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Relevant bibliographies by topics / Osteoporotic fractures

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Academic literature on the topic 'Osteoporotic fractures'

Author: Grafiati

Published: 4 June 2021

Last updated: 24 January 2023

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Journal articles on the topic "Osteoporotic fractures"

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Ahn, Seong Hee, Seongbin Hong, Young J. Suh, Da Hea Seo, Yujin Jeong, Yongin Cho, and So Hun Kim. "ODP087 Dose-dependent effect of long-term statin use on risk of osteoporotic fracture in elderly patients." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A162. http://dx.doi.org/10.1210/jendso/bvac150.331.

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Abstract Introduction Studies have been conducted to assess the association between the use of statin and risk of new onset osteoporosis or osteoporotic fractures, however, they have shown conflicting results. We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in elderly population. Methods In this population cohort study with Korean National Health Insurance Service-Senior Cohort database, a total of 365,656 elderly (≥60 years) without previous history of osteoporosis were included. The patients who did not have a history of statin use in year 2003 were followed from January 2004 to December 2012. Incidences of major osteoporotic fractures and site specific fractures were compared using the Cox proportional hazards model with use the inverse probability weighting method. Results During years follow-up period, 54,959 major osteoporotic fractures occurred; the risk of major osteoporotic fractures was significantly reduced (OR,0.769; 95% CI,0.716-0.826) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for both vertebral fracture (OR,0.701; 95% CI,0.641-0.767) and non-vertebral fracture (OR,0.807; 95% CI,0.726-0.898). Longer duration and higher cumulative dose of statin, defined by cumulative daily defined dose, were negatively associated with the risk of major osteoporotic fracture. Conclusion In this population-based cohort study, the use of statin was associated with significant reduction in the risk of osteoporotic fractures in elderly patients without previous history of osteoporosis. Presentation: No date and time listed

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Watts, Nelson B. "Osteoporotic vertebral fractures." Neurosurgical Focus 10, no. 4 (April 2001): 1–3. http://dx.doi.org/10.3171/foc.2001.10.4.13.

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Osteoporosis is a significant public health problem. Vertebral fractures are the most common fracture in patients with osteoporosis, occurring in approximately 750,000 cases each year. The fractures may cause acute or chronic pain, reduce the quality of life, and shorten life expectancy. Several medications are available that reduce the risk of fracture. Vertebroplasty and kyphoplasty (balloon-inflated expansion of collapsed vertebrae followed by injection of bone cement) may reduce or relieve pain in selected patients. Although surgery is rarely necessary for the management of osteoporotic vertebral fractures, it may be indicated for other reasons. No studies have been conducted to determine if the outcome of spinal fusion is different in patients with osteoporosis and, if it is, whether management of the patient's osteoporosis will improve the outcome.

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Lyalina, V. V., I. A. Borshenko, S. V. Borisovskaya, E. A. Skripnichenko, R. V. Binyakovskiy, V. V. Trishina, and I. G. Nikitin. "Acute Osteoporotic Vertebral Fracture. Part 1. Definitions, Clinical Presentation, Pain Assessment, Diagnostic Imaging, Introduction to Differential Diagnosis." Russian Archives of Internal Medicine 12, no. 4 (July 30, 2022): 254–66. http://dx.doi.org/10.20514/2226-6704-2022-12-4-254-266.

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Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.

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Lyalina, V. V., I. A. Borshenko, S. V. Borisovskaya, E. A. Skripnichenko, R. V. Binyakovskiy, V. D. Solomin, V. V. Trishina, and I. G. Nikitin. "Acute Osteoporotic Vertebral Fracture. Part 2. Differential Diagnostics According to the Data of Imaging Methods. Conservative and Surgical Treatment." Russian Archives of Internal Medicine 12, no. 6 (November 29, 2022): 438–49. http://dx.doi.org/10.20514/2226-6704-2022-12-6-438-449.

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Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.

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Oh, Ho-Seok, Sung-Kyu Kim, and Hyoung-Yeon Seo. "Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017." Healthcare 9, no. 3 (March 14, 2021): 324. http://dx.doi.org/10.3390/healthcare9030324.

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To investigate the incidence and characteristics of osteoporosis and osteoporotic fractures in Korea, we used the Health Insurance Review and Assessment Service (HIRA) database. Patients over 50 years old, who were diagnosed or treated for osteoporosis and osteoporotic fractures in all hospitals and clinics, were analyzed between 1 January 2009 and 31 December 2017 by using the HIRA database that contains prescription data and diagnostic codes. These data were retrospectively analyzed by decade and age-specific and gender-specific incidents in each year. We also evaluated other characteristics of patients including medication state of osteoporosis, primary used medical institution, regional-specific incidence of osteoporosis, and incidence of site-specific osteoporotic fractures. The number of osteoporosis patients over 50 years old, as diagnosed by a doctor, steadily increased from 2009 to 2017. The number of osteoporosis patients was notably greatest in the 60′s and 70′s age groups in every study period. Patients undergoing treatment for osteoporosis increased significantly (96%) from 2009 to 2017. Among the patients diagnosed with osteoporosis, the proportion who experienced osteoporotic fracture increased gradually (60%) from 2009 to 2017. The number of patients with osteoporotic fractures of the spine and hip was highest in the 70 to 90 age range, and the number of patients with osteoporotic fractures in the upper and lower extremities was highest in the 50 to 70 age range. Understanding the trends of osteoporosis in Korea will contribute to manage the increased number of patients with osteoporosis and osteoporotic fractures.

