Journal articles: 'Paper-based diagnostics'

1

Parolo, Claudio, and Arben Merkoçi. "Paper-based nanobiosensors for diagnostics." Chem. Soc. Rev. 42, no. 2 (2013): 450–57. http://dx.doi.org/10.1039/c2cs35255a.

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Parolo, Claudio, and Arben Merkoci. "ChemInform Abstract: Paper-Based Nanobiosensors for Diagnostics." ChemInform 44, no. 20 (April 25, 2013): no. http://dx.doi.org/10.1002/chin.201320276.

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Hu, Jie, ShuQi Wang, Lin Wang, Fei Li, Belinda Pingguan-Murphy, Tian Jian Lu, and Feng Xu. "Advances in paper-based point-of-care diagnostics." Biosensors and Bioelectronics 54 (April 2014): 585–97. http://dx.doi.org/10.1016/j.bios.2013.10.075.

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Määttänen, Anni, Daniela Fors, Shaoxia Wang, Dimitar Valtakari, Petri Ihalainen, and Jouko Peltonen. "Paper-based planar reaction arrays for printed diagnostics." Sensors and Actuators B: Chemical 160, no. 1 (December 2011): 1404–12. http://dx.doi.org/10.1016/j.snb.2011.09.086.

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Wu, Meirong, Qiongyu Lai, Qiang Ju, Lin Li, Hai-Dong Yu, and Wei Huang. "Paper-based fluorogenic devices for in vitro diagnostics." Biosensors and Bioelectronics 102 (April 2018): 256–66. http://dx.doi.org/10.1016/j.bios.2017.11.006.

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Linnes, Jacqueline C., Andy Fan, Natalia M. Rodriguez, Bertrand Lemieux, Huimin Kong, and Catherine M. Klapperich. "Paper-based molecular diagnostic for Chlamydia trachomatis." RSC Adv. 4, no. 80 (2014): 42245–51. http://dx.doi.org/10.1039/c4ra07911f.

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Singh, Saumitra, Mohd Rahil Hasan, Akshay Jain, Roberto Pilloton, and Jagriti Narang. "LFA: The Mysterious Paper-Based Biosensor: A Futuristic Overview." Chemosensors 11, no. 4 (April 19, 2023): 255. http://dx.doi.org/10.3390/chemosensors11040255.

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Lateral flow assay (LFA) is emerging as one of the most popular paper-based biosensors in the field of the diagnostic industry. LFA fills all the gaps between diagnosis and treatment as it provides beneficial qualities to users such as quick response, Point-of-care appeal, early detection, low cost, and effective and sensitive detections of various infectious diseases. These benefits increase LFA’s dependability for disease management because rapid and accurate disease diagnosis is a prerequisite for effective medication. Only 2% of overall healthcare expenditures, according to Roche Molecular Diagnostics, are spent on in vitro diagnostics, even though 60% of treatment choices are based on this data. To make LFA more innovative, futuristic plans have been outlined in many reports. Thus, this review reports on very knowledgeable literature discussing LFA and its development along with recent futuristic plans for LFA-based biosensors that cover all the novel features of the improvement of LFA. LFA might therefore pose a very significant economic success and have a significant influence on medical diagnosis.

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Choi, Jane Ru, Ruihua Tang, ShuQi Wang, Wan Abu Bakar Wan Abas, Belinda Pingguan-Murphy, and Feng Xu. "Paper-based sample-to-answer molecular diagnostic platform for point-of-care diagnostics." Biosensors and Bioelectronics 74 (December 2015): 427–39. http://dx.doi.org/10.1016/j.bios.2015.06.065.

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Syedmoradi, Leila, and Frank A. Gomez. "Paper-based point-of-care testing in disease diagnostics." Bioanalysis 9, no. 11 (June 2017): 841–43. http://dx.doi.org/10.4155/bio-2017-0080.

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Mao, Kang, Xiaocui Min, Hua Zhang, Kuankuan Zhang, Haorui Cao, Yongkun Guo, and Zhugen Yang. "Paper-based microfluidics for rapid diagnostics and drug delivery." Journal of Controlled Release 322 (June 2020): 187–99. http://dx.doi.org/10.1016/j.jconrel.2020.03.010.

