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1

YAMANA, YUSUKE, TAKESHI HAYASHIBARA, MASAKI YAMAMOTO, and DAVIN H. E. SETIAMARGA. "First observation of the "double-faced X-framed cup ossicle" extracted from a deep sea holothurian in Japan." Zoosymposia 15, no. 1 (October 21, 2019): 203–11. http://dx.doi.org/10.11646/zoosymposia.15.1.21.

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A New type ossicle form, “double-faced x-framed cup ossicle” is discovered from the undescribed deep sea holothuroid. To give a definite view on the substantial qualities of this ossicle, a SEM observation on the ossicles and a DNA barcoding analysis are conducted. Although the most internal and external morphologies of the present species agree well with the characteristics of the family Cucumariidae Ludwig, 1894, the ossicles morphologies mostly does not agree with the congeners of Cucumariidae. On the other hand, our molecular study indicates a possibility that the specimens are not cucumariids, but belong to a sister group of Cucumariidae. In our present observation, some of the peri-oral ossicles show a very similar property with the small x-framed cup-shaped structures (which sometimes occurs in cucumariids). Therefore, the double-faced x-framed cup ossicle probably could be considered as the results of derivation from the x-body: in which four extra-arms developed on the bottom face of a cup ossicle, and finally these arms equipped with an extra-rim.
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2

Taylor, Lawrence H., Brian K. Hall, and David K. Cone. "Experimental infection of yellow perch (Perca flavescens) with Apophallus brevis (Digenea, Heterophyidae): parasite invasion, encystment, and ossicle development." Canadian Journal of Zoology 71, no. 9 (September 1, 1993): 1886–94. http://dx.doi.org/10.1139/z93-269.

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Yellow perch (Perca flavescens) were exposed to cercariae of Apophallus brevis collected from naturally infected snails and maintained for up to 63 d postinfection (PI). Histochemistry revealed that attachment, penetration, migration, and encystment were complete by 2 d PI. By 14 d PI, a precursor to a host ossicle capsule surrounded the encysted metacercaria. Between 14 and 63 d PI a calcified matrix aggregated in a specific developmental pattern of islets, crescent, band, then ring, within an equatorial band at the cyst–capsule interface. The result was an ossicle ring of calcified tissue separating two uncalcified-matrix poles. Ossicle rings thickened and advanced over the cyst, but did not seal it off completely, forming an intermediate ossicle 49 d PI with two polarized canals. Pigmentation of ossicles through the appearance of melanocytes was not consistent between infections of the same age. Scanning electron microscopy revealed two distinct regions within fully developed ossicles. Randomly distributed interstitial fibres and ovoid and tubular lacunae surrounded by perilacunar collars formed the inner cellular region. The interstitial fibres within the outer region formed acellular/lamellar bands.
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3

Queiroz, Kevin de, and David A. Good. "The Scleral Ossicles of Opisthocomus and Their Phylogenetic Significance." Auk 105, no. 1 (January 1, 1988): 29–35. http://dx.doi.org/10.1093/auk/105.1.29.

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Abstract Dried scleral rings of Opisthocomus, Galliformes, Cuculiformes, and other birds were examined to determine the pattern of ossicle overlap in Opisthocomus and its bearing on the phylogenetic relationships of this taxon. Although Opisthocomus shares a derived number of 12 scleral ossicles with cuculid Cuculiformes, the pattern of ossicle overlap differs. Nevertheless, fewer modifications are required to derive the number and pattern of ossicles in Opisthocomus from the conditions in cuculid or musophagid Cuculiformes than from the conditions in any galliform. Our findings also indicate that the scleral rings of birds, unlike those of lizards, often do not conserve overlap relations between adjacent ossicles during phylogeny.
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4

Smith, Kevin M., and Matt B. Welch. "Painful Os Intermetatarseum." Journal of the American Podiatric Medical Association 100, no. 3 (May 1, 2010): 213–15. http://dx.doi.org/10.7547/1000213.

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Accessory ossicles are usually benign radiographic findings. However, they may become clinically significant if they fracture or cause soft-tissue irritation. An os intermetatarseum is an uncommon ossicle found between the bases of the first and second metatarsals. This article reviews some of the theories relating to the development of this uncommon ossicle and describes its role as a possible etiology of metatarsus primus varus. (J Am Podiatr Med Assoc 100(3): 213–215, 2010)
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5

Dudda, Ravi, Sowmya Tumkur Rangaiah, M. Hanumantha Prasad, and Nagavara Kalegowda Balaji. "Correlation between degree of hearing loss and intraoperative findings in tubotympanic type of chronic suppurative otitis media." International Journal of Otorhinolaryngology and Head and Neck Surgery 4, no. 2 (February 23, 2018): 537. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20180717.

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<p class="abstract"><strong>Background:</strong> The aim of tympanoplasty done for tubotympanic type of chronic suppurative otitis media (CSOM) should not only be to achieve a dry ear, but also to give hearing improvement to the patient. Aim of this study was to determine the correlation between size and site of tympanic membrane perforation with degree of hearing loss and correlation between ossicular chain status and degree of hearing loss on pure tone audiometry.</p><p class="abstract"><strong>Methods:</strong> Patients with tubotympanic CSOM with hearing loss upto 60 dBHL undergoing tympanoplasty were examined to know the site and size of tympanic membrane(TM) perforation. Intraoperative findings pertaining to middle ear and ossicles were noted. </p><p class="abstract"><strong>Results:</strong> Out of 52 patients of tubotympanic type of CSOM, hearing loss was least (31.18±7.46 dBHL) in small perforations of the TM and highest in subtotal perforations (48.74±7.83 dBHL) which was statistically significant. Hearing loss was significantly more in posterior perforation (46.61±7.02 dBHL) than in anterior perforation of TM (32.65±8.77 dBHL).<strong> </strong>There was a statistically significant difference in pure tone average hearing loss between intact ossicle group (32.87±9.77 dBHL)<strong> </strong>and eroded ossicle group (43.39±9.60dBHL). Difference in air bone gap was also significant between intact ossicle group (24.09±9.56 dB) and eroded ossicle group (31.02±9.83 dB). Multiple ossicles were eroded in nineteen patients with incus being the most commonly eroded ossicle.</p><p><strong>Conclusions:</strong> In this study, hearing loss increased with increased size of TM perforation and also with posterior perforation. Incus was found to be the most commonly eroded ossicle. Multiple ossicles were seen eroded most commonly when hearing loss was moderate. The surgeon will be better equipped to do ossiculoplasty in view of these preoperative findings and also to counsel the patient better about their expectation of hearing improvement following surgery. </p>
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6

Park, Chul Hyun, and JeongJin Park. "Effect of Modified Broström Procedure With Periosteal Flap Augmentation After Subfibular Ossicle Excision on Ankle Stability." Foot & Ankle International 40, no. 6 (March 13, 2019): 656–60. http://dx.doi.org/10.1177/1071100719837230.

