Journal articles on the topic 'Orla Kiely'

Purpose This paper aims to consider the visual literacy mobilized by consumers in their use of brand aesthetics to construct and communicate a curated self. Design/methodology/approach The research surveyed a range of visual material from Instagram. Specifically, the goal was to use “compositional interpretation”, an approach to visual analysis that is not methodologically explicit but which, in itself, draws upon the visual literacy of the researcher to provide a descriptive analysis of the formal visual quality of images as distinct from their symbolic resonances. The research also incorporates 10 phenomenological-type interviews with consumers. Consistent with a phenomenological approach, informants were selected because they have “lived” the experience under investigation, in this case requiring them to be keen consumers of the Orla Kiely brand. Findings Findings indicate that consumers deploy their visual literacy in strategic visualization (imaginatively planning and coordinating artifacts with other objects in their collection, positioning and using them as part of an overall visual repertoire), composition (becoming active producers of images) and emergent design (turning design objects into display pieces, repurposing design objects or simply borrowing brand aesthetics to create designed objects of their own). Research limitations/implications This research has implications for the understanding of visual literacy within consumer culture. Engaging comprehensively with the visual compositions of consumers, this research moves beyond brand symbolism, semiotics or concepts of social status to examine the self-conscious creation of a curated self. The achievement of such a curated self depends on visual literacy and the deployment of abstract design language by consumers in the pursuit of both aesthetic satisfaction and social communication. Practical implications This research has implications for brand designers and managers in terms of how they might control or manage the use of brand aesthetics by consumers. Originality/value To date, there has been very little consumer research that explores the nature of visual literacy and even less that offers an empirical investigation of this concept within the context of brand aesthetics. The research moves beyond brand symbolism, semiotics and social status to consider the deployment of abstract visual language in communicating the curated self.

Abstract. The contribution uses the example of the 1969 Congress of German Geographers in Kiel to illustrate how traditions are born and passed on in German-speaking geography. By means of hermeneutic source criticism, it investigates how the events of „Kiel 1969“ gave rise to a myth. It concludes that the congress's participants experienced „Kiel 1969“ as the site of an enormously dense social interaction within their science. Most importantly, participants' suggestive oral reports in the aftermath of the congress turned it into the „myth of Kiel“, which became an essential driving force of German-speaking geography's modernization.

The paper looks at two book-length poems by Alice Oswald’s: Dart (2002) and Memorial (2011) as translation projects, with an aim to understand both the nature of Oswald’s poetic practice and her concept of what is the meaning and goal of translation in creative work. I claim that translation, in the special sense the poet gives to this term, is at the very core of her work. In my analysis I concentrate on the physical aspect of Oswald’s poetic practice, the role of the body, movement in space, muscular effort, rhythm and memorization of poetry in her projects. I also look at the ways of crossing the divide between the human and non-human, linking language to the voice of the natural world and returning to oral poetry in her work.

Autor z perspektywy badacza historii współczesnej wskazuje nie tylko potencjalne wspólne podstawy, lecz także różnice w wykorzystywaniu metody oral history w perspektywie interdyscyplinarnej. Na podstawie praktycznego doświadczenia dochodzi do wniosku, że założenia oral history i innych dyscyplin, dla których materiał badawczy stanowią rozmowy, są bardzo podobne. Różnica między poszczególnymi dziedzinami leży w konkretnych metodach. Artykuł jest refleksją nad pewnymi aktualnymi problemami oral history. Punktem wyjścia autora jest obecna sytuacja, kiedy to z jednej strony wzrasta zainteresowanie oral history, bo przecież ludzie potrzebują opowieści, a z drugiej strony z każdym dniem coraz bardziej tracą zdolność opowiadania historii życia czy ich chętnego słuchania. Przy tej okazji wprowadza kwestię „zabiegania” w dzisiejszych czasach, dążenia do uproszczenia i skrótu w kontekście relacji narracyjnej. Dalej zajmuje się pewnymi kwestiami metodologicznymi, którym w przeszłości nie poświęcano szczególnej uwagi. Chodzi tu szczególnie o problem subiektywności, pamięci i jej roli w konstruowaniu narracji biograficznych czy kwestię kontekstu społecznego i politycznego (zarówno przeszłego, jak i współczesnego), w którym realizowane są wywiady. W zakończeniu wskazuje, w jaki sposób badaniom oral history pomaga poznanie i zrozumienie nie tylko przeszłości, lecz także współczesności. W tym właśnie bowiem tkwi wielka siła tej metody, która jest inspiracją dla badaczy innych dziedzin nauk społecznych, dla których podstawowym źródłem jest rozmowa.

