Relevant bibliographies by topics / Osteoporosic fractures

Academic literature on the topic 'Osteoporosic fractures'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Osteoporosic fractures"

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Baccichetti, A., P. L. Nguyen-Thi, A. Blum, D. Mainard, F. Sirveaux, L. Nace, A. Valance, et al. "SAT0459 EVALUATION OF THE PREVALENCE AND THE MANAGEMENT OF OSTEOPOROTIC FRACTURES IN PATIENTS HOSPITALIZED AT NANCY UNIVERSITY HOSPITAL (FRANCE) IN 2017." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1187.1–1187. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3366.

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Background:Osteoporotic fractures are a major public health concern because of their consequences in morbidity, costs and mortality. In the meantime, historically postfracture osteoporosis medication use rates have been poor.Objectives:The aim is to analyze the management of osteoporosis in patients hospitalized for osteoporotic fractures (OF) at Nancy University Hospital (France) in 2017.Methods:Total number of hospitalized patients and hospital stays were extracted by the Department of Medical Information (DIM) which selected departments with at least forty hospitalizations with Medical Unit Summary related to a diagnosis of fracture or osteoporosis. Hospitalizations not concerned by a recent OF were excluded. Data on fractures, patient characteristics, risk factors for OF and fall, management of osteoporosis, discharge status, stay duration, were studied from patient medical records. Prevalence of OF stays, management of osteoporosis and factors associated with duration of stay were analyzed.Results:Out of a total of 153,840 hospitalizations, 918 hospitalizations (844 patients, mean age 74.5 years ± 13.6, 74.5% women) concern an OF. The prevalence of hospitalizations for OF was 0.6% of total hospitalizations and 17.9% of total hospitalizations for fractures. Among the 844 patients, 85.7% had a severe fracture (vertebral fracture: 56.2%, hip fracture: 24.1%), 16.5% had a non-severe fracture, and 8.5% had a fracture cascade in the year. At discharge from hospital, 11.7% of patients received a specific treatment for osteoporosis. Longer stay duration was associated with age, severe fractures, Groll index and discharge status.Conclusion:Nearly one hospitalized fracture in five is osteoporotic, while only one in ten patients is treated for osteoporosis. Stay duration increased with age and comorbidities. This encourages the development of early prevention, screening and treatment strategies for osteoporosis.References:[1]Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8:136.[2]Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006 Oct 19;17(12):1726–33.[3]Giangregorio L, Papaioannou A, Cranney A, Zytaruk N, Adachi JD. Fragility Fractures and the Osteoporosis Care Gap: An International Phenomenon. Semin Arthritis Rheum. 2006 Apr;35(5):293–305.Disclosure of Interests:None declared
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Murillo, Bernardo, Christian Antonio Allende Nores, and Orlando Rodríguez. "Incidencia de diagnóstico y tratamiento de la osteoporosis en pacientes con fractura de radio distal. [Diagnosis and treatment incidence of osteoporosis in patients with distal radius fractures]." Revista de la Asociación Argentina de Ortopedia y Traumatología 84, no. 2 (May 2, 2019): 99–104. http://dx.doi.org/10.15417/issn.1852-7434.2019.84.2.664.

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Introducción: Las fracturas de radio distal en pacientes mayores son un indicador de osteoporosis. El objetivo de este estudio fue determinar el diagnóstico y el tratamiento de la osteoporosis en pacientes con fractura de radio distal, operados en nuestra institución, entre 2012 y 2014.Materiales y Métodos: Los datos se obtuvieron de entrevistas telefónicas a 41 pacientes mayores, operados por fracturas de radio distal. Las variables evaluadas fueron: sexo, edad, enfermedades asociadas, tabaquismo, fracturas previas, tratamiento antiosteoporótico previo o posterior a la fractura en cuestión, especialidad del médico que solicitó el tratamiento y realización o no de densitometría mineral ósea.Resultados: La muestra incluyó a 41 pacientes (32 mujeres). Veintiséis contaban con una densitometría antes de la fractura (15 con osteoporosis), 11 habían sufrido una fractura por osteoporosis, y sólo 7 recibían tratamiento antiosteoporótico cuando ocurrió la fractura. Luego de la cirugía, solo 4 de ellos continuó con el tratamiento. Se encontró cierta asociación entre una densitometría patológica y la presencia de diabetes tipo 2, no así con otras comorbilidades. La tasa de incidencia anual de osteoporosis, calculada entre todos los pacientes que se atendieron en nuestra institución, en 2014, fue alrededor del 1%. Los traumatólogos solicitaron el 1,5% de todas las densitometrías prescritas dicho año.Conclusiones: Este estudio sugiere que los traumatólogos que se desempeñan en nuestra institución tienen nula o poca participación en la prevención secundaria de la osteoporosis; por esta razón, se consideraría necesario un protocolo de prevención de fracturas secundarias a la osteoporosis. Abstract Introduction: Distal radius fractures in elderly patients are an indicator of osteoporosis. The aim of this study was to determine osteoporosis diagnosis and treatment in patients with distal radius fractures treated surgically at our institution between 2012 and 2014.Methods:Information of 41 patients who had surgical intervention for distal radius fracture was obtained through telephones interviews. Several variables evaluated: age, sex, smoking, associated pathologies, previous fractures, preoperative and postoperative anti-osteoporotic treatments, specialty of the physicians that indicated antiosteoporotic treatment, and bone mineral density (BMD) studies performed.Results: The study included 41 patients (32 female).Twenty-six had a BMD performed before the fracture (15 evidenced osteoporosis), 11 had had previous fractures secondary to osteoporosis. Only 7patients were under anti-osteoporotic treatment to the moment of the fracture. After surgery, only 4 of the patients continued with the treatment. Pathological BMD had certain degree of associationwith the presence of Diabetes (type 2), but not with other comorbidities. The annual incidence rate of osteoporosis, calculated using all patients attended at our institution in 2014, was about 1%. Orthopedic surgeons indicated only 1.5% of the total number of BMDs prescribed that year.Conclusion: Our study suggests that there is poor prevention by orthopedic surgeons of secondary osteoporotic fractures, which is why a national prevention protocol for fractures secondary to osteoporosis would be considered necessary.
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Lyalina, V. V., I. A. Borshenko, S. V. Borisovskaya, E. A. Skripnichenko, R. V. Binyakovskiy, V. V. Trishina, and I. G. Nikitin. "Acute Osteoporotic Vertebral Fracture. Part 1. Definitions, Clinical Presentation, Pain Assessment, Diagnostic Imaging, Introduction to Differential Diagnosis." Russian Archives of Internal Medicine 12, no. 4 (July 30, 2022): 254–66. http://dx.doi.org/10.20514/2226-6704-2022-12-4-254-266.

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Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.
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Lyalina, V. V., I. A. Borshenko, S. V. Borisovskaya, E. A. Skripnichenko, R. V. Binyakovskiy, V. D. Solomin, V. V. Trishina, and I. G. Nikitin. "Acute Osteoporotic Vertebral Fracture. Part 2. Differential Diagnostics According to the Data of Imaging Methods. Conservative and Surgical Treatment." Russian Archives of Internal Medicine 12, no. 6 (November 29, 2022): 438–49. http://dx.doi.org/10.20514/2226-6704-2022-12-6-438-449.

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Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.
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Laffaire, M., M. Caroline, E. Allado, E. Bauer, I. Chary Valckenaere, and D. Loeuille. "AB0948 Osteoporotic screening and prevalence of severe osteoporotic fractures in a population of psoriatic arthritis initiating a biologic treatment." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1602.2–1603. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3871.

