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Journal articles on the topic 'Otogl'

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Author: Grafiati

Published: 25 May 2024

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1

Oonk, Anne M. M., Joop M. Leijendeckers, Patrick L. M. Huygen, Margit Schraders, Miguel del Campo, Ignacio del Castillo, Mustafa Tekin, et al. "Similar Phenotypes Caused by Mutations in OTOG and OTOGL." Ear and Hearing 35, no. 3 (2014): e84-e91. http://dx.doi.org/10.1097/aud.0000000000000008.

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2

Dubaissi, Eamon, Karine Rousseau, Gareth W. Hughes, Caroline Ridley, Richard K. Grencis, Ian S. Roberts, and David J. Thornton. "Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface." Proceedings of the National Academy of Sciences 115, no. 4 (January 8, 2018): 726–31. http://dx.doi.org/10.1073/pnas.1713539115.

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Mucosal surfaces represent critical routes for entry and exit of pathogens. As such, animals have evolved strategies to combat infection at these sites, in particular the production of mucus to prevent attachment and to promote subsequent movement of the mucus/microbe away from the underlying epithelial surface. Using biochemical, biophysical, and infection studies, we have investigated the host protective properties of the skin mucus barrier of the Xenopus tropicalis tadpole. Specifically, we have characterized the major structural component of the barrier and shown that it is a mucin glycoprotein (Otogelin-like or Otogl) with similar sequence, domain organization, and structural properties to human gel-forming mucins. This mucin forms the structural basis of a surface barrier (∼6 μm thick), which is depleted through knockdown of Otogl. Crucially, Otogl knockdown leads to susceptibility to infection by the opportunistic pathogen Aeromonas hydrophila. To more accurately reflect its structure, tissue localization, and function, we have renamed Otogl as Xenopus Skin Mucin, or MucXS. Our findings characterize an accessible and tractable model system to define mucus barrier function and host–microbe interactions.

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3

Barake, Rana, Samer Abou-Rizk, Georges Nemer, and Marc Bassim. "The OTOGL p.Arg925* Variant is Associated with Moderate Hearing Loss in a Syrian Nonconsanguineous Family." Genetic Testing and Molecular Biomarkers 21, no. 7 (July 2017): 445–49. http://dx.doi.org/10.1089/gtmb.2016.0406.

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4

Yariz, Kemal O., Duygu Duman, Celia Zazo Seco, Julia Dallman, Mingqian Huang, Theo A. Peters, Asli Sirmaci, et al. "Mutations in OTOGL , Encoding the Inner Ear Protein Otogelin-like, Cause Moderate Sensorineural Hearing Loss." American Journal of Human Genetics 91, no. 5 (November 2012): 872–82. http://dx.doi.org/10.1016/j.ajhg.2012.09.011.

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5

Gu, Xiaodong, Shan Sun, Luo Guo, Xiaoling Lu, Honglin Mei, Chuijin Lai, and Huawei Li. "Novel biallelic OTOGL mutations in a Chinese family with moderate non-syndromic sensorineural hearing loss." International Journal of Pediatric Otorhinolaryngology 79, no. 6 (June 2015): 817–20. http://dx.doi.org/10.1016/j.ijporl.2015.03.008.

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6

Colciago, Alessandra, Matteo Audano, Veronica Bonalume, Valentina Melfi, Tasnim Mohamed, Adam J. Reid, Alessandro Faroni, Peter A. Greer, Nico Mitro, and Valerio Magnaghi. "Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure." Cells 10, no. 7 (July 20, 2021): 1840. http://dx.doi.org/10.3390/cells10071840.

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Hearing loss (HL) is the most common sensory disorder in the world population. One common cause of HL is the presence of vestibular schwannoma (VS), a benign tumor of the VIII cranial nerve, arising from Schwann cell (SC) transformation. In the last decade, the increasing incidence of VS has been correlated to electromagnetic field (EMF) exposure, which might be considered a pathogenic cause of VS development and HL. Here, we explore the molecular mechanisms underlying the biologic changes of human SCs and/or their oncogenic transformation following EMF exposure. Through NGS technology and RNA-Seq transcriptomic analysis, we investigated the genomic profile and the differential display of HL-related genes after chronic EMF. We found that chronic EMF exposure modified the cell proliferation, in parallel with intracellular signaling and metabolic pathways changes, mostly related to translation and mitochondrial activities. Importantly, the expression of HL-related genes such as NEFL, TPRN, OTOGL, GJB2, and REST appeared to be deregulated in chronic EMF exposure. In conclusion, we suggest that, at a preclinical stage, EMF exposure might promote the transformation of VS cells and contribute to HL.

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7

Pan, Chen, Jun Li, Shixin Wang, Chen Shi, Yunmei Zhang, and Yafeng Yu. "Novel heterozygous mutations in the otogelin-like (OTOGL) gene in a child with bilateral mild nonsyndromic sensorineural hearing loss." Gene 808 (January 2022): 146000. http://dx.doi.org/10.1016/j.gene.2021.146000.

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8

Bonnet, C., M. Louha, N. Loundon, N. Michalski, E. Verpy, L. Smagghe, J. P. Hardelin, et al. "Biallelic nonsense mutations in the otogelin-like gene (OTOGL) in a child affected by mild to moderate hearing impairment." Gene 527, no. 2 (September 2013): 537–40. http://dx.doi.org/10.1016/j.gene.2013.06.044.