Background:Rheumatoid arthritis (RA) is a multisystem inflammatory disorder that affects the joints and other body tissues. Approximately 1% of the worldwide population is living with RA 1. Methotrexate is the first line DMARD used for treatment of RA 2.Objectives:The aim of this study was to analyse MTX use in achieving remission in early arthritis patients and to compare the route of administration to see whether it affects the time interval to remission.Methods:An observational, prospective study was performed on patients’ data available from our Early Arthritis Cohort. Newly diagnosed patients with RA meeting the American College of Rheumatology (ACR) criteria were enrolled in T2T programme led by Advanced Nurse Practitioner (ANP) with consultant supervision. To assess their response to treatment, we used the Clinical Disease Activity Index (CDAI). SPSS was used to analyse the data.Results:A total of 353 have completed the programme and of these, 341were commenced on MTX. 208 patients (61%) were female. The MTX starting dose was 15mg for 88.4% (305/341) of patients. The median time to first increment in MTX dose was 7 weeks and the figure 1 was identical for the second increment. Of the 238 patients who started oral MTX, 18.48% (44) discontinued. 21.4% (22) of the 103 who started on SC-MTX discontinued (The p-value for discontinuation was 0.538). P-value for likelihood of achieving remission based on oral versus SC MTX was 0.248 and the p-value for time to achieve remission was 0.671 for oral versus SC MTX groups, see figure 1 attached.Conclusion:Patients in this cohort are being started promptly on an appropriate dose of MTX and are escalated in a timely manner in-line with guidelines. Analysis showed no statistically significant difference in terms of time to remission, likelihood of achieving remission or discontinuation of MTX between oral and SC-MTX groups.References:[1]Carmona L, Villaverde V, Hernández-García C, Ballina J, Gabriel R, Laffon A, et al. The prevalence of rheumatoid arthritis in the general population of Spain. Rheumatology. 2002;41(1):88-95.[2]Rachapalli SM, Williams R, Walsh DA, Young A, Kiely PDW, Choy EH, et al. First-line DMARD choice in early rheumatoid arthritis—do prognostic factors play a role? Rheumatology. 2010;49(7):1267-71.Disclosure of Interests:None declared

ObjectivePostprandial (pp) lipid metabolism is associated with insulin resistance and type 2 diabetes. In young men, pp triglycerides (TGs) are more strongly associated with traits of metabolic syndrome (MS) than fasting TGs. We established a cohort of middle-aged men selected for traits of MS and pp lipid metabolism to determine if fasting TGs or pp TGs are more closely related to MS.Research design and methodsA total of 1558 men were characterized for MS. A total of 755 men underwent an oral metabolic tolerance test consisting of a standardized high-fat meal and an oral glucose tolerance test. Blood samples were drawn in the fasting state and hourly until 9 h to determine pp TGs and free fatty acids. Glucose and insulin were analyzed until 5 h pp.ResultsIn the overall cohort, 329 subjects (21.1%) had a complete MS based on the Adult Treatment Panel III criteria, and 650 subjects (41.7%) had a complete MS based on the International Diabetes Federation criteria. The association of pp TGs with MS parameters was not stronger than the association of fasting TGs with them. Pp TGs were independently associated with β-cell function.ConclusionsPp TGs did not show a higher correlation with MS traits than fasting TGs. This finding is probably due to the high incidence of overweight subjects in this middle-aged cohort.