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Background: The study evaluated the clinical and radiographic outcomes of the modified Broström procedure (MBP) with periosteal flap augmentation after large subfibular ossicle excision for chronic lateral ankle instability (CLAI). Methods: Twenty-two CLAI cases with a large ossicle (≥10 mm) were treated consecutively using the MBP with periosteal flap augmentation after ossicle excision. The mean follow-up duration was 20 months (12-33). For clinical assessment, the visual analog scale (VAS), American Orthopaedic Foot & Ankle Society (AOFAS) score, and Karlsson-Peterson score were evaluated preoperatively and at the last follow-up. For radiographic assessment, the size of the ossicle was measured by magnetic resonance imaging, and the talar tilt angle and anterior talar displacement were measured preoperatively and at the last follow-up. Results: The VAS, AOFAS, and Karlsson-Peterson scores improved from 6.3, 68.7, and 56.9 preoperatively to 1.6, 94.5, and 92.4 at the last follow-up, respectively. The mean size of the ossicles was 14.8 mm (11-21 mm). The talar tilt angle and anterior talar displacement improved from 11.2 degrees and 8.3 mm preoperatively to 4.4 degrees and 3.9 mm at the last follow-up, respectively. Conclusion: MBP combined with periosteal flap augmentation after ossicle excision provided good clinical and radiographic outcomes in CLAI with a large ossicle. Level of Evidence: Level IV, case series.
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7

Comeau, Ariane, Cory D. Bishop, and Christopher B. Cameron. "Ossicle development of the crinoid Florometra serratissima through larval stages." Canadian Journal of Zoology 95, no. 3 (March 2017): 183–92. http://dx.doi.org/10.1139/cjz-2016-0195.

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Crinoids are the oldest living class of echinoderm and sister group to the remaining eleutherozoan clade and so are key to discussions on the evolution and development of the echinoderm skeleton. Here we present the intraspecific variation of ossicle development of the feather star Florometra serratissima (A.H. Clark, 1907) during its three larval stages: doliolaria, cystidean, and early pentacrinoid. To induce settlement, larvae were cultured on a sea table in glass bowls containing coralline algae. The soft tissues of 60 larvae were dissolved to isolate and to observe the ossicles with compound microscopy and scanning electron microscopy. From the late doliolaria stage to 56-day-old pentacrinoids, a total of four types of ossicle developed: oral plates, basal plates, columnar stalk ossicles, and an attachment disk. Occasionally, an additional plate was found under the basal plates, which may represent a vestigial infrabasal plate. The shape of the attachment disk was plastic to accommodate the substrate. Crinoid ossicle development is variable in size, shape, and number, and the timing of development is asynchronous; traits that may have contributed to the early rapid radiation and phenotypic disparity of echinoderms.
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8

Dairaghi, Jacob, Dan Rogozea, Rachel Cadle, Joseph Bustamante, Leni Moldovan, Horia I. Petrache, and Nicanor I. Moldovan. "3D Printing of Human Ossicle Models for the Biofabrication of Personalized Middle Ear Prostheses." Applied Sciences 12, no. 21 (October 31, 2022): 11015. http://dx.doi.org/10.3390/app122111015.

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The middle ear bones (‘ossicles’) may become severely damaged due to accidents or to diseases. In these situations, the most common current treatments include replacing them with cadaver-derived ossicles, using a metal (usually titanium) prosthesis, or introducing bridges made of biocompatible ceramics. Neither of these solutions is ideal, due to the difficulty in finding or producing shape-matching replacements. However, the advent of additive manufacturing applications to biomedical problems has created the possibility of 3D-printing anatomically correct, shape- and size-personalized ossicle prostheses. To demonstrate this concept, we generated and printed several models of ossicles, as solid, porous, or soft material structures. These models were first printed with a plottable calcium phosphate/hydroxyapatite paste by extrusion on a solid support or embedded in a Carbopol hydrogel bath, followed by temperature-induced hardening. We then also printed an ossicle model with this ceramic in a porous format, followed by loading and crosslinking an alginate hydrogel within the pores, which was validated by microCT imaging. Finally, ossicle models were printed using alginate as well as a cell-containing nanocellulose-based bioink, within the supporting hydrogel bath. In selected cases, the devised workflow and the printouts were tested for repeatability. In conclusion, we demonstrate that moving beyond simplistic geometric bridges to anatomically realistic constructs is possible by 3D printing with various biocompatible materials and hydrogels, thus opening the way towards the in vitro generation of personalized middle ear prostheses for implantation.
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9

Rupa, V., H. Krishnaswami, and A. Job. "Autograft ossicle selection in cholesteatomatous ear disease: histopathological considerations." Journal of Laryngology & Otology 111, no. 9 (September 1997): 807–9. http://dx.doi.org/10.1017/s0022215100138691.

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AbstractIn order to determine whether selection of autograft ossicles in cholesteatomatous ear disease should be based on upon their apperance under the surgical operating microscope, we studied the histopathological features of 113 such ossicles. We attempted to correlate the extent of erosion of the ossicle, as noted under the surgical operating microscope, with their histopathological apperance. There were 60 mallei and 53 incudes. Seventy-nine ossicles were eroded and 34 were intact. The commonest abnormality noted was erosion of the long process of the incus (75 per cent). Both intact and eroded ossicles had similar histological features. There was no evidence of intra-ossicular cholesteatoma. The results suggest that the extent of erosion of these ossicles as seen under the surgical operating microscope should in no wasy prejudice their use as autografts when required.
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10

Lee, Doo Jae, Dong Yeon Lee, and Jae Hee Lee. "Clinical significance and morphological analysis of the os subfibulare using radiologic assessment in patients with chronic lateral ankle instability." Foot & Ankle Orthopaedics 3, no. 3 (July 1, 2018): 2473011418S0030. http://dx.doi.org/10.1177/2473011418s00305.

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Category: Ankle Introduction/Purpose: Although os subfibulare has been associated to various clinical problems in patients with chronic lateral ankle instability (CLAI), there are a few studies on the analysis of morphological characteristics of os subfibulare. The purpose of this study is to analyze morphologic characteristics of the os subfibulare and to evaluate the clinical significance of the os subfibulare in patients with CLAI. Methods: Among 252 patients who visited our training hospital with the symptom of lateral ankle instability for more than 1 year after sustaining ankle injury, 71 patients with os subfibulare who underwent magnetic resonance imaging (MRI) of the ankle were included in this study. For each patient, the simple radiologic assessment was also performed. The shape and size of ossicles were measured on a sagittal MR images. The location of the subfibular ossicle was classified into 3 zones by relation with the attachment site of the anterior talofibular ligament. The talofibular impingement, in which ossicles impinged to the talar articular surface. Results: The most common shape of ossicles was oval, and the most common site of ossicles was ATFL attach site. 61% of patients showed talofibular joint impingement on axial MR images, whereas 28 cases showed normal congruency of the talofibular joint. Forty-eight cases in 71 patients with CLAI had an enlarged fibular shape instead of a contralateral fibula on simple radiographs. The age; sex; the shape, location, and size of the ossicle; talofibular articular impingement; and history of major trauma were associated with surgical treatment in statistical analysis. Conclusion: The morphological analysis of the os subfibulare revealed that the ossicle manifested radiographic differences based on its size, location, and morphology. Based on the findings of our study, we suggest it is crucial to understand the morphologeical characteristics of the os subfibulare in patients with CLAI and to establish the treatment plan accordingly.
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11

Lee, Doo Jae, Hyuck Soo Shin, Jae Hee Lee, Min Gyu Kyung, Kyoung Min Lee, and Dong Yeon Lee. "Morphological Characteristics of Os Subfibulare Related to Failure of Conservative Treatment of Chronic Lateral Ankle Instability." Foot & Ankle International 41, no. 2 (October 30, 2019): 216–22. http://dx.doi.org/10.1177/1071100719884056.

