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Journal articles on the topic 'PAACS'

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Author: Grafiati

Published: 9 March 2023

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1

Bovey, J., F. Kooli, and W. Jones. "Preparation and characterization of Ti-pillared acid-activated clay catalysts." Clay Minerals 31, no. 4 (December 1996): 501–6. http://dx.doi.org/10.1180/claymin.1996.031.4.07.

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AbstractThe preparation and characterization of Ti-pillared acid-activated clays (designated Ti PAACs) and conventional Ti-pillared clays (designated Ti PILCs) are described. Preliminary catalytic results show that these materials possess remarkably enhanced abilities to catalyse the dehydration of pentanol compared with their Al counterparts (in excess of 200% in the case of the PILCs and up to 82% for the PAACs). These activities approach those previously reported for non-pillared acid-activated clays.

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2

Lazzari, Federica, Amedea Manfredi, Jenny Alongi, Raniero Mendichi, Fabio Ganazzoli, Giuseppina Raffaini, Paolo Ferruti, and Elisabetta Ranucci. "Self-Structuring in Water of Polyamidoamino Acids with Hydrophobic Side Chains Deriving from Natural α-Amino Acids." Polymers 10, no. 11 (November 13, 2018): 1261. http://dx.doi.org/10.3390/polym10111261.

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This paper reports on synthesis, acid-base properties and self-structuring in water of chiral polyamidoamino acids (PAACs) obtained by polyaddition of N,N′-methylenebisacrylamide with l-alanine, l-valine and l-leucine (M-l-Ala, M-l-Val, M-l-Leu) with potential for selective interactions with biomolecules. The polymers maintained the acid-base properties of amino acids. In water, the circular dichroism spectra of PAACs revealed pH-dependent structuring in the range 3–11 and in the wavelength interval 200–280 nm. Taking as reference the values at pH 3, the differential molar ellipticities were plotted in the pH interval 3–11. Sigmoidal curves were obtained presenting inflection points at pH 8.1, 6.8 and 7.3 for M-l-Ala, M-l-Val and M-l-Leu, respectively, corresponding to the amine half-ionization. Theoretical modeling showed that PAACs assumed stable folded conformations. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of protein hairpin motif. Oligomers with ten repeat units had simulated gyration radii consistent with the hydrodynamic radii obtained by dynamic light scattering.

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Ferruti, Federica, Jenny Alongi, Amedea Manfredi, Elisabetta Ranucci, and Paolo Ferruti. "Controlled Synthesis of Linear Polyamidoamino Acids." Polymers 11, no. 8 (August 8, 2019): 1324. http://dx.doi.org/10.3390/polym11081324.

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Polyamidoamino acids (PAACs) are synthetic polymers prepared by the polyaddition of bisacrylamides with natural α-amino acids, which in the process maintain both their chirality and their amphoteric nature. This polymerization process is slow, but has the merits of taking place in water and of neither involving protection/de-protection steps nor releasing by-products. However, it leads to polydisperse polymers and, using α-amino acids mixtures, random copolymers. This paper presents a step-by-step polyaddition process leading to homo- and copolymeric PAACs with controlled sequences and controlled molecular weights. It exploits the much different rates of the two Michael addition steps of NH2 of α-amino acids with acrylamides, and the low solubility in organic solvents of the α-amino acid addition products. As a proof of principle, the controlled synthesis of the PAAC from l-arginine and N,N′-methylenebisacrylamide was performed up to a monodisperse product with 11 monomeric units and molecular weight 1840. This synthetic procedure was also tested with l-alanine. All intermediates were isolated and characterized. Noticeably, all of them were α,ω-difunctionalized with either acrylamides or sec-amines and were, in fact, building blocks with potential for preparing complex macromolecular architectures. In a first instance, copolymers with controlled sequences of amidoamine- and amidoamino acid units were prepared.

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Van Essen, Caleb, Bruce C. Steffes, Keir Thelander, Beryl Akinyi, Hsin-Fang Li, and Margaret J. Tarpley. "Increasing and Retaining African Surgeons Working in Rural Hospitals: An Analysis of PAACS Surgeons with Twenty-Year Program Follow-Up." World Journal of Surgery 43, no. 1 (September 3, 2018): 75–86. http://dx.doi.org/10.1007/s00268-018-4781-9.

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5

Wang, Qilin, Shiyi Li, Zhibo Zheng, Zheng Chen, and Zhenhua Jiang. "Rapid and effective electrochemical strategy for the synthesis of PAASs/PAAKs electrochromic high-performance polymers." Solar Energy Materials and Solar Cells 254 (June 2023): 112256. http://dx.doi.org/10.1016/j.solmat.2023.112256.