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BackgroundOsteoporosis is a common complication of Rheumatic diseases. The association between osteoporosis and rheumatoid arthritis is clearly demonstrated while this association is still debated as well as for the screening of osteoporosis by Dual-Energy X-Ray Absorptiometry (DEXA) or to demonstrate an increased risk of fracture on radiography in a population of Psoriatic Arthritis (PsA). The prevalence of fragility fractures reported on medical reports ranged between 12% and 40% in PsA patients. Only a few studies evaluated the prevalence of vertebral fracture (VF) on spine radiographs. To our knowledge no study has evaluated the contribution of radiographic or CT assessment of the spine on the prevalence of fragility fracture reported in medical records.ObjectivesTo determine Psoriatic Arthritis patient’s characteristics screened for osteoporosis by DEXA in a population initiating a biologic treatment (bDMARD) and to estimate the prevalence of severe osteoporotic fractures on medical reports and after imaging modalities scoring (X-ray or CT-scan).MethodsPatients with psoriasis should satisfy the CASPAR or ASAS criteria and have been screened during their follow up for a bDMARD. Osteoporotic screening was defined by a BMD testing (DEXA). Vertebral fractures were scored according to Genant’s method on spine X-ray or sagittal CT-scan images. Clinical and demographic data and the presence of previous severe osteoporotic fracture reported in the medical records were collected.ResultsOn 417 PsA patients screened for bDMARDs during 2008-2019, 89 patients (21.3%) were assessed for osteoporosis by DEXA. Increased age, female sex, menopause, previous severe fracture, disease duration, presence of inflammatory bowel disease, current and previous corticosteroid and bDMARDs uses were significantly associated with osteoporotic screening. On DEXA, 7 patients (7.9%) were classified as osteoporotic. The prevalence of severe osteoporotic fracture was 6.7% in medical reports and increased to 23.6% after scoring spine radiographies or TAP-CT images. In univariate analysis the presence of severe osteoporotic fractures was associated with age (p=0.013), scanographic bone attenuation coefficient (p=0.005) and Lumbar T-score (p=0.039).ConclusionLess than a quarter of PsA patients initiating a bDMARD is screened for osteoporosis. The prevalence of osteoporosis on DEXA and severe osteoporotic fractures on medical records are inferior to 10%. After systematic imaging evaluation, this prevalence increases at 23.6%.References[1]Chandran S, Aldei A, Johnson SR, Cheung AM, Salonen D, Gladman DD. Prevalence and risk factors of low bone mineral density in psoriatic arthritis: A systematic review. Seminars in Arthritis and Rheumatism. oct 2016[2]Riesco M, Manzano F, Font P, García A, Nolla JM. Osteoporosis in psoriatic arthritis: an assessment of densitometry and fragility fractures. Clinical Rheumatology. déc 2013[3]Pedreira PG, Pinheiro MM, Szejnfeld VL. Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis. Arthritis Res Ther. févr 2011[4]Del Puente A, Esposito A, Costa L, Benigno C, Del Puente A, Foglia F, et al. Fragility Fractures in Patients with Psoriatic Arthritis. The Journal of Rheumatology Supplement. 1 nov 2015[5]van der Weijden MAC, van der Horst-Bruinsma IE, van Denderen JC, Dijkmans BAC, Heymans MW, Lems WF. High frequency of vertebral fractures in early spondylarthropathies. Osteoporos Int. juin 2012[6]Pickhardt PJ, Pooler BD, Lauder T, del Rio AM, Bruce RJ, Binkley N. Opportunistic Screening for Osteoporosis Using Abdominal Computed Tomography Scans Obtained for Other Indications. Ann Intern Med. 16 avr 2013[7]Kwok TSH, Sutton M, Yang Ye J, Pereira D, Chandran V, Gladman DD. Prevalence and factors associated with osteoporosis and bone mineral density testing in psoriatic arthritis. Arthritis Care & Research. 16 déc 2020[8]Gulati AM et al. Osteoporosis in psoriatic arthritis: a cross-sectional study of an outpatient clinic population. RMD Open. juin 2018Disclosure of InterestsNone declared
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Ahn, Seong Hee, Seongbin Hong, Young J. Suh, Da Hea Seo, Yujin Jeong, Yongin Cho, and So Hun Kim. "ODP087 Dose-dependent effect of long-term statin use on risk of osteoporotic fracture in elderly patients." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A162. http://dx.doi.org/10.1210/jendso/bvac150.331.

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Abstract Introduction Studies have been conducted to assess the association between the use of statin and risk of new onset osteoporosis or osteoporotic fractures, however, they have shown conflicting results. We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in elderly population. Methods In this population cohort study with Korean National Health Insurance Service-Senior Cohort database, a total of 365,656 elderly (≥60 years) without previous history of osteoporosis were included. The patients who did not have a history of statin use in year 2003 were followed from January 2004 to December 2012. Incidences of major osteoporotic fractures and site specific fractures were compared using the Cox proportional hazards model with use the inverse probability weighting method. Results During years follow-up period, 54,959 major osteoporotic fractures occurred; the risk of major osteoporotic fractures was significantly reduced (OR,0.769; 95% CI,0.716-0.826) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for both vertebral fracture (OR,0.701; 95% CI,0.641-0.767) and non-vertebral fracture (OR,0.807; 95% CI,0.726-0.898). Longer duration and higher cumulative dose of statin, defined by cumulative daily defined dose, were negatively associated with the risk of major osteoporotic fracture. Conclusion In this population-based cohort study, the use of statin was associated with significant reduction in the risk of osteoporotic fractures in elderly patients without previous history of osteoporosis. Presentation: No date and time listed
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Dionyssiotis, Yannis, Grigorios Skarantavos, and Panayiotis Papagelopoulos. "Modern Rehabilitation in Osteoporosis, Falls, and Fractures." Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 7 (January 2014): CMAMD.S14077. http://dx.doi.org/10.4137/cmamd.s14077.

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In prevention and management of osteoporosis, modern rehabilitation should focus on how to increase muscular and bone strength. Resistance exercises are beneficial for muscle and bone strength, and weight-bearing exercises help maintain fitness and bone mass. In subjects at higher risk for osteoporotic fractures, particular attention should be paid to improving balance – the most important element in falls prevention. Given the close interaction between osteoporosis and falls, prevention of fractures should be based on factors related to bone strength and risk factors for falls. Fractures are the most serious complication of osteoporosis and may be prevented. The use of modern spinal orthosis helps to reduce pain and improve posture. Vibration platforms are used in rehabilitation of osteoporosis, based on the concept that noninvasive, short-duration, mechanical stimulation could have an impact on osteoporosis risk. Pharmacologic therapy should be added for those at high risk of fracture, and vitamin D/calcium supplementation is essential in all prevention strategies. Success of rehabilitation in osteoporotic and fractured subjects through an individualized educational approach optimizes function to the highest level of independence while improving the overall quality of life.
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Kerschan-Schindl, K., M. Hackl, E. Boschitsch, U. Föger-Samwald, O. Nägele, S. Skalicky, M. Weigl, J. Grillari, and P. Pietschmann. "Diagnostic Performance of a Panel of miRNAs (OsteomiR) for Osteoporosis in a Cohort of Postmenopausal Women." Calcified Tissue International 108, no. 6 (January 11, 2021): 725–37. http://dx.doi.org/10.1007/s00223-020-00802-3.

