Relevant bibliographies by topics / Osseointegration

Academic literature on the topic 'Osseointegration'

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Published: 4 June 2021
Last updated: 7 September 2023

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Journal articles on the topic "Osseointegration"

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Yi, Young-Ah, Young-Bum Park, Hyunmin Choi, Keun-Woo Lee, Sun-Jai Kim, Kwang-Mahn Kim, Seunghan Oh, and June-Sung Shim. "The Evaluation of Osseointegration of Dental Implant Surface with Different Size of TiO2Nanotube in Rats." Journal of Nanomaterials 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/581713.

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With the development of nanotechnology, many researches have shown that nanometer-scaled materials especially TiO2nanotube have a positive effect on cellular behavior and surface characteristics of implant, which are considered to be crucial factors in osseointegration. However, it has not yet been verified which nanotube size is effective in osseointegrationin vivo. The aim of this study was to evaluate the effect of implant surface-treated with different size of TiO2nanotubes on osseointegration in rat femur. The customized implants (threaded and nonthreaded type), surface-treated with different diameter of TiO2nanotubes (30 nm, 50 nm, 70 nm, and 100 nm nanotube), were placed on both sides of the femur of 50 male Sprague-Dawley rats (6 weeks old). Rats were sacrificed at 2 and 6 weeks following surgery; then the specimens were collected by perfusion fixation and the osseointegration of implants was evaluated by radiographic and histologic analyses and removal torque value test. The mean of bone area (%) and the mean of removal torque were different in each group, indicating that the difference in TiO2nanotube size may influence new bone formation and osseointegration in rats.
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Dhinakarsamy, V., and RaghavendraS Jayesh. "Osseointegration." Journal of Pharmacy and Bioallied Sciences 7, no. 5 (2015): 228. http://dx.doi.org/10.4103/0975-7406.155917.

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Reddy, K. Vinathi. "Osseointegration." International Dental & Medical Journal of Advanced Research - VOLUME 2015 1, no. 1 (2015): 1–7. http://dx.doi.org/10.15713/ins.idmjar.23.

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Siegel, Michael A. "Osseointegration." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 88, no. 2 (August 1999): 113. http://dx.doi.org/10.1016/s1079-2104(99)70101-0.

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Trindade, Ricardo, Tomas Albrektsson, Silvia Galli, Zdenka Prgomet, Pentti Tengvall, and Ann Wennerberg. "Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia." Journal of Clinical Medicine 8, no. 6 (June 7, 2019): 814. http://dx.doi.org/10.3390/jcm8060814.

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Osseointegration is likely the result of an immunologically driven bone reaction to materials such as titanium. Osseointegration has resulted in the clinical possibility to anchor oral implants in jaw bone tissue. However, the mechanisms behind bony anchorage are not fully understood and complications over a longer period of time have been reported. The current study aims at exploring possible differences between copper (Cu) and polyetheretherketone (PEEK) materials that do not osseointegrate, with osseointegrating cp titanium as control. The implants were placed in rabbit tibia and selected immune markers were evaluated at 10 and 28 days of follow-up. Cu and PEEK demonstrated at both time points a higher immune activation than cp titanium. Cu demonstrated distance osteogenesis due to a maintained proinflammatory environment over time, and PEEK failed to osseointegrate due to an immunologically defined preferential adipose tissue formation on its surface. The here presented results suggest the description of two different mechanisms for failed osseointegration, both of which are correlated to the immune system.
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Kopp, Clifford D. "Branemark Osseointegration." Dental Clinics of North America 33, no. 4 (October 1989): 701–31. http://dx.doi.org/10.1016/s0011-8532(22)03120-2.

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Zaid, Musa B., Richard J. OʼDonnell, Benjamin K. Potter, and Jonathan A. Forsberg. "Orthopaedic Osseointegration." Journal of the American Academy of Orthopaedic Surgeons 27, no. 22 (November 2019): e977-e985. http://dx.doi.org/10.5435/jaaos-d-19-00016.

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Tamimi, F., and X. Wu. "Osseointegration Pharmacology." JDR Clinical & Translational Research 2, no. 3 (March 24, 2017): 211–13. http://dx.doi.org/10.1177/2380084417701897.

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The process of osseointegration around dental implants is similar to the biological events occurring during bone repair and fracture healing. Therefore, bone metabolic activity plays a crucial role on the success of osseointegration, and dysregulation of bone metabolism can have a negative impact on bone healing and implant osseointegration. Accordingly, it could be hypothesized that drugs interfering with healing and bone metabolism could affect osseointegration and implant survival. Looking into the relationship between pharmacology, osseointegration, and dental implants, drugs can open the door for new pharmacological innovations to improve implant success and avoid unnecessary complications, and it is also of special interest because most implant patients are elder adults who are often polymedicated. In this commentary, we discuss the discoveries made by us as well as by other researchers regarding the effect of several drugs on bone, osseointegration, and implant survival. Of particular interest is the growing evidence showing that commonly used drugs such as nonsteroidal anti-inflammatories, serotonin reuptake inhibitors, and proton pump inhibitors could lead to implant failure.
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Granström, G. "Craniofacial osseointegration." Oral Diseases 13, no. 3 (May 2007): 261–69. http://dx.doi.org/10.1111/j.1601-0825.2007.01365.x.