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Background: The os subfibulare is usually asymptomatic and found incidentally on radiographs. However, sometimes it may cause subfibular pain and may be associated with chronic lateral ankle instability (CLAI). We hypothesized that os subfibulare could interrupt the talofibular space causing impingement, resulting in chronic pain and functional instability around the lateral malleolus. The purposes of this study were to analyze morphologic characteristics of os subfibulare, and to evaluate the clinical significance of the os subfibulare in patients with CLAI. Methods: Between November 2011 and April 2015, 70 patients who had both computed tomography (CT) and magnetic resonance imaging (MRI) among 252 patients who visited our hospital with the symptom of lateral ankle instability were included in this study. The location of the ossicle was classified into 3 zones in reference to the attachment site of the lateral ankle ligaments. The impingement was classified into 2 groups according to the presence of talofibular encroachment. Digital radiographs were used to measure the ossicle width and shape determined by the length and width on an magnetic resonance (MR) image. Results: The most common shape of ossicles was oval, and the most common location of ossicles was at the anterior talofibular ligament (ATFL) attachment site. Sixty-one percent of patients showed talofibular impingement on coronal MR images. In 48 cases, the dimension of fibula plus os subfibulare was larger than that of the contralateral normal fibula. The larger size and talofibular impingement of the ossicle were associated with greater need for operative treatment in patients with ankle instability. Conclusion: The morphologic analysis of the os subfibulare revealed that there might be impingement of the talofibular space by the ossicle in some patients. We suggest that morphologic characteristics of the os subfibulare should be considered when selecting treatment options in patients with CLAI and os subfibulare. Level of Evidence: Level III, retrospective comparative series.
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12

Shlepr, M., and R. L. Turner. "Early ossicle growth in the regenerating disc of a brittle star." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 364–65. http://dx.doi.org/10.1017/s0424820100169559.

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Calcification in the echinoderms occurs within a limited-volume cavity enclosed by cytoplasmic extensions of the mineral depositing cells, the sclerocytes. The current model of this process maintains that the sheath formed from these cytoplasmic extensions is syncytial. Prior studies indicate that syncytium formation might be dependent on sclerocyte density and not required for calcification. This model further envisions that ossicles formed de novo nucleate and grow intracellularly until the ossicle effectively outgrows the vacuole. Continued ossicle growth occurs within the sheath but external to the cell membrane. The initial intracellular location has been confirmed only for elements of the echinoid tooth.The regenerating aboral disc integument of ophiophragmus filograneus was used to test the current echinoderm calcification model. This tissue is free of calcite fragments, thus avoiding questions of cellular engulfment, and ossicles are formed de novo. The tissue calcification pattern was followed by light microscopy in both living and fixed preparations.
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13

Song, Junhui, Mark J. Kiel, Zhou Wang, Jingcheng Wang, Russell S. Taichman, Sean J. Morrison, and Paul H. Krebsbach. "An in vivo model to study and manipulate the hematopoietic stem cell niche." Blood 115, no. 13 (April 1, 2010): 2592–600. http://dx.doi.org/10.1182/blood-2009-01-200071.

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Abstract Because the microenvironment that supports hematopoietic stem cell (HSC) proliferation and differentiation is not fully understood, we adapted a heterotopic bone formation model as a new approach for studying the HSC microenvironment in vivo. Endogenous HSCs homed to tissue-engineered ossicles and individually sorted HSCs from ossicles were able to reconstitute lethally irradiated mice. To further explore this model as a system to study the stem cell niche, ossicles were established with or without anabolic parathyroid hormone (PTH) treatment during the 4-week course of bone development. Histology and micro–computed tomography showed higher bone area-to-total area ratios, thicker cortical bone and trabecular bone, significantly higher bone mineral density and bone volume fraction in PTH-treated groups than in controls. By an in vivo competitive long-term reconstitution assay, HSC frequency in the ossicle marrow was 3 times greater in PTH groups than in controls. When whole bone marrow cells were directly injected into the ossicles after lethal irradiation, the PTH-treated groups showed an enhanced reconstitution rate compared with controls. These findings suggest the residence of HSCs in heterotopic bone marrow and support the future use of this ossicle model in elucidating the composition and regulation of the HSC niche.
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14

O’Loughlin, P. Mark, Anna Stępień, Marek Kuźniak, and Didier Van Den Spiegel. "A new genus and four new species of sea cucumbers (Echinodermata) from Admiralty Bay, King George Island." Polish Polar Research 34, no. 1 (March 1, 2013): 67–86. http://dx.doi.org/10.2478/popore-2013-0003.

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Abstract Four new Antarctic holothuroid species are described for specimens from Admiralty Bay in King George Island. A new genus Dendrelasia O’Loughlin is erected for new cucumariid species Dendrelasia sicinski with dendrochirotid body form and elasipodid− type spinous rod ossicles. Cucumariid Staurocucumis krzysztofi has bowl ossicles predominantly with marginal teeth. Provisionally−assigned thyonid Allothyone presleri has table ossicles with spires comprising predominantly four pillars. Molpadiid Molpadia magdae has a prickly cover of irregular table ossicle spires and fusiform table discs in both body wall and tail. Staurocucumis liouvillei (Vaney) is a “species complex”
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15

Lawande, MaliniA, Sidhartha Tavri, DeepakP Patkar, SonaA Pungavkar, and Jayant Narang. "Meniscal ossicle." Indian Journal of Radiology and Imaging 18, no. 2 (2008): 128. http://dx.doi.org/10.4103/0971-3026.40294.

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16

Lee, Ju Hong, Sung Il Wang, and Young Ran Jung. "Meniscal Ossicle." Journal of the Korean Orthopaedic Association 51, no. 2 (2016): 173. http://dx.doi.org/10.4055/jkoa.2016.51.2.173.

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17

Rohilla, Seema, Rohtas K. Yadav, Raj Singh, Ashish Devgan, and Dhara B. Dhaulakhandi. "Meniscal ossicle." Journal of Orthopaedics and Traumatology 10, no. 3 (July 10, 2009): 143–45. http://dx.doi.org/10.1007/s10195-009-0056-4.

