Relevant bibliographies by topics / Osteoporosis

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Academic literature on the topic 'Osteoporosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 July 2024

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Journal articles on the topic "Osteoporosis"

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Baccichetti, A., P. L. Nguyen-Thi, A. Blum, D. Mainard, F. Sirveaux, L. Nace, A. Valance, et al. "SAT0459 EVALUATION OF THE PREVALENCE AND THE MANAGEMENT OF OSTEOPOROTIC FRACTURES IN PATIENTS HOSPITALIZED AT NANCY UNIVERSITY HOSPITAL (FRANCE) IN 2017." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1187.1–1187. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3366.

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Background:Osteoporotic fractures are a major public health concern because of their consequences in morbidity, costs and mortality. In the meantime, historically postfracture osteoporosis medication use rates have been poor.Objectives:The aim is to analyze the management of osteoporosis in patients hospitalized for osteoporotic fractures (OF) at Nancy University Hospital (France) in 2017.Methods:Total number of hospitalized patients and hospital stays were extracted by the Department of Medical Information (DIM) which selected departments with at least forty hospitalizations with Medical Unit Summary related to a diagnosis of fracture or osteoporosis. Hospitalizations not concerned by a recent OF were excluded. Data on fractures, patient characteristics, risk factors for OF and fall, management of osteoporosis, discharge status, stay duration, were studied from patient medical records. Prevalence of OF stays, management of osteoporosis and factors associated with duration of stay were analyzed.Results:Out of a total of 153,840 hospitalizations, 918 hospitalizations (844 patients, mean age 74.5 years ± 13.6, 74.5% women) concern an OF. The prevalence of hospitalizations for OF was 0.6% of total hospitalizations and 17.9% of total hospitalizations for fractures. Among the 844 patients, 85.7% had a severe fracture (vertebral fracture: 56.2%, hip fracture: 24.1%), 16.5% had a non-severe fracture, and 8.5% had a fracture cascade in the year. At discharge from hospital, 11.7% of patients received a specific treatment for osteoporosis. Longer stay duration was associated with age, severe fractures, Groll index and discharge status.Conclusion:Nearly one hospitalized fracture in five is osteoporotic, while only one in ten patients is treated for osteoporosis. Stay duration increased with age and comorbidities. This encourages the development of early prevention, screening and treatment strategies for osteoporosis.References:[1]Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8:136.[2]Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006 Oct 19;17(12):1726–33.[3]Giangregorio L, Papaioannou A, Cranney A, Zytaruk N, Adachi JD. Fragility Fractures and the Osteoporosis Care Gap: An International Phenomenon. Semin Arthritis Rheum. 2006 Apr;35(5):293–305.Disclosure of Interests:None declared
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Pinho, Mara Suzana. "Osteoporos e Osteoporosis." Revista Brasileira de Reumatologia 43, no. 3 (June 2003): 185–88. http://dx.doi.org/10.1590/s0482-50042003000300011.

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Oh, Ho-Seok, Sung-Kyu Kim, and Hyoung-Yeon Seo. "Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017." Healthcare 9, no. 3 (March 14, 2021): 324. http://dx.doi.org/10.3390/healthcare9030324.

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To investigate the incidence and characteristics of osteoporosis and osteoporotic fractures in Korea, we used the Health Insurance Review and Assessment Service (HIRA) database. Patients over 50 years old, who were diagnosed or treated for osteoporosis and osteoporotic fractures in all hospitals and clinics, were analyzed between 1 January 2009 and 31 December 2017 by using the HIRA database that contains prescription data and diagnostic codes. These data were retrospectively analyzed by decade and age-specific and gender-specific incidents in each year. We also evaluated other characteristics of patients including medication state of osteoporosis, primary used medical institution, regional-specific incidence of osteoporosis, and incidence of site-specific osteoporotic fractures. The number of osteoporosis patients over 50 years old, as diagnosed by a doctor, steadily increased from 2009 to 2017. The number of osteoporosis patients was notably greatest in the 60′s and 70′s age groups in every study period. Patients undergoing treatment for osteoporosis increased significantly (96%) from 2009 to 2017. Among the patients diagnosed with osteoporosis, the proportion who experienced osteoporotic fracture increased gradually (60%) from 2009 to 2017. The number of patients with osteoporotic fractures of the spine and hip was highest in the 70 to 90 age range, and the number of patients with osteoporotic fractures in the upper and lower extremities was highest in the 50 to 70 age range. Understanding the trends of osteoporosis in Korea will contribute to manage the increased number of patients with osteoporosis and osteoporotic fractures.
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Kim, Gyu Lee, Yu Hyeon Yi, Hye Rim Hwang, Jinmi Kim, Youngmin Park, Yun Jin Kim, Jeong Gyu Lee, et al. "The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database." Journal of Clinical Medicine 10, no. 9 (May 10, 2021): 2044. http://dx.doi.org/10.3390/jcm10092044.

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Patients with irritable bowel syndrome (IBS) are at increased risk of osteoporosis and osteoporotic fracture. This study investigated whether IBS medication attenuated the rate of osteoporosis and osteoporotic fracture risk. We conducted a retrospective large-scale multicenter study across eight hospital databases encoded in the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM). The primary outcome was the incidence of osteoporosis, whereas secondary outcomes were osteoporotic fractures. After 1:4 matching, 24,723 IBS patients, 78,318 non-IBS patients, 427,640 non-IBS patients with IBS medication, and 827,954 non-IBS patients without IBS medication were selected. The risk of osteoporosis was significantly increased in the IBS group compared to the non-IBS group (hazard ratio (HR) 1.33; confidence interval (CI) 1.17~1.51). Even in patients who were not diagnosed with IBS, the risk of osteoporosis was significantly increased in those with IBS medication compared to those without (HR 1.77, CI 1.62~1.93). The risk of osteoporotic fracture was significantly increased in the IBS medication group (HR 1.69, CI 1.55~1.84). Patients exposed to IBS treatment even without IBS diagnosis were at increased risk of osteoporosis and osteoporotic fracture. Early diagnosis and treatment of osteoporosis should be considered in patients who have received medication for IBS symptoms.
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Fathala, Ahmed L., Sami Alkulaybi, Abdulrahman Khawaji, Abdelghafour Alomari, and Ahmed Almuhaideb. "The association between low bone mineral density and coronary artery calcification in osteoporotic and non-osteoporotic patients in a tertiary center in Saudi Arabia." Annals of Saudi Medicine 41, no. 2 (April 2021): 101–8. http://dx.doi.org/10.5144/0256-4947.2021.101.