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AbstractA specific signature of 19 circulating miRNAs (osteomiRs) has been reported to be associated with fragility fractures due to postmenopausal osteoporosis. However, it is unknown whether osteoporotic fractures or low BMD phenotypes are independently contributing to changes in osteomiR serum levels. The first aim was to characterize the abundance, sensitivity to hemolysis, and correlation of osteomiR serum levels, the second objective to evaluate the diagnostic accuracy of osteomiRs for osteoporosis according to the WHO criteria and on basis of major osteoporotic fracture history. Fifty postmenopausal women with osteoporosis (with or without fragility fracture) and 50 non-osteoporotic women were included in this cross-sectional study. The diagnostic performance of osteomiRs for osteoporosis based on the WHO definition or fracture history was evaluated using multiple logistic regression and receiver-operator curve (AUC) analysis. The osteomiR® signature is composed of four clusters of miRNAs providing good performance for the diagnosis of osteoporosis in postmenopausal women defined by WHO criteria (AUC = 0.830) and based on history of major osteoporotic fractures (AUC = 0.834). The classification performance for the WHO criteria and for fracture risk is driven by miR-375 and miR-203a, respectively. OsteomiRs, a signature of 19 emerging miRNA bone biomarkers, are measurable in human serum samples. They constitute a panel of independent bone and muscle biomarkers, which in combination could serve as diagnostic biomarkers for osteoporosis in postmenopausal women.
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Belova, K. Yu, O. B. Yershova, A. A. Degtyarev, M. V. Belov, V. O. Gerasimov, and S. Yu Fedotov. "REFRACTURE PREVENTION SYSTEM: FIRST RESULTS OF A PILOT PROGRAM WITHIN THE PROJECT «PROMETHEUS» IN YAROSLAVL." Osteoporosis and Bone Diseases 17, no. 2 (December 15, 2014): 3–6. http://dx.doi.org/10.14341/osteo201423-6.

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In order to reduce the incidence of recurrent fractures in patients that had already experienced low-energy (osteoporotic) fracture, the International Osteoporosis Foundation initiated the program «Capture the fracture». Established Best Practice Framework represents 13 standards to evaluate the effectiveness of the centers for the prevention of recurrent fractures, organized in different countries. In 2012 the Russian Association on Osteoporosis started the project PROMETHEUS [Creation the system to prevent recurrence of fractures in patients with osteoporosis]. In order to implement this program in the city of Yaroslavl we conducted a pilot project to establish a center for the prevention of recurrent fractures in patients who have received osteoporotic fracture. In this article we assess the effectiveness of the work of this center with the use of international standards, identify key problems and propose solutions.
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Tile, Lianne, and Angela M. Cheung. "Atypical femur fractures: current understanding and approach to management." Therapeutic Advances in Musculoskeletal Disease 12 (January 2020): 1759720X2091698. http://dx.doi.org/10.1177/1759720x20916983.

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Osteoporosis and resulting osteoporotic fractures are responsible for significant morbidity, excess mortality, and health care costs in the developed world. Medical therapy for osteoporosis has been shown in multiple randomized controlled trials to reduce the risk of vertebral and non-vertebral fractures and hip fractures, and in some studies bisphosphonate medications have been associated with improved survival. Although the overall benefit to risk ratio of osteoporosis medications remains favorable, there have been concerns raised about the long-term safety of these treatments. Atypical femur fracture, which is a rare type of fracture that has been associated with the long-term use of potent antiresorptive bone medications, is a potentially devastating consequence of osteoporosis treatment. This paper reviews our current understanding of atypical femur fractures, their relationship to antiresorptive osteoporosis medications, and proposed strategies for management, in order to inform clinical decision making about the optimal use and duration of medical therapy for the treatment of patients with osteoporosis or at high risk for osteoporotic fractures.
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Dissertations / Theses on the topic "Osteoporosic fractures"

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Kaptoge, Stephen Kipkemoi. "Epidemiology of risk factors for osteoporosis and osteoporotic fractures." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615203.

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Braz, Manuela Giuliani Marcondes Rocha. "Sequenciamento paralelo em larga escala de genes candidatos para fragilidade óssea em indivíduos com osteoporose grave, familiar ou idiopática." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-22102018-123623/.

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A osteoporose é uma doença de alta prevalência na população geral, e a ocorrência de fraturas se associa a grande morbi-mortalidade e impacto econômico. Na maioria dos indivíduos afetados, a osteoporose tem etiologia multifatorial, com herdabilidade estimada entre 50 e 85%, atribuível a um conjunto de variantes genéticas de pequeno efeito individual. Raramente, há casos de osteoporose associada a síndromes monogênicas, decorrentes de defeitos genéticos de grande impacto. Postula-se que indivíduos com quadros extremos de osteoporose não sindrômica possam ter causa genética mono- ou oligogênica, atribuível a variantes de impacto intermediário sobre o fenótipo, ainda pouco reconhecidas. Nos últimos anos, o avanço das tecnologias de sequenciamento permitiu o reconhecimento de novos genes associados à fragilidade óssea e atualmente possibilita a análise simultânea de múltiplos genes. Neste contexto, os objetivos deste projeto de pesquisa foram: 1) buscar genes candidatos para fragilidade óssea previamente associados a doenças Mendelianas com alto impacto na resistência óssea, fenótipos extremos de osteoporose e estudos de associação genética em escala genômica (GWAS) para osteoporose; e 2) pesquisar a presença de variantes alélicas patogênicas nestes genes candidatos em indivíduos com osteoporose grave, familiar ou idiopática. A partir de revisão sistemática, 128 genes candidatos foram selecionados para compor um painel de sequenciamento paralelo em larga escala. O sequenciamento incluiu todos os éxons e 25 pares de bases das junções íntron-éxon. Foram consideradas variantes genéticas de interesse aquelas raras (frequência alélica < 1%) e com predição de alto impacto sobre a proteína codificada. Trinta e sete indivíduos (7 famílias e 21 casos isolados) foram selecionados seguindo critérios clínicos, laboratoriais e densitométricos restritivos, excluindo-se pacientes com causas secundárias de osteoporose. A coorte foi composta por homens em 54%, a mediana de idade ao diagnóstico foi 44 anos e 86% tinham histórico de fratura. Dentre os 28 casos índices, foram identificadas 33 variantes de interesse. Após análise de segregação familiar, foi possível excluir patogenicidade de cinco destas variantes, restando 28 variantes potencialmente patogênicas, presentes em 71% da coorte. Todas as variantes foram encontradas em heterozigose, sendo 26 variantes de ponto não-sinônimas, uma deleção de 9 pares de bases, e uma grande deleção envolvendo o único éxon codificador do gene candidato GPR68. Foi encontrada uma associação de variantes em genes diferentes em 21% da coorte, incluindo uma mulher jovem com osteoporose grave e variantes em WNT1, PLS3 e NOTCH2. A análise de segregação familiar neste caso sugeriu um efeito patogênico aditivo das variantes. Vinte e cinco porcento das variantes potencialmente patogênicas foram identificadas em genes candidatos bem estabelecidos (WNT1, PLS3, COL1A1, COL1A2), e 57% se localizam em novos genes candidatos identificados inicialmente por GWAS, como NBR1 e GPR68, também associados à alteração da remodelação óssea em modelos animais. Os resultados deste trabalho dão relevância a novos genes na fisiologia da resistência óssea e indicam um papel proeminente de interações digênicas/oligogênicas em casos de osteoporose grave, familiar ou idiopática. O reconhecimento de novas vias associadas à fragilidade óssea pode levar ao desenvolvimento de novos tratamentos, e a identificação de variantes patogênicas associadas à osteoporose pode, futuramente, permitir um manejo clínico personalizado de pacientes e seus familiares
Osteoporosis is a highly prevalent disorder resulting in fragility fractures and incurring in great morbi-mortality and economic burden. In most cases, osteoporosis has a multifactorial etiology, with an estimated heritability of 50-85% attributable to a combination of several low-impact genetic variants. Rarely, cases of syndromic osteoporosis due to high-impact genetic defects are seen. It is therefore hypothesized that severe/idiopathic cases of otherwise inconspicuous osteoporosis may have a monoor oligogenic etiology due to genetic variants with an intermediate effect. During the past years, advances in molecular sequencing have revealed novel candidate genes for bone fragility, and have enabled simultaneous sequencing of multiple genes. In this context, the objectives of this research project were: 1) to identify candidate genes for bone fragility, as previously reported in association to Mendelian disorders with high impact on bone resistance, idiopathic or familial osteoporosis, and genome-wide association studies (GWAS) for bone mineral density and fragility fractures; and 2) to perform molecular analysis of these candidate genes in patients with severe, familial or idiopathic osteoporosis. Through a systematic review, 128 candidate genes were identified and included in a panel for massively parallel sequencing. Coding regions and 25-bp boundaries were captured and sequenced. Rare variants (allele frequency < 1%), with a predicted high impact on protein function were initially selected as variants of interest. Thirty-seven subjects (21 sporadic cases and 7 families) were included according to stringent criteria based on clinical and densitometric evaluation, excluding individuals with secondary osteoporosis. Males represented 54% of the cohort, median age at diagnosis was 44 years, and 84% of subjects had a history of fractures. Thirtythree variants of interest were identified initially. After familial segregation analysis, 5 variants were considered as benign in regard to bone fragility, resulting in 28 potentially pathogenic variants, all heterozygous, present in 71% of the cohort. Of these variants, 26 were nonsynonymous, there was one 9-bp deletion and one large deletion involving the only coding exon of candidate gene GPR68. An association of two or more variants in different genes was present in 21% of the cohort, including a young woman with severe osteoporosis and variants in WNT1, PLS3 and NOTCH2. Familial segregation in this case suggested an additive pathogenic effect of these variants. Twenty-five percent of potentially pathogenic variants were identified in well-established candidate genes (WNT1, PLS3, COL1A1, COL1A2), and 57% located to novel candidate genes initially identified by GWAS, such as NBR1 and GPR68, which have been previously associated to changes in bone remodeling in mouse models. These results support the involvement of GWAS genes in the pathophysyiology of osteoporosis, and indicate a prominent role for digenic/oligogenic interactions in cases of severe, familial or idiopathic osteoporosis. Recognition of new molecular pathways in the determination of bone fragility may lead to the development of new drugs, and the identification of pathogenic variants associated to osteoporosis may allow individualized clinical management of patients and their relatives
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Ugarte, Corbalán Laura de 1988. "The regulatory roles of MicroRNAs in bone remodeling and osteoporosis." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565403.