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Romanov, G. N., N. F. Chernova, T. I. Moskvicheva, and E. V. Rudenko. "CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF REPEATED OSTEOPOROTIC FRACTURES IN PATIENTS OF GOMEL REGION OF BELORUSSIA AND MODERN THERAPEUTIC STRATEGY." Osteoporosis and Bone Diseases 17, no. 2 (December 15, 2014): 22–25. http://dx.doi.org/10.14341/osteo2014222-25.

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Introduction. Experienced osteoporotic fractures are a significant predictor of repeated, more severe fractures, entailing reduced quality of life and its expectancy. Objectives. To study the clinical and instrumental data of patients with single and repeated osteoporotic fractures of the forearm, proximal femur and spine, as well as the frequency of their occurrence in women of Gomel region of Belorussia. Materials and methods. The study included 2356 women aged over 50 years. Protocol included questionnaire with the assessment of detailed fracture data, medical history and Charlson comorbidity index calculation, quantitative assessment of bone mineral density (BMD) by dual-energy X-ray absorptiometry (LUNAR Prodigy, GE, USA). Results. Osteoporotic fractures of the forearm, spine and proximal femur were found in 523 (22%) of women. More than one fracture was revealed in 106 patients of the total number of patients with fractures (20%). The average age of first fracture in patients with multiple fractures was 59.9 years, for second fracture - 63.3 years and for the third fracture - 66.6 years. Most repeated fractures (67%) occurred within the first three years from the time of initial fracture and were not associated with the densitometry data. Despite the presence of multiple osteoporotic fractures, adequate specific therapy of severe osteoporosis was recommended to only every third patient in need of treatment. Conclusions. Every fifth woman over the age of 50 years had experienced an osteoporotic fracture, with the highest risk of re-fracture occurring during the first three years. Mandatory antiosteoporotic therapy is the only effective method of secondary prevention of complications of osteoporosis.

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Czerwiński, Edward, Jarosław Czubak, Marek Synder, Maja Warzecha, and Małgorzata Berwecka. "Contemporary Management of Osteoporotic Fractures." Ortopedia Traumatologia Rehabilitacja 20, no. 2 (April 16, 2018): 91–102. http://dx.doi.org/10.5604/01.3001.0011.7665.

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With aging of the population, osteoporotic fractures are becoming an increasing medical problem worldwide. It has been estimated that 2,700,000 patients experienced a low energy fracture in the Polish population in 2010. On the basis of contemporary world standards and publications in the field of orthopaedics and traumatic surgery, a summary of the principles of management of osteoporotic fractures is presented. Both general problems of fracture treatment in elderly patients as well as difficulties in surgical and conservative treatment resulting from osteoporotic bone abnormalities are discussed. Special attention is paid to preoperative and postoperative procedures in patients with proximal femur fractures. Also presented is a contemporary strategy for the treatment of fractures of the distal forearm, proximal humerus and vertebrae. General principles of diagnosis and treatment of osteoporosis are discussed.

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Muratore, Maurizio, Francesco Conversano, Maria Daniela Renna, Paola Pisani, Valeria Villani, and Sergio Casciaro. "Social Impact of Osteoporotic Fractures." International Journal of Measurement Technologies and Instrumentation Engineering 4, no. 2 (April 2014): 39–53. http://dx.doi.org/10.4018/ijmtie.2014040104.

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Osteoporosis affects about 200 million subjects in the world and is responsible for 8.9 million fractures each year. The frequency of osteoporotic fractures is rising in many countries, due to the increased longevity of the population. In Europe, the annual cost of all osteoporotic fractures has been estimated to be 30 billion of Euros. In this paper, after an overview of the socioeconomic impact of osteoporosis in the world and in Italy, with particular focus on Apulia region, the most important techniques used to assess the fracture risk are briefly described. Moreover, the most commonly used pharmacological agents for the treatment of osteoporosis are reported. The aim of this review is to analyze the main factors causing the huge impact of osteoporosis on healthcare system, in terms of diagnosis and therapies, and to illustrate recent advances for treatment and prevention of this “silent disease”.

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Povoroznyuk, V. V., H. Johansson, N. V. Grygorieva, J. A. Kanis, А. S. Musiіenko, M. Lorentzon, N. C. Harvey, E. V. McCloskey, and E. Liu. "Ukrainian FRAX version in the male osteoporosis management." PAIN, JOINTS, SPINE 11, no. 2 (July 20, 2021): 53–61. http://dx.doi.org/10.22141/2224-1507.11.2.2021.236563.

