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Journal articles on the topic 'Osseointegration'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 September 2023

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1

Yi, Young-Ah, Young-Bum Park, Hyunmin Choi, Keun-Woo Lee, Sun-Jai Kim, Kwang-Mahn Kim, Seunghan Oh, and June-Sung Shim. "The Evaluation of Osseointegration of Dental Implant Surface with Different Size of TiO2Nanotube in Rats." Journal of Nanomaterials 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/581713.

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With the development of nanotechnology, many researches have shown that nanometer-scaled materials especially TiO2nanotube have a positive effect on cellular behavior and surface characteristics of implant, which are considered to be crucial factors in osseointegration. However, it has not yet been verified which nanotube size is effective in osseointegrationin vivo. The aim of this study was to evaluate the effect of implant surface-treated with different size of TiO2nanotubes on osseointegration in rat femur. The customized implants (threaded and nonthreaded type), surface-treated with different diameter of TiO2nanotubes (30 nm, 50 nm, 70 nm, and 100 nm nanotube), were placed on both sides of the femur of 50 male Sprague-Dawley rats (6 weeks old). Rats were sacrificed at 2 and 6 weeks following surgery; then the specimens were collected by perfusion fixation and the osseointegration of implants was evaluated by radiographic and histologic analyses and removal torque value test. The mean of bone area (%) and the mean of removal torque were different in each group, indicating that the difference in TiO2nanotube size may influence new bone formation and osseointegration in rats.

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2

Dhinakarsamy, V., and RaghavendraS Jayesh. "Osseointegration." Journal of Pharmacy and Bioallied Sciences 7, no. 5 (2015): 228. http://dx.doi.org/10.4103/0975-7406.155917.

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3

Reddy, K. Vinathi. "Osseointegration." International Dental & Medical Journal of Advanced Research - VOLUME 2015 1, no. 1 (2015): 1–7. http://dx.doi.org/10.15713/ins.idmjar.23.

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4

Siegel, Michael A. "Osseointegration." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 88, no. 2 (August 1999): 113. http://dx.doi.org/10.1016/s1079-2104(99)70101-0.

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5

Trindade, Ricardo, Tomas Albrektsson, Silvia Galli, Zdenka Prgomet, Pentti Tengvall, and Ann Wennerberg. "Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia." Journal of Clinical Medicine 8, no. 6 (June 7, 2019): 814. http://dx.doi.org/10.3390/jcm8060814.

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Osseointegration is likely the result of an immunologically driven bone reaction to materials such as titanium. Osseointegration has resulted in the clinical possibility to anchor oral implants in jaw bone tissue. However, the mechanisms behind bony anchorage are not fully understood and complications over a longer period of time have been reported. The current study aims at exploring possible differences between copper (Cu) and polyetheretherketone (PEEK) materials that do not osseointegrate, with osseointegrating cp titanium as control. The implants were placed in rabbit tibia and selected immune markers were evaluated at 10 and 28 days of follow-up. Cu and PEEK demonstrated at both time points a higher immune activation than cp titanium. Cu demonstrated distance osteogenesis due to a maintained proinflammatory environment over time, and PEEK failed to osseointegrate due to an immunologically defined preferential adipose tissue formation on its surface. The here presented results suggest the description of two different mechanisms for failed osseointegration, both of which are correlated to the immune system.

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6

Kopp, Clifford D. "Branemark Osseointegration." Dental Clinics of North America 33, no. 4 (October 1989): 701–31. http://dx.doi.org/10.1016/s0011-8532(22)03120-2.

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7

Zaid, Musa B., Richard J. OʼDonnell, Benjamin K. Potter, and Jonathan A. Forsberg. "Orthopaedic Osseointegration." Journal of the American Academy of Orthopaedic Surgeons 27, no. 22 (November 2019): e977-e985. http://dx.doi.org/10.5435/jaaos-d-19-00016.

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8

Tamimi, F., and X. Wu. "Osseointegration Pharmacology." JDR Clinical & Translational Research 2, no. 3 (March 24, 2017): 211–13. http://dx.doi.org/10.1177/2380084417701897.