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9

Uran, Erik, Luka Fotović, Nikola Bedeković, Vladimir Stilinović, and Dominik Cinčić. "The Amine Group as Halogen Bond Acceptor in Cocrystals of Aromatic Diamines and Perfluorinated Iodobenzenes." Crystals 11, no. 5 (May 11, 2021): 529. http://dx.doi.org/10.3390/cryst11050529.

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In order to study the proclivity of primary amine groups to act as halogen bond acceptors, three aromatic diamines (p-phenylenediamine (pphda), benzidine (bnzd) and o-tolidine (otol)) were cocrystallised with three perfluorinated iodobenzenes (1,4-tetrafluorodiiodobenzene (14tfib), 1,3-tetrafluorodiiodobenzene (13tfib) and 1,3,5-trifluorotriiodobenzene (135tfib)) as halogen bond donors. Five cocrystals were obtained: (pphda)(14tfib), (bnzd)(13tfib)2, (bnzd)(135tfib)4, (otol)(14tfib) and (otol)(135tfib)2. In spite of the variability of both stoichiometries and structures of the cocrystals, in all the prepared cocrystals the amine groups form exclusively I···N halogen bonds, while the amine hydrogen atoms participate mostly in N–H⋯F contacts. The preference of the amine nitrogen atom toward the halogen bond, as opposed to the hydrogen bond (with amine as a donor), is rationalised by means of computed hydrogen and halogen bond energies, indicating that the halogen bond energy between a simple primary amine (methylamine) and a perfluorinated iodobenzene (pentafluoroiodobenze ne) is ca. 15 kJ mol−1 higher than the energy of the (H)NH∙∙∙NH2 hydrogen bond between two amine molecules.

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10

Skord, Virginia, and Barbara Ruch. "Mo Hitotsu no Chuseizo: Bikuni, Otogi Zoshi, Raisei." Monumenta Nipponica 47, no. 3 (1992): 393. http://dx.doi.org/10.2307/2385107.

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11

Issing, Peter R. "Präoperative Strahlentherapie bei therapeutischer Neck Dissection vielversprechend." Laryngo-Rhino-Otologie 97, no. 03 (March 2018): 157–58. http://dx.doi.org/10.1055/s-0044-100284.

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12

Volkenstein, Stefan. "Tympanoplastik Typ I im frühen Kindesalter erfolgsversprechend." Laryngo-Rhino-Otologie 97, no. 02 (February 2018): 84–85. http://dx.doi.org/10.1055/s-0043-123911.

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13

Reichenstein, Marek. "Assoziation von allergischer Rhinitis und Hypertonie untersucht." Laryngo-Rhino-Otologie 98, no. 02 (February 2019): 74–75. http://dx.doi.org/10.1055/a-0651-4041.

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Sakallioglu O et al. Allergic rhinitis and arterial blood pressure: a population-based study. J Laryngol Otol 2018; 132: 418–422 Gibt es einen Zusammenhang von allergischer Rhinitis und arteriellem Blutdruck sowie Bluthochdruck? In einer bevölkerungsbasierten Untersuchung wollten türkische Ärzte diese Frage klären.

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14

Schaaf, Helmut. "Morbus Menière – wie hilfreich ist die Magnetresonanztomografie?" Laryngo-Rhino-Otologie 97, no. 05 (May 2018): 300–301. http://dx.doi.org/10.1055/s-0043-121843.

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Patel VA et al. Magnetic resonance imaging findings in Ménière‘s disease. J Laryngol Otol 2017; 131: 602–607 Ein amerikanisches Wissenschaftlerteam veranschaulichte MRT-Befunde, die im Zusammenhang mit der Menière-Krankheit stehen. Diese umfassten kongenitale Malformationen, Schädigung der weißen Substanz, Veränderungen der hinteren Zirkulation und temporäre Abweichungen der Knochenstruktur.

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15

Lorenz, Kai J. "Helicobacter pylori siedelt gerne auf Mandel-Gewebe." Laryngo-Rhino-Otologie 96, no. 12 (December 2017): 822–23. http://dx.doi.org/10.1055/s-0043-119600.

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Siupsinskiene N et al. Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. J Laryngol Otol 2017; 131: 549–55 Wie häufig finden sich Helicobacter pylori Infektionen in den Gaumenmandeln und welcher Zusammenhang besteht zwischen H. pylori, den soziodemografischen Patientendaten und dem laryngopharyngealen Reflux?

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16

Hilger, Gregor. "Tinnitus oftmals mit temporomandibulärer Dysfunktion assoziiert." Laryngo-Rhino-Otologie 98, no. 11 (November 2019): 761. http://dx.doi.org/10.1055/a-0996-6580.

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Omidvar S et al. Association Between Tinnitus and Temporomandibular Disorders: A Systematic Review and Meta-Analysis. Ann Otol Rhinol Laryngol 2019; 128: 662–675 Tinnitus ist eines der häufigsten otologischen Symptome bei Patienten mit Kiefergelenkserkrankungen. Iranische Ärzte durchsuchten die Literatur, um den möglichen Zusammenhang zwischen Tinnitus und der temporomandibulären Dysfunktion (TMD) darzustellen.