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BACKGROUND: Cardiovascular disease (CVD) and osteoporosis are major health-care concerns worldwide. The evidence is contradictory on whether a relationship exists between low bone mineral density (BMD) determined by dual-energy absorptiometry (DXA scan) and coronary artery calcification (CAC) measured by computed tomography. Currently, there are no data on patients from Saudi Arabia. OBJECTIVE: Examine the relationship between CAC and BMD in both genders and study the influence of traditional coronary artery disease (CAD) risk factors and osteoporosis. DESIGN: Retrospective, cross-sectional, analytical. SETTING: Single tertiary care center. PATIENTS AND METHODS: We searched radiology databases for patients who underwent both DXA and CAC score scanning within six months of each other. The inclusion criterion was an absence of any history of CAD. MAIN OUTCOME MEASURE: Association between osteoporosis and CAC. SAMPLE SIZE: 195 (34 osteoporosic, 161 normal BMD or osteopenic) RESULTS: Most of the study population (57.4%) were females. The mean age of all patients was 63.6 (10.1) years. Participants with CAC scores of 0 were significantly younger than those who had CAC scores >0. The presence of diabetes mellitus, hypertension, and hypercholesterolemia was higher in patients with CAC scores >0. CAC score and other CAD risk factors were not significantly different between the osteoporotic and nonosteoporotic groups, except for body mass index. A high CAC score (>100) was present in 28%, 20%, 11%, and 30% of participants with no osteoporosis, osteoporosis of the lumbar spine, osteoporosis of the femoral neck, and participants with osteoporosis of both the lumbar spine and femoral neck, respectively ( P =.762), suggesting there is no association between CAC and the presence of osteoporosis. CONCLUSIONS: Osteoporosis is not associated with higher CAC scores in Saudi Arabia and CAD risk factors are not significantly prevalent in osteoporosis. It appears that CAC and osteoporosis are independent age-related diseases that share common risk factors. LIMITATIONS: Single-center, retrospective. CONFLICT OF INTEREST: None.
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Maasalu, Katre, Ott Laius, Lidiia Zhytnik, Sulev Kõks, Ele Prans, Ene Reimann, and Aare Märtson. "Featured Article: Transcriptional landscape analysis identifies differently expressed genes involved in follicle-stimulating hormone induced postmenopausal osteoporosis." Experimental Biology and Medicine 242, no. 2 (November 20, 2016): 203–13. http://dx.doi.org/10.1177/1535370216679899.

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Osteoporosis is a disorder associated with bone tissue reorganization, bone mass, and mineral density. Osteoporosis can severely affect postmenopausal women, causing bone fragility and osteoporotic fractures. The aim of the current study was to compare blood mRNA profiles of postmenopausal women with and without osteoporosis, with the aim of finding different gene expressions and thus targets for future osteoporosis biomarker studies. Our study consisted of transcriptome analysis of whole blood serum from 12 elderly female osteoporotic patients and 12 non-osteoporotic elderly female controls. The transcriptome analysis was performed with RNA sequencing technology. For data analysis, the edgeR package of R Bioconductor was used. Two hundred and fourteen genes were expressed differently in osteoporotic compared with non-osteoporotic patients. Statistical analysis revealed 20 differently expressed genes with a false discovery rate of less than 1.47 × 10−4 among osteoporotic patients. The expression of 10 genes were up-regulated and 10 down-regulated. Further statistical analysis identified a potential osteoporosis mRNA biomarker pattern consisting of six genes: CACNA1G, ALG13, SBK1, GGT7, MBNL3, and RIOK3. Functional ingenuity pathway analysis identified the strongest candidate genes with regard to potential involvement in a follicle-stimulating hormone activated network of increased osteoclast activity and hypogonadal bone loss. The differentially expressed genes identified in this study may contribute to future research of postmenopausal osteoporosis blood biomarkers.
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Laffaire, M., M. Caroline, E. Allado, E. Bauer, I. Chary Valckenaere, and D. Loeuille. "AB0948 Osteoporotic screening and prevalence of severe osteoporotic fractures in a population of psoriatic arthritis initiating a biologic treatment." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1602.2–1603. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3871.

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BackgroundOsteoporosis is a common complication of Rheumatic diseases. The association between osteoporosis and rheumatoid arthritis is clearly demonstrated while this association is still debated as well as for the screening of osteoporosis by Dual-Energy X-Ray Absorptiometry (DEXA) or to demonstrate an increased risk of fracture on radiography in a population of Psoriatic Arthritis (PsA). The prevalence of fragility fractures reported on medical reports ranged between 12% and 40% in PsA patients. Only a few studies evaluated the prevalence of vertebral fracture (VF) on spine radiographs. To our knowledge no study has evaluated the contribution of radiographic or CT assessment of the spine on the prevalence of fragility fracture reported in medical records.ObjectivesTo determine Psoriatic Arthritis patient’s characteristics screened for osteoporosis by DEXA in a population initiating a biologic treatment (bDMARD) and to estimate the prevalence of severe osteoporotic fractures on medical reports and after imaging modalities scoring (X-ray or CT-scan).MethodsPatients with psoriasis should satisfy the CASPAR or ASAS criteria and have been screened during their follow up for a bDMARD. Osteoporotic screening was defined by a BMD testing (DEXA). Vertebral fractures were scored according to Genant’s method on spine X-ray or sagittal CT-scan images. Clinical and demographic data and the presence of previous severe osteoporotic fracture reported in the medical records were collected.ResultsOn 417 PsA patients screened for bDMARDs during 2008-2019, 89 patients (21.3%) were assessed for osteoporosis by DEXA. Increased age, female sex, menopause, previous severe fracture, disease duration, presence of inflammatory bowel disease, current and previous corticosteroid and bDMARDs uses were significantly associated with osteoporotic screening. On DEXA, 7 patients (7.9%) were classified as osteoporotic. The prevalence of severe osteoporotic fracture was 6.7% in medical reports and increased to 23.6% after scoring spine radiographies or TAP-CT images. In univariate analysis the presence of severe osteoporotic fractures was associated with age (p=0.013), scanographic bone attenuation coefficient (p=0.005) and Lumbar T-score (p=0.039).ConclusionLess than a quarter of PsA patients initiating a bDMARD is screened for osteoporosis. The prevalence of osteoporosis on DEXA and severe osteoporotic fractures on medical records are inferior to 10%. After systematic imaging evaluation, this prevalence increases at 23.6%.References[1]Chandran S, Aldei A, Johnson SR, Cheung AM, Salonen D, Gladman DD. Prevalence and risk factors of low bone mineral density in psoriatic arthritis: A systematic review. Seminars in Arthritis and Rheumatism. oct 2016[2]Riesco M, Manzano F, Font P, García A, Nolla JM. Osteoporosis in psoriatic arthritis: an assessment of densitometry and fragility fractures. Clinical Rheumatology. déc 2013[3]Pedreira PG, Pinheiro MM, Szejnfeld VL. Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis. Arthritis Res Ther. févr 2011[4]Del Puente A, Esposito A, Costa L, Benigno C, Del Puente A, Foglia F, et al. Fragility Fractures in Patients with Psoriatic Arthritis. The Journal of Rheumatology Supplement. 1 nov 2015[5]van der Weijden MAC, van der Horst-Bruinsma IE, van Denderen JC, Dijkmans BAC, Heymans MW, Lems WF. High frequency of vertebral fractures in early spondylarthropathies. Osteoporos Int. juin 2012[6]Pickhardt PJ, Pooler BD, Lauder T, del Rio AM, Bruce RJ, Binkley N. Opportunistic Screening for Osteoporosis Using Abdominal Computed Tomography Scans Obtained for Other Indications. Ann Intern Med. 16 avr 2013[7]Kwok TSH, Sutton M, Yang Ye J, Pereira D, Chandran V, Gladman DD. Prevalence and factors associated with osteoporosis and bone mineral density testing in psoriatic arthritis. Arthritis Care & Research. 16 déc 2020[8]Gulati AM et al. Osteoporosis in psoriatic arthritis: a cross-sectional study of an outpatient clinic population. RMD Open. juin 2018Disclosure of InterestsNone declared
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Marchenkova, L. "POS1469-HPR THE ASSESSMENT OF FRACTURE RISK AND OSTEOPOROSIS RATE AMONG PATIENTS OVER 50 YEARS OLD UNDERGOING MEDICAL REHABILITATION." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1020.2–1020. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4258.

