Journal articles: 'OSSC'

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Rahman, Ataur, Kyaw Myo Aung, Sany Ihsan, Raja Mazuir Raja Ahsan Shah, Mansour Al Qubeissi, and Mohannad T. Aljarrah. "Solar Energy Dependent Supercapacitor System with ANFIS Controller for Auxiliary Load of Electric Vehicles." Energies 16, no. 6 (March 13, 2023): 2690. http://dx.doi.org/10.3390/en16062690.

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Innovations are required for electric vehicles (EVs) to be lighter and more energy efficient due to the range anxiety issue. This article introduces an intelligent control of an organic structure solar supercapacitor (OSSC) for EVs to meet electrical load demands with solar renewable energy. A carbon fibre-reinforced polymer, nano zinc oxide (ZnO), and copper oxide (CuO) fillers have been used in the development of OSSC prototypes. The organic solar cell, electrical circuits, converter, controller, circuit breaker switch, and batteries were all integrated for the modelling of OSSCs. A carbon fibre (CF)-reinforced CuO-doped polymer was utilised to improve the concentration of electrons. The negative electrodes of the CF were strengthened with nano ZnO epoxy to increase the mobility of electrons as an n-type semiconductor (energy band gap 3.2–3.4 eV) and subsequently increased to 3.5 eV by adding 6% π-carbon. The electrodes of the CF were strengthened with epoxy-filled nano-CuO as a p-type semiconductor to facilitate bore/positive charging. They improve the conductivity of the OSSC. The OSSC power storage was controlled by an adaptive neuro-fuzzy intelligent system controller to meet the load demand of EVs and auxiliary battery charging. Moreover, a fully charged OSSC (solar irradiance = 1000 W/m2) produced 561 W·h/m2 to meet the vehicle load demand with 45 A of auxiliary battery charging current. Therefore, the OSSC can save 15% in energy efficiency and contribute to emission control. The integration of an OSSC with an EV battery can minimise the weight and capacity of the battery by 7.5% and 10%, respectively.

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Ding, Mingyi, Xianrong Gu, Lidan Guo, Rui Zhang, Xiangwei Zhu, Rongjin Li, Xiaotao Zhang, Wenping Hu, and Xiangnan Sun. "The prospects of organic semiconductor single crystals for spintronic applications." Journal of Materials Chemistry C 10, no. 7 (2022): 2507–15. http://dx.doi.org/10.1039/d1tc04333a.

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Mouakhar, Khaireddine, and Albéric Tellier. "How do Open Source software companies respond to institutional pressures? A business model perspective." Journal of Enterprise Information Management 30, no. 4 (July 10, 2017): 534–54. http://dx.doi.org/10.1108/jeim-05-2015-0041.

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Purpose Open Source software companies (OSSCs) are confronted with institutional pressures from Open Source software (OSS) communities. They must find an acceptable balance between the expectations of these communities and their own business model. However, there are still few studies that try to analyse the OSSC business models. The purpose of this paper is to highlight OSSC typical business models by using rich empirical data. Design/methodology/approach The methodology is based on a combination of quantitative analysis of a sample of 66 OSSCs and qualitative analysis of three typical situations resulting from that sample. Findings The quantitative study enables the authors to highlight three typical business models. The in-depth study of three typical cases enables the authors to specify these OSSC business models. The authors can distinguish four key dimensions: the relationship developed with the OSS communities, the strategic manoeuvres made, the key resources and competitive positioning. Research limitations/implications The results indicate that it is possible for firms to accommodate both profit and non-profit logics using different strategic manoeuvres to position themselves with regard to the Open Source institutional environment. Such accommodation requires the development of key resources and the adoption of suitable competitive positioning. Practical implications This study allows the authors to highlight two main practical contributions for OSSCs’ directors. First, the different manoeuvres identified may help them to ensure coherence between their strategic choices and the business model chosen. Second, the results can help OSSC founders identify value creation mechanisms more clearly by analysing four key variables. Originality/value This paper provides new insight about OSSCs business models. It aggregates four dimensions that provide a more “fine-grained” analysis of business models, while other studies often emphasise one dimension (usually the regime of appropriability).

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Sohn, Eunjin, Junghyun Kim, Chan-Sik Kim, Kyuhyung Jo, and Jin Sook Kim. "Osteomeles schwerinae Extract Prevents Diabetes-Induced Renal Injury in Spontaneously Diabetic Torii Rats." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/6824215.

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Mesangial cell proliferation contributes to the development of glomerulosclerosis in diabetic nephropathy. This study was aimed at determining whether Osteomeles schwerinae (OSSC) extract can ameliorate renal damage in Spontaneously Diabetic Torii (SDT) rats. OSSC extract (100 and 250 mg/kg/day) was administered to the SDT rats through oral gavage for 17 weeks. At the end of the experiment, glucose, HbA1c, and albuminuria were measured. In addition, the levels of mesangial proliferation-related proteins were determined by western blotting and immunohistochemistry. Our results show that albuminuria, accumulation of the extracellular matrix (ECM), and renal expansion were markedly restored by OSSC extract administration. The OSSC treatment also inhibited α-smooth muscle actin and transforming growth factor-β1 protein expression. In addition, OSSC and its bioactive compounds hyperoside and quercitrin inhibited the platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor-B receptor (PDGFR-β) ligand binding in an in vitro assay. Taken together, these results indicate that OSSC inhibits ECM accumulation and mesangial proliferation of the glomeruli in SDT rats through inhibition of the interaction between PDGF-BB and PDGFR-β. OSSC has ameliorating effects on the initiation and progression of diabetes complications and can be used for the treatment of early diabetic renal dysfunction.

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Pyun, Bo-Jeong, Young Sook Kim, Ik Soo Lee, Dong Ho Jung, Joo-Hwan Kim, and Jin Sook Kim. "Osteomeles schwerinae Extract and Its Major Compounds Inhibit Methylglyoxal-Induced Apoptosis in Human Retinal Pigment Epithelial Cells." Molecules 25, no. 11 (June 3, 2020): 2605. http://dx.doi.org/10.3390/molecules25112605.

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The accumulation and formation of advanced glycation end products (AGEs) are related to diabetes and age-related disease. Osteomeles schwerinae C. K. Schneid. (Rosaceae, OSSC) is used traditionally for the treatment of various diseases in Asia. Previous studies have shown that OSSC elicits preventive effects in an in vivo model of diabetes. This study was to evaluate the antiapoptotic effects of dried leaves and twigs of OSSC extract and its major compounds in ARPE-19 cells—spontaneously arising human retinal pigment epithelial cells—under diabetic conditions. To examine the effects of an OSSC extract and its active compounds (acetylvitexin, hyperoside and quercitrin) on apoptosis in methylglyoxal (MG, the active precursor in the formation of AGEs)-treated ARPE-19 cells and the mechanism by which these effects occur, apoptosis was measured using flow cytometry analysis. Protein expression levels of phospho-p53 (p-p53), Bax and Bcl-2 were determined by western blot analyses. The OSSC extract inhibited apoptosis in MG-treated ARPE-19 cells in a dose-dependent manner. The major compounds also reduced the rate of apoptosis. Both the extract and major compounds also inhibited the expression of p-p53 and Bax and increased the levels of Bcl-2 that had been previously reduced by MG treatment. The OSSC extract (0.1 μg/mL) and its major compounds (0.01 μM) attenuated apoptosis in ARPE-19 cells under toxic diabetic conditions by downregulating of expression of p-p53 and Bax. OSSC may serve as an alternative therapy to retard the development of diabetic retinopathy.

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Abdo, Evandro Neves, Jeane de Fátima Correia-Silva, Carolina Cavaliéri Gomes, Isabela Almeida Pordeus, and Ricardo Santiago Gomez. "Serotonin transporter gene polymorphisms: a case-control study." Brazilian Dental Journal 23, no. 1 (2012): 68–71. http://dx.doi.org/10.1590/s0103-64402012000100012.

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Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). As alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-HTTLPR polymorphism in patients with oral squamous cell carcinoma (OSCC) compared with a control group in a sample of Brazilian patients. One hundred and three patients affected by OSCC and 103 volunteers without OSCC were genotyped for 5-HTTLPR. Both groups were matched for age, sex and tobacco use. The chi-squared test was used for statistical analysis (α=0.05). There was no statistically significant difference in 5-HTTLPR genotypes between case and control group (p= 0.408). In conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the OSSC development.