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Sperber, G. H. "Craniofacial osseointegration." Journal of Oral and Maxillofacial Surgery 53, no. 2 (February 1995): 226. http://dx.doi.org/10.1016/0278-2391(95)90427-1.

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Dissertations / Theses on the topic "Osseointegration"

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Kanter, Britta. "Osseointegration kalthaertender Knochenzemente im Schafmodell." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-174590.

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Da es bisher noch kein Knochenersatzmaterial gibt, das den komplexen Eigenschaften des Knochengewebes entspricht, wird intensiv an der Entwicklung neuer Materialien geforscht. In der vorgestellten Studie wurden ein Calciumphosphat- und ein Magnesiumphosphat-Zement (Bruschit bzw. Struvit) in einem unbelasteten und einem teilbelasteten Knochendefekt kritischer Größe im Schafmodell untersucht. Von jeder Zementformulierung kamen zwei unterschiedliche Pulver-Flüssigkeits-Verhältnisse (2,0 und 3,0), welche zu unterschiedlichen Porositäten der abgebundenen Zemente führten, zum Einsatz. Die Implantationszeiträume betrugen 4, 7 und 10 Monate. Als Kontrolle diente bei der 10-Monats-Gruppe ein CDHA-Zement (Ca9(PO4)5HPO4OH) bzw. ein Leerdefekt. Alle Zementformulierungen erwiesen sich als biokompatibel und osteokonduktiv. Bei den Struvit-Zementen (MgNH4PO4•6H2O) konnte nach 10 Monaten Implantation eine fast komplette Degradation beobachtet werden. Diese fand sowohl passiv durch chemisch-physikalische Lösungsvorgänge als auch aktiv, d.h. zellvermittelt, statt. Gleichzeitig bildete sich neues trabekuläres Knochengewebe, so dass gesagt werden kann, dass die Resorptions-geschwindigkeit der Geschwindigkeit der Knochenformation entsprach. Die mechanische Stabilität nahm zwar gegenüber den in vitro ermittelten Werten nach Implantation stark ab, wurde aber im Zeitverlauf durch das Einwachsen von neuem Knochengewebe wieder auf ein physiologisches Niveau angehoben. Signifikante Unterschiede zwischen den Porositäten gab es nur zum Teil hinsichtlich des verbliebenen Zementvolumens. Aufgrund der besseren Verarbeitbarkeit als injizierbare Paste, wäre ein Pulver-Flüssigkeits-Verhältnis von 2,0 eventuell besser für den klinischen Einsatz geeignet als ein Pulver-Flüssigkeits-Verhältnis von 3,0. In Kontakt mit Weichgewebe lösten sich die Struvit-Zemente schneller auf als neues Knochengewebe einwachsen konnte. Durch weitere Modifikationen bei der Zementzusammensetzung könnte dies verhindert werden. Durch die Kombination mit einem im Verhältnis zu Struvit stabileren Calciumphosphat (z.B. β-Tricalciumphosphat) könnte ein biphasischer Zement entwickelt werden, bei dem sich die einzelnen Komponenten unterschiedlich schnell auflösen. Die Bruschit-Zemente (CaHPO4•2H2O) und der CDHA-Zement zeigten selbst nach zehn Monaten Implantation kaum Degradation. Bei dem CDHA-Zement war dies zu erwarten, bei den Bruschit-Zementen jedoch nicht. Die Ursache hierfür kann bei der höheren Porosität (PLR 2,0) in der Phasenumwandlung von Bruschit zu Octacalciumphosphat bzw. generell in der Zementkomposition gesehen werden. Da die Bruschit-Zemente im teilbelasteten Defekt Risse aufwiesen, war ihre mechanische Stabilität in vivo für lasttragende Bereiche nicht ausreichend. Deshalb wäre es nötig, die Bruschit-Zemente weiter zu modifizieren, bevor sie erneut im Tiermodell untersucht werden können. Um die Stabilität zu verbessern, könnten Keramik- oder Polymerfasern in den Zement eingebracht werden. Für die Verbesserung der Degradation sollte eine andere Flüssigkeitskomponente, z. B. Natriumhyaluronat oder Pyrophosphat, wie sie in anderen Studien verwendet wurden, in Betracht gezogen werden. Zusätzlich zu den orthotopen Implantaten wurden jeweils auch subkutan Formkörper eingebracht. Diese zeigten, dass die untersuchten Zemente auch eine gewisse Osseoinduktivität besaßen. Im Fall der Bruschit-Zemente verhielten sich die subkutanen Implantate allerdings anders als die im Knochen implantierten Zemente. Im Gegensatz zu den orthotopen Implantaten zeigten die Formkörper im subkutanen Gewebe eingesetzt eine deutliche Größenreduktion. Die Ursache dafür kann im unterschiedlichen Gewebemilieu oder in der unterschiedlichen Implantatform (orthotop: Paste / heterotop: Block) gesehen werden. Um eine möglichst genaue Aussage über das biologische Verhalten eines Materials treffen zu können, ist es daher notwendig, die Materialien immer in der Form und im entsprechenden Zielgewebe zu untersuchen, wie sie später verwendet werden sollen, d.h. ein Zement als resorbierbares Knochenersatzmaterial sollte immer als Paste im Knochenlager untersucht werden. Auch eine Untersuchung in einem belasteten Implantationsmodell ist sinnvoll, da eine mechanische Belastung einen Einfluss auf das Verhalten der Zemente und das Knochenremodelling hat.
Osseointegration of cold-setting bone-cements in an ovine model The perfect bone substitute material which matches the properties of bone has still not been found. Therefore, intensive research is on-going. In the present study a calciumphosphate- and a magnesiumphosphate-cement (brushite and struvite respectively) were investigated. The cements were implanted in sheep using a partially loaded and an unloaded critical size bone defect. Each formulation was tested in two different powder-to-liquid-ratios (PLR 2.0 and 3.0), resulting in different porosities of the hardened cements. The implantation periods were 4, 7 and 10 months. For the 10 months’ group there were two controls: a CDHA cement (Ca9(PO4)5HPO4OH) and an unfilled defect. Every investigated cement formulation proved to be biocompatible and osteoconductive. After ten months of implantation in live sheep, the struvite cements (MgNH4PO4•6H2O) showed a nearly complete degradation which was closely followed by new trabecular bone formation. The degradation observed was both passive to chemical dissolution and active to cellular activity. The mechanical properties of the struvite-cements decreased extensively, up to 90 %, after implantation. However, over the ten months of this study, the stiffness level caused by the infilling bone reached normal physiological ranges. There were no significant differences between the porosities except in the area of residual cement in some cases. Nevertheless, for clinical use, a PLR of 2.0 would be preferable to a PLR of 3.0 because an injectable cement provides better handling. When the struvite cement is in contact with soft tissue, it dissolves too quickly for proper bone ingrowth. Therefore, further modifications to the cement formulation are required. For example, a biphasic cement could be developed in which the individual components dissolve at different rates. This could be achieved through the combination of struvite and a more stable calcium phosphate (eg, β-tricalcium phosphate). The brushite cements (CaHPO4•2H2O), as well as the CDHA cement, showed barely any resorption even after ten months of implantation. For the CDHA cement this was expected, but not for the brushite cements. These findings could be due to changes in the phase composition which occured in the brushite cements with a PLR of 2.0, rather than due to the cement formulation itself. The partially-loaded defect model revealed that the brushite cements were not suitable for load-bearing applications because cracks formed in the cement. Hence, it is recommended that the cement formulations be modified before they are investigated again. To enhance the stability, ceramic or polymer fibers might prove successful when incorporated into the cement. To improve degradation behavior, another liquid component such as sodiumhyaluronat or pyrophosphate, as used in other studies, should be considered. In addition to the bone implants, moulds of each cement formulation were implanted subcutaneousely. Bone formation at these implants exhibited certain osteoinductive properties of the cements. By the time of implantation, the subcutaneous brushite implants had reduced in volume in contrast to the bone implants. The cause may be found in the different tissue milieu or in the different implant type (orthotopic: paste / heterotopic: block). When researching the specific biological behaviours of a biomaterial, it is necessary to examine the materials using them with the same type and corresponding target tissue as it will be used in clinical use. In such cases, cements used as resorbable bone substitute materials should always be investigated as a paste and in a suitable bone defect. Also, a study in a loaded implant model is useful, since a mechanical load has an influence on the behavior of the cements and the bone remodelling.
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Herbert, Amy Angharad. "Bone grafting : tissue treatment and osseointegration." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55547/.