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Background:Taking a course of physical rehabilitation creates the prerequisites for falls and injuries in patients at high risk of fractures. Data on fracture risk and prevalence of osteoporosis in older patients starting medical rehabilitation can change the approach of doctors to the development of rehabilitation programs and the management of such patients.Objectives:To assess the prevalence of osteoporosis, individual risk factors for osteoporosis as well as the proportion of people with high risk of osteoporotic low-energy fractures among patients over 50 years old undergoing treatment according to the “medical rehabilitation” profile.Methods:The study group comprised of 600 patients (426 women and 174 men) aged 50 to 84 years, average age 64.25 ± 10.17 years, undergoing treatment in a rehabilitation department. This was a cross-sectional study in the form of unified questionnaire, including data concerning age, weight, height, BMI, clinical and rehabilitation diagnosis, anamnesis of the main disease, anamnesis vitae, presence of osteoporosis diagnosis in the anamnesis, its treatment, osteoporosis risk factors estimation. An assessment of 10-year probability of osteoporotic fractures was carried out using Russian model of online FRAX® calculator.Results:41.8% patients in the study sample had osteoporosis risk factors, including 31.2% of subjects had 3 risk factors or more. 38.0% patients showed a high fracture risk according to the FRAX calculator. 34.1% had a diagnosis of osteoporosis, and 45.8% already had osteoporotic fractures. Among those who did not undergo densitometry examination, 69.9% had a history of low-traumatic fractures, and only 58.5% of patients with an established diagnosis of osteoporosis and 26.8% of those at high risk of fractures received effective therapy for osteoporosis.Conclusion:Population of patients over 50 years old undergoing rehabilitation is characterized by high frequency of osteoporosis and probability of fractures, and insufficient quality of osteoporosis verification and anti-osteoporotic therapy administration at the same time.Disclosure of Interests:None declared
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Campos, Wladimir Gushiken de, Gonzalo André Montesinos, Rosa Cristina Peinado Agudo, Kaisermann Costa, Luciana Munhoz, and Emiko Saito Arita. "Does type 2 diabetic osteoporotic patients present more periodontal risks than non-osteoporotic patients? An evaluation with mandibular cortical index (Klemetti)." Brazilian Journal of Oral Sciences 17 (December 11, 2018): e181211. http://dx.doi.org/10.20396/bjos.v17i0.8654217.

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Aim: This study aim was to evaluate if patients with type 2 diabetes and osteoporosis have an increased risk of periodontal disease (horizontal and vertical bone loss) when compared to diabetic patients without osteoporosis. Additionally, to assess if patients with diabetes and osteoporosis have a greater risk of reduction of bone mineral density in the mandible, expressed by mandibular cortical index (MCI) when compared to diabetic patients without osteoporosis. Methods: 59 patients (39 diagnosed with type 2 diabetes and osteoporosis; 20 diagnosed with type 2 diabetes and without osteoporosis) were selected. Type 2 diabetes was previously diagnosed by glycated hemoglobin examination and osteoporosis by peripheral dual-energy x-ray absorptiometry. Mandibular cortical index, as well as the presence of vertical and horizontal bone loss was verified on panoramic radiographs. Adjusted odds ratio analyses were performed on presence of periodontal disease and MCI considering the effect of osteoporosis. Results: Absence of statistical significance between variables was found. Conclusions: There is no difference between the risk of periodontal disease or low MCI among osteoporotic and non-osteoporotic type 2 diabetic patients.
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Nawrat-Szołtysik, Agnieszka, Zuzanna Miodońska, Ryszard Zarzeczny, Izabela Zając-Gawlak, Józef Opara, Alicja Grzesińska, Beata Matyja, and Anna Polak. "Osteoporosis in Polish Older Women: Risk Factors and Osteoporotic Fractures: A Cross–Sectional Study." International Journal of Environmental Research and Public Health 17, no. 10 (May 25, 2020): 3725. http://dx.doi.org/10.3390/ijerph17103725.