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6

Wang, Shuo, Anne H. Blaes, Josef Coresh, Corinne E. Joshu, James S. Pankow, Bharat Thyagarajan, Elizabeth A. Platz, Weihua Guan, and Anna Prizment. "Abstract A022: Proteomic age acceleration associated with all-cause mortality in cancer survivors in the Atherosclerosis Risk in Communities (ARIC) Study. [R]." Cancer Research 83, no. 2_Supplement_1 (January 15, 2023): A022. http://dx.doi.org/10.1158/1538-7445.agca22-a022.

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Abstract Background: Longer lifespan and improved cancer treatment led to a rapid rise in the number of cancer survivors. However, many cancer survivors have physiological dysregulations at earlier chronological ages than those without cancer, suggesting that cancer survivors’ biological age is higher than their chronological age, i.e., they have accelerated aging. Cancer survivors’ biological age may be estimated by a novel proteomic aging clock (PAC). The deviation of PAC from chronological age is called proteomic age acceleration (PAA). To our knowledge, no studies examined whether PAA in cancer survivors is associated with increased all-cause mortality. We studied PAAs of two PACs – a newly created clock in ARIC (so called, “new” PAC) and the published 491-protein clock by Lehallier [2020] in relation to all-cause mortality in cancer survivors. Methods: ARIC is a prospective cohort of White and Black women and men, followed in 1987-2019. In 2011-13 (Visit 5), 5000 plasma proteins were measured using SomaScan, an aptamer-based assay. Using elastic net regression (alpha=0.5), we constructed a new PAC in a training set of two-thirds randomly selected cancer-free participants (N = 2466). This clock included 619 proteins and was internally validated in the remaining 1233 cancer-free participants (test set). We also computed Lehallier’s PAC using weights estimated in ARIC. We calculated PAA as residuals after regressing PAC on chronological age. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality per 1 standard deviation (SD, ~2.6 yrs for PAAs for both PACs) increase in PAA in 806 survivors of all cancer at Visit 5, and survivors of breast, prostate, and colorectal cancer. HRs were adjusted for chronological age, sex, race, center, education, BMI, smoking status, alcohol intake, eGFR, physical activity, time since cancer diagnosis, diabetes, and aspirin use. Results: 272 deaths were identified in 4963 person-yrs (median follow-up=6.98 yrs). In the test set, both PACs were correlated with chronological age [Pearson correlation coefficient (r): new PAC=0.75; Lehallier’s PAC=0.70] and with each other [r=0.89]. For both PACs, those with higher PAA tended to be White and have lower physical activity and a lower eGFR. Both PAAs were significantly associated with all-cause mortality in cancer survivors [per 1 SD: HR (95% CI): new PAC=1.42 (1.24-1.62); Lehallier’s PAC=1.40 (1.22-1.61)]. The HRs were not modified by sex or race. Both PAAs were significantly associated with all-cause mortality in 169 breast cancer survivors [HR: new PAC=1.54 (1.05-2.25); Lehallier’s PAC=1.72 (1.13-2.64)]. PAA of the new PAC was also associated with all-cause mortality in 78 colorectal cancer survivors [HR=1.96 (1.19-3.22)]. PAA for each PAC was not associated with all-cause mortality in 255 prostate cancer survivors. Conclusion: Proteomic aging clocks hold the promise as a potential biomarker for premature mortality in cancer survivors. Funding: NHLBI, NCI, NPCR Citation Format: Shuo Wang, Anne H. Blaes, Josef Coresh, Corinne E. Joshu, James S. Pankow, Bharat Thyagarajan, Elizabeth A. Platz, Weihua Guan, Anna Prizment. Proteomic age acceleration associated with all-cause mortality in cancer survivors in the Atherosclerosis Risk in Communities (ARIC) Study. [R] [abstract]. In: Proceedings of the AACR Special Conference: Aging and Cancer; 2022 Nov 17-20; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_1):Abstract nr A022.

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Egge, Mark, Zhen (Sean) Qian, and Amy Silbermann. "Effect of Fare Policies on Dwell Time." Transportation Research Record: Journal of the Transportation Research Board 2649, no. 1 (January 2017): 20–27. http://dx.doi.org/10.3141/2649-03.

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Bus fares may be collected when passengers board or immediately before they alight. Little work has been done to quantify the impacts of entry fare and exit fare policies on passenger stop delay, namely the dwell time. The Port Authority of Allegheny County (PAAC), Pennsylvania, is one of few mass transit systems to currently employ both entry fare and exit fare policies. PAAC’s alternating fare policy offers an ideal natural experiment for investigating the effect of fare collection policy on dwell time. PAAC automated passenger counter and automatic vehicle location data were analyzed to estimate dwell time under no fare collection and entry fare and exit fare policies. The study found that the choice of fare policy can significantly affect the dwell time associated with fare payment but also that the effect of fare policy varies with route characteristics. The findings suggest that a transit system that seeks to minimize the contribution of fare payment to total trip dwell time may be most effective by operating an entry fare policy on local routes with frequent stops and evenly distributed ridership and an exit fare policy on express and bus rapid transit routes with fewer stops and substantial passenger movements at major stops.