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Bone grafts fill skeletal defects and provide a structure upon which new bone can be deposited. There is no standard method of storing bone prior to grafting, the three main storage regimes being stored fresh frozen at -80°C, gamma irradiated or freeze dried. The initial aim of this project was to determine how osteoblastic cells behaved when exposed to bone treated in the above ways. It was found that sterilisation of bone with gamma irradiation caused cell death in a number of the cells that came into contact with it. Therefore the use of gamma irradiation for grafting is contraindicated, a similar observation was observed for freeze-dried bone whereas cells grew and differentiated on fresh frozen tissue. The second aim of this study was to develop a system whereby bone marrow cells could be expanded in culture and retain their osteogenic potential so that they would be suitable for either coating a bone graft (thus increasing the rate of osseointegration of the graft) or used alone to treat small bone defects. Rodent bone marrow was used in a variety of cultures and bone formation was induced by either BGJ-b medium or ECCM (Endothelial cell conditioned medium). Control cultures were grown in alpha modification minimum essential medium. ECCM was overall found to produce a greater number of cells at the end of the incubation periods studied than BGJ-b medium. BGJ-b medium preferentially selected mineralization over cell proliferation under all of the culture conditions studied (monolayers, collagen gels and organ cultures). This medium would be best suited to forming small pieces of bone rapidly from bone marrow, to fill small bone defects such as those seen in the dental field. ECCM produced large numbers of osteogenic cells, which could potentially be used to coat large bone grafts.
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Thomson, Seamus David. "Clinical and Laboratory Studies in Osseointegration." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20130.