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Background. At present, FRAX is a well-known and widely-used risk assessment tool for major osteoporotic fractures. The Ukrainian version of the FRAX algorithm was presented in 2016; with the “intervention threshold” for additional DXA examination and antiosteoporotic treatment of the Ukrainian women published in 2019. However, the data on its possible uses in men are limited. The purpose of the study was to evaluate the possibilities of using the previously developed criteria of the Ukrainian FRAX algorithm in Ukrainian men. Materials and methods. We examined 653 outpatients aged 40–88 years (mean age (M ± SD) — 60.5 ± 11.8 years). We analyzed the results both in the general group and in the age subgroups; in particular, with an account of low-trauma fractures, included in the FRAX calculation, and compared them with the corresponding indices of the Ukrainian women. Results. The most frequent (26.6 %) risk factor for osteoporotic fractures in the group of Ukrainian men was a history of low-trauma fracture (the corresponding index in women was 51.3 %), its presence being the reason for antiosteoporotic treatment initiating. Following upon the risk of major osteoporotic fractures calculated by FRAX, only 6.7 % of men without previous fractures were found to require additional DXA examination in order to re-evaluate the osteoporotic fracture risk, and none had a high fracture risk. 73 % of men without fractures did not have any risk factor included in the FRAX algorithm. Conclusions. This study showed a greater need for both antiosteoporotic treatment without DXA assessment and additional densitometric examination for the osteoporotic fracture risk assessment for the Ukrainian women rather than men, along with a special attention to the presence of previous fractures in men, and consideration of other risk factors for osteoporosis, even those not included in this FRAX algorithm.

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Möckel, Luis. "Number and Impact of Osteoporotic Forearm Fractures: An Analysis of German Hospital Data." Osteologie 29, no. 02 (May 2020): 150–56. http://dx.doi.org/10.1055/a-1023-4859.

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Abstract Introduction Osteoporosis is a burden for Germany, however recent data on osteoporotic forearm fractures is missing. Methods Numbers of hospital diagnosed forearm fractures based on ICD-10 code S52.- for 2000 to 2017 were taken from GBE database. From this dataset, number of osteoporotic forearm fractures in patients aged 50+ years were calculated using age- and gender specific weighting factors. In addition, fracture rates per 100,000 people, total days in hospital and quality-adjusted life years (QALYs) lost due to osteoporotic forearm fractures were calculated. Results In 2017, a total of 69,046 osteoporotic forearm fractures were diagnosed in hospitals in patients aged 50+ years in Germany, which represents an increase of 48.8% since 2000. Age-adjusted fracture rates in women were 300/100,000 (standard error [SE] 1.25) in 2017 compared to 248/100,000 (SE 1.25) in 2000 (Odds ratio [OR]: 1.21 [95% confidence interval [CI]: 1.02; 1.43]; p = 0.026). In male patients fracture rates were 62/100,000 (SE 0.61) in 2017 and 53/100,000 (SE 0.65) in 2000 (OR: 1.17 [95% CI: 0.81; 1.69]; p = 0.401). However, highest numbers and rates of osteoporotic forearm fractures were seen in 2010.Osteoporotic forearm fractures resulted in 276,185 hospital days and 2,259 lost QALYs in patients aged 50+ years in 2017. Conclusion Number of osteoporotic forearm fractures increased from 2000 to 2017 in Germany and indicate a high burden of disease for patients and healthcare system.

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Dissertations / Theses on the topic "Osteoporotic fractures"

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Kaptoge, Stephen Kipkemoi. "Epidemiology of risk factors for osteoporosis and osteoporotic fractures." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615203.

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Misra, Devyani. "Warfarin use and risk of osteoporotic fractures." Thesis, Boston University, 2012. https://hdl.handle.net/2144/21219.

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Thesis (M.S.M.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
OBJECTIVE: Prior studies examining the association of warfarin use and osteoporotic fractures have found conflicting results and have had methodological problems, such as confounding by indication and confounding by duration of warfarin use. Thus, we studied the association of warfarin use with fractures at the hip, spine and wrist, among older men and women with atrial fibrillation recruited from the general population, using rigorous statistical tools to overcome challenges faced by prior studies. METHODS: We included men and women ≥65 years with incident atrial fibrillation, without history of fracture, followed between 2000-2010 from The Health Improvement Network (THIN). Long-term warfarin use was defined in two ways: 1) warfarin use ≥ 1year; 2) warfarin use ≥3 years. Non-use was defined as no use of warfarin over the follow-up period. Propensity scores (PS) for warfarin use were calculated using logistic regression with long-term use of warfarin as the dependent variable and age, sex, body mass index (BMI), history of multiple falls, deep venous thrombosis, pulmonary embolism, heart failure, neuropsychiatric impairment, hyperthyroidism, estrogen use, beta blockers, corticosteroids, bisphosphonates, smoking and alcoholism as independent variables. Each warfarin user was then matched by PS to a non-user by the “greedy matching” method. Incidence rates were calculated for warfarin users and non-users. The association between long-term warfarin use and risk of hip, spine and wrist fractures was evaluated using Cox-proportional hazards models. RESULTS: Incidence rates of hip fracture were 5.21 and 6.20 per 1000 person-years among subjects with warfarin use >1 (n=20,346) and >3 (n=11,238) years, respectively. The hazard ratios of hip fracture for warfarin use >1 and >3 years were 1.08 (95% CI 0.87, 1.35) and 1.13 (95% CI: 0.84, 1.5), respectively. Similar findings were observed between warfarin use and risk of spine or wrist fracture. CONCLUSIONS: Long-term use of warfarin among older adults with atrial fibrillation is not associated with increased risk of osteoporotic fractures and thus, does not necessitate additional surveillance or prophylaxis.
2031-01-01

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Tan, Boon-Kiang. "Non-invasive determinants of osteoporotic fracture risk." University of Western Australia. Centre for Musculoskeletal Studies, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0125.

