Relevant bibliographies by topics / Orthopedic implants – Biocompatibility

Academic literature on the topic 'Orthopedic implants – Biocompatibility'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Orthopedic implants – Biocompatibility.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Orthopedic implants – Biocompatibility"

1

Nasakina, E. O., M. A. Sevostyanov, and A. G. Kolmakov. "Surface Modification of Orthopedic Implants Based on Titanium Alloys." Biotekhnologiya 36, no. 5 (2020): 31–40. http://dx.doi.org/10.21519/0234-2758-2020-36-5-31-40.

Full text
Abstract:
This review is devoted to modern technologies for various modifications of a surface of orthopedic implants made from titanium alloys. This approach will allow improving such characteristics of the implants as a corrosion resistance, biocompatibility and osteointegration. Modifications of titanium alloys with hydroxyapatite and calcium phosphate, multifunctional polymer or antibacterial coatings are considered. Analysis of the studies shows that the implant material can only provide a certain degree of biocompatibility and corrosion resistance, and that the nature and design of its surface have a strong influence on the body's response. Surface modification of implants is a good approach to overcome and solve various problems associated with the disadvantages of titanium alloys for orthopedic implants. titanium alloys, orthopedic implant, functional coating, ceramic coating, polymer coating, antibacterial coating The reported study was funded by RFBR, project No 19-18-50015.
APA, Harvard, Vancouver, ISO, and other styles
2

Bai, Gong, Chen, Sun, Zhang, Cai, Zhu, and Xie. "Additive Manufacturing of Customized Metallic Orthopedic Implants: Materials, Structures, and Surface Modifications." Metals 9, no. 9 (September 12, 2019): 1004. http://dx.doi.org/10.3390/met9091004.

Full text
Abstract:
Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients has become a trend of various bone defect repair. A superior customized implant should have good biocompatibility and mechanical properties matching the defect bone. To meet the performance requirements of implants, this paper introduces the biomedical metallic materials currently applied to orthopedic implants from the design to manufacture, elaborates the structure design and surface modification of the orthopedic implant. By selecting the appropriate implant material and processing method, optimizing the implant structure and modifying the surface can ensure the performance requirements of the implant. Finally, this paper discusses the future development trend of the orthopedic implant.
APA, Harvard, Vancouver, ISO, and other styles
3

Adam, Razvan, Horia Orban, Lavinia Dragomir, Claudia Milea, Iulian Antoniac, and Adrian Barbilian. "Investigation of Biodegradation Behavior of an Mg-1Ca Alloy during In Vivo Testing." Key Engineering Materials 752 (August 2017): 87–92. http://dx.doi.org/10.4028/www.scientific.net/kem.752.87.

Full text
Abstract:
In case of an orthopedic implant, it would be ideal that resorption to occur by biodegradation and bone remodeling. The main advantage of using resorbable orthopedic implants is eliminating the need for a new surgical procedure. The use of pure magnesium for orthopedic implants shows some drawbacks, which need to be considered and evaluated by in vitro and in vivo assays. One of the main problems encountered when pure Mg is used as biodegradable implant is represented by a high corrosion rate, faster than the rate of bone formation. The aim of this study is testing and evaluation of Mg-1Ca alloy from biocompatibility in vivo point of view. The purpose of in vivo test was to demonstrate good biocompatibility and lack of local and systemic toxicity of implants made by Mg-1Ca alloy. The study was conducted by implanting Mg-1Ca alloy parallelepiped shaped implants in the tibia of rabbits. In our tests related to Mg-1Ca alloy in vivo evaluation, there were no pathological increases in blood levels of Mg and Ca, or other elements, showing that it has no adversely affect to their metabolism. Also it shows a good bone integration, newly formed bone being adherent to the implant surface, with no tissue interposed between it and the bone. In conclusion, magnesium alloy Mg-1Ca represents a promising solution in orthopedic surgery, proving to be safe, with a high degree of biocompatibility and without toxic effects during in vivo testing.
APA, Harvard, Vancouver, ISO, and other styles
4

Zaman, Hainol Akbar, Safian Sharif, Mohd Hasbullah Idris, and Anisah Kamarudin. "Metallic Biomaterials for Medical Implant Applications: A Review." Applied Mechanics and Materials 735 (February 2015): 19–25. http://dx.doi.org/10.4028/www.scientific.net/amm.735.19.

Full text
Abstract:
Stainless steel, titanium alloys and cobalt chromium molybdenum alloys are classified under the metallic biomaterials whereby various surgical implants, prosthesis and medical devices are manufactured to replace missing body parts which may be lost through accident, trauma, disease, or congenital conditions. Among these materials, cobalt chromium molybdenum alloys are the common cobalt base alloy used for orthopedic implants due their excellence properties which include high corrosion resistance, high strength, high hardness, high creep resistance, biocompatibility and greater wear resistance. This paper summarises the various aspects and characteristic of metallic biomaterials such as stainless steel, titanium and cobalt chromium alloys for medical applications especially for orthopedic implant. These include material properties, biocompatibility, advantages and limitations for medical implants applications.
APA, Harvard, Vancouver, ISO, and other styles
5

Llopis-Grimalt, Maria Antonia, Aina Arbós, Maria Gil-Mir, Aleksandra Mosur, Prathamesh Kulkarni, Armando Salito, Joana M. Ramis, and Marta Monjo. "Multifunctional Properties of Quercitrin-Coated Porous Ti-6Al-4V Implants for Orthopaedic Applications Assessed In Vitro." Journal of Clinical Medicine 9, no. 3 (March 20, 2020): 855. http://dx.doi.org/10.3390/jcm9030855.

Full text
Abstract:
(1) One strategy to improve the outcome of orthopedic implants is to use porous implants with the addition of a coating with an antibacterial biomolecule. In this study, we aimed to produce and test the biocompatibility, the osteopromotive (both under normal conditions and under a bacterial challenge with lipopolysaccharide (LPS)) and antibacterial activities of a porous Ti-6Al-4V implant coated with the flavonoid quercitrin in vitro. (2) Porous Ti-6Al-4V implants were produced by 3D printing and further functionalized with quercitrin by wet chemistry. Implants were characterized in terms of porosity and mechanical testing, and the coating with quercitrin by fluorescence staining. Implant biocompatibility and bioactivity was tested using MC3T3-E1 preosteoblasts by analyzing cytotoxicity, cell adhesion, osteocalcin production, and alkaline phosphatase (ALP) activity under control and under bacterial challenging conditions using lipopolysaccharide (LPS). Finally, the antibacterial properties of the implants were studied using Staphylococcus epidermidis by measuring bacterial viability and adhesion. (3) Porous implants showed pore size of about 500 µm and a porosity of 52%. The coating was homogeneous over all the 3D surface and did not alter the mechanical properties of the Young modulus. Quercitrin-coated implants showed higher biocompatibility, cell adhesion, and osteocalcin production compared with control implants. Moreover, higher ALP activity was observed for the quercitrin group under both normal and bacterial challenging conditions. Finally, S. epidermidis live/dead ratio and adhesion after 4 h of incubation was lower on quercitrin implants compared with the control. (4) Quercitrin-functionalized porous Ti-6Al-4V implants present a great potential as an orthopedic porous implant that decreases bacterial adhesion and viability while promoting bone cell growth and differentiation.
APA, Harvard, Vancouver, ISO, and other styles
6

Arora, Himanshu, Anil Nafria, and Anup Kanase. "Rabbits as Animal Models in Contemporary Implant Biomaterial Research." World Journal of Dentistry 2, no. 2 (2011): 129–34. http://dx.doi.org/10.5005/jp-journals-10015-1069.

