. paratuberculosis), the early host immune response mounted against organism, and the influence of host genotype on susceptibility to the disease. The pathology of natural rabbit paratuberculosis was investigated and described, with rabbits exhibiting either mild or severe lesions. The changes noted in the severely affected rabbits included the presence of giant cells containing over 50 nuclei and many acid fast bacteria. M. a. paratuberculosis was cultured from the faeces and urine of the naturally infected rabbits, revealing two possible routes of interspecies transmission of the organism. To investigate the impact of natural rabbit paratuberculosis on the disease in ruminant livestock, young calves were inoculated orally with a strain of M. a. paratuberculosis isolated from a naturally infected rabbit. After an incubation period of six months, the organism was recovered from the intestinal tissues of seven out of eight inoculated calves, with three of these calves also exhibiting pathological changes consistent with chronic paratuberculosis, suggesting that M.a.paratuberculosis from rabbits is capable of causing paratuberculosis in cattle. In a parallel experiment, two groups of rabbits were inoculated with either a bovine or leporine derived strain of M. a. paratuberculosis, but no evidence of infection was noted after a six month incubation period, suggesting that further, as yet unidentified factors, are involved in the pathogenesis of paratuberculosis in rabbits. A large survey in rural Scotland revealed M.a. paratuberculosis infection of 10 species of wildlife - fox, stoat, weasel, crow, rook, jackdaw, rat, wood mouse, hare, and badger. The investigations into wildlife reservoirs of M.a. paratuberculosis, the influence of host genes on susceptibility to the disease, and the role of gd T cells in the initial response to M.a. paratuberculosis infection provide new information on the epidemiology and pathogenesis of this disease, and may have a role to play in creating more effective control measures against paratuberculosis.
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Sergeant, Evan Stuart George. "Surveillance and risk assessment for ovine Johne's disease in Australia /." [St. Lucia, Qld.], 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17427.pdf.

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Okafor, Chika Chukwunonso. "Detection of Mycobacterium avium subsp. paratuberculosis IgG by a conductometric biosensor an aid in diagnosis of Johne's disease /." Diss., Connect to online resource - MSU authorized users, 2008.

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Nyange, John Frederick Charles. "Studies of paratuberculosis of red deer." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/30592.

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The mesenteric lymph nodes of 167 apparently healthy slaughtered red deer (18-24 m.o. old) from a herd in which several cases of paratuberculosis had occurred were examined by histopathology. An infection rate of 38% was found suggesting a high susceptibility of deer to paratuberculosis. Vaccination of all day-old calves with a standard bovine paratuberculosis vaccine stopped the occurrence of disease in yearlings and reduced significantly the rate (64/167 vs 32/201 p < < 0.001) and severity (41/64 vs 4/32 p < < 0.001) of infection as assessed by lymph node pathology of normal slaughter deer. The pathological lesions of paratuberculosis as observed in naturally and experimentally infected red deer, were inconsistent. Nevertheless, the specific lesions were basically similar to those of the disease in other ruminants, especially sheep and goats, where in severe cases, focal necrosis, mineralization and reactive fibrosis accompanied the granulomatous lesions. The clinical and pathological findings of avian tuberculosis in red deer, in a single natural case and in experimentally infected animals, were similar to those of paratuberculosis but they were more severe and widely disseminated into organs other than the intestines and related lymph nodes. The pathogeneses of paratuberculosis and avian tuberculosis in very young deer and very young sheep were shown to be similar by experimental infection. However the two infections progressed more rapidly and severely in deer than in sheep, with avian tuberculosis being more acute and severe than paratuberculosis. Fifty-four isolates of M. paratuberculosis from red deer were shown by cultural characterization to be similar to one another and to isolates of the organisms from a cow and a goat. Analysis of 14 of the isolates by SDS-PAGE and Western blotting did not distinguish them from one another or the bovine and caprine isolates. Despite many similarities in their polypeptide patterns, they were shown to differ from an atypical isolate of mycobacterium (M928), a commercial protoplasmic antigen (PPA-3) and M. avium isolates. Further analysis of six of the isolates by genomic DNA RE digestion with BamHI, PstI and EcoRI and hybridization with 32P-PCR279 (a DNA probe specific for M. ptbc), showed them to be homologous to both the bovine and caprine isolates when using BamHI and PstI, and only to the caprine isolate when using EcoRI. In conclusion, paratuberculosis of deer is basically similar to that of other ruminants, especially sheep and goats. However the short course and severity of disease in young animals is novel, contrasting with cattle, sheep and goats in which older animals become clinically affected.
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Pillars, Roxanne Bee. "Control strategies for Johne's disease in dairy cattle." Diss., Connect to online resource - MSU authorized users, 2008.