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In bone field, microRNAs (miRNAs) have been described as key factors regulating bone formation, remodeling, and homeostasis. The identification of miRNAs involved in skeletal function will be essential to the development of miRNA-based therapeutic strategies for bone disorders. As with other regulatory molecules, miRNAs are frequently subject to change during the development of human diseases. In this regard, we identified a subset of miRNAs with altered expression in osteoporotic bone and demonstrate the functional involvement of some of those miRNAs in the regulation of bone formation and the pathways regulating the progression of osteoporosis. We also have depicted an overview of miRNAs in the human bone tissue and in primary bone cells. Furthermore, we have identified genetic variants in human osteoblast-related miRNAs associated with bone mineral density and this association was functionally demonstrated in bone and osteoblast samples. This work has provided evidences of the marked complexity behind this regulatory system and opens novel prospect for research and therapy.
En l’àmbit de l’estudi de l’òs, els microRNAs (miRNAs) han estat descrits com factors claus en la regulació de la formació, remodelatge i homeòstasis de l’ òs. La identificació de miRNAs implicats en la funció esquelètica és imprescindible pel desenvolupament de noves estratègies terapèutiques, basades en miRNAs, dirigides al tractament de malalties òssies. Com en el cas d’altres molècules reguladores, els miRNAs poden patir modificacions durant el desenvolupament de malalties humanes. En aquest sentit, hem identificat un grup de miRNAs amb una expressió alterada en l’òs osteoporòtic i hem demostrat la implicació funcional d’algun d’aquests miRNAs en la regulació de la formació òssia i els mecanismes pels quals es produiria l’osteoporosi. Alhora, també hem ofert una visió general dels miRNAs presents en el teixit ossi humà i en les cèl·lules òssies. També hem identificat variants genètiques dins de les seqüències de miRNAs expressats en osteoblasts, que han estat associades amb la densitat mineral òssia. A més a més, aquesta associació ha estat funcionalment demostrada en òs i osteoblasts. Aquest treball reflexa l’elevada complexitat que hi ha darrera del sistema regulador per miRNAs i obre nous camins per la recerca i la teràpia.
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Tan, Boon-Kiang. "Non-invasive determinants of osteoporotic fracture risk." University of Western Australia. Centre for Musculoskeletal Studies, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0125.

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[Truncated abstract] The cost of managing osteoporotic fractures places a significant financial burden on the health-care system. To reduce the fracture burden, early identification of fracture risk is essential to allow early intervention. The limitations associated with dual-energy X-ray absorptiometry (DXA), such as limited sensitivity and specificity, cost, ionising radiation and accessibility, have resulted in the emergence of other technologies for assessing bone fragility. An example is the portable and non-ionising quantitative ultrasound (QUS) technology. The discriminatory power of quantitative ultrasonometry in fracture risk identification, either independently or in combination with other established risk factors, currently remains contentious. It is recommended that fracture risk assessment should not only focus on bone status, but also on the risk of falls. Additionally, it has been noted that disability arising from osteoporotic fractures, even when these fractures are not identified clinically, can translate into psychosocial symptoms and a poorer perception of health-related quality of life (HRQoL). The primary aim of the present study was to investigate if a composite model comprising: calcaneal QUS, falls risk and HRQoL assessments, can identify a group of elderly women at high risk of osteoporotic fracture from those at lower risk. One hundred and four community-dwelling women (mean age 71.3 ±5.8 years) were recruited for this study. These women underwent a series of tests that included: DXA bone mineral density (BMD) evaluation of the proximal femur and lumbar spine (L1 L4); calcaneal QUS measurement; spinal radiography; rasterstereographic back surface curvature (BSC) examination; and performance-based assessment of strength, mobility and balance. The women were classified into a `High Risk’group or a `Low Risk’ group using three separate classification criteria: i) low BMD, based on the World Health Organisation (WHO) recommended T-score of < -2.5, and⁄or a history of fragility fracture (Osteoporotic [OP] group versus Non-Osteoporotic [NOP] group); ii) presence of at least one radiographically identified prevalent vertebral fracture (Vertebral Fracture [VF] group versus Non-Vertebral Fracture [NVF] group); or iii) a history of either forearm or wrist fracture (Forearm/Wrist Fracture [WF] group versus Non-Forearm/Wrist Fracture [NWF] group)
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Tavares, Bruna Filipa Gonçalves. "Prevenção da osteoporose." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1408.