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18

Wake, M., J. M. Robinson, A. L. Sheehan, S. Bazerbachi, and B. W. Codling. "The histology of ‘stored’ autologous ossicles." Journal of Laryngology & Otology 106, no. 1 (January 1992): 17–20. http://dx.doi.org/10.1017/s0022215100118481.

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AbstractControversy still exists concerning the ultimate fate of transposted or transplanted ossicles in tympanoplasty. Histological studies on autologous and homologous ossicles removed at revision operations, or from animal studies, vary in their conclusions. The viability, of such materials used in the long-term is still uncertain. Whether this has any functional significance is also uncertain.This report contains a histological review of 10 ossicle remnants stored in the ‘closed’ mastoid cavity for 12 months, following closed cavity mastoidectomy (combined approach tympanoplasty)
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19

Hossain, Mohammad Delwar, Md Nasir Uddin Ahamed, Mohammad Misbah Al Kabir Sumon, and Bhuiyan ARM Shoyeb. "Status of Ossicles in Cholesteatoma." Bangladesh Journal of Otorhinolaryngology 21, no. 2 (May 7, 2016): 97–101. http://dx.doi.org/10.3329/bjo.v21i2.27648.

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The study was conducted to detect and analyze the different types of ossicular chain defect in chronic suppurative otitis media with cholesteatoma on mastoid exploration and to identify the ossicle most commonly eroded by the disease process. A total 60 cases of CSOM with cholesteatoma of different age groups, who underwent surgery were included in this study and their intra operative ossicular chain findings were noted. 100% cases were presented with long standing aural discharge. It was observed that cholesteatoma was more common in male (60%) than female (40%) and 53.33% patients were in young age group (21-35 years). 90% cases showed ossicular erosion while only 10% cases showed intact ossicles. The incus was found to be absent in 15% cases and eroded in 75% cases. And the malleus was observed as the most resistant ossicle to be eroded.Bangladesh J Otorhinolaryngol; October 2015; 21(2): 97-101
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20

Narita, Callum, and Paul Marovic Marovic. "Painful Os Intermetatarseum: Abnormal MRI imaging findings." International Journal of Sport, Exercise and Health Research 5, no. 1 (May 30, 2021): 28–29. http://dx.doi.org/10.31254/sportmed.5108.

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Accessory ossicles are a common incidental finding on imaging of the feet. Os intermetatarseum is one such ossicle. These mostly remain asymptomatic; however, pain syndromes associated with accessory ossicles are a known entity and the diagnosis of painful os syndrome should be considered in undifferentiated foot pain. Whilst use of imaging in the diagnosis of painful os syndromes of the foot is well substantiated, there is little available literature on the use of magnetic resonance imaging (MRI) in the diagnosis of painful os intermetatarseum. We report a case of painful os intermetatarseum with MRI findings that have not previously been described
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21

Park, Moon Suh, and Hun Ki Min. "Laser Soldering and Welding for Ossicular Reconstruction: An in Vitro Test." Otolaryngology–Head and Neck Surgery 122, no. 6 (June 2000): 803–7. http://dx.doi.org/10.1016/s0194-59980070005-2.

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To evaluate the possibility of laser application in ossicular reconstruction, soldering and welding of bony tissue with proteineous materials was performed by using a Co2 laser, and the bonding strength of these materials was measured with a gradual weighing system. The soldered and welded surface of bone was observed with a scanning electron microscope. Additionally, welding of human ossicles and synthetic materials was experimentally tried with lasers, and morphologic changes were observed and recorded. A scanning electron microscopic examination was also done. A 40% albumin solution and commercial fibrin glue showed the best bonding strength. Bridging of denatured protein solder may be a mechanism of bonding. Polycel was melted by using a laser beam, and melted Polycel covered the surface of the ossicle. However, the bonding strength was not enough to use, and exact measurement of bonding strength was not possible. These results suggested the possibility of laser soldering and welding in ossicular reconstruction, especially with ossicle or cortical bone.
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22

Gage, J. D. "Skeletal growth bands in brittle stars: microstructure and significance as age markers." Journal of the Marine Biological Association of the United Kingdom 70, no. 1 (February 1990): 209–24. http://dx.doi.org/10.1017/s0025315400034329.

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Skeletal growth banding has been studied in the vertebral arm ossicles of the shallowwater brittle stars Ophiothrix fragilis, Amphiura filiformis, A. chiajei, Ophiura ophiura and O.albida collected from near Oban. Scanning electron microscopy of ossicle microstructure show the bands reflect differences in stereom porosity and surface relief on the surface of the wing-like fossae of the ossicle. The evidence supports the interpretation of the bands as annual growth markers, with coarse-pored stereom laid down during periods of active growth in summer/autumn whilst finer-pored stereom, that often forms ‘breaking wave’- like ridges, is formed during periods of slow or negligible skeletal growth during the rest of the year. Growth curves fitted to growth ring measurements indicate three contrasting growth strategies amongst the species examined. These data generally support recent interpretations of demographic structure reached from studies of size frequencies in samples collected from other areas in the NE Atlantic range of these species.
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23

Blake, Daniel B. "Early Asterozoan (Echinodermata) Diversification: A Paleontologic Quandary." Journal of Paleontology 87, no. 3 (May 2013): 353–72. http://dx.doi.org/10.1666/12-042.1.

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The Asterozoa as traditionally recognized is monophyletic, although ancestry within the Echinodermata is unknown. The asterozoan class Somasteroidea is most readily recognized by presence of series of simple ossicles termed virgals that extend laterally from each ambulacral ossicle. Virgal series reduction to two or three together with ossicular specializations provide apomorphies of the class Stenuroidea (new ranking). Both asteroid-like and ophiuroid-like configurations as well as expressions less suggestive of those of the surviving classes emerged within stenuroids during an early period of diversification. The classes Ophiuroidea and Asteroidea are separate lineages marked by virgal series reduction to a single ossicle and other ambulacral column specializations. It is uncertain whether one or both surviving classes were derived directly from somasteroids or originated through stenuroids. All three of the derived asterozoan classes can be argued to be either monophyletic and thereby justifying class status, or alternatively either paraphyletic or polyphyletic and thereby indicative of multiple plesions; here, monophyletic class-level status is favored for all three.
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24

Hotz, M. A., and R. H??usler. "Ossicle Homografts Revisited." Laryngoscope 113, no. 7 (July 2003): 1274–75. http://dx.doi.org/10.1097/00005537-200307000-00030.

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25

Reck, Rolf, Heinz Broemer, and Klaüs‐Konrad Deutscher. "Auditory ossicle prosthesis." Journal of the Acoustical Society of America 77, no. 4 (April 1985): 1632. http://dx.doi.org/10.1121/1.391984.

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26

Krause, John O., and Andrew M. Rouse. "Accessory Calcaneus: A Case Report and Literature Review." Foot & Ankle International 16, no. 10 (October 1995): 646–50. http://dx.doi.org/10.1177/107110079501601012.