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Osseointegration for lower limb amputees entails the anchorage of a percutaneous implant into the residual bone, where a prosthesis may be attached externally. The development of this technology was to overcome the shortcomings of conventional prostheses options for amputees including poor mobility outcomes, limited prosthesis use, and induction or amplification of major diseases. Little is known about the long-term success of Osseointegration, and there are gaps in the available literature of its physiological periprosthetic status for recipients. This body of work evaluates periprosthetic bone remodelling around two different types of osseointegrated prostheses, and bone remodelling in regions proximal to these types of implants. A new plasma-printing device designed for space technologies was appropriated to deposit biomaterials for implant surface coating purposes with material characterisation. Lastly, technology cross-over between space instrumentation and Osseointegration was evaluated in the context of the current problems faced by osseointegrated implant recipients and future implant designs. This dissertation outlines milestone clinical and laboratory findings in Osseointegration that will hopefully translate into new implant designs in context of the bone physiology results observed, and applications of new technologies. Overall, the future of Osseointegration appears promising and is likely to remain an impactful area of research for solving the issues associated with amputees.
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Pitchai, Manju Sofia. "Harnessing the immune response to enhance osseointegration." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/418638.

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New understanding of immune system biology has led a paradigm shift in the development of biomaterials away from classically ‘inert’, to ‘immuno-modulatory’ biomaterials that have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. This project aims to examine macrophage behavior and in particular integrin expression at the cell–biomaterial interface in vitro, in order to delineate the underlying molecular events occurring during biomaterial-mediated osseous healing. After reviewing the current literature to identify research gaps that this thesis should focus on, the activation of macrophages with controlled timing, and modulation of their interactions with other cell types involved in wound healing, emerged as key strategies to improve biomaterial efficacy. Careful design of biomaterial structure and controlled release of immunomodulators can be employed to manipulate macrophage phenotype for the maximization of the wound healing response with enhanced tissue integration and repair, however, to elicit predictable immune responses there is a need for a thorough understanding of how the biomaterial properties can be tuned to harness a designed immunological outcome. Our systematic review of in vitro studies suggested that the initial immune response of macrophages to titanium may be modulated by its surface characteristics both topographically and physiochemically. We therefore assessed the potential effects of three novel titanium surfaces; Machined, Blasted and Fluoride-treated, on macrophage phenotype. We chose a monocytic cell-line as our macrophage source rather than using primary macrophages, as the inflammatory status of primary cells could not be readily defined nor reproduced between experiments. This was crucial to the overall study if we were to clearly assess any changes in macrophage phenotype as a result of their II interaction with the titanium surfaces. We subsequently analysed in some detail the experimental processes involved in the optimization of macrophage cell culture, macrophage differentiation and phenotype characterization. We used microscopy, profilometry and elemental analysis to understand how the roughness of the titanium surfaces affected macrophage viability and proliferation in both non-activated ‘M0’ and activated inflammatory ‘M1’ macrophages. Subsequent analysis of one of the key mediators of cell attachment to biomaterials showed for the first time that αM, β1, β2 and α2 integrins play an important role in the adhesion of non-polarised M0 macrophages onto both smooth and rough titanium surfaces. Moreover, the distinct temporal expression profile of αM integrin expression correlated broadly with the subsequent secretion profiles of inflammatory cytokines IL-1β and TNF-α in these cells. Specific integrin expression also played an important role in the adhesion of polarised inflammatory M1 macrophages onto surface-modified titanium surfaces. In these cells, early integrin αM and β1 in particular, along with integrin α2 was associated with modulation of the subsequent cytokine response in these cells. Furthermore, the surface induced differential expression of integrins on the different titanium surfaces showed the Fluoride-modified surface in general induced greater cytokine and integrin modulation than either the Machined or Blasted surfaces. While now biologically plausible, further studies to fully determine how integrin-derived modulation of the macrophage-associated inflammatory response following macrophage attachment as suggested by these studies, can enhance wound healing and osteogenesis are required. Despite this, ‘harnessing the immune response’ is clearly a potential goal of engineered titanium implant surfaces in order ‘to enhance osseointegration’.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medicine & Dentistry
Griffith Health
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Silva, Manuel A. B. da. "Osseointegration bei dentalen Implantaten eine Literaturübersicht und -auswertung /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969451679.

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Bernhardt, Ricardo. "Dreidimensionale Charakterisierung der Osseointegration von Titanimplantaten mittels Mikrocomputertomographie." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1169046173395-60123.