Full text
Abstract:
ABSTRACT Development of an optimal interface between bone and orthopedic or dental implants has taken place for many years. In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, mechanical stability and safety, it must undergo rigorous testing both in vitro and in vivo. Results from in vitro studies can be difficult to extrapolate to the in vivo situation. For this reason the use of animal models is often an essential step in the testing of orthopedic and dental implants prior to clinical use in humans. This review discusses the reasons, the importance, and the research carried out in rabbits in our quest to develop a dental implant ideally suited for human bone.
APA, Harvard, Vancouver, ISO, and other styles
7

Kwan, Millie, and Ri Zhi Wang. "Bio-Fabrication of Nacre on Conventional Implant Materials." Key Engineering Materials 529-530 (November 2012): 255–60. http://dx.doi.org/10.4028/www.scientific.net/kem.529-530.255.

Full text
Abstract:
Nacreous coatings on orthopedic implants can be advantageous because of its robust mechanical properties, high biocompatibility, and ability to promote bone growth. The biofabrication of nacreous coatings on conventional orthopedic implant materials via biomineralization process from abalone shells was examined. The objective was to investigate the effect of different materials on nacreous coating growth. The coatings were characterized by SEM/EDS and XRD. It was found that different materials resulted in different surface morphologies and coating thicknesses, although the main mineral formed was aragonite. Calcium carbonate coating was formed on the entire surface of the poly (methyl methacrylate) and high density polyethylene implants and resulted in a thick coating, while the titanium implants showed thinner coating at the same growing period.
APA, Harvard, Vancouver, ISO, and other styles
8

Noreen, Sehrish, Engui Wang, Hongqing Feng, and Zhou Li. "Functionalization of TiO2 for Better Performance as Orthopedic Implants." Materials 15, no. 19 (October 3, 2022): 6868. http://dx.doi.org/10.3390/ma15196868.

Full text
Abstract:
This review mainly focuses on the surface functionalization approaches of titanium dioxide (TiO2) to prevent bacterial infections and facilitate osteointegration simultaneously for titanium (Ti)-based orthopedic implants. Infection is one of the major causes of implant failure. Meanwhile, it is also critical for the bone-forming cells to integrate with the implant surface. TiO2 is the native oxide layer of Ti which has good biocompatibility as well as enriched physical, chemical, electronic, and photocatalytic properties. The formed nanostructures during fabrication and the enriched properties of TiO2 have enabled various functionalization methods to combat the micro-organisms and enhance the osteogenesis of Ti implants. This review encompasses the various modifications of TiO2 in aspects of topology, drug loading, and element incorporation, as well as the most recently developed electron transfer and electrical tuning approaches. Taken together, these approaches can endow Ti implants with better bactericidal and osteogenic abilities via the functionalization of TiO2.
APA, Harvard, Vancouver, ISO, and other styles
9

Shi, Yi Ping, Don Fang Yin, Ping Hu, Yi Fei Huang, and Lin Liu. "Synthesis and Biocompatibility Evaluation of Poly(HEMA-Co-MMA) Orbital Implant." Key Engineering Materials 288-289 (June 2005): 485–90. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.485.

Full text
Abstract:
Orbital implant, used for filling the space after enucleation, played an important role in the optical orthopedic operations. However, the clinical application of soft orbital implants was in a limited extent. This paper focused on the synthetic method of a new kind of soft poly (2-hydroxyethyl methacrylate) (PHEMA) orbital implant. This method included two steps, making the orbital implant with through-holes by salt leaking method and improving the compress property of PHEMA by copolymerizing it with methyl methacrylate (MMA). Scanning electronic microscope (SEM), thermo gravimetric analysis (TGA), and compress experiment were carried out to evaluate the physical properties of the implant. And to evaluate the biocompatibility of this poly (HEMA-co-MMA) orbital implant, short term and long term observations were studied after subcutaneous implantation of material blocks and implantation of orbital implants (diameter in 14mm) in rabbits’ orbits.
APA, Harvard, Vancouver, ISO, and other styles
10

Hussain, Muzamil, Syed Hasan Askari Rizvi, Naseem Abbas, Uzair Sajjad, Muhammad Rizwan Shad, Mohsin Ali Badshah, and Asif Iqbal Malik. "Recent Developments in Coatings for Orthopedic Metallic Implants." Coatings 11, no. 7 (June 30, 2021): 791. http://dx.doi.org/10.3390/coatings11070791.

Full text
Abstract:
Titanium, stainless steel, and CoCrMo alloys are the most widely used biomaterials for orthopedic applications. The most common causes of orthopedic implant failure after implantation are infections, inflammatory response, least corrosion resistance, mismatch in elastic modulus, stress shielding, and excessive wear. To address the problems associated with implant materials, different modifications related to design, materials, and surface have been developed. Among the different methods, coating is an effective method to improve the performance of implant materials. In this article, a comprehensive review of recent studies has been carried out to summarize the impact of coating materials on metallic implants. The antibacterial characteristics, biodegradability, biocompatibility, corrosion behavior, and mechanical properties for performance evaluation are briefly summarized. Different effective coating techniques, coating materials, and additives have been summarized. The results are useful to produce the coating with optimized properties.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Orthopedic implants – Biocompatibility"

1

Somayajula, Dilip Ayyala. "Biocompatibility of osteoblast cells on titanium implants." Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1207322725.

Full text
Abstract:
Thesis (M.S.)--Cleveland State University, 2008.
Abstract. Title from PDF t.p. (viewed on May 8, 2008). Includes bibliographical references (p. 72-76). Available online via the OhioLINK ETD Center. Also available in print.
APA, Harvard, Vancouver, ISO, and other styles
2

Yeung, Che-yan, and 楊芷茵. "Antibacterial properties and biocompatibility of novel peptide incorporated titanium alloy biomaterials for orthopaedic implants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hdl.handle.net/10722/197133.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Lin, Hsin-Yi. "Short term observations of in vitro biocorrosion of two commonly used implant alloys." Diss., Mississippi State : Mississippi State University, 2002. http://library.msstate.edu/etd/show.asp?etd=etd-08202002-105908.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Leung, Kit-ying, and 梁潔瑩. "Anti-bacteria plasma-treated metallic surface for orthopaedics use." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41633994.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Drago, Manuela Aleluia. "Placa de osso bovino na osteossíntese de tíbia de coelhos: avaliação biomecânica ex-vivo." Universidade Federal do Espírito Santo, 2011. http://repositorio.ufes.br/handle/10/5097.