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Thesis (PH.D.)--Michigan State University. Large Animal Clinical Sciences, 2008.
Title from PDF t.p. (viewed on Aug. 28, 2009) Includes bibliographical references (p. 260-281). Also issued in print.
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Bush, Russell David. "The biological and financial impact of Ovine Johne's disease in Australia." Connect to full text, 2005. http://hdl.handle.net/2123/893.

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Thesis (Ph. D.)--University of Sydney, 2006.
Title from title screen (viewed 30 May 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Faculty of Veterinary Science. Degree awarded 2006; thesis submitted 2005. Includes bibliographical references. Also available in print form.
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Antognoli, Maria Celia. "Screening and diagnosis of paratuberculosis in young and adult dairy cattle." Access citation, abstract and download form; downloadable file 6.78 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131653.

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Books on the topic "Paratuberculosis"

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W, Sweeney Raymond, ed. Paratuberculosis (Johne's disease). Philadelphia, PA: W.B. Saunders Co., 1996.

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Behr, Marcel A., Karen Stevenson, and Vivek Kapur, eds. Paratuberculosis: organism, disease, control. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0000.

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Behr, M. A., and D. M. Collins, eds. Paratuberculosis: organism, disease, control. Wallingford: CABI, 2010. http://dx.doi.org/10.1079/9781845936136.0000.

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Behr, Marcel A. Paratuberculosis: Organism, disease, control. Wallingford, UK: CABI, 2010.

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International Colloquium on Paratuberculosis (7th 2002 Bilbao, Spain). Proceedings of the Seventh International Colloquium on Paratuberculosis. Madison, WI: International Association for Paratuberculosis, 2003.

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International Colloquium on Paratuberculosis (3rd 1991 Orlando, Fla.). Proceedings of the Third International Colloquium on Paratuberculosis: September 28 - October 2, 1991 : a meeting of the International Association for Paratuberculosis, the Orlando Marriott International Drive, Orlando, Florida, U.S.A. Providence, RI: The Association, 1992.

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International Colloquium on Paratuberculosis (5th 1996 Madison, Wis.). Proceedings of the fifth International Colloquium on Paratuberculosis, September 29-October 4, 1996: A meeting of the International Associaiton for Paratuberculosis, Madison, Wisconsin, U.S.A. Rehoboth, MA: International Association for Paratuberculosis, 1997.

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International Colloquium on Paratuberculosis (4th 1994 Cambridge, England). Proceedings of the Fourth International Colloquium on Paratuberculosis, July 17-July 21, 1994: A meeting of the International Association for Paratuberculosis, St. John's College, Cambridge, U.K. Rehoboth, MA: International Association for Paratuberculosis, 1995.

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International Colloquium on Paratuberculosis (8th 2005 Copenhagen, Denmark). Proceedings of the 8th International Colloquium on Paratuberculosis, August 14-18, 2005, Copenhagen, Denmark: A meeting of the International Association for Paratuberculosis, Inc. Madison, WI: International Association for Paratuberculosis, 2005.

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International Colloquium on Paratuberculosis (8th 2005 Copenhagen, Denmark). Proceedings of the 8th International Colloquium on Paratuberculosis, August 14-18, 2005, Copenhagen, Denmark: A meeting of the International Association for Paratuberculosis, Inc. Madison, WI: International Association for Paratuberculosis, 2005.

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Book chapters on the topic "Paratuberculosis"

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Gilmour, N. J. L. "Paratuberculosis." In The Management and Health of Farmed Deer, 113–19. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-1325-7_12.

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Anderson, Daniel C., and Harold M. McClure. "Paratuberculosis, Nonhuman Primates." In Nonhuman Primates I, 148–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84906-0_23.

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Nyange, J. F. C., N. J. L. Gilmour, D. Buxton, and Hugh W. Reid. "Paratuberculosis in Deer." In The Biology of Deer, 151. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2782-3_37.