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Background: Osteoporosis is a skeletal disease. It is still not known which of the risk factors have the greatest impact on osteoporosis development. The study aimed to determine how the selected osteoporosis risk factors contribute to the development of the disease and to assess the risk of osteoporotic fractures in older women. Methods: A cohort of 99 older females was divided into two groups (with and without osteoporosis). The risk of osteoporosis was determined using assessment forms and bone densitometry data subjected to logistic regression. The risk of osteoporotic fractures was assessed by the FRAX tool (FRAX, Center for Metabolic Bone Diseases, University of Sheffield, UK). Results: The logistic regression analysis showed that the highest risk of developing osteoporosis associated with lifestyle, mainly cigarette smoking (odds ratio: OR = 2.12), past gynecological operations (OR = 1.46), corticosteroid therapies (OR = 1.38). More than half of participants were at a medium risk of femoral neck fractures (over 90% in the osteoporotic group). Conclusion: Most of the Polish women living in care facilities are at medium risk of low-energy fractures. Smoking appeared to have the strongest effect on osteoporosis among analyzed risk factors. The results may contribute to the creation of more appropriate prevention strategies.
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Dissertations / Theses on the topic "Osteoporosis"

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Kaptoge, Stephen Kipkemoi. "Epidemiology of risk factors for osteoporosis and osteoporotic fractures." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615203.

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Wilson, Aubrie. "Osteoporosis." Online version, 2009. http://www.uwstout.edu/lib/thesis/2009/2009wilsona.pdf.

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Misner, Scottie, and Vanessa A. Farrell. "Osteoporosis." College of Agriculture, University of Arizona (Tucson, AZ), 2017. http://hdl.handle.net/10150/625576.

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4 p. / Originally published: 2000.
Osteoporosis means “porous bones.” It is a condition where the skeleton becomes fragile and results in broken bones under normal use. Osteoporosis is a “silent” condition that happens slowly over years. The rate of bone loss (“resorption”) exceeds the rate of new bone formation (“acretion”). Many times neither a person nor a doctor is aware of weakened bones until one breaks unexpectedly. Originally published: 2000
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Misner, Scottie. "Osteoporosis." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2011. http://hdl.handle.net/10150/146661.

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4 pp.
Originally published: 2000
Osteoporosis means "porous bones." it is a condition where the skeleton becomes fragile and results in broken bones under normal use. Osteoporosis is a "silent" condition that happens slowly over years. This publication discusses the symptoms and the risk factors of osteoporosis, as well as how to prevent it.
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Braz, Manuela Giuliani Marcondes Rocha. "Sequenciamento paralelo em larga escala de genes candidatos para fragilidade óssea em indivíduos com osteoporose grave, familiar ou idiopática." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-22102018-123623/.

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A osteoporose é uma doença de alta prevalência na população geral, e a ocorrência de fraturas se associa a grande morbi-mortalidade e impacto econômico. Na maioria dos indivíduos afetados, a osteoporose tem etiologia multifatorial, com herdabilidade estimada entre 50 e 85%, atribuível a um conjunto de variantes genéticas de pequeno efeito individual. Raramente, há casos de osteoporose associada a síndromes monogênicas, decorrentes de defeitos genéticos de grande impacto. Postula-se que indivíduos com quadros extremos de osteoporose não sindrômica possam ter causa genética mono- ou oligogênica, atribuível a variantes de impacto intermediário sobre o fenótipo, ainda pouco reconhecidas. Nos últimos anos, o avanço das tecnologias de sequenciamento permitiu o reconhecimento de novos genes associados à fragilidade óssea e atualmente possibilita a análise simultânea de múltiplos genes. Neste contexto, os objetivos deste projeto de pesquisa foram: 1) buscar genes candidatos para fragilidade óssea previamente associados a doenças Mendelianas com alto impacto na resistência óssea, fenótipos extremos de osteoporose e estudos de associação genética em escala genômica (GWAS) para osteoporose; e 2) pesquisar a presença de variantes alélicas patogênicas nestes genes candidatos em indivíduos com osteoporose grave, familiar ou idiopática. A partir de revisão sistemática, 128 genes candidatos foram selecionados para compor um painel de sequenciamento paralelo em larga escala. O sequenciamento incluiu todos os éxons e 25 pares de bases das junções íntron-éxon. Foram consideradas variantes genéticas de interesse aquelas raras (frequência alélica < 1%) e com predição de alto impacto sobre a proteína codificada. Trinta e sete indivíduos (7 famílias e 21 casos isolados) foram selecionados seguindo critérios clínicos, laboratoriais e densitométricos restritivos, excluindo-se pacientes com causas secundárias de osteoporose. A coorte foi composta por homens em 54%, a mediana de idade ao diagnóstico foi 44 anos e 86% tinham histórico de fratura. Dentre os 28 casos índices, foram identificadas 33 variantes de interesse. Após análise de segregação familiar, foi possível excluir patogenicidade de cinco destas variantes, restando 28 variantes potencialmente patogênicas, presentes em 71% da coorte. Todas as variantes foram encontradas em heterozigose, sendo 26 variantes de ponto não-sinônimas, uma deleção de 9 pares de bases, e uma grande deleção envolvendo o único éxon codificador do gene candidato GPR68. Foi encontrada uma associação de variantes em genes diferentes em 21% da coorte, incluindo uma mulher jovem com osteoporose grave e variantes em WNT1, PLS3 e NOTCH2. A análise de segregação familiar neste caso sugeriu um efeito patogênico aditivo das variantes. Vinte e cinco porcento das variantes potencialmente patogênicas foram identificadas em genes candidatos bem estabelecidos (WNT1, PLS3, COL1A1, COL1A2), e 57% se localizam em novos genes candidatos identificados inicialmente por GWAS, como NBR1 e GPR68, também associados à alteração da remodelação óssea em modelos animais. Os resultados deste trabalho dão relevância a novos genes na fisiologia da resistência óssea e indicam um papel proeminente de interações digênicas/oligogênicas em casos de osteoporose grave, familiar ou idiopática. O reconhecimento de novas vias associadas à fragilidade óssea pode levar ao desenvolvimento de novos tratamentos, e a identificação de variantes patogênicas associadas à osteoporose pode, futuramente, permitir um manejo clínico personalizado de pacientes e seus familiares
Osteoporosis is a highly prevalent disorder resulting in fragility fractures and incurring in great morbi-mortality and economic burden. In most cases, osteoporosis has a multifactorial etiology, with an estimated heritability of 50-85% attributable to a combination of several low-impact genetic variants. Rarely, cases of syndromic osteoporosis due to high-impact genetic defects are seen. It is therefore hypothesized that severe/idiopathic cases of otherwise inconspicuous osteoporosis may have a monoor oligogenic etiology due to genetic variants with an intermediate effect. During the past years, advances in molecular sequencing have revealed novel candidate genes for bone fragility, and have enabled simultaneous sequencing of multiple genes. In this context, the objectives of this research project were: 1) to identify candidate genes for bone fragility, as previously reported in association to Mendelian disorders with high impact on bone resistance, idiopathic or familial osteoporosis, and genome-wide association studies (GWAS) for bone mineral density and fragility fractures; and 2) to perform molecular analysis of these candidate genes in patients with severe, familial or idiopathic osteoporosis. Through a systematic review, 128 candidate genes were identified and included in a panel for massively parallel sequencing. Coding regions and 25-bp boundaries were captured and sequenced. Rare variants (allele frequency < 1%), with a predicted high impact on protein function were initially selected as variants of interest. Thirty-seven subjects (21 sporadic cases and 7 families) were included according to stringent criteria based on clinical and densitometric evaluation, excluding individuals with secondary osteoporosis. Males represented 54% of the cohort, median age at diagnosis was 44 years, and 84% of subjects had a history of fractures. Thirtythree variants of interest were identified initially. After familial segregation analysis, 5 variants were considered as benign in regard to bone fragility, resulting in 28 potentially pathogenic variants, all heterozygous, present in 71% of the cohort. Of these variants, 26 were nonsynonymous, there was one 9-bp deletion and one large deletion involving the only coding exon of candidate gene GPR68. An association of two or more variants in different genes was present in 21% of the cohort, including a young woman with severe osteoporosis and variants in WNT1, PLS3 and NOTCH2. Familial segregation in this case suggested an additive pathogenic effect of these variants. Twenty-five percent of potentially pathogenic variants were identified in well-established candidate genes (WNT1, PLS3, COL1A1, COL1A2), and 57% located to novel candidate genes initially identified by GWAS, such as NBR1 and GPR68, which have been previously associated to changes in bone remodeling in mouse models. These results support the involvement of GWAS genes in the pathophysyiology of osteoporosis, and indicate a prominent role for digenic/oligogenic interactions in cases of severe, familial or idiopathic osteoporosis. Recognition of new molecular pathways in the determination of bone fragility may lead to the development of new drugs, and the identification of pathogenic variants associated to osteoporosis may allow individualized clinical management of patients and their relatives
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Clarke, Michelle Mary. "The role of B-vitamin status, homocysteine and the MTHFR 677C-T polymorphism in bone health." Thesis, Ulster University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669658.