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Introdução: A prevenção das fraturas osteoporóticas passa pela identificação dos indivíduos com fatores de risco clínicos para fratura, realização criteriosa da absorciometria de raio X de dupla energia (DEXA), tratamento anti-osteoporótico e follow-up dos doentes. Criada em 2008, validada para Portugal em 2012, a ferramenta FRAX® (WHO Fracture Risk Assessment Tool) calcula o risco de fratura da anca e de fratura major a 10 anos, ao integrar múltiplos fatores de risco. A National Osteoporosis Foundation (NOF) determinou dois limiares de alto risco, ≥3% e ≥20% respetivamente, que indicam a conduta para o tratamento farmacológico da osteopororse (OP), nos EUA. A adequação desses limiares tem sido objetivo de estudo por outros autores, mas não existem estudos na população portuguesa. O objetivo principal deste estudo foi determinar qual o limiar de risco, calculado através do FRAX®, que permite identificar com elevada sensibilidade os indivíduos com alto risco de fratura da anca, em Portugal. Métodos: De agosto a novembro de 2012, foi realizado um questionário e colheita de dados do processo clínico, de pacientes com pelo menos 50 anos, com fratura não traumática da extremidade proximal do fémur, internados no Serviço de Ortopedia do Hospital Pêro da Covilhã, do Hospital Sousa Martins e do Hospital Amato Lusitano. O risco de fratura da anca e o de fratura major foi calculado para cada paciente, através do FRAX® clínico (sem densidade mineral óssea - DMO) aferido para a população Portuguesa. Analisámos os limiares de risco FRAX® correspondentes a uma sensibilidade de 95% e 80% para a fratura incidente da anca. Resultados: Foram incluídos 138 doentes com fratura não traumática da anca. A média de idade foi 83,5±7,4 anos (81,2% mulheres). Os fatores de risco mais prevalentes foram: sexo feminino, idade superior a 65 anos, antecedentes pessoais e familiares de fratura de fragilidade e as causas de OP secundária. 91,2% dos doentes nunca tinham realizado uma DEXA e 89,8% não tinham realizado previamente medicação para a prevenção de fraturas. Os limiares de risco de FRAX® clínico de fratura da anca com sensibilidade de 80% e 95% para a fratura incidente da anca foram ≥5,5% e ≥3%, respetivamente. Conclusões: Identificámos os limiares adequados de alto risco para fratura osteoporótica da anca do instrumento FRAX® clínico numa população Portuguesa. Estes têm uma importante aplicação na prática clínica, pois permitem a melhor identificação dos indivíduos em risco, para seleção criteriosa dos que devem realizar ou não DEXA e tratamento farmacológico.
Introduction: The prevention of osteoporotic fractures involves the identification of the individuals with clinical risk factors for fracture, judicious performing of dual-energy x-ray absorptiometry (DXA), anti-osteoporotic treatment and patients’ follow-up. Created in 2008, validated for Portugal in 2012, the FRAX® tool (WHO Fracture Risk Assessment Tool) gives the 10-year probability of hip and major fracture, integrating multiple risk factors. The National Osteoporosis Foundation (NOF) determined two thresholds of high risk, ≥ 3% and ≥ 20% respectively, which indicates the treatment intervention of the OP, in USA. The adequacy of these thresholds has been the object of studies by other authors, but there aren’t any studies regarding the portuguese population. The main objective of this study was to determine the risk threshold, calculated using the FRAX® tool, which allows high sensitivity to identify individuals at high risk of hip fracture, in Portugal. Methods: From August to November 2012, a questionnaire and data collection from clinical process were performed to patients at least 50 years old, with nontraumatic hip fracture, admitted to the Orthopedics Service in Hospital Pêro da Covilhã, Hospital Sousa Martins and Hospital Amato Lusitano. The risk of hip fracture and the one of major fracture were calculated for each patient using the clinical FRAX® (without bone mineral density - BMD) measured for the Portuguese population. We analyzed the thresholds for risk FRAX® corresponding to a sensitivity of 95% and 80% for the incident hip fracture. Results: There were included 138 patients with non-traumatic hip fracture. The mean age was 83.5± 7.4 years (81.2% women). The most prevalent risk factors were: female gender, age over 65 years old, personal and parental history of fragility fracture and causes of secondary OP. 91.2% of patients had never performed DXA and 89.8% hadn’t previously made anti-osteoporotic treatment. The thresholds for high risk of hip fracture, by clinical FRAX®, with a sensitivity of 80% and 95% for the incident hip fracture were ≥5,5% and ≥3%, respectively. Conclusions: We identified appropriate thresholds at high risk for osteoporotic hip fracture, using FRAX® tool in the Portuguese population. These have an important application in clinical practice, as it allows a better identification of individuals at risk for careful selection of those who should perform DEXA and pharmacological treatment.
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Castillón, Bernal Pablo. "Implementación de una unidad de trauma geriátrico." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670446.