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The process of osseointegration around dental implants is similar to the biological events occurring during bone repair and fracture healing. Therefore, bone metabolic activity plays a crucial role on the success of osseointegration, and dysregulation of bone metabolism can have a negative impact on bone healing and implant osseointegration. Accordingly, it could be hypothesized that drugs interfering with healing and bone metabolism could affect osseointegration and implant survival. Looking into the relationship between pharmacology, osseointegration, and dental implants, drugs can open the door for new pharmacological innovations to improve implant success and avoid unnecessary complications, and it is also of special interest because most implant patients are elder adults who are often polymedicated. In this commentary, we discuss the discoveries made by us as well as by other researchers regarding the effect of several drugs on bone, osseointegration, and implant survival. Of particular interest is the growing evidence showing that commonly used drugs such as nonsteroidal anti-inflammatories, serotonin reuptake inhibitors, and proton pump inhibitors could lead to implant failure.

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9

Granström, G. "Craniofacial osseointegration." Oral Diseases 13, no. 3 (May 2007): 261–69. http://dx.doi.org/10.1111/j.1601-0825.2007.01365.x.

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10

Sperber, G. H. "Craniofacial osseointegration." Journal of Oral and Maxillofacial Surgery 53, no. 2 (February 1995): 226. http://dx.doi.org/10.1016/0278-2391(95)90427-1.

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11

&NA;. "Craniofacial Osseointegration." Journal of Craniofacial Surgery 8, no. 4 (July 1997): 246–51. http://dx.doi.org/10.1097/00001665-199707000-00003.

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12

Vaidya, Prutha, Swapna Mahale, Sunila Kale, and Agraja Patil. "Osseointegration- A Review." IOSR Journal of Dental and Medical Sciences 16, no. 01 (January 2017): 45–48. http://dx.doi.org/10.9790/0853-1601014548.

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13

Hoellwarth, Jason Shih, Kevin Tetsworth, S. Robert Rozbruch, M. Brianne Handal, Adam Coughlan, and Munjed Al Muderis. "Osseointegration for Amputees." JBJS Reviews 8, no. 3 (March 2020): e0043. http://dx.doi.org/10.2106/jbjs.rvw.19.00043.

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14

Schenk, Robert K., and Daniel Buser. "Osseointegration: a reality." Periodontology 2000 17, no. 1 (June 1998): 22–35. http://dx.doi.org/10.1111/j.1600-0757.1998.tb00120.x.

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15

Lee, Jennifer Wing Yee, and Manohar Lal Bance. "Physiology of Osseointegration." Otolaryngologic Clinics of North America 52, no. 2 (April 2019): 231–42. http://dx.doi.org/10.1016/j.otc.2018.11.004.

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16

WATTS, T. "Osseointegration is latin." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 89, no. 5 (May 2000): 532. http://dx.doi.org/10.1067/moe.2000.106694.

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17

Parithimarkalaignan, S., and T. V. Padmanabhan. "Osseointegration: An Update." Journal of Indian Prosthodontic Society 13, no. 1 (January 11, 2013): 2–6. http://dx.doi.org/10.1007/s13191-013-0252-z.

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18

Schultz, Richard Carlton. "Advanced Osseointegration Surgery." Annals of Plastic Surgery 30, no. 4 (April 1993): 383. http://dx.doi.org/10.1097/00000637-199304000-00022.

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19

Ciortea, Claudiu, Mariana Cărămidă, and Ioan Sîrbu. "Methods used to assess the osseointegration of dental implants." Romanian Journal of Stomatology 61, no. 3 (September 30, 2015): 243–49. http://dx.doi.org/10.37897/rjs.2015.3.6.

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The stability of dental implants is a prerequisite for osseointegration. Osseointegration is the process that involves the formation of bone around the dental implant, resulting in increased stability and its integration in the organism. Therefore, successful osseointegration contributes to a functionally optimal treatment. There is a need for a clinical method capable of measurement of bone quality at the time and following implant placement, to measure the degree of osseointegration and the ability of the implants to distribute loads to the surrounding bone. Research to date focuses on finding an ideal method to assess the osseointegration of dental implants in order to improve and broaden the clinical indications of dental implant systems. This paper aims to supply information about current methods used to assess the osseointegration of dental implants. In this regard, a literature review was conducted. Full-text scientific articles relevant to the chosen topic, written in English or whose text could be accessed in English were included.