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Xu, Gaolian, Debbie Nolder, Julien Reboud, Mary C. Oguike, Donelly A. van Schalkwyk, Colin J. Sutherland, and Jonathan M. Cooper. "Paper-Origami-Based Multiplexed Malaria Diagnostics from Whole Blood." Angewandte Chemie International Edition 55, no. 49 (August 24, 2016): 15250–53. http://dx.doi.org/10.1002/anie.201606060.

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Xu, Gaolian, Debbie Nolder, Julien Reboud, Mary C. Oguike, Donelly A. van Schalkwyk, Colin J. Sutherland, and Jonathan M. Cooper. "Paper-Origami-Based Multiplexed Malaria Diagnostics from Whole Blood." Angewandte Chemie 128, no. 49 (August 24, 2016): 15476–79. http://dx.doi.org/10.1002/ange.201606060.

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Lu, Zhengda, Elizabeth Rey, Sasank Vemulapati, Balaji Srinivasan, Saurabh Mehta, and David Erickson. "High-yield paper-based quantitative blood separation system." Lab on a Chip 18, no. 24 (2018): 3865–71. http://dx.doi.org/10.1039/c8lc00717a.

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Singh, Amrita, Darlin Lantigua, Akhil Meka, Shainlee Taing, Manjot Pandher, and Gulden Camci-Unal. "Paper-Based Sensors: Emerging Themes and Applications." Sensors 18, no. 9 (August 28, 2018): 2838. http://dx.doi.org/10.3390/s18092838.

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Paper is a versatile, flexible, porous, and eco-friendly substrate that is utilized in the fabrication of low-cost devices and biosensors for rapid detection of analytes of interest. Paper-based sensors provide affordable platforms for simple, accurate, and rapid detection of diseases, in addition to monitoring food quality, environmental and sun exposure, and detection of pathogens. Paper-based devices provide an inexpensive technology for fabrication of simple and portable diagnostic systems that can be immensely useful in resource-limited settings, such as in developing countries or austere environments, where fully-equipped facilities and highly trained medical staff are absent. In this work, we present the different types of paper that are currently utilized in fabrication of paper-based sensors, and common fabrication techniques ranging from wax printing to origami- and kirigami-based approaches. In addition, we present different detection techniques that are employed in paper-based sensors such as colorimetric, electrochemical, and fluorescence detection, chemiluminescence, and electrochemiluminescence, as well as their applications including disease diagnostics, cell cultures, monitoring sun exposure, and analysis of environmental reagents including pollutants. Furthermore, main advantages and disadvantages of different types of paper and future trends for paper-based sensors are discussed.

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Seth, Misago, and Joram Buza. "Multiplex paper-based designs for point-of-care (POC) diagnostics." International Journal of Research in Medical Sciences 5, no. 11 (October 27, 2017): 5052. http://dx.doi.org/10.18203/2320-6012.ijrms20174969.

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Background: Accurate and timely diagnosis is usually the first step towards appropriate disease management. In resource-limited settings, healthcare workers lack proper facilities to perform vital tests, and the diagnosis of disease is often determined by non-specific, physiological symptoms alone. Simple and rapid tests are needed as prerequisite tools for patient care and must conform to the criteria set out by the World Health Organization. To address the challenge of specific diagnosis for diseases that present with similar symptoms, multiplex diagnostic platforms must be designed.Methods: Simple designs for multiplexed paper-based diagnostic platforms were developed. Laser cutting and wax printing were used to create specific patterns on paper to guide the flow of sample and reagents towards reaction zones. Multi-arm and single strip multiplex platforms were designed and tested using Human Immunoglobulin G, Hepatitis B virus surface antigen (HBsAg), and Helicobacter pylori antigens.Results: All designs produced promising results with the lowest limit of detection for antigens being 30ng/ml for single strip designs.Conclusions: The use of glass fibre conjugate pad was found to be more sensitive compared wax-printed chromatography paper. Results from this study indicate great potential for further application in development of diagnostic low-cost paper-based diagnostic devices.

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Fiedoruk-Pogrebniak, Marta, and Robert Koncki. "LED&Paper-based analytical device for phosphatemia/calcemia diagnostics☆." Journal of Pharmaceutical and Biomedical Analysis 186 (July 2020): 113321. http://dx.doi.org/10.1016/j.jpba.2020.113321.

