Relevant bibliographies by topics / Organotropisme

Academic literature on the topic 'Organotropisme'

Author: Grafiati
Published: 30 June 2023

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Journal articles on the topic "Organotropisme"

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Wei, Shi, and Gene P. Siegal. "Metastatic Organotropism." Advances In Anatomic Pathology 24, no. 2 (March 2017): 78–81. http://dx.doi.org/10.1097/pap.0000000000000140.

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Yuzhalin, Arseniy E., and Dihua Yu. "Brain Metastasis Organotropism." Cold Spring Harbor Perspectives in Medicine 10, no. 5 (September 23, 2019): a037242. http://dx.doi.org/10.1101/cshperspect.a037242.

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Lu, Xin, and Yibin Kang. "Organotropism of Breast Cancer Metastasis." Journal of Mammary Gland Biology and Neoplasia 12, no. 2-3 (June 14, 2007): 153–62. http://dx.doi.org/10.1007/s10911-007-9047-3.

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Fu, Hongmei, Eleanor Jayne Ward, and Federica M. Marelli-Berg. "Mechanisms of T cell organotropism." Cellular and Molecular Life Sciences 73, no. 16 (April 1, 2016): 3009–33. http://dx.doi.org/10.1007/s00018-016-2211-4.

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Gao, Yang, Igor Bado, Hai Wang, Weijie Zhang, Jeffrey M. Rosen, and Xiang H. F. Zhang. "Metastasis Organotropism: Redefining the Congenial Soil." Developmental Cell 49, no. 3 (May 2019): 375–91. http://dx.doi.org/10.1016/j.devcel.2019.04.012.

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Keller, Georg v. "Chelidonium und die Organotropie." Allgemeine Homöopathische Zeitung 224, no. 06 (April 10, 2007): 217–27. http://dx.doi.org/10.1055/s-2006-935880.

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Schmeer, Ernst H. "Rademacher und die Organotropie." Allgemeine Homöopathische Zeitung 225, no. 03 (April 10, 2007): 115–19. http://dx.doi.org/10.1055/s-2006-935894.

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Tang, Kai, Ying Xin, Keming Li, Xi Chen, and Youhua Tan. "Cell Cytoskeleton and Stiffness Are Mechanical Indicators of Organotropism in Breast Cancer." Biology 10, no. 4 (March 25, 2021): 259. http://dx.doi.org/10.3390/biology10040259.

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Tumor metastasis involves the dissemination of tumor cells from the primary lesion to other organs and the subsequent formation of secondary tumors, which leads to the majority of cancer-related deaths. Clinical findings show that cancer cell dissemination is not random but exhibits organ preference or organotropism. While intrinsic biochemical factors of cancer cells have been extensively studied in organotropism, much less is known about the role of cell cytoskeleton and mechanics. Herein, we demonstrate that cell cytoskeleton and mechanics are correlated with organotropism. The result of cell stiffness measurements shows that breast cancer cells with bone tropism are much stiffer with enhanced F-actin, while tumor cells with brain tropism are softer with lower F-actin than their parental cells. The difference in cellular stiffness matches the difference in the rigidity of their metastasized organs. Further, disrupting the cytoskeleton of breast cancer cells with bone tropism not only elevates the expressions of brain metastasis-related genes but also increases cell spreading and proliferation on soft substrates mimicking the stiffness of brain tissue. Stabilizing the cytoskeleton of cancer cells with brain tropism upregulates bone metastasis-related genes while reduces the mechanoadaptation ability on soft substrates. Taken together, these findings demonstrate that cell cytoskeleton and biophysical properties of breast cancer subpopulations correlate with their metastatic preference in terms of gene expression pattern and mechanoadaptation ability, implying the potential role of cell cytoskeleton in organotropism.
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Eng, Jennifer, Jason Link, Carl Pelz, and Rosalie Sears. "Abstract PR010: Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma." Cancer Research 83, no. 2_Supplement_2 (January 15, 2023): PR010. http://dx.doi.org/10.1158/1538-7445.metastasis22-pr010.

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Abstract PDAC patients have a dismal prognosis with an 11% 5-year survival rate, driven in part by the fact that 90% of patients are diagnosed with metastatic disease. In a cohort of 300 PDAC patients, we observed that patients who had lung-only metastasis had longer overall survival than the majority of patients with metastasis to the liver. We used gene expression data to develop a signature based on gene expression in primary tumors of liver versus lung organotropism, which we called pORG. Our pORG signature predicts long term survival in PDAC patients and reveals unique features of the primary tumor, including increased interferon and immune activity in lung tropic tumors and increased proliferation and replication stress in liver-tropic tumors. To validate our findings, we generated cyclic immunofluorescence multiplex imaging data for a subset of 34 patients. Single cell image analysis revealed B and T cell infiltration and spatial clustering in low pORG/ lung tropic tumors, and markers of replication stress in high pORG patients. Our work suggests unique targetable tumor and microenvironment features linked to organotropism in PDAC. Citation Format: Jennifer Eng, Jason Link, Carl Pelz, Rosalie Sears. Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr PR010.
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Wong, Grace L., Sara Abu Jalboush, and Hui-Wen Lo. "Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