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1

National Institutes of Health Consensus Development Conference on Ovarian Cancer (1994 National Institutes of Health). NIH Consensus Development Conference on Ovarian Cancer: Screening, treatment, and followup : NIH Consensus Development Conference, April 5-7, 1994 ... National Institutes of Health, Bethesda, Maryland. Bethesda, Md: National Institutes of Health, 1994.

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2

Doshi, Rajeev. Development of gene based immunotherapy for ovarian cancer. Birmingham: University of Birmingham, 1998.

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3

Health), NIH Consensus Development Conference on Ovarian Cancer (1994 National Institutes of. NIH Consensus Development Conference on Ovarian Cancer: Screening, treatment, and followup : [program and abstracts]. Bethesda, Md: National Institutes of Health, 1994.

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4

Makabe, Sayoko. Atlas of human female reproductive function: Ovarian development to early embryogenesis after in vitro fertilization. London: Taylor & Francis, 2006.

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5

Salinas, Josie. A pictorial guide on the ovarian development of the fertile and sterile Mexican fruitfly, Anastrepha ludens. Mission, TX: USDA-APHIS-PPQ, Mission Plant Protection Center, 1999.

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6

Galvin, James A. Ovarian follicular development following oestrus syncronization programmes at different stages of the oestrous cycle in lactating dairy cows. Dublin: University College Dublin, 1995.

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7

S, Tuan Rocky, and Lo Cecilia W, eds. Developmental biology protocols. Totowa, N.J: Humana Press, 2000.

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8

World Congress of Gynecological Endocrinology (4th 1995 Madonna di Campiglio, Italy). Recent developments in gynecology and obstetrics: Selected papers presented at the 4th World Congress of Gynecological Endocrinology organized by the International Society of Gynecological Endocrinology joint with the 2nd Congress of the European Society for Gynecologic and Obstetric Investigation, Madonna di Campiglio, Italy, February 1995. New York: Parthenon Pub. Group, 1996.

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9

Schoot. Exogenous Fsh and Development of Human Ovarian Follicles. Parthenon Pub Group, 1995.

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10

Lavoué, Vincent, Patrick Legembre, Jean Levêque, Fabrice Foucher, Sébastien Henno, and Florian Cabillic. Ovarian Cancer Immunity. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0003.

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Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the past three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an anti-tumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This chapter focuses on the immune response and immune suppression in EOC.
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11

Alharbi, Yousef, Manish S. Patankar, and Rebecca J. Whelan. Antibody-Based Therapy for Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0006.

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With their role in connecting disease-associated antigens to the cellular immune response, antibodies hold considerable promise as therapeutic agents. This chapter discusses three classes of therapeutic antibodies that have been developed for use in ovarian cancer therapy. The first includes antibodies selected against tumor-associated antigens such as MUC16/CA125, mesothelin, epithelial cell adhesion molecule, and folate receptor α‎. Antibodies in the second class target proteins such as CTLA-4 and PD1 that act as immune response checkpoint receptors. The third class of antibodies target secreted factors that promote tumor growth: targets in this class include vascular endothelial growth factor, cytokines, and chemokines. The development of each of these is described. The chapter also discusses the complications presented by soluble antigens, which serve to limit the applicability of antigens (such as MUC16/CA125) that are both cell-surface associated and circulating and the prospects for the combination of antibody-based immunotherapy and chemotherapy.
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12

Stashwick, Caitlin, Brian J. Czerniecki, and Janos L. Tanyi. Dendritic Cell Vaccine Therapy for Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0008.

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Dendritic cell vaccine therapy has emerged as an exciting new field in immunotherapy in ovarian cancer over the past two decades. This chapter reviews the biology of dendritic cells, including dendritic cell subsets, development, activation, and maturation as well as strategies for clinical use of dendritic cell vaccines. While there is encouraging data in preclinical work for dendritic cell vaccine, the outcomes of clinical trials have not shown robust responses. A summary of the clinical trials using dendritic cell vaccines in ovarian cancer is reviewed. Treatment-related toxicities and potential therapies to increase clinical efficacy are also discussed.
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13

Bendell, James John *. Transforming growth factor in the ovarian follicle: production, regulation, and role in growth and development. 1991.

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14

Makabe, Sayoko, and Jonathan van Blerkom. Atlas of Human Female Reproductive Function: Ovarian Development to Early Embryogenesis after In-Vitro Fertilization. Informa Healthcare, 2006.