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17

Gerstner, AOH. "Adenotonsillektomie: Umfrage zu Methoden und Befindlichkeiten der Operateure." Laryngo-Rhino-Otologie 98, no. 08 (August 2019): 530–31. http://dx.doi.org/10.1055/a-0898-8626.

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Kilavuz AE et al. Surgeons’ preferences and anxiety levels in paediatric adenotonsillectomy: European perspective. J Laryngol Otol 2019; 133: 333–338 Zur gleichzeitigen Entfernung von Gaumen- und Rachenmandeln gibt es verschiedene chirurgische Verfahren. Türkische HNO-Ärzte untersuchten, welche Verfahren Chirurgen für die Adenotonsillektomie präferieren und welche Angstzustände mit welchem Verfahren verbunden sind.

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18

Escalera-Balsera, Alba, Pablo Roman-Naranjo, and Jose Antonio Lopez-Escamez. "Systematic Review of Sequencing Studies and Gene Expression Profiling in Familial Meniere Disease." Genes 11, no. 12 (November 27, 2020): 1414. http://dx.doi.org/10.3390/genes11121414.

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Familial Meniere Disease (FMD) is a rare inner ear disorder characterized by episodic vertigo associated with sensorineural hearing loss, tinnitus and/or aural fullness. We conducted a systematic review to find sequencing studies segregating rare variants in FMD to obtain evidence to support candidate genes for MD. After evaluating the quality of the retrieved records, eight studies were selected to carry out a quantitative synthesis. These articles described 20 single nucleotide variants (SNVs) in 11 genes (FAM136A, DTNA, PRKCB, COCH, DPT, SEMA3D, STRC, HMX2, TMEM55B, OTOG and LSAMP), most of them in singular families—the exception being the OTOG gene. Furthermore, we analyzed the pathogenicity of each SNV and compared its allelic frequency with reference datasets to evaluate its role in the pathogenesis of FMD. By retrieving gene expression data in these genes from different databases, we could classify them according to their gene expression in neural or inner ear tissues. Finally, we evaluated the pattern of inheritance to conclude which genes show an autosomal dominant (AD) or autosomal recessive (AR) inheritance in FMD.

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19

Haxel, Boris. "Trimethoprim/Sulfamethoxazol bei Rhinosinusitis – erste vorläufige Resultate." Laryngo-Rhino-Otologie 97, no. 12 (December 2018): 832–33. http://dx.doi.org/10.1055/a-0677-5393.

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de Bonnecaze G et al. Functional outcome after long-term low-dose trimethoprim/sulfamethoxazole in chronic rhinosinusitis with purulence: a prospective study. J Laryngol Otol 2018; 132: 600–604 Trimethoprim/Sulfamethoxazol gilt als eine alternative Behandlungsoption der chronischen Rhinosinusitis. In einer prospektiven Studie wurden funktionelle und endoskopische Ergebnisse nach einer dreimonatigen Behandlung mit der niedrig dosierten Antibiotika-Kombination dokumentiert.

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20

Wilhelm, Thomas. "Unter welchen Bedingungen ist eine ambulante Tonsillektomie sicher?" Laryngo-Rhino-Otologie 97, no. 08 (August 2018): 525–26. http://dx.doi.org/10.1055/a-0621-2042.

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Morris S et al. Overnight in-hospital observation following tonsillectomy: retrospective study of post-operative intervention. J Laryngol Otol 2018; 132: 46–52 Die Sicherheit der ambulanten oder tagesklinischen Tonsillektomie ist gut dokumentiert. Allerdings existieren keine evidenzbasierten Leitlinien, die empfehlen, bei bestimmten Patienten keine ambulante Tonsillektomie auszuführen. Daher wollten australische Ärzte herausfinden, unter welchen Umständen eine ambulante Tonsillektomie als unsicher angesehen werden kann.

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21

Tisch, Matthias. "Fixationsoptionen des Receivers/Stimulators bei Cochlea-Implantation begutachtet." Laryngo-Rhino-Otologie 97, no. 11 (November 2018): 753–54. http://dx.doi.org/10.1055/a-0651-4028.

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Pamuk AE et al. The effect of cochlear implant bed preparation and fixation technique on the revision cochlear implantation rate. J Laryngol Otol 2018; 11:1–6 Zur Prävention einer Migration des Receivers/Stimulators bei der Cochlea-Implantation ist seine Einbettung entscheidend. Türkische Ärzte der Klinik für Hals-, Nasen- und Ohrenheilkunde der Universität von Istanbul verglichen zwei Techniken der Einbettung.

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22

Liu, Hui, Xiaoyu Song, and Rongrong Wang. "Quantitative Impacts of Climate Change and Human Activities on Grassland Productivity in Otog Banner, China from 2001 to 2020." Agronomy 13, no. 4 (April 17, 2023): 1140. http://dx.doi.org/10.3390/agronomy13041140.