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[Truncated abstract] The cost of managing osteoporotic fractures places a significant financial burden on the health-care system. To reduce the fracture burden, early identification of fracture risk is essential to allow early intervention. The limitations associated with dual-energy X-ray absorptiometry (DXA), such as limited sensitivity and specificity, cost, ionising radiation and accessibility, have resulted in the emergence of other technologies for assessing bone fragility. An example is the portable and non-ionising quantitative ultrasound (QUS) technology. The discriminatory power of quantitative ultrasonometry in fracture risk identification, either independently or in combination with other established risk factors, currently remains contentious. It is recommended that fracture risk assessment should not only focus on bone status, but also on the risk of falls. Additionally, it has been noted that disability arising from osteoporotic fractures, even when these fractures are not identified clinically, can translate into psychosocial symptoms and a poorer perception of health-related quality of life (HRQoL). The primary aim of the present study was to investigate if a composite model comprising: calcaneal QUS, falls risk and HRQoL assessments, can identify a group of elderly women at high risk of osteoporotic fracture from those at lower risk. One hundred and four community-dwelling women (mean age 71.3 ±5.8 years) were recruited for this study. These women underwent a series of tests that included: DXA bone mineral density (BMD) evaluation of the proximal femur and lumbar spine (L1 L4); calcaneal QUS measurement; spinal radiography; rasterstereographic back surface curvature (BSC) examination; and performance-based assessment of strength, mobility and balance. The women were classified into a `High Risk’group or a `Low Risk’ group using three separate classification criteria: i) low BMD, based on the World Health Organisation (WHO) recommended T-score of < -2.5, and⁄or a history of fragility fracture (Osteoporotic [OP] group versus Non-Osteoporotic [NOP] group); ii) presence of at least one radiographically identified prevalent vertebral fracture (Vertebral Fracture [VF] group versus Non-Vertebral Fracture [NVF] group); or iii) a history of either forearm or wrist fracture (Forearm/Wrist Fracture [WF] group versus Non-Forearm/Wrist Fracture [NWF] group)

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Ridzwan, Mohamad. "A computational orthopaedic biomechanics study of osteoporotic hip fractures." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47971.

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Low dual energy X-ray absorptiometry (DXA) measured bone mineral density (BMD) is used as an indicator of reduced bone strength and increased risk of fracture. BMD is widely used to identify patients for fracture prevention treatment. However, many fracture patients are not osteoporotic and would not have been identified by BMD screening. Also, BMD screening vastly overpredicts the number of patients who will progress to fracture. In summary, there is a need to improve explanation and prediction of femoral fracture. The overall aim of this thesis was to develop a finite element (FE) methodology that can explain (better than BMD) femoral fractures. An additional aim was to develop a novel experimental methodology, computed tomography (CT)-based digital volume correlation (CT-DVC). This method measures internal strain and fracture and served as validation for the FE methodology. The study included three groups of femur specimens; Group 1: 15 cadavers served as non-fracture controls, Group 2: 14 patients who had suffered a femoral fracture and Group 3: 13 patients scheduled for arthroplasty due to osteoarthritis served as a second non-fracture control group. The correlation of FE-predicted fracture load with in-vitro testing of cadaveric femurs was superior to that of BMD predictions (R2 = 0.77 and R2 = 0.59). Also, the match between CT-based FE models and the experimental observations was reasonably good (73% match) whereas BMD is unable to explain the fracture type. FE-predicted fracture types matched 13 of 14 patient-specific clinical fractures. Including bone quality and load (fall) direction, FE explained many of the clinical fractures that BMD was unable to explain and critical fall directions were identified. FE predicted lower strength of the fracture group which was associated with smaller sizes of anatomical parameters. Also the CT- DVC method demonstrated consistent results and was deemed to have great potential for a wide range of orthopaedic applications.

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Korpelainen, R. (Raija). "Exercise and risk factors of osteoporotic fractures in elderly women." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278054.

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Abstract The aim of this study was to examine lifestyle risk factors for low bone mass, falls and fractures, and to determine the effect of 30-month exercise trial on bone mass, balance, muscle strength and gait in elderly women. Reliability of an inclinometric method for assessing postural sway was evaluated. Data on risk factors, falls and fractures were collected by questionnaires, and calcaneus and radius bone mass were measured from 1,222 women. Lifetime physical activity, low occupational physical activity, type 2 diabetes, hypertension, hormone replacement, thyroid hormone and thiazide use were associated with increased bone mass, while low current physical activity, high coffee intake and late menarche were associated with low bone mass in lean women. Factors associated with fractures were: low lifetime habitual physical activity, diabetes, living alone and calcaneum bone mass. One hundred and sixty women with low femoral neck bone mass were randomly assigned to the exercise group (n = 84) or to the control group (n = 76). The outcomes included radius, proximal femur and calcaneus bone mass, postural sway, muscle strength, gait speed and endurance. Bone mineral density (BMD) at proximal femur decreased in the control group, while no change occurred in the exercise group. Mean trochanter bone mineral content (BMC) decreased more in the control group. The women in the exercise group improved their performance in walking speed and endurance, body sway and leg strength compared to the control group. There were six falls that resulted in fractures in the exercise group and 16 in the control group. The inclinometric method proved to be reliable. In conclusion, lifestyle factors are determinants of bone mass in lean elderly women. Long-term exercise has a site-specific effect on BMC but not on BMD in elderly women. Weight-bearing exercise can modify risk factors for fractures, and may even prevent fall-related fractures in elderly women.