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Osteoporosis is a widespread problem and a major public health challenge, with one in two women and one in five men over the age of 50 years expected to experience an osteoporotic fracture. Various factors contribute to an increased risk of disease including female gender, Caucasian ethnicity, age, physical inactivity, inadequate status of calcium and vitamin D, excessive alcohol intake and smoking. In recent years convincing evidence has emerged linking low B-vitamins, the related metabolite homocysteine (Hcy), and a common polymorphism in folate metabolism (the MTHFR 677C~T polymorphism) with low bone mineral density (BMD) and an increased fracture risk. Patients with coeliac disease (CD), a common autoimmune inflammatory condition characterised by intestinal damage due to gluten consumption, are at increased risk both of osteoporosis and inadequate B-vitamin status. The aim of this thesis was to investigate the role of the B-vitamins, Hcy and the MTHFR 677C~T polymorphism in bone health and disease, including an evaluation of the potential protective role of Bvitamin supplementation in the maintenance of BMD in CD patients. The findings within this thesis provide evidence to supplier an association between bone health and biomarkers of B-vitamin status, particularly vitamin B 12 and vitamin B6, and Hcy (women only). Among those with the variant MTHFR 677TT genotype, a low status of riboflavin (women only), and folate, were associated with a 1.8-2.1 times increased risk of osteoporosis. Preliminary findings from the on-going randomised controlled trial (RCT) suggest a beneficial effect of combined folic acid (400 Ilg/d) and vitamin B 12 (10 Ilg/d) supplementation for a 2 year period on BMD, particularly at the spine in male CD patients, but no firm conclusions can be drawn until completion of the trial. In conclusion, the achievement of optimal B-vitamin status may be important for bone health in normal ageing and within CD patients.
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Pereira, Erika Cristina Sbrisse. "Estudo longitudinal dos efeitos da deficiência estrogênica no fêmur de ratas /." São José dos Campos : [s.n.], 2011. http://hdl.handle.net/11449/95875.

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Resumo: É cada vez maior a parcela de pessoas idosas na população brasileira e com este fenômeno o número de pessoas afetadas por patologias crônico-degenerativas. Dentre estas uma doença que merece destaque é a osteoporose, uma vez que vem se tornando um problema de saúde pública. Um dos principais fatores de risco para osteoporose é a deficiência estrogênica, sendo assim este estudo objetivou avaliar o efeito da deficiência estrogênica no tecido ósseo durante um período de 360 dias através de análise radiográfica e biomecânica. Para tanto 80 ratas, com 3 meses de idade e peso de aproximadamente 250g, foram divididas em 10 grupos experimentais (n=8) de acordo com o tempo de sacrifício e cirurgia a que foram submetidas (ovariectomia e cirurgia sham). As ratas pertencentes aos grupos OVZ e SHAM tiveram sua ração controlada (30g por animal). Após o período determinado (30, 60, 90, 180 e 360 dias das cirurgias) as ratas foram pesadas, anestesiadas e sacrificadas e seus fêmures retirados para análise. Os dados obtidos foram submetidos ao teste estatístico ANOVA e Tukey, com nível de significância de 5%. De acordo com os resultados obtidos observou-se que nos períodos de 30, 60 e 90 dias os efeitos da deficiência estrogênica sobre o tecido ósseo foram significativos
Abstract: The Brazilian population has undergone a process of aging, and this phenomenon with the number of people affected by chronic diseases is increasing. Among these a disease that deserves mention is osteoporosis, since it has become a public health problem. One of the main risk factors for osteoporosis is estrogen deficiency, so to better understand how estrogen deficiency affects the bone tissue present study aimed to evaluate the effect of estrogen deficiency on bone tissue over a period of 360 days by radiographic and biomechanics analysis. For this purpose 80 rats, 3 months old and weighing about 250g were divided into 10 groups (n = 8) according to the time of sacrifice and who underwent surgery (ovariectomy and sham surgery). The rats belonging to groups OVZ and SHAM had controlled his diet (30g per animal). After the specified period (30, 60, 90, 180 and 360 days of surgery) the rats were weighed, anesthetized and sacrificed, and their femurs were removed for analysis. Data were submitted to ANOVA and Tukey tests with significance level of 5%. According to the results obtained showed that in periods of 30, 60 and 90 days the effects of estrogen deficiency on bone tissue were significant
Orientador: Rosilene Fernandes da Rocha
Coorientador: Luana Marotta Reis de Vasconcellos
Banca: Juliana Madureira de Souza Lima Alonso
Banca: Mari Eli Leonelli de Moraes
Mestre
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Vanhook, Patricia M., Lynne M. Dunphy, T. South, L. Plank, and C. Luskin. "Osteoarthritis and Osteoporosis." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7411.