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The responses of grassland net primary productivity (NPP) to climate change (CC) and human activities (HA) have received much attention and are inconsistent on different spatial scales. The accurate and quantitative evaluation of the impacts of CC and HA on grassland NPP at a county scale is very important to reveal the external driving factors on grassland NPP and guide the protection of the grassland ecosystem in the arid sandy area of China. In this study, the improved CASA model was adopted to quantify the grassland NPP in Otog Banner, China from 2001 to 2020. The spatiotemporal dynamics of grassland NPP and the relationships between grassland NPP and climate factors in space were analyzed using the methods of simple linear regression and relative sensitivity coefficient. Furthermore, the relative contributions to grassland NPP dynamics caused by CC and HA were explored using the quantitative method based on partial derivative. The results revealed that the mean value of grassland NPP was 175.17 g C m−2 yr−1, and exhibited a significant decrease trend periodically at a rate of 2.14 g C m−2 yr−1 from 2001 to 2020. The spatial distribution of grassland NPP increased from west to east gradually and ranged in 17.48–498.09 g C m−2 yr−1. Grassland NPP exhibited significant linear patterns along the gradients of climate factors, and was the most sensitive to sunshine duration (SSD). Approximately 86.83% of the grassland showed a degradation trend and 39.71% showed a serious degradation trend. The CC contribution to grassland NPP dynamics was 0.593 g C m−2 yr−1, and precipitation was the key driving climate factor, while the contribution of HA was −2.733 g C m−2 yr−1, which was the primary factor leading to large-scale degradation of grassland in Otog banner. This study indicates that the status of the grassland ecosystem in Otog Banner is not optimistic, and measures for grassland ecosystem restoration and improvement need to be further strengthened.

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23

Todt, Ingo. "Beurteilung der Tubenfunktionsstörung mit dem ETDQ-7." Laryngo-Rhino-Otologie 98, no. 02 (February 2019): 72–74. http://dx.doi.org/10.1055/a-0621-2000.

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Harju T et al. Eustachian Tube Dysfunction–Related Symptoms in Chronic Nasal Obstruction Caused by Inferior Turbinate Enlargement. Ann Otol Rhinol Laryngol 2017; 126: 798–803 Ärzte des Universitätskrankenhauses von Tampere, Finnland, beurteilten den Zusammenhang zwischen chronischer Nasenverstopfung durch Vergrößerung der unteren Nasenmuschel und Symptomen, die durch eine Eustachi-Tubendysfunktion bedingt sind, mit Hilfe des „Eustachian Tube Dysfunction Questionnaire“ (ETDQ-7) als Instrument zur Evaluation einer Tubenfunktionsstörung.

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24

Langer, Jörg. "Kinder- und Erwachsenen-Cholesteatom im Vergleich." Laryngo-Rhino-Otologie 48, no. 01 (January 2019): 9–10. http://dx.doi.org/10.1055/a-0677-5415.

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Jackson R et al. Cholesteatoma in children and adults: are there really any differences? J Laryngol Otol 2018; 132: 575–578 Das Cholesteatom gilt bei Kindern als aggressivere Läsion als bei Erwachsenen. Allerdings existieren nur wenige Studien, die die operativen Befunde und chirurgischen Ergebnisse zwischen diesen beiden Gruppen direkt verglichen haben. Britische Fachärzte für Otorhinolaryngologie bewerteten Unterschiede zwischen dem kindlichen- und dem Erwachsenen-Cholesteatom.

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25

Kleinjung, Tobias. "Zusammenhang zwischen Tinnituston und Frequenzbereich des Gehörverlusts." Laryngo-Rhino-Otologie 97, no. 04 (April 2018): 230–31. http://dx.doi.org/10.1055/s-0044-100277.

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Keppler H et al. The relationship between tinnitus pitch and parameters of audiometry and distortion product otoacoustic emissions. J Laryngol Otol 2017; 131: 1017–1025 Ein chronischer Tinnitus ist mit einem reduzierten akustischen Reiz assoziiert. Auf die Schädigung reagiert das zentrale Hörsystem mit Veränderungen. Den Zusammenhang zwischen Tinnituston und Parametern der Audiometrie sowie der distorsiv produzierten otoakustischen Emissionen (DPOAE) untersuchten Ärzte des Hör-Sprachzentrums der Universität der belgischen Stadt Gent.

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26

Jecker, Peter. "Mundhöhlenkarzinom: Optionen zum Erhalt der Unterkieferspeicheldrüse." Laryngo-Rhino-Otologie 97, no. 10 (October 2018): 666–68. http://dx.doi.org/10.1055/a-0651-4005.

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Cakir Cetin A et al. Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma. J Laryngol Otol 2018; 132: 446–451 Ärzte der medizinischen Fakultät der Universität in Izmir untersuchten Inzidenz und relevante Faktoren die mit der Beteiligung Unterkieferspeicheldrüse am Mundhöhlenkarzinom assoziiert sind. Insbesondere deswegen, um herauszufinden, ob in einem frühen Stadium des Plattenepithelkarzinoms der Mundhöhle die Möglichkeit besteht, die Unterkieferspeicheldrüse zu erhalten.

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27

Lehnerdt, Götz. "Erfolg einer endoskopischen Behandlung der strahlungsinduzierten Dysphagie." Laryngo-Rhino-Otologie 98, no. 07 (July 2019): 456–57. http://dx.doi.org/10.1055/a-0898-8526.

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Abu-Ghanem S et al. Endoscopic Management of Postradiation Dysphagia in Head and Neck Cancer Patients: A Systematic Review. Ann Otol Rhinol Laryngol 2019; doi: 10.1177/000348941983756 Im Rahmen einer Literaturrecherche untersuchten Ärzte der Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie der Stanford-Universität Erfolgsrate und das Sicherheitsprofil der zur Verfügung stehenden endoskopischen chirurgischen Optionen zur Behandlung einer strahlungsinduzierten Dysphagie bei Kopf- und Halskrebspatienten nach einer organerhaltenden Therapie.