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Die Entwicklung und Erprobung von metallischen Implantatwerkstoffen mit biologischen Beschichtungen für den Einsatz im menschlichen Knochen verlangt, neben der Untersuchung grundlegender zellbiologischer Wechselwirkungen, eine ganzheitliche Betrachtung ihrer Wirkungsweise im lebenden Organismus. Die vorwiegend angewandte Methode zur Quantifizierung des Potentials von Biofunktionalisierungen metallischer Implantate ist dabei die histologische Auswertung. Diese stützt sich aber auf Informationen aus nur wenigen und eher zufälligen Schnittlagen im Probenvolumen, was mit einer hohen Anzahl an Tierexperimenten ausgeglichen wird. Mit der Mikrocomputertomographie steht neben der klassischen Histologie eine zerstörungsfreie Methode zur Verfügung, welche eine detaillierte dreidimensionale Darstellung des neugebildeten Knochengewebes ermöglicht. Die Abbildungsqualität des mineralischen Knochengewebes um Titanimplantate, als Grundlage für eine Vergleichbarkeit von Tomographie und Histologie, wurde anhand von drei Mikrofokus-Computertomographen und einem Synchrotron-Computertomographen am HASYLAB untersucht. Die tomographische Untersuchung von Hartgewebe einschließlich metallischer Implantate zeigte mit Hilfe von Synchrotronstrahlung die beste qualitative Übereinstimmung zur histologischen Bildgebung. Für die Quantifizierung der Knochenneubildung wurden interaktive Analysemodelle erarbeitet, welche eine vereinheitlichte Auswertung von histologischen und tomographischen Informationen erlaubt. Auf Grundlage der entwickelten Analyseprozeduren war es erstmals möglich, die statistische Belastbarkeit der Ergebnisse aus der histologischen und tomographischen Analyse zu untersuchen. Dabei konnte gezeigt werden, dass hinsichtlich der Herausstellung von Unterschieden bei der Osseointegration modifizierter Titanimplantate mit beiden Methoden ähnliche Ergebnistrends gefunden werden. Eine Signifikanz (p < 0,01) der Unterschiede bei der Knochenneubildung konnte jedoch ausschließlich mit der mikrotomographischen Analyse herausgestellt werden. Die Ergebnisse bei der Darstellung und Analyse des mineralischen Gewebes durch die Nutzung der Synchrotrontomographie gehen weit über die Grenzen der histologischen Untersuchungen hinaus. Durch den dreidimensionalen Charakter der Informationen ergeben sich dabei neue Bewertungsmodelle zur Beurteilung der Osseointegration von biofunktionalisierten Implantaten. Die mikrotomographische Analyse führt gegenüber der histologischen Auswertung durch die geringe Irrtumswahrscheinlichkeit der Ergebnisse bei deutlich verminderter Probenanzahl zu einer erheblichen Verringerung von Tierversuchen.
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Sjostrom, Terje. "Nanopatterning of titanium surfaces for improved implant osseointegration." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503860.

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With increasingly higher performance requirements and health care costs associated with dental and orthopaedic bone-anchored implants there is a need to improve the osseointegration of Ti implants. Small alterations in nanotopography feature dimensions and arrangement has recently been shown able to differentiate human mesenchymal stem cells into an osteoblastic lineage, thus showing potential for using nanotopography to improve osseointegration of Ti implants.
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Shao, Fei. "Natural frequency analysis for osseointegration trans-femoral implant." Thesis, University of Surrey, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443397.

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Bernhardt, Ricardo. "Dreidimensionale Charakterisierung der Osseointegration von Titanimplantaten mittels Mikrocomputertomographie." Doctoral thesis, Technische Universität Dresden, 2006. https://tud.qucosa.de/id/qucosa%3A23934.

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Die Entwicklung und Erprobung von metallischen Implantatwerkstoffen mit biologischen Beschichtungen für den Einsatz im menschlichen Knochen verlangt, neben der Untersuchung grundlegender zellbiologischer Wechselwirkungen, eine ganzheitliche Betrachtung ihrer Wirkungsweise im lebenden Organismus. Die vorwiegend angewandte Methode zur Quantifizierung des Potentials von Biofunktionalisierungen metallischer Implantate ist dabei die histologische Auswertung. Diese stützt sich aber auf Informationen aus nur wenigen und eher zufälligen Schnittlagen im Probenvolumen, was mit einer hohen Anzahl an Tierexperimenten ausgeglichen wird. Mit der Mikrocomputertomographie steht neben der klassischen Histologie eine zerstörungsfreie Methode zur Verfügung, welche eine detaillierte dreidimensionale Darstellung des neugebildeten Knochengewebes ermöglicht. Die Abbildungsqualität des mineralischen Knochengewebes um Titanimplantate, als Grundlage für eine Vergleichbarkeit von Tomographie und Histologie, wurde anhand von drei Mikrofokus-Computertomographen und einem Synchrotron-Computertomographen am HASYLAB untersucht. Die tomographische Untersuchung von Hartgewebe einschließlich metallischer Implantate zeigte mit Hilfe von Synchrotronstrahlung die beste qualitative Übereinstimmung zur histologischen Bildgebung. Für die Quantifizierung der Knochenneubildung wurden interaktive Analysemodelle erarbeitet, welche eine vereinheitlichte Auswertung von histologischen und tomographischen Informationen erlaubt. Auf Grundlage der entwickelten Analyseprozeduren war es erstmals möglich, die statistische Belastbarkeit der Ergebnisse aus der histologischen und tomographischen Analyse zu untersuchen. Dabei konnte gezeigt werden, dass hinsichtlich der Herausstellung von Unterschieden bei der Osseointegration modifizierter Titanimplantate mit beiden Methoden ähnliche Ergebnistrends gefunden werden. Eine Signifikanz (p < 0,01) der Unterschiede bei der Knochenneubildung konnte jedoch ausschließlich mit der mikrotomographischen Analyse herausgestellt werden. Die Ergebnisse bei der Darstellung und Analyse des mineralischen Gewebes durch die Nutzung der Synchrotrontomographie gehen weit über die Grenzen der histologischen Untersuchungen hinaus. Durch den dreidimensionalen Charakter der Informationen ergeben sich dabei neue Bewertungsmodelle zur Beurteilung der Osseointegration von biofunktionalisierten Implantaten. Die mikrotomographische Analyse führt gegenüber der histologischen Auswertung durch die geringe Irrtumswahrscheinlichkeit der Ergebnisse bei deutlich verminderter Probenanzahl zu einer erheblichen Verringerung von Tierversuchen.
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Bonsignore, Lindsay Ann. "SURFACE CONTAMINANTS INHIBIT THE OSSEOINTEGRATION OF ORTHOPAEDIC IMPLANTS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1341323221.