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15

Messmer, Michelle N., Colleen S. Netherby, and Scott I. Abrams. Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0012.

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The immune system serves as an integral checkpoint to developing malignancies. However, when cancer ultimately becomes detectable, this implicates an inherent failure of effective immune control. One constant theme in cancer biology has been the ability of these “diseases,” in particular, ovarian cancer, to compromise immune-mediated mechanisms of neoplastic control. These empirical observations have subsequently laid the scientific foundation to investigate ways in which the immune system can be reengaged as a powerful therapeutic weapon, singly or in combination with other modalities. This field has been coined “cancer immunotherapy” and, importantly, strong progress has been made to date to justify its feasibility and potential merit. This chapter focuses on the fundamental immunologic principles that have guided the development of the cancer immunotherapy concept, as well as details both the successes and the limitations of cancer immunotherapy in patients with metastatic ovarian cancer.
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16

Josephs, Debra H., Heather J. Bax, Giulia Pellizzari, James F. Spicer, Ana Montes, and Sophia N. Karagiannis. Antibody Therapeutics for Ovarian Carcinoma and Translation to the Clinic. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0001.

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Despite improvements over the past decade in the treatment of ovarian cancer, many patients are at risk of recurrent disease and emerging drug resistance. The increased selectivity and reduced toxicity of molecularly targeted anti-cancer agents renders them attractive for development in ovarian cancer, and monoclonal antibodies targeting ovarian cancer-specific tumor antigens represent the largest such group investigated in this clinical setting. This chapter describes examples of monoclonal antibodies clinically evaluated for efficacy in ovarian cancer. These agents recognize molecular targets expressed on tumors or within tumor microenvironments that may be essential for tumor cell survival and proliferation. Recently, antibodies targeting checkpoint molecules on immune cells have shown efficacy in modulating anti-tumor immunity, and applications in ovarian carcinomas are evaluated. The chapter focuses on therapeutic agents’ attributes on targeting key cancer growth and progression pathways, and propensity to engender effector functions by activating immune effector cells in tumors and the circulation.
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17

A. Bulbul, Tuba Bulbul, V. Ozdemir, M.S. Akosman, Elmas Ulutas, and O. Yilmaz. Biphasic effect of nitric oxide on development of ovarian primordial and primary follicles in laying quail. Verlag Eugen Ulmer, 2015. http://dx.doi.org/10.1399/eps.2015.105.

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18

Lee, Gregory. Epitope/Peptide-Based Monoclonal Antibodies for Immunotherapy of Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0007.

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Two monoclonal antibodies, RP215 and GHR106, were selected, respectively, for the research and development of anti-cancer drugs targeting ovarian cancer and other types of human cancer. RP215 was shown to react with a carbohydrate-associated epitope located mainly in the variable regions of immunoglobulin heavy chains expressed on the surface of almost all cancer cells in humans. GHR106 was generated against a synthetic peptide corresponding to N1-29 amino acid residues in the extracellular domains of human GnRH receptor, which is surface-expressed by most cancer cells as well as the anterior pituitary. This monoclonal antibody was shown to serve as a bioequivalent analog to GnRH-derived decapeptides currently used clinically. The molecular mechanisms of action of these two antibody-based anti-cancer drug candidates were well elucidated following numerous biochemical, immunological, and molecular biological studies, mainly by using ovarian cancer as the model. Further preclinical studies with humanized forms of these two antibodies are essential.
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19

(Editor), Ian Jacobs, John Shepherd (Editor), David Oram (Editor), Tony Blackett (Editor), David Luelsey (Editor), Andy Berchuck (Editor), and Chris Hudson (Editor), eds. Ovarian Cancer: State of the Art and New Developments. 2nd ed. Oxford University Press, USA, 2001.

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20

Sills, Irene N., and Martin M. Fisher, eds. AM:STARs: Advances in the Treatment of Endocrine Disorders in Adolescents, Vol. 26, No. 2. American Academy of Pediatrics, 2015. http://dx.doi.org/10.1542/9781581109498.