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20

Sun, Ruoyue, Yaru Yang, Yanshu Ding, Jingwen Zhuang, Jingyuan Cui, and Long Bai. "Nervous System-Driven Osseointegration." International Journal of Molecular Sciences 23, no. 16 (August 10, 2022): 8893. http://dx.doi.org/10.3390/ijms23168893.

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Implants are essential therapeutic tools for treating bone fractures and joint replacements. Despite the in-depth study of osseointegration for more than fifty years, poor osseointegration caused by aseptic loosening remains one of the leading causes of late implant failures. Osseointegration is a highly sophisticated and spatiotemporal process in vivo involving the immune response, angiogenesis, and osteogenesis. It has been unraveled that the nervous system plays a pivotal role in skeletal health via manipulating neurotrophins, neuropeptides, and nerve cells. Herein, the research related to nervous system-driven osseointegration was systematically analyzed and reviewed, aiming to demonstrate the prominent role of neuromodulation in osseointegration. Additionally, it is indicated that the implant design considering the role of neuromodulation might be a promising way to prevent aseptic loosening.

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21

Nandal, Dr Shikha, Dr Pankaj Ghalaut, Dr Himanshu Shekhawat, and Dr Priya Nagar. "Osseointegration in Dental Implants: A Literature Review." Indian Journal of Applied Research 4, no. 7 (October 1, 2011): 411–13. http://dx.doi.org/10.15373/2249555x/july2014/129.

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22

Pandey, Chandrashekhar, Dinesh Rokaya, and Bishwa Prakash Bhattarai. "Contemporary Concepts in Osseointegration of Dental Implants: A Review." BioMed Research International 2022 (June 14, 2022): 1–11. http://dx.doi.org/10.1155/2022/6170452.

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In a society highly conscious of esthetics, prosthetic rehabilitation of lost teeth with tissue-integrated implants has gained wide acceptance and demand by patients and clinicians. The backbone of these tissue-integrated implants is the biotechnical process of osseointegration. Although the concept has been introduced and discussed for ages, the deepening knowledge about its cellular and molecular mechanisms has led the researchers to borrow further into the factors influencing the process of osseointegration. This has aided in the hastening and improving the process of osseointegration by exploiting several, even the minutest, details and events taking place in this natural process. Recently, due to the high esthetic expectations of the patients, the implants are being loaded immediately, which demands a high degree of implant stability. Implant stability, especially secondary stability, largely depends on bone formation and integration of implants to the osseous tissues. Various factors that influence the rate and success of osseointegration can either be categorized as those related to implant characteristics like the physical and chemical macro- and microdesign of implants or the bone characteristics like the amount and quality of bone and the local and systemic host conditions, or the time or protocol followed for the functional loading of the dental implant. To address the shortcomings in osseointegration due to any of the factors, it is mandatory that continuous and reliable monitoring of the status of osseointegration is done. This review attempts to encompass the mechanisms, factors affecting, and methods to assess osseointegration, followed by a discussion on the recent advances and future perspectives in dental implantology to enhance the process of osseointegration. The review was aimed at igniting the inquisitive minds to usher further the development of technology that enhances osseointegration.

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23

Perez, Edith, Liliana Salinas, Roman Mendoza, Maria Eugenia Guerrero, Jose Oliva, and Frank Mayta-Tovalino. "Osseointegration of dental implants in patients with congenital and degenerative bone disorders: A literature review." Journal of International Society of Preventive and Community Dentistry 13, no. 3 (2023): 167–72. http://dx.doi.org/10.4103/jispcd.jispcd_51_22.