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Hallberg, Inger. "Health-Related Quality of Life in Postmenopausal Women with Osteoporotic Fractures." Doctoral thesis, Linköpings universitet, Omvårdnad, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51524.

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Background: The global burden of osteoporosis includes considerable numbers of fractures, morbidity, mortality and expenses, due mainly to vertebral, hip and forearm fractures. Underdiagnosis and undertreatment are common. Several studies have shown decreased health-related quality of life (HRQOL) after osteoporotic fracture, but there is a lack of data from long-term follow-up studies, particularly regarding vertebral fractures, which are often overlooked despite patients reporting symptoms. Aim: The overall aim of this thesis was to evaluate the usefulness of a recent low-energy fracture as index event in a case-finding strategy for osteoporosis and to describe and analyse long-term HRQOL in postmenopausal women with osteoporotic fracture. The specific aims were to describe bone mineral density and risk factors in women 55-75 years of age with a recent low-energy fracture (I), estimate the impact of osteoporotic fractures on HRQOL in women three months and two years after a forearm, proximal humerus, vertebral or hip fracture (II), investigate the changes and long-term impact of vertebral or hip fracture on HRQOL in women prospectively between two and seven years after the inclusion fracture (III), and describe how HRQOL and daily life had been affected in women with vertebral fracture several years after diagnosis (IV). Design and methods: Data were collected from southern Sweden between 1998 and 2008. A total of 303 women were included in Study I, and this group served as the basis for Studies II (n=303), III (n=67), and IV (n=10). A cross-sectional observational, case-control design (I), and a prospective longitudinal observational design (II-III) were used. In Study IV a qualitative inductive approach with interviews was used and data were analysed using a qualitative conventional content analysis. Results: The type of recent fracture and number of previous fractures are important information for finding the most osteoporotic women in terms of severity (I). Hip and vertebral fractures in particular have a significantly larger impact on HRQOL evaluated using the SF-36 than do humerus and forearm fractures, both during the three months after fracture and two years later, compared between the different fracture groups and the reference population (II). Women who had a vertebral fracture as inclusion fracture had remaining pronounced reduction of HRQOL at seven years. At the mean age of 75.5 years (±4.6 SD), the prevalence of vertebral fracture suggests more negative long-term impact on HRQOL, more severe osteoporosis and a poorer prognosis than a hip fracture does, and this effect may have been underestimated in the past (III). Study IV demonstrates that the women’s HRQOL and daily life have been strongly affected by the long-term impact of the vertebral fracture several years after diagnosis. The women strive to maintain their independence by trying to manage different types of symptoms and consequences in different ways. Conclusions and implications: Type and number of fractures should be taken into account in the case-finding strategy for osteoporosis in postmenopausal women between 55 and 75 years of age. The long-term reduction of HRQOL in postmenopausal women (age span 55-75 yr) with vertebral fracture emerged clearly, compared to women with other types of osteoporotic fractures and references in this thesis. The results ought to be taken into consideration when developing guidelines for more effective fracture prevention and treatment, including non-pharmacological intervention for women with osteoporotic fractures, with highest priority placed on vertebral fractures and multiple fractures, to increase or maintain HRQOL.

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Gao, Xin. "Economic evaluation of three preventive drug therapies for osteoporotic fractures among women at different risk levels." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2045.

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Thesis (Ph. D.)--West Virginia University, 2001.
Title from document title page. Document formatted into pages; contains xi, 211 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 171-186).

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Slavens, Melanie Jean. "Milk Intake in Early and Late Adulthood and Risk of Osteoporotic Hip Fractures in Utah." DigitalCommons@USU, 2006. https://digitalcommons.usu.edu/etd/5532.