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8

Laslaz, Lionel. "Parcs nationaux et parcs naturels régionaux en France." Pour N° 243, no. 2 (May 19, 2022): 171–83. http://dx.doi.org/10.3917/pour.243.0171.

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9

Rogers, Lee F. "PACS." American Journal of Roentgenology 177, no. 3 (September 2001): 499. http://dx.doi.org/10.2214/ajr.177.3.1770499.

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10

Blosser, Jean L., and Annette Kratcoski. "PACs." Language, Speech, and Hearing Services in Schools 28, no. 2 (April 1997): 99–107. http://dx.doi.org/10.1044/0161-1461.2801.99.

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Changes in demographic and economic trends, as well as reforms in health care and education, have encouraged speech-language pathologists to expand the service delivery options they offer. Practitioners are searching for service delivery models that promote clients’ functional skills, are cost-effective, and reflect accountability and efficacy. There is increasing demand for models that incorporate team decision-making and participation. This article provides clinicians with a framework for decision-making and service delivery by encouraging speech-language pathologists and their colleagues to consider the unique combination of providers, activities, and contexts (PACs) necessary to meet the specific needs of each individual with a communication disorder.

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11

Yonnet, Paul. "Pacs." Le Débat 112, no. 5 (2000): 105. http://dx.doi.org/10.3917/deba.112.0105.

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12

Tenan, Paul M., Herbert H. Fillmore, Barbara Caress, William P. Kelly, Howard Nelson, Dennis Graziano, and Steven C. Johnson. "PACs." Journal of Ambulatory Care Management 11, no. 3 (August 1988): 36–53. http://dx.doi.org/10.1097/00004479-198808000-00005.

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13

Le Hen, A., and J. E. Lefevre. "PACS." Journal de Radiologie 85, no. 7-8 (July 2004): 1046–53. http://dx.doi.org/10.1016/s0221-0363(04)97718-9.

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14

Le Hen, A., and S. Baczynski. "PACS." IRBM News 32, no. 2-3 (June 2011): 56–59. http://dx.doi.org/10.1016/j.irbmnw.2011.03.011.

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15

Decouvelaere, Martine, Jean-Eric Lefèvre, Stéphane Pierrefitte, and Aurélie Supiot. "PACs." ITBM-RBM News 24, no. 1 (February 2003): 22–23. http://dx.doi.org/10.1016/s1297-9570(03)80008-0.

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Le Hen, Alain, and Jean-Eric Lefèvre. "PACS." ITBM-RBM News 25, no. 1 (February 2004): 27–29. http://dx.doi.org/10.1016/s1297-9570(04)80012-8.

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17

Lenhart, M., A. Haueis, H. Schneider, E. M. Jung, T. Herold, S. Feuerbach, V. Schöffl, and N. Zorger. "PACS." Der Orthopäde 39, no. 10 (April 11, 2010): 994–1002. http://dx.doi.org/10.1007/s00132-010-1616-2.

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18

Schultze, OC, J. Greyling, M. Hayes, and S. Andronikou. "Talking PACS: Part 1 - What is PACS?" South African Journal of Radiology 11, no. 3 (November 27, 2007): 50. http://dx.doi.org/10.4102/sajr.v11i3.31.

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19

Viel, Annette, and Anne Nivart. "Parcs sous tension." Culture & Musées 5, no. 1 (2005): 135–56. http://dx.doi.org/10.3406/pumus.2005.1217.

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20

Anisimov, A. V., A. V. Derevianchenko, P. P. Kuliabko, and O. M. Fedorus. "Programming System PARCS." Journal of Computer and Communications 05, no. 09 (2017): 129–39. http://dx.doi.org/10.4236/jcc.2017.59009.

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21

Jones, Peter. "Center Parcs UK." Tourism and Hospitality Research 4, no. 2 (December 2002): 174–82. http://dx.doi.org/10.1177/146735840200400207.

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22

Kobayashi, Yusuke, Kensuke Kumamoto, Hirokazu Okayama, Takuro Matsumoto, Hiroshi Nakano, Katsuharu Saito, Yoshiko Matsumoto, et al. "Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer." PLOS ONE 16, no. 2 (February 17, 2021): e0247169. http://dx.doi.org/10.1371/journal.pone.0247169.