Full text
Abstract:
Made available in DSpace on 2016-08-29T15:37:22Z (GMT). No. of bitstreams: 1 tese_5256_.pdf: 375211 bytes, checksum: 832eb7716f5f86a3d232c597e8e95ae1 (MD5) Previous issue date: 2011-09-06
O uso de materiais produzidos a partir de osso bovino tem sido proposto na confecção de implantes como pinos, placas e parafusos, por promoverem as mesmas funções de um enxerto ósseo, ou seja, serem osteoindutores e osteocondutores. Entretanto, aspectos estruturais e mecânicos devem ser estudados previamente ao uso in vivo de implantes de osso. Portanto, o objetivo desse estudo foi avaliar o comportamento mecânico, por meio do ensaio mecânico de flexão, de placas produzidas a partir osso cortical bovino, no reparo de fratura de tíbia de coelhos ex vivo. Para tal, 26 placas foram confeccionadas a partir de osso cortical bovino e conservadas em solução de sal a 150%. Foram utilizados três grupos para estudo: grupo GP (n=10), composto pelas placas ósseas; grupo GTP (n=16), tíbias de coelhos osteotomizadas e estabilizadas com placas ósseas e quatro parafusos; grupo GT (n=10), tíbias intactas. No ensaio biomecânico de flexão em três pontos, verificou-se a tensão máxima, deflexão máxima e rigidez. Os resultados foram submetidos ao teste de Kruskal-Wallis (p<0,05) e ao teste de Dunn. Comparando GT com o GTP, observou-se redução de 80% na tensão máxima. Também se notou redução de 87% na tensão máxima ao comparar GP com o GTP. Verificou-se que a placa de osso bovino possuiu maior tensão máxima que a tíbia do coelho. Houve redução a 52% na rigidez do GTP em relação ao GT. Não observou-se diferença significativa nesta propriedade entre GPT e GP. Observou-se diferença significativa entre os três grupos com relação à deflexão máxima, onde notou-se aumento de 100% e 30% nos grupos GTP e GP, respectivamente, em relação ao GT. Pode-se concluir que placas ósseas, no reparo de fratura de tíbia de coelhos ex vivo obtiveram propriedades mecânicas inferiores, quando comparada à tíbia intacta.
APA, Harvard, Vancouver, ISO, and other styles
6

Uzumaki, Emilia Tieko. "Desenvolvimento de filmes de carbono tipo diamante (DCL) obtidos pelo processo de imersão em plasma para implantes osteoarticulares." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/264998.

Full text
Abstract:
Orientador: Cecilia A. C. Zavaglia
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica
Made available in DSpace on 2018-08-07T02:27:14Z (GMT). No. of bitstreams: 1 Uzumaki_EmiliaTieko_D.pdf: 44142340 bytes, checksum: e8db433907d2fd2f88b260ed4cd8a791 (MD5) Previous issue date: 2006
Resumo: O carbono tipo diamante ("diamond-like carbon" - DLC) tem demonstrado características, como alta dureza, baixo atrito, resistência ao desgaste e à corrosão, e biocompatibilidade, que podem melhorar as propriedades de implantes sólidos e articulados. O processo de imersão em plasma vem sendo usado para depositar DLC em substratos tridimensionais, pois, com esta técnica, se consegue melhor adesão do que com as técnicas convencionais. Neste trabalho, filmes de DLC foram depositados, pelo processo de imersão em plasma, em lamínulas de vidro, silício e liga de titânio Ti-13Nb-13Zr. A caracterização da microestrutura, morfologia, dureza e adesão dos filmes de DLC foi feita por espectroscopia Raman, microscopia eletrônica de varredura (MEV), microscopia de força atômica (MFA), nanoindentação e ensaio de puxamento. Como exemplos de peças tridimensionais, filmes de DLC foram depositados em implantes osteoarticulares de quadril e joelho, titânio poroso (esponja de célula-aberta, semelhante à estrutura do osso esponjoso, expandida a vácuo), facas industriais, bisturi cirúrgico, engrenagem de motor, tubos de quartzo e de alumínio, e outros objetos. O filme obtido apresentou boas propriedades mecânicas, aumentando em 2 vezes a dureza da liga de Ti, alta adesão (filme sem interface definida e sem delaminação), resistência ao desgaste, baixa rugosidade e uniformidade de deposição em superfícies tridimensionais. Os resultados de corrosão (polarização de Tafel e espectroscopia de impedância eletroquímica em fluido corporal simulado) mostraram que o revestimento de DLC melhora a resistência da liga de Ti à corrosão. No ensaio de biocompatibilidade in vitro, com células fibroblásticas, foram estudados a citotoxicidade, adesão e morfologia celular (estudo citoquímico, microscopia de contraste de fase, MEV e MFA). No ensaio de biocompatibilidade in vivo, a liga de Ti-13Nb-13Zr, revestida com DLC, foi investigada em tecido muscular e ósseo de ratos após 4 e 12 semanas do procedimento cirúrgico. A interface formada entre o DLC e o tecido foi investigada por histologia convencional, e os implantes retirados por MEV. A interface entre o implante e o tecido ósseo, não descalcificado, foi estudada por MEV na modalidade retroespalhamento. Os resultados mostraram a biocompatibilidade in vitro e in vivo do filme de DLC, e foi verificado também que os implantes revestidos com DLC possuem resposta biológica mais favorável do que os implantes não revestidos
Abstract: Diamond-like carbon (DLC) films are often considered a suitable coating material for orthopaedic applications. It has proven characteristics, such as hardness, wear resistance, low friction coefficient and biocompatibility that improve the properties of solid and articulated implants. Recently, the plasma immersion process was used to deposit DLC films with superior adhesion properties to those prepared with conventional techniques. DLC coatings were deposited on glass coverslips, silicon (Si) and Ti-13Nb-13Zr substrates using the plasma immersion process. The microstructure, morphology, roughness, hardness and adhesion of DLC films were characterized using Raman spectroscopy, scanning electron microscopy (SEM), atomic force microscopy (AFM), nanoindentation and pull-test. As examples, DLC films produced by plasma immersion were deposited on industrial knives, surgical knives, knee implants, femoral heads (of hip prostheses), titanium foams, transmission gears of motorcycles, aluminium pipes, quartz pipes, and others objects. The corrosion susceptibility of DLC coatings produced by plasma immersion was studied in a simulated body fluid environment (Hanks' solution) using polarization test and electrochemical impedance spectroscopy (EIS). Electrochemical results showed that DLC coating produced by plasma immersion could improve corrosion resistance, and no significant damage has been observed. Vero cells (fibroblasts) were utilized for the in vitro biocompatibility studies, by cytotoxicity, adhesion and cell morphology (phase contrast microscopy, SEM, AFM, and cytochemical study). DLC-coated Ti-13Nb-13Zr was investigated in an animal model using the muscular tissue and femoral condyles of rats for intervals of 4 and 12 weeks postoperatively. The interface between the implants and tissue were analysed by light microscopy, and the removed implants by SEM. The SEM by backscattering was used to access the interface between the implants the bone tissue without decalcifying. Our results indicate that DLC coatings are biocompatible in vitro and in vivo
Doutorado
Materiais e Processos de Fabricação
Doutor em Engenharia Mecânica
APA, Harvard, Vancouver, ISO, and other styles
7