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The relationship between milk intake and risk of osteoporotic fractures is uncertain. Associations between milk intake and milk avoidance in relation to osteoporotic hip fracture were examined in the Utah Study of Nutrition and Bone Health (USNBH), a statewide case-control study. Cases were ascertained at Utah hospitals treating 98 percent of hip fractures during 1997-2001 and included 1188 men and women aged 50-89 years. Age- and gender-matched controls were randomly selected from Utah driver's license and Medicare databases (N= 1324). In-person interviews were conducted and participants reported frequency of milk intake per week at age 18 and during pregnancy among women who reported being pregnant. Milk avoidance for a period of more than one year and duration of milk avoidance were also reported. Diet and supplement intake in the one-year period before fracture (cases) or the interview (controls) was assessed using a picture-sort food frequency questionnaire. Milk consumption frequency was categorized into four levels of intake at each life stage. Total calcium intake was categorized into quintiles of distribution of intake. Logistic regression models were used to examine associations between milk intake and milk avoidance and risk of hip fracture while controlling for the potential confounding effects of gender, age, body mass index, alcohol use, smoking, physical activity, estrogen use, and total calorie, protein, calcium, and vitamin D intake. Recent milk intake, milk intake during pregnancy, and milk avoidance duration were not associated with risk of hip fracture. A borderline association was found at age 18 showing a decreased risk of hip fracture among those in the highest quartile (2: 15 cups of milk per week) of milk intake (odds ratio (OR): 0.86, 95 percent confidence interval (Cl): 0.75, 1.00; P = 0.046). Milk avoidance for a year or more was associated with an increased risk of hip fracture compared to those who did not avoid milk (OR: 1.38, 95 percent CI: 1.07, 1.78). A significant interaction was found between milk avoidance and quintile of total calcium intake (P = 0.02). Milk avoidance was associated with a significantly higher risk of hip fracture at the lowest two quintiles of calcium intake (OR: 1.72, 95 percent CI: 1.26, 2.17; P = 0.02 and OR: 1.58, 95 percent CI: 1.01, 2.15; P = 0.01, respectively) but was not associated with elevated risk among those with higher calcium intakes. In conclusion, milk intake during pregnancy for women, and in the year before hip fracture (for cases) or before interview (for controls), was not associated with hip fracture risk. The highest level of milk intake at age 18 was associated with decreased risk of hip fracture. Avoidance of milk for one year or more was associated with hip fracture risk, but only among those with low calcium intake (Q1 and Q2).

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Dodds, R. A. "Structural and metabolic studies on normal and pathological bone." Thesis, Brunel University, 1985. http://bura.brunel.ac.uk/handle/2438/4870.

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Bone is refractory to most conventional biochemical Procedures. However because it is now possible to cut sections (e. g. lopm) of fresh, undemineralized adult bone, this tissue can be analyzed by suitably modified methods of quantitative cytochemistry. A new substrate for assaying hydroxyacyl dehydrogenase activity demonstrated that bone cells may use fatty acids as a major source of energy: detailed analysis of the activities of key enzymes indicated that the paradox of ‘aerobic glycolysis’ of bone could be explained by fatty acid oxidation satisfying the requirements of the Krebs' cycle and directing the conversion of pyruvate to lactate The influence of glucose 6-phosphate dehydrogenase (G6PD) activity in aerobic glycolysis has been considered. The inverse relationships between this activity and that of Na-K-ATPase led to the development of a new method for the latter, based on a new concept in cytochemistry ('hidden-capture' procedure). A major feature of fracture-healing is increased periosteal G6PD activity. The association with the vitamin K cycle has been investigated by feeding rats with dicoumarol which not only inhibited bone-formation but also G6PD activity. The stimulation of this activity in fracture-healing has been linked with ornithine decarboxylase (ODC) activity, for which a new method has been developed. Rats deficient in pyridoxal phosphate (cofactor for ODC) had decreased G6PD responses and also appeared to become osteoporotic. Studies on osteoporotic fractures in the human showed the presence of relatively large apatite crystals close to the fracture-site, and disorganized glycosaminoglycans (demonstrated by the new method of ‘induced birefringence’).

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Bienert, Michaela [Verfasser], Wilhelm [Akademischer Betreuer] Jahnen-Dechent, and Sabine [Akademischer Betreuer] Neuß-Stein. "Biologically active bone replacement materials for osteoporotic fractures / Michaela Bienert ; Wilhelm Jahnen-Dechent, Sabine Neuß-Stein." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1181192919/34.

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Books on the topic "Osteoporotic fractures"

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name, No. Vertebral osteoporotic compression fractures. Philadelphia, PA: Lippincott Williams & Wilkins, 2002.

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Obrant, Karl, ed. Management of Fractures in Severely Osteoporotic Bone. London: Springer London, 2000. http://dx.doi.org/10.1007/978-1-4471-3825-9.

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Razi, Afshin E., and Stuart H. Hershman, eds. Vertebral Compression Fractures in Osteoporotic and Pathologic Bone. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33861-9.

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Ringe, Johann. Osteoporotic fractures in the elderly: Clinical management and prevention. Stuttgart: Georg Thieme Verlag, 1996.

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Wendlova, Jaroslava. Biomechanical variables in assessment of fracture risk. Hauppauge, N.Y: Nova Science, 2011.

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iSpine: Evidence-based interventional spine care. New York: Demos Medical, 2011.

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Genant, Harry K. Vertebral fracture in osteoporosis. Edited by Jergas Michael and Van Kuijk Cornelis. San Francisco, Calif: University of California, San Francisco, 1995.

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Takahashi, Hideaki E., David B. Burr, and Noriaki Yamamoto, eds. Osteoporotic Fracture and Systemic Skeletal Disorders. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5613-2.

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Griffin, Jane. Osteoporosis and the risk of fracture. London: Office of Health Economics, 1990.

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Sinaki, Mehrsheed. Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention. Cham: Springer International Publishing, 2017.

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Book chapters on the topic "Osteoporotic fractures"

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Bartl, Reiner, and Bertha Frisch. "Osteoporotic Fractures." In Osteoporosis, 165–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-79527-8_23.

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Vialle, Luiz R., and Emiliano N. Vialle. "Osteoporotic Fractures." In Essentials of Spine Surgery, 61–68. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80356-8_10.

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Lasanianos, Nick G., George K. Triantafyllopoulos, and Spiros G. Pneumaticos. "Osteoporotic Vertebral Fractures." In Trauma and Orthopaedic Classifications, 251–54. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6572-9_56.