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Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) encodes an enzyme that catalyzes de novo purine biosynthesis. Although PAICS has been implicated as a potential therapeutic target in several cancers, its clinical and prognostic significance in colorectal cancer (CRC) is not fully understood. To elucidate the roles of PAICS in CRC, we investigated PAICS expression in four cohorts consisting of a total of 1659 samples based on quantitative RT-PCR, microarray and RNA-seq analysis. Despite upregulated PAICS levels in tumor compared to those of normal mucosa, we found a decreasing trend of PAICS expression during tumor progression and metastasis. We conducted immunohistochemistry on 252 specimens, showing that PAICS protein was strongly expressed in the majority of CRCs, but not in adjacent mucosa. Notably, 29.0% of tumors lacked PAICS staining, and PAICS-negative expression in tumor had significant prognostic impact on poor cancer-specific survival in stage III CRC. Correspondingly, decreased levels of PAICS transcript were also correlated with poor relapse-free survival particularly in stage III patients, and this finding was robustly confirmed in three microarray datasets of a total of 802 stage II-III patients. Bioinformatics analysis of CRC tissues and cell lines consistently indicated a correlation between decreased PAICS expression and copy number loss of chromosome arm 4q. In conclusion, our results suggest that PAICS expression is downregulated during tumor progression due to genetic deletion of chromosome 4q in microsatellite stable but chromosomally unstable tumors. Furthermore, decreased expression of PAICS transcript or loss of PAICS protein may provide prognostic stratification for postoperative patients with stage III CRC.

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23

Cosson, Arnaud. "Parcs naturels régionaux et parcs nationaux : Convergences et défis communs." Pour N° 243, no. 2 (May 19, 2022): 185–91. http://dx.doi.org/10.3917/pour.243.0185.

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24

Gien, Jason, Gregory J. Seedorf, Vivek Balasubramaniam, Nancy Tseng, Neil Markham, and Steven H. Abman. "Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro." American Journal of Physiology-Lung Cellular and Molecular Physiology 295, no. 4 (October 2008): L680—L687. http://dx.doi.org/10.1152/ajplung.00516.2007.

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Persistent pulmonary hypertension of the newborn (PPHN) is characterized by endothelial dysfunction and decreased vascular growth. The role of Rho kinase activity in modulating endothelial function and regulating angiogenesis during normal lung development and in PPHN is unknown. We hypothesized that PPHN increases Rho kinase activity in fetal pulmonary artery endothelial cells (PAECs) and impairs angiogenesis in vitro. Proximal PAECs were harvested from fetal sheep with partial ligation of the ductus arteriosus in utero (PPHN) and age-matched controls. Rho kinase activity was measured by RhoA, Rho GTP, and phosphorylated MYPT-1 protein content. The effects of Rho kinase activity on angiogenesis, endothelial nitric oxide (NO) synthase (eNOS) protein expression, and NO production were determined in normal and PPHN PAECs. Angiogenesis was assessed by tube formation in vitro with/without Y-27632 (a Rho kinase inhibitor) and calpeptin (a Rho kinase activator) in the presence/absence of N-nitro-l-arginine (l-NA, an NOS inhibitor). RhoA, Rho GTP, and phosphorylated MYPT-1 protein were increased in PPHN PAECs. Tube formation was reduced 29% in PPHN PAECs ( P < 0.001) and increased with Y-27632 treatment in normal and PPHN PAECs, with PPHN PAECs achieving levels similar to those of normal PAECs. l-NA inhibited the Y-27632-induced increase in tube formation in normal, but not PPHN, PAECs. Calpeptin reduced tube formation in normal and PPHN PAECs. eNOS expression was reduced 42% in PPHN PAECs ( P < 0.01). Y-27632 increased eNOS protein and NO production in normal and PPHN PAECs. Calpeptin decreased eNOS protein only in normal PAECs but reduced NO production in normal and PPHN PAECs. We conclude that Rho kinase activity is increased in PPHN PAECs and impairs angiogenesis and downregulates eNOS protein and NO production in vitro.

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Lépinasse, Pierre. "Les PACs." Revue Française d'Etudes Américaines 32, no. 1 (1987): 297–308. http://dx.doi.org/10.3406/rfea.1987.1280.

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26

Lieblich, Irving. "PACS Errata." Physics Today 38, no. 6 (June 1985): 102. http://dx.doi.org/10.1063/1.2814620.

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27

Honeyman-Buck, Janice. "PACS adoption." Seminars in Roentgenology 38, no. 3 (July 2003): 256–69. http://dx.doi.org/10.1016/s0037-198x(03)00045-2.

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28

Škerlová, Jana, Judith Unterlass, Mona Göttmann, Petra Marttila, Evert Homan, Thomas Helleday, Ann-Sofie Jemth, and Pål Stenmark. "Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target." Journal of Biological Chemistry 295, no. 33 (June 22, 2020): 11656–68. http://dx.doi.org/10.1074/jbc.ra120.013695.

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The bifunctional human enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS) catalyzes two essential steps in the de novo purine biosynthesis pathway. PAICS is overexpressed in many cancers and could be a promising target for the development of cancer therapeutics. Here, using gene knockdowns and clonogenic survival and cell viability assays, we demonstrate that PAICS is required for growth and survival of prostate cancer cells. PAICS catalyzes the carboxylation of aminoimidazole ribonucleotide (AIR) and the subsequent conversion of carboxyaminoimidazole ribonucleotide (CAIR) and l-aspartate to N-succinylcarboxamide-5-aminoimidazole ribonucleotide (SAICAR). Of note, we present the first structures of human octameric PAICS in complexes with native ligands. In particular, we report the structure of PAICS with CAIR bound in the active sites of both domains and SAICAR bound in one of the SAICAR synthetase domains. Moreover, we report the PAICS structure with SAICAR and an ATP analog occupying the SAICAR synthetase active site. These structures provide insight into substrate and product binding and the architecture of the active sites, disclosing important structural information for rational design of PAICS inhibitors as potential anticancer drugs.