IntroductionOral health and oral health-related quality of life (OHrQL) of residents in German long-term residential care (LRC) are poor. We will develop an evidence-based catalogue of interventions (‘Oral Health Toolbox’) and provide care-accompanying reinstruction and remotivation of nursing staff by dental assistants (DA). We hypothesise that such intervention will significantly improve OHrQL, daily oral hygiene/care behaviour and is cost-effective.Methods and analysisA scoping review will be used to identify possible intervention components. Mixed methods will be used to identify barriers and enablers of oral hygiene and care in German LRC. The result will be the ‘Oral Health Toolbox’, a two-phased instrument supporting both initial intervention allocation to improve oral health/hygiene and reinstruction/remotivation. A two-arm clustered, randomised controlled trial (ratio of 1:1 via block randomisation) will be performed in LRC in Rhineland-Palatinate, Germany. Each nursing home represents a cluster. Based on a feasibility study, considering clustering and possible attrition, we aim at recruiting 618 residents in 18 clusters. In the intervention group, dentists will assign one or more intervention component from the box (phase 1). During follow-up, nursing staff will be reinstructed and remotivated by DA, who use the box to decide how to maintain the intervention (phase 2). In the control group residents will receive care as usual. The primary outcome, OHrQL, will be measured using the General Oral Health Assessment Index. Secondary outcomes include pain condition, general health-related quality of life, caries increment, oral/prosthetic hygiene and gingival status, incidence of dental emergencies and hospitalisations, and cost-utility/effectiveness. The endpoints will be measured at baseline and after 12 months. For our primary outcome, a mixed-linear model will be used within an intention-to-treat analysis. A process evaluation using mixed methods will be conducted alongside the trial.Ethics and disseminationEthical approval by the University of Kiel was granted (D480/18).Trial registration numberNCT04140929.

Abstract This article reports Chilean and Finnish foreign-language (FL) teachers’ perceptions of teaching and study realities in their own FL classrooms. Communicative language teaching (CLT) is used as the teaching–studying–learning methodological framework of an international KIELO project (= the acronym for Finnish “kieltenopetus” meaning “language teaching”), whose online survey was used to collect data for this article. We aim at answering the following research question: What are the FL teachers’ main approaches to teaching and studying in Chilean and Finnish FL classrooms and what is the FL classroom teaching and study reality like in these two countries? The data were collected from 83 Chilean and 147 Finnish FL teachers through an online survey covering 15 key themes of CLT and including 115 Likert-scale statements and 8 open-ended questions. In the descriptive data analysis, both Chilean and Finnish FL teachers claim that they encourage their students to use the target language considerably and that they use communicative oral tasks. For both groups of participants, however, teacher-centeredness and use of textbook score relatively high. The two-cluster analysis revealed a context-dependent cluster and a context-independent cluster. Context-dependent teachers tended to favor communicative oral tasks, real-life tasks and their own language tasks, whereas context-independent teachers favored more non-communicative tasks. Context-dependent teachers proved more student-centered than context-independent teachers. For Chilean and Finnish research participants, the use of mother tongue in foreign language classrooms appears to be an issue despite the growing need of foreign language communication.

This special issue of the ZAS Papers in Linguistics contains a collection of papers of the French-German Thematic Summerschool on "Cognitive and physical models of speech production, and speech perception and of their interaction". Organized by Susanne Fuchs (ZAS Berlin), Jonathan Harrington (IPdS Kiel), Pascal Perrier (ICP Grenoble) and Bernd Pompino-Marschall (HUB and ZAS Berlin) and funded by the German-French University in Saarbrücken this summerschool was held from September 19th till 24th 2004 at the coast of the Baltic Sea at the Heimvolkshochschule Lubmin (Germany) with 45 participants from Germany, France, Great Britain, Italy and Canada. The scientific program of this summerschool that is reprinted at the end of this volume included 11 key-note presentations by invited speakers, 21 oral presentations and a poster session (8 presentations). The names and addresses of all participants are also given in the back matter of this volume. All participants was offered the opportunity to publish an extended version of their presentation in the ZAS Papers in Linguistics. All submitted papers underwent a review and an editing procedure by external experts and the organizers of the summerschool. As it is the case in a summerschool, papers present either works in progress, or works at a more advanced stage, or tutorials. They are ordered alphabetically by their first author's name, fortunately resulting in the fact that this special issue starts out with the paper that won the award as best pre-doctoral presentation, i.e. Sophie Dupont, Jérôme Aubin and Lucie Ménard with "A study of the McGurk effect in 4 and 5-year-old French Canadian children".