Hávová, Mariana. "Kostní implantáty na bázi železa." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-254467.

Full text
Abstract:
This thesis refers to Fe-based biodegradable materials and their potencial aplications in medicine, especially as temporary bone implants. This work generaly summaries aplications of biomaterial in medicine with more interest kept on biodegradable materials and their in-vivo corrosion. The experimental part refers to conduction of porous Fe-based materials with silica addition. The structure of prepared specimens is identified by EDX and XRD analysis. The imersion test and electrochemical studies were conducted to observe corrosion behaviour with respect to different concentration of silica. Potenciodynamic curves were obtained to determine corrosion potencial and corrosion current density of prepared samples.
APA, Harvard, Vancouver, ISO, and other styles
8

Pereira, Joana Maria Moreira. "Evaluation of in vitro biocompatibility of functionalized magnesium alloys for application in orthopedic implants." Master's thesis, 2021. http://hdl.handle.net/10773/30695.

Full text
Abstract:
Magnesium alloys have been widely studied and applied in the biomedical field, namely in the orthopedic area, due to their promising properties. Their biocompatibility, biodegradability, mechanical properties and osteogenic properties allow the use of these alloys as alternatives to the currently available materials. However, the uncontrolled corrosion and hydrogen formation in magnesium alloys can cause serious damages when introduced into the human body. In order to meet these challenges, different methods have been developed to control them, such as surface pre-treatments, coatings and alloying. The different systems produced, however, require a detailed assessment of biocompatibility for later use in the medical field. But there is still a gap in the assessment of biocompatibility, especially in the hemocompatibility of such materials. This work was conducted in the scope of the MAGICOAT project and aimed to assess the biocompatibility (cytotoxicity and hemocompatibility) of a multilayer system composed of a Mg1Ca alloy, pre-treated with hydroxyapatite, with a subsequent polyetherimide (PEI) coating containing calcium-loaded gelatin microcapsules or calcium carbonate particles. As both calcium-loaded gelatin microcapsules and calcium carbonate particles were to be included in the PEI coating, their morphology, release profile and their cytoto xicity were assessed prior to the biocompatibility assays of the complete system. The complete multilayer system was initially tested for cytotoxicity, analyzing the integrity of the cell membrane and cell proliferation, through LDH and WST-1 assays. After the results proved that the multilayer system was non-toxic, hemocompatibility tests were carried out. In vitro tests to verify the occurrence of hemolysis and activation of the complement system confirmed the hemocompatibility of the system after 4 hours of contact with the blood.
As ligas de magnésio têm sido amplamente estudadas e aplicadas no campo da biomedicina, nomeadamente na área ortopédica, devido às suas propriedades promissoras. A biocompatibilidade, biodegradabilidade, propriedades mecânicas e osteogénicas destas ligas, permitem o seu uso como alternativas aos materiais atualmente disponíveis. No entanto, a corrosão descontrolada e a formação de hidrogénio, nas ligas de magnésio, podem causar sérios danos quando introduzidas no corpo humano. Para enfrentar estes desafios, diferentes métodos foram desenvolvidos de forma a controlá-los, como pré-tratamentos de superfície, revestimentos e diferentes elementos de liga. Os diferentes sistemas produzidos, no entanto, requerem uma avaliação detalhada da sua biocompatibilidade para uso posterior na área médica. Porém, existe uma lacuna na avaliação da biocompatibilidade, principalmente na hemocompatibilidade destes materiais. Este trabalho foi realizado no âmbito do projeto MAGICOAT e teve como objetivo avaliar a biocompatibilidade (citotoxicidade e hemocompatibilidade) de um sistema multicamada composto por uma liga de Mg1Ca, pré-tratada com hidroxiapatite, e um revestimento, subsequente, de poliéterimida (PEI) contendo microcápsulas de gelatina com cálcio ou partículas de carbonato de cálcio. Como as microcápsulas de gelatina carregadas de cálcio e as partículas de carbonato de cálcio deveriam ser incluídas no revestimento PEI, a sua morfologia, perfil de libertação de cálcio e sua citotoxicidade foram avaliadas antes dos ensaios de biocompatibilidade do sistema completo. O sistema multicamada completo foi inicialmente testado relativamente à sua citotoxicidade, analisando-se a integridade da membrana celular e a proliferação celular, através dos ensaios de LDH e WST-1. Após os resultados comprovarem que o sistema multicamadas não era tóxico, foram realizados testes de hemocompatibilidade. Testes in vitro para verificar a ocorrência de hemólise e a ativação do sistema complemento confirmaram a hemocompatibilidade do sistema após 4 horas de contato com o sangue.
Mestrado em Materiais e Dispositivos Biomédicos
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Orthopedic implants – Biocompatibility"

1

T, Geesink Rudolph G., and Manley Michael T, eds. Hydroxylapatite coatings in orthopaedic surgery. New York: Raven Press, 1993.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

E, Lemons Jack, and ASTM Committee F-4 on Medical and Surgical Materials and Devices., eds. Quantitative characterization and performance of porous implants for hard tissue applications: A symposium. Philadelphia, PA: ASTM, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Kim, Kyo-Han. Surface modification of titanium for biomaterial applications. Hauppauge, N.Y: Nova Science Publishers, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

(Ramaswamy), Narayanan R., and Rautray Tapash R, eds. Surface modification of titanium for biomaterial applications. New York: Nova Science Publishers, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

1935-, Older John, Chas F. Thackray Ltd, and Implant Bone Interface Symposium (1989 : Midhurst, England), eds. Implant bone interface. London: Springer-Verlag, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

R, St John Kenneth, ASTM Committee F-4 on Medical and Surgical Materials and Devices., and Symposium on Biocompatibility of Particulate Implant Materials (1990 : San Antonio, Tex.), eds. Particulate debris from medical implants: Mechanisms of formation and biological consequences. Philadelphia, PA: ASTM, 1992.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Epinette, Jean-Alain M. D., and Rudolph G. T. Geesink. Hydroxyapatite Coated Hip and Knee Arthroplasty. Elsevier Science Ltd, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

A, Epinette J., and Geesink Rudolph G. T, eds. Hydroxyapatite coated hip and knee arthroplastry. Paris: Expansion Scientifique Française, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Orthopedic implants – Biocompatibility"

1

Andrianne, Y., F. Burny, J. Quintin, and M. Donkerwolke. "Aspects of the Failure of the Implanted Systems in Orthopedics and Traumatology." In Biocompatibility of Co-Cr-Ni Alloys, 249–65. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0757-0_24.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Kumar, Manjeet, Rajesh Kumar, Sandeep Kumar, and Chander Prakash. "Biomechanical Properties of Orthopedic and Dental Implants." In Research Anthology on Emerging Technologies and Ethical Implications in Human Enhancement, 506–18. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-8050-9.ch026.