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29

Mallin, Mikaela M., Nicholas Kim, Mohammad Ikbal Choudhury, SeJong Lee, Steven S. An, Sean X. Sun, Konstantinos Konstantopoulos, Sarah R. Amend, and Kenneth J. Pienta. "Abstract A017: Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells." Cancer Research 83, no. 2_Supplement_2 (January 15, 2023): A017. http://dx.doi.org/10.1158/1538-7445.metastasis22-a017.

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Abstract Metastasis is responsible for 90% of cancer deaths, yet on a cellular level, successful metastasis is rare. Barriers to metastasis exist at every step of the metastatic cascade (invasion, intravasation, survival in the circulation, extravasation, and colonization.) Modeling predicts that only one of every 1.5 billion circulating tumor cells results in clinically-detectable metastasis. Identification of the rare subset of metastasis-competent cells is the most crucial goal of cancer research. Polyanuploid Cancer Cells (PACCs) are physically enlarged, treatment-resistant cells with increased genomic content that form in response to stress. After stress-induction, PACCs exist in a non-proliferative state for many weeks before undergoing eventual depolyploidization to produce progeny of “typical” cancer cell size, morphology, and nuclear content. PACCs can be identified in both primary and metastatic patient tumor tissues. As such, we propose Polyaneuploid Cancer Cells (PACCs) are metastasis-competent cells. Single-cell tracking reveals that PACCs are more motile than nonPACCs. Additionally, we observe that PACCs exhibit increased directional migration in 2D chemotactic environments. Optical-tracking of spontaneous bead motion reveals that PACCs demonstrate increased cytoskeletal rearrangement, an observation that aligns with increased environment-sensing and directional motility. In total, this predicts successful invasion. Analyses of cellular deformability using Magnetic Twisting Cytometry and Atomic Force Microscopy jointly reveal that cells in the PACC state display hyper-elastic properties. Among these include increased peripheral deformability and maintained peri-nuclear cortical integrity, both of which predict successful intravasation and extravasation. Functional deformability of PACCs navigating through narrow channels in a chemotactic environment was confirmed using a custom microfluids device. RTqPCR, NanoString mRNA quantification, Western blot, and immunofluorescent imaging reveal that PACCs highly overexpress Vimentin, a cytoskeletal component known to confer hyper-elasticity. Notably, there is no correlation between Vimentin content and motility dynamics in PACCs, indicating that the role of Vimentin in PACCs may primarily drive increased hyper-elasticity rather than increased motility. Anoikis-resistance assays and detection of PACCs in the blood of a patient with metastatic prostate cancer using a selection-free circulating tumor cell detection platform reveal that PACCs are capable of surviving in the circulation. Our work to date reports that PACCs demonstrate increased motility, environment-sensing, hyper-elasticity, and anoikis-resistance. Taken together with the knowledge that PACCs exist in a treatment-resistant state and are capable of eventual depolyploidization (as a potential route to successful colony formation), this data suggests PACCs are a candidate rare metastasis-competent cell type worthy of further analysis. Citation Format: Mikaela M. Mallin, Nicholas Kim, Mohammad Ikbal Choudhury, SeJong Lee, Steven S. An, Sean X. Sun, Konstantinos Konstantopoulos, Sarah R. Amend, Kenneth J. Pienta. Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr A017.

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30

Agarwal, Sumit, Balabhadrapatruni V. S. K. Chakravarthi, Michael Behring, Hyung-Gyoon Kim, Darshan S. Chandrashekar, Nirzari Gupta, Prachi Bajpai, et al. "PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer." Cancers 12, no. 4 (March 25, 2020): 772. http://dx.doi.org/10.3390/cancers12040772.

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The identification of colorectal cancer (CRC) molecular targets is needed for the development of drugs that improve patient survival. We investigated the functional role of phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), a de novo purine biosynthetic enzyme involved in DNA synthesis, in CRC progression and metastasis by using cell and animal models. Its clinical utility was assessed in human CRC samples. The expression of PAICS was regulated by miR-128 and transcriptionally activated by Myc in CRC cells. Increased expression of PAICS was involved in proliferation, migration, growth, and invasion of CRC cells irrespective of the p53 and microsatellite status. In mice, the depletion of PAICS in CRC cells led to reduced tumor growth and metastatic cell dissemination to the liver, lungs, and bone. Positron emission tomography imaging showed significantly reduced metastatic lesions in stable PAICS knockdown CRC cells. In cells with PAICS knockdown, there was upregulation of the epithelial mesenchymal transition marker, E-cadherin, and bromodomain inhibitor, JQ1, can target its increased expression by blocking Myc. PAICS was overexpressed in 70% of CRCs, and was associated with poor 5-year survival independent of the pathologic stage, patient’s race, gender, and age. Overall, the findings point to the usefulness of PAICS targeting in the treatment of aggressive colorectal cancer.

