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Dissertations / Theses on the topic 'Organotypic'

Author: Grafiati

Published: 1 April 2023

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1

Li, Daqing. "Entorhino-hippocampal projections in organotypic cultures." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315340.

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2

Mbobo, Buchule. "Modelling neuroimmune interactions using organotypic slice cultures." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24907.

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Tuberculosis predominantly manifests in the form of a pulmonary infection, but may spread out into other parts of the body and is then referred to as extrapulmonary tuberculosis (EPTB). One form of EPTB is an infection of the central nervous system (brain & spinal cord), CNS-TB. Although CNS-TB is relatively rare, accounting for about 5% of EPTB, it is characterised by high morbidity and mortality, particularly for children and immunosuppressed individuals. To examine the effects of a Mycobacterium tuberculosis infection of neural tissue, researchers have hitherto relied on two animal models n

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3

Steinmeyer, Joseph D. (Joseph Daly). "Rapid single-cell electroporation for labeling organotypic cultures." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/60188.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Vita.<br>Includes bibliographical references (p. 37-39).<br>Single-cell electroporation is a technique for transfecting individual cells in tissue culture at relatively high efficiencies, however it is both time-consuming and low-throughput and this limits the number of different labeling agents that can be effectively introduced into a region of tissue in reasonable periods of time. A novel system that will rapidly load, clean, and accurately position a glass micropipette elect

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4

Vu, Lucas Trung. "Proteomic Analysis of Three Dimensional Organotypic Liver Models." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/77033.

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In vitro liver models that closely mimic the in vivo microenvironment are central for understanding hepatic functions and intercellular communication processes. Bottom-up shotgun proteomic analysis of the hepatic cells can lend insight into such processes. This technique employs liquid chromatography-tandem mass spectrometry (LC-MS/MS) for relative quantification of protein abundances by measuring intensities of their corresponding peptides. Organotypic 3D liver models have been developed in our laboratory that consist of hepatocytes and liver sinusoidal endothelial cells (LSECs) separated by

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5

Kazmi, B. "Oral and dermal fibroblasts in 3D organotypic co-culture." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17485/.

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It is widely observed that dermal wound healing results in the re-establishment of skin continuity through the formation of a scar. In comparison oral wounds heal more rapidly, with less visible scarring. The diverse nature of sub-epithelial fibroblasts has targeted them as mediators for such a distinction in phenotype. Fibroblasts and their differentiated form, the myofibroblast (characterised by the expression of α-SMA), are chief synthesisers of the ECM during wound healing. Myofibroblasts in particular play an important role in wound contracture, ECM synthesis and remodelling during normal

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6

Frantseva, Marina. "H¦2O¦2 induced toxicity in rat organotypic hippocampal cultures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0028/MQ51596.pdf.

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7

Phillips, Wiktor Samuel. "Studies of Respiratory Rhythm Generation Maintained in Organotypic Slice Cultures." W&M ScholarWorks, 2016. https://scholarworks.wm.edu/etd/1499449864.

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Breathing is an important rhythmic motor behavior whose underlying neural mechanisms can be studied in vitro. The study of breathing rhythms in vitro has depended upon reduced preparations of the brainstem that both retain respiratory-active neuronal populations and spontaneously generate respiratory-related motor output from cranial and spinal motor nerves. Brainstem-spinal cord en bloc preparations and transverse medullary slices of the brainstem have greatly improved the ability of researchers to experimentally access and thus characterize interneurons important in respiratory rhythmogenesi

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8

Jussila, T. (Tommi). "Modelling cancer: recapitulation of tumor growth in experimental systems in vivo and in vitro." Doctoral thesis, University of Oulu, 2000. http://urn.fi/urn:isbn:9514256433.

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Abstract The purpose of the study was to evaluate model systems of cancer development and compare some of their critical features with cancer development in vivo. Ovarian and endometrial cancers in man were used as correlates. Tumor development in experimental animals, exposed to carcinogens and UV irradiation, showed the entire spectrum of tumor development as compared to spontaneous carcinomas: hyperplasia, dysplasia, benign papillomas and malignant squamous cell carcinomas. For short-term analysis of differentiated homogenous cell populations, the transplant model proved most useful

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9

Acheva, Anna Rumenova. "Mechanisms of response to targeted irradiation in organotypic 3D skin cultures." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579565.