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Bogusiak, Katarzyna, Aleksandra Puch, Radosław Mostowski, Marcin Kozakiewicz, Piotr Paneth, and Józef Kobos. "Characteristic of Oral Squamous Cell Carcinoma Tissues Using Isotope Ratio Mass Spectrometry." Journal of Clinical Medicine 9, no. 11 (November 22, 2020): 3760. http://dx.doi.org/10.3390/jcm9113760.

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Overall prognosis for patients with oral squamous cell carcinomas (OSSC) is still unfavourable. However, there is a hope that a novel diagnostic method may establish better cancer biology characteristics. The aim of this study was to evaluate the isotope ratio of nitrogen and carbon in OSSC as compared to margin and healthy tissue. A total of 18 patients with OSSC were included in the study. Specimens collected covered: four tumour, four margin and two healthy oral mucosa samples. The samples underwent further procedures: lyophilization and isotope ratio mass spectrometry. Measurements of the ratio of stable isotopes of nitrogen 15N/14N and carbon 13C/12C were performed. It is noticeable that the highest average nitrogen concentration was observed in tumour 12 ± 0.4% and the lowest in healthy tissues 8 ± 0.9% (p < 0.00001). The highest average carbon content was observed in healthy tissues 57 ± 2.2% and the lowest in tumour 46 ± 1.3% (p < 0.00001). Moreover, values of 15N/14N expressed in delta notation were the highest in healthy tissues 9.84 ± 0.61 and the lowest in tumour 8.92 ± 0.58. Values of 13C/12C tended to be higher in tumour −22.2 ± 0.89 and the lowest in healthy tissues −23.7 ± 1.2. Tumour tissues differ in isotopic composition from tissues taken from margin and healthy tissues taken from distant oral mucosa.

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Chen, Yuting, and Ming Li. "An Effective Online Sequential Stochastic Configuration Algorithm for Neural Networks." Sustainability 14, no. 23 (November 23, 2022): 15601. http://dx.doi.org/10.3390/su142315601.

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Random Vector Functional-link (RVFL) networks, as a class of random learner models, have received careful attention from the neural network research community due to their advantages in obtaining fast learning algorithms and models, in which the hidden layer parameters are randomly generated and remain fixed during the training phase. However, its universal approximation ability may not be guaranteed if the random parameters are not properly selected in an appropriate range. Moreover, the resulting random learner’s generalization performance may seriously deteriorate once the RVFL network’s structure is not well-designed. Stochastic configuration (SC) algorithm, which incrementally constructs a universal approximator by obtaining random hidden parameters under a specified supervisory mechanism, instead of fixing the selection scope in advance and without any reference to training information, can effectively circumvent these awkward issues caused by randomness. This paper extends the SC algorithm to an online sequential version, termed as an OSSC algorithm, by means of recursive least square (RLS) technique, aiming to copy with modeling tasks where training observations are sequentially provided. Compared to the online sequential learning of RVFL networks (OS-RVFL in short), our proposed OSSC algorithm can avoid the awkward setting of certain unreasonable range for the random parameters, and can also successfully build a random learner with preferable learning and generalization capabilities. The experimental study has shown the effectiveness and advantages of our OSSC algorithm.

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de Zeeuw, Eveline L., Lykle Voort, Ruurd Schoonhoven, Michel G. Nivard, Thomas Emery, Jouke-Jan Hottenga, Gonneke A. H. M. Willemsen, et al. "Safe Linkage of Cohort and Population-Based Register Data in a Genomewide Association Study on Health Care Expenditure." Twin Research and Human Genetics 24, no. 2 (April 2021): 103–9. http://dx.doi.org/10.1017/thg.2021.18.

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AbstractThere are research questions whose answers require record linkage of multiple databases that may be characterized by limited options for full data sharing. For this purpose, the Open Data Infrastructure for Social Science and Economic Innovations (ODISSEI) consortium has supported the development of the ODISSEI Secure Supercomputer (OSSC) platform that allows researchers to link cohort data to data from Statistics Netherlands and run large-scale analyses in a high-performance computing (HPC) environment. Here, we report a successful record linkage genomewide association (GWA) study on expenditure for total health, mental health, primary and hospital care, and medication. Record linkage for genotype data from 16,726 participants from the Netherlands Twin Register (NTR) with data from Statistics Netherlands was accomplished in the secure OSSC platform, followed by gene-based tests and estimation of total and single nucleotide polymorphism (SNP)-based heritability. The total heritability of expenditure ranged between 29.4% (SE 0.8) and 37.5% (SE 0.8), but GWA analyses did not identify SNPs or genes that were genomewide significantly associated with health care expenditure. SNP-based heritability was between 0.0% (SE 3.5) and 5.4% (SE 4.0) and was different from zero for mental health care and primary care expenditure. We conclude that successfully linking genotype data to administrative health care expenditure data from Statistics Netherlands is feasible and demonstrates a series of analyses on health care expenditure. The OSSC platform offers secure possibilities for analyzing linked data in large scale and realizing sample sizes required for GWA studies, providing invaluable opportunities to answer many new research questions.

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Awan, Ayesha Mukhtar, Iram Naz, Muhammad Khurram Mahmood, and Hafeez Uddin. "EXPRESSION OF MATRIX METALLOPROTEINASE-9 IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL PSEUDOEPITHELIOMATOUS HYPERPLASIA." Gomal Journal of Medical Sciences 18, no. 01 (March 31, 2020): 24–29. http://dx.doi.org/10.46903/gjms/18.01.2120.

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Background: Oral pseudoepitheliomatous hyperplasia (PEH) appears histologically similar to oral squamous cell carcinoma (OSCC) in small oral biopsies, thus posing diagnostic dilemma. The objective of this study was to compare the expression of matrix metalloproteinase-9 (MMP-9) in differential diagnosis of OSSC and oral PEH. Materials & Methods: This comparative cross-sectional study was conducted in the Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan from January 2013 to March 2016. It included sixty archival cases, 30 each of OSCC and PEH. Paraffin embedded blocks were prepared, hematoxylin and eosin stained sections taken and immunostained with MMP-9. The expression of MMP-9 was evaluated in OSCC and PEH. Results: The OSCC group included 16 (53.33%) men and 14 (46.67%) women, whereas PEH group included 18 (60%) men and 12 (40%) women. The mean age of OSCC group was 60.1±17.3 and that of PEH group was 52.7±16.6. In OSCC group, site of lesion was buccal mucosa in 12 (40%), gingiva 10 (33.33%), tongue 7 (23.33%) and floor of mouth 1 (3.34%) case. In PEH group, site of lesion was buccal mucosa in 12 (40%), tongue 11 (36.66%), gingiva 6 (20%) and palate 1 (3.34%) case. The expression of MMP-9 was positive in all the 30 cases of OSCC and negative in all 30 cases of PEH. Conclusion: Compared to pseudoepitheliomatous hyperplasia (PEH), MMP-9 revealed a higher expression in oral squamous cell carcinoma (OSCC). This finding has become mainstream strategy in distinguishing OSCC from PEH in oral mucosal biopsies in cases difficult to diagnose.

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Alves, Alessandro Menna, Marcos Britto Correa, Karine Duarte da Silva, Lenita Maria Aver de Araújo, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, Adriana Etges, and Sandra Beatriz Chaves Tarquinio. "Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population." Brazilian Dental Journal 28, no. 3 (June 2017): 301–6. http://dx.doi.org/10.1590/0103-6440201601257.

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Abstract The aim of this study was to evaluate the demographic and clinical profile of the oral squamous cells carcinoma (OSCC) cases registered in a center of oral diagnosis in southern Brazil. Eight hundred and six individuals with OSCC from 1959 to 2012 were included in this study. The variables recorded were: sex, age, occupation according to workplace, alcohol and tobacco consumption, skin color, tumor location, histological type, clinical appearance, size, evolution time, presence of pain and lymph node metastasis. Descriptive analysis was performed and the associations between variables were assessed using the chi-square and Fisher’s exact test, with a confidence level of 5%. OSSC was more common in males (76.6%) aged between 51 to 70 years (53.9%). The most frequent sites were lower lip vermilion (23.3%), tongue (20.2%) and gingiva/alveolar ridge (18.1%). There was a strong association between outdoor occupation and white skin color with lip squamous cell carcinoma (LSCC). OSCC intraoral lesions were commonly more painful, larger than 2 cm and presented lymphatic metastasis. In conclusion, most of the results confirm the data from literature about sex, age, tumor location and occupation. Moreover, the positive correlations between LSCC and occupation, between LSCC and white skin color, and between bigger lesions and presence of pain/cervical metastasis also corroborate the literature data.