Myths and Word of MouthJens Peter Ægidius: Braga Talks, Norse Myths and Narrative Myths in the Danish Tradition (to 1910). Odense 1985.Reviewed by Vilhelm NielsenThe title Braga Talks is taken from Grundtvig, who in 1843-44 gave 25 lectures under this heading; these are treated in detail by Ægidius. The phrase has since been misunderstood, however, and misused to mean words without content or basis in reality. Braga, the god of poetry, has been forgotten and the emphasis has been transferred to the word talk. The title of this book expresses a slipping from the mythology itself into its narrative reproduction. While working on the preface and the introduction to Norse Mythology (1832) Grundtvig made the discovery (as Thaning has proved) that myths are oral. This was one of the slow discoveries he made, and could have been made the main theme of this book, which says little that is new about Grundtvig’s use of his sources. It does, however, offer a great deal on the narrative tradition in use at the grundtvigian folk high schools, which has been revived in this century by Aage Møller, a clergyman and high school teacher. Unfortunately this phase has not been treated, as the book stops at 1910. Ægidius has, however, included Ludvig Christian Møller, the narrative historian, who was Grundtvig’s disciple and who even before him gave historical talks for both men and women at Borch’s hostel in the 1830s. His narration of myths and legends was only his introduction to narratives from medieval history. The other major characters in Ægidius’ book are Christian Flor and Ludvig Schrøder. Flor was originally Professor of Danish at Kiel but became principal of the first Danish folk high school at Rødding in 1844. Schr.der became principal of Askov folk high school, which from 1864 onwards carried the stamp of his personality. Ægidius claims, and the reviewer underlines this new information, that Schrøder did not give up teaching the myths, even though from 1884 onwards he went on to talk about Denmark’s natural resources. Unfortunately we have only comprehensive notes to the lectures but no myth narratives in written form from his side. His lectures on myth were apparently not the same from year to year, but they were wellprepared and reformulated every time, a necessary precondition for their being both “animated” and mythically “sound”, not in fact lectures but “proper stories”, as Grundtvig says in 1838. The reviewer looks forward to a continuation of the book to include an assessment of Aage Møller’s attempt to revive the tradition — and possibly as a guideline for the most recent trends.

-Charles V. Carnegie, W. Jeffrey Bolster, Black Jacks: African American Seamen in the age of sail. Cambridge MA: Harvard University Press, 1997. xiv + 310 pp.-Stanley L. Engerman, Wim Klooster, Illicit Riches: Dutch trade in the Caribbean, 1648-1795. Leiden: KITLV Press, 1998. xiv + 283 pp.-Luis Martínez-Fernández, Emma Aurora Dávila Cox, Este inmenso comercio: Las relaciones mercantiles entre Puerto Rico y Gran Bretaña 1844-1898. San Juan: Editorial de la Universidad de Puerto Rico, 1996. xxi + 364 pp.-Félix V. Matos Rodríguez, Arturo Morales Carrión, Puerto Rico y la lucha por la hegomonía en el Caribe: Colonialismo y contrabando, siglos XVI-XVIII. San Juan: Editorial de la Universidad de Puerto Rico y Centro de Investigaciones Históricas, 1995. ix + 244 pp.-Herbert S. Klein, Patrick Manning, Slave trades, 1500-1800: Globalization of forced labour. Hampshire, U.K.: Variorum, 1996. xxxiv + 361 pp.-Jay R. Mandle, Kari Levitt ,The critical tradition of Caribbean political economy: The legacy of George Beckford. Kingston: Ian Randle, 1996. xxvi + 288., Michael Witter (eds)-Kevin Birth, Belal Ahmed ,The political economy of food and agriculture in the Caribbean. Kingston: Ian Randle; London: James Currey, 1996. xxi + 276 pp., Sultana Afroz (eds)-Sarah J. Mahler, Alejandro Portes ,The urban Caribbean: Transition to the new global economy. Baltimore: John Hopkins University Press, 1997. xvii + 260 pp., Carlos Dore-Cabral, Patricia Landolt (eds)-O. Nigel Bolland, Ray Kiely, The politics of labour and development in Trinidad. Barbados, Jamaica, Trinidad and Tobago: The Press University of the West Indies, 1996. iii + 218 pp.