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Low linear energy transfer (LET) ionizing radiation as gamma and X-rays is widely used in the modem medicine for diagnostic and treatment purposes. Despite all the advantages that it gives for the early diagnosis and in the radiotherapy treatment of cancer, there are still unclear aspects about the mechanisms of the radiation effects in human tissue. Of particular interest is the detailed pathway which the directly irradiated cells use to communicate to their neighbours and its possible implications for radiotherapy applications. The aim of this project is to study the spatio-temporal signalli

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10

Froeling, Fieke E. M. "Tumour–stroma interactions in an organotypic culture model of pancreatic cancer." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/705.

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Pancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the complex in vivo situation. The aim of my project was to develop a physiologically relevant, three-dimensional organotypic culture model of pancreatic cancer to study the tumour-stroma interactions and its modulation by novel therapeutic agents. Cancer cells cultured on top of collagen/Matrigel gels, embedded with or without stromal cells (hTERT immortalised

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11

Fell, Benjamin. "Organotypic human skin disease models for the assessment of novel therapeutic approaches." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24594.

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Comprehensive in vitro modelling of inflammatory human skin conditions is an essential first step in the development and assessment of potential therapeutic approaches. Mouse models or monolayer keratinocyte cultures come with distinct limitations which might be complimented or overcome by the use of human-specific organotypic 3D culture models. Over the course of this thesis, an organotypic culture system, based on patientderived immortalised keratinocyte cell lines on a dermal equivalent collagen 1 gel, was established and used to recapitulate phenotypical features for two hereditary skin di

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12

Rioult-Pedotti, Marc Guy. "Optical multisite recording of neural activity patterns in organotypic spinal cord tissue cultures /." [S.l.] : [s.n.], 1991. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=9393.

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13

Ajani, Gati. "Characterization of changes in hyaluronan following epidermal barrier injury in an organotypic model." Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1209996841.

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Thesis (D.Eng.)--Cleveland State University, 2008.<br>Abstract. Title from PDF t.p. (viewed on July 7, 2008). Includes bibliographical references (p. 150-176). Available online via the OhioLINK ETD Center. Also available in print.

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14

El-Tarhouni, Amal Ibrahium. "Studies on the mechanosensory innervation of muscle using organotypic culture, reinnervation and immunohistochemistry." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5266/.

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This thesis studies sensory innervation in mammals using an organotypic co-culture of spinal cord-dorsal root ganglion and skeletal muscle of embryonic rat, the histological changes of reinnervated muscle spindles after nerve section and the localisation of the calcium-binding protein calretinin in cat mechanoreceptor organs. The immediate importance of this project concerns the better understanding of how the normal process of development differs from reinnervation following nerve lesion or section. A range of classical and well defined materials and methods as been used in the work described

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15

Gronbach, Leonie [Verfasser]. "Organotypic head and neck cancer models for advanced preclinical drug testing / Leonie Gronbach." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1230407316/34.

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16

Medelin, Manuela. "Degenerative processes in organotypic spinal slices: challenging pre-motor network with stress conditions." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/10130.

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2012/2013<br>My PhD project concerns neurodegenerative processes in the mouse spinal cord, with a particular attention to amyotrophic lateral sclerosis (ALS). During my PhD I have used as a model the organotypic spinal slice cultures and I have focused my studies on: early changes in spinal tissue excitability in an ALS genetic model; spinal network activity changes induced by oxidative stress in wild type (WT) and synaptic activity in premotor circuits when challenged by neuroinflammation in WT. The principal aim of my work was to understand the dialogue between a general stress condition and

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17

Patel, Leena Suman. "Functional changes in pyramidal neurons surviving an excitotoxic challenge in mouse organotypic slice cultures /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10658.

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18

Isaacson, Erin. "Understanding the molecular basis of HPV-16 neoplastic progression using an organotypic raft model." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522239.

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19

Meng, Weina. "Evaluation of a nanoparticle drug delivery vehicle in medulloblastoma and organotypic brain cell cultures." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/13933/.

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It has been widely reported that cell culture dimension and microenvironment influence cell proliferation, differentiation, and gene expression, which lead to different interactions between drug delivery systems and cells. The development in evaluation of drug delivery systems has reached the stage where investigations are now concentrating on intracellular uptake and subcellular localization of drug delivery systems.This thesis investigates the use of three-dimensional (3-D) tissue culture models to study how nanoparticles (NPs) may behave in vivo. Poly (glycerol-adipate) (PGA) NPs can degrad

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20

Orbach, Sophia Michelle. "Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/93313.

