Academic literature on the topic 'P38a'
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Journal articles on the topic "P38a"
Hale, Karin K., David Trollinger, Marynette Rihanek, and Carl L. Manthey. "Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase α, β, γ, and δ in Inflammatory Cell Lineages." Journal of Immunology 162, no. 7 (April 1, 1999): 4246–52. http://dx.doi.org/10.4049/jimmunol.162.7.4246.
Full textRisco, Ana, and Ana Cuenda. "New Insights into the p38γ and p38δ MAPK Pathways." Journal of Signal Transduction 2012 (November 30, 2012): 1–8. http://dx.doi.org/10.1155/2012/520289.
Full textAdachi-Yamada, Takashi, Makoto Nakamura, Kenji Irie, Yoshinori Tomoyasu, Yorikata Sano, Eiji Mori, Satoshi Goto, Naoto Ueno, Yasuyoshi Nishida, and Kunihiro Matsumoto. "p38 Mitogen-Activated Protein Kinase Can Be Involved in Transforming Growth Factor β Superfamily Signal Transduction in Drosophila Wing Morphogenesis." Molecular and Cellular Biology 19, no. 3 (March 1, 1999): 2322–29. http://dx.doi.org/10.1128/mcb.19.3.2322.
Full textXing, Feiyue, Yong Jiang, Jing Liu, Kesen Zhao, Yongyan Mo, Zhifeng Liu, and Yaoying Zeng. "Downregulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation." Biochemistry and Cell Biology 84, no. 5 (October 2006): 780–89. http://dx.doi.org/10.1139/o06-092.
Full textRoche, Olga, Diego M. Fernández-Aroca, Elena Arconada-Luque, Natalia García-Flores, Liliana F. Mellor, María José Ruiz-Hidalgo, and Ricardo Sánchez-Prieto. "p38β and Cancer: The Beginning of the Road." International Journal of Molecular Sciences 21, no. 20 (October 12, 2020): 7524. http://dx.doi.org/10.3390/ijms21207524.
Full textGonzalez, Maria E., Shilpa R. Tekula, Talha Anwar, Shoshana A. Leflein, and Celina G. Kleer. "Abstract PD3-03: EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression." Cancer Research 82, no. 4_Supplement (February 15, 2022): PD3–03—PD3–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd3-03.
Full textGutierrez-Sanmartin, Dolores, Eduardo Varela-Ledo, Antonio Aguilera, Susana Romero-Yuste, Patricia Romero-Jung, Antonio Gomez-Tato, and Benito J. Regueiro. "Implication of p38 mitogen-activated protein kinase isoforms (α, β, γ and δ) in CD4+ T-cell infection with human immunodeficiency virus type I." Journal of General Virology 89, no. 7 (July 1, 2008): 1661–71. http://dx.doi.org/10.1099/vir.0.82971-0.
Full textKUMA, Yvonne, David G. CAMPBELL, and Ana CUENDA. "Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta." Biochemical Journal 379, no. 1 (April 1, 2004): 133–39. http://dx.doi.org/10.1042/bj20031559.
Full textThouverey, Cyril, and Joseph Caverzasio. "Ablation of p38α MAPK Signaling in Osteoblast Lineage Cells Protects Mice From Bone Loss Induced by Estrogen Deficiency." Endocrinology 156, no. 12 (October 6, 2015): 4377–87. http://dx.doi.org/10.1210/en.2015-1669.
Full textLovett, Fiona A., Ruth A. Cosgrove, Ivelisse Gonzalez, and Jennifer M. Pell. "Essential Role for p38α MAPK But Not p38γ MAPK in Igf2 Expression and Myoblast Differentiation." Endocrinology 151, no. 9 (July 7, 2010): 4368–80. http://dx.doi.org/10.1210/en.2010-0209.
Full textDissertations / Theses on the topic "P38a"
Gutierrez, Prat Núria. "Molecular basis of p38a MAPK signaling." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663438.
Full textRenaud, Emilie. "Inhibition isoforme spécifique des fonctions de la MAPK p38α par des fragments d’anticorps." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT088.