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Fecteau, Marie-Eve. "Paratuberculosis in cattle." In Paratuberculosis: organism, disease, control, 149–59. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0149.

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Begg, Douglas, and Richard Whittington. "Paratuberculosis in sheep." In Paratuberculosis: organism, disease, control, 160–73. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0160.

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Lybeck, Kari R., Girum T. Tessema, Annette H. Kampen, Berit Djønne, and Angelika Agdestein. "Paratuberculosis in goats." In Paratuberculosis: organism, disease, control, 174–87. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0174.

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Donat, Karsten, Susanne Eisenberg, and Richard Whittington. "Paratuberculosis control measures." In Paratuberculosis: organism, disease, control, 346–64. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0346.

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Hussein, Mansour F. "Paratuberculosis (Johne’s Disease)." In Infectious Diseases of Dromedary Camels, 167–73. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79389-0_27.

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Duffy, Shannon C., and Marcel A. Behr. "Paratuberculosis and crohn's disease." In Paratuberculosis: organism, disease, control, 29–44. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0029.

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Juste, Ramón A., Joseba M. Garrido, Natalia Elguezabal, and Iker A. Sevilla. "Paratuberculosis vaccines and vaccination." In Paratuberculosis: organism, disease, control, 365–79. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0365.

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Conference papers on the topic "Paratuberculosis"

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Martcheva, M., Michail D. Todorov, and Christo I. Christov. "An Immuno-epidemiological Model of Paratuberculosis." In APPLICATION OF MATHEMATICS IN TECHNICAL AND NATURAL SCIENCES: 3rd International Conference—AMiTaNS'11. AIP, 2011. http://dx.doi.org/10.1063/1.3659918.

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Jiang, Xiu-Yun, Chun-Fang Wang, Fan-Li Zeng, Yu-Qing Hu, Xin-Yu Liu, Hao-Ran Ning, and Zhao-Yang He. "Cloning and Expression of 34KDa Protein Gene of Mycobacterium paratuberculosis in Escherichia coli." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515315.

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Liu, Xinyu, Chunfang Wang, Fanli Zeng, Lei Liu, Xiaoai Zhu, Yanhong Dong, Xiuyun Jiang, et al. "Notice of Retraction: Prokaryotic Expression and Analysis on the 22kDa Protein Gene of Mycobacterium paratuberculosis." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780043.

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Sanchez, M. P., T. Tribout, S. Fritz, R. Guatteo, C. Fourichon, L. Schibler, A. Delafosse, and D. Boichard. "165. A single step genetic evaluation including causal candidate SNPs for resistance to paratuberculosis in Holstein cattle." In World Congress on Genetics Applied to Livestock Production. The Netherlands: Wageningen Academic Publishers, 2022. http://dx.doi.org/10.3920/978-90-8686-940-4_165.

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Knobloch, Henri, Heike Köhler, Nicola Commander, Petra Reinhold, Claire Turner, Mark Chambers, Matteo Pardo, and Giorgio Sberveglieri. "Volatile Organic Compound (VOC) Analysis For Disease Detection: Proof Of Principle For Field Studies Detecting Paratuberculosis And Brucellosis." In OLFACTION AND ELECTRONIC NOSE: Proceedings of the 13th International Symposium on Olfaction and Electronic Nose. AIP, 2009. http://dx.doi.org/10.1063/1.3156505.

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Seehusen, F., and S. Scherrer. "Ein neuer S-Stamm von Mycobacterium avium subsp. paratuberculosis bei Ziegen in Graubünden – eine morphologische und molekulare Charakterisierung." In 62. Jahrestagung der Fachgruppe Pathologie der Deutschen Veterinärmedizinischen Gesellschaft. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688584.

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Usai, M. G., S. Casu, T. Sechi, M. G. Cancedda, D. Pintus, S. Salaris, G. Mulas, and A. Carta. "166. Genetic parameters and QTL mapping for antibody response to paratuberculosis in a natural infected flock of sheep." In World Congress on Genetics Applied to Livestock Production. The Netherlands: Wageningen Academic Publishers, 2022. http://dx.doi.org/10.3920/978-90-8686-940-4_166.