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The liver is responsible for lipid and glucose metabolism, protein and bile synthesis and the biotransformation of xenobiotics. These functions, performed by hepatocytes, are dependent on heterotypic interactions with other liver cell types and the stratified microarchitecture of the organ. In vitro liver models provide insights into the role of each cell type and perturbations upon external stimuli. Despite the dissimilarities to in vivo and rapid dedifferentiation, most liver studies utilize hepatocyte monocultures. These models lack heterotypic interactions causing inaccurate assessments of

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21

Croft, Cara Louise. "Investigating the mechanisms underlying Alzheimer's disease using a novel organotypic brain slice culture model." Thesis, King's College London (University of London), 2016. http://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-mechanisms-underlying-alzheimers-disease-using-a-novel-organotypic-brain-slice-culture-model(321a7046-c8e8-4c42-9abf-01792be7870c).html.

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Alzheimer's disease is a devastating progressive neurodegenerative disorder characterised by deposits of amyloid-β in extracellular plaques, intracellular neurofibrillary tangles comprising highly phosphorylated and aggregated tau species, synaptic dysfunction and neuronal death. Although several transgenic mouse models of Alzheimer's disease have been developed, in vivo studies using transgenic mice are time- and cost- consuming, and it is imperative that more ethically sustainable alternatives, which allow faster translation to the clinic, are developed. This thesis aims to determine if orga

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22

Studer, Lorenz. "NGF increases neuritic complexity of cholinergic interneurons in organotypic cultures of neonatal rat striatum /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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23

Cocchi, M. A. "THE MELATONIN PROTECTIVE ROLE IN AN ORGANOTYPIC MODEL OF SPINAL CORD INJURY SECONDARY DAMAGE." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/351674.

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Spinal cord injury (SCI) is characterized to be a two-step process composed by the primary lesion consisting of the initial trauma and the secondary damage, characterized by multiple processes including inflammation, oxidative stress and cell death that lead to a significant expansion of the original damage and to an increase of the functional deficit. Among the aforementioned processes, the oxidative stress plays a significant role in pathophysiology of SCI. In this study, we evaluated the role of melatonin, potent antioxidant and immunomodulator indoleamin, on the oxidative stress, the tissu

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24

Ireland, Kirsty Anne. "Development of whole brain organotypic slice culture to investigate in vitro seeding of amyloid plaques." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28707.

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A feature of prion disease and other protein misfolding neurodegenerative disease is the formation of amyloid plaques. Amyloid is commonly found in the brain of individuals who have died from prion disease and Alzheimer’s disease. The formation and purpose of amyloid in such diseases is poorly understood and it is not currently known whether the material is neurotoxic, neuroprotective or an artefact. Several methods are used to investigate the formation of amyloid both in vitro and in vivo. A cell free protein conversion assay has been optimised to gain insight into the protein misfolding path

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25

Bonilla-Pons, Sergi A. "Setting up stem cell therapy for human retina: from organotypic cultures to cell fusion understanding." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673448.

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Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, show regenerative potential for the retina, however in the mammals this capacity is lost. However, it has been demonstrated in mice that fusion between MGCs and adult stem cells result in the formation of hybrids which detain some potential to regenerate the lost retinal neurons. In the present work we hypothesize that also into the human retina cell fusion between adult stem cells and

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26

Singh, Sunil. "Engineered Organotypic Breast Tumor Model for Mechanistic Studies of Tumor-Stromal Interactions and Drug Discovery." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1616940345310981.

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27

CAMBINI, AIMONE. "Effetti della biostimolazione laser sul tessuto epiteliale per il differenziamento dello strato cheratinizzato: studio in vitro." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/43489.

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Background: The overall view of gingival augmentation techniques proposed in the international literature does not exclude a surgical component. The planning of one or more surgical phases with the consequent post-surgical discomfort and results not always predictable are required when setting up periodontal flaps combined eventually with free gingival grafts. The introduction in the last years of laser biostimulation has led to a less invasive approach, particularly in the treatment of periodontally compromised patients, limiting the surgical phase to seriously compromised cases, with regener

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28

Vautrin, Sandrine. "Investigating oligodendrocyte development and stability using organotypic hippocampal slices, confocal imaging and viral gene delivery methods." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111543.

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Myelin plays an essential function in the behaviour of higher organisms by increasing the speed of axonal conduction. Indeed, myelin deficiency or damage can lead to serious motor and sensory dysfunction. In the central nervous system, myelin is produced by a specialized macroglial cell known as the oligodendrocyte. Although much is known about oligodendrocytes with respect to their role in myelin production, many details regarding their development and maintenance still remain unclear. These details may be of great importance for fully understanding the fundamental properties of oligodendrocy

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29

Smith, Donna Louise. "An organotypic slice culture assay to assess huntingtin aggregation in Huntington's disease R6/2 transgenic mice." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406704.