Full text
Abstract:
The demand for the orthopedic and dental implants has increased sharply in last decade due to physical traumas and age-related deficiencies. The material used for orthopedic and dental implants should be biocompatible to ensure the adaptability of the implant in the human body. The mechanical stability of implants is dependent on mechanical properties and surface characteristics essential to ensure corrosion and wear resistance. The requirement of mechanical properties also differs substantially from load-bearing to non-load-bearing implants. There are many problems arising due to lack of sufficient biocompatibility, like infection, poor osseointegration, and excessive foreign body response. Fatigue failure, stress shielding, and bone resorption are some major problems associated with lack of mechanical stability. Numerous conventional materials, coatings, and nanomaterials have been used to enhance the implant stability.
APA, Harvard, Vancouver, ISO, and other styles
3

Kumar, Manjeet, Rajesh Kumar, Sandeep Kumar, and Chander Prakash. "Biomechanical Properties of Orthopedic and Dental Implants." In Handbook of Research on Green Engineering Techniques for Modern Manufacturing, 1–13. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-5445-5.ch001.

Full text
Abstract:
The demand for the orthopedic and dental implants has increased sharply in last decade due to physical traumas and age-related deficiencies. The material used for orthopedic and dental implants should be biocompatible to ensure the adaptability of the implant in the human body. The mechanical stability of implants is dependent on mechanical properties and surface characteristics essential to ensure corrosion and wear resistance. The requirement of mechanical properties also differs substantially from load-bearing to non-load-bearing implants. There are many problems arising due to lack of sufficient biocompatibility, like infection, poor osseointegration, and excessive foreign body response. Fatigue failure, stress shielding, and bone resorption are some major problems associated with lack of mechanical stability. Numerous conventional materials, coatings, and nanomaterials have been used to enhance the implant stability.
APA, Harvard, Vancouver, ISO, and other styles
4

Hallab, Nadim, Robert Urban, and Joshua Jacobs. "Corrosion and Biocompatibility of Orthopedic Implants." In Biomaterials in Orthopedics. Informa Healthcare, 2003. http://dx.doi.org/10.1201/9780203913086.ch3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

"Corrosion and Biocompatibility of Orthopedic Implants." In Biomaterials in Orthopedics, 69–98. CRC Press, 2003. http://dx.doi.org/10.1201/b14227-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

"Biotribology." In Tribomaterials, 363–90. ASM International, 2021. http://dx.doi.org/10.31399/asm.tb.tpsfwea.t59300363.

Full text
Abstract:
Abstract The chapter covers various aspects of biotribology in the context of dental care, orthopedic implants, haptics, eyewear, and stents and fixation devices. It also addresses the issue of biocompatibility and the effects of friction and contact pressure on skin.
APA, Harvard, Vancouver, ISO, and other styles
7

Okazaki, Yoshimitsu, and Kiyoyuki Chinzei. "Development of Orthopedic Implants with Highly Biocompatible Ti Alloys." In High Entropy Materials - Microstructures and Properties [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105389.

Full text
Abstract:
The material properties of metallic materials used for manufacturing of orthopedic implants are important for understanding the factors affecting the biological, biomechanical, and biochemical performances of orthopedic implants. This chapter will provide the test method for characterizing potential materials for metallic orthopedic device such as artificial joints and osteosynthesis. Particularly, the alloy design and low-cost manufacturing processes of titanium (Ti) metals, cytocompatibility of metals, biocompatibility and corrosion resistance of Ti alloys, and mechanical compatibility of orthopedic implants are summarized. Future trends on both materials and biological evaluation methods are also introduced here. Three-dimensional (3D) layer manufacturing technologies are expected as new technologies for manufacturing, artificial hip joint stems, acetabular cups, and femoral components and tibial trays of artificial knee joints among others. 3D layer manufacturing technologies are also expected for manufacturing porous materials such as acetabular components. It is possible to obtain marketing approval for highly biocompatible implants that are optimized for the skeletal structures and needs of patients by combining 3D layer manufacturing technologies with imaging technologies such as computed tomography (CT).
APA, Harvard, Vancouver, ISO, and other styles
8

Roy, Abhijit, Matthew Criado, John Ohodnicki, Howard Kuhn, and Prashant N. Kumta. "Material Aspects of Additively Manufactured Orthopedic Implants of Titanium Alloys." In Additive Manufacturing in Biomedical Applications, 201–22. ASM International, 2022. http://dx.doi.org/10.31399/asm.hb.v23a.a0006908.

Full text
Abstract:
Abstract Additive manufacturing, or three-dimensional printing technologies, for biomedical applications is rather different from other engineering components, particularly for biomedical implants that are intended to be used within the human body. This article contains two sections: "Design and Manufacturing Considerations of 3D-Printed, Commercially Pure Titanium and Titanium Alloy-Based Orthopedic Implants" and "Device Testing Considerations Following FDA Guidance" for additive-manufactured medical devices. These are further subdivided into five major focus areas: materials; design, printing, printing characteristics and parameters as well as postprinting validation; removal of the many manufacturing material residues and sterilization; physical, chemical, and mechanical assessments of the final devices; and biological considerations of all the final devices including biocompatibility.
APA, Harvard, Vancouver, ISO, and other styles
9

Marques de Castro, Moara, Débora Ribeiro Lopes, and Leonardo Viana Dias. "Mg-Based Composites for Biomedical Applications." In Magnesium Alloys [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95079.