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A case of bilateral accessory calcanii is presented in which the accessory ossicle articulated with the talus and calcaneus at the lateral aspect of the posterior facet of the subtalar joint, causing premature subtalar degenerative changes in a 19-year-old man. Although rare and usually asymptomatic, accessory ossicles around the foot may need surgical excision if painful or if sufficient size is obtained to cause deformity and/or limitations in range of motion.
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Kumar, Puneeth, Amit Kumar Dey, Kartik Mittal, Rajaram Sharma, and Priya Hira. "Double Meniscal Ossicle, the First Description: CT and MRI Findings—Different Etiologies." Case Reports in Radiology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/737506.

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We present a case of 2 ossicles in the medial meniscus with emphasis on MRI and CT findings. Meniscal ossicle is a rare entity and is quite uncommon on the medial side. By showing the typical signal characteristics and intrameniscal location, MRI can be helpful in distinguishing this from other more clinically significant abnormalities. It should be kept as differential from synovial chondromatosis or sesamoid bones like fabella as management is different for all of these entities.
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Devgan, Ashish, Reetadyuti Mukhopadhyay, Amanpreet Singh, Paritosh Gogna, Rohit Singla, and Narender Kumar Magu. "Ossicle in Anterior Cruciate Ligament: A Rare Occurrence." Case Reports in Orthopedics 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/616715.

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The occurrence of an intra-articular ossicle is not rare in the knee, with reports suggesting the existence of meniscal osscile. There are also reports describing the attachment of the posterolateral bundle of the anterior cruciate ligament (ACL) to an accessory ossicle. However, despite an extensive search of the English literature we did not find much written about an intrasubstance ossicle in the ACL. We present the case of a 13-year-old male with an intrasubstance ossicle in the anteromedial bundle of the ACL of his right knee.
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Gamble, James G., Charles M. Chan, Lawrence A. Rinsky, Steven L. Frick, and Kevin G. Shea. "THE UTILITY OF MRI IN CLINICAL DECISION-MAKING FOR PEDIATRIC ATHLETES WITH SYMPTOMATIC SUBFIBULAR OSSICLES." Orthopaedic Journal of Sports Medicine 8, no. 4_suppl3 (April 1, 2020): 2325967120S0023. http://dx.doi.org/10.1177/2325967120s00230.

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Background: Pediatric athletes commonly sustain inversion-type ankle fractures.1,2 Approximately 1% will form post-traumatic subfibular ossicles (SO), especially after tip avulsion fractures.3,4 Athletes with SOs can have pain and recurrent sprains.5,6,7 Here we show the utility of magnetic resonance imaging (MRI) in clinical decision-making for athletes with ankle symptoms and the presence of a SO. Our hypothesis is that MRI can predict which athletes have a stable SO and will respond to non-operative management, and which athletes have an unstable SO and will need surgery. Methods: We performed an IRB approved retrospective cohort study. Children were eligible from our practices if (1) they had radiographic evidence of a SO, (2) they had symptoms of pain and recurrent sprains, and (3) they had undergone MRI during their clinical evaluation. We identified 19 eligible children (20 ankles;) eight girls and eleven boys, ages 5–19 years. Nine involved the left ankle; 11 the right ankle. Most frequent sport was soccer (12/16) followed by basketball (3/14.) From the radiograph we determined ossicle size and location. MRI images were considered positive if fluid-sensitive sequences showed a high-intensity signal between the SO and the fibular epiphysis. Main outcome was treatment (non-surgical or surgical) relative to the MRI findings. Results: Size shape and location: Size and shape were variable. Width ranged from 2 – 10.4 mm and length from 4 – 13.5 mm. Concerning location all were in the distal 1/3 pf the epiphysis. Six were anterior and 14 were anterior-inferior to the fibular tip. MRI findings: Sixteen of the 20 ankles (80%) had positive MRI findings (figure 1), and 4 had negative findings (figure 2). The ATFL attached directly to the fragment in 11 of the 16 MRI positive ankles. Clinical decision making: All athletes with negative MRI findings responded to non-operatively management. Ten of the 16 ankles with positive MRIs have had surgery. Eight had excision of the ossicle and two had internal fixation based on the size of the ossicle. Surgical findings confirmed attachment of the ATFL to the fragment (figure 3.) Six athletes with positive MRIs continue to be under observation. Conclusions The results support our hypothesis that MRI has predictive value in clinical decision-making for symptomatic athletes with a SO. When fluid-sensitive MRI sequences show high signal intensity between the ossicle and the fibular epiphysis, and when the ATFL attaches to the ossicle, the athlete has a poor prognosis for non-operative management. [Figure: see text][Figure: see text] References: Su AW, Larson AN. Pediatric ankle fractures: Concepts and treatment principles. Foot Ankle Clin. 2015;20(4):705-719. Pommering TL, Kluchurosky L, Hall SL. Ankle and foot injuries in pediatric and adult athletes. Prim Care 2005;32(1):133-161. Han SH, Choi WJ, Kim S, Kim S-J, Lee JW. Ossicles associate with chronic pain around the malleoli of the ankle. 2008;90-B:1049-1054. Gamble JG, Sugi M, Tileston KR, Chan CM, Livingston KS. The natural history of type VII all-epiphyseal fractures of the lateral malleolus. Orthop J Sports Med. 2019; 7(3) (suppl 1) DOI 10.1177/2325967119S00116. Pill SG, Hatch M, Linton JM, Davidson RS. JBJS 2013;95: e115(1-6). Han SH, Choi WJ, Kim S, Kim SJ, Lee JW. Ossicles associated with chronic pain around the malleoli of the ankle. J Bone Joint Surg Br. 2008;90(8):1049-1054. Danielsson LG. Avulsion fracture of the lateral malleolus in children. Injury 12:165-167
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Školoudík, Lukáš, Eva Šimáková, David Kalfeřt, and Viktor Chrobok. "Histological Changes of the Middle Ear Ossicles Harvested during Cholesteatoma Surgery." Acta Medica (Hradec Kralove, Czech Republic) 58, no. 4 (2015): 119–22. http://dx.doi.org/10.14712/18059694.2016.2.

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Background: In the cholesteatoma surgery ossicles can be replaced to reconstruct middle ear function. It is important that these ossicles are free of squamous epithelium, to prevent residual disease. This study focuses on the histological findings of the malleus and incus harvested during cholesteatoma surgery. Materials and Methods: Eighty middle ears ossicles were examined in vivo and histologically to consider the relationship of cholesteatoma to ossicles, grade of bone destruction and invasion of cholesteatoma to deeper layers of bone. Results: Serious ossicular destruction was observed more frequently in incus compared to malleus (p = 0.0065). Difference of ossicles destruction between children and adults was not significant (p = 0.3032). Deep invasion of cholesteatoma into the vascular spaces or inner core of the bone was not observed. Conclusions: Autograft ossicles from cholesteatomatous ears should not necessarily be rejected for reconstruction of the ossicular chain. Regarding the histological finding, the authors suggest mechanical cleaning of the ossicle surface to eliminate residual disease.
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Shin, Hyuk Soo, Dong Yeon Lee, and Doo Jae Lee. "Clinical Implication of Os subfibulare." Foot & Ankle Orthopaedics 2, no. 3 (September 1, 2017): 2473011417S0003. http://dx.doi.org/10.1177/2473011417s000374.