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Introducció L'any 1990 es van produir 1,6 milions de fractures de maluc a tot el món i s'estima que aquesta xifra augmentarà a 6 milions l'any 2050. A la Unió Europea es produeixen 600.000 fractures de maluc a l'any, aproximadament, amb un cost global anual de 13.000 milions d'Euros. La incidència a Espanya és de 517 casos per cada 100.000 habitants i per any. L'edat mitjana de 82 anys i un 78% dels pacients són de sexe femení. Els objectius del tractament de la fractura de maluc són preservar la vida i aconseguir una recuperació funcional que permeti el pacient integrar-se de nou en el seu medi habitual. Però, en aquests pacients, la taxa de mortalitat s'eleva durant el primer any d'un 8,4% a un 36%. A l'any de la fractura el 50% presenten dificultats per caminar, el 38-39% presenten dificultat per fer transferències i el 17-19% presenten dificultats per a l’higiene. Fins a un 90% dels pacients presenten múltiples comorbiditats, entre les quals la malaltia pulmonar obstructiva crònica, la demència, la hipertensió arterial, la patologia cardíaca isquèmica i la diabetis són les més comunes. Les característiques d'aquests pacients, ancians i amb múltiples comorbiditats, va fer sorgir la idea de proporcionar-los una atenció compartida entre cirurgians ortopèdics i geriatres. Aquesta idea inicial ha evolucionat a la tendència actual d'implementar unitats de ortogeriatria que integrin un tractament multidisciplinari. En aquest model a geriatres i traumatòlegs se sumen també anestesistes, rehabilitadors, fisioterapeutes, infermeres i nutricionistes, entre d'altres. Objectius L'objectiu principal d'aquesta tesi doctoral és determinar la demora per a intervenció quirúrgica dels pacients amb fractura de fèmur proximal després de la implementació d'una unitat de ortogeriatria. Els objectius secundaris són determinar el temps d'estada hospitalària, la mortalitat intrahospitalària i als 30 dies, i els reingressos que es produeixen per complicacions mèdiques i traumatològiques. Material i mètodes Durant l'any 2013 (juny-desembre), 2014 i 2015, van ingressar al nostre servei 534 fractures de maluc, de manera consecutiva. Mentre que en els anys 2011, 2012 i 2013 (gener-maig), quan encara no existia la Unitat de Traumatologia Geriàtrica (UTG) van ingressar 501. Les dades recollides prospectivament en el segon període, després de la implementació de la UTG, han estat comparats amb les dades dels pacients que van ingressar en el primer període. Resultats La demora mitjana per a ser intervingut quirúrgicament prèviament a la implementació de la UTG va ser de 2,27 dies (DE = 2,35), mentre que posteriorment va ser de 1,84 (DE = 1,73). (P = 0,0004). L'estada mitjana prèviament a la implementació de la UTG va ser de 11,39 dies (DE = 9,05), mentre que posteriorment va ser de 10,08 (DE = 5,43). (P = 0,0024). La mortalitat en els primers 30 dies després de la fractura de maluc, prèviament a la implementació de la UTG va ser del 7,7%, mentre que posteriorment va ser de l'4,8%. (P = 0,027). Conclusió La implementació d'una unitat de ortogeriatria, per al tractament dels pacients amb fractura de fèmur proximal, que inclou un conjunt de mesures entre les que destaquen la introducció de circuits ràpids de tractament, tractament multidisciplinari integrat i protocols de rehabilitació primerenca postoperatòria, ha permès disminuir de 2,27-1,84 dies el temps de demora mitjà per ser intervingut quirúrgicament després de l'ingrés. El temps d'estada hospitalària s'ha reduït en un temps mitjà d'un dia. La mortalitat dels pacients als 30 dies s'ha reduït en un 2,9%. Els reingressos per complicacions mèdiques o quirúrgiques no s'han incrementat.
Introducción En el año 1990 se produjeron 1,6 millones de fracturas de cadera en todo el mundo y se estima que esa cifra aumentará a 6 millones en el año 2050. En la Unión Europea se producen 600.000 fracturas de cadera al año, aproximadamente, con un coste global anual de 13.000 millones de Euros. La incidencia en España es de 517 casos por cada 100.000 habitantes y por año. La edad media de 82 años y un 78% de los pacientes son de sexo femenino. Los objetivos del tratamiento de la fractura de cadera son preservar la vida y conseguir una recuperación funcional que permita al paciente integrarse de nuevo en su medio habitual. Pero, en estos pacientes, la tasa de mortalidad se eleva durante el primer año de un 8,4% a un 36%. Al año de la fractura el 50% presentan dificultades para caminar, el 38-39% presentan dificultades para realizar transferencias y el 17-19% presentan dificultades para el aseo. Hasta un 90% de los pacientes presentan múltiples comorbilidades, entre las que la enfermedad pulmonar obstructiva crónica, la demencia, la hipertensión arterial, la patología cardiaca isquémica y la diabetes son las más comunes. Las características de estos pacientes, ancianos y con múltiples comorbilidades, hizo surgir la idea de proporcionarles una atención compartida entre cirujanos ortopédicos y geriatras. Esa idea inicial ha evolucionado a la tendencia actual de implementar unidades de ortogeriatría que integren un tratamiento multidisciplinar. En este modelo a geriatras y traumatólogos se suman también anestesistas, rehabilitadores, fisioterapeutas, enfermeras y nutricionistas, entre otros. Objetivos El objetivo principal de esta tesis doctoral es determinar la demora para intervención quirúrgica de los pacientes con fractura de fémur proximal tras la implementación de una unidad de ortogeriatría. Los objetivos secundarios son determinar el tiempo de estancia hospitalaria, la mortalidad intrahospitalaria y a los 30 días, y los reingresos que se producen por complicaciones médicas y traumatológicas. Material y métodos Durante el año 2013 (Junio-Diciembre), 2014 y 2015, ingresaron en nuestro servicio 534 fracturas de cadera, de forma consecutiva. Mientras que en los años 2011, 2012 y 2013 (Enero-Mayo), cuando todavía no existía la Unidad de Traumatología Geriátrica (UTG) ingresaron 501. Los datos recogidos prospectivamente en el segundo periodo, tras la implementación de la UTG, han sido comparados con los datos de los pacientes que ingresaron en el primer periodo. Resultados La demora media para ser intervenido quirúrgicamente previamente a la implementación de la UTG fue de 2,27 días (DE=2,35), mientras que posteriormente fue de 1,84 (DE=1,73). (p=0,0004). La estancia media previamente a la implementación de la UTG fue de 11,39 días (DE=9,05), mientras que posteriormente fue de 10,08 (DE=5,43). (p=0,0024). La mortalidad en los primeros 30 días tras la fractura de cadera, previamente a la implementación de la UTG fue del 7,7%, mientras que posteriormente fue del 4,8%. (p = 0,027). Conclusión La implementación de una unidad de ortogeriatría, para el tratamiento de los pacientes con fractura de fémur proximal, que incluye un conjunto de medidas entre las que destacan la introducción de circuitos rápidos de tratamiento, tratamiento multidisciplinar integrado y protocolos de rehabilitación temprana postoperatoria, ha permitido disminuir de 2,27 a 1,84 días el tiempo de demora medio para ser intervenido quirúrgicamente tras el ingreso. El tiempo de estancia hospitalaria se ha reducido en un tiempo medio de un día. La mortalidad de los pacientes a los 30 días se ha reducido en un 2,9%. Los reingresos por complicaciones médicas o quirúrgicas no se han incrementado.
Introduction In 1990, there were 1.6 million hip fractures worldwide. This number is expected to reach 6 million by 2050. In the European Union, osteoporosis causes approximately 600.000 hip fractures per year. The annual estimated economic burden for healthcare systems is 13.000 million Euros. The incidence of hip fractures in Spain is 517 cases per 100.000 inhabitants and year. The average age is 82 years and 78% are women. The goal of hip fracture treatment is to return the patient to preoperative levels of function, facilitating return to pre-fracture residence and supporting long-term wellbeing. Mortality rates in hip fracture patients rise from 8.4 to 36% in the first year after surgery. One year after the fracture, 50% have difficulties in walking, 38-39% are not able to transfer from a bed to a chair and 17-19% require aids for bathing and grooming. Up to 90% of patients have several comorbidities. Commonly, these include chronic obstructive pulmonary disease, dementia, high blood pressure, ischemic heart disease, and diabetes. Elderly patients with several comorbidities could benefit from shared care approaches provided by orthopedic surgeons and geriatricians. This cooperation has triggered the current trend of implementing orthogeriatric units that integrate multidisciplinary teams. In this model, several disciplines, besides surgeons and geriatricians, are involved in the care of the patients including anesthesiologists, physical therapists, nurses, and nutritionists. Objectives The main objective of this study is to determine the delay for surgical intervention of patients with proximal femur fracture after the implementation of an orthogeriatric unit. Secondary objectives are to determine the length of hospital stay, in-hospital and 30-day mortality, and readmissions resulting from medical and trauma complications. Material and methods During 2013 (June-December), 2014, and 2015, 534 consecutive hip fractures were treated in our hospital. While in 2011, 2012, and 2013 (January-May), before the orthogeriatric unit (OGU) was created, 501 hip fractures were treated. Data collected prospectively in the second period, after the implementation of the OGU, have been compared with the first period data. Results The mean delay to undergo surgery before the implementation of the OGU was 2.27 days (SD = 2.35), compared to 1.84 (SD = 1.73). (p = 0.0004) for the second period. The average in-hospital stay before the implementation of the OGU was 11.39 days (SD = 9.05), compared to 10.08 (SD = 5.43). (p = 0.0024) after the orthogeriatric model of care was established. 30-day mortality rate after hip fracture, before OGU implementation, was 7.7%, and 4.8% afterward. (p = 0.027). Conclusion The implementation of an orthogeriatric unit for the treatment of patients with a hip fracture which requires a series of measures including the introduction of fast treatment circuits, integrated multidisciplinary treatment, and early postoperative rehabilitation protocols, has allowed a decrease from 2.27 to 1.84 days in the average time to surgery after admission. The length of hospital stay was reduced by an average time of one day. 30-day mortality was reduced by 2.9%. Readmissions for medical or surgical complications did not increase.
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Misra, Devyani. "Warfarin use and risk of osteoporotic fractures." Thesis, Boston University, 2012. https://hdl.handle.net/2144/21219.

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Thesis (M.S.M.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
OBJECTIVE: Prior studies examining the association of warfarin use and osteoporotic fractures have found conflicting results and have had methodological problems, such as confounding by indication and confounding by duration of warfarin use. Thus, we studied the association of warfarin use with fractures at the hip, spine and wrist, among older men and women with atrial fibrillation recruited from the general population, using rigorous statistical tools to overcome challenges faced by prior studies. METHODS: We included men and women ≥65 years with incident atrial fibrillation, without history of fracture, followed between 2000-2010 from The Health Improvement Network (THIN). Long-term warfarin use was defined in two ways: 1) warfarin use ≥ 1year; 2) warfarin use ≥3 years. Non-use was defined as no use of warfarin over the follow-up period. Propensity scores (PS) for warfarin use were calculated using logistic regression with long-term use of warfarin as the dependent variable and age, sex, body mass index (BMI), history of multiple falls, deep venous thrombosis, pulmonary embolism, heart failure, neuropsychiatric impairment, hyperthyroidism, estrogen use, beta blockers, corticosteroids, bisphosphonates, smoking and alcoholism as independent variables. Each warfarin user was then matched by PS to a non-user by the “greedy matching” method. Incidence rates were calculated for warfarin users and non-users. The association between long-term warfarin use and risk of hip, spine and wrist fractures was evaluated using Cox-proportional hazards models. RESULTS: Incidence rates of hip fracture were 5.21 and 6.20 per 1000 person-years among subjects with warfarin use >1 (n=20,346) and >3 (n=11,238) years, respectively. The hazard ratios of hip fracture for warfarin use >1 and >3 years were 1.08 (95% CI 0.87, 1.35) and 1.13 (95% CI: 0.84, 1.5), respectively. Similar findings were observed between warfarin use and risk of spine or wrist fracture. CONCLUSIONS: Long-term use of warfarin among older adults with atrial fibrillation is not associated with increased risk of osteoporotic fractures and thus, does not necessitate additional surveillance or prophylaxis.
2031-01-01
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Hillier, Sharon Lee. "Water fluoridation and osteoporotic hip fracture." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264665.

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Borgström, Fredrik. "Health economics of osteoporosis /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-781-2/.

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Guedj, Emmanuel. "Les fractures du sacrum par insuffisance osseuse." Montpellier 1, 1995. http://www.theses.fr/1995MON11050.