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Deshaies, Marie-Ève, and René Charest. "La conservation des parcs nationaux au-delà de leurs frontières." Le Naturaliste canadien 142, no. 1 (November 22, 2017): 50–63. http://dx.doi.org/10.7202/1042013ar.

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Le réseau des parcs nationaux du Québec vise à assurer la conservation et la protection permanente de territoires représentatifs des régions naturelles du Québec ou de sites naturels exceptionnels. Cependant, dans certains parcs, principalement ceux au sud du 50e parallèle, il peut s’avérer ardu de répondre aux besoins des espèces à grand domaine vital en raison des superficies variables des parcs. De plus, l’utilisation ou la dégradation du territoire en périphérie de ces parcs peut contribuer à une perte de leur valeur écologique. Afin de favoriser la mise en oeuvre de la mission de conservation des parcs nationaux, la Société des établissements de plein air du Québec (Sépaq) a entrepris de mobiliser les acteurs dans les territoires périphériques des parcs. Elle s’est fixé pour objectifs de caractériser les zones périphériques, de tenir des journées de réflexion rassemblant les acteurs locaux et régionaux et de mobiliser ces derniers afin qu’ils réalisent des actions concrètes pour mieux conserver ces territoires. Le maintien des richesses écologiques des parcs repose, en partie, sur l’engagement des acteurs à participer aux efforts de conservation en périphérie des parcs afin de réduire les effets des activités humaines sur les territoires protégés et assurer le maintien des services écologiques essentiels.

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Senín-Calderón, Cristina, José Santos-Morocho, and Juan F. Rodríguez-Testal. "Validation of a Spanish Version of the Physical Appearance Comparison Scales." International Journal of Environmental Research and Public Health 17, no. 20 (October 11, 2020): 7399. http://dx.doi.org/10.3390/ijerph17207399.

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Physical appearance comparison has been widely studied because of its strong relationship with body dissatisfaction and disordered eating. The main objective of this study was to validate the physical appearance comparison scales (PACS-Revised and PACS-3) in a sample of Spanish men and women and examine their psychometric properties. The sample consisted of 1151 participants (age M = 22.31, SD = 3.40). A unidimensional structure was corroborated in the PACS-R, and three factors in the PACS-3 (proximal, distal, and muscularity comparisons). The PACS-R and PACS-3 showed full scalar invariance across sex. The internal consistency for the PACS-R and subscales of PACS-3 were satisfactory. Positive statistically significant relationships were found with measures of disordered eating (EAT-26) and dysmorphic concern (DCQ). Hierarchical multiple regression analyses demonstrated that the PACS-3 discretely improved the prediction of disordered eating over PACS-R, but did not show improvement in the prediction of dysmorphic concern beyond the PACS-R. These findings suggest that the PACS-R and PACS-3 may be useful tools for evaluating the tendency of men and women to compare their physical appearance.

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Lee, Sang-Do, Dong-Soon Lee, Yong-Gam Chun, Tae-Sun Shim, Chae-Man Lim, Younsuck Koh, Woo-Sung Kim, Dong-Soon Kim, and Won-Dong Kim. "Cigarette smoke extract induces endothelin-1 via protein kinase C in pulmonary artery endothelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 281, no. 2 (August 1, 2001): L403—L411. http://dx.doi.org/10.1152/ajplung.2001.281.2.l403.

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We examined the mechanism of endothelin (ET)-1 regulation by cigarette smoke extract (CSE) and the effect of platelets on CSE-induced stimulation of ET-1 gene expression in human and bovine pulmonary artery endothelial cells (PAECs). Our data show that CSE (1%) induces ET-1 gene expression (after 1 h) and ET-1 peptide synthesis (after 4 h) in bovine PAECs. The induction of preproET-1 mRNA level was due to de novo transcription, and new protein synthesis was not required for this induction. The protein kinase C inhibitors staurosporine (10−8mol/l) and calphostin C (10−7mol/l) abolished the induction of ET-1 gene expression by CSE in bovine and human PAECs. Although a lower concentration of platelets (106cells/ml in bovine PAECs; 107cells/ml in human PAECs) did not significantly alter ET-1 gene expression in PAECs, incubation of platelets with CSE (1%) and PAECs produced a significant increase in preproET-1 mRNA and ET-1 peptide compared with the values in the presence of CSE (1%) alone. CSE (1%) induced platelet aggregation and increased the expression of platelet membrane glycoproteins ex vivo. Thus our data suggest that CSE stimulates ET-1 gene expression via PKC in PAECs. CSE and platelets showed a synergistic effect on ET-1 gene expression, possibly through the activation of platelets by CSE.