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Category: Ankle, Sports, Trauma Introduction/Purpose: Os subfibulare, defined as a separated ossicle of the distal fibular, has been linked to various clinical problems such as subfibulare pain and chronic lateral ankle instability. However, whether os subfibulare is congenital or traumatic remains unclear. The objectives of this study were: 1) to determine the incidence of os subfibulare development after ankle sprain in children and adolescents in a single primary care orthopedic clinic, and 2) to evaluate clinical implication of os subfibulare associated with ankle sprain in children and adolescents Methods: Among 896 pediatric patients (age ranging from 3 to 16 years) who visited a single primary care unit after sustaining ankle inversion injury, 627 patients who were followed up for over 2 weeks were included in this study. For each pediatric patient, physical examination and radiographic examination (anteroposterior, lateral, and mortise view of the bilateral ankle) were performed. The incidence of os subfibulare was evaluated based on initial radiographic examination. To analyze the incidence of new os subfibulare formation after ankle inversion injury, radiographs of 193 patients who were followed up for more than 6 months were evaluated according to the grade of injury. Results: At initial visit, 1% of examined ankles (13 from 1,254 ankles of 627 patients) showed well corticated ossicle not related to initial injuries. We cannot recognize the existence of accessory ossification center of the fibula in our study population. Overall incidence of os subfibulare at final follow up after ankle inversion injury was 23.9% (150/627). Os subfibulare at final follow up was correlated with initial injury grade (OR: 8.0, p = 0.001). In patients with initial avulsion fragment, 64.9% (61/94 cases) had residual ossicle at the final radiograph after being followed up for more than 6 months. As for the morphology of ossicle, 54 cases with wafer bone fragment at the time of initial injury showed oval or round shape ossicles at final radiograph. Conclusion: The incidence of os subfibulare at the initial radiograph was about 1%. The chance of ossicle formation after ankle inversion injury was substantially high in pediatric population. Based on the findings of our study, we carefully suggest that majority, if not all, of os subfibulare would be posttraumatic in pediatric period. Therefore, ankle inversion injury in children should be managed more actively to reduce the chance of posttraumatic os subfibulare formation.
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Brister, Eileen Y., Robert H. Withnell, Pavel Shevchenko, and Claus-Peter Richter. "Are suspensory ligaments important for middle ear reconstruction?" PLOS ONE 16, no. 8 (August 24, 2021): e0255821. http://dx.doi.org/10.1371/journal.pone.0255821.

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As the resolution of 3D printing techniques improves, the possibility of individualized, 3-ossicle constructions adds a new dimension to middle ear prostheses. In order to optimize these designs, it is essential to understand how the ossicles and ligaments work together to transmit sound, and thus how ligaments should be replicated in a middle ear reconstruction. The middle ear ligaments are thought to play a significant role in maintaining the position of the ossicles and constraining axis of rotation. Paradoxically, investigations of the role of ligaments to date have shown very little impact on middle ear sound transmission. We explored the role of the two attachments in the gerbil middle ear analogous to human ligaments, the posterior incudal ligament and the anterior mallear process, severing both attachments and measuring change in hearing sensitivity. The impact of severing the attachments on the position of the ossicular chain was visualized using synchrotron microtomography imaging of the middle ear. In contrast to previous studies, a threshold change on the order of 20 dB across a wide range of frequencies was found when both ligaments were severed. Concomitantly, a shift in position of the ossicles was observed from the x-ray imaging and 3D renderings of the ossicular chain. These findings contrast with previous studies, demonstrating that these ligaments play a significant role in the transmission of sound through the middle ear. It appears that both mallear and incudal ligaments must be severed in order to impair sound transmission. The results of this study have significance for middle ear reconstructive surgery and the design of 3D-printed three-ossicle biocompatible prostheses.
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Chang, Song Ho, Takumi Matsumoto, Masashi Naito, and Sakae Tanaka. "Stenosing Tenosynovitis of the Flexor Hallucis Longus Tendon Associated with the Plantar Capsular Accessory Ossicle at the Interphalangeal Joint of the Great Toe." Case Reports in Orthopedics 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/2146762.

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This report presents a case of stenosing tenosynovitis of the flexor hallucis longus tendon associated with the plantar capsular accessory ossicle at the interphalangeal joint of the great toe, which was confirmed by intraoperative observation and was successfully treated with surgical resection of the ossicle. As the plantar capsular accessory ossicle was not visible radiographically due to the lack of ossification, ultrasonography was helpful for diagnosing this disorder.
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Martonos, Cristian, Alexandru Gudea, Călin Lațiu, Milos Blagojevic, and Florin Stan. "Morphological and Morphometrical Aspects of the Auditory Ossicles in the European Badger (Meles Meles)." Veterinary Sciences 9, no. 9 (September 8, 2022): 483. http://dx.doi.org/10.3390/vetsci9090483.

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Given the scarce morphological data regarding the middle ear anatomy of this species, the paper attempts to describe the morphological and morphometrical data of the auditory ossicles in the badger. The study was performed using the standard morphological investigations and provides a complete morphological description of the ossicular assembly (malleus, incus and stapes) with some comparative features and attempts to provide a complete set of standardized metrical data for each ossicle. A more-detailed attempt to compare some functional aspects in the light of combined metrical ratios is also implied.
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35

Lambert, Philip. "Psolidium bidiscum, a new shallow-water psolid sea cucumber (Echinodermata: Holothuroidea) from the northeastern Pacific, previously misidentified as Psolidium bullatum Ohshima." Canadian Journal of Zoology 74, no. 1 (January 1, 1996): 20–31. http://dx.doi.org/10.1139/z96-004.

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A common west-coast psolid sea cucumber, formerly identified as Psolidium bullatum Ohshima, 1915, is described as a new species. Psolidium bidiscum n.sp. has two types of ventral ossicles, one type of dorsal cup, and 10 scales between the mouth and anus. Psolidium bullatum Ohshima, 1915 has one type of ventral ossicle, no dorsal cups, and 19 scales between the mouth and anus. Psolidium bidiscum is known from southeastern Alaska south to Monterey, California, between 0 and 200 m in depth. Psolidium bidiscum is compared with six other species of Psolidium from the eastern Pacific.
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YAMANA, YUSUKE, and HISANORI KOHTSUKA. "Dendrochirotid holothurians (Echinodermata: Holothuroidea: Dendrochirotida) including four new species, from off Misaki, Japan." Zootaxa 4455, no. 3 (August 3, 2018): 429. http://dx.doi.org/10.11646/zootaxa.4455.3.2.