-Lynn M. Morgan, Aviva Chomsky, West Indian workers and the United Fruit Company in Costa Rica, 1870-1940. Baton Rouge: Louisiana State University Press, 1996. xiii + 302 pp.-Eileen J. Findlay, Maria del Carmen Baerga, Genero y trabajo: La industria de la aguja en Puerto Rico y el Caribe hispánico. San Juan: Editorial de la Universidad de Puerto Rico, 1993. xxvi + 321 pp.-Andrés Serbin, Jorge Rodríguez Beruff ,Security problems and policies in the post-cold war Caribbean. London: :Macmillan; New York: St. Martin's, 1996. 249 pp., Humberto García Muñiz (eds)-Alex Dupuy, Irwin P. Stotzky, Silencing the guns in Haiti: The promise of deliberative democracy. Chicago: University of Chicago Press, 1997. xvi + 294 pp.-Carrol F. Coates, Myriam J.A. Chancy, Framing silence: Revolutionary novels by Haitian women. New Brunswick NJ: Rutgers University Press, 1997. ix + 200 pp.-Havidán Rodríguez, Walter Díaz, Francisco L. Rivera-Batiz ,Island paradox: Puerto Rico in the 1990's. New York: Russel Sage Foundation, 1996. xi + 198 pp., Carlos E. Santiago (eds)-Ramona Hernández, Alan Cambeira, Quisqueya la Bella: The Dominican Republic in historical and cultural perspective. Armonk NY: M.E. Sharpe, 1996. xi + 272 pp.-Ramona Hernández, Emilio Betances ,The Dominican Republic today: Realities and perspectives. New York: Bildner Center for Western Hemisphere studies, CUNY, 1996. 205 pp., Hobart A. Spalding, Jr. (eds)-Bonham C. Richardson, Eberhard Bolay, The Dominican Republic: A country between rain forest and desert. Wekersheim, FRG: Margraf Verlag, 1997. 456 pp.-Virginia R. Dominguez, Patricia R. Pessar, A visa for a dream: Dominicans in the United States. Boston: Allyn and Bacon, 1995. xvi + 98 pp.-Diane Austin-Broos, Nicole Rodriguez Toulis, Believing identity: Pentecostalism and the mediation of Jamaican ethnicity and gender in England. Oxford NY: Berg, 1997. xv + 304 p.-Mary Chamberlain, Trevor A. Carmichael, Barbados: Thirty years of independence. Kingston: Ian Randle Publishers, 1996. xxxv + 294 pp.-Paul van Gelder, Gert Oostindie, Het paradijs overzee: De 'Nederlandse' Caraïben en Nederland. Amsterdam: Bert Bakker, 1997. 385 pp.-Roger D. Abrahams, Richard D.E. Burton, Afro-Creole: Power, Opposition, and Play in the Caribbean. Ithaca NY: Cornell University Press, 1997. x + 297 pp.-Roger D. Abrahams, Joseph Roach, Cities of the dead: Circum-Atlantic performance. New York NY: Columbia University Press, 1996. xiii + 328 pp.-George Mentore, Peter A. Roberts, From oral to literate culture: Colonial experience in the English West Indies. Kingston, Jamaica: The Press University of the West Indies, 1997. xii + 301 pp.-Emily A. Vogt, Howard Johnson ,The white minority in the Caribbean. Princeton NJ: Markus Wiener, 1998. xvi + 179 pp., Karl Watson (eds)-Virginia Heyer Young, Sheryl L. Lutjens, The state, bureaucracy, and the Cuban schools: Power and participation. Boulder CO: Westview Press, 1996. xiii + 239 pp.

Abstract Background/Aims Filgotinib (FIL), an oral Janus kinase 1 preferential inhibitor, has demonstrated safety and efficacy as treatment for signs and symptoms of RA, and it is approved in Japan and Europe for treatment of RA. Patient characteristics can influence response to RA treatment; this post hoc analysis was performed to determine whether age, body weight (BW), and body mass index (BMI) influenced efficacy. Methods Patients from FINCH 1 (F1, n = 1755, inadequate response to methotrexate [MTX-IR]; NCT02889796) or FINCH 3 (F3, n = 1249, MTX-naïve; NCT02886728) were included for analysis of clinical response at week 12 (F1 primary endpoint) or 24 (F3 primary