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Books on the topic "Osseointegration"

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L, Berman Charles, ed. Osseointegration. Philadelphia: Saunders, 1989.

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Jokstad, Asbjorn, ed. Osseointegration and Dental Implants. Oxford, UK: Wiley-Blackwell, 2009. http://dx.doi.org/10.1002/9780813804644.

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Asbjorn, Jokstad, ed. Osseointegration and dental implants. Ames, Iowa: Wiley-Blackwell, 2008.

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Per-Ingvar, Brånemark, and Oliveira Marcelo Ferraz de, eds. Craniofacial prostheses: Anaplastology and osseointegration. Chicago: Quintessence Books, 1997.

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Philip, Worthington, Lang Brien R, and LaVelle William E. 1936-, eds. Osseointegration in dentistry: An introduction. Chicago: Quintessence Pub. Co., 1994.

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Choi, Andy H. Bone Remodeling and Osseointegration of Implants. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-1425-8.

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Per-Ingvar, Brånemark, Francischone Carlos Eduardo, and Vasconcelos Laércio Wonhrath, eds. Osseointegration and esthetics in single tooth rehabilitation. São Paulo: Quintessence Pub., 2000.

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Philip, Worthington, Naert I, and Steenberghe Daniel van, eds. Osseointegration in oral rehabilitation: An introductory textbook. London: Quintessence Pub., 1993.

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Engelman, Michael. Clinical decision making and treatment planning in osseointegration. Chicago: Quintessence Pub. Co., 1996.

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Philip, Worthington, and Brånemark Per-Ingvar, eds. Advanced osseointegration surgery: Applications in the maxillofacial region. Chicago: Quintessence Books, 1992.

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Book chapters on the topic "Osseointegration"

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Kadar, Abdul Aleem. "Osseointegration." In Encyclopedia of Otolaryngology, Head and Neck Surgery, 1947. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_200078.

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Webster, Joseph B., Kent N. Bachus, James Peter Beck, Sujee Jeyapalina, Alex J. Drew, and Roy D. Bloebaum. "Osseointegration Research." In Full Stride, 167–93. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7247-0_10.

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Reif, Taylor J., Austin T. Fragomen, and S. Robert Rozbruch. "Percutaneous Osseointegration Prosthesis." In Orthopedic Surgical Oncology For Bone Tumors, 265–72. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73327-8_26.

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Schenk, R. K. "Osseointegration of Sulmesh Coatings." In Endoprosthetics, 60–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79306-6_5.

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Albrektsson, T., and C. Johansson. "Osteoinduction, osteoconduction and osseointegration." In The Use of Bone Substitutes in Spine Surgery, 12–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-56071-2_3.

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Moreschini, Oreste, and Simone Pelle. "Biomechanics and Prosthetic Osseointegration." In Imaging of Prosthetic Joints, 39–51. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5483-7_4.

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Anderson, Ashley B., and Jonathan A. Forsberg. "The Mangled Extremity: Osseointegration." In The Mangled Extremity, 285–90. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-56648-1_18.

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Chakravorty, Nishant, Anjali Jaiprakash, Saso Ivanovski, and Yin Xiao. "Implant Surface Modifications and Osseointegration." In Springer Series in Biomaterials Science and Engineering, 107–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-53574-5_4.

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Janzen, Henry, Wes Miller, and Erik Wikman. "Craniofacial osseointegration and maxillofacial surgery." In Health-related disorders in children and adolescents: A guidebook for understanding and educating., 185–91. Washington: American Psychological Association, 1998. http://dx.doi.org/10.1037/10300-026.

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Le Béguec, Pierre, François Canovas, Olivier Roche, Mathias Goldschild, and Julien Batard. "Evaluation of Osseointegration and Secondary Stability." In Uncemented Femoral Stems for Revision Surgery, 77–83. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-03614-4_12.

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Conference papers on the topic "Osseointegration"

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VanSchoiack, Lindsey R., Veronica I. Shubayev, Robert R. Myers, and James C. Earthman. "In Vivo Monitoring of Osseointegration." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38078.

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The process of osseointegration is the firm anchoring of a surgical implant by the growth of bone around it without fibrous tissue formation at the interface. This process is critical for long-term implant success. The ability to monitor this process in vivo would allow for personalization of loading protocols to increase the rate of implant success overall by ensuring that implants are not over or under loaded during recovery. Accordingly, there is a strong need for an instrument that has the sensitivity to noninvasively measure osseointegration in vivo. One of the objectives of the present study was to assess the performance of an instrumented percussion probe for quantitatively monitoring the osseointegration process.
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Hsieh, Bin-Xun, Trinh Minh Cong, Chin-Sung Chen, and Min-Chun Pan. "Dynamic characterization of dental implant osseointegration." In 2016 International Conference on Biomedical Engineering (BME-HUST). IEEE, 2016. http://dx.doi.org/10.1109/bme-hust.2016.7782092.