Full text
Abstract:
Magnesium (Mg) is a promising material for producing temporary orthopedic implants, since it is a biodegradable and biocompatible metal which density is very similar to that of the bones. Another benefit is the small strength mismatch when compared to other biocompatible metals, what alleviates stress-shielding effects between bone and the implant. To take advantage of the best materials properties, it is possible to combine magnesium with bioactive ceramics and tailor composites for medical applications with improved biocompatibility, controllable degradation rates and the necessary mechanical properties. To properly insert bioactive reinforcement into the metallic matrix, the fabrication of these composites usually involves at least one high temperature step, as casting or sintering. Yet, recent papers report the development of Mg-based composites at room temperature using severe plastic deformation. This chapter goes through the available data over the development of Mg-composites reinforced with bioactive ceramics, presenting the latest findings on the topic. This overview aims to identify the major influence of the processing route on matrix refinement and reinforcement dispersion, which are critical parameters to determine mechanical and corrosion properties of biodegradable Mg-based composites.
APA, Harvard, Vancouver, ISO, and other styles
10

Kumaresan, Sakthiabirami, Soundharrajan Vaiyapuri, Jin-Ho Kang, Nileshkumar Dubey, Geetha Manivasagam, Kwi-Dug Yun, and Sang-Won Park. "Additive Manufactured Zirconia-Based Bio-Ceramics for Biomedical Applications." In Advanced Additive Manufacturing [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.101979.

Full text
Abstract:
Zirconia was established as one of the chief vital ceramic materials for its superior mechanical permanency and biocompatibility, which make it a popular material for dental and orthopedic applications. This has inspired biomedical engineers to exploit zirconia-based bioceramics for dental restorations and repair of load-bearing bone defects caused by cancer, arthritis, and trauma. Additive manufacturing (AM) is being promoted as a possible technique for mimicking the complex architecture of human tissues, and advancements reported in the recent past make it a suitable choice for clinical applications. AM is a bottom-up approach that can offer a high resolution to 3D printed zirconia-based bioceramics for implants, prostheses, and scaffold manufacturing. Substantial research has been initiated worldwide on a large scale for reformatting and optimizing zirconia bioceramics for biomedical applications to maximize the clinical potential of AM. This book chapter provides a comprehensive summary of zirconia-based bioceramics using AM techniques for biomedical applications and highlights the challenges related to AM of zirconia.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Orthopedic implants – Biocompatibility"

1

Badisha, Venkateswarlu, Suni Kumar Rajulapati, and Ratna Sunil Buradagunta. "Developing Mg Based Composites for Degradable Orthopedic Implant Applications: A Review." In 1st International Conference on Mechanical Engineering and Emerging Technologies. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-y3p82n.

Full text
Abstract:
Research on developing degradable implants from metals is one of the potential research fields in the biomedical engineering. Magnesium (Mg), iron (Fe) and zinc (Zn) are the three metallic systems widely investigated as potential materials to manufacture degradable orthopedic and stent applications. Among them, magnesium-based implants have shown promising properties suitable for orthopedic and stent applications. In spite of several benefits such as biocompatibility, non-toxicity and degradability, magnesium is associated with a few limitations including rapid corrosion and evolution of hydrogen during the degradation in the biological environment. Several materials engineering strategies have been employed to address the limitation of magnesium. Developing composites by incorporating suitable reinforcements into Mg is such promising route to develop Mg based implants with tailored properties. The present review provides a snap shot of the developments reported in development of Mg based composite for degradable implant applications. Different phases used to incorporate into Mg and the influenced properties with the future scope and the challenges are presented.
APA, Harvard, Vancouver, ISO, and other styles
2

Fashanu, Felicia F., Denis J. Marcellin-Little, and Barbara S. Linke. "Review of Surface Finishing of Additively Manufactured Metal Implants." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8419.

Full text
Abstract:
Abstract Metal additive manufacturing (AM) technologies, commonly referred to as 3D printing, provide a good prospect for medical applications because complex geometries and customized parts can be fabricated to meet individual patient needs. Orthopedic implants are a group of medical parts with high relevance for AM. This paper discusses relevant AM technologies, several orthopedic applications, materials and material properties, mechanical surface finishing techniques, and measurement techniques from the literature. Today, most metal 3D printed implants are manufactured through metal powder bed fusion technology which includes direct metal laser sintering (DMLS), selective laser melting (SLM), and electron beam melting (EBM). Common materials include titanium alloys, cobalt chromium (CoCr) and stainless steel, chosen because of their biocompatibility and mechanical properties. Surface finishing is most often required for 3D printed implants due to the relatively poor surface quality to meet the desired surface texture for the application. Typically, postprocessing is done mechanically, including manual and automated grinding, sandblasting, polishing, or chemically, including electrochemical polishing. This review also covers an overview of surface quality characterization of AM metal implants which includes surface texture and topography. The surface parameters used to characterize the surface of the implants: surface roughness (Ra), differences between the peak and valley (Rz), waviness, and micro-finish.
APA, Harvard, Vancouver, ISO, and other styles
3

Salahshoor, M., and Y. B. Guo. "Surface Modification of Biodegradable Magnesium-Calcium Implants by Burnishing." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-63730.

Full text
Abstract:
Magnesium-Calcium (MgCa) alloys have shown very promising potential to make biodegradable metallic orthopedic implants. Biodegradable metallic implants relieve the need for second surgery and avoid stress shielding common with permanent metallic implants. Moreover, they provide enough strength in load carrying orthopedic applications as opposed to polymeric counterparts. High degradation rate of these alloys is the pressing issue resulting in subcutaneous hydrogen bubbles and high pH values and ultimately imbalance in physiological reactions. Surface modification techniques has been implemented to enhance the biocompatibility of these alloys by matching their corrosion rate with bone healing rate and absorption rate of corrosion by-products. Low plasticity burnishing (LPB) is a novel technique that makes wide range of surface integrity characteristics and consequently corrosion rates attainable. This is instrumental in developing proper degradation rates with respect to local healing and absorptions rates present in each application. Besides, LPB can be applied on already available CNC machining centers and in that sense is very flexible. Hence, studying the effects of LPB process parameters on surface integrity is important. In this paper, effects of burnishing passes and their pattern on surface topography, surface roughness, surface/subsurface microhardness, microstructure, and surface residual stresses of MgCa0.8 (wt%) implants are investigated.
APA, Harvard, Vancouver, ISO, and other styles
4

Gong, Haibo, Antonios Kontsos, Yoontae Kim, Peter I. Lelkes, Qingwei Zhang, Donggang Yao, Kavan Hazeli, and Jack G. Zhou. "Micro Characterization of Mg and Mg Alloy for Biodegradable Orthopedic Implants Application." In ASME 2012 International Manufacturing Science and Engineering Conference collocated with the 40th North American Manufacturing Research Conference and in participation with the International Conference on Tribology Materials and Processing. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/msec2012-7395.