endpoint). Patients were stratified by age (<65, ≥65 years), BW (<60, 60 to < 100, ≥100 kg), and BMI (<25, ≥25 kg/m2). Efficacy was assessed by ACR20, Disease Activity Score-28 <2.6, Clinical Disease Activity Index ≤2.8, Simple Disease Activity Index ≤3.3, Boolean remission, and change from baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI). Selected efficacy endpoints are displayed in Table 1. Patients treated with FIL200+MTX were compared with control arms (F1, placebo+MTX; F3, MTX). Fisher’s exact test was used for binary endpoints; mixed-effects model for repeated measures was used for HAQ-DI. P-values were nominal without adjusting for multiplicity. Results FIL200+MTX in MTX-IR patients demonstrated greater efficacy vs placebo+MTX regardless of age, BW, and BMI (Table 1). Apart from the ≥65-year-old subgroup, in which there was no clear pattern, FIL200+MTX in MTX-naïve patients demonstrated greater efficacy vs MTX across subgroups (Table 1). Rates of treatment-emergent adverse events (TEAEs) were greater in the ≥65-year-old subgroup vs the <65-year-old subgroup; there was no discernible pattern between BMI subgroups. Among MTX-naïve patients only, rates of TEAEs were higher in those who weighed ≥100 kg vs lower-weight subgroups. Conclusion This exploratory analysis showed FIL200+MTX was efficacious regardless of subgroup characteristics defined by age, BW, or BMI. Most comparisons of FIL200+MTX vs MTX and vs placebo+MTX favored FIL200+MTX. Disclosure Y. Tanaka: Consultancies; Eli Lilly, Daiichi-Sankyo, Taisho, Ayumi, Sanofi, GSK, and AbbVie. Member of speakers’ bureau; Daiichi-Sankyo; Eli Lilly; Novartis; YL Biologics; Bristol-Myers; Eisai; Chugai; AbbVie; Astellas; Pfizer; Sanofi; Asahi-Kasei; GSK; Mitsubishi-Tanabe; Gilead Sciences, Inc.; and Janssen. Grants/research support; AbbVie, Mitsubishi-Tanabe, Chugai, Asahi-Kasei, Eisai, Takeda, and Daiichi-Sankyo. J. Curtis: Grants/research support; from AbbVie, Amgen, BMS, Corrona, Eli Lilly, Janssen, Myriad, Pfizer, Regeneron, Roche, and UCB. S. Wassenberg: Consultancies; AbbVie; Amgen; BMS; Gilead Sciences, Inc.; Eli Lilly; Hexal; MSD; Nichi-Iko; Pfizer; and Sanofi. P. Kiely: Member of speakers’ bureau; Novartis, Lilly, Galapagos, Sobi, Abbvie. L. Ye: Shareholder/stock ownership; Employee and shareholder of Gilead Sciences, Inc. Z. Yin: Shareholder/stock ownership; Employee and shareholder of Gilead Sciences, Inc. B. Downie: Shareholder/stock ownership; Employee and shareholder of Gilead Sciences, Inc. H. Enomoto: Shareholder/stock ownership; former employee/shareholder of Gilead Sciences, Inc. S. Strengholt: Shareholder/stock ownership; shareholder of and employee of Galapagos BV. A. Akhdar: Shareholder/stock ownership; shareholder of and employee of Galapagos BV. C. Watson: Shareholder/stock ownership; shareholder of and employee of Galapagos BV. T. Atsumi: Honoraria; Gilead Sciences, Inc.; Mitsubishi Tanabe; Chugai; Astellas Pharma; Takeda; Pfizer; AbbVie: Eisai; Daiichi Sankyo Co. Ltd.; BMS; UCB Japan Co. Ltd.; Eli Lilly, Otsuka Pharmaceutical Co. Alexion Inc.

<p> </p><p><strong>Vol 5, No 1 May (2015) </strong></p><p>University English: Issues and directions for curriculum development</p><p>Richard Kiely</p><p>01-14</p><p> </p><p>Intercultural communicative competence: A vital skill in the context of ASEAN economic community<br /> Thao Quoc Tran, Tham My Duong<br /> 15-22</p><p> </p><p>Analysis of teachers’ and students’ attitudes toward Iranian senior high school textbook series<br /> Amin Alani, Ali Jahangard<br /> 23-43</p><p> </p><p>Building english vocabulary through roots, prefixes and suffixes</p><p>Metin Yurtbaşı</p><p>44-51</p><p> </p><p>The effect of language proficiency on the negotiation in peer review in EFL context</p><p>Bahram Mowlaie, Parviz Maftoon</p><p>52-64</p><p> </p><p>Teaching lexical chunks on retention and production of referential and collocational meaning of lexis among the Iranian EFL learners<br /> Manochehr Jaafarigohar, Mohsen Nazari<br /> 65-75</p><p> </p><p>Formative assessment in the EFL context of kermanshah high schools: Teachers' familiarity and application<br /> Ferdos Jamali, Nouzar Gheisari<br /> 76-84</p><p> </p><p>The rhetorical organization of research article discussion sections: An investigation into genre evolution in applied linguistics<br /> Alireza Jalilifar, Mitra Baninajar, Soheil Saeedian<br /> 85-100</p><p>The metacognitive awareness listening questionnaire as a metacognitive-raising tool: Does it work?