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1

Grifka, Joachim, and Darrell J. Ogilvie-Harris, eds. Osteoarthritis. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-87752-0.

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Schumacher, H. Ralph, ed. Osteoarthritis. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73878-4.

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3

Reginster, J. Y., J. P. Pelletier, J. Martel-Pelletier, Y. Henrotin, and L. Crasborn. Osteoarthritis. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-60026-5.

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Kapoor, Mohit, and Nizar N. Mahomed, eds. Osteoarthritis. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19560-5.

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5

D, Brandt Kenneth, Doherty M. M. D, and Lohmander Stefan, eds. Osteoarthritis. Oxford: Oxford University Press, 1998.

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6

Don, Brown. Osteoarthritis. Seattle, WA: Natural Product Research Consultants, 1997.

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7

D, Brandt Kenneth, Doherty M. M. D, and Lohmander Stefan, eds. Osteoarthritis. Oxford: Oxford University Press, 2003.

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8

A, Johnston Spencer, ed. Osteoarthritis. Philadelphia: W.B. Saunders Co., 1997.

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9

National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.), ed. Osteoarthritis. Bethesda, Md: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 1999.

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10

P, Stitik Todd, ed. Osteoarthritis. Philadelphia: Hanley & Belfus, Inc., 2001.

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11

C, McCarty Eric, and Miller Mark D, eds. Osteoarthritis. Philadelphia: Saunders, 2005.

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12

W, Moskowitz Roland, ed. Osteoarthritis. Philadelphia: Saunders, 1993.

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13

D, Brandt Kenneth, ed. Osteoarthritis. Philadelphia: Saunders, 2003.

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14

Lattermann, Christian, Henning Madry, Norimasa Nakamura, and Elizaveta Kon, eds. Early Osteoarthritis. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-79485-9.

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15

Nigel, Arden, and Cooper Cyrus, eds. Osteoarthritis handbook. London: Taylor & Francis, 2006.

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16

Sabatini, Massimo, Philippe Pastoureau, and Fr�d�ric De Ceuninck. Cartilage and Osteoarthritis. New Jersey: Humana Press, 2004. http://dx.doi.org/10.1385/1592598102.

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De Ceuninck, Fr�d�ric, Massimo Sabatini, and Philippe Pastoureau. Cartilage and Osteoarthritis. New Jersey: Humana Press, 2004. http://dx.doi.org/10.1385/1592598218.

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18

Arden, Nigel, Francisco Blanco, C. Cooper, Ali Guermazi, Daichi Hayashi, David Hunter, M. Kassim Javaid, Francois Rannou, Frank Roemer, and Jean-Yves Reginster. Atlas of Osteoarthritis. Tarporley: Springer Healthcare Ltd., 2014. http://dx.doi.org/10.1007/978-1-910315-16-3.

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19

Westendorf, Jennifer J., and Andre J. van Wijnen, eds. Osteoporosis and Osteoarthritis. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-1619-1.

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20

Odella, Simona. Trapeziometacarpal Joint Osteoarthritis. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-44336-2.

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21

Tanaka, Seisuke, and Chiaki Hamanishi, eds. Advances in Osteoarthritis. Tokyo: Springer Japan, 1999. http://dx.doi.org/10.1007/978-4-431-68497-8.

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22

Bronner, Felix, and Mary C. Farach-Carson, eds. Bone and Osteoarthritis. London: Springer London, 2007. http://dx.doi.org/10.1007/978-1-84628-701-5.

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23

van Wijnen, Andre J., and Marina S. Ganshina, eds. Osteoporosis and Osteoarthritis. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0989-7.

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24

Westendorf, Jennifer J., and Andre J. Van Wijnen. Osteoporosis and osteoarthritis. New York: Humana Press, 2015.

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25

Felix, Bronner, and Farach-Carson Mary C. 1958-, eds. Bone and osteoarthritis. London: Springer, 2007.

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26

Felix, Bronner, and Farach-Carson Mary C. 1958-, eds. Bone and osteoarthritis. London: Springer, 2007.

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27

1930-, Tanaka S., and Hamanishi C. 1946-, eds. Advances in osteoarthritis. Tokyo: Springer, 1999.

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28

Brandt, Kenneth D. Diagnosis of osteoarthritis. Summit, N.J: CIBA-GEIGY, 1993.