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Book Summary: Serves the needs of advanced practice nurses because it’s written by nurse practitioners for nurse practitioners, in collaboration with a physician. Organizes content around the Circle of Caring framework for nursing-based knowledge and holistic care. Explores complementary and alternative treatments for each disorder. Covers the broadest range of human disease and disorders using a systems-based approach, presenting both common complaints and common problems to help students narrow down the possible differentials to the most likely diagnosis. Considers interactions of pharmaceuticals with alternative medications and nutraceuticals. Features coverage of pathophysiology and diagnostic reasoning as well as up-to-date guidance on laboratory and diagnostic tests. Emphasizes evidence-based practice with information on evidence levels and more references to primary studies. Integrates discussions of health policy and primary care throughout the text.
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Freitas, Deborah Queiroz de 1977. "Avaliação do efeito radioprotetor do selenito de sodio na reparação de tibias de ratas ovariectomizadas." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290143.

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Orientador: Solange Maria de Almeida
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: A osteoporose e a irradiação são fatores que interferem no processo de reparação óssea e podem ocorrer simultaneamente, especialmente em mulheres idosas. Atualmente, várias substâncias, conhecidas como radioprotetores, têm sido estudadas, pois minimizam os efeitos deletérios da radiação; dentre eles, pode-se citar o selênio. O objetivo desse trabalho foi avaliar o efeito radioprotetor do selenito de sódio no processo de reparo ósseo em ratas ovariectomizadas submetidas à irradiação. Para isso, oitenta ratas foram submetidas à ovariectomia e divididas em quatro grupos: ovariectomizado, ovariectomizado/selênio, ovariectomizado/irradiado e ovariectomizado/selênio/irradiado. Quarenta dias após, um defeito ósseo foi confeccionado nas tíbias dos animais. Dois dias após essa cirurgia, os animais dos grupos ovariectomizado/selênio eovariectomizado/selênio/irradiado receberam 0,8 mg Se/Kg de peso corpóreo. No dia seguinte, apenas os animais pertencentes aos grupos ovariectomizado/irradiado e ovariectomizado/selênio/irradiado receberam 10 Gy de radiação X na região dos membros inferiores. Os animais foram sacrificados 7, 14, 21 e 28 dias após a cirurgia. O processo de reparação óssea foi avaliado por análise morfológica, utilizando-se a coloração pelo Tricrômico de Masson, e por análise do número de trabéculas ósseas e da birrefrigência (coloração pelo Picrosírius). Pela análise morfológica, foi possível observar um atraso no processo de reparo ósseo nos animais do grupo ovariectomizado/irradiado e similaridade entre os grupos ovariectomizado, ovariectomizado/selênio e ovariectomizado/selênio/irradiado, o que demonstrou o efeito radioprotetor do selênio sem toxicidade
Abstract: Osteoporosis and ionizing radiation affect the bone healing and people can suffer both conditions, especially older women. At the moment, antioxidant radioprotectors have been evaluated, such selenium compounds. This study aimed at evaluating the selenium protection in the bone repair process in ovariectomized rats submitted to an irradiation procedure. For this purpose, eighty ovariectomized female Wistar rats were randomly divided in four experimental groups: ovariectomized, ovariectomized/selenium, ovariectomizedlirradiated and ovariectomized/selenium/irradiated. Abone defect was made on all animals' tibias forty days after ovariectomy. Two days after surgery, only ovariectomized/selenium and ovariectomized/seleniumlirradiated rats received 0.8 mg Se/Kg. Three days after surgery, only ovariectomized irradiated and ovariectomized/selenium/irradiated rats received 10 Gy of X rays on the lower limbs region. The animals were sacrificed 7, 14, 21 and 28 days after surgery in order to assess the repair process, which was evaluated by morphologic analysis in Masson Tricromic. lt was also evaluated by analysis of trabecular bone number in Masson Tricromic and birefringence analysis in Picrosirius. It was possible to observe a delay in the bone repair process in the irradiated/ovariectomized group and similarity between ovariectomized, ovariectomized/selenium and ovariectomized/selenium/irradiated, which proved the selenium radioprotection without its toxicity
Doutorado
Radiologia Odontologica
Doutor em Radiologia Odontológica
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Ferreira, Gabriel Ramalho [UNESP]. "Avaliação do reparo ósseo na interface osso/implante em ratas com osteoporose induzida tratadas com raloxifeno ou alendronato: análise histométrica, imunoistoquímica, por epifluorescência e biomecânica." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/127657.