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Martinez, Andres W., Scott T. Phillips, George M. Whitesides, and Emanuel Carrilho. "Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices." Analytical Chemistry 82, no. 1 (January 2010): 3–10. http://dx.doi.org/10.1021/ac9013989.

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Dutta, Satarupa, Nilanjan Mandal, and Dipankar Bandyopadhyay. "Paper-based α- amylase detector for point-of-care diagnostics." Biosensors and Bioelectronics 78 (April 2016): 447–53. http://dx.doi.org/10.1016/j.bios.2015.11.075.

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Reinholt, S. J., A. Sonnenfeldt, A. Naik, M. W. Frey, and A. J. Baeumner. "Developing new materials for paper-based diagnostics using electrospun nanofibers." Analytical and Bioanalytical Chemistry 406, no. 14 (September 26, 2013): 3297–304. http://dx.doi.org/10.1007/s00216-013-7372-5.

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Smith, Suzanne, Jan G. Korvink, Dario Mager, and Kevin Land. "The potential of paper-based diagnostics to meet the ASSURED criteria." RSC Advances 8, no. 59 (2018): 34012–34. http://dx.doi.org/10.1039/c8ra06132g.

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V, Leya, Nilakshi Mazumder, Karthik G. Vaidya, Manasa K, Shilpa Sivashankar, and Kirubanandan Shanmugam. "Paper-Based Biosensor for Early Detection of Oral Cancer." BOHR International Journal of Cancer Research 1, no. 1 (2022): 1–8. http://dx.doi.org/10.54646/bijcr.001.

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The significance of paper-based biosensors for the early stage detection of oral cancer and their compatibility with affordable and low-cost diagnostics have been discussed in this article. Oral cancer is a major public health concern in India, and early-stage detection can be a great boon to the public. Among all the available methods for diagnosis, paper-based biosensors have proven to be very efficient in all aspects. It requires a very small volume of sample and very little time, and the process of detection is very simple. The diagnostic platform described here employs a hydrophobic material (wax) to pattern microfluidic channels on a hydrophilic substrate (paper) to detect the desired biomarker in saliva as biological fluid. Biomarker detection in saliva is advantageous because it is a noninvasive and potentially diagnostic sample. One of the primary benefits of using saliva in diagnosis is that sample collection is simple and noninvasive, significantly reducing the discomfort associated with blood collection and the privacy concerns associated with urine collection. The presence of biomarkers such as salivary cotinine and nitrite can be detected on a single paper-based analytical device, allowing for parallel quantification of the biomarkers. Calorimetric assays are used to analyze the biomarkers qualitatively, and ImageJ software is used to analyze the biomarkers quantitatively.

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Soni, Shruti, and Bhushan J. Toley. "Paper-based nucleic acid sample preparation for point-of-care diagnostics." Sensors and Actuators B: Chemical 355 (March 2022): 131272. http://dx.doi.org/10.1016/j.snb.2021.131272.

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Gerbers, Roman, Wilke Foellscher, Hong Chen, Constantine Anagnostopoulos, and Mohammad Faghri. "A new paper-based platform technology for point-of-care diagnostics." Lab Chip 14, no. 20 (August 15, 2014): 4042–49. http://dx.doi.org/10.1039/c4lc00786g.

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Li, Hua, and Andrew J. Steckl. "Paper Microfluidics for Point-of-Care Blood-Based Analysis and Diagnostics." Analytical Chemistry 91, no. 1 (September 26, 2018): 352–71. http://dx.doi.org/10.1021/acs.analchem.8b03636.

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Okabe, Shugo, Ryo Miyake, Kenji Sakamoto, Tomohiro Ishikawa, and Yuji Murakami. "MNM-3B-6 Paper Based Micro Analysis Chip for Clinical Diagnostics." Proceedings of the Symposium on Micro-Nano Science and Technology 2010.2 (2010): 167–68. http://dx.doi.org/10.1299/jsmemnm.2010.2.167.

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Kaur, Navjot, and Bhushan J. Toley. "Paper-based nucleic acid amplification tests for point-of-care diagnostics." Analyst 143, no. 10 (2018): 2213–34. http://dx.doi.org/10.1039/c7an01943b.

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Hristov, Delyan, Cristina Rodriguez-Quijada, Jose Gomez-Marquez, and Kimberly Hamad-Schifferli. "Designing Paper-Based Immunoassays for Biomedical Applications." Sensors 19, no. 3 (January 29, 2019): 554. http://dx.doi.org/10.3390/s19030554.