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28

Simmler, Marie-Christine, Martine Cohen-Salmon, Aziz El-Amraoui, Laurent Guillaud, Jean-Claude Benichou, Christine Petit, and Jean-Jacques Panthier. "Targeted disruption of Otog results in deafness and severe imbalance." Nature Genetics 24, no. 2 (February 2000): 139–43. http://dx.doi.org/10.1038/72793.

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29

Palumbo, Pietro, Orazio Palumbo, Maria Pia Leone, Ester di Muro, Stefano Castellana, Luigi Bisceglia, Tommaso Mazza, Massimo Carella, and Marco Castori. "Compound Phenotype Due to Recessive Variants in LARP7 and OTOG Genes Disclosed by an Integrated Approach of SNP-Array and Whole Exome Sequencing." Genes 11, no. 4 (March 31, 2020): 379. http://dx.doi.org/10.3390/genes11040379.

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Neurodevelopmental disorders are a challenge in medical genetics due to genetic heterogeneity and complex genotype-phenotype correlations. For this reason, the resolution of single cases not belonging to well-defined syndromes often requires an integrated approach of multiple whole-genome technologies. Such an approach has also unexpectedly revealed a complex molecular basis in an increasing number of patients, for whom the original suspect of a pleiotropic syndrome has been resolved as the summation effect of multiple genes. We describe a 10-year-old boy, the third son of first-cousin parents, with global developmental delay, facial dysmorphism, and bilateral deafness. SNP-array analysis revealed regions of homozygosity (ROHs) in multiple chromosome regions. Whole-exome sequencing prioritized on gene-mapping into the ROHs showed homozygosity for the likely pathogenic c.1097_1098delAG p. (Arg366Thrfs*2) frameshift substitution in LARP7 and the likely pathogenic c.5743C>T p.(Arg1915*) nonsense variant in OTOG. Recessive variants in LARP7 cause Alazami syndrome, while variants in OTOG cause an extremely rare autosomal recessive form of neurosensorial deafness. Previously unreported features were acrocyanosis and palmoplantar hyperhidrosis. This case highlights the utility of encouraging technological updates in medical genetics laboratories involved in the study of neurodevelopmental disorders and integrating laboratory outputs with the competencies of next-generation clinicians.

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30

Geshi, Nobuo. "Development of the Middle Miocene Otoge volcanic complex, Shitara district, central Japan." Journal of the Geological Society of Japan 109, no. 10 (2003): 580–94. http://dx.doi.org/10.5575/geosoc.109.580.

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31

Hohenhorst, Winfried. "Epistaxis: was kann zum Tode führen?" Laryngo-Rhino-Otologie 98, no. 07 (July 2019): 457–58. http://dx.doi.org/10.1055/a-0854-7107.

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Integrate (The National ENT Trainee Research Network). Epistaxis and mortality. J Laryngol Otol 2018; 132: 1061–1066 Die Epistaxis ist einer der häufigsten ORL-Notfälle. In dem Programm: „Epistaxis 2016: National Audit of Management“ wurden prospektive Daten über 30 Tage zur standardisierten Versorgung einer Epistaxis durch die britische Gesellschaft für Otorhinolaryngologie gesammelt. Dabei wurde eine 30-tägige Gesamtmortalität von 3,4 % festgestellt. In einer Studie wurden Patienten, die während des Auditzeitraums verstarben, genauer untersucht.

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32

Neudert, Marcus. "Stapedotomie erfolgreich bei fortgeschrittener Otosklerose?" Laryngo-Rhino-Otologie 97, no. 06 (June 2018): 369–70. http://dx.doi.org/10.1055/s-0044-100282.

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Heining et al. Audiological outcome of stapes surgery for far advanced cochlear otosklerosis. J Laryngol Otol 2017; 131: 961–964 Die cochleäre Otosklerose ist eine seltene Erkrankung des Innenohres, die zu einer Verknöcherung der Haarzellen führt und die Homöostase der Lymphströme negativ beeinflussen kann. Betroffene leiden unter Innenohrschwerhörigkeit, eine Therapie gilt als schwierig. Heining und Kolleginnen/Kollegen haben nun in einer retrospektiven Studie untersucht, ob Patienten mit fortgeschrittener Otosklerose von einer Stapedotomie profitieren können.

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33

Schaaf, Helmut. "Hörgesundheit: lärminduzierter Hörverlust droht bei häufiger Lärmexposition." Laryngo-Rhino-Otologie 98, no. 03 (March 2019): 144–46. http://dx.doi.org/10.1055/a-0785-0918.

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Hussain T et al. Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices. Ann Otol Rhinol Laryngol 2018; 127: 703–709 Tragbare Medienabspielgeräte haben eine enorme Anziehungskraft entwickelt, nicht zuletzt durch die Einführung des iPod von Apple im Jahr 2001. Die Integration solcher Abspielgeräte in Mobiltelefone hat ihre Verwendung insbesondere bei jungen Erwachsenen weiter erhöht, was Anlass zur Besorgnis hinsichtlich schädlicher Auswirkungen auf das Gehör gibt.