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O objetivo deste estudo foi avaliar o reparo ósseo na interface osso/implante em ratas com osteoporose induzida. As ratas submetidas à ovariectomia bilateral foram alimentadas com uma dieta pobre em cálcio. Dois grupos receberam tratamento medicamentoso (raloxifeno [OVX RAL] ou alendronato [OVX ALE]) e outro grupo não recebeu nenhuma medicação (OVX ST). O grupo controle foi submetido à cirurgia fictícia e foi alimentado com uma dieta normal (SHAM DN). Cada animal recebeu um implante em cada tíbia. Os animais foram eutanasiados após 14 ou 42 dias. Foram realizadas as análises biomecânica (torque reverso), extensão linear de contato osso/implante (ELCOI) e dinâmica óssea periimplantar pela proporção dos fluorocromos calceína/alizarina, aplicando-se a análise de variância ANOVA e o pós-teste de Tukey (p<0,05). A imunoistoquímica marcou a precipitação de osteoprotegerina (OPG), RANKL, TRAP e osteocalcina (OC). O medicamento RAL melhorou o reparo ósseo periimplantar, em que o grupo ALE foi semelhante ao grupo OVX ST. Não houve diferenças estatisticamente significativas no torque reverso (p = 0,861), na precipitação dos fluorocromos (calceína/alizarina) e na ELCOI entre os grupos OVX RAL e grupo controle - SHAM DN (p > 0,05). As imunomarcações de OPG e RANKL foram similares para os grupos RAL e SHAM; houve moderada expressão de OC aos 14 dias. A TRAP foi marcada intensamente aos 42 dias para o grupo OVX. Portanto, o raloxifeno melhorou o reparo ósseo periimplantar de ratas osteoporóticas, sugerindo a sua indicação no tratamento da osteoporose.
The aim of this study was to evaluate the bone healing in bone/implant interface in rats with induced osteoporosis. The rats underwent bilateral ovariectomy were fed a diet low in calcium. Two groups received drug treatment (raloxifene [OVX RAL] or alendronate [OVX ALE]) and the other group received no medication (OVX NT). The control group underwent sham surgery and was fed a normal diet (SHAM ND). Each animal received an implant on the tibia. The animals were euthanized after 14 or 42 days. The biomechanical analysis (reverse torque), linear extension contact bone / implant (BIC) and bone dynamics periimplantar by the proportion of fluorochrome calcein/alizarin, applying the ANOVA and Tukey's post-test (p<0.05). Immunohistochemistry marked precipitation of osteoprotegerin (OPG), RANKL, TRAP and osteocalcin (OC). The RAL improved drug peri-implant bone repair, wherein the ALE OVX group was similar to the ST group. There were no statistically significant differences in reverse torque (p = 0.861), precipitation of fluorochromes (calcein/alizarin) and BIC between OVX RAL and control groups - SHAM ND (p> 0.05). The immunostaining of OPG and RANKL were similar to RAL and SHAM groups; there was moderate OC expression at 14 days. TRAP was marked intensely at 42 days for the OVX group. Therefore, raloxifene improved peri-implant bone repair of osteoporotic rats, suggesting its indication in the treatment of osteoporosis.
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Books on the topic "Osteoporosis"

1

Orwoll, Eric S., and Michael Bliziotes. Osteoporosis. New Jersey: Humana Press, 2002. http://dx.doi.org/10.1385/1592592783.

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Cusano, Natalie E., ed. Osteoporosis. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-83951-2.

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Bartl, Reiner, and Bertha Frisch. Osteoporosis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-662-09163-0.

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Adler, Robert A., ed. Osteoporosis. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-59745-459-9.

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Stovall, Dale W., ed. Osteoporosis. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118316290.

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Westendorf, Jennifer J., ed. Osteoporosis. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-104-8.

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Leder, Benjamin Z., and Marc N. Wein, eds. Osteoporosis. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-69287-6.

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Rosen, Clifford J., ed. Osteoporosis. Totowa, NJ: Humana Press, 1996. http://dx.doi.org/10.1007/978-1-4612-0221-9.

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Bartl, Reiner, and Bertha Frisch. Osteoporosis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-79527-8.

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Francis, R. M., and W. Carson Dick, eds. Osteoporosis. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-010-9580-8.

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Book chapters on the topic "Osteoporosis"

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da Silva, José António Pereira, and Anthony D. Woolf. "Osteoporotic Syndrome Osteoporosis." In Rheumatology in Practice, 261–69. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-581-9_26.

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Blain, Hubert, Tahir Masud, Finbarr C. Martin, and Stefania Maggi. "Osteoporosis." In Practical Issues in Geriatrics, 209–16. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-61997-2_22.

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Karnes, Jonathan M., and Colleen Watkins. "Osteoporosis." In Orthopedic Surgery Clerkship, 739–41. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52567-9_152.

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Yuksel, Nese, and Theresa L. Charrois. "Osteoporosis." In Patient Assessment in Clinical Pharmacy, 235–43. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11775-7_18.

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Barry, Maurice. "Osteoporosis." In Clinical Practice in Rheumatology, 95–97. London: Springer London, 2003. http://dx.doi.org/10.1007/978-0-85729-430-2_19.

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Pignolo, Robert J. "Osteoporosis." In Classic Papers in Geriatric Medicine with Current Commentaries, 95–104. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-428-5_10.

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Veloski, Colleen. "Osteoporosis." In Women’s Health in Clinical Practice, 47–69. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-469-8_4.

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Miller, Paul D., and Socrates E. Papapoulos. "Osteoporosis." In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 343–44. Ames, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118453926.part5.

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Baum, Thomas, Dimitrios C. Karampinos, Stefan Ruschke, Hans Liebl, Peter B. Noël, and Jan S. Bauer. "Osteoporosis." In Spinal Imaging and Image Analysis, 67–93. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-12508-4_3.

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Annamalai, Aniyizhai. "Osteoporosis." In Medical Management of Psychotropic Side Effects, 289–90. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-51026-2_47.

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Conference papers on the topic "Osteoporosis"

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Paoletti, Nicola, Pietro Liò, Emanuela Merelli, and Marco Viceconti. "Osteoporosis." In the 9th International Conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2037509.2037536.

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Kasra, Mehran, Marc D. Grynpas, Rajka Soric, and Sara Arnaud. "A Clinical Evaluation of Vibration Testing in the Assessment of Osteoporosis." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2587.

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Abstract Bone fracture is one of the most common medical problems which reduces the quality of life of individuals. In the United States, osteoporosis alone causes 1.3 million bone fractures a year, with an annual cost of $5.2 billion dollars. Osteoporosis is a disease in which low bone mass and changes in bone quality and architecture increase the risk of fractures. Women are at greater risk of developing osteoporosis than men. Osteoporosis targets both trabecular and cortical bone (Kanis et al., 1994; Kasra and Grynpas, 1994). Therefore, bone density of cortical bone structures such as ulna and mid-radius may be used as a predictor of osteoporotic fractures (Cummings et al., 1993). Bone quality assessment and predicting the risk of bone fracture is very important in prevention of fracture and proper bone treatment. In the NIH Consensus Development Statement (1984), the need for improved measurement techniques is emphasized.
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de Oliveira, Juliana Silva, and Alexandre dos Santos Gomes. "World of work for graduates of professional education in radiology: Distribution of bone densitometry equipment in the state of Rio de Janeiro." In VI Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvimulti2024-068.

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Bone densitometry (BD) is essential in medicine to assess bone mineral density (BMD) and diagnose osteoporosis, being non-invasive and crucial in the prevention of osteoporotic fractures. Osteoporosis, characterized by reduced BMD, significantly increases the risk of fractures. Early detection through BD is essential to initiate appropriate treatments and monitor their effectiveness, preventing the progression of the disease. DATASUS uses the National Registry of Health Establishments (CNES) to operationalize data, including BD equipment, facilitating the management and monitoring of these resources.
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Kiapour, A., K. Sairyo, T. Terai, V. K. Goel, and N. A. Ebraheim. "Bilateral Laminar Hook Placements Reduces Pedicle Screw Pull Outs in Long Pedicle Screw Fixation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19357.