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Abstract Aims and Objectives: The aim of this study was to describe the mechanism of dental implants osseointegration in patients with congenital and degenerative genetic bone disorders. Materials and Methods: A PubMed and Scopus documents search was carried out between November 2021 in the, using words such as “osseointegration,” “degenerative disease,” “congenital disease,” and “dental implants.” Results: The thirteen articles selected dealt with dental implants osseointegration in patients with congenital and degenerative bone disorders. The influence and repercussion of these diseases on the bone system, as well as the osseointegration process were described from healing to bone remodeling. In addition, certain articles described some considerations to improve the osseointegration process in patients suffering from these types of conditions. Conclusions: Within the limitations of this literature review we can conclude that osseointegration in patients with ectodermal dysplasia and osteoporosis could be achieved. However, the planning process for dental implant placement in these patients should be more meticulous and individualized considering the degree of tissue involvement as well as the patient’s age and skeletal development compared to systemically healthy patients.

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24

Wang, Ya-Nan, Tingting Jia, Jiajia Zhang, Jing Lan, Dongjiao Zhang, and Xin Xu. "PTPN2 improves implant osseointegration in T2DM via inducing the dephosphorylation of ERK." Experimental Biology and Medicine 244, no. 16 (October 15, 2019): 1493–503. http://dx.doi.org/10.1177/1535370219883419.

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Type 2 diabetes mellitus (T2DM) is considered to compromise implant osseointegration. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) regulates glucose metabolism, systemic inflammation, and bone regeneration. This study aimed to investigate the role of PTPN2 in implant osseointegration in T2DM and explore the potential mechanisms. Streptozotocin-induced diabetic rats received implant surgery, with or without local overexpression of PTPN2 for three months, and implant osseointegration was examined by histological evaluation, micro-CT analysis, pull-out test, and scanning electron microscope. Rat bone marrow stem cells (RBMSCs) were isolated and exposed to high glucose, and osteogenic differentiation was evaluated by alizarin red staining, ALP assay, and Western blot analysis. Overexpression of PTPN2 could improve impaired implant osseointegration in T2DM rats and promote osteogenic differentiation of RBMSCs in high glucose. In addition, p-ERK level in RBMSCs was increased in high glucose and decreased after PTPN2 overexpression. These results suggest that PTPN2 promotes implant osseointegration in T2DM rats and enhances osteogenesis of RBMSCs in high glucose medium via inducing the dephosphorylation of ERK. PTPN2 may be a novel target for the therapy of impaired implant osseointegration in T2DM patients. Impact statement Using both in vivo and in vitro approaches, we made important findings that PTPN2 promoted implant osseointegration in T2DM rats and enhanced osteogenesis of RBMSCs in high glucose medium. The positive effects of PTPN2 on osteogenesis are related to the dephosphorylation of ERK and the inhibition of MAPK/ERK pathway. PTPN2 may be a novel target for the therapy of impaired implant osseointegration in T2DM patients.

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25

Roatesi, Iulia, and Simona Roatesi. "Modeling of Dental Implant Osseointegration Progress by Three-Dimensional Finite Element Method." Applied Sciences 10, no. 16 (August 11, 2020): 5561. http://dx.doi.org/10.3390/app10165561.

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As osseointegration is a time-dependent process, biomechanical assessment is thought to determine whether a fibrous encapsulation or a bone covering will develop around an implant, according to the stress in the implant and surrounding bone. This study proposes a model for stress evaluation by finite element method (FEM) during the osseointegration progress, the main factor implied in implant success or failure. The loadings due to masticatory forces generate stress concentration and consequently, an adequate risk concerning the implant stability should be assessed. An accurate FEM model is used to calculate the stress and displacement in the whole implant–bone system during the osseointegration progress. This process is simulated by taking into account the gradual increase in the damaged biomechanical properties of the cortical bone. The results reveal that as the implant osseointegration occurs gradually, the bone stiffness from the peri-implant area increases gradually, such that in the end (healing) we observed that the cortical bone begins to take over the bending loading. In addition, the displacements decrease as the osseointegration gradually occurs and the cortical bone stress reaches higher values, which are placed in the mandibular ridge. The FEM is suitable to model the osseointegration progress, offering valuable information concerning the stress concentration zones in the implant–bone system and consequently, the risk evaluation, both for pre- and post-osseointegration.