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Casu, S., M. G. Usai, T. Sechi, C. Maestrale, S. Miari, S. Salaris, C. Ligios, and A. Carta. "256. Functional and association analyses of sequence data in a region of OAR 20 associated to paratuberculosis in sheep." In World Congress on Genetics Applied to Livestock Production. The Netherlands: Wageningen Academic Publishers, 2022. http://dx.doi.org/10.3920/978-90-8686-940-4_256.

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Becher, Gunther, Roman Purkhart, Werner Schüler, Heike Köhler, and Petra Reinhold. "Highly specific differentiation ofmycobacterium avium subspec. paratuberculosis(MAP) in comparison to other mycobacteria using GC IMS-spectral analysis from headspace." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.oa3488.

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Reports on the topic "Paratuberculosis"

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Bonovska, Magdalena, Tanya Savova, Reneta Petrova, Violeta Valcheva, and Hristo Najdenski. Cases of Paratuberculosis in Deer in Bulgaria. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, March 2019. http://dx.doi.org/10.7546/crabs.2019.03.18.

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Bercovier, Herve, Michael Collins, Aliza Cohen, and Louis Levy. Recognition and Production of Specific Antigens of Mycobacterium Paratuberculosis. United States Department of Agriculture, October 1992. http://dx.doi.org/10.32747/1992.7600056.bard.

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Bercovier, Herve, Raul Barletta, and Shlomo Sela. Characterization and Immunogenicity of Mycobacterium paratuberculosis Secreted and Cellular Proteins. United States Department of Agriculture, January 1996. http://dx.doi.org/10.32747/1996.7573078.bard.

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Our long-term goal is to develop an efficient acellular vaccine against paratuberculosis based on protein antigen(s). A prerequisite to achieve this goal is to analyze and characterize Mycobacterium paratuberculosis (Mpt) secreted and cellular proteins eliciting a protective immune response. In the context of this general objective, we proposed to identify, clone, produce, and characterize: the Mpt 85B antigen and other Mpt immunoreactive secreted proteins, the Mpt L7/L12 ribosomal protein and other immunoreactive cellular proteins, Mpt protein determinants involved in invasion of epithelial cells, and Mpt protein antigens specifically expressed in macrophages. Paratuberculosis is still a very serious problem in Israel and in the USA. In the USA, a recent survey evaluated that 21.6% of the dairy herd were infected with Mpt resulting in 200-250 million dollars in annual losses. Very little is known on the virulence factors and on protective antigens of Mpt. At present, the only means of controlling this disease are culling or vaccination. The current vaccines do not allow a clear differentiation between infected and vaccinated animals. Our long-term goal is to develop an efficient acellular paratuberculosis vaccine based on Mpt protein antigen(s) compatible with diagnostic tests. To achieve this goal it is necessary to analyze and characterize secreted and cellular proteins candidate for such a vaccine. Representative Mpt libraries (shuttle plasmid and phage) were constructed and used to study Mpt genes and gene products described below and will be made available to other research groups. In addition, two approaches were performed which did not yield the expected results. Mav or Mpt DNA genes that confer upon Msg or E. coli the ability to invade and/or survive within HEp-2 cells were not identified. Likewise, we were unable to characterize the 34-39 kDa induced secreted proteins induced by stress factors due to technical difficulties inherent to the complexity of the media needed to support substantial M. pt growth. We identified, isolated, sequenced five Mpt proteins and expressed four of them as recombinant proteins that allowed the study of their immunological properties in sensitized mice. The AphC protein, found to be up regulated by low iron environment, and the SOD protein are both involved in protecting mycobacteria against damage and killing by reactive oxygen (Sod) and nitrogen (AhpC) intermediates, the main bactericidal mechanisms of phagocytic cells. SOD and L7/L12 ribosomal proteins are structural proteins constitutively expressed. 85B and CFP20 are both secreted proteins. SOD, L7/L12, 85B and CFP20 were shown to induce a Th1 response in immunized mice whereas AphC was shown by others to have a similar activity. These proteins did not interfere with the DTH reaction of naturally infected cows. Cellular immunity provides protection in mycobacterial infections, therefore molecules inducing cellular immunity and preferentially a Th1 pathway will be the best candidate for the development of an acellular vaccine. The proteins characterized in this grant that induce a cell-mediated immunity and seem compatible with diagnostic tests, are good candidates for the construction of a future acellular vaccine.
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Karcher, Elizabeth L., Donald C. Beitz, and Judith R. Stabel. Osteopontin Expression in Periparturient Dairy Cows Naturally Infected with Mycobacterium Avium Subsp. Paratuberculosis. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-843.