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Ries, Jutta, Nur Mollaoglu, Takeshi Toyoshima, Eleftherios Vairaktaris, Friedrich W. Neukam, Sabine Ponader, and Emeka Nkenke. "A novel Multiple-Marker Method for the Early Diagnosis of Oral Squamous Cell Carcinoma." Disease Markers 27, no. 2 (2009): 75–84. http://dx.doi.org/10.1155/2009/510124.

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Objective: Melanoma associated antigens-A (MAGE-A) expression is highly specific to cancer cells. Thus, they can be the most suitable targets for the diagnosis of malignancy. The aim of this study was to evaluate the sensitivity of multiple MAGE-A expression analysis for the diagnosis of oral squamous cell carcinoma (OSCC).Methods: Total of 70 OSSC and 20 normal oral mucosal (NOM) samples of otherwise healthy volunteers were examined for the expression of 10 different single antigens out of 12 different MAGE-A subtypes by highly sensitive reverse transcriptase polymerase chain reaction (RT-PCR) methods. The results were correlated to clinicopathological parameters of tumor samples.Results: Expression of MAGE-A was restricted to OSCC. The expression frequency of single antigen was between 10% and 55%. However, expression rate was increased up to 93% by the elevated number of genes examined. A significant correlation was found between the expression of MAGE-A and malignancy (p = 0.0001). In addition, multiple MAGE-A detection has also correlated to the incidence of lymph node metastasis, grading and advanced clinical stages.Conclusions: Analysis of multiple MAGE-A expression is more sensitive than the analysis of a single MAGE-A for the diagnostic evaluation of OSCC. Multiple MAGE-A expression analysis may be a very sensitive method to be used for the diagnosis even in the early stage of OSCC.

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Wang, Yongsheng, Yongfeng Zhu, Yan Liu, Bin Mu, and Aiqin Wang. "Slow Release and Water Retention Performance of Poly(acrylic acid-co-acrylamide)/Fulvic Acid/Oil Shale Semicoke Superabsorbent Composites." Polymers 14, no. 9 (April 22, 2022): 1719. http://dx.doi.org/10.3390/polym14091719.

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In order to achieve the low cost and multifunction of superabsorbent composites, poly(acrylic acid-co-acrylamide)/fulvic acid/oil shale semicoke (PAMFS) were prepared by free radical copolymerization of fulvic acid (FA), oil shale semicoke (OSSC), acrylic acid (AA) and acrylamide (AM). The characterization results revealed that FA and OSSC were involved in the construction of a three-dimensional (3D) polymeric network via hydrogen bonding and covalent bonding. The water absorbency of PAMFS in distilled water and 0.9 wt% NaCl solution were 724 and 98 g/g, respectively. The FA slow release of PAMFS in distilled water and soil was achieved due to the interaction between FA and the functional groups of polymer matrix by hydrogen bonds and covalent bonds. Furthermore, the potted experiment indicated that the addition of PAMFS to soil can significantly promote plant growth compared with the pure soil, regardless of water stress. Therefore, this superabsorbent composite showed an excellent water absorption and salt resistance performance, as well as nice slow release performance. It has a broad application prospect.

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Ali, Karishma, Sadaf Alam, Muhammad Mumtaz Khan, Natasha Kamran, Sara Zia, Shabana Bakhtiar, Sikandar Ali, Fatima Ali, and Irfan Ullah. "Expression of P16 in Various Grades of Oral Squamous Cell Carcinoma of Tertiary Care Hospitals of Peshawar." Pakistan Journal of Medical and Health Sciences 16, no. 7 (July 30, 2022): 626–29. http://dx.doi.org/10.53350/pjmhs22167626.

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Introduction: Oral squamous carcinoma (OSCC) is one of the ten most common carcinomas in the world. The survival rate of OSSC is poor due to its diagnosis at advanced stages, The main function of p16 in the body is to halt the tumor process, but genetic mutation may result in the development of OSCC. Objectives: The aim and objective was to compare the immunohistochemical expression of p16 in various grades of oral squamous cell carcinoma. Materials and Methods: This study was a retrospective comparative cross-sectional (Analytical) study. It was conducted at the Department of Pathology, Peshawar Medical College from August 2020 to August 2021. The sample size was calculated through G Power and 103 patients were included in the study. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) version 20.0. Chi-Square test was performed for categorical variables. Results: It was observed in our study that the mean age of OSCC was 59.16 ± 13 SD. The commonest effected age was 61-70 years (29%). The male to female ratio was approximately 1.2:1. The most common site involved by OSCC was buccal mucosa (n=49, 47%) followed by the tongue (n = 29, 29%). The p16 expression was positive in most OSCC were well differentiated (n=50, 92.5%), followed by moderately differentiated cases (n=26, 92.8%) and poorly differentiated (n=81, cases, 85.7%). There was no significant difference for p16 expression and grades of OSCC cases (P- value =0.601). Conclusion: The expression of p16 was more common in Well-differentiated oral squamous cell carcinoma, followed by moderately and poorly differentiated OSCC. Keywords: Oral Squamous cell carcinoma, P16, Human Papillomavirus

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Notarstefano, Valentina, Alessia Belloni, Simona Sabbatini, Chiara Pro, Giulia Orilisi, Riccardo Monterubbianesi, Vincenzo Tosco, Hugh J. Byrne, Lisa Vaccari, and Elisabetta Giorgini. "Cytotoxic Effects of 5-Azacytidine on Primary Tumour Cells and Cancer Stem Cells from Oral Squamous Cell Carcinoma: An In Vitro FTIRM Analysis." Cells 10, no. 8 (August 19, 2021): 2127. http://dx.doi.org/10.3390/cells10082127.

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In the present study, the cytotoxic effects of 5-azacytidine on primary Oral Squamous Cell Carcinoma cells (OSCCs) from human biopsies, and on Cancer Stem Cells (CSCs) from the same samples, were investigated by an in vitro Fourier Transform InfraRed Microscospectroscopy (FTIRM) approach coupled with multivariate analysis. OSCC is an aggressive tumoral lesion of the epithelium, accounting for ~90% of all oral cancers. It is usually diagnosed in advanced stages, and this causes a poor prognosis with low success rates of surgical, as well as radiation and chemotherapy treatments. OSCC is frequently characterised by recurrence after chemotherapy and by the development of a refractoriness to some employed drugs, which is probably ascribable to the presence of CSCs niches, responsible for cancer growth, chemoresistance and metastasis. The spectral information from FTIRM was correlated with the outcomes of cytotoxicity tests and image-based cytometry, and specific spectral signatures attributable to 5-azacytidine treatment were identified, allowing us to hypothesise the demethylation of DNA and, hence, an increase in the transcriptional activity, together with a conformational transition of DNA, and a triggering of cell death by an apoptosis mechanism. Moreover, a different mechanism of action between OSSC and CSC cells was highlighted, probably due to possible differences between OSCCs and CSCs response.

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Bhuyan, Ruchi, Sanat Kumar Bhuyan, Nihar Ranjan Panda, and Jatindra Mohanty. "Age and gender demographic and statistical analysis in oral squamous cell carcinoma in Eastern India." Journal of Associated Medical Sciences 56, no. 1 (January 2, 2023): 35–39. http://dx.doi.org/10.12982/jams.2023.005.