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Tosounidis, Theodoros H., and Michael G. Kontakis. "Osteoporotic ankle fractures." In Surgical and Medical Treatment of Osteoporosis, 261–66. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429161087-27.

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Ong, Terence, and Opinder Sahota. "Osteoporotic thoracolumbar fractures." In Surgical and Medical Treatment of Osteoporosis, 305–14. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429161087-31.

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Telera, Stefano, Laura Raus, Valerio Pipola, Federico De Iure, and Alessandro Gasbarrini. "Osteoporotic Vertebral Fractures." In Vertebral Body Augmentation, Vertebroplasty and Kyphoplasty in Spine Surgery, 133–48. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76555-2_9.

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Gudmundsdottir, Rakel Sif. "The Elderly Osteoporotic Patient." In Distal Radius Fractures, 241–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54604-4_30.

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Saleh, Ahmed, and Michael Collins. "Osteoporotic Vertebral Compression Fractures." In Vertebral Compression Fractures in Osteoporotic and Pathologic Bone, 57–62. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33861-9_6.

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Riancho, José A., and Flor M. Pérez-Campo. "Pharmacogenomics of Osteoporotic Fractures." In Methods in Molecular Biology, 661–70. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0956-8_17.

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Dennison, Elaine, and Cyrus Cooper. "Epidemiology of Osteoporotic Fractures." In Osteoporosis in Clinical Practice, 29–37. London: Springer London, 2004. http://dx.doi.org/10.1007/978-0-85729-402-9_5.

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Conference papers on the topic "Osteoporotic fractures"

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M Benneker, Lorin. "Osteoporotic Spine Fractures." In eccElearning Postgraduate Diploma in Spine Surgery. eccElearning, 2017. http://dx.doi.org/10.28962/01.3.122.

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Kasra, Mehran, Marc D. Grynpas, Rajka Soric, and Sara Arnaud. "A Clinical Evaluation of Vibration Testing in the Assessment of Osteoporosis." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2587.

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Abstract Bone fracture is one of the most common medical problems which reduces the quality of life of individuals. In the United States, osteoporosis alone causes 1.3 million bone fractures a year, with an annual cost of $5.2 billion dollars. Osteoporosis is a disease in which low bone mass and changes in bone quality and architecture increase the risk of fractures. Women are at greater risk of developing osteoporosis than men. Osteoporosis targets both trabecular and cortical bone (Kanis et al., 1994; Kasra and Grynpas, 1994). Therefore, bone density of cortical bone structures such as ulna and mid-radius may be used as a predictor of osteoporotic fractures (Cummings et al., 1993). Bone quality assessment and predicting the risk of bone fracture is very important in prevention of fracture and proper bone treatment. In the NIH Consensus Development Statement (1984), the need for improved measurement techniques is emphasized.

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Natella, LL, N. Bronsard, J. Allia, L. Hekayem, L. Euller-Ziegler, F. De Peretti, and V. Breuil. "FRI0578 Odontoid fractures in the elderly: an unknown osteoporotic fracture?" In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3503.

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Ural, Ani. "Evaluation of Fracture Load in Human Radius via Cohesive Finite Element Modeling." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204316.

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Osteoporotic and age-related fractures are a significant public health problem. One of the most common osteoporotic fracture sites in the aging population is distal radius. There is evidence in the literature that distal radius fractures (Colles’ fracture) are an indicative of increased risk of future spine and hip fractures [1]. Therefore, developing new methods for accurate evaluation of human radius fracture risk is necessary. The previous studies showed that geometrical properties of the radius correlate with its fracture load [2]. However, the combined effect of geometrical and material properties on fracture load has not been studied.

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Stratan, DN, M. Popa, O. Alexa, and L. Stratan. "OP0128 Femoral neck fractures in osteoporotic patients." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.507.

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Chen, Y.-C., and C.-H. Ko. "FRI0526 Anti-osteoporotic therapy decrease cancer risk in patients with osteoporotic vertebral fractures." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3820.

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Salas, Christina, Deana Mercer, Thomas A. DeCoster, and Mahmoud M. Reda Taha. "Experimental and Probabilistic Finite Element Analysis of Distal Femoral Fractures: A Comparison of Locking Plate Versus Intramedullary Nail Fixation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19303.

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In the treatment of unstable, distal, metaphyseal femoral fractures, surgeons have multiple implant options for fixation. Biomechanical studies of intramedullary nailing systems and locking plates have shown that both systems achieve stable fixation of the fracture to allow healing.1–3 These systems are indicated for comminuted fractures, non-unions, and osteoporotic bone where distal femur fractures are associated with a 20% mortality rate in elderly individuals.4 Though capable of achieving stable fixation, both locking and non-locking plates have been associated with periprosthetic fractures in osteoporotic and normal bone.4–6 A recent clinical study reported a 2.6% incidence of periprosthetic fractures at the locking plate end.7

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Hadji, P., B. Schweikert, E. Kloppmann, P. Gille, L. Jöres, E. Toth, L. Möckel, and CC Glüer. "Osteoporotic Fractures and Subsequent Fractures: Imminent Fracture Risk from an Analysis of German Real-World Data." In OSTEOLOGIE 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1680045.