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Barkan, Daniel, Yung-Fu Chang, Patrick McDonough, Susan Fubini, and Robin Gleed. Identification of virulence-associated genes in Mycobacterium avium subsp. paratuberculosis by mutant-library construction. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7600046.bard.

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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture industry every year. Isolation of MAP from intestinal tissue and blood of Crohn's patients has lead to concern that it plays a potential pathogenic role in promoting human IDB including Crohn’s disease. There is great concern following the identification of the organism in animal products and shedding of the organism to the environment by subclinically infected animals. Little is known about the molecular basis for MAP virulence. The goal of the original proposed research was to identify MAP genes that are required for the critical stage of initial infection and colonization of ruminants’ intestine by MAP. We proposed to develop and use signature tag mutagenesis (STM) screen to find MAP genes that are specifically required for survival in ruminants upon experimental infection. This research projected was approved as one-year feasibility study to prove the ability of the research team to establish the animal model for mutant screening and alternative in-vitro cell systems. In Israel, neonatal goat kids were repeatedly inoculated with either one of the following organisms; MAP K-10 strain and three transposon mutants of K-10 which were produced and screened by the US PI. Six months after the commencement of inoculation we have necropsied the goats and taken multiple tissue samples from the jejunum, ileum and mesenteric lymph nodes. Both PCR and histopathology analysis indicated on efficient MAP colonization of all the inoculated animals. We have established several systems in the Israeli PI’s laboratory; these include using IS900 PCR for the identification of MAP and using HSP65-based PCR for the differentiation between MAV and MAP. We used Southern blot analysis for the differentiation among transposon mutants of K-10. In addition the Israeli PI has set up a panel of in-vitro screening systems for MAP mutants. These include assays to test adhesion, phagocytosis and survival of MAP to/within macrophages, assays that determine the rate of MAPinduced apoptosis of macrophages and MAP-induced NO production by macrophages, and assays testing the interference with T cell ã Interferon production and T cell proliferation by MAP infected macrophages (macrophage studies were done in BoMac and RAW cell lines, mouse peritoneal macrophages and bovine peripheral blood monocytes derived macrophages, respectively). All partners involved in this project feel that we are currently on track with this novel, highly challenging and ambitious research project. We have managed to establish the above described research systems that will clearly enable us to achieve the original proposed scientific objectives. We have proven ourselves as excellent collaborative groups with very high levels of complementary expertise. The Israeli groups were very fortunate to work with the US group and in a very short time period to master numerous techniques in the field of Mycobacterium research. The Israeli group has proven its ability to run this complicated animal model. This research, if continued, may elucidate new and basic aspects related to the pathogenesis MAP. In addition the work may identify new targets for vaccine and drug development. Considering the possibility that MAP might be a cause of human Crohn’s disease, better understanding of virulence mechanisms of this organism might also be of public health interest as well.
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Bradner, Laura K., Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Shedding of Mycobacterium avium subsp. paratuberculosis into Milk and Colostrum of Naturally Infected Dairy Cows over Complete Lactation Cycles. Ames (Iowa): Iowa State University, January 2013. http://dx.doi.org/10.31274/ans_air-180814-118.

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Karcher, Elizabeth L., Donald C. Beitz, and Judith R. Stabel. Parturition Invokes Changes in Peripheral Blood Mononuclear Cell Populations in Holstein Dairy Cows Naturally Infected with Mycobacterium Avium Subsp. Paratuberculosis. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-26.

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Osman, Mohamed, Judith Stabel, Jesse M. Hostetter, Daniel S. Nettleton, and Donald C. Beitz. Probiotic Lactobacillus acidophilus strain NP51® Curtails the Progression of Mycobacterium avium Subspecies paratuberculosis (MAP) Infection in Balb/c mice. Ames (Iowa): Iowa State University, January 2011. http://dx.doi.org/10.31274/ans_air-180814-66.

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Bradner, Laura, Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Optimization of Methods for the Detection of Mycobacterium avium subsp. paratuberculosis in Milk and Colostrum of Naturally Infected Dairy Cows. Ames (Iowa): Iowa State University, January 2012. http://dx.doi.org/10.31274/ans_air-180814-701.

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