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There are a series of endocrine disorders that can affect adolescents, some of which are related to growth and development and others that can occur at any age but may have specific implication for the adolescent age group. This issue provides a comprehensive update of endocrine issues seen in adolescents, with a focus on recent advances in diagnosis and treatment. Contents in Advances in the Treatment of Endocrine Disorders in Adolescents include Thyroid Disorders Update on Diabetes Melitus Disorders of Growth and Puberty Bone Health in Adolescents Polycystic Ovarian Syndrome Adrenal Disorders Lipid Disorders Endocrine Disorders in Pregnancy Endocrine Abnormalities in Patients with Eating Disorders Turner syndrome and Klinefelter Syndrome Disorders of Sex Development Endocrine Disorders in Adolescent Cancer Survivors
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21

S, Bartlett John M., ed. Ovarian cancer: Methods and protocols. Totowa, N.J: Humana Press, 2001.

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22

Hildebrandt, Thomas, and Ashley Heywood. Neurobiology of Eating Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0066.

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Eating disorders are recognized by a primary disturbance in eating that results in impairing levels of distress. Commonly beginning in adolescence and affecting primarily females, these illnesses have diagnostic criteria that are actively debated but retain core features including disturbances in the maintenance of a healthy weight, episodic binge eating and/or compensatory behaviors, and body image disturbances. This chapter will provide a summary of the primary neurobiological understanding of eating disorders form experiments using animal models as well as the growing literature in humans. Dysregulation in appetite hormones and peptides, adrenal hormones, ovarian hormones, the serotonergic and dopaminergic systems, and several central nervous system neurocircuits all show strong correlation to the development and maintenance of these chronic and frequently relapsing disorders.
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23

Katabuchi, Hidetaka, Takashi Ohba, and Takeshi Motohara. Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects. Springer, 2018.

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24

Katabuchi, Hidetaka, Takashi Ohba, and Takeshi Motohara. Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects. Springer, 2018.

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25

Drerup, Justin M., Curtis A. Clark, and Tyler J. Curiel. Clinical Trials of Ovarian Cancer Immunotherapy and Future Directions. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0013.

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Ovarian cancer (OC) is an immunogenic tumor and among the first where measures of anti-tumor immunity correlated with improved survival. Thus, immunotherapy could be a viable OC treatment modality. Nonetheless, clinical OC immunotherapy trials have demonstrated only modest successes at best, and there is currently no Food and Drug Administration (FDA)approved OC immune therapy despite recent successes in other carcinomas and lymphomas and FDA-approved immunotherapy agents for them. New data suggest specific impediments to effective de novo and treatment-induced anti-OC immunity and support the concept that effective, tolerable OC immunotherapy could be developed based on these newer insights. This chapter reviews the history of OC immunotherapy, highlights important discoveries in OC-related immune dysfunction, covers promising recent developments, highlights newer and ongoing clinical trials, and speculates on future directions that could lead to improved OC immunotherapy approaches.
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26

Deshpande, Rohini Rajendra. Immune system parameters associated with development of follicular cystic ovaries induced by neonatal estradiol injection. 1994.

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27

(Editor), Rocky S. Tuan, and Cecilia W. Lo (Editor), eds. Developmental Biology Protocols Volume 1 (Methods in Molecular Biology). Humana Press, 2000.

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28

(Editor), Rocky S. Tuan, and Cecilia W. Lo (Editor), eds. Developmental Biology Protocols Vol. 2 (Methods in Molecular Biology, 136) (Methods in Molecular Biology). Humana Press, 2000.

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29

Rijksuniversiteit te Utrecht. Faculteit der Diergeneeskunde., ed. The bovine oestrous cycle and pregnancy in vision. 2nd ed. [Boxmeer, The Netherlands: Intervet International BV, 1996.

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30

(Editor), A. R. Genazzani, F. Petraglia (Editor), G. D'Ambrogio (Editor), and P. G. Artini (Editor), eds. Recent Developments in Gynecology and Obstetrics: Selected Papers Presented at the 4th World Congress of Gynecological Endocrinology Organized by the International Society ... With the 2nd Congress of. Parthenon Publishing Group, 1996.

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31

Endocrine and metabolic disorders sourcebook: Basic consumer health information about hormonal and metabolic disorders that affect the body's growth, development, and functioning, including disorders of the pancreas, ovaries and testes, and pituitary, thyroid, parathyroid, and adrenal glands, with facts about growth disorders, addison disease, cushing syndrome, conn syndrome, diabetic disorders, multiple endocrine neoplasia, inborn errors of metabolism, and more along with information about endocrine functioning, diagnostic and screening tests, a glossary of related terms, and directories of additional resources. Detroit, MI: Omnigraphics, 2017.

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