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Ferreri, Suzanne, and Yi-Xian Qin. "Dynamic Mechanical Signals Delivered by Ultrasound Generate Site Specific Mediation of Bone Loss." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206219.

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Osteoporosis is a disease characterized by decreased bone mass and progressive erosion of the microstructure. As a result, bone is at higher risk for developing chronic and traumatic fractures at key skeletal sites. Therapeutic ultrasound may offer a potential non-pharmacologic, site-specific intervention for treatment of osteoporotic bone loss.

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Higgins, Kathryn B., Robert D. Harten, Noshir A. Langrana, and Alberto M. Cuitino. "Biomechanics of Vertebroplasty." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32635.

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Osteoporosis is a skeletal disease characterized by low bone mass and deterioration of bone tissue. It affects 15–20 million women in the United States. Fractures of the vertebrae, wrist and hip are the most common. [1] In the spine, osteoporosis greatly affects the bone mass of the vertebral bodies (VB), the primary structures for transmitting loads in the spine. The VB is comprised of a shell of dense bone surrounding a more porous bony tissue called trabecular bone. Trabecular bone is a lattice-like network of trabeculae in the shape of plates or rods, depending on orientation and one’s age. When the weakened trabecular structure experiences a loss of height, acute back pain, spinal cord compression, and overall loss of mobility can ensue. A single fracture creates a region of high stress in the trabecular network, often leading to more fractures. In almost 20% of the cases one fracture in a VB may result in a secondary fracture within a one year period. [2] Many fractures go unnoticed. The high occurrence, frequent uncertainty of fracture, and gravity of subsequent injury indicate a need to improve the strength of osteoporotic vertebrae before damage can occur. It may be desirable to treat weakened bone prior to fracture. One candidate for prevention that is investigated in this study is vertebroplasty. Currently, the procedure is used to repair fractured VB by injecting acrylic bone cement into the affected level. A parametric finite element (FE) investigation and supporting experimental study was conducted to evaluate the usefulness of vertebroplasty as a preventative treatment.

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Reports on the topic "Osteoporotic fractures"

1

Mao, wei, Ai-guo LI, Fei DONG, Sheng Nan QIN, Pei liang he, guowei huang, and huan chen. Risk factors for secondary fractures to percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0128.

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Li, Tong, Yiran Wang, Qiang Ran, Yang Yu, Leiming Jiang, Yin Shi, Qun Zhou, and Xiaohong Fan. Unilateral curved percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0001.

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Sun, Hai-Bo, Jian-Lin Shan, and Hai Tang. Percutaneous Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures Will Increase the Number of Subsequent Fractures at Adjacent Vertebral Levels: A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0097.

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Dong, Chunke, Di Wu, Yingna Qi, Hongyu Wei, and Chungen Li. Therapeutic efficacy of third-generation percutaneous vertebral augmentation system in osteoporotic vertebral compression fractures: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0015.

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Xiang, Kemeng, Huiming Hou, and Ming Zhou. The efficacy of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates on postmenopausal women with osteoporosis:A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0067.

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Review question / Objective: The aim of this review is to evaluate the effectiveness of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates for postmenopausal osteoporosis. Condition being studied: Postmenopausal osteoporosis (PMOP) is a disorder of bone metabolism caused by estrogen deficiency in women after menopause, which manifests clinically as pain, spinal deformities and even fragility fractures, affecting the quality of life of patients and possibly shortening their life span. Bisphosphonates are commonly used to control and delay the progression of the disease, improve the patient's symptoms and reduce the incidence of fragility fractures. However, single drugs are still lacking in controlling the progression of the disease, and the combination of drugs is the clinical priority.

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Dong, Depeng, Jiajun Huang, Dongxiang Chen, Liang Li, Zhiyong Huang, Dawei Luo, and Wenhui Zhang. Kiva augmentation technique versus balloon kyphoplasty for Osteoporotic vertebral compression fracture. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0068.

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Feng, Ningning, Jianbin Guan, Xing Yu, Wenhao Li, Tao Liu, Guozheng Jiang, Kaitan Yang, Yongdong Yang, and He Zhao. Jintiange Capsule May Have a Positive Effect in OVCF Patients with percutaneous vertebral augmentation: A Meta-Analysis of Randomized Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0038.

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Review question / Objective: We aimed to conduct a meta-analysis of the effects of JTG capsules on patients with OVCF underwent PVA surgery, focusing on clinical outcomes and drug safety. Condition being studied: This meta-analysis aims to systematic evaluation of clinical efficacy and adverse effects of JTG with PVA in the treatment of osteoporotic vertebral compression fracture (OVCF).Our current evidence suggests that JTG capsule may relieve pain in OVCF patients who underwent PVA surgery, improve functional activity, and increase BMD, particularly in patients under the age of 70, as well as increase BGP levels.However, considering the unsatisfactory quality of the included trials, more high-quality trials are needed to prove this issue.

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Wang, Qiang, Changtai Sun, Liang Zhang, Lin Wang, Quan Ji, Nan Min, and Zilong Yin. High- Vs Low-Viscosity Cement Vertebroplasty For Osteoporotic Vertebral Compression Fracture: A Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0110.

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Yokota, Hiroki. Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada613289.

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Yokota, Hiroki. Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada570122.

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