Full textMAPK p38α is a key protein in inflammation, but is also involved in many cancer-related processes. All the currently described chemical inhibitors of p38α inhibit its kinase activity by an ATP-competitive mechanism. Because of the high conservation of the ATP-binding pocket, the majority of these inhibitors are not specific to p38α and off-target effects have been reported. To identify alternative approaches to inhibit p38α MAPK, my thesis project focused on the use of scFv antibody fragments as a new highly specific pharmacological tool.Antibody fragments bind to an antigen with high affinity and specificity like conventional immunoglobulins. Their intracellular expression also allows to target cytoplasmic proteins and study the target functions in physiological and pathological processes. Using a naïve library of antibody fragments, we have selected by phage display five scFv specific of MAPK p38α isoform. While all these scFv inhibit the activation of p38α by MMK6, one of them also completely inhibits its kinase activity in vitro. This scFv has a binding site and a mechanism of inhibition distinct from the pharmacological inhibitors currently described: although it does not target the ATP-binding pocket and does not prevent ATP binding, it behaves like a competitive inhibitor of ATP hydrolysis. These results suggest an allosteric effect of this scFv on p38α activity and allow to characterize it as an unconventional competitive inhibitor. The determination of its epitope as well as the confirmation of its inhibitory activity once expressed in the cell cytosol will allow us to propose an alternative approach to target p38α function using antibody fragments.These data open up new perspectives for the design of more specific p38α chemical inhibitors than those currently available
Visseq, Alexia. "Conception et synthèse d’inhibiteurs sélectifs de protéines kinases pour le traitement de l’allodynie mécanique." Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAC048.
Full textChronic pain is a global public health priority which affects more than 20% of Europeans. Mechanical allodynia, a pain in response to normally innocuous stimuli, is one of the most prevalent pain symptoms. Despite intensive research toward the study of pain mechanisms, currently available treatments of pain are not always effective, and can produce side-effects. In this context, the aim of the project is to design, synthesize and evaluate selective inhibitors of protein kinases for the treatment of mechanical allodynia. During this PhD work, new selective inhibitors of the protein kinase p38α has been discovered. This protein kinase is known for its implication in chronic pain and mechanical allodynia. A structure-activity relationship study was performed to identify the important structural features allowing a gain of activity of molecules in vitro and in vivo using an animal model. The best compounds showed submicromolar IC50 values toward p38α and a strong inhibition of mechanical allodynia in vivo
Vitos, Faleato Jessica. "Role of p38α in lung tumor progression." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/462107.
Full textLos tumores evolucionan al adquirir anormalidades genéticas de manera secuencial, como la activación de K-Ras y la pérdida de funcionalidad de Tp53, que permiten a las células transformadas sobrevivir, proliferar, e invadir, así como acondicionar su microambiente. Simultáneamente, las células transformadas también han de lidiar con situaciones de estrés, incluyendo un metabolismo acelerado, un genoma altamente inestable, o el sistema de vigilancia de las células inmunes. Por lo tanto, las células cancerosas han de apoyarse en vías de señalización no-oncogénicas que les permiten tolerar las deficiencias en los sistemas de control de homeostasis, adaptarse a los nuevos requerimientos funcionales, y monitorizar los cambios en el microambiente para responder de manera apropiada. La vía de las p38 MAPK está íntimamente relacionada con la respuesta al estrés y es utilizada por las células para transducir señales extracelulares y orquestrar las respuestas correspondientes. p38α es el miembro de la familia de p38 MAPK más ampliamente expresado, y se le han atribuido clásicamente funciones supresoras tumorales gracias a su habilidad para detener el ciclo celular, inducir diferenciación, y desencadenar procesos apoptóticos. No obstante, hay evidencia de que el nivel de actividad de p38 MAPK podría estar incrementado en varios tipos de tumor humanos y, en algunos casos, se ha correlacionado con una baja supervivencia, lo que sugiere un papel pro-tumoral. En este estudio, hemos observado una correlación negativa entre los niveles de expresión de p38α y la supervivencia en pacientes de adenocarcinoma pulmonar. Hemos usado un modelo murino de cáncer de pulmón inducido por la expresión del oncogén K-Ras para demostrar que, efectivamente, p38α juega un papel dual durante el desarrollo de la carcinogénesis de pulmón. Por una parte, p38α evita la transformación maligna de las células pulmonares epiteliales sanas mediante la inducción de diferenciación celular. Sin embargo, en las células epiteliales pulmonares transformadas, p38α estimula la proliferación y la secreción de citocinas inflamatorias que preparan un nicho favorable para la progresión tumoral. p38α también juega un rol pro-tumorigénico al promover la vascularización del tumor y la immunotolerancia por parte de las células mieloides infiltradas. En conjunto, nuestros datos sugieren que la inhibición de esta vía de señalización podría ser útil en términos terapéuticos para los casos de adenocarcinoma de pulmón.
Thapa, Dibesh. "Targeting the interaction between p38α and TAB1." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/targeting-the-interaction-between-p38-and-tab1(9b1a1609-805a-4698-a673-2a686dabf905).html.