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The pedicle screw (PS) system has been widely used for the spinal reconstruction. Even for the osteoporotic spine, PS system has been the first choice for the instrumentation. However, the usage of PS in the porotic spine seems to be challenging. When the PS is inserted in the osteoporotic vertebrae, the PS is sometimes loosened; eventually, it shows back out, because the PS cannot hold bones with osteoporosis efficiently [1,2].
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Salas, Christina, Meir Marmor, Thomas Chu, Paul Hansma, Amir Matityahu, and Jenni M. Buckley. "Assessment of Local Bone Quality of the Distal Radius Using a Novel Hard Tissue Diagnostic Instrument." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206823.

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Senile osteoporosis has been defined as a skeletal disorder characterized by a deterioration of bone matrix with an increase in susceptibility to fracture with increasing age (1). Studies have shown that over 25 million Americans are currently afflicted with osteoporosis and/or osteopoenia, with this number doubling by 2020. (2) (3) With the propensity for fracture being large in older osteoporotic patients, quantification of bone mineral density (BMD) is essential for proper implant selection in the event of a fracture. Dual energy x-ray absorptiometry (DEXA) is the clinical gold standard for BMD assessment; however, the hardware associated with this technique is neither portable nor appropriate for intraoperative use, and both of these qualities are occasionally necessary clinically.
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Ferreri, Suzanne, and Yi-Xian Qin. "Dynamic Mechanical Signals Delivered by Ultrasound Generate Site Specific Mediation of Bone Loss." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206219.

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Osteoporosis is a disease characterized by decreased bone mass and progressive erosion of the microstructure. As a result, bone is at higher risk for developing chronic and traumatic fractures at key skeletal sites. Therapeutic ultrasound may offer a potential non-pharmacologic, site-specific intervention for treatment of osteoporotic bone loss.
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Dai, Chao. "Molecular Mechanisms of Osteoporosis: A Road Map for Osteoporosis Therapeutics." In International Conference on Health Big Data and Intelligent Healthcare. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0011372900003438.

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Buckenmeyer, Laura E., Kristophe J. Karami, Ata M. Kiapour, Vijay K. Goel, Constantine K. Demetropoulos, and Teck M. Soo. "Biomechanical Effects of Lumbar Pedicle Screw Insertion Depth on Screw Loosening and Fulcrum Location." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14324.

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Osteoporosis is a critical challenge in orthopedic surgery. Osteoporotic patients have an increased risk of loosening and failure of implant constructs due to a weaker bone-implant interface than with healthy bone. Pullout strength of pedicle screws is enhanced by increased screw insertion depth. However, more knowledge is needed to define optimal pedicle screw insertion depth in relation to screw-bone interface biomechanics and the resulting loosening risk. This study evaluates the effects of screw length on loosening risk in the osteoporotic lumbar spine.
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Abousleiman, Younane N., Son K. Hoang, and Minh H. Tran. "Inclined Direct Shear Testing Device: A New Tool for Bone Mechanics and Osteoporosis Research." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19156.

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Shear properties and strength are crucial for osteoporotic hip and wrist fracture risk assessment. This paper presents the design of a newly developed testing device for bone mechanical properties under circulation of different fluids. The device will ultimately be used to actively modify bone mineral content and porosity to simulate different stages of osteoporosis and directly measure the corresponding changes in mechanical properties. Preliminary results on intact bovine cancellous bones without fluid circulation showed excellent agreement with published literature data.
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Dewi, Patria Sari. "Factors Associated with Osteoporosis." In The 5th Intenational Conference on Public Health 2019. Masters Program in Public Health, Universitas Sebelas Maret, 2019. http://dx.doi.org/10.26911/theicph.2019.01.55.

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Reports on the topic "Osteoporosis"

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su, hui, haipeng xue, ruochong wang, guoqing tan, binghan yan, and zhanwang xu. The efficacy and safety of Tanghuang Jiangu capsule in the treatment osteoporosis: A meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0031.

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Review question / Objective: In order to more systematically and accurately evaluate the clinical efficacy and safety of Tenghuang Jiangu capsule in the treatment of osteoporosis, we used Meta-analysis to provide more reliable evidence-based medical evidence for the treatment of osteoporosis with traditional Chinese medicine. Condition being studied: At present, Tenghuang Jiangu capsule is widely used in clinical practice to treat spinal diseases and improve osteoporosis.Therefore, in order to more systematically and accurately evaluate the clinical efficacy and safety of Tenghuang Jiangu capsule in the treatment of osteoporosis, we used Meta-analysis to provide more reliable evidence-based medical evidence for the treatment of osteoporosis with traditional Chinese medicine.
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2

Bidwell, Joseph. Maximizing PTH Anabolic Osteoporosis Therapy. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada610951.

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Stern, Paula H. Mechanism of Thyroid Hormone-Induced Osteoporosis. Fort Belvoir, VA: Defense Technical Information Center, October 1998. http://dx.doi.org/10.21236/ada368354.

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Stern, Paula H. Mechanism of Thyroid Hormone-Induced Osteoporosis. Fort Belvoir, VA: Defense Technical Information Center, October 1997. http://dx.doi.org/10.21236/ada340690.

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Stern, Paula H. Mechanism of Thyroid Hormone-Induced Osteoporosis. Fort Belvoir, VA: Defense Technical Information Center, October 1999. http://dx.doi.org/10.21236/ada391556.

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Sarafrazi, Neda. Osteoporosis or Low Bone Mass in Older Adults: United States, 2017-2018. National Center for Health Statistics, March 2021. http://dx.doi.org/10.15620/cdc:103477.

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7

Lanske, Beate. Role of Klotho in Osteoporosis and Renal Osteodystrophy. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada613419.

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8

Kelley, George A. Exercise and Osteoporosis: A Dose-Response Meta-Analysis. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada580198.

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9

Polyakova, Yu V., L. E. Sivordova, E. A. Guryanova, B. V. Zavodovsky, and E. N. Shamitova. Is male osteoporosis a medical or social problem? Academy of Natural Knowledge, 2019. http://dx.doi.org/10.18411/2070-7428-2019-1-28556.

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Kelley, George A. Exercise and Osteoporosis: A Dose-Response Meta-Analysis. Fort Belvoir, VA: Defense Technical Information Center, May 2011. http://dx.doi.org/10.21236/ada554471.

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