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Background: Oral squamous cell carcinoma (OSCC) continues to dominate all the oral cancer cases with premalignant disorders, which can also be predictable at the pre-clinical phase of malignancy. Chewing behaviors such as betel quid, areca nut& tobacco are all major risk factors. The majority of OSCC patients present with advanced disease and a poor prognosis. Despite the high prevalence of this cancer, there is a scarcity of rigorous data from Eastern India on its relationship with known risk factors. Objectives: The aim of this study was to evaluate the features at specific ages and gender that could play a major role in the development of oral squamous cell carcinoma. Materials and methods: Demographics and habitual behavior were both subjected to expressive analysis. In patients with oral squamous cell carcinoma, categorical and continuous variables regarding gender were scrutinized. Results: Age with gender cross tabs results reflects the maximum patients 245 (57.24%) were female at the age of 45-64, followed by the same age group male 480 (51.39%). The highest 654 cancer sites were found in the buccal mucosal region, and we found the total number of 349 (53.36%) were in the same age group between 45-64 years. Precisely we got the age mean±SD of 61±9 male and 64±12 female OSSC patients with statistical significance of <0.001 respectively. Conclusion: Finally, the majority of OSCC cases in our area of eastern India were female patients who had been using gudhakhu for a long time and it was found correlating with site of OSCC in female.

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Farrapo, Manuela Timbó, Tainah Oliveira Rifane, Diego Neves Pinto, Ranyele Elis Alexandre Rodrigues, Ketelyn Kerty Pereira de Oliveira, Samara Tabata Cavalcante Braga Medeiros, Luane Macedo de Sousa, Lorena Vieira Vasconcelos, and Victor Pinheiro Feitosa. "Via de sinalização WNT canônica no prognóstico de carcinoma de células escamosas oral." Research, Society and Development 11, no. 2 (January 18, 2022): e8411225462. http://dx.doi.org/10.33448/rsd-v11i2.25462.

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O objetivo do estudo foi evidenciar a expressão imuno-histoquímica da via wnt/b-catenina em células de carcinomas orais (OSCC), por meio de uma revisão da literatura. Para isso, foi realizado uma busca nos bancos de dados PubMed e SciELO com as paravras chaves “β-catenin”, “oral squamous cell carcinoma”, “OSCC” e “Wnt signaling” com operador booleano AND. Como critérios de inclusão adotaram-se artigos publicados na língua inglesa, artigos in vitro, in situ ou ensaios clínicos dos anos de 2010 a 2021 que relacionam a via de sinalização WNT canônica com oral squamous cell carcinoma e os critérios de exclusão considerados foram artigos duplicados, revisão de literatura e que não abordavam a temática. Após a leitura do título, do resumo, e do conteúdo integral de cada um dos estudos, foram selecionados 110 artigos. Compostos de IncRNA, enzimas, derivados de hexaclorofeno e a lignina isolada de Taiwania foram capazes de suprimir o crescimento e metástases pela inibição da via WNT/ β-catenina. Células-tronco cancerosas, enzimas tipo PON2, ingestão de nicotina, citocina TNF-α e gene FAD1 são capazes de aumentar o crescimento e metástase pela inibição da mesma via. Portanto, a expressão desses biomarcadores pode influenciar o prognóstico das células cancerígenas e ajudar os profissionais a explorar novos possíveis efeitos terapêuticos em OSSC modulando a via Wnt / β-catenina.

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Narayanan, Maithrea Suresh, Nur Karyatee Kassim, Tang Liszen, Baharuddin Abdullah, Julia Omar, Suhaily Mohd Hairon, and Norhafiza Mat Lazim. "The Utility of Beta 2 Microglobulin (B2M) as an Initial Diagnostic Tool for Oral Squamous Cell Carcinoma (OSCC): Evidence from a Malaysian Scenario." Bangladesh Journal of Medical Science 18, no. 4 (August 30, 2019): 729–35. http://dx.doi.org/10.3329/bjms.v18i4.42876.

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Background: The delay in diagnosis of oral squamous cell carcinoma (OSCC) is a factor in rendering the poor prognosis, and recent research has explored the use of serum tumour markers such Beta 2 Microglobulin (B2M), to aid early diagnosis. However, despite a high incidence of OSCC in Southeast Asia, no studies on the clinical use of B2M in the region were found. Objectives: To determine if serum B2M level can serve as an initial diagnostic tool to indicate if a biopsy is warranted, and if so, to propose a local B2M serum reference value to identify OSSC patients. Methodology: Twenty-one patients were seen at Hospital Universiti Sains Malaysia (HUSM) for a one-year period, between June 2016 and June 2017, and equal number of healthy controls participated in the study. Apart from patient history, venous blood of approximately 5ml volume was collected from each subject at the pre-treatment stage and analysed by an Abbot ARCHITECT c8000 analyser using the immunoturbidimetry method. The results were analysed using ROC analysis and the Mann Whitney test. Results: Serum B2M levels showed a statistically significant increase (p<0.001) in patients compared to controls. The test was shown to have 90.5% sensitivity and 90.5% specificity. It was found to be a sensitive and specific serum tumour marker at a cut off value of 1.57mg/l to differentiate cases from controls. Conclusion: B2M is a sensitive and specific tumour marker to differentiate OSCC cases from controls. It is cost effective and minimally invasive, making it a potentially useful adjunct diagnostic tool in a high-risk patient pool. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.729-735

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Di Spirito, Federica, Giuseppe Pantaleo, Maria Pia Di Palo, Alessandra Amato, Annunziata Raimondo, and Massimo Amato. "Oral Human Papillomavirus Benign Lesions and HPV-Related Cancer in Healthy Children: A Systematic Review." Cancers 15, no. 4 (February 8, 2023): 1096. http://dx.doi.org/10.3390/cancers15041096.

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The present systematic review aimed to assess the prevalence of oral HPV-related lesions, categorized as benign (verruca vulgaris “VV”, squamous cell papilloma “SP”, condyloma acuminata “CA”, and focal epithelial hyperplasia “FEH”) and malignant (oral squamous cell carcinoma “OSCC”), in descending order of occurrence in pediatric subjects (≤18 years of age). The secondary objectives were to evaluate the frequency and types of oral lesions described in relation to HPV genotypes and the HPV vaccine type (if any). The study protocol, compliant with the PRISMA statement, was registered at PROSPERO (CRD42022352268). Data from 60 studies, of which quality was assessed using the ROBINS-I tool, were independently extracted and synthesized. Along with seven poorly described benign HPV-related oral lesions that could not be categorized, a total of 146 HPV-related oral lesions, namely 47.26% (n = 69) VV, SP, and CA, 51.37% (n = 75) FEH, and 1.37% (n = 2) OSSC, were diagnosed in 153 pediatric subjects (M:F ratio = 1:1.4) with a mean age of lesion onset of 8.46 years. The viral genotypes detected were HPV-13 (30.61%), -6 (20.41%), -11 (16.33%), HPV-2 (12.24%), -32 (10.20%), -57 (6.12%), and -16 (4.08%). No HPV vaccination was reported in any case. Further studies should be conducted to evaluate the prevalence of HPV-related benign and malignant lesions and the potential role of HPV and associated vaccination in oral carcinogenesis in pediatric subjects.

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Monteiro Júnior, Marcelo José, Fernando Araujo Crescencio, and Neil Franco. "Ginástica para Todos na Educação Infantil." LICERE - Revista do Programa de Pós-graduação Interdisciplinar em Estudos do Lazer 25, no. 3 (November 14, 2022): 129–54. http://dx.doi.org/10.35699/2447-6218.2022.41685.

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Compreendemos os significados elaborados por crianças participantes do projeto Ginástica Para Todos (GPT) na Obra Social Santa Catarina (OSSC) em relação ao processo de vivência da prática de GPT na construção coreográfica e sua apresentação. Metodologicamente, utilizamos de fontes bibliográficas, documentais, observação participante, roda de conversa e entrevista, situando-nos, assim, no universo de uma pesquisa participante e de abordagem qualitativa. Ancoramo-nos em referenciais específicos da área da Educação Física escolar com um forte viés na abordagem crítico-superadora. Ocorreram diversos benefícios no processo, englobando desde a divulgação da GPT como conteúdo escolar, até a contribuição para a formação docente, enriquecendo nossa experiência como futuros professores.

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Kaur, Mandeep, and Mayank Virmani. "Squamous Cell Carcinoma of Left Lateral Border of Tongue followed by Therapy Induced Mucositis Grade 4." Journal of Clinical Case Reports & Studies 3, no. 9 (November 26, 2022): 01–05. http://dx.doi.org/10.31579/2690-8808/133.