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30

Athar, Saira. "Immortalization of human oral keratinocytes with defined genetic elements in the development of organotypic oral culture." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8690.

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Primary cell culture is limited by the increase in cellular levels of p16INK4a in response to an in vitro culture environment and, in conjunction with telomere shortening following cell division, presents a barrier to cellular proliferation. The use of transformed cell lines is limited for studies wherein the aim is to generate data akin to an in vivo environment as commonly such cell lines achieve their immortal benefits by down regulating important tumour suppressive mechanisms and inhibiting cell cycle checkpoints. Normal Human Oral Keratinocyte (NHOK) cells expressing shp16+hTERT were gene

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31

Dallacasagrande, Valentina. "Novel approaches to study the biomechanics of intact central nervous tissue." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-163943.

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In nature, cells are not randomly clustered to form tissues. The tissue is a more complicated system with functions that go beyond what any single cell type could accomplish. While studying single-cell mechanics and dynamics is relevant from an investigative point of view, this approach loses, or fail to gather information about the tissue. The tissue investigated in this study is the neurosensory retina which seeing as extension of the brain is a very convenient model for the central nervous system due to its accessibility. The retina is constantly subjected to different mechanical stresses f

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32

McBain, Christopher J. "An electrophysiological investigation of the spontaneously arising epileptiform activity seen in organotypic cultures of neonate rat hippocampus." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293815.

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33

Stubblefield, Park Samantha Renee. "Organotypic brain explants reveal an interleukin-12 / interferon-γ / T-cell dependent clearance of measles virus infection". Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1297280439.

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34

Sullivan, Aideen Margaret. "The use of organotypic cultures of rat cerebellum for the study of neuromodulatory interactions in the mammalian brain." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243197.

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35

Jagger, Elizabeth. "The effects of kainic acid in hippocampal organotypic cultures : a chronic in vitro model of temporal lobe epilepsy." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269697.

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36

Barnhart, Kirstin Faye. "In vitro and in vivo analysis of differential gene expression between normal norfolk terrier dogs and those with an autosomal recessive mutation in KRT10." Texas A&M University, 2004. http://hdl.handle.net/1969.1/2671.

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Natural diseases caused by keratin mutations are rare and have only been reported in humans. We have recently identified a heritable skin disorder in Norfolk terriers caused by a mutation in KRT10. Affected dogs have a tendency to form shallow erosions or blisters following mild trauma, which is first noted after the birthing process. As the dogs age, they display generalized hyperpigmentation and scaling that is most severe in the axillary and inguinal regions. The main histologic and ultrastructural features include: marked hyperkeratosis, epidermal hyperplasia, prominent vacuolation of the

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37

Wills, Lauren Raquel. "Investigating Induced Pluripotent Stem Cells for Tissue Engineering and Hepatotoxicity Applications." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/101006.

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Induced pluripotent stem cells (iPSCs) can be differentiated into multiple cell types in the body while maintaining proliferative capabilities. The generation of human iPSC-derived hepatocytes (iPSC-Heps) has resulted in a new source for hepatic cells. The current available options for human hepatocytes are primary human hepatocytes (PHHs) and cell lines. PHHs isolated from healthy human donors are difficult to obtain, while cell lines exhibit reduced hepatotoxic sensitivity. iPSC-Heps are being investigated as an alternative option as they are derived from a continuous, stable source and

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38

Werner, Renata Verfasser], та Mathias [Akademischer Betreuer] [Jucker. "Modeling the prion aspect of cerebral β-amyloidosis in organotypic slice cultures and mice / Renata Werner ; Betreuer: Mathias Jucker". Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1168728371/34.

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Jevtić, Marijana [Verfasser]. "Fine-Tuning of Organotypic Skin Equivalents for Preclinical Research and Their Utilization to Study Epidermal-Dermal Crosstalk / Marijana Jevtić." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1229436650/34.

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Nash, Claire. "Development of an organotypic 3D in vitro model of normal human breast tissue : a tool for cancer initiation studies." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/6845/.

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The mechanisms involved in breast cancer initiation are not well understood. This may in part be due to a lack of an in vitro model that faithfully recapitulates the morphology, phenotype and in vivo architecture of the normal human mammary gland. Most in vitro models of normal breast have relied on the use of reconstituted basement membrane gels to induce luminal epithelial cell polarity and have neglected the role of myoepithelial cells and fibroblasts in this process. The aim of this thesis was to develop a three dimensional in vitro culture system of normal breast which included three of t

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Müller, Mareike [Verfasser], Horst-Werner [Akademischer Betreuer] Korf, Horst [Akademischer Betreuer] Stöcker, and Marco [Akademischer Betreuer] Durante. "Effects of ionizing radiation on organotypic slice cultures / Mareike Müller. Gutachter: Horst Stöcker ; Marco Durante. Betreuer: Horst-Werner Korf." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2013. http://d-nb.info/104397816X/34.