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34

Kapsreiter, Markus. "Supraglottiskarzinom: Erfahrungen mit der transoralen Roboter-Chirurgie." Laryngo-Rhino-Otologie 98, no. 03 (March 2019): 143–44. http://dx.doi.org/10.1055/a-0785-1003.

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Karabulut B et al. Comparison of functional and oncological treatment outcomes after transoral robotic surgery and open surgery for supraglottic laryngeal cancer. J Laryngol Otol 2018; 132: 832–836 Die Behandlungsmöglichkeiten eines Supraglottiskarzinoms umfassen offene Supraglottis-Laryngektomie, transorale Lasertherapie, transorale Roboterchirurgie und Chemotherapie. Ärzte der HNO-Klinik des Ümraniye-Krankenhauses in Istanbul verglichen die Behandlungsergebnisse bei Patienten mit supraglottischen Tumoren des Larynxkarzinoms, die mittels einer transoralen robotischen Laryngektomie und einer offenen Laryngektomie behandelt wurden.

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Diensthuber, Marc. "Schonende Operationstechnik beim Attikcholesteatom vielversprechend." Laryngo-Rhino-Otologie 97, no. 07 (July 2018): 449–50. http://dx.doi.org/10.1055/a-0588-9272.

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Presutti L et al. The Impact of the Transcanal Endoscopic Approach and Mastoid Preservation on Recurrence of Primary Acquired Attic Cholesteatoma. Otol Neurotol 2018; 39: 445–450 Die chirurgische Behandlung eines Attikcholesteatoms ist anspruchsvoll und über eine optimale Strategie wird aktuell immer noch diskutiert. Wissenschaftler haben nun untersucht, welche Faktoren einen Einfluss auf postoperative Erkrankungen eines primär erworbenen Attikcholesteatoms haben. Die Autoren nahmen an, dass minimalinvasiv, schleimhautschonende Operationstechniken einen positiven Effekt auf die Ergebnisse in Bezug auf Rezidive haben.

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Issing, Peter R. "Ambulante Cochlea-Implantation: was führt zur stationären Aufnahme?" Laryngo-Rhino-Otologie 97, no. 10 (October 2018): 664–65. http://dx.doi.org/10.1055/a-0651-3971.

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Patel TA et al. Clinical Indicators of Admission for Pediatric Cochlear Implant Procedures. Ann Otol Rhinol Laryngol 2018; 127: 470–474 Eine ambulante Cochlea-Implantation bei Kindern gilt als sicher. Allerdings wird eine Minderheit über Nacht stationär aufgenommen. In Studien wird nahezu ausschließlich über postoperative Komplikationen und Behandlungsergebnisse und kaum über prognostische Indikatoren des Outcomes berichtet. Daher suchten amerikanische HNO-Ärzte nach Parametern, die mit der stationären Aufnahme korrelieren und prüften die Auswirkungen auf das klinische Ergebnis.

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Seidel, David Ulrich. "Lebensqualität mit Stimmprothese nach totaler Laryngektomie." Laryngo-Rhino-Otologie 97, no. 12 (December 2018): 829–32. http://dx.doi.org/10.1055/a-0651-3983.

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Patel RS et al. Tracheoesophageal Prosthesis Use Is Associated With Improved Overall Quality of Life in Veterans With Laryngeal Cancer. Ann Otol Rhinol Laryngol 2018; 127: 421–428 Etwa 20 000 Menschen erkranken jährlich an einem Larynxkarzinom (LASCC) in den USA. Die totale Laryngektomie gilt als Standard in der Behandlung, aber die onkologischen und funktionellen Ergebnisse sind wenig erforscht. Amerikanische Chirurgen haben den Langzeiteffekt der tracheoösophagealen Punktion und Einsetzung einer Stimmprothese auf die Lebensqualität bei Veteranen untersucht.

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Lautermann, Jürgen. "Inzidenz des Glottiskarzinoms bei jungen Patienten." Laryngo-Rhino-Otologie 98, no. 08 (August 2019): 531–32. http://dx.doi.org/10.1055/a-0898-8551.

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Bayan S et al. Glottic Carcinoma in Young Patients. Ann Otol Rhinol Laryngol 2019; 128: 25S–32S In jüngster Zeit mehren sich die Hinweise, dass Stimmbandkarzinome ähnlich wie Oropharynxkarzinome öfter bei nicht rauchenden Patienten mit HPV-Infektionen auftreten. Darüber hinaus gibt es Beobachtungen, die zeigen, dass Glottiskarzinom-Patienten wohl jünger sind als in der Vergangenheit angenommen. HNO-Ärzte der Universität von Chicago bestimmten daher die Inzidenz des Glottiskarzinoms bei Patienten im Alter von 30 Jahren oder jünger.

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HUANG, Senbiao, Xiaoye MA, Haiquan GUO, Xuepeng QIU, and Lianxun GAO. "Mechanical Properties, Morphology and Structure of BPDA /PPD /OTOL Polyimide Fibers." Acta Agronomica Sinica 29, no. 8 (2012): 863. http://dx.doi.org/10.3724/sp.j.1095.2012.00386.

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DOĞAN AVERBEK, Güler. "FEDAYÎ MEHMED DEDE, MANTIK-I ESRÂR ADLI MANZUM MANTIKU'T-TAYR TERCÜMESİ VE OTOGR." International Journal Of Turkish Literature Culture Education 6, no. 6/3 (January 1, 2017): 1490–506. http://dx.doi.org/10.7884/teke.3998.