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Books on the topic "Osteoporosic fractures"

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name, No. Vertebral osteoporotic compression fractures. Philadelphia, PA: Lippincott Williams & Wilkins, 2002.

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Genant, Harry K. Vertebral fracture in osteoporosis. Edited by Jergas Michael and Van Kuijk Cornelis. San Francisco, Calif: University of California, San Francisco, 1995.

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Obrant, Karl, ed. Management of Fractures in Severely Osteoporotic Bone. London: Springer London, 2000. http://dx.doi.org/10.1007/978-1-4471-3825-9.

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Griffin, Jane. Osteoporosis and the risk of fracture. London: Office of Health Economics, 1990.

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Takahashi, Hideaki E., David B. Burr, and Noriaki Yamamoto, eds. Osteoporotic Fracture and Systemic Skeletal Disorders. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5613-2.

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Razi, Afshin E., and Stuart H. Hershman, eds. Vertebral Compression Fractures in Osteoporotic and Pathologic Bone. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33861-9.

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Sinaki, Mehrsheed. Non-Pharmacological Management of Osteoporosis: Exercise, Nutrition, Fall and Fracture Prevention. Cham: Springer International Publishing, 2017.

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Ringe, Johann. Osteoporotic fractures in the elderly: Clinical management and prevention. Stuttgart: Georg Thieme Verlag, 1996.

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Vereniging, Osteoporose, ed. Osteoporose: Patiëntenrichtlijn osteoporose en het voorkomen van botbreuken. 3rd ed. [Amsterdam]: Stichting September, 2011.

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Wendlova, Jaroslava. Biomechanical variables in assessment of fracture risk. Hauppauge, N.Y: Nova Science, 2011.

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Book chapters on the topic "Osteoporosic fractures"

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Bartl, Reiner, and Bertha Frisch. "Osteoporotic Fractures." In Osteoporosis, 165–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-79527-8_23.

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Vialle, Luiz R., and Emiliano N. Vialle. "Osteoporotic Fractures." In Essentials of Spine Surgery, 61–68. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80356-8_10.

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Bartl, Reiner, and Bertha Frisch. "Risk Factors for Fractures." In Osteoporosis, 45–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-79527-8_5.

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Hamdy, Ronald C. "Fracture Risk Assessment." In Osteoporosis, 46–61. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118316290.ch4.

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Marques, Andréa Ascenção. "Osteoporosis and Fractures." In Perspectives in Nursing Management and Care for Older Adults, 65–78. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-18012-6_5.

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Lasanianos, Nick G., George K. Triantafyllopoulos, and Spiros G. Pneumaticos. "Osteoporotic Vertebral Fractures." In Trauma and Orthopaedic Classifications, 251–54. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6572-9_56.

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Maes, Menno. "Osteoporosis — Insufficiency Fractures." In Spinal Imaging, 235–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-68483-1_10.

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Tosounidis, Theodoros H., and Michael G. Kontakis. "Osteoporotic ankle fractures." In Surgical and Medical Treatment of Osteoporosis, 261–66. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429161087-27.

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Ong, Terence, and Opinder Sahota. "Osteoporotic thoracolumbar fractures." In Surgical and Medical Treatment of Osteoporosis, 305–14. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429161087-31.

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Telera, Stefano, Laura Raus, Valerio Pipola, Federico De Iure, and Alessandro Gasbarrini. "Osteoporotic Vertebral Fractures." In Vertebral Body Augmentation, Vertebroplasty and Kyphoplasty in Spine Surgery, 133–48. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76555-2_9.

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Conference papers on the topic "Osteoporosic fractures"

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Kasra, Mehran, Marc D. Grynpas, Rajka Soric, and Sara Arnaud. "A Clinical Evaluation of Vibration Testing in the Assessment of Osteoporosis." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2587.

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Abstract Bone fracture is one of the most common medical problems which reduces the quality of life of individuals. In the United States, osteoporosis alone causes 1.3 million bone fractures a year, with an annual cost of $5.2 billion dollars. Osteoporosis is a disease in which low bone mass and changes in bone quality and architecture increase the risk of fractures. Women are at greater risk of developing osteoporosis than men. Osteoporosis targets both trabecular and cortical bone (Kanis et al., 1994; Kasra and Grynpas, 1994). Therefore, bone density of cortical bone structures such as ulna and mid-radius may be used as a predictor of osteoporotic fractures (Cummings et al., 1993). Bone quality assessment and predicting the risk of bone fracture is very important in prevention of fracture and proper bone treatment. In the NIH Consensus Development Statement (1984), the need for improved measurement techniques is emphasized.
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Higgins, Kathryn B., Robert D. Harten, Noshir A. Langrana, and Alberto M. Cuitino. "Biomechanics of Vertebroplasty." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32635.

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Osteoporosis is a skeletal disease characterized by low bone mass and deterioration of bone tissue. It affects 15–20 million women in the United States. Fractures of the vertebrae, wrist and hip are the most common. [1] In the spine, osteoporosis greatly affects the bone mass of the vertebral bodies (VB), the primary structures for transmitting loads in the spine. The VB is comprised of a shell of dense bone surrounding a more porous bony tissue called trabecular bone. Trabecular bone is a lattice-like network of trabeculae in the shape of plates or rods, depending on orientation and one’s age. When the weakened trabecular structure experiences a loss of height, acute back pain, spinal cord compression, and overall loss of mobility can ensue. A single fracture creates a region of high stress in the trabecular network, often leading to more fractures. In almost 20% of the cases one fracture in a VB may result in a secondary fracture within a one year period. [2] Many fractures go unnoticed. The high occurrence, frequent uncertainty of fracture, and gravity of subsequent injury indicate a need to improve the strength of osteoporotic vertebrae before damage can occur. It may be desirable to treat weakened bone prior to fracture. One candidate for prevention that is investigated in this study is vertebroplasty. Currently, the procedure is used to repair fractured VB by injecting acrylic bone cement into the affected level. A parametric finite element (FE) investigation and supporting experimental study was conducted to evaluate the usefulness of vertebroplasty as a preventative treatment.
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Ferreri, Suzanne, and Yi-Xian Qin. "Dynamic Mechanical Signals Delivered by Ultrasound Generate Site Specific Mediation of Bone Loss." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206219.

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Osteoporosis is a disease characterized by decreased bone mass and progressive erosion of the microstructure. As a result, bone is at higher risk for developing chronic and traumatic fractures at key skeletal sites. Therapeutic ultrasound may offer a potential non-pharmacologic, site-specific intervention for treatment of osteoporotic bone loss.
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"An Informative Machine-Learning Tool for Diagnosis of Osteoporosis using Routine Femoral Neck Radiographs." In InSITE 2019: Informing Science + IT Education Conferences: Jerusalem. Informing Science Institute, 2019. http://dx.doi.org/10.28945/4350.

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Aim/Purpose: The aim of the study was to analyze the structure of the bone tissue by using texture analysis of the bone trabeculae, as visualized in a routine radiograph of the proximal femur . This could provide objective information regarding both the mineral content and the spatial structure of bone tissue. Therefore, machine-learning tools were applied to explore the use of texture analysis for obtaining information on the bone strength. Background: One in three women in the world develops osteoporosis, which weakens the bones, causes atraumatic fractures and lowers the quality of life. The damage to the bones can be minimized by early diagnosis of the disease and preventive treatment, including appropriate nutrition, bone-building exercise and medications. Osteoporosis is currently diagnosed primarily by DEXA (Dual Energy X-ray Absorptiometry), which measures the bone mineral density alone. However, bone strength is determined not only by its mineral density but also by the spatial structure of bone trabeculae. In order to obtain valuable information regarding the bone strength, the mineral content and the spatial structure of the bone tissue should be objectively assessed. Methodology: The study includes 17 radiographs of in-vitro femurs without soft tissue and 44 routine proximal femur radiographs (15 subjects with osteoporotic fractures and 29 without a fracture). The critical force required to fracture the in-vitro femurs was measured and the bones were divided into two groups: 11 solid bones with critical fracture force higher than 4.9kN and 6 fragile bones with critical fracture force lower than 4.9kN. All the radiographs included an aluminum step-wedge for calibrating the gray-levels values (See Figure 3). An algorithm was developed to automatically adjust the gray levels in order to yield equal brightness and contrast. Findings: The algorithm characterized the in-vitro bones with as fragile or solid with an accuracy of 88%. For the radiographs of the patients, the algorithm characterized the bones as osteoporotic or non-osteoporotic with an accuracy of 86%. The most prominent features for estimating the bone strength were the mean gray-level, which is related to bone density, and the smoothness, uniformity and entropy, which are related to the spatial distribution of the bone trabeculae. Impact on Society: Analysis of bone tissue structure, using machine-learning tools will provide a significant information on the bone strength, for the early diagnosis of osteoporosis. The structure analysis can be performed on routine radiographs of the proximal femur, with high accuracy. Future Research: The algorithm for automatic structure analysis of bone tissue as visualized on a routine femoral radiograph should be further trained on a larger dataset of routine radiographs in order to improve the accuracy of assessing the bone strength.
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Salas, Christina, Meir Marmor, Thomas Chu, Paul Hansma, Amir Matityahu, and Jenni M. Buckley. "Assessment of Local Bone Quality of the Distal Radius Using a Novel Hard Tissue Diagnostic Instrument." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206823.

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Senile osteoporosis has been defined as a skeletal disorder characterized by a deterioration of bone matrix with an increase in susceptibility to fracture with increasing age (1). Studies have shown that over 25 million Americans are currently afflicted with osteoporosis and/or osteopoenia, with this number doubling by 2020. (2) (3) With the propensity for fracture being large in older osteoporotic patients, quantification of bone mineral density (BMD) is essential for proper implant selection in the event of a fracture. Dual energy x-ray absorptiometry (DEXA) is the clinical gold standard for BMD assessment; however, the hardware associated with this technique is neither portable nor appropriate for intraoperative use, and both of these qualities are occasionally necessary clinically.
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Tawackoli, Wafa, Gemunu Gunaratne, Fazle Hussain, and Michael Liebschner. "Dynamic Response of Normal and Osteoporotic Trabecular Bone by Vibration Analysis." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-81982.

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Osteoporosis afflicts about 200 million people worldwide; and osteoporotic fractures are in the millions annually in the US alone and cost tens of billions of dollars [1]. Characterization of bone quality in osteoporotic patients is important with respect to monitoring treatment efficacy, though currently quite limited. While some technical hurdles in developing a noninvasive diagnostic tool using low frequency vibration have been overcome, changes in the frequency response signal of bone have not been investigated at the various bone organizational levels. Our principal hypothesis is that the vibrational modes of bone tissue change significantly with the deterioration of bone micro-architecture and that these modes can be captured by noninvasive sensors.
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Ural, Ani. "Evaluation of Fracture Load in Human Radius via Cohesive Finite Element Modeling." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204316.

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Osteoporotic and age-related fractures are a significant public health problem. One of the most common osteoporotic fracture sites in the aging population is distal radius. There is evidence in the literature that distal radius fractures (Colles’ fracture) are an indicative of increased risk of future spine and hip fractures [1]. Therefore, developing new methods for accurate evaluation of human radius fracture risk is necessary. The previous studies showed that geometrical properties of the radius correlate with its fracture load [2]. However, the combined effect of geometrical and material properties on fracture load has not been studied.
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Natella, LL, N. Bronsard, J. Allia, L. Hekayem, L. Euller-Ziegler, F. De Peretti, and V. Breuil. "FRI0578 Odontoid fractures in the elderly: an unknown osteoporotic fracture?" In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3503.

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M Benneker, Lorin. "Osteoporotic Spine Fractures." In eccElearning Postgraduate Diploma in Spine Surgery. eccElearning, 2017. http://dx.doi.org/10.28962/01.3.122.

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Ardatov, Oleg, Vladimir Barsukov, and Dmitriy Karev. "Stress analysis of osteoporotic femur." In Biomdlore. VGTU Technika, 2016. http://dx.doi.org/10.3846/biomdlore.2016.10.

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Osteoporosis and degenerative diseases cause low bone mass that increases fracture risks. This study presents the modelling of osteoporotic femur by employing finite element method (FEM). The loading of femur using FEM tools was performed. The level of degradation was modelled by changing the thickness of cortical shell and using power-law equations, which determine the dependence between apparent density of cancellous bone and its mechanical properties. Obtained results could be useful for both medical diagnosis and bone health check.
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Reports on the topic "Osteoporosic fractures"

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Xiang, Kemeng, Huiming Hou, and Ming Zhou. The efficacy of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates on postmenopausal women with osteoporosis:A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0067.

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Review question / Objective: The aim of this review is to evaluate the effectiveness of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates for postmenopausal osteoporosis. Condition being studied: Postmenopausal osteoporosis (PMOP) is a disorder of bone metabolism caused by estrogen deficiency in women after menopause, which manifests clinically as pain, spinal deformities and even fragility fractures, affecting the quality of life of patients and possibly shortening their life span. Bisphosphonates are commonly used to control and delay the progression of the disease, improve the patient's symptoms and reduce the incidence of fragility fractures. However, single drugs are still lacking in controlling the progression of the disease, and the combination of drugs is the clinical priority.
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Mao, wei, Ai-guo LI, Fei DONG, Sheng Nan QIN, Pei liang he, guowei huang, and huan chen. Risk factors for secondary fractures to percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0128.

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Yokota, Hiroki. Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada613289.

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Yokota, Hiroki. Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada570122.

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Dong, Depeng, Jiajun Huang, Dongxiang Chen, Liang Li, Zhiyong Huang, Dawei Luo, and Wenhui Zhang. Kiva augmentation technique versus balloon kyphoplasty for Osteoporotic vertebral compression fracture. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0068.

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Feng, Ningning, Jianbin Guan, Xing Yu, Wenhao Li, Tao Liu, Guozheng Jiang, Kaitan Yang, Yongdong Yang, and He Zhao. Jintiange Capsule May Have a Positive Effect in OVCF Patients with percutaneous vertebral augmentation: A Meta-Analysis of Randomized Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0038.

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Review question / Objective: We aimed to conduct a meta-analysis of the effects of JTG capsules on patients with OVCF underwent PVA surgery, focusing on clinical outcomes and drug safety. Condition being studied: This meta-analysis aims to systematic evaluation of clinical efficacy and adverse effects of JTG with PVA in the treatment of osteoporotic vertebral compression fracture (OVCF).Our current evidence suggests that JTG capsule may relieve pain in OVCF patients who underwent PVA surgery, improve functional activity, and increase BMD, particularly in patients under the age of 70, as well as increase BGP levels.However, considering the unsatisfactory quality of the included trials, more high-quality trials are needed to prove this issue.
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Fink, Howard A., Roderick MacDonald, Mary L. Forte, Christina E. Rosebush, Kristine E. Ensrud, John T. Schousboe, Victoria A. Nelson, et al. Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), April 2019. http://dx.doi.org/10.23970/ahrqepccer218.

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Wang, Qiang, Changtai Sun, Liang Zhang, Lin Wang, Quan Ji, Nan Min, and Zilong Yin. High- Vs Low-Viscosity Cement Vertebroplasty For Osteoporotic Vertebral Compression Fracture: A Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0110.

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Li, Tong, Yiran Wang, Qiang Ran, Yang Yu, Leiming Jiang, Yin Shi, Qun Zhou, and Xiaohong Fan. Unilateral curved percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0001.

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Sun, Hai-Bo, Jian-Lin Shan, and Hai Tang. Percutaneous Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures Will Increase the Number of Subsequent Fractures at Adjacent Vertebral Levels: A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0097.

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