Full text
Abstract:
Magnesium as a candidate metallic biomaterial for biodegradable orthopedic implants was evaluated in-vitro in terms of degradation behavior, biocompatibility and mechanical property both in macro- and micro-scale. Micro structure of pure Mg and AZ61 after degradation in both simulated body fluid (SBF) and cell culture environment were analyzed. Different from AZ61, pure Mg degraded at a higher rate and attracted large amount of salt precipitation which formed a layer covering the surface. Much less pitting degradation and salt deposition were observed on both pure Mg and AZ61 in cell culture environment compared to in SBF. After culturing for 7 days, EAhy926 cells growing on AZ61 showed significant higher proliferation rate as of cells growing on pure Mg. Higher proliferation rates indicated that cells grew better on slow-degrading AZ61 than on fast-degrading pure Mg. Cells growing on AZ61 proliferated much better and assembled together to form a consistent tissue-like micro-structure, while cells spread and reached out on the surface of pure Mg, possibly due to low cell density and lack of cellular communication. The elastic modulus and tensile yield strength of magnesium are closer to those of natural bone than other commonly used metallic biomaterials. It was shown that Mg was biodegradable, biocompatible and had appropriate mechanical strength, thus Mg and its alloys showed great potential for deployment in a new generation of biodegradable orthopedic implants.
APA, Harvard, Vancouver, ISO, and other styles
5

McGhee, Paul, Devdas Pai, Sergey Yarmolenko, Jagannathan Sankar, Zhigang Xu, Sudheer Neralla, and Yongjun Chen. "Directional-Tribological Investigation of Magnesium Alloys Under As-Cast and Hot Extrusion Conditions." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51920.

Full text
Abstract:
In recent years, magnesium (Mg) and its alloy are being studied for their potential use in orthopedic implants with the novel ability to biodegrade after the implant serves its therapeutic function. Pure Mg, by itself, would not be suitable for use in a load-bearing implant application, due to its high corrosion rate and poor tribological properties. However, through proper alloying, this degradable metal is capable of achieving good mechanical properties reasonably similar to bone, a retarded rate of corrosion and enhanced biocompatibility. Previous studies have shown that alloying Mg with aluminum, lithium, rare earth (RE), zinc (Zn), and calcium (Ca) result in lower corrosion rates and enhanced mechanical properties. Despite the growing popularity of Mg and it alloys, there is relatively little information in the literature on their wear performance. In this paper, we report on an investigation of the directional tribological properties of Mg and Mg-Zn-Ca-RE alloy fabricated via two different manufacturing processing routes: as-cast and hot-extruded after casting, with extrusion ratios of 10 and 50. Pure Mg was cast 350°C. After casting, Mg-Zn-Ca-RE alloy was heat-treated at 510°C. Another Mg-Zn-Ca-RE alloy was hot-extruded at 400°C. Dry sliding wear tests were performed on as-cast and hot-extruded pure Mg and Mg-Zn-Ca-RE alloys using a reciprocating test configuration. Wear rate, coefficient of friction and wear coefficient were measured under applied loads ranging from 0.5–2.5N at sliding frequency of 0.2 Hz for 120 cycles, using microtribometery. Wear properties of the extruded specimen were measured in cross-section and longitudinal section. In the longitudinal section studies, wear properties were investigated along the extrusion direction and the transverse direction. Hardness properties were evaluated using microindentation. Cross-section and longitudinal section were indented with a Vickers indenter under applied load of 2.94 N. Alloying and extrusion enhanced the mechanical properties significantly, increased hardness by 80% and wear resistance by 50% compared to pure Mg. Despite the low hardness in both Mg and the Mg alloy cross-sections, the cross-sections for both displayed higher wear resistance compared to the longitudinal section. In the longitudinal section, wear resistance was higher along the transverse direction of the longitudinal section for both Mg and the Mg alloy. The wear coefficient was used to evaluate how the wear behavior of the material varied with respect to alloying, fabrication process, and direction of wear. The wear coefficient of pure Mg decreased as the extrusion ratio increased, thus, increasing the specific wear rate. The opposite behavior was found in the Mg alloy: as the wear coefficient increases, the specific wear rate decreases. The active wear mechanisms observed on the worn surface of Mg were fatigue, abrasive, adhesive and delamination wear. The same wear mechanisms were observed in the Mg alloy except for fatigue wear. Surface microstructure and topographical characterization were conducted using optical microscopy, scanning electron microscopy mechanical stylus profilometry, and optical profilometry.
APA, Harvard, Vancouver, ISO, and other styles
6

Hu, Yingbin, Shahrima Maharubin, Weilong Cong, and George Tan. "Laser Engineered Net Shaping of Titanium-Silver Alloy for Orthopedic Implant." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6611.

Full text
Abstract:
Post-surgery infection is one of the major causes of orthopedic implantation failure. Silver has been widely used as a broad-spectrum antimicrobial component in medical instrument. This paper presents a pioneering study on laser engineered net shaping (LENS) of titanium-silver (Ti-Ag) alloy for implant-related infection control. Ti-Ag alloy coupons were 3D printed through LENS process and characterized by 3D microscopy. The biofilm resistance and biocompatibility of the alloy samples were investigated. Results showed that the alloy significantly reduced the bacterial attachment for both Gram-positive and Gram-negative strains, and has no cytotoxicity to human fibroblast cells. This study demonstrated a great potential of laser 3D printed Ti-Ag alloy for orthopedic implant.
APA, Harvard, Vancouver, ISO, and other styles
7

Kotoka, Rubenv, Ashlyn Worthy, Erica Clinard, Devdas Pai, Jag Sankar, and Sergey Yarmolenko. "Application of Magnesium Oxide Functional Coating for Controlling the Corrosion of Magnesium for Implant Applications." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-87579.

Full text
Abstract:
Magnesium and its alloys are great candidates for uses in orthopedic implant applications due to their biocompatibility, mechanical properties and degradability. However, they are susceptible to accelerated degradation rates due to micro galvanic corrosion, which leads to unpredictable corrosion behavior. The poor corrosion resistance limitation restricts the practical use of Mg for implant application, where exposure to aggressive environment of body fluids is unavoidable. This paper describes the growth, characterization and corrosion analyses of MgO coatings which can slow down the degradation of Mg. Bilayer Mg-MgO system was prepared by pulse DC magnetron sputtering method and used as a model for evaluation of sustainability of MgO on Mg surface. Immersion tests were performed on Mg-MgO system with varying thicknesses using the optical density method. The tests were performed at room temperature and 37°C with deionized water, phosphate buffered saline, albumin, media, media with fetal bovine serum and saline solutions. The result showed that degradation rate of MgO on Mg substrate significantly depends on media.
APA, Harvard, Vancouver, ISO, and other styles
8

Rasool, Tabinda, Syed Rehan Ahmed, Iqra Ather, Madeeha Sadia, Rashid Khan, and Ali Raza Jafri. "Synthesis and Characterization of Hydroxyapatite Using Egg-Shell." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51933.