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Schwemmle, Cornelia. "Penetration/Aspiration bei gesunden Erwachsenen: ein unterschätztes Phänomen?" Laryngo-Rhino-Otologie 97, no. 09 (September 2018): 601–2. http://dx.doi.org/10.1055/a-0621-2095.

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Butler SG et al. Aspiration as a Function of Age, Sex, Liquid Type, Bolus Volume, and Bolus Delivery Across the Healthy Adult Life Span. Ann Otol Rhinol Laryngol 2018; 127: 21–32 Mittels funktioneller endoskopischer Schluck-Untersuchung (FEES) wurden Faktoren bestimmt, die im Verlauf des Erwachsenenlebens das Eindringen und die Aspiration während des Schluckens beeinflussen. Die amerikanischen HNO-Ärzt/innen vermuteten, dass bei gesunden Älteren ein höherer Fettgehalt in Flüssigkeiten, das Bolusvolumen, die Aufnahme mit einem Strohhalm, fortgeschrittenes Alter und männliches Geschlecht das Aspirationsrisiko erhöht.

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Bott, Raymond C., Peter C. Healy, and Graham Smith. "Evidence for Au(I)…Au(I) Interactions in a Sterically Congested Environment: Two-Coordinate Gold(I) Halide Phosphine Complexes." Australian Journal of Chemistry 57, no. 3 (2004): 213. http://dx.doi.org/10.1071/ch03172.

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Two-coordinate tris(2-methylphenyl)phosphine and tris(4-methylphenyl)phosphinegold(I) halide complexes, [AuP(otol)3X], [AuP(ptol)3X], where X = Cl, Br, and I, have been crystallized from dimethylformamide and characterized by single-crystal X-ray structure determinations. The P(otol)3 structures comprise an isomorphous series distinct from the previously published chloride, crystallizing with two independent molecules in the asymmetric unit in the space group Pbca, with a ≈ 20.0, b ≈ 28.0, c ≈ 14.0 Å. The molecules associate to form dimers through a back-to-back sextuple phenyl embrace (6PE). The P(ptol)3 complexes are isomorphous with the previously published chloride, crystallizing with two independent molecules in the unit cell in the space group P21/c, with a ≈ 10.0, b ≈ 22.0, c ≈ 19.5 Å, β ≈ 99°. The molecules associate through edge-to-face interactions along the direction of the a-axis. Preparation of the chloride by anodic dissolution of gold in an acetonitrile solution of the ligand and aqueous HCl yields a new polymorph, crystallizing in the space group Aba2, with a 19.738(2), b 11.813(3), c 17.645(1) Å. Despite the bulkiness of the phosphine ligand, this form of [AuP(ptol)3Cl] exhibits a short intermolecular Au…Au contact distance of 3.375(1) Å, indicative of a significant aurophilic interaction. The ranges for the Au—P, Au—Cl, Au—Br, Au—I bond lengths and P—Au—X bond angles in the series are: 2.201(3)–2.265(4), 2.255(3)–2.290(4), 2.388(2)–2.411(2), 2.542(1)–2.556(2) Å, and 173.2(2)–179.6(1)° respectively.

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Shen, Dexing, Zongquan Wu, Jiang Liu, Lixiao Wang, Sangkug Lee, Frank W. Harris, Stephen Z. D. Cheng, John Blackwell, Tzongming Wu, and Sergei Chvalun. "High-Performance Aromatic Polyimide Fibres. 4. A Copolymer Fibre Containing BPDA-OTOL-PPD (100/70/30)." Engineering Plastics 2, no. 3 (January 1994): 147823919400200. http://dx.doi.org/10.1177/147823919400200301.

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A copolyimide has been synthesized from 3,3',4,4′-tetracarboxybiphenyl dianhydride (BPDA), 3,3′-dimethyl-4,4′-diaminobiphenyl (OTOL) and p-phenylene diamine (PPD) in a mole ratio of 100/70/30 through a one-step polymerization at elevated temperature. It has been spun as fibres by dry-jet wet spinning. The tensile modulus of the fibres reaches 120 GPa, with a tensile strength of 3.2 GPa. Such high tensile properties are the result of the high draw ratio (up to x8) while annealing at 400°C. The homopolyimide (BPDA-OTOL) is found to adopt a triclinic crystal lattice, based on wide angle X-ray and electron diffraction experiments. In the copolyimide, it's crystal lattice is disturbed by the introduction of the PPD comonomer. As the draw ratio of the copolymer fibre is increased, the crystallinity, overall orientation and the apparent axial crystallite sizes also increased, as evidenced by wide angle X-ray diffraction, optical birefringence and density measurements. These structural developments critically affect the tensile properties of the fibres. The glass transition temperature of the copolyimide is 308°C, based on thermal mechanical measurements. Dimensional stability is retained up to about 300°C. At around 100–250°C, a subglass transition is observed in dynamic mechanical measurements, and is assigned as a β relaxation. The activation energy of this relaxation is 140 hJ/mol, based on its frequency dependence. The α relaxation corresponds to the glass transition. As the crystallinity increases with drawing, this relaxation is suppressed due to the restriction of molecular segmental motion.