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Carcinomas are the major serious health issue in today’s healthcare system. while its prognosis is difficult at earlier stages. OSSC oral squamous cell carcinomas are reported more than 3 lakhs new cases world-wide and it is sixth most common cancer world-wide. Squamous cell carcinoma is defined as the cancer of soft, flat, thin squamous cells mainly affect the soft cell regions like tongue diagnosed by various investigational imaging and biochemistry parameters. In this case patient was diagnosed with High Grade Squamous Cell Carcinoma. Radiation therapy along with chemotherapy is the option for better therapeutic outcomes. Hence, EBRT therapy is given and in 2 gray every cycle and a total of 59.8 gray, 20 cycle therapy depending on condition of patient. In 90% cases radiation therapy leads to RIOM (Radiation Induced Oral Mucositis) which is totally unprotectable and there in no specific treatment option available in market approved by US-FDA yet. RIOM is diagnosed by WHO grading system based on the parameters and observations. In this condition patient suffers from inflammation, mouth ulcers and progressive condition and patient can not be able to swallow anything. It’s five stage process which treated by giving antibiotic in case of RIOM and oral hygenine, mouthpaints are advised. Levofloxaccin 750mg with clotrimazole mouthpaint was given to the patient. Radiation therapy continued with curative and Supportive therapy and was successful radiation therapy also shows good response and reduction in growth of tumor was observed and therapeutic goals were achieved.

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Destino, Vincenzo, Nicola Pedroni, Roberto Bonifetto, Francesco Di Maio, Laura Savoldi, and Enrico Zio. "Metamodeling and On-Line Clustering for Loss-of-Flow Accident Precursors Identification in a Superconducting Magnet Cryogenic Cooling Circuit." Energies 14, no. 17 (September 5, 2021): 5552. http://dx.doi.org/10.3390/en14175552.

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In the International Thermonuclear Experimental Reactor, plasma is magnetically confined with Superconductive Magnets (SMs) that must be maintained at the cryogenic temperature of 4.5 K by one or more Superconducting Magnet Cryogenic Cooling Circuits (SMCCC). To guarantee cooling, Loss-of-Flow Accidents (LOFAs) in the SMCCC are to be avoided. In this work, we develop a three-step methodology for the prompt detection of LOFA precursors (i.e., those combinations of component failures causing a LOFA). First, we randomly generate accident scenarios by Monte Carlo sampling of the failures of typical SMCCC components and simulate the corresponding transient system response by a deterministic thermal-hydraulic code. In this phase, we also employ quick-running Proper Orthogonal Decomposition (POD)-based Kriging metamodels, adaptively trained to reproduce the output of the long-running code, to decrease the computational time. Second, we group the generated scenarios by a Spectral Clustering (SC) employing the Fuzzy C-Means (FCM), in order to identify the main patterns of system evolution towards abnormal states (e.g., a LOFA). Third, we develop an On-line Supervised Spectral Clustering (OSSC) technique to associate time-varying parameters measured during plant functioning to one of the prototypical groups obtained, which may highlight the related LOFA precursors (in terms of SMCCC components failures). We apply the proposed technique to the simplified model of a cryogenic cooling circuit of a single module of the ITER Central Solenoid Magnet (CSM). The framework developed promptly detects 95% of LOFA events and around 80% of the related precursors.

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Rakheerathnam, K. K., K. Ranganathan, and S. Niranjali Devaraj. "Cross-talk of TGF-β and Wnt/β-Catenin Pathways Leading to Epithelial Mesenchymal Transition in Oral Submucous Fibrosis in Indian Population." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 203s. http://dx.doi.org/10.1200/jgo.18.82100.

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Background: Oral squamous cell carcinoma (OSCC) is a predominant type of cancer in India. It has been observed that OSSC is preceded by premalignant lesions or otherwise reported as potentially malignant disorders (PMD) by WHO during the year 2005. PMD include various oral mucosal diseases such as leukoplakia, erythroplakia, oral submucous fibrosis (OSMF), oral lichen planus, discoid lupus erythematosus and actinic keratosis etc. Literature surveys have highlighted that areca nut–associated oral squamous cell carcinoma is the third most common malignancy in the developing world and OSMF has been reported as the PMD of the oral cavity that has high prevalence rate in India. Since the exact mechanism behind this fibrosis condition is yet to be identified, we propose that, components in areca nut could interfere with certain signaling pathways in the human system that could lead to this precancerous stage. Aim: 1. To investigate the molecular mechanism involved in EMT by cross-talk between TGF-β and Wnt/β-catenin pathways in OSMF patients. 2. To explore the role of HSP90 inhibition in this cross-talk under hypoxic condition. Methods: OSMF tissue samples were obtained via punch biopsy, from patients with areca nut chewing habit and control tissues were collected from healthy individuals. OSMF patients who underwent any local treatment of oral mucosa or those who have any systemic disorder were excluded from the study. Initially, the expression pattern of various TGF-β and Wnt signaling pathway molecules were studied immunohistochemically to confirm the role of these pathways in OSMF. The gene expression of Wnt5a, Wnt3a, GSK-3β, β-catenin, cMyc, TGFβ1, smad3, E-cadherin, snail, α-SMA and Twist were studied by quantitative real time PCR (qRT-PCR). The results of qRT- PCR were further confirmed by Western blot analysis. Human gingival derived fibroblast cells were cultured and the cells were grouped into 2. Group I- normoxia, group II- hypoxia, group III- hypoxia + 17-AAG (an inhibitor of HSP90). mRNA and protein expression patterns were revealed by qRT-PCR and Western blot analysis for HSP90, HIF-1α, Wnt5a, β-catenin, cMyc, TGF-β1, Smad3, p-Smad3, E-cadherin, N-cadherin, Snail and α-SMA. Immunofluorescence analysis of expression of HSP90, HIF-1α, vimentin, snail, TGF-β1, Smad3 were also carried out. Results: The results obtained revealed that, TGF-β and Wnt/β-Catenin signaling molecules are involved in OSMF leading to EMT. The same pattern was observed when the cells were maintained under hypoxic conditions. Conclusion: Overall, this study describes the cross-talk of TGF-β and Wnt/β-Catenin pathways in EMT in tissues collected from OSMF patients and also when the cells were maintained under normoxic and hypoxic conditions. Inhibition of this signaling cross-talk might help to identify a new strategy for therapeutic intervention.

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Holmes, Haly Karen, Amir Afrogeh, Henry Adeola, Faheema Kimmie-Dhansay, and Mark E. Engel. "Prevalence and distribution of HPV infection and subtypes in oral squamous cell carcinoma in Africa: a systematic review protocol." BMJ Open 11, no. 7 (July 2021): e049922. http://dx.doi.org/10.1136/bmjopen-2021-049922.

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IntroductionHuman papillomavirus (HPV) is an established risk factor for oropharyngeal squamous cell carcinoma, regardless of a history of other known risk factors such as alcohol and tobacco. While cases of HPV-related oral squamous cell carcinoma (OSSC) are increasing in the USA, Europe and South Central Asian countries, little is known about the impact of the disease on the African continent.Methods and analysisWe describe a protocol for a systematic review to synthesise the best current evidence to assess the disease burden in Africa. Electronic databases including EBSCOhost, MEDLINE, CINAHL, ACADEMIC SEARCH COMPLETE, ScienceDirect, Web of Science, Scopus, SciCENTRAL, Cochrane Library, International Prospective Register of Systematic Reviews) and WorldCAT will be comprehensively searched for studies reporting on the defined outcomes, in Africa, published from 1985 (when HPV was first reported) to the latest current entries, with no language restriction. Supplemental handsearching of grey literature, conference abstract proceedings, reference lists of included studies and citations in Google Scholar will be conducted. Authors will be contacted, where necessary, to assist with missing data. A customised data extraction form, with specified criteria, will be used for data extraction. Overall study quality assessment will be done using an appropriate risk of bias tool suited to the study design. Where available, qualitative data from studies reporting on the outcomes will be captured on the data extraction form. Using Stata software, we will apply the random-effects meta-analysis model to aggregate prevalence estimates with 95% CI, incorporating the Freeman-Tukey transformation to account for between-study variability. A narrative report of the findings will be presented where data are insufficient in terms of the outcome/s. Subgroup analysis will be done subject to sufficient available data.Ethics and disseminationEthics approval or written consent is not required as the review will be conducted using published data. The findings will be distributed through a peer-review publication and conference presentation.