Full text
Abstract:
Advancement in materials science and manufacturing processes helps in expanding the application span of materials in biotechnology. The technological development of biocompatible materials aids in improving health conditions, cancerous treatment, organ implants, and as well as provides several techniques to patient treatment. Hydroxyapatite (HAP) is considered as a potential material for orthopedics and dental implants due to its eminent biocompatibility and natural apatite characteristics. It is regarded as viable and cost effective solution of many biomedical applications. Major challenges in expanding the application span of HAP include obtaining optimum mechanical, chemical, and biological properties simultaneously while making its manufacturing processes cost effective. The main purpose of the current work is to synthesize and characterize high strength HAP with high degree of crystallinity and purity, which could be able to fulfill the requirements of modern biological materials. In this work, egg-shell which is considered as garbage is utilized as calcium source to synthesize HAP. Initially, egg-shells are properly cleaned with distilled water and dried. Ball milling operation is used to produce egg-shell particles of nano to micron range. The particles then mixed with controlled amount of phosphoric acid. The mixture is then sintered by heat treating at 900°C for 2 hours. The heat treatment (sintering) process is used to enhance the density as well as strength of egg-shell material. After synthesis of HAP, it is characterized through X-ray diffraction, scanning electron microscopy, and laser particle analyzer. Composition of HAP is investigated through XRD. Furthermore, surface topography of nano-crystalline HAP powder is measured through Scanning Electron Microscope while particle size distribution is found through laser particle analyzer. It is found that the addition of phosphoric acid in milled egg-shell and heat treatment give rise HAP in the sample. In addition, particle size varies from hundreds of nanometers to several micrometers. The results and analysis of the current work may provide insight of different properties which may lead to the development of optimum and cost effective HAP material. The current study could be further extended in increasing application envelop of biocompatible materials.
APA, Harvard, Vancouver, ISO, and other styles
9

Zhang, Qingwei, Vadym Mochalin, Ioannis Neitzel, Yury Gogotsi, Peter I. Lelkes, and Jack Zhou. "The Study on PLLA-Nanodiamond Composites for Surgical Fixation Devices." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-38287.

Full text
Abstract:
Biopolymers have a great potential in biomedical engineering, having been used as scaffolds for hard and soft tissues, such as bone and blood vessels for many years. More recently biopolymers have also found applications in surgical fixation devices. Compared with conventional metal fixation devices, bone grafts and organ substitutes, biopolymer products have advantages of no long-term implant palpability or temperature sensitivity, predictable degradation to provide progressive bone loading and no stress shielding, all of which leads to a better bone healing, reduced patient trauma and cost, elimination of second surgery for implant removal, and fewer complications from infections. However lack of initial fixation strength and bioactivity are two major concerns which limited more widespread applications of biopolymers in orthopedic surgery. Nanodiamond is attractive for its use in reinforcement of composite materials due to their outstanding mechanical, chemical and biological properties. Nanotechnology shows us many innovations and it is generally accepted view that many could be further developed and applied in tissue engineering. In this work, we conduct poly(L-lactic acid) (PLLA) and octadecylamine functionalized nanodiamond (ND-ODA) composite research to optimize the polymer/ND interface, thus to reinforce the mechanical strength. Composites comprising PLLA matrix with embedded ND-ODA were prepared by mixing PLLA/chloroform solution with chloroform suspension of nanodiamonds at concentrations of 0–10 by weight percent. The dispersion of ND-ODA was observed by transmission electron microscopy (TEM). TEM micrographs show that ND-ODA can disperse uniformly in PLLA till 10% wt. Nanoindentation result shows the mechanical strength of ND-ODA/PLLA composites improving following increasing the concentration of ND-ODA in composites. The noncytotoxicity of ND-ODA was demonstrated on 7F2 Osteoblasts. To test the usefulness of ND-ODA/PLLA composites as scaffolds for supporting cell growth, 7F2 Osteoblasts were cultured on scaffolds for 6 days. The attachment and proliferation of 7F2 on all scaffolds were assessed by fluorescent nuclear staining with Hoechst 33258 and Alamar BlueTM assay. The results showed that the adding ND-ODA does small influence cell growth, which indicates the composites have good biocompatibility. The morphology of 7F2 cells growing on all ND-ODA/PLLA composite scaffolds was determined by SEM, which confirms the Osteoblasts spread on the scaffolds. All these results combined suggest that ND-ODA/PLLA might provide a novel composite suitable for surgical fixation devices.
APA, Harvard, Vancouver, ISO, and other styles
10

Ibrahim, Hamdy, Andrew D. Klarner, Behrang Poorganji, David Dean, Alan A. Luo, and Mohammad Elahinia. "The Effect of Heat-Treatment on Mechanical, Microstructural, and Corrosion Characteristics of a Magnesium Alloy With Potential Application in Resorbable Bone Fixation Hardware." In ASME 2016 11th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/msec2016-8822.

Full text
Abstract:
Mg alloys are promising materials for bone implant applications mainly due to their low specific density, desirable stiffness and bioresorbability in the human body. Mg-Zn-Ca alloys are among the most promising materials for resorbable orthopedic fixation devices due to their superior biocompatibility. However, the mechanical and corrosion properties of the as-cast Mg-Zn-Ca alloys are insufficient. Heat treatment is a practical approach for strengthening Mg alloys especially after the fabrication of porous structures and 3D-printed components. We have investigated heat treatment of these devices and have studied the resulting microstructure of Mg-1.6Zn-0.5Ca (wt. %) alloys by hardness, compression, scanning electron microscopy (SEM), and electrochemical and immersion corrosion tests. Mg-1.6Zn-0.5Ca alloy was prepared with high purity Mg, Zn and Ca by casting. The cast ingots were solution-treated at 510 °C for 3 h then quenched in water. The quenched ingots were age hardened in an oil bath at 200 °C for 2 h. Pure Mg, as-cast and heat-treated Mg-1.6Zn-0.5Ca alloy ingots were cut into coupons to characterize their mechanical and corrosion properties. In vitro corrosion tests were conducted in modified simulated body fluid (m-SBF) at pH 7.4 and 37 °C. The hardness of the Mg-Zn-Ca alloy was significantly increased from 52.6 to be 66.8 HV after heat treatment. Also, the compression test results revealed that the heat-treated alloy has the highest compressive yield and ultimate strengths without significant change in stiffness and maximum strain. The mass loss of the Mg-Zn-Ca alloy by week 4 of the in vitro immersion test reduced from 174.6 mg/cm2 for the as-cast alloy to 101.7 mg/cm2 after the heat-treatment process. Heat-treatment was found to be a powerful post-shaping process not only to enhance the mechanical properties of the Mg-1.6Zn-0.5Ca (wt. %) alloy, but also to significantly improve its biocorrosion properties. Such heat-treated alloys can also be coated with biocompatible ceramics that provide additional protection from corrosion during the bone healing period (3–4 months).
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Orthopedic implants – Biocompatibility' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography