Academic literature on the topic 'P-glycoprotein inhibitors'
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Journal articles on the topic "P-glycoprotein inhibitors"
Gherbovet, Olga, María Concepción García Alvarez, Jérôme Bignon, and Fanny Roussi. "Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors." Journal of Medicinal Chemistry 59, no. 23 (November 23, 2016): 10774–80. http://dx.doi.org/10.1021/acs.jmedchem.6b00525.
Full textChae, Song Wha, Jaeok Lee, Jung Hyun Park, Youngjoo Kwon, Younghwa Na, and Hwa Jeong Lee. "Intestinal P-glycoprotein inhibitors, benzoxanthone analogues." Journal of Pharmacy and Pharmacology 70, no. 2 (December 13, 2017): 234–41. http://dx.doi.org/10.1111/jphp.12832.
Full textal-Shawi, M. K., I. L. Urbatsch, and A. E. Senior. "Covalent inhibitors of P-glycoprotein ATPase activity." Journal of Biological Chemistry 269, no. 12 (March 1994): 8986–92. http://dx.doi.org/10.1016/s0021-9258(17)37065-5.
Full textKono, Yusuke, Iichiro Kawahara, Kohei Shinozaki, Ikuo Nomura, Honoka Marutani, Akira Yamamoto, and Takuya Fujita. "Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs." Pharmaceutics 13, no. 3 (March 15, 2021): 388. http://dx.doi.org/10.3390/pharmaceutics13030388.
Full textPleban, Karin, and Gerhard Ecker. "Inhibitors of P-Glycoprotein - Lead Identification and Optimisation." Mini-Reviews in Medicinal Chemistry 5, no. 2 (February 1, 2005): 153–63. http://dx.doi.org/10.2174/1389557053402729.
Full textYu, Jun, Peng Zhou, James Asenso, Xiao-Dan Yang, Chun Wang, and Wei Wei. "Advances in plant-based inhibitors of P-glycoprotein." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. 6 (March 2, 2016): 867–81. http://dx.doi.org/10.3109/14756366.2016.1149476.
Full textSrivalli, Kale Mohana Raghava, and P. K. Lakshmi. "Overview of P-glycoprotein inhibitors: a rational outlook." Brazilian Journal of Pharmaceutical Sciences 48, no. 3 (September 2012): 353–67. http://dx.doi.org/10.1590/s1984-82502012000300002.
Full textChang, Cheng, Praveen M. Bahadduri, James E. Polli, Peter W. Swaan, and Sean Ekins. "Rapid Identification of P-glycoprotein Substrates and Inhibitors." Drug Metabolism and Disposition 34, no. 12 (September 22, 2006): 1976–84. http://dx.doi.org/10.1124/dmd.106.012351.
Full textBogman, Katrijn, Anne-Kathrin Peyer, Michael Török, Ernst Küsters, and Jürgen Drewe. "HMG-CoA reductase inhibitors and P-glycoprotein modulation." British Journal of Pharmacology 132, no. 6 (March 2001): 1183–92. http://dx.doi.org/10.1038/sj.bjp.0703920.
Full textTarasova, Nadya I., Rishi Seth, Sergey G. Tarasov, Teresa Kosakowska-Cholody, Christine A. Hrycyna, Michael M. Gottesman, and Christopher J. Michejda. "Transmembrane Inhibitors of P-Glycoprotein, an ABC Transporter." Journal of Medicinal Chemistry 48, no. 11 (June 2005): 3768–75. http://dx.doi.org/10.1021/jm049065t.
Full textDissertations / Theses on the topic "P-glycoprotein inhibitors"
Jain, Ritesh Mitra Ashim K. "A novel approach to circumvent P-glycoporotein mediated cellular efflux and permeability enhancement of HIV protease inhibitor saquinavir." Diss., UMK access, 2007.
Find full text"A dissertation in pharmaceutical science and pharmacology." Advisor: Ashim K. Mitra. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed July 16, 2008. Includes bibliographical references (leaves 231-248). Online version of the print edition.
Row, Eleanor Catherine. "Design, synthesis and evaluation of coumarin and furanocoumarin compounds as inhibitors of CYP3A4 and P-glycoprotein." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401162.
Full textProfit, Louise. "The role of metabolism and P-glycoprotein mediated transport in the disposition of the HIV protease inhibitors." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366961.
Full textEdwards, Jeffrey Earl. "THE TRANSPORT AND MODULATION OF HIV PROTEASE INHIBITORS INTO THE RAT CENTRAL NERVOUS SYSTEM AND MILK." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/468.
Full textPatel, Jignesh Mitra Ashim K. "P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of HIV-protease inhibitor, ritonavir, and its interaction with pure herbal constituents." Diss., UMK access, 2004.