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De Seta, D., P. Mancini, F. Y. Russo, R. Torres, I. Mosnier, J. L. Bensimon, E. De Seta, et al. "Ricostruzione multiplanare 3D di immagini cone beam per lidenficazione della posizione degli impianti cocleari. Studio su ossi temporali e pazienti impiantati." Acta Otorhinolaryngologica Italica 36, no. 6 (December 2016): 499–505. http://dx.doi.org/10.14639/0392-100x-1279.

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Questo studio riporta unanalisi retrospettica delle immagini cone beam CT effettuate su 8 pazienti adulti sottoposti ad impianto cochleare MedEl flex 28 e su 14 ossi temporali impiantati con lo stesso tipo di array portaelettrodi. Lo scopo dello studio é di determinare laffidabilità della metodica cone beam CT nella valutazione della posizione intracocleare degli elettrodi in impianti che si posizionano lungo la parete laterale del lume cocleare, quindi non perimodiolari la cui posizione é più facilmente identificabile. Un otoradiologo e due otologi hanno analizzato le immagini e assegnato la posizione per ciascun elettrodo localizzato nella regione dei 180° e dei 360° del primo giro cocleare e per lelettrodo apicale scegliendo tra scala timpanica, vestibulare o posizione intermedia Lanalisi istologica ha successivamente confermato lesatta posizione negli ossi temporali. Nel gruppo dei pazienti per lelettrodo a 180° i tre esperti concordavano sulla posizione in scala timpanica in tutti eccetto un paziente, mentre una discordanza nella valutazione era presente in 3 pazienti per gli elettrodi a 360° e per gli elettrodi apicali. Negli ossi temporali in 5 casi era presente una discordanza per lelettrodo a 180°, mentre a 360° sei valutazioni erano discordanti tra i valutatori. Una disdcordanza tra le valutazioni più elevata veniva trovata per la la posizione dellelettrodo apicale (concordanza valutatori 45.4%, Fleiss k = 0,13). Un buon grado di concordanza veniva trovato tra i risultati istologici e le valutazioni tra i valutatori per gli elettrodi localizzati nel giro basale; un grado più basso esisteva per la posizione degli elettrodi apicali (concordanza valutatori 50%, Cohens k = 0,31) confermando la difficoltà nella corretta valutazione della posizione degli elettrodi nella regione più apicale negli ossi temporali. In conclusione, le immagini cone beam postoperatorie analizzate con la metodica della ricostruzione multiplanare 3D rappresentano una metodica affidabile per lo studio della posizione intracocleare degli elettrodi a posizionamento laterale nei pazienti impiantati. La corretta identificazione del posizionamento dellelettrodo piu apicale risulta difficile su osso temporale per la presenza di un artefatto più importante o per la minore resistenza delle strutture della parete laterale della coclea (legamento spirale, membrane basilare) nel preparato istologico (osso temporale fresco/congelato) che è responsabile di un maggior numero di traslocazioni dalla rampa timpanica alla rampa vestibolare e di localizzazioni intermedie più difficilmente interpretabili.

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Schiavone, Francesco, and Stefano Borzillo. "Creating technological knowledge in vintage communities of practice." Journal of Knowledge Management 18, no. 5 (September 2, 2014): 991–1003. http://dx.doi.org/10.1108/jkm-06-2014-0251.

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Purpose – The purpose of this paper is to show how members of a “vintage community of practice” (CoP) – the Multiple Arcade Machine Emulator (MAME) community – recombine old technological knowledge with new technological knowledge. A vintage CoP is a group of aficionados of old technology who keep using it even after superior new technologies have emerged and technological change has taken place. This paper presents mechanisms through which developers and gamers in the MAME community and its subcommunities or hubs select and recombine old and new technology to update old arcade videogames in a format that is playable on current personal computers (PCs). Design/methodological approach – An inductive single-case exploratory case study was conducted in the MAME community. Semi-structured interviews were conducted with core community members to uncover mechanisms through which old technology-related knowledge (T-RK) was combined with new T-RK to update old versions of arcade video games into software versions that can be played on current PCs. Informant discourses were analyzed using first- and second-order coding methods. Findings – Our data revealed three mechanisms through which community leaders positively impact new and old T-RK recombinations that led to new knowledge creation within the MAME vintage CoP. We named these mechanisms leader mentorship, leader self-development propensity and clustering in the community. Our data also revealed a two-phase knowledge creation process in an open-source software community (OSSC) that supports the MAME community: knowledge selection and knowledge recombination. Research limitations/implications – The study is limited by the size of the investigated community, so further research should be conducted in multiple vintage CoPs so as to generalize our results. Practical implications – Our results offer practitioners insights into the internal knowledge creation mechanisms that occur in vintage CoPs. Our findings seek to motivate managers to start collaborating with vintage CoPs to develop products for the niche vintage product markets. Originality/value – This research is one of the first in the field of vintage communities of practice. It affords understanding of social mechanisms by which old technologies are combined with new ones to give rise to vintage products that suit the needs of niche vintage product markets.

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Knight, Bernard. "Ossa reperta." Journal of the Forensic Science Society 25, no. 1 (January 1985): 83–84. http://dx.doi.org/10.1016/s0015-7368(85)72367-5.

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Bruera, Gemma, Silvia Massacese, Francesco Pepe, Umberto Malapelle, Antonella Dal Mas, Eugenio Ciacco, Giuseppe Calvisi, Giancarlo Troncone, Maurizio Simmaco, and Enrico Ricevuto. "Intensive first-line FIr-C/FOx-C association of triplet chemotherapy plus cetuximab in RAS wild-type metastatic colorectal cancer patients: preliminary phase II data and prediction of individual limiting toxicity syndromes by pharmacogenomic biomarkers." Therapeutic Advances in Medical Oncology 11 (January 2019): 175883591984642. http://dx.doi.org/10.1177/1758835919846421.

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Background: Intensive triplet chemotherapy/bevacizumab significantly increased metastatic colorectal cancer (MCRC) outcome. This phase II study investigated the safety/activity of FIr-C/FOx-C triplet/cetuximab (CET) in first-line RAS wild-type and the prediction of individual limiting toxicity syndromes (LTS) by pharmacogenomic biomarkers. Methods: A Simon two-step design was used: p0 70%, p1 85%, power 80%, α5%, β20%; projected objective response rate (ORR) I step 14/19. FIr-C/FOx-C: 5-fluorouracil (5-FU) 12h-timed flat infusion 900 mg/m2 d1–2, 8–9, 15–16, 22–23; irinotecan (CPT-11) 160 mg/m2 d1 and 15, oxaliplatin 80 mg/m2 d8 and 22; CET 400mg/m2 then 250 mg/m2 d1, 8, 15, 22; every 28 days. Toxicity, and individual LTS were evaluated, compared by a Chi-square test; and activity/efficacy by log-rank. 5-FU/CPT-11 pharmacogenomic biomarkers, 5-FU degradation rate (5-FUDR), single nucleotide polymorphisms (SNPs) ABCB1, CYP3A4, DYPD, UGT1A1 were evaluated in patients with LTS and at a recommended dose. Results: A total of 29 patients <75 years, with a primary/intermediate Cumulative Index Rating Scale were enrolled; the median age was 59 years; there were 7 young-elderly (yE; 24%). Recommended CPT-11/5-FU doses were 120/750 mg/m2. In the intent-to-treat analysis, the ORR was 58.6%. The primary endpoint was met in patients who received the planned three treatment cycles: the objective response (OR) was 14/18 (78%). At a median follow up of 18 months, progression-free survival (PFS) was 12, and overall survival (OS) was 23 months. At the recommended doses (received dose intensity >80%), grade 3–4 toxicities were: diarrhea 23%, asthenia 15%, vomiting 8%, hypertransaminasemy 8%; LTS 19 (65.5%), with 83% in yE patients. LTS prevalently multiple (ms) versus single site were 59% versus 7% ( p = 0.006). The prevalence of reduced FUDR was 56%, SNPs CYP3A4 22%, UGT1A1 71%, and of >2 positive pharmacogenomics biomarkers was 78%, prevalently reported in patients who developed gastrointestinal LTS. Conclusions: FIr-C/FOx-C is highly active and tolerable at recommended doses in non-elderly RAS wild-type MCRC patients. LTS provided an evaluation of the toxicity burden in individual patients. Reduced FUDR, CYP3A4, and UGT1A1 SNPs may predict individual LTS-ms in patients at risk of limiting gastrointestinal toxicity. Trial registration: The trial was registered at Osservatorio Nazionale sulla Sperimentazione Clinica dei Medicinali (OsSC) Agenzia Italiana del Farmaco (AIFA) Numero EudraCT 2009-016793-32.