Full textMäkelä, Kimmo K. "Characterization and performance of electrorheological fluids based on pine oils /." Espoo, Finland : University of Oulu, 1999. http://www.vtt.fi/inf/pdf/publications/1999/P385.pdf.
Full textHeikkilä, Anna-Mari. "Inherent safety in process plant design : an index-based approach /." Espoo [Finland] : Technical Research Centre of Finland, 1999. http://www.vtt.fi/inf/pdf/publications/1999/P384.pdf.
Full textUosukainen, Seppo. "JMC method applied to active control of sound : theoretical extensions and new source configurations /." Espoo [Finland] : Technical Research Centre of Finland, 1999. http://www.vtt.fi/inf/pdf/publications/1999/P386.pdf.
Full textPatil, Ashok R. "High power shunt regulation of spacecraft solar arrays." Diss., Virginia Tech, 1995. http://hdl.handle.net/10919/40216.
Full textPatterson, Douglas T. "Tribopolymerization as an approach to two-stroke engine lubrication." Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-01312009-063142/.
Full textBooks on the topic "P38a"
Ross, Herbert E. Adventures of a P38 ace. Stockton, CA: Graphics West Printing, 2006.
Find full text1946-, Cerocchi Pio, ed. La P38 e la mela: Una presenza cristiana a Roma negli anni di piombo. Castel Bolognese (RA) [i.e. Ravenna, Italy]: Itaca, 2009.
Find full textPurnama, Eddy. Pembentukan dan pembinaan P3A beririgasi di Kabupaten Daerah Tingkat II Aceh Utara: Laporan penelitian. [Banda Aceh]: Fakultas Hukum, Universitas Syiah Kuala, 1998.
Find full textMuliawati, Endang Setia. Studi pengembangan perkumpulan petani pemakai air (P3A) dalam pengelolaan sumberdaya air dan lahan: Laporan penelitian. Surakarta: Fakultas Pertanian, Universitas Sebelas Maret, 1997.
Find full textHermajanda, Dadan. Keragaan organisasi Perkumpulan Petani Pemakai Air (P3A) sepanjang Sungai Cisangkuy, Kabupaten Bandung, Jawa Barat: Laporan penelitian. Bandung: Pusat Dinamika Pembangunan, Universitas Padjadjaran, 1999.
Find full textFurtak, Teresa. Role of p38 MAP kinase in apoptosis in L-glutamine deprived SP2/0-Ag14 mouse hybridoma cells. Sudbury, Ont: Laurentian University, 2004.
Find full textAndriani, Haslinda B. Motivasi masyarakat dalam pembentukan perkumpulan petani pemakai air (P3A) di Kecamatan Parigi, Kabupaten Parigi Moutong: Laporan penelitian dosen muda. [Palu]: Fakultas Ilmu Sosial dan Ilmu Politik, Universitas Tadulako, 2005.
Find full textNaldi, Hendra. Pengaruh pelatihan perkumpulan petani pemakai air (P3A) terhadap partisipasi wanita tani dalam kegiatan pengelolaan irigasi di daerah irigasi Batang Anai, Padang Pariaman: Laporan penelitian. [Padang]: Institut Keguruan dan Ilmu Pendidikan Padang, 1999.
Find full textWalther P38 Pistol. Naval & Military Press, 2003.
Find full textP38 Signaling Pathway. MDPI, 2021. http://dx.doi.org/10.3390/books978-3-0365-0859-7.
Full textBook chapters on the topic "P38a"
Cha, Hyuk-Jin, and Albert J. Fornace. "P38." In Cancer Therapeutic Targets, 805–15. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_85.
Full textCha, Hyuk-Jin, and Albert J. Fornace. "P38." In Cancer Therapeutic Targets, 1–11. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6613-0_85-1.
Full textDonato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, et al. "P-38α (Phospho p38α)." In Encyclopedia of Signaling Molecules, 1331. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100980.
Full textQi, Xiao-Mei, Fang Wang, and Guan Chen. "p38 Gamma MAPK." In Encyclopedia of Signaling Molecules, 3718–27. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101521.
Full textPapaconstantinou, John, Ching-Chyuan Hsieh, and James H. DeFord. "p38 MAPK Family." In Encyclopedia of Signaling Molecules, 3728–39. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_221.
Full textQi, Xiao-Mei, Fang Wang, and Guan Chen. "p38 Gamma MAPK." In Encyclopedia of Signaling Molecules, 1–11. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101521-1.
Full textPapaconstantinou, John, Ching-Chyuan Hsieh, and James H. DeFord. "p38 MAPK Family." In Encyclopedia of Signaling Molecules, 1–12. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-6438-9_221-1.