Find full text"A dissertation in pharmaceutical science and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed Feb. 27, 2006; title from "catalog record" of the print edition. Includes bibliographical references (leaves 175-199). Online version of the print edition.
Woodahl, Erica Lynn. "Genetic variation in the multidrug resistance gene (MDRI) : impact on drug delivery and disposition /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/7950.
Full textGashaw, Isabella. "Veränderungen in der Genexpression fremdstoffmetabolisierender Enzyme und Bedeutung genetischer Polymorphismen unter besonderer Berücksichtigung von HIV-Virustatika." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2003. http://dx.doi.org/10.18452/14958.
Full textThe therapy of HIV infection requires a combination of several antiretroviral substances accompanying risk factors for drug-drug interactions. Moreover, virus resistance can be promoted by enzyme induction caused by antiretroviral drugs. The aim of the study was to investigate the influences of antiretroviral substances on the expression of cytochrome P450 enzymes: 1A1, 1B1, 3A4 and p-glycoprotein (MDR1) using immortalized cell systems. The protease inhibitors indinavir, nelfinavir, ritonavir and saquinavir induced significantly the regulation of mRNA expression through the aryl hydrocarbon receptor (AhR) and the pregnane-x-receptor (PXR) in a concentration-dependent manner. The nucleoside reverse transcriptase inhibitors zalcitabine, zidovudine and lamivudine and the non-nucleoside reverse transcriptase inhibitor nevirapine showed inductive properties only for the AhR target genes CYP1A1 and CYP1B1.Amprenavir and efavirenz activated the PXR target genes. Potentially effects of the described induction are discussed. In a second part of the work, the molecular mechanisms of the individual varying activity of the CYP3A enzyme were investigated applying an in vivo study. CYP3A4 mRNA expression and rifampicin mediated induction in leucocytes were correlated with systemic enzyme activity under induction and known polymorphisms.
Jovelet, Cécile. "Interactions du vandetanib avec la P-glycoprotéine et passage d'une barrière physiologique : le placenta." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114825.
Full textOverexpression of ABC transporters, especially P-glycoprotein, is involved in multidrug resistance. In this study, we demonstrate that vandetanib, a tyrosine kinase inhibitor, is both substrate and inhibitor of P-glycoprotein and is able to reverse in vitro resistance to doxorubicin, linked to overexpression of P-glycoprotein.We also studied the placental transfer of vandetanib and we show that this drug crosses the placenta
Sonawane, Amit. "Evaluation of novel efflux transport inhibitor for the improvement of drug delivery through epithelial cell monolayer." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14424.
Full textOgunrombi, Modupe Olufunmilayo. "The effect of grapefruit juice, a P-glycoprotein inhibitor, on organic acid and conjugates urinary profile in healthy human subjects / M.O. Ogunrombi." Thesis, North-West University, 2004. http://hdl.handle.net/10394/411.
Full textThesis (M.Sc. (Pharm.))--North-West University, Potchefstroom Campus, 2004.
Books on the topic "P-glycoprotein inhibitors"
Huq, Rokaiya. Energy metabolism in human MCF-7 ADR and ADR-9 breast cancer cells treated with P-glycoprotein inhibitor PSC 833. Sudbury, Ont: Laurentian University, 2000.
Find full textKankesan, Janarthanan. Studies on the effect of PSC 833, a potent inhibitor of P-glycoprotein function on the development of cancer /cby Janarthanan Kankesan. 2006.
Find full textBook chapters on the topic "P-glycoprotein inhibitors"
Crowley, Emily, Christopher A. McDevitt, and Richard Callaghan. "Generating Inhibitors of P-Glycoprotein: Where to, Now?" In Methods in Molecular Biology, 405–32. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-416-6_18.
Full textWang, Qing, and Tina M. Sauerwald. "Screening for P-Glycoprotein (Pgp) Substrates and Inhibitors." In Methods in Pharmacology and Toxicology, 337–52. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-742-6_20.
Full textvan Triest, B., F. Telleman, H. M. Pinedo, C. L. van der Wilt, and G. J. Peters. "Cross-Resistance to Thymidylate Synthase Inhibitors in P-Glycoprotein and Non-P-Glycoprotein Cell Lines." In Purine and Pyrimidine Metabolism in Man VIII, 189–93. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_41.
Full textColey, Helen M. "Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors." In Methods in Molecular Biology, 341–58. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-416-6_15.
Full textOrlowski, S., J. Nugier, and Eric Ezan. "An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors." In Optimization in Drug Discovery, 89–102. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1385/1-59259-800-5:089.