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34

Tielemans, Birger, Leanda Stoian, Allard Wagenaar, Mathias Leys, Catharina Belge, Marion Delcroix, and Rozenn Quarck. "Incremental Experience in In Vitro Primary Culture of Human Pulmonary Arterial Endothelial Cells Harvested from Swan-Ganz Pulmonary Arterial Catheters." Cells 10, no. 11 (November 19, 2021): 3229. http://dx.doi.org/10.3390/cells10113229.

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Pulmonary arterial hypertension (PAH) is a devastating condition affecting the pulmonary microvascular wall and endothelium, resulting in their partial or total obstruction. Despite a combination of expensive vasodilatory therapies, mortality remains high. Personalized therapeutic approaches, based on access to patient material to unravel patient specificities, could move the field forward. An innovative technique involving harvesting pulmonary arterial endothelial cells (PAECs) at the time of diagnosis was recently described. The aim of the present study was to fine-tune the initial technique and to phenotype the evolution of PAECs in vitro subcultures. PAECs were harvested from Swan-Ganz pulmonary arterial catheters during routine diagnostic or follow up right heart catheterization. Collected PAECs were phenotyped by flow cytometry and immunofluorescence focusing on endothelial-specific markers. We highlight the ability to harvest patients’ PAECs and to maintain them for up to 7–12 subcultures. By tracking the endothelial phenotype, we observed that PAECs could maintain an endothelial phenotype for several weeks in culture. The present study highlights the unique opportunity to obtain homogeneous subcultures of primary PAECs from patients at diagnosis and follow-up. In addition, it opens promising perspectives regarding tailored precision medicine for patients suffering from rare pulmonary vascular diseases.

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35

Wang, Jong Rong, Hao Tzu Lin, Hsiung Chih Chen, and Chun Kuan Shih. "The MSIV Closure Direct Scram Transient Analysis of Lungmen ABWR Using TRACE/PARCS." Advanced Materials Research 608-609 (December 2012): 844–47. http://dx.doi.org/10.4028/www.scientific.net/amr.608-609.844.

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This study consists of two steps. The first step is the development of a TRACE (TRAC/RELAP Advanced Computational Engine)/PARCS(Purdue Advanced Reactor Core Simulator) model of Lungmen nuclear power plant (NPP) which includes the vessel, reactor internal pumps (RIPs), main steam lines, and important control systems (such as the feedwater control system, steam bypass & pressure control system, and recirculation flow control system), etc.. Key parameters were identified to refine the TRACE/PARCS model further in the frame of a steady state analysis. The second step is the performance of Lungmen NPP TRACE/PARCS model transient analyses. The MSIV closure direct scram (MSIVCD, MSIV = Main Steamline Isolation Valve) transient data of Final Safety Analysis Report (FSAR) is used to verify the Lungmen NPP TRACE/PARCS model. The trends of TRACE/PARCS analysis results are consistent with the FSAR data. It indicates that there is a respectable accuracy in the Lungmen NPP TRACE/PARCS model.

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Roy, Jean-Bernard. "Les parcs archeologiques au risque du parcs de divertissement. Los parques arqueológicos corren el riesgo de convertirse en parques de diversiones." Entornos 26, no. 2 (September 30, 2013): 95–109. http://dx.doi.org/10.25054/01247905.477.

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L’histoire des parcs archéologiques, en France, débute en 1972, avec l’ouverture du Thot, en Dordogne. La première génération de parcs, avec le célèbre Archéodrome de Beaune, en Bourgogne, apparaît en même temps que les parcs naturels régionaux (PNR) et les premiers musées de plein air et écomusées, dans le cadre d’une politique d’aménagement du territoire, pour les sites naturels, archéologiques et historiques. Les parcs utilisent toutes les ressources de la reconstitution des vestiges préhistoriques et historiques, au moyen de l’archéologie expérimentale. Certains d’entre eux intègrent les temps géologiques avec les «dinosaures». Ils sont toujours situés dans des sites naturels. Cette reconstitution du passé est en rupture avec les musées de site traditionnels, avec les risques d’une culture de masse qui privilégie le divertissement au détriment du culturel «disneylandisation»). Le concept s’avère cependant pérationnel pour les nouveaux musées archéologiques qui l’utilisent aujourd’hui: les parcs-musées archéologiques ne sont plus seulement des parcs de divertissement.

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37

Mazzero, Hugo. "Les impacts des parcs de la paix sur les frontières en Afrique australe : un rêve d’ouverture qui peine à se réaliser." Frontières et espaces transfrontaliers, une approche environnementale, no. 3 (December 13, 2021): 81–98. http://dx.doi.org/10.57086/rrs.189.