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Four new dendrochirotid sea cucumbers, Neocucumis misakiensis sp. nov., Pseudocolochirus misakiensis sp. nov., Lipotrapeza purpurata sp. nov., and Pentamera misakiensis sp. nov., and three other known species, Amphicyclus japonicus Bell, 1884, Cucumaria tegulata Augustin, 1908, and Placothuria ohshimai Liao, 1997, are described from off Jyogashima Island, Misaki peninsula, south coast of Kanagawa Prefecture, Japan. In this study, Cucumaria tegulata Augustin, 1908, is referred to the genus Hemiocnus Mjobo & Thandar, 2016. Furthermore, a new phyllophorid genus Pseudoplacothuria is here erected to accommodate Placothuria ohshimai Liao, 1997. Although its external and internal body morphology and most of the ossicle morphology resemble those of Pentamera spp., it differs in possessing thick lens-shaped ossicles in the body wall, and also in possessing needle-shaped ossicles in the gonadal tubules.
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&NA;. "The Ossicle of Paaw." Otology & Neurotology 35, no. 9 (October 2014): 1668. http://dx.doi.org/10.1097/mao.0000000000000625.

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38

Graboyes, Evan M., Richard A. Chole, and Timothy E. Hullar. "The Ossicle of Paaw." Otology & Neurotology 32, no. 7 (September 2011): 1185–88. http://dx.doi.org/10.1097/mao.0b013e31822a28df.

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39

Loza, Cleopatra M., Oliver Reutimann, Marcelo R. Sánchez-Villagra, Alfredo A. Carlini, and Gabriel Aguirre-Fernández. "Evolutionary transformations of the malleus in pinnipeds, with emphasis on Southern Hemisphere taxa." Contributions to Zoology 87, no. 2 (July 18, 2018): 75–85. http://dx.doi.org/10.1163/18759866-08702002.

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The systematic value of the middle-ear ossicles, in particular the malleus, has been long recognized for diverse groups. We present systematic work on the characters of the middle-ear ossicles of pinnipeds, focusing on until now poorly studied Southern Hemisphere species. Mallei were extracted from 16 specimens of pinnipeds belonging to five austral and one boreal species of Phocidae and two austral species of Otariidae. Several characters used in this study have been described previously, and some were here modified. Three new characters are here defined and analysed. All characters were mapped onto the phylogeny. Our character analysis shows the transformations that have occurred in the evolution of middle ear ossicles in pinnipeds and identifies diagnostic features of many of its clades. Beyond the identification of specific changes within eachclade, our study of pinniped ossicle evolution documents the occurrence of anatomical convergences with other groups of mammals that live in an aquatic environment, as has occurred in other organ systems as well.
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SEKI, HIROYUKI. "Resonance measurement of auditory ossicle." AUDIOLOGY JAPAN 40, no. 5 (1997): 619–20. http://dx.doi.org/10.4295/audiology.40.619.

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41

Yoo, Jae Ho, Bo Kyu Yang, and Bo Kyeong Son. "Meniscal ossicle: A case report." Knee 14, no. 6 (December 2007): 493–96. http://dx.doi.org/10.1016/j.knee.2007.07.008.

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TAKAGI, Akira, Iwao HONJO, Akihiko FUJITA, Hajime NAKAMURA, and Juichi ITO. "Allogenic Auditory Ossicle in Tympanoplasty." Practica Oto-Rhino-Laryngologica 87, no. 2 (1994): 207–13. http://dx.doi.org/10.5631/jibirin.87.207.

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43

Widyatama, I. Ketut Hary, Edi Handoko, and Ahmad Dian Wahyudiono. "Hubungan kadar Interleukin-6 kolesteatoma dengan derajat kerusakan tulang pendengaran pasien otitis media supuratif kronis." Oto Rhino Laryngologica Indonesiana 44, no. 2 (April 7, 2015): 83. http://dx.doi.org/10.32637/orli.v44i2.89.

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Latar belakang: Kolesteatoma adalah lesi keratin non-neoplastik yang berhubungan dengan proliferasi sel epitel dengan karakteristik morfologi yang menyimpang. Otitis Media Supuratif Kronis (OMSK) yang disertai dengan adanya kolesteatoma dapat mengganggu keseimbangan antara pembentukan tulang dengan resorpsi tulang. Kolesteatoma dapat menghasilkan sitokin-sitokin seperti interleukin-6 (IL-6) yang berperan dalam proses destruksi tulang pendengaran. Tujuan: Mengetahui distribusi derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma, rerata kadar IL-6 pada kolesteatoma, dan adanya hubungan antara kadar IL-6 pada kolesteatoma dengan derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma. Metode: Penelitian ini melibatkan 6 pasien dengan OMSK dengan kolesteatoma yang dilakukan operasi mastoidektomi. Satu pasien menderita OMSK dengan kolesteatoma bilateral dan dilakukan operasi mastoidektomi pada kedua telinganya. Derajat kerusakan tulang pendengaran dinilai dengan menggunakan kriteria Saleh danMills, sedangkan kadar IL-6 pada kolesteatoma diukur dengan menggunakan instrumen ELISA. Hasil:Derajat kerusakan tulang pendengaran tertinggi yang ditemukan adalah derajat 3 (28,57%), sedangkan derajat kerusakan tulang pendengaran yang terbanyak adalah derajat 2 (42,86%). Kadar IL-6 pada kolesteatoma yang tertinggi adalah 2290 pg/mL, sedangkan rerata kadar IL-6 pada kolesteatoma adalah 1778,57±392,616 pg/mL. Kesimpulan: Kadar IL-6 pada kolesteatoma tidak berhubungan dengan derajat kerusakan tulang pendengaran pada pasien OMSK dengan kolesteatoma (p=0,885).Kata kunci: Kadar IL-6 kolesteatoma, derajat kerusakan tulang pendengaran, OMSK dengan koles-teatoma. ABSTRACTBackgrounds: Cholesteatoma is non neoplastic keratinized lesion related to epithelial cell proliferation with deviated morphologic characteristic. Chronic Suppurative Otitis Media (CSOM) with cholesteatoma may cause imbalance between bone formation and resorption. Cholesteatoma may produce cytokines such as interleukin-6 (IL-6) which has a role in ossicle destruction. Objectives: To evaluate the distribution of ossicle destruction degree in CSOM with cholesteatoma patients, mean of IL-6 level in cholesteatoma and the relationship between IL-6 level in cholesteatoma and ossicle destruction degree in CSOM with cholesteatoma patients. Methods: This study involved 6 CSOM with cholesteatoma patients who underwent mastoidectomy. One patient had bilateral CSOM with cholesteatoma and underwent mastoidectomy in both ears. Ossicle destruction degree was determined by using Saleh and Mills criterias whereas IL-6 level in cholesteatoma was measured by using ELISA kit. Results: The highest ossicle destruction degree was the third degree (28.57%), whereas the most common ossicle destruction degree was the second degree (42.86%). The highest IL-6 level in cholesteatoma was2290 pg/mL, whereas mean of IL-6 level in cholesteatoma was 1778.57 ± 392.616 pg/mL. Conclusions: IL-6 level in cholesteatoma didn’t have relationship with ossicle destruction degree in CSOM with cholesteatoma patients (p=0,885).Keywords: IL-6 level in cholesteatoma, ossicle destruction degree, CSOM with cholesteatoma.
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Mallo, M., H. Schrewe, J. F. Martin, E. N. Olson, and S. Ohnemus. "Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium." Development 127, no. 19 (October 1, 2000): 4127–36. http://dx.doi.org/10.1242/dev.127.19.4127.