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Saraux, A., and Y. Guillodo. "Sport e osso." EMC - AKOS - Trattato di Medicina 13, no. 2 (January 2011): 1–5. http://dx.doi.org/10.1016/s1634-7358(11)70615-5.

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Greco, Emanuela A., Rachele Fornari, Andrea Lenzi, and Silvia Migliaccio. "Osso e infiammazione." L'Endocrinologo 16, no. 2 (April 2015): 51–56. http://dx.doi.org/10.1007/s40619-015-0101-x.

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Sakamoto, Leonardo. "Carne e Osso." Revista Pedagógica 15, no. 30 (August 21, 2013): 699. http://dx.doi.org/10.22196/rp.v15i30.1588.

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NAUMANN, C. F. "III. Ossa tendinum." Nordiskt Medicinskt Arkiv 16, no. 20 (April 24, 2009): 13–15. http://dx.doi.org/10.1111/j.0954-6820.1884.tb00140.x.

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Alvarez-Rodríguez, Jose María, Juan Llorens, Manuela Alejandres, and Jose Miguel Fuentes. "OSLC-KM: A knowledge management specification for OSLC-based resources." INCOSE International Symposium 25, no. 1 (October 2015): 16–34. http://dx.doi.org/10.1002/j.2334-5837.2015.00046.x.

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Préat, Alain, and Francis Weber. "Comment on Ossa Ossa et al. (2018) paper published in EPSL." Earth and Planetary Science Letters 511 (April 2019): 256–58. http://dx.doi.org/10.1016/j.epsl.2019.01.017.

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Trapp, Annie. "Heaping Pelion on Ossa." Psychology Learning & Teaching 8, no. 2 (January 1, 2009): 5–6. http://dx.doi.org/10.2304/plat.2009.8.2.5.

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Montante, Michela, and Giovanni Testori. "Ossa mea (1981-1982)." World Literature Today 59, no. 1 (1985): 74. http://dx.doi.org/10.2307/40140599.

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Thomsen, Hans Jørgen. "Jeg tænker... satans osse." Slagmark - Tidsskrift for idéhistorie, no. 27 (February 4, 2018): 165–68. http://dx.doi.org/10.7146/sl.v0i27.103886.

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Chesterman, Andrew. "Ossi Ihalainen - 1941 — 1993." English World-Wide 15, no. 1 (January 1, 1994): 128–30. http://dx.doi.org/10.1075/eww.15.1.09che.

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Orchard, A., F. Shah, and S. Prabhu. "Diagnosing OSCC via video." British Dental Journal 228, no. 12 (June 2020): 903–4. http://dx.doi.org/10.1038/s41415-020-1802-5.

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Colaianni, G., T. Mongelli, S. Colucci, S. Cinti, and M. Grano. "Irisina, osso e muscolo." L'Endocrinologo 17, no. 4 (August 2016): 199–202. http://dx.doi.org/10.1007/s40619-016-0222-x.

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Elkins, M. "Five Years of OSSG." ITNOW 53, no. 1 (December 23, 2010): 23. http://dx.doi.org/10.1093/itnow/bwq231.

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McNaron-Brown, K., W. N. Johnson, G. V. Jung, R. L. Kinzer, J. D. Kurfess, M. S. Strickman, C. D. Dermer, et al. "OSSE Observations of Blazars." Astrophysical Journal 451 (October 1995): 575. http://dx.doi.org/10.1086/176245.

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Anonymous. "OSSA queues space projects." Eos, Transactions American Geophysical Union 69, no. 21 (1988): 610. http://dx.doi.org/10.1029/88eo00184.

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Noyes, Frank R., and Sue D. Barber-Westin. "Revisão da Cirurgia Cruciforme Anterior com Enxertos Autógenos Osso-Tendão Osso-Patelar." Journal of Bone and Joint Surgery-American Volume 83, no. 8 (August 2001): Adv 16. http://dx.doi.org/10.2106/00004623-200108000-00044.

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Visioli, Fernanda, Julia Silveira Nunes, Maria Carmela Pedicillo, Rosalia Leonardi, Angela Santoro, Gian Franco Zannoni, Gabriella Aquino, et al. "TLR4 Expression in Ex-Lichenoid Lesions—Oral Squamous Cell Carcinomas and Its Surrounding Epithelium: The Role of Tumor Inflammatory Microenvironment." Biomolecules 12, no. 3 (February 28, 2022): 385. http://dx.doi.org/10.3390/biom12030385.

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Toll-like receptors (TLRs) regulate innate and adaptive immune responses. Moreover, TLRs can induce a pro-survival and pro-proliferation response in tumor cells. This study aims to investigate the expression of TLR4 in the epithelium surrounding oral squamous cell carcinomas (OSCC) in relation to its inflammatory microenvironment. This study included 150 human samples: 30 normal oral control (NOC), 38 non-lichenoid epithelium surrounding OSCC (NLE-OSCC), 28 lichenoid epithelium surrounding OSCC (LE-OSCC), 30 OSCC ex-non oral lichenoid lesion (OSCC Ex-NOLL), and 24 OSCC ex-oral lichenoid lesion (OSCC Ex-OLL). TLR4 expression was investigated by immunohistochemistry and the percentage of positive cells was quantified. In addition, a semiquantitative analysis of staining intensity was performed. Immunohistochemical analysis revealed that TLR4 is strongly upregulated in LE-OSCC as compared to normal control epithelium and NLE-OSCC. TLR4 expression was associated with the inflammatory environment, since the percentage of positive cells increases from NOC and NLE-OSCC to LE-OSCC, reaching the highest value in OSCC Ex–OLL. TLR4 was detected in the basal third of the epithelium in NLE-OSCC, while in LE-OSCC, TLR4 expression reached the intermediate layer. These results demonstrated that an inflammatory microenvironment can upregulate TLR4, which may boost tumor development.

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Zaidi, Sana Jafar, Nabeela Riaz, Asifa Iqbal, and Ayyaz Ali Khan. "Salivary Matrix Metalloproteinase (MMP)-1 as Non-Invasive Tool for The Diagnosis of Oral Squamous Cell Carcinoma (OSCC)." Journal of the Pakistan Dental Association 30, no. 1 (February 14, 2021): 18–23. http://dx.doi.org/10.25301/jpda.301.18.

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OBJECTIVE: To determine the diagnostic accuracy of salivary MMP1 as non-invasive diagnostic biomarker of OSCC through conventional sandwich ELISA technique. Analytical cross-sectional study. METHODOLOGY: Individuals with clinical suspicion for OSCC (IWCS-OSCC) were included in the study after fulfilling selection criteria. Saliva samples were collected from IWCS-OSCC. To confirm OSCC, the patients were referred for biopsy. After definitive diagnosis on biopsy, patients were labeled OSCC positive or OSCC negative. The colorimetric sandwich-ELISA test was performed on saliva samples to measure the level of MMP1. Data was entered in "Statistical Package for the Social Sciences (SPSS) -16" and levels of MMP1 were correlated with the biopsy status of patient (OSCC positive or OSCC negative). RESULTS: Our sample included twice as many males as females (2.1:1) and a wide age range of 22-77years with median age of 50yrs. Of all the IWCS-OSCC 85% were OSCC +ve and 15% were OSCC-ve. Diagnostic accuracy was measured as; Area under curve (AUC) = 0.623, Sensitivity (Sn) = 50%, Specificity (Sp)= 83.3%, Positive predictive value (PPV)= 94.4%, Negative predictive value (NPV)= 22.7% CONCLUSION: MMP1 as detected by conventional sandwich-ELISA technique is not proven as an accurate diagnostic biomarker of OSCC. KEY WORDS: OSCC; MMP1; IWCS-OSCC; Sandwich-ELISA HOW TO CITE: Zaidi SJ, Riaz N, Iqbal A, Khan AA. Salivary matrix metalloproteinase (MMP)-1 as non-invasive tool for the diagnosis of oral squamous cell carcinoma (OSCC). J Pak Dent Assoc 2021;30(1):18-23.