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Olivieri, Dario. "New Spinal cord models: Characterization of Excitotoxicity and Neuroprotection." Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/3892.

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Group III metabotropic glutamate receptors (mGluR III) are known to decrease glutamate release and to play an important role in controlling pain as documented in neuropathic pain models. Much less is known about their potential neuroprotective effect against excitotoxicity that is considered important for damage onset of spinal cord injury. Using rat spinal cord organotypic slices model, we investigated if mGluR III receptor activation might contrast excitotoxic cell death evoked by kainic acid (0.1 mM) applied for 1h and followed by wash for further 24h. The specific agonist of mGluR III rece

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Sygnecka, Katja. "Organotypic brain slice co-cultures of the dopaminergic system - A model for the identification of neuroregenerative substances and cell populations." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-188897.

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The development of new therapeutical approaches, devised to foster the regeneration of neuronal circuits after injury and/or in neurodegenerative diseases, is of great importance. The impairment of dopaminergic projections is especially severe, because these projections are involved in crucial brain functions such as motor control, reward and cognition. In the work presented here, organotypic brain slice co-cultures of (a) the mesostriatal and (b) the mesocortical dopaminergic projection systems consisting of tissue sections of the ventral tegmental area/substantia nigra (VTA/SN), in combinati

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Barth, Melanie [Verfasser]. "Organotypic slice culture models for induced alpha-synucleinopathy and exploration of the potential role of microglia in pathogenesis / Melanie Barth." Tübingen : Universitätsbibliothek Tübingen, 2023. http://d-nb.info/1238595006/34.

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45

Aldarwesh, Amal. "Oxygen and glucose deprivation on human Müller cells (MIO-M1) and human organotypic retinal cultures (HORCs) in relation to glaucoma." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/58555/.

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Purpose: The purpose of this research was to investigate the effect of glaucoma-related insults, specifically oxygen and/or glucose deprivation (OGD) on the survival and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to different levels of OGD using a custom-built chamber to control oxygen levels. Cell survival was evaluated using MTS and LDH assays while RGC death in HORCs was investigated using NeuN immunohistochemistry and TUNEL-labelling. Expression of

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Linnemann, Jelena [Verfasser], and Magdalena [Akademischer Betreuer] Götz. "An organotypic assay for the quantification and characterization of regenerative primary human mammary epithelial cells / Jelena Linnemann ; Betreuer: Magdalena Götz." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1154683699/34.

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Niel, Olivier. "Développement vasculaire rénal in vivo et ex vivo : vers la bio-ingénierie rénale." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4023.

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Chez la souris, la néphrogenèse débute par l'apparition du blastème metanéphrogène à 9.5 dpc. Une transition mésenchymo-épithéliale, comportant 5 étapes, débute a 11.5 dpc et aboutit au rein mature, composé de 3 structures : glomérules, tubules, et capillaires glomérulaires. Les étapes initiales du développement rénal peuvent être récapitulées en culture ex vivo; toutefois, l'organogenèse terminale et la maturation rénale sont incomplètes, et les structures rénales obtenues ex vivo ne sont pas fonctionnelles. Une étude du développement vasculaire in vivo au cours du développement rénal montre

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Wang-Lauenstein, Lan [Verfasser]. "Assessment of chemical-induced local irritation and inflammation in organotypic lung tissue model : precision-cut lung slices (PCLS) / Lan Wang-Lauenstein." Hannover : Technische Informationsbibliothek (TIB), 2017. http://d-nb.info/1128673576/34.

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49

Verheyen, Leonie Katharina [Verfasser]. "Development of Organotypic Skin Disease Equivalents Mimicking Hallmarks of Atopic Dermatitis for Basic Research and Preclinical Drug Evaluation / Leonie Katharina Verheyen." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176641182/34.

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Schmohl, Michael [Verfasser], and Stefan [Akademischer Betreuer] Stevanovic. "Analyzing biological activity of drugs- Inter- and intracellular signaling analysis within an organotypic co-culture system / Michael Schmohl ; Betreuer: Stefan Stevanovic." Tübingen : Universitätsbibliothek Tübingen, 2011. http://d-nb.info/1162699302/34.

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