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In terrestrial mammals, hearing starts with the perception of acoustic pressure by the tympanic membrane. Vibrations in this membrane are then transduced into the inner ear by the ossicle chain of the middle ear, composed of the malleus, incus and stapes. The proper connection of the ossicle chain with the tympanic membrane, provided by the insertion of the manubrium of the malleus into the eardrum, is essential for the functionality of the hearing apparatus. We describe here the mechanisms regulating the development of the manubrium and its integration into the tympanic membrane. We show that the external acoustic meatus (EAM), which eventually forms the outer epithelium of the tympanic membrane, plays an essential role in this developmental process. Histological and expression analyses indicate that the manubrium develops close to the EAM with a similar temporal sequence. In addition, when the middle ear ossicles are allowed to develop in vitro under conditions that do not support further EAM development, the manubrium develops only up to the stage of its induction at the time of explantation. Moreover, genetically or teratogenically derived alterations in the EAM also have an effect on manubrial development. Finally, we show that the EAM is the source of two quite opposite activities, one that induces chondrogenesis and another that represses it. The combination of these two activities results in the proper positioning of the manubrium.
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Schuring, Arnold G., and William H. Lippy. "The Ossicle-Cup Prosthesis: Five Years Later." Otolaryngology–Head and Neck Surgery 95, no. 2 (September 1986): 219–21. http://dx.doi.org/10.1177/019459988609500216.

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The osslcle-cup prosthesis is a semibiologic prosthesis that incorporates a synthetic portion into the remaining (or transplant) ossicle. This assembly is positioned on the stapes capitulum, with the synthetic cup forming a dynamic joint. During 1978, 114 patients underwent surgical procedures in which an ossicle cup prosthesis was used. After I year 84% of these patients were within 20 dB of their preoperative bone hearing levels. Patients with a concurrent mastoidectomy did worse than those who underwent only a tympanoossiculoplasty. Five years later, 74% of the successful cases were still within 20 dB of the preoperative hearing levels. Eighteen patients underwent a revision surgical procedure to regain hearing. The postoperative hearing results at 1 year were 50% within 20 dB. The causes of failure included further ossicle necrosis (28%), a laterally healed tympanic membrane (39%), and fixation of the prosthesis (33%). Extrusion of the prosthesis during the 5-year period was between 1% and 2%. Overall, the ossicle cup prosthesis has proved to be a stable assembly, easy to revise, and longlasting. Once successful, three of four cases will retain successful hearing for more than 5 years.
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Massin, Claude, Annie Mercier, and Jean-François Hamel. "Ossicle change in Holothuria scabra with a discussion of ossicle evolution within the Holothuriidae (Echinodermata)." Acta Zoologica 81, no. 1 (December 24, 2001): 77–91. http://dx.doi.org/10.1046/j.1463-6395.2000.00039.x.

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47

Feeney, Micheál S., Aiden T. Devitt, and Michael M. Stephens. "Duplication of the Medial Column Presenting as a Fixed Equinus Deformity: A Case Report." Foot & Ankle International 19, no. 2 (February 1998): 120–22. http://dx.doi.org/10.1177/107110079801900214.

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A case of accessory talus is described in which a large ossicle on the medial aspect of the talus had formed an articulation with the distal tibial epiphysis and had produced a fixed equinus deformity of the ankle. We propose that this ossicle, in association with a previously excised accessory toe at the level of the base of the first metatarsal, represents a partial duplication of the medial column of the foot.
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LI, YA-NAN, NING XIAO, LV-PING ZHANG, and HAIBIN ZHANG. "Benthodytes marianensis, a new species of abyssal elasipodid sea cucumbers (Elasipodida: Psychropotidae) from the Mariana Trench area." Zootaxa 4462, no. 3 (August 28, 2018): 443. http://dx.doi.org/10.11646/zootaxa.4462.3.10.

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Benthodytes marianensis sp. nov., is described from the Mariana Trench at the depth of 5567 m. This is the thirteenth species in Benthodytes Théel, 1882. The new species has a broad brim around the body, dark violet skin, 9 pairs of large dorsal papillae with other papillae of equal or smaller size situated elsewhere, forming two zigzag rows, and some minute papillae scattered around the anterior region. Body wall ossicles are rods, crosses with three or four arms and central apophyses, and crosses of an unusual type. Crosses with four arms and central bipartite, tripartite and tetrapartite apophyses and peculiar cross-shaped ossicles with high apophyses ending in two horizontal arms are present in the dorsum. Large rod-shaped ossicles with bipartite apophyses and crosses with three or four arms and rudimentary apophyses are present on the ventrum. B. marianensis is morphologically most similar to B. incerta, but it is distinguished from B. incerta by the number and arrangement of dorsal large papillae, the broad brim and details of ossicle morphology. The phylogenetic analyses based on (16S, COI) and nuclear genes (H3) all confirm the morphological identification.
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Tadaki, Tohru, Ryosuke Kamiyama, Hiro-Oki Okamura, and Iwao Ohtani. "Anomalies of the auditory organ in trisomy 18 syndrome: human temporal bone histopathological study." Journal of Laryngology & Otology 117, no. 7 (July 2003): 580–83. http://dx.doi.org/10.1258/002221503322113094.

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The purpose of this study was to define the histopathological changes in the temporal bone of a fetus with trisomy 18 syndrome, a stillborn due to perosplanchnia. Several anomalies were found including malformation of the auditory ossicles, residual mesenchyme in the middle ear, aberrant tensor tympani muscle, absence of stapedial tendon, aberrant lateral ampullary nerve and wide endolymphatic sinus. The incus body was deformed and separated from the long process by connective tissue and monocrural stapes was noted in the right ear. Three-dimensional reconstruction images provided a clear view of the auditory ossicle malformation. The abnormal findings in our case indicate that ear anomalies in this syndrome might be derived from the component around the first and second branchial arches.
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Kurashige, Toshinori. "Removal of Painful Os Paracuneiforme: A Case Report." Foot & Ankle Specialist 13, no. 3 (February 14, 2020): 236–41. http://dx.doi.org/10.1177/1938640020905414.

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Os paracuneiforme (OPC) is an extremely rare accessory bone located either medial to the medial cuneiform or to the naviculocuneiform joint. Although OPC often appears on the list of accessory ossicles, there are few reported cases regarding this bone. OPC can cause symptoms that require surgical intervention, but only 2 surgically treated cases have been published in the literature in English. Here, we report the case of a patient with painful OPC who was surgically treated. The patient showed no restriction in his daily living and recreational activities 6 months postoperatively. This is the first report showing not only preoperative and postoperative radiographs, but also preoperative CT images, photographs of intraoperative findings, and the resected ossicle. Level of Evidence: Level V
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