Full textWaud, William R. "Murine L1210 and P388 Leukemias." In Tumor Models in Cancer Research, 23–41. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-968-0_2.
Full textWaud, William R. "Murine L1210 and P388 Leukemias." In Anticancer Drug Development Guide, 79–97. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-739-0_5.
Full textWaud, William R. "Murine L1210 and P388 Leukemias." In Anticancer Drug Development Guide, 59–74. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-4615-8152-9_4.
Full textConference papers on the topic "P38a"
Tsai, Ying-Kuan, and Richard J. Malak. "A Constraint-Handling Technique for Parametric Optimization and Control Co-Design." In ASME 2022 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/detc2022-89957.
Full textReynolds, Claire, Molly Cremin, and Susanna Felsenstein. "P382 Thinking outside the POX." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.728.
Full textFigueirinha, Joana, Sara Rolim, Ana Sofia Gomes, Filipa Pinto, and Paulo Teixeira. "P384 More than meets the eye." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.730.
Full textBarbee, Kenneth A., Gulyeter Serbest, and Joel Horwitz. "Membrane Integrity as a Therapeutic Target in Neural Cell Injury." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61566.
Full textZeh, G., M. Köhne, T. Sauerwald, H. Haug, and B. Lok. "P38 - Entwicklung instrumenteller Geruchsmessung." In 16. Dresdner Sensor-Symposium 2022. AMA Service GmbH, Von-Münchhausen-Str. 49, 31515 Wunstorf, Germany, 2022. http://dx.doi.org/10.5162/16dss2022/p38.
Full textGaspar, P., J. Rowley, A. Pati Pascom, F. Martinez, E. Korenromp, G. Mendes Pereira, and A. Miranda. "P381 Estimating adult gonorrhea prevalence in Brazil." In Abstracts for the STI & HIV World Congress, July 14–17 2021. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/sextrans-2021-sti.416.
Full textWolfe, Valerie M., Seonghun Park, Marjana Tomic, Peter A. Torzilli, and C. T. Christopher Chen. "Load Down-Regulates TNF-Alpha Induced Cartilage Degradation in Part Through NF-KB and P38 Pathways." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176541.
Full textConlon, Kevin, Molly Cremin, Daragh Finn, Clodagh Ryan, Michael Moore, and Niamh McSweeney. "P383 Stroke in children; consider parvovirus B19 infection." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.729.
Full textCama, Valeria, Luisa Pieragostini, Giovanna Fontanelli, Maria Rosa Velletri, and Calafiore Mariarosa. "P387 Clostridium difficile severe infection in a newborn." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.733.
Full text"REVERSE LOGISTICS OF TEŠANJ – WASTE MANAGEMENT SYSTEM." In Transport for Today's Society. Faculty of Technical Sciences Bitola, 2019. http://dx.doi.org/10.20544/tts2018.p38.
Full textReports on the topic "P38a"
Bakin, Andrei V. P38 Mitogen-Activated Protein Kinase in Metastasis Associated With Transforming Growth Factor Beta. Fort Belvoir, VA: Defense Technical Information Center, June 2005. http://dx.doi.org/10.21236/ada443019.
Full textBakin, Andrei. p38 Mitogen-Activated Protein Kinase in Metastasis Associated with Transforming Growth Factor Beta. Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada456265.
Full textBakin, Andrei V. P38 Mitogen-Activated Protein Kinase in Metastasis Associated with Transforming Growth Factor Beta. Fort Belvoir, VA: Defense Technical Information Center, June 2004. http://dx.doi.org/10.21236/ada427109.
Full textBakin, Andrei V. P38 Mitogen-Activated Protein Kinase in Metastasis Associated With Transforming Growth Factor Beta. Fort Belvoir, VA: Defense Technical Information Center, June 2003. http://dx.doi.org/10.21236/ada417915.
Full textVanhoy, Lyndsay. The SDF1-CXCR4 Axis Functions through p38-MAPK Signaling to Drive Breast Cancer Progression and Metastasis. Fort Belvoir, VA: Defense Technical Information Center, September 2008. http://dx.doi.org/10.21236/ada495339.
Full textVanhoy, Lyndsay. The SDF1-CXCR4 Axis Functions through p38-MAPK Signaling to Drive Breast Cancer Progression and Metastasis. Fort Belvoir, VA: Defense Technical Information Center, September 2008. http://dx.doi.org/10.21236/ada517434.
Full textLofgren, Kristopher. Investigation of the Role of Breast Tumor Kinase (Brk) in ERK5 and p38-Mediated Breast Cancer Cell. Fort Belvoir, VA: Defense Technical Information Center, October 2007. http://dx.doi.org/10.21236/ada484006.
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