Full textPalmeira, Andreia, Freddy Rodrigues, Emília Sousa, Madalena Pinto, M. Helena Vasconcelos, and Miguel X. Fernandes. "Pharmacophore-Based Screening as a Clue for the Discovery of New P-Glycoprotein Inhibitors." In Advances in Intelligent and Soft Computing, 175–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13214-8_23.
Full textNewman, Michael J., Ross Dixon, and Barry Toyonaga. "OC144-093, a Novel P glycoprotein Inhibitor for the Enhancement of Anti-Epileptic Therapy." In Novartis Foundation Symposia, 213–30. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470846356.ch16.
Full textGuttmann, Oliver P., Ronald Binder, Oliver Gämperli, and Andreas Baumbach. "Antithrombotics for Acute and Chronic Coronary Syndromes." In Manual of Cardiovascular Medicine, 117–24. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198850311.003.0014.
Full textKarthika, Chenmala, and Raman Sureshkumar. "P-Glycoprotein Efflux Transporters and Its Resistance Its Inhibitors and Therapeutic Aspects." In Creatinine - A Comprehensive Update [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.90430.
Full textPetrovic, Stanko, Slobodan Obradovic, Marijana Petrovic, and Nemanja Rancic. "Platelets in Ulcerative Colitis: From Pathophysiology to Therapy." In Ulcerative Colitis [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102041.
Full textConference papers on the topic "P-glycoprotein inhibitors"
Ravula, Ranadheer, Jeffrey Wang, and Ying Huang. "Abstract 1534: Bioassay-guided identification of novel P-glycoprotein inhibitors from traditional Chinese medicines." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1534.
Full textMohan, Rishabh, Aleem Gangjee, Ruoli Bai, and Ernest Hamel. "Abstract 4553: Substituted monocyclic pyrimidines as potent tubulin inhibitors that circumvent P-glycoprotein mediated resistance." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4553.
Full textAtkinson, Caroline, Carole Tactacan, Alvin Kamili, Federica Saletta, Christine Gana, Georgina Eden, Chelsea Mayoh, et al. "Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma." In Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.pedca19-a35.
Full textTripathi, Anushree, and Krishna Misra. "Stilbene analogues as inhibitors of breast cancer Stem cells through P-glycoprotein efflux; A 3D quantitative structure-activity relationship study (Inhibitory activity of stilbenes analogues on breast cancer stem cells)." In 2016 International Conference on Bioinformatics and Systems Biology (BSB). IEEE, 2016. http://dx.doi.org/10.1109/bsb.2016.7552134.
Full textMarongiu, F., M. R. Acca, G. Mulas, M. Conti, G. Sorano, and A. Balestrieri. "FIBRINOPEPTIDE B6 15-42 IN LIVER CIRRHOSIS: A SENSITIVE INDICATOR OF MILD FIBRINOLYSIS ACTIVATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643063.
Full textSudakova, E. A., A. V. Shchulkin, Y. V. Abalenikhina, and E. N. Yakusheva. "STUDY OF THE EFFECTS OF NITRIC OXIDE ON FUNCTIONING P - GLYCOPROTEIN." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.230-235.
Full textNedeljković, Nikola V., Vladimir D. Dobričić, Marina Ž. Mijajlović, Gordana P. Radić, Miloš V. Nikolić, Ana S. Stanković, and Zorica B. Vujić. "„IN SILICO“ PREDICTION OF PHARMACOKINETIC PROPERTIES AND DRUGLIKENESS OF NOVEL THIOUREA DERIVATIVES OF NAPROXEN." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.371n.
Full textPrasad Dash, Ranjeet, Bhanuchander Ellendula, and Manish Nivsarkar. "Influence of diabetes progression on intestinal absorption of P-glycoprotein substrate: Implication of epigallocatechin-3-gallate (P-glycoprotein inhibitor) for reducing intestinal drug efflux." In Annual International Conference on Pharmaceutical Sciences and Pharmacology. Global Science & Technology Forum (GSTF), 2013. http://dx.doi.org/10.5176/2345-783x_pharma13.08.
Full textAbalenikhina, Y. V., A. A. Seidkuliyeva, E. D. Rokunov, D. S. Nemtinov, A. V. Shchulkin, and E. N. Yakusheva. "PARTICIPATION OF NUCLEAR FACTOR OF ERYTHROID ORIGIN-2 IN REGU-LATION P-GLYCOPROTEIN IN MODELING ENDOGENOUS OXIDATIVE STRESS." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.251-257.
Full textHatachi, Y., H. Nagai, T. Mio, H. Yasuda, T. Sasaki, M. Asada, M. Mishima, and M. Yamaya. "Inhibitory Effects of Nitroglycerin on Intratumor P-Glycoprotein and Phospholyrated Caveolin-1 in Lewis Lung Carcinoma Bearing Murine Model." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5024.
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