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Giulianelli, M., L. Pastorino, R. Ferretti, and C. Ruggiero. "Polyelectrolyte multilayer coatings for implant osseointegration." In 2013 IEEE 13th International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2013. http://dx.doi.org/10.1109/bibe.2013.6701675.

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Dostalova, Tatjana, Miroslav Jelinek, Lucia Himmlova, and Christos Grivas. "Osseointegration of KrF laser hydroxylapatite films on Ti6A14V alloy by mini-pigs: loaded osseointegration of dental implants." In BiOS '99 International Biomedical Optics Symposium, edited by John D. B. Featherstone, Peter Rechmann, and Daniel Fried. SPIE, 1999. http://dx.doi.org/10.1117/12.348331.

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LU, SHOUXUN, BENJAMIN STEVEN VIEN, MATTHIAS RUSS, MARK FITZGERALD, and WING KONG CHIU. "EXPERIMENTAL INVESTIGATION ON A NOVEL OSSEOINTEGRATED IMPLANT STABILITY ASSESSMENT USING ON VIBRATION ANALYSIS." In Structural Health Monitoring 2021. Destech Publications, Inc., 2022. http://dx.doi.org/10.12783/shm2021/36348.

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Osseointegrated prostheses are widely used as the treatment for femur amputation. However, this technique requires sufficient implant stability before and during the rehabilitation period to mitigate the risk of implant breakage and loosening. Hence, reliable assessment methods for the osseointegration process are essential to ensure initial and long-term implant stability. This paper aims to investigate a vibration analysis method with a novel implant design, which focuses on the analysis of the dynamic response of the femur-implant system during the simulated osseointegration process. The paper also proposes a concept of using normalized energy difference to formulate an energy index (E-index). A 133mm-long amputated artificial femur model was constrained at the proximal end with a customized clamp. The epoxy adhesives were applied at the interface between the aforementioned femur and implant to simulate the change in stiffness in mimicking the osseointegration process. A two-unidirectionalsensor setup attached to the bottom of the implant was used to record the dynamic response stimulated by an impact hammer. The results show a significant change in magnitude of the cross-spectrum during the osseointegration processes. The resonance modes in cross-spectrum for the frequency above 1000Hz are hard to distinguish suggested that the vibration of the system being hindered by the high dampening effect of the adhesive before the initial bonding of the adhesive at 300s. The plot of E-index shows a clear correlation that the E-index provided a potential quantitative approach for monitoring the stages of osseointegration. These findings highlight the feasibility of using the vibration analysis technique and E-index to quantitatively monitor the osseointegration process for future improvement on the efficiency of human health monitoring and patient rehabilitation.
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Lu, S. "Investigation of vibrational assessment on osseointegration process with a novel implant design." In Structural Health Monitoring. Materials Research Forum LLC, 2023. http://dx.doi.org/10.21741/9781644902455-22.

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Abstract. Osseointegrated prosthesis has been utilized as an alternative treatment for transfemoral amputation to replace the common prosthetic sock device, which has been complained by patients as unsatisfactory due to the severe infection and pain. Osseointegrated prosthesis demonstrated enormous advantages in improving mobility and quality of life for the amputee. However, the long rehabilitation period, which forces patients to stay in bed for up to 18 months, limits the application of the osseointegrated implant. Therefore, accurate and quantitative assessment method attracts research interest in recent years. This paper investigates the capability of a vibrational analysis technique using two unidirectional sensors on monitoring stages of the osseointegration process. This assessment method has been proven to be sensitive to the stiffness change at the femur-implant interface due to osseointegration. This paper mainly focuses on the further validation of this vibrational method and E-index on three lengths of the residual femur. The colormap of the cross-spectrum against the curing time demonstrates a clear step change in the magnitude. Moreover, the E-index for these three lengths of residual femur shares a similar trend, which dramatically increases after 300s and peaks above 0.8. The time when the gradient of the E-index reaches its maximum is coincident with the initial bonding time of the epoxy adhesive which is used to simulate the osseointegration process. The clear correlation between E-index to the curing time evidences the capability of this vibrational method in monitoring the osseointegration process and the potential of the E-index being a quantitative parameter to assess the stage of the osseointegration process.
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Salvino, Liming W. "Monitoring osseointegration and developing intelligent systems (Conference Presentation)." In Sensors and Smart Structures Technologies for Civil, Mechanical, and Aerospace Systems, edited by Jerome P. Lynch. SPIE, 2017. http://dx.doi.org/10.1117/12.2264838.

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Giulianelli, M., L. Pastorino, R. Ferretti, and C. Ruggiero. "Biomimetic polyelectrolyte multilayer ultrathin films to promote osseointegration." In 2013 IEEE 13th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2013. http://dx.doi.org/10.1109/nano.2013.6721062.