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Iwamura, Edna Sadayo Miazato. "Análise de DNA em osso humano: estudo qualitativo da microestrutura do osso compacto." Saúde, Ética & Justiça 8, no. 1-2 (November 7, 2003): 60. http://dx.doi.org/10.11606/issn.2317-2770.v8i1-2p60-61.

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Para a execução da etapa inicial da identificação médico-legal de restos humanos (antropometria e exame dos arcos dentários), faz-se necessária uma limpeza prévia da ossada, para a remoção de tecidos moles putrefeitos. Os casos não identificados por esses métodos tradicionais, poderão ser submetidos ao exame de DNA. No entanto, apesar do grande avanço da biologia molecular, utilizando a amplificação de DNA pela PCR, algumas limitações que afetam a habilidade de se obter DNA em restos humanos, permanecem. Dessa forma, o objetivo deste trabalho foi fornecer subsídios morfológicos para os analistas forenses, com ênfase na prática médico-legal, visando uma utilização mais eficiente do DNA obtido de osso compacto de restos humanos em decomposição ou já esqueletizados, sem tecidos moles aderidos. Foi realizado o estudo da microestrutura do tecido ósseo compacto femoral, de restos humanos em decomposição, ainda com tecidos moles, que foram limpos pela fervura em água (n = 7) e ossadas já esqueletizadas pela decomposição natural, que não foram fervidas (n = 8). Destes, seis ossadas foram provenientes de cemitério público regular, após 3 anos de inumação, 1 ossada proveniente da região amazônica, e 1 ossada de origem desconhecida. Estas duas ultimas, apresentado-se porosas ou quebradiças. As análises morfológicas de cortes histológicos foram coradas com hematoxilina e eosina e o DNA amplificado pela PCR para os loci CSF1PO, TPOX, TH01, F13A0, FESFPS, vWA, D16S539, D7S820, D13S317 e amelogenina. Os resultados da análise desses dois grupos foram comparados com os de cadáveres frescos (n = 5) do Serviço de Verificação de Óbitos da Capital. A fervura dos ossos, do modo como é realizada no Instituto Médico Legal de São Paulo, pode aumentar a eosinofilia da matriz óssea e, em alguns casos, pode promover a desagregação dos ósteons. Tal procedimento pode remover células, mas pode também remover possíveis inibidores da PCR, favorecendo a análise do DNA obtido destas amostras. O fator limitante para a obtenção e análise de DNA, em amostras de ossos limpos por fervura, é a quantidade exígua de células. Ossos não submetidos à fervura, após inumação por três anos ou há mais tempo em contato com a terra, podem apresentar alterações da microestrutura. No entanto, a presença de hemácias preservadas e núcleos de osteócitos nestas amostras, indica melhor preservação de células em relação às amostras de ossos fervidos. O fator limitante para a análise de DNA nestas amostras é a presença sugestiva de inibidores da reação de amplificação pela PCR. Restos humanos, sem tecidos moles, macroscópicamente não preservados (porosos e quebradiços), e não submetidos à fervura, apresentam alterações de perda de matriz mineralizada; no entanto, nestas amostras ainda é possível encontrar células preservadas. Os resultados obtidos no neste trabalho permitem traçar algumas estratégias para uma melhor utilização nos protocolos de extração e análise do DNA em osso compacto de restos humanos.

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Yu, Huijie, Tianhua Li, and Xuemei Mao. "Expression and Significance of Sex-Determining Region Y (SRY)–Box 12 (SOX12) in Oral Squamous Cell Carcinoma." Journal of Biomaterials and Tissue Engineering 12, no. 10 (October 1, 2022): 2074–79. http://dx.doi.org/10.1166/jbt.2022.3147.

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Oral squamous cell carcinoma (OSCC) is a ubiquitous malignancy and is associated with high mortality. Accumulating evidence indicates that transcription factors play a pivotal role in the progression of OSCC. This study was aimed to investigate the expression of SOX12 in OSCC and its significance. SOX12 expression in OSCC tissues was analyzed through TCGA databases and then tested by Western blot and qRT-PCR analysis. Moreover, SOX12 was silenced by RNA interference in OSCC cells (SCC-25 and SCC-4), and the growth ability of OSCC cells was examined using MTT assay. The level of SOX12 was upregulated in OSCC according to the TCGA results, which was further confirmed in the OSCC cell lines. Patients with high SOX12 expression had shorter overall survival (OS) than those with low SOX12 expression. High expression of SOX12 is positively correlated with T stage of OSCC. In addition, MTT analysis indicated that silencing of SOX12 resulted in reduced OSCC cell proliferation. Taken together, the high expression of SOX12 in OSCC indicates that SOX12 gene may play an essential role in OSCC. Our research indicates that SOX12 expression could be a predictive biomarker and is a potential therapeutic target for OSCC.

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Lin, Yi-Chung, and Bor-Sen Chen. "Identifying Drug Targets of Oral Squamous Cell Carcinoma through a Systems Biology Method and Genome-Wide Microarray Data for Drug Discovery by Deep Learning and Drug Design Specifications." International Journal of Molecular Sciences 23, no. 18 (September 8, 2022): 10409. http://dx.doi.org/10.3390/ijms231810409.

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In this study, we provide a systems biology method to investigate the carcinogenic mechanism of oral squamous cell carcinoma (OSCC) in order to identify some important biomarkers as drug targets. Further, a systematic drug discovery method with a deep neural network (DNN)-based drug–target interaction (DTI) model and drug design specifications is proposed to design a potential multiple-molecule drug for the medical treatment of OSCC before clinical trials. First, we use big database mining to construct the candidate genome-wide genetic and epigenetic network (GWGEN) including a protein–protein interaction network (PPIN) and a gene regulatory network (GRN) for OSCC and non-OSCC. In the next step, real GWGENs are identified for OSCC and non-OSCC by system identification and system order detection methods based on the OSCC and non-OSCC microarray data, respectively. Then, the principal network projection (PNP) method was used to extract core GWGENs of OSCC and non-OSCC from real GWGENs of OSCC and non-OSCC, respectively. Afterward, core signaling pathways were constructed through the annotation of KEGG pathways, and then the carcinogenic mechanism of OSCC was investigated by comparing the core signal pathways and their downstream abnormal cellular functions of OSCC and non-OSCC. Consequently, HES1, TCF, NF-κB and SP1 are identified as significant biomarkers of OSCC. In order to discover multiple molecular drugs for these significant biomarkers (drug targets) of the carcinogenic mechanism of OSCC, we trained a DNN-based drug–target interaction (DTI) model by DTI databases to predict candidate drugs for these significant biomarkers. Finally, drug design specifications such as adequate drug regulation ability, low toxicity and high sensitivity are employed to filter out the appropriate molecular drugs metformin, gefitinib and gallic-acid to combine as a potential multiple-molecule drug for the therapeutic treatment of OSCC.

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Jobe, Dean A., Steven D. Lovrich, Ronald F. Schell, and Steven M. Callister. "C-Terminal Region of Outer Surface Protein C Binds Borreliacidal Antibodies in Sera from Patients with Lyme Disease." Clinical Diagnostic Laboratory Immunology 10, no. 4 (July 2003): 573–78. http://dx.doi.org/10.1128/cdli.10.4.573-578.2003.

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ABSTRACT Borreliacidal antibodies specific for outer surface protein C (OspC) are induced shortly after infection with Borrelia burgdorferi. In this study, we identified the region of OspC recognized by immunoglobulin M (IgM) and IgG borreliacidal antibodies. Sera from patients with early Lyme disease were screened for borreliacidal activity specific for B. burgdorferi 50772 and OspC antibodies. Seven sera that contained similarly high titers of each response were then chosen randomly and adsorbed with OspC or a truncated OspC (OspC-Dra) containing the 50 amino acids nearest the carboxy terminus. Adsorption with OspC or OspC-Dra completely eliminated the borreliacidal activity in six (86%) of seven sera and significantly decreased the activity in the remaining serum (titer of 10,240 to 1,280). Moreover, OspC antibodies were no longer detected by OspC enzyme-linked immunosorbent assay or in a Western blot that contained native OspC. The findings confirmed that sera from patients with early Lyme disease contain high concentrations of IgM or IgG borreliacidal antibodies that bind a conserved region of OspC.

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Journal articles on the topic 'OSSC'

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