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Paper-based sensors and assays have been highly attractive for numerous biological applications, including rapid diagnostics and assays for disease detection, food safety, and clinical care. In particular, the paper immunoassay has helped drive many applications in global health due to its low cost and simplicity of operation. This review is aimed at examining the fundamentals of the technology, as well as different implementations of paper-based assays and discuss novel strategies for improving their sensitivity, performance, or enabling new capabilities. These innovations can be categorized into using unique nanoparticle materials and structures for detection via different techniques, novel biological species for recognizing biomarkers, or innovative device design and/or architecture.

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Afanasyev, V. I., F. V. Chernyshev, S. S. Kozlovsky, A. D. Melnik, G. V. Marinin, M. I. Mironov, A. S. Navolotsky, et al. "Development of the NPA based diagnostic complex in ITER." Journal of Instrumentation 17, no. 07 (July 1, 2022): C07001. http://dx.doi.org/10.1088/1748-0221/17/07/c07001.

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Abstract The NPA based diagnostic complex in ITER consists of four diagnostics: the neutral particle analyzers, the diamond neutral particle spectrometer, the gamma-ray spectrometer, and the neutron spectrometer. The diagnostics are located in equatorial port #11 and share the same vacuum channel. The present paper considers the physical basis of the diagnostic complex and its measurement capabilities in ITER. In addition, the design of the complex and the engineering solutions implemented to meet the ITER requirements are described.

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Motooka, Masanobu, and Shigeyasu Uno. "Improvement in Limit of Detection of Paper-Based Electrochemical Enzymatic Biogas Sensor." Proceedings 1, no. 8 (November 29, 2017): 762. http://dx.doi.org/10.3390/proceedings1080762.

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Smith, Suzanne, Jan G. Korvink, Dario Mager, and Kevin Land. "Correction: The potential of paper-based diagnostics to meet the ASSURED criteria." RSC Advances 8, no. 66 (2018): 37841. http://dx.doi.org/10.1039/c8ra90082e.

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Das, Debayan, Manaswini Masetty, and Aashish Priye. "Paper-Based Loop Mediated Isothermal Amplification (LAMP) Platforms: Integrating the Versatility of Paper Microfluidics with Accuracy of Nucleic Acid Amplification Tests." Chemosensors 11, no. 3 (February 28, 2023): 163. http://dx.doi.org/10.3390/chemosensors11030163.

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Paper-based diagnostics offer a promising alternative to traditional diagnostic methods for point-of-care use due to their low cost, ease of use, portability, rapid results, versatility, and low environmental impact. While paper-based serology tests in the form of lateral flow assays can provide rapid test results for past pathogen exposure, they currently lack the accuracy and sensitivity offered by molecular diagnostic tests such as the polymerase chain reaction (PCR). Loop-mediated isothermal amplification (LAMP)—an isothermal nucleic acid amplification test (NAAT)—provides PCR-like performance while simultaneously reducing the instrumentation and assay complexity associated with PCR. In this review, we discuss a newly emerging class of paper-based LAMP platforms that integrates the versatility of paper microfluidics with the accuracy of NAATs. Since its first adoption in 2015, we have discussed all paper-based LAMP platforms in terms of the paper substrates, reagent incorporation techniques, paper platform design, heating hardware, detection methods, and sensitivity and specificity of paper-based LAMP assays. We conclude by identifying the current challenges and future prospects of paper-based NAATs.

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Biswas, Sujay K., Subhamoy Chatterjee, Soumya Bandyopadhyay, Shantimoy Kar, Nirmal K. Som, Satadal Saha, and Suman Chakraborty. "Smartphone-Enabled Paper-Based Hemoglobin Sensor for Extreme Point-of-Care Diagnostics." ACS Sensors 6, no. 3 (February 26, 2021): 1077–85. http://dx.doi.org/10.1021/acssensors.0c02361.

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Kuswandi, Bambang, and Ali A. Ensafi. "Perspective—Paper-Based Biosensors: Trending Topic in Clinical Diagnostics Developments and Commercialization." Journal of The Electrochemical Society 167, no. 3 (November 20, 2019): 037509. http://dx.doi.org/10.1149/2.0092003jes.