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26

Mehboob, Hassan, Abdelhak Ouldyerou, and Muhammad Farzik Ijaz. "Biomechanical Investigation of Patient-Specific Porous Dental Implants: A Finite Element Study." Applied Sciences 13, no. 12 (June 13, 2023): 7097. http://dx.doi.org/10.3390/app13127097.

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The design of the implant and osseointegration play an important role in the long-term stability of implants. This study aims to investigate the impact of porous implants on full and partial osseointegration in varying bone qualities. Finite element models of porous implants were modeled and assembled with normal and weak bones considering full and partial osseointegration. These assemblies were simulated under an occlusal load of 200 N when the outer surfaces of bones were fixed in all directions. The results showed that in the case of full osseointegration, the stresses in surrounding bones were increased with decreasing implant stiffness, while decreased in partial osseointegration. Moreover, the maximum octahedral shear strain in the weak bone exceeded 3000 µε in all the cases but decreased (from 7256 to 3632 µε) with decreasing implant stiffness. According to the mechanostat hypothesis, using porous implants in normal bone may enhance bone density in full osseointegration, while susceptivity of bone damage may reduce in weak bones using porous implants. Thus, careful selection of implant material and design based on the patient’s specific bone quality is crucial for successful outcomes.

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27

Choe, H., BS Hausman, KM Hujer, O. Akkus, PN Rather, Z. Lee, RA Bonomo, and EM Greenfield. "Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration." European Cells and Materials 43 (June 9, 2022): 267–76. http://dx.doi.org/10.22203/ecm.v043a18.

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Implant infection impairs osseointegration of orthopaedic implants by inducing inflammation. Acinetobacter spp. are increasingly prevalent multi-drug resistant bacteria that can cause osteomyelitis. Acinetobacter spp. can also cause inflammation and thereby inhibit osseointegration in mice. The purpose of the present study was to investigate the role of quorum sensing in this context. Therefore, wild-type bacteria were compared with an isogenic abaI mutant defective in quorum sensing in a murine osseointegration model. The abaI quorum- sensing mutant affected significantly less osseointegration and interleukin (IL) 1β levels, without detectably altering other pro-inflammatory cytokines. Wild-type bacteria had fewer effects on IL1 receptor (IL1R)−/− mice. These results indicated that quorum sensing in Acinetobacter spp. contributed to IL1β induction and the resultant inhibition of osseointegration in mice. Moreover, targeting the Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections.

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28

Pătrașcu, Ion, and Bogdan Mihai Gălbinașu. "Considerations regarding the osseointegration of endosseous dental implants." Romanian Journal of Stomatology 67, no. 1 (March 31, 2021): 48–52. http://dx.doi.org/10.37897/rjs.2021.1.8.

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Implant osseointegration has not been accepted over time, considering that in fact the implant integration is performed only in the soft tissue of the host. For this reason, the implant has never been sufficiently integrated into the host tissue immediately after insertion. Experiments performed in Branemark laboratories in the early 1960s, with a new type of implant, which required a direct anchorage to bone tissue for clinical function, this anchorage was called osseointegration. It has been shown that it is possible to achieve direct osseointegration if the Branemark method is considered, which was published a few years later in the first clinical report. The authors of this article come up with new contributions that validate the implant osseointegration process. Inside this article we present our methodology for evaluating the osseointegration of endosseous implants: ESEM (environmental scanning electron microscope) studies of the implant-bone tissue interface.

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29

Ismail, John Y. H., and Hussein S. Zaki. "Osseointegration in Maxillofacial Prosthetics." Dental Clinics of North America 34, no. 2 (April 1990): 327–41. http://dx.doi.org/10.1016/s0011-8532(22)01150-8.

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30

Hoellwarth, Jason Shih, Kevin Tetsworth, Muhammad Adeel Akhtar, and Munjed Al Muderis. "Transcutaneous osseointegration for amputees." Bone & Joint Research 10, no. 10 (October 1, 2021): 690–92. http://dx.doi.org/10.1302/2046-3758.1010.bjr-2021-0235.r2.

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31

López-Valverde, Nansi, Javier Flores-Fraile, and Antonio López-Valverde. "The Unknown Process Osseointegration." Biology 9, no. 7 (July 16, 2020): 168. http://dx.doi.org/10.3390/biology9070168.

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Although it was already described more than fifty years ago, there is yet no in-depth knowledge regarding the process of osseointegration as far as its mechanism of action is concerned. It could be one of the body’s ways of reacting to a foreign body, where the individual’s immune response capacity is involved. It is known that the nervous system has an impact on bone health and that the role of the autonomic nervous system in bone remodeling is an attractive field for current research. In the future, immuno/neuromodulatory techniques will open new and exciting lines of research.

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32

Carlsson, Lars, Tord Röstlund, Björn Albrektsson, Tomas Albrektsson, and Per-Ingvar Brånemark. "Osseointegration of titanium implants." Acta Orthopaedica Scandinavica 57, no. 4 (January 1986): 285–89. http://dx.doi.org/10.3109/17453678608994393.

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33

Van Steenberghe, Daniel. "From Osseointegration to Osseoperception." Journal of Dental Research 79, no. 11 (November 2000): 1833–37. http://dx.doi.org/10.1177/00220345000790110301.

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34

Nishimura, I. "Genetic Networks in Osseointegration." Journal of Dental Research 92, no. 12_suppl (October 24, 2013): 109S—118S. http://dx.doi.org/10.1177/0022034513504928.

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35

Quilligan, G. "Osseointegration and dental implants." British Dental Journal 208, no. 1 (January 2010): 41–42. http://dx.doi.org/10.1038/sj.bdj.2010.45.

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36

Eckert, Steven. "Editorial: Osseointegration: Promise Fulfilled?" International Journal of Oral & Maxillofacial Implants 34, no. 3 (May 2019): 557–58. http://dx.doi.org/10.11607/jomi.2019.3.e.

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37

Aschoff, Horst-Heinrich. "Transkutane Osseointegration (Teil 1)." Der Unfallchirurg 120, no. 4 (March 29, 2017): 276–77. http://dx.doi.org/10.1007/s00113-017-0324-3.

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Aschoff, Horst-Heinrich. "Transkutane Osseointegration (Teil 2)." Der Unfallchirurg 120, no. 5 (May 2017): 366. http://dx.doi.org/10.1007/s00113-017-0325-2.

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Aschoff, Horst-Heinrich. "Transkutane Osseointegration nach Gliedmaßenamputation." Der Unfallchirurg 120, no. 4 (February 24, 2017): 278–84. http://dx.doi.org/10.1007/s00113-017-0329-y.

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40

Jagger, R. C. "Osseointegration in oral rehabilitation." Journal of Dentistry 22, no. 6 (December 1994): 375. http://dx.doi.org/10.1016/0300-5712(94)90092-2.

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41

Richardson, David W. "Osseointegration and occlusal rehabilitation." Journal of Prosthetic Dentistry 63, no. 2 (February 1990): 247. http://dx.doi.org/10.1016/0022-3913(90)90115-s.

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42

Vitkov, Ljubomir, Dominik Hartl, and Matthias Hannig. "Is osseointegration inflammation-triggered?" Medical Hypotheses 93 (August 2016): 1–4. http://dx.doi.org/10.1016/j.mehy.2016.05.004.

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43

Piarulli, G., A. Rossi, and G. Zatti. "Osseointegration in the elderly." Aging Clinical and Experimental Research 25, S1 (September 18, 2013): 59–60. http://dx.doi.org/10.1007/s40520-013-0103-0.

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44

Panda, Sangram. "Osseointegration: A Comprehensive Overview." Indian Journal of Public Health Research & Development 10, no. 11 (2019): 280. http://dx.doi.org/10.5958/0976-5506.2019.03474.0.

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45

GA, Zarb, and A. Schmitt. "Osseointegration for elderly patients." Implant Dentistry 4, no. 3 (September 1995): 206–10. http://dx.doi.org/10.1097/00008505-199509000-00023.

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46

Terheyden, Hendrik, Niklaus P. Lang, Susanne Bierbaum, and Bernd Stadlinger. "Osseointegration - communication of cells." Clinical Oral Implants Research 23, no. 10 (November 10, 2011): 1127–35. http://dx.doi.org/10.1111/j.1600-0501.2011.02327.x.

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47

Wang, Ya‐Nan, Tingting Jia, and Dongjiao Zhang. "Hyperlipidemia Impairs Implant Osseointegration." Clinical Oral Implants Research 30, S19 (September 2019): 137. http://dx.doi.org/10.1111/clr.95_13509.

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48

T., Albrektsson, and Johansson C. "Osteoinduction, osteoconduction and osseointegration." European Spine Journal 10 (October 1, 2001): S96—S101. http://dx.doi.org/10.1007/s005860100282.

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49

Pandey, Bashu Raj, Hemant Kumar Halwai, Khushbu Adhikari, and Amresh Thakur. "Evaluation of the Effect of Complete and Partial Osseointegration in Stress Development at Bone-Implant Interface: A 3D Finite Element Study." Orthodontic Journal of Nepal 6, no. 2 (December 31, 2016): 24–27. http://dx.doi.org/10.3126/ojn.v6i2.17416.

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Introduction: Mini-implant has been in use as temporary anchorage device in orthodontics. Various factors like length, type of osseointegration, magnitude and direction of force, insertion angle of the mini-implant affect the stress development at the bone and implant interface. Development of undesirable stress at the bone-implant interface can lead to bone defect and failure of the implant. Various opinions regarding the need of osseointegration have been reported.Objective: To study the effect of complete and partial osseointegration on Von Mises stress distribution at the bone-implant interface.Materials & Method: Finite element model of 9mm × 1.5mm mini-implant and bone segment of 1.5mm were constructed to simulate the biomechanical response of the bone to the mini- implant by using CATIA V5-6R 2013 software. Stress developed on implant and bone were analyzed by using ANSYS: 13 2013 version software for both complete and partial level of osseointegration.Result: Maximum Von Mises stress in complete osseointegration was 14.49 Mpa in cortical bone, 0.551 Mpa in cancellous bone and 50.76 Mpa in implant. In partial osseointegration, it was 18.68 Mpa in cortical bone, 1.23 Mpa in cancellous bone and 66.80 Mpa in mini-implant.Conclusion: In partial osseointegration, stress developed was higher but well below the yield strength of respected continuum. So the partial osseointegration is a good compromise between the necessity of reducing mobility of implant and the necessity for easier screw removal. Key words: cancellous bone, cortical bone, Finite element analysis, mini-implant, Von Mises stress

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Lu, Shouxun, Benjamin Steven Vien, Matthias Russ, Mark Fitzgerald, and Wing Kong Chiu. "Monitoring Osseointegration Process Using Vibration Analysis." Sensors 22, no. 18 (September 6, 2022): 6727. http://dx.doi.org/10.3390/s22186727.

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Osseointegration implant has attracted significant attention as an alternative treatment for transfemoral amputees. It has been shown to improve patients’ sitting and walking comfort and control of the artificial limb, compared to the conventional socket device. However, the patients treated with osseointegration implants require a long rehabilitation period to establish sufficient femur–implant connection, allowing the full body weight on the prosthesis stem. Hence, a robust assessment method on the osseointegration process is essential to shorten the rehabilitation period and identify the degree of osseointegration prior to the connection of an artificial limb. This paper investigates the capability of a vibration-related index (E-index) on detecting the degree of simulated osseointegration process with three lengths of the residual femur (152, 190 and 228 mm). The adhesive epoxy with a setting time of 5 min was applied at the femur–implant interface to represent the stiffness change during the osseointegration process. The cross-spectrum and colormap of the normalised magnitude demonstrated significant changes during the cure time, showing that application of these plots could improve the accuracy of the currently available diagnostic techniques. Furthermore, the E-index exhibited a clear trend with a noticeable average increase of 53% against the cure time for all three residual length conditions. These findings highlight that the E-index can be employed as a quantitative justification to assess the degree of osseointegration process without selecting and tracing the resonant frequency based on the geometry of the residual femur.

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