<br /> Rahman Sahragrard, Ali Kushki, M. Miri, Farzad Mahmooudi<br /> 101-113</p><p> </p><p><strong>Vol 5, No 2 November (2015)</strong></p><p><strong> </strong></p><p>From the editors</p><p>Assoc. Prof Dr. Ali Rahimi</p><p><strong> </strong></p><p>EFL teachers’ and learners’ perspectives on “english file series”</p><p><em>Masoud Rahimi</em></p><p><em>115-128</em></p><p> </p><p>Test-Taking strategies and Iranian EFL Learners’ vocabulary and structure test performance</p><p><em>Nouroddin Yousofi, Farkhondeh Pursiah, </em><em>Mohammad Ahmadnejad</em></p><p><em>129-142</em></p><p><em> </em></p><p>Impact of scaffolding on complexity and accuracy of Iranian EFL learners' narrative writing</p><p><em>Rouholah Askari Bigdeli, Ali Rahimi</em></p><p><em>143-156</em></p><p><em> </em></p><p>The effect of social class on Persian EFL learners’ pragmatic performance of Speech act of compliment responses</p><p><em>Saman Ebadi, Farkhondeh Pursiah</em></p><p><em>157-170</em></p><p><em> </em></p><p><em>The impact of self-perception on Iranian EFL learners' oral communication</em></p><p><em>Ali Soltani, Mohsen Ghafari</em></p><p><em>171-176</em></p>

Abstract Background/Aims Filgotinib is an oral, preferential janus kinase 1 inhibitor. FINCH 1 (NCT02889796) was a phase III, double-blind, placebo- and active-controlled study evaluating filgotinib efficacy and safety in patients with rheumatoid arthritis (RA) after inadequate response to methotrexate (MTX; MTX-IR). Methods MTX-IR patients with moderately or severely active RA were randomised (3:3:2:3) to filgotinib 200 mg daily, filgotinib 100 mg daily, adalimumab 40 mg every 2 weeks, or placebo on a background of stable MTX for up to 52 weeks. An exploratory subgroup analysis of FINCH 1 was conducted in patients with moderately active RA based on Disease Activity Score in 28 joints with C-reactive protein (DAS28[CRP])&gt;3.2-≤5.1 at baseline. Proportion of patients achieving 20%/50%/70% improvement from baseline in American College of Rheumatology core criteria (ACR20/50/70), DAS28(CRP)≤3.2, DAS28(CRP)&lt;2.6, change from baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI), Short Form-36 Physical Component Score (SF-36 PCS), patient-reported pain, and modified total Sharp/van der Heijde score (mTSS) were assessed at week (W)12 and W24. All analyses were exploratory without multiplicity adjustment; nominal P-values are reported. Results Of 1,755 treated patients, 24% had moderate disease at baseline with similar proportions (21.9%-26.9%) across treatment groups. In each treatment arm, baseline characteristics were well balanced for the moderate disease activity subpopulation. The majority (77%) were female, mean (standard deviation [SD]) duration of RA was 7.8 (7.7) years; mean (SD) baseline DAS28(CRP) was 4.6 (0.42). At W12 and W24, proportions achieving ACR20/50/70, DAS28(CRP)&lt;2.6, and DAS28(CRP)≤3.2 were significantly higher for both filgotinib doses relative to placebo (Table). Improvement in HAQ-DI was significantly greater vs placebo at W12 but not W24 for both filgotinib doses (Table 1). For both doses of filgotinib vs placebo, SF-36 PCS and pain were significantly improved and there was numerically less radiographic progression as assessed by mTSS at W12 and W24 (Table). Composite disease activity, HAQ-DI, and mTSS scores with both filgotinib doses were comparable to adalimumab. P128 