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Mahato, Kuldeep, Ananya Srivastava, and Pranjal Chandra. "Paper based diagnostics for personalized health care: Emerging technologies and commercial aspects." Biosensors and Bioelectronics 96 (October 2017): 246–59. http://dx.doi.org/10.1016/j.bios.2017.05.001.

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Punjiya, Meera, Chung Hee Moon, Zimple Matharu, Hojatollah Rezaei Nejad, and Sameer Sonkusale. "A three-dimensional electrochemical paper-based analytical device for low-cost diagnostics." Analyst 143, no. 5 (2018): 1059–64. http://dx.doi.org/10.1039/c7an01837a.

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Shkilniak, Liudmyla, Waldemar Wójcik, Sergii Pavlov, Oleg Vlasenko, Tetiana Kanishyna, Irina Khomyuk, Oleh Bezverkhyi, Sofia Dembitska, Orken Mamyrbayev, and Aigul Iskakova. "EXPERT FUZZY SYSTEMS FOR EVALUATION OF INTENSITY OF REACTIVE EDEMA OF SOFT TISSUES IN PATIENTS WITH DIABETES." Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska 12, no. 3 (September 30, 2022): 59–63. http://dx.doi.org/10.35784/iapgos.3037.

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The paper analyzes the main areas of application of mathematical methods in medical diagnostics, formulates principles of diagnostics based on fuzzy logic; developed mathematical models and algorithms that formalize the process of making diagnostic decisions based on fuzzy logic with quantitative and qualitative parameters of the patient's condition; developed mathematical models of membership function. Mathematical models and algorithms have been developed that formalize the process of making diagnostic decisions based on fuzzy logic with quantitative and qualitative parameters of the patient's condition; developed mathematical models of membership functions, formalizing the representation of quantitative and qualitative parameters of the patient's condition in the form of fuzzy sets, used in models and algorithms for diagnosis and finding a diagnosis of assessing the intensity of reactive postoperative edema in patients of all study groups. An expert system was implemented for solving the problems of medical diagnosis based on fuzzy logic when assessing the intensity of reactive swelling of soft tissues, which develops in the postoperative period in patients of all study groups against the background of diabetes. The paper analyzes the main areas of application of mathematical methods in medical diagnostics, formulates the principles of diagnostics based on fuzzy logic.

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Chen, Z. S., Yong Min Yang, and L. J. Song. "Ontology-Based Representation of Heterogeneous Mechanical Systems Information for Integrated Diagnostics." Applied Mechanics and Materials 29-32 (August 2010): 258–63. http://dx.doi.org/10.4028/www.scientific.net/amm.29-32.258.

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During fault diagnostics of mechanical systems, information fusion methods were widely used to improve the reliability. However, diagnostic information comes from all life cycle of a mechanical device and they are always heterogeneous. Whereas heterogeneous information is difficult to be interconnecting, intercommunicating and inter-operating, so how to represent heterogeneous information is a key problem in integrated diagnostics. In this paper, a novel ontology-based representation method of heterogeneous diagnostic information is presented in detail. Firstly it introduces basic principles of ontology-based modeling. Then three methods of ontology-based information modeling are studied respectively. In the end an example of ontology-based modeling for a diesel engine is given.

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Jensen, Andrew D., and Anthony R. Lupo. "Using Enstrophy-Based Diagnostics in an Ensemble for Two Blocking Events." Advances in Meteorology 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/693859.

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Recent research has used enstrophy-based diagnostics to identify the development and dissipation stages of blocking events. These previous studies made use of reanalysis data sets in the calculations of the enstrophy-based diagnostics, such as the NCEP-NCAR reanalysis (2.5° × 2.5°) of geopotential height and horizontal winds. However, none of these studies has explored the use of the enstrophy-based diagnostics in weather or climate models with higher horizontal resolution. In this paper, the enstrophy-based diagnostics are used to analyze two blocking events, using data from the ERA-Interim reanalysis data set (0.75° × 0.75°) and also the Global Ensemble Forecast System (GEFS) (1° × 1°). The results of this work indicate that using an ensemble may be more effective than a single dynamical control forecast in evaluating the enstrophy-based diagnostic quantities, and that the results are similar to those obtained with coarser resolution.

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He, Guozhen, Tao Dong, Zhaochu Yang, Are Branstad, Lan Huang, and Zhuangde Jiang. "Point-of-care COPD diagnostics: biomarkers, sampling, paper-based analytical devices, and perspectives." Analyst 147, no. 7 (2022): 1273–93. http://dx.doi.org/10.1039/d1an01702k.

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COPD has become a major disease with great social and economic impacts. To enable point-of-care COPD diagnostics, paper-based analytical device is a promising candidate; however, it requires synergetic studies of biomarkers, biofluids, and sampling.

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Li, Zong An, Li Ya Hou, Wei Yi Zhang, and Li Zhu. "A New Fabrication Method for Paper-Based Microfluidic Device Used in Bio-Assay." Key Engineering Materials 562-565 (July 2013): 601–7. http://dx.doi.org/10.4028/www.scientific.net/kem.562-565.601.

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Paper-based microfluidic devices have a significant potential for low-cost diagnostics in the developing world. This study reported a simple fabrication method based on the digitallization of microfluidic technology for paper based microfluidic devices. Melted wax was jetted steadily with PZT actuated microfluidic pulse inertia driving system and pulled-forged glass micronozzle in the form of droplets. The wax melted into filter paper to form hydrophobic wall and different patterns for paper microfluidic devices were made. The influence of system parameters such as driving force, frequency, the fabrication process and the tip diameter of glass micronozzle on the wax line width was experimentally studied. 75 μm500 μm wax lines were achieved with the wax printing system. The paper microfluidic devices fabricated could lead the capillary action of black ink and the color change reaction of NaOH and phenolphthalein solution. Result showed that the wax printing system is simple structured and this method suggests a novel path to develop simple, inexpensive, and portable diagnostic assays.

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Gebretsadik, Tesfay, Tilahun Belayneh, Sosina Gebremichael, Wolfgang Linert, Madhu Thomas, and Tarekegn Berhanu. "Recent advances in and potential utilities of paper-based electrochemical sensors: beyond qualitative analysis." Analyst 144, no. 8 (2019): 2467–79. http://dx.doi.org/10.1039/c8an02463d.

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Paper based electrochemical sensors (PESs) are simple, low-cost, portable and disposable analytical sensing platforms that can be applied in clinical diagnostics, food quality control and environmental monitoring.

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Abbas, Hamza, Mubashar Ali, Hammas Ullah, and Ali Turab Jafry. "Actuation and Flow Control in Paper-Based Microfluidics by Varying Thickness of Storage Reservoir." MATEC Web of Conferences 381 (2023): 01010. http://dx.doi.org/10.1051/matecconf/202338101010.

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This paper discusses the potential of paper-based microfluidic devices for affordable diagnostics, and the importance of flow control. We have explored the variation of the width of paper, effect of 2D flow, and altering the surface wettability of paper to increase the resistance to fluid flow by physicochemical barriers. We used Whatman filter paper No. 40 and No. 1, mustard oil, and oleic acid, to examine the fluid flow due to capillary forces. Moreover, the effect of increase in thickness of the storage reservoir to decrease flow rate in the paper was also investigated. The experiments provide valuable insights into the behavior of fluid flow in porous media, and the findings have important applications in biomedical diagnostics and environmental monitoring.

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Yin, Kun, Xiong Ding, Ziyue Li, Maroun M. Sfeir, Enrique Ballesteros, and Changchun Liu. "Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2." Lab on a Chip 21, no. 14 (2021): 2730–37. http://dx.doi.org/10.1039/d1lc00293g.

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Nilghaz, Azadeh, Liyun Guan, Weirui Tan, and Wei Shen. "Advances of Paper-Based Microfluidics for Diagnostics—The Original Motivation and Current Status." ACS Sensors 1, no. 12 (December 12, 2016): 1382–93. http://dx.doi.org/10.1021/acssensors.6b00578.

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Miller, Eric A., Yara Jabbour Al Maalouf, and Hadley D. Sikes. "Design Principles for Enhancing Sensitivity in Paper-Based Diagnostics via Large-Volume Processing." Analytical Chemistry 90, no. 15 (June 20, 2018): 9472–79. http://dx.doi.org/10.1021/acs.analchem.8b02113.

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Kaur, Gurpreet, Monika Tomar, and Vinay Gupta. "A Simple Paper Based Microfluidic Electrochemical Biosensor for Point-of-Care Cholesterol Diagnostics." physica status solidi (a) 214, no. 12 (November 9, 2017): 1700468. http://dx.doi.org/10.1002/pssa.201700468.

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Chen, Yu, Guoqing Fu, Yael Zilberman, Weitong Ruan, Shideh Kabiri Ameri, Yu Shrike Zhang, Eric Miller, and Sameer R. Sonkusale. "Low cost smart phone diagnostics for food using paper-based colorimetric sensor arrays." Food Control 82 (December 2017): 227–32. http://dx.doi.org/10.1016/j.foodcont.2017.07.003.

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Jin, Chao, and Zunqing Zheng. "A Review on Homogeneous Charge Compression Ignition and Low Temperature Combustion by Optical Diagnostics." Journal of Chemistry 2015 (2015): 1–23. http://dx.doi.org/10.1155/2015/910348.

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Optical diagnostics is an effective method to understand the physical and chemical reaction processes in homogeneous charge compression ignition (HCCI) and low temperature combustion (LTC) modes. Based on optical diagnostics, the true process on mixing, combustion, and emissions can be seen directly. In this paper, the mixing process by port-injection and direct-injection are reviewed firstly. Then, the combustion chemical reaction mechanism is reviewed based on chemiluminescence, natural-luminosity, and laser diagnostics. After, the evolution of pollutant emissions measured by different laser diagnostic methods is reviewed and the measured species including NO, soot, UHC, and CO. Finally, a summary and the future directions on HCCI and LTC used optical diagnostics are presented.

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Kozitsin, Viacheslav, Iurii Katser, and Dmitry Lakontsev. "Online Forecasting and Anomaly Detection Based on the ARIMA Model." Applied Sciences 11, no. 7 (April 2, 2021): 3194. http://dx.doi.org/10.3390/app11073194.

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Real-time diagnostics of complex technical systems such as power plants are critical to keep the system in its working state. An ideal diagnostic system must detect any fault in advance and predict the future state of the technical system, so predictive algorithms are used in the diagnostics. This paper proposes a novel, computationally simple algorithm based on the Auto-Regressive Integrated Moving Average model to solve anomaly detection and forecasting problems. The good performance of the proposed algorithm was confirmed in numerous numerical experiments for both anomaly detection and forecasting problems. Moreover, a description of the Autoregressive Integrated Moving Average Fault Detection (ARIMAFD) library, which includes the proposed algorithms, is provided in this paper. The developed algorithm proves to be an efficient algorithm and can be applied to problems related to anomaly detection and technological parameter forecasting in real diagnostic systems.

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Reboud, Julien, Gaolian Xu, Alice Garrett, Moses Adriko, Zhugen Yang, Edridah M. Tukahebwa, Candia Rowell, and Jonathan M. Cooper. "Paper-based microfluidics for DNA diagnostics of malaria in low resource underserved rural communities." Proceedings of the National Academy of Sciences 116, no. 11 (February 19, 2019): 4834–42. http://dx.doi.org/10.1073/pnas.1812296116.

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Rapid, low-cost, species-specific diagnosis, based upon DNA testing, is becoming important in the treatment of patients with infectious diseases. Here, we demonstrate an innovation that uses origami to enable multiplexed, sensitive assays that rival polymerase chain reactions (PCR) laboratory assays and provide high-quality, fast precision diagnostics for malaria. The paper-based microfluidic technology proposed here combines vertical flow sample-processing steps, including paper folding for whole-blood sample preparation, with an isothermal amplification and a lateral flow detection, incorporating a simple visualization system. Studies were performed in village schools in Uganda with individual diagnoses being completed in <50 min (faster than the standard laboratory-based PCR). The tests, which enabled the diagnosis of malaria species in patients from a finger prick of whole blood, were both highly sensitive and specific, detecting malaria in 98% of infected individuals in a double-blind first-in-human study. Our method was more sensitive than other field-based, benchmark techniques, including optical microscopy and industry standard rapid immunodiagnostic tests, both performed by experienced local healthcare teams (which detected malaria in 86% and 83% of cases, respectively). All assays were independently validated using a real-time double-blinded reference PCR assay. We not only demonstrate that advanced, low-cost DNA-based sensors can be implemented in underserved communities at the point of need but also highlight the challenges associated with developing and implementing new diagnostic technologies in the field, without access to laboratories or infrastructure.

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Journal articles on the topic 'Paper-based diagnostics'

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