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29

T, Felson David, and Schaible H. -G, eds. Pain in osteoarthritis. Hoboken, N.J: John Wiley & Sons, 2008.

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30

E, Kuettner Klaus, Goldberg Victor M. 1939-, American Academy of Orthopaedic Surgeons., and American Academy of Orthopaedic Surgeons. Symposium., eds. Osteoarthritic disorders: Workshop, Monterey, California, April 1994. Rosemont, IL: The Academy, 1995.

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31

Doherty, Michael. Osteoarthritis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0266.

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Osteoarthritis (OA) is a disorder of synovial joints and is characterized by the combination of focal hyaline cartilage loss and accompanying subchondral bone remodelling and marginal new bone formation (osteophyte). It has genetic, constitutional, and environmental risk factors and presents a spectrum of clinical phenotypes and outcomes. OA commonly affects just one region (e.g. knee OA, hip OA). However, multiple hand interphalangeal joint OA, usually accompanied by posterolateral firm swellings (nodes), is a marker for a tendency towards polyarticular ‘generalized nodal OA’.
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32

Javaid, Kassim, and Paul Wordsworth. Osteoarthritis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.010007.

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♦ Osteoarthritis is the outcome of many different disease processes♦ Correlation between radiographic appearance and symptoms is poor♦ Prevalence increases rapidly with age♦ A multidimensional approach in treatment should include patient education, physical therapy, analgesia, and ergonomic assessment♦ Surgical approaches to treatment should adopt a holistic approach.
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33

Osteoarthritis. Elsevier, 2007. http://dx.doi.org/10.1016/b978-0-323-03929-1.x5001-0.

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34

Osteoarthritis. Gordon Soules Book Pub, 1989.

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35

Osteoarthritis. Philadelphia: Saunders, 1999.

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36

Osteoarthritis. Oxford University Press, Incorporated, 2014.

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37

Osteoarthritis. Island Press, 1999.

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38

Osteoarthritis. Consumer Education Publishing, 1997.

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39

Miller, Marc L. Osteoarthritis. Jones & Bartlett Learning, LLC, 2009.

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40

Arden, Nigel, David J. Hunter, and Daniel Prieto-Alhambra. Osteoarthritis. Oxford University Press, 2014.

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41

A, Johnston Spencer, ed. Osteoarthritis. 1997.

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42

Chen, Qian. Osteoarthritis. DI Press, 2022.

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43

Alexander, Lori, NetCE, and CE Resource. Osteoarthritis. CE Resource, Incorporated, 2019.

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44

Arden, Nigel K., and Elizabeth Arden. Osteoarthritis. Oxford University Press, 2008.

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45

Osteoarthritis. W.B. Saunders Company, 2010.

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46

Osteoarthritis. CE Resource, Incorporated, 2022.

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47

Rinaldis, Toi. Osteoarthritis Book : Steps for Deal with Osteoarthritis: Osteoarthritis Best Treatment. Independently Published, 2021.

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48

REY, Neily. Osteoarthritis: Fitness Routines to Cure Osteoarthritis. Independently Published, 2021.

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49

Bjornberg, Josiah. Osteoarthritis Book : Steps for Deal with Osteoarthritis: Osteoarthritis Stem Cell Treatment. Independently Published, 2021.

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50

Wenham, Claire Y. J., and Philip G. Conaghan. Osteoarthritis—management. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0140.

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Osteoarthritis (OA) is a common condition which often causes pain and functional limitation, significantly impacting on a person's quality of life. A comprehensive assessment of the impact of OA should be performed before selecting therapies and treatment goals. Current recommended therapies include a combination of pharmacological and non-pharmacological therapies, which should be considered for all people with OA, regardless of anatomical site of involvement. Non-pharmacological treatments include education, muscle strengthening and aerobic exercises, weight loss if appropriate, splints and devices, and aids. Pharmacological therapies include paracetamol, oral and topical non-steroidal anti-inflammatory drugs, topical capsaicin, intra-articular corticosteroid injections, and opioids. Many existing therapies have only a small analgesic effect size and, in the case of drug therapies, may be associated with important side effects, so an individual's symptoms and comorbidities must be taken into account when selecting therapies. For those who do not respond to these treatments, surgery such as a total joint arthroplasty may be required. There is a strong need for new analgesic treatments for OA. As it is becoming increasingly clear that the sources of pain in OA are complex and multifactorial, future treatments for OA will need to target both peripheral and central pain mechanisms.
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