Table 1:Efficacy outcomes at week 12 and week 24Week 12Week 24FIL 200 mg (n = 104)FIL 100 mg (n = 121)ADA (n = 72)PBO (n = 128)FIL 200 mg (n = 104)FIL 100 mg (n = 121)ADA (n = 72)PBO (n = 128)ACR2077.9***67.8***65.343.872.1**75.2***68.154.7ACR5043.3***37.2***41.716.452.9***47.1**56.930.5ACR7019.2***17.4***15.33.932.7***29.8**29.213.3DAS28 (CRP)&lt;2.647.1***37.2***44.415.661.5***46.3***50.023.4DAS28 (CRP)≤3.267.3***63.6***66.739.174.0***73.6***62.549.2ΔHAQ-DI−0.51a,***−0.40b,*−0.47c−0.28d−0.57e−0.53f−0.65g−0.48hΔmTSS0.02i0.06j0.03k0.16l−0.04m,*0.11n−0.01o0.21pΔSF-36 PCS7.8q,***6.4r,***7.0s3.7t8.8u,**7.2v,*9.5w5.8xΔPain, mm−24***−23***−23−12−28***−28***−28−21***P&lt;0.001 vs PBO;**P&lt;0.01 vs PBO;*P&lt;0.05 vs PBO; all P-values are nominal. Binary efficacy endpoints were compared between FIL and PBO using Fisher's exact test. Comparisons of change from baseline between FIL vs PBO were conducted using mixed-effects models for repeated measures including treatment group, visit, treatment group by visit, baseline value as fixed effects, and subjects as random effect.an = 98;bn = 114;cn = 67;dn = 117;en = 89;fn = 108;gn = 61;hn = 100;in = 94;jn = 113;kn = 62;ln = 112;mn = 89;nn = 105;on = 60;pn = 97;qn = 99;rn = 116;sn = 67;tn = 118;un = 91;vn = 109;wn = 62;xn = 100.ΔHAQ-DI, change from baseline in Health Assessment Questionnaire-Disability Index; ΔmTSS, change from baseline in modified total Sharp/van der Heijde score; ΔSF-36 PCS, change from baseline in Short Form-36 Physical Component Score; ACR, American College of Rheumatology; ADA, adalimumab; DAS28(CRP), Disease Activity Score in 28 joints with C-reactive protein; FIL, filgotinib; PBO, placebo. Conclusion In a subgroup of patients from FINCH 1 with baseline moderately active RA, significantly greater improvements in disease activity were observed with both filgotinib doses over placebo and associated with lower radiographic progression and reduced functional deficit. Disclosure M.H. Buch: Consultancies; MHB reports serving as a consultant for AbbVie; Eli Lilly; Gilead Sciences, Inc.; Sandoz; Sanofi; and Serono. Grants/research support; MHB reports grants or research support from Pfizer, Roche, and UCB. D. Walker: Grants/research support; DW has received funding from Bristol-Myers Squibb; Eli Lilly; Gilead Sciences, Inc.; Novartis; and Pfizer, Inc. P.D.W. Kiely: Other; PK has attended advisory boards, been part of a speakers bureau, or received support to attend educational meetings from AbbVie, Gilead, Lilly, Novartis, and Sanofi. C.J. Edwards: Consultancies; CJE has provided consultancy for AbbVie; Biogen; Bristol-Myers Squibb; Celgene; Eli Lilly; Fresenius; Gilead Sciences, Inc.; GSK; Janssen; MSD; Mundipharma; Pfizer; Roche; Samsung; and Sanofi. Member of speakers’ bureau; CJE has served on speaker's bureaus for AbbVie; Biogen; Bristol-Myers Squibb; Celgene; Eli Lilly; Fresenius; Gilead Sciences, Inc.; GSK; Janssen; MSD; Mundipharma; Pfizer; Roche; Samsung; and Sanofi. Grants/research support; CJE reports grants from AbbVie; Biogen; Bristol-Myers Squibb; Celgene; Eli Lilly; Fresenius; Gilead Sciences, Inc.; GSK; Janssen; MSD; Mundipharma; Pfizer; Roche; Samsung; and Sanofi. J. Barry: Corporate appointments; JB is an employee of Gilead Sciences Ltd. G. McCaughey: Corporate appointments; GMcC is an employee of Gilead Sciences Ltd. L. Akroyd: Corporate appointments; LA is an employee of Gilead Sciences Ltd. I. Tiamiyu: Corporate appointments; IT is an employee of Gilead Sciences, Inc. L. Ye: Corporate appointments; LY is an employee of Gilead Sciences, Inc. K. Chen: Corporate appointments; KC is an employee of Gilead Sciences, Inc. P.C. Taylor: Consultancies; PCT has served as a consultant to AbbVie, Biogen, Galapagos, Gilead, GlaxoSmithKline, Janssen, Lilly, Pfizer, BMS, Roche, Sanofi, Nordic Pharma, Fresenius, and UCB. Grants/research support; PCT reports research grants from Gilead Sciences, Inc.; Galapagos, and Celgene.