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Cet article s’intéresse aux impacts de la conservation transfrontalière sur les frontières internationales, à partir du cas des parcs de la paix en Afrique australe. Nous analysons dans quelle mesure les frontières sont transformées et/ou mobilisées au nom d’enjeux environnementaux, tout en interrogeant la capacité de ces parcs à créer de nouveaux espaces transfrontaliers. Après être revenu sur la dimension temporelle des parcs de la paix, l’article présente leurs principales caractéristiques ainsi que le contexte de leur mise en place puis analyse comment les parcs de la paix transforment les frontières par un processus d’ouverture et de délinéarisation. Il montre enfin en quoi les enjeux actuels auxquels sont confrontés les parcs de la paix réinterrogent la place et les usages des frontières.

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38

Pelet, Anna, Vaclava Skopova, Ulrike Steuerwald, Veronika Baresova, Mohammed Zarhrate, Jean-Marc Plaza, Ales Hnizda, et al. "PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome." Human Molecular Genetics 28, no. 22 (October 10, 2019): 3805–14. http://dx.doi.org/10.1093/hmg/ddz237.

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Abstract We report for the first time an autosomal recessive inborn error of de novo purine synthesis (DNPS)—PAICS deficiency. We investigated two siblings from the Faroe Islands born with multiple malformations resulting in early neonatal death. Genetic analysis of affected individuals revealed a homozygous missense mutation in PAICS (c.158A>G; p.Lys53Arg) that affects the structure of the catalytic site of the bifunctional enzyme phosphoribosylaminoimidazole carboxylase (AIRC, EC 4.1.1.21)/phosphoribosylaminoimidazole succinocarboxamide synthetase (SAICARS, EC 6.3.2.6) (PAICS). The mutation reduced the catalytic activity of PAICS in heterozygous carrier and patient skin fibroblasts to approximately 50 and 10% of control levels, respectively. The catalytic activity of the corresponding recombinant enzyme protein carrying the mutation p.Lys53Arg expressed and purified from E. coli was reduced to approximately 25% of the wild-type enzyme. Similar to other two known DNPS defects—adenylosuccinate lyase deficiency and AICA-ribosiduria—the PAICS mutation prevented purinosome formation in the patient’s skin fibroblasts, and this phenotype was corrected by transfection with the wild-type but not the mutated PAICS. Although aminoimidazole ribotide (AIR) and aminoimidazole riboside (AIr), the enzyme substrates that are predicted to accumulate in PAICS deficiency, were not detected in patient’s fibroblasts, the cytotoxic effect of AIr on various cell lines was demonstrated. PAICS deficiency is a newly described disease that enhances our understanding of the DNPS pathway and should be considered in the diagnosis of families with recurrent spontaneous abortion or early neonatal death.

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39

Browne, Ronan F. J., and William C. Torreggiani. "Capturing PACS Images." American Journal of Roentgenology 180, no. 1 (January 2003): 285. http://dx.doi.org/10.2214/ajr.180.1.1800285.

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40

Standish, Katerina. "A PACS Problématique." Peace Review 33, no. 2 (April 3, 2021): 310–18. http://dx.doi.org/10.1080/10402659.2021.1998864.

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41

McGeary, Danielle. "PACS—An Overview." Biomedical Instrumentation & Technology 43, no. 2 (March 1, 2009): 127–30. http://dx.doi.org/10.2345/0899-8205-43.2.127.

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42

Poglitsch, A., and B. Altieri. "The PACS Instrument." EAS Publications Series 34 (December 20, 2008): 43–62. http://dx.doi.org/10.1051/eas:0934004.

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43

Milgrom, P., and J. M. Tanzer. "Perspectives on PACS." Journal of Dental Research 91, no. 2 (December 7, 2011): 122–24. http://dx.doi.org/10.1177/0022034511431458.

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44

Feder, Toni. "New PACS®." Physics Today 55, no. 11 (November 2002): 32. http://dx.doi.org/10.1063/1.4796569.

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45

Jalbert, S. "Integration d’un PACS." Journal de Radiologie 85, no. 9 (September 2004): 1154. http://dx.doi.org/10.1016/s0221-0363(04)76504-x.

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46

Claudon, M., and F. Lefèvre. "Utiliser un PACS." Journal de Radiologie 85, no. 9 (September 2004): 1435. http://dx.doi.org/10.1016/s0221-0363(04)77419-3.

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47

Le Goualher, G. "PACS lumiere visible." Journal de Radiologie 86, no. 10 (October 2005): 1175. http://dx.doi.org/10.1016/s0221-0363(05)74885-x.

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48

Stacul, Fulvio. "Ultrasonography and PACS." European Journal of Radiology 27 (May 1998): S196—S199. http://dx.doi.org/10.1016/s0720-048x(98)00062-x.

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Linthicum, David S. "PaaS Death Watch?" IEEE Cloud Computing 4, no. 1 (January 2017): 6–9. http://dx.doi.org/10.1109/mcc.2017.1.

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Le Hen, A., and S. Pierrefitte. "Rsna 2004 Pacs." Journal de Radiologie 86, no. 7-8 (August 2005): 931–37. http://dx.doi.org/10.1016/s0221-0363(05)81471-4.

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