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Dewi, Ratnawati Irma, Rubianto Muhammad, and Prahasanti Chiquita. "Titanium implant coating and their effect on osseointegration." In THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0036187.

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Pan, M. Ch, Z. W. Chen, H. B. Zhuang, and S. Y. Lee. "Technique and Device of Irregular Osseointegration Detection for Dental Implant." In ASME 2008 3rd Frontiers in Biomedical Devices Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/biomed2008-38039.

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This paper aims to develop detection techniques and associated devices on irregular osseointegration during and after dental implant operations. More specifically, the study relates to the quantitative evaluation of an osseointegration between a dental implant and an alveolar bone through examining differences of dynamic characteristics of the dental implant and irregular bone defects. Developed techniques are able to inspect quantity, orientation and depth of bone defect. The associated device to this purpose is designed based upon the application of acoustic induced excitation and vibration response.
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Reports on the topic "Osseointegration"

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Kalil, Eduardo, Khalila Cotrim, Karen Bechara, Leila Takakura, João Gabriel Souza, and Jamil Shibli. Osseointegration in osteoporotic sites – A systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2023. http://dx.doi.org/10.37766/inplasy2023.7.0115.

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Nelson, Daniel C. Engineered PlyCB as Novel Implant Coating for Osseointegration. Fort Belvoir, VA: Defense Technical Information Center, September 2011. http://dx.doi.org/10.21236/ada554576.

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Nelson, Daniel. Engineered PlyCB as a Novel Implant Coating for Osseointegration. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada562452.

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López-Valverde, Nansi, Javier Aragoneses, Antonio López-Valverde, Cinthia Rodríguez, and Juan Manuel Aragoneses. Role in the osseointegration of titanium dental implants, of bioactive surfaces based on biomolecules: A systematic review and meta-analysis of in vivo studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0076.

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Review question / Objective: Does the bioactive surface of titanium dental implants, based on biomolecules, influence osseointegration?. The aim of our study was to evaluate the role and efficacy of bioactive surfaces in osseointegration. Our review study limited the research interest to titanium dental implants coated with a biomolecule, i.e., an organic molecule produced by a living organism. Condition being studied: In recent years, much attention has been paid to topographical modifications of dental implant surfaces, as well as to their coating with biologically active substances.a bioactive surface is one capable of achieving faster and higher quality osseointegration, shortening waiting times and solving situations of poor bone quality. Molecules that can be applied for bioactive purposes include bioceramics, ions and biomolecules. Collagen and bone morphogenetic protein have been suggested as bone stimulating agents. Biofunctionalization of the implant surface with a biomimetic active peptide has also been shown to result in a significant increase in bone-to-implant ratios and an increase in peri-implant bone density.
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Cuenin, Michael F., Michael A. Billman, Benjamin S. Hanson, and Val L. Kudryk. The Effects of Estrogen and Progesterone Levels on Osseointegration of Dental Implants. Fort Belvoir, VA: Defense Technical Information Center, October 1996. http://dx.doi.org/10.21236/ada328380.

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Vélez, Rómulo Andrés, Alejandro Fereño Caceres, Wilson Daniel Bravo Torres, Daniela Astudillo Rubio, and Jacinto José Alvarado Cordero. Primary stability with the osseodensification drilling technique for dental implants in low density bone in humans: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0066.

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Review question / Objective: - Does the osseodensification drilling technique increase primary stability in low-density bone? - The aim of the present investigation was to evaluate primary stability in dental implants in people with low density bone using the osseodensification technique. Condition being studied: The replacement of missing teeth through dental implants is currently the most practiced in dental clinics. The main criterion for determining the success of an implant is osseointegration, which is a direct structural and functional connection between vital bone and the prosthetic load-bearing surface of an implant. In the same way, primary stability must be obtained for a good lasting clinical result of the implant and to achieve this purpose, the bone density must be evaluated where the dental implant is to be placed. Salah Huwais in 2013 introduced a new osteotomy procedure (Oseodensification) for site preparation without removal and bone preservation. The Osseodensification process produces an autograft layer around the implant with the osteotomy surface, the autologous bone comes into contact through an endosteal device that accelerates osseointegration due to the nucleation of osteoblasts in the instrumented bone adjacent to the implant and has a greater primary stability due to contact between the device and the bone.
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Koay, Chun Giok, Teng Fung Looi, and Rohit Kunnath Menon. Systematic review of studies evaluating the microbiome of periimplantitis using next generation sequencing techniques. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0111.

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Review question / Objective: This systematic review aims to summarize and critically analyse the methodology and findings of studies which have utilized sequencing techniques to elucidate the microbial profiles of peri-implantitis. Condition being studied: Peri-implantitis is defined as an infection of the peri-implant tissues accompanied by suppuration and clinically significant progressing crestal bone loss after the adaptive phase, leading to decreased osseointegration and pocket formation. Eligibility criteria: Original studies investigating the microbiome of peri-implant tissues through next-generation DNA sequencing methods will be included. Culture-based study, conference papers, review articles, studies regarding peri-implantitis associated with other systematic factors (smoking, diabetes mellitus, etc.), articles that examine only specific microorganisms will be excluded from this systematic review. Non-English language articles and research conducted on non-human specimens will be excluded.
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