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Shen, Dexing, Zongquan Wu, Jiang Liu, Lixiao Wang, Sangkug Lee, Frank W. Harris, Stephen Z. D. Cheng, John Blackwell, Tzongming Wu, and Sergei Chvalun. "High-Performance Aromatic Polyimide Fibres. 4. A Copolymer Fibre Containing BPDA-OTOL-PPD (100/70/30)." Polymers and Polymer Composites 2, no. 3 (March 1994): 149–58. http://dx.doi.org/10.1177/096739119400200301.

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A copolyimide has been synthesized from 3,3',4,4′-tetracarboxybiphenyl dianhydride (BPDA), 3,3′-dimethyl-4,4′-diaminobiphenyl (OTOL) and p-phenylene diamine (PPD) in a mole ratio of 100/70/30 through a one-step polymerization at elevated temperature. It has been spun as fibres by dry-jet wet spinning. The tensile modulus of the fibres reaches 120 GPa, with a tensile strength of 3.2 GPa. Such high tensile properties are the result of the high draw ratio (up to x8) while annealing at 400°C. The homopolyimide (BPDA-OTOL) is found to adopt a triclinic crystal lattice, based on wide angle X-ray and electron diffraction experiments. In the copolyimide, it's crystal lattice is disturbed by the introduction of the PPD comonomer. As the draw ratio of the copolymer fibre is increased, the crystallinity, overall orientation and the apparent axial crystallite sizes also increased, as evidenced by wide angle X-ray diffraction, optical birefringence and density measurements. These structural developments critically affect the tensile properties of the fibres. The glass transition temperature of the copolyimide is 308°C, based on thermal mechanical measurements. Dimensional stability is retained up to about 300°C. At around 100–250°C, a subglass transition is observed in dynamic mechanical measurements, and is assigned as a β relaxation. The activation energy of this relaxation is 140 hJ/mol, based on its frequency dependence. The α relaxation corresponds to the glass transition. As the crystallinity increases with drawing, this relaxation is suppressed due to the restriction of molecular segmental motion.

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Roman-Naranjo, Pablo, Alvaro Gallego-Martinez, Andrés Soto-Varela, Ismael Aran, Maria del Carmen Moleon, Juan Manuel Espinosa-Sanchez, Juan Carlos Amor-Dorado, Angel Batuecas-Caletrio, Paz Perez-Vazquez, and Jose Antonio Lopez-Escamez. "Burden of Rare Variants in the OTOG Gene in Familial Meniere’s Disease." Ear & Hearing 41, no. 6 (April 2, 2020): 1598–605. http://dx.doi.org/10.1097/aud.0000000000000878.

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ZENG, Nanshi, Eiji IZAWA, Koichiro WATANABE, and Tetsumaru ITAYA. "Timing of Au-Ag mineralization and related volcanism at Otoge, Yamagata Prefecture, Northeast Japan." JOURNAL OF MINERALOGY, PETROLOGY AND ECONOMIC GEOLOGY 91, no. 8 (1996): 297–304. http://dx.doi.org/10.2465/ganko.91.297.

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Franco, Diana L., Sameer R. Islam, Dora M. Lam-Himlin, David E. Fleischer, and Shabana F. Pasha. "Presentation, Diagnosis, and Management of Esophageal Lichen Planus: A Series of Six Cases." Case Reports in Gastroenterology 9, no. 2 (July 22, 2015): 253–60. http://dx.doi.org/10.1159/000437292.

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Lichen planus (LP) is an idiopathic disorder that presents with cutaneous and genital manifestations. Esophageal LP (ELP) was first described by Al-Shihabi and Jackson [J Laryngol Otol 1982;96:567-571] in 1982. Only approximately 80 cases have been documented in the literature since. It is a rare and underrecognized disorder, leading to a delay in diagnosis and a lack of standardized management. We describe the presentation, diagnosis, and management of 6 cases of ELP, at a tertiary institution, because we believe that an increasing awareness of this condition can help identify more cases and increase our understanding of this interesting condition.

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Баттулга, Цэнд. "Арвасын уулын Харанхуйн хөндийн руни бичээс." Mongolian Journal Anthropology, Archaeology and Ethnology 12, no. 1 (December 29, 2023): 94–102. http://dx.doi.org/10.22353/mjaae.2023120109.

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The runic inscriptions found on Arvas mountain in the Urandösh town of Üzüür city, Otog county, Ordos, Inner Mongolia Autonomous Region, China, were the subject of the research we conducted and readings in this article. In the Kharankhui Valley of Arvas Mountain, there are three pieces of runic inscriptions. The earliest, and most obvious, inscription was recorded in 2012, although researchers have just recently become aware of it. Content-wise, the first inscription is the note of travel, and the second and third are dedicated to his father. But it falls under the category of carved inscriptions in terms of writing technique.

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TAKADA, Akira. "Structure of a cauldron in the Otoge Ring Complex, Shitara district, Aichi Prefecture, central Japan." Journal of the Geological Society of Japan 93, no. 2 (1987): 107–20. http://dx.doi.org/10.5575/geosoc.93.107.

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Askari, Masomeh, Zahra Moradi, Mahsa Mohammadi, Milad Lagzian, and Samira Asgharzade. "Prediction and interpretation of rare missense variant in OTOG associated with hearing loss." Genomics 113, no. 4 (July 2021): 2793–99. http://dx.doi.org/10.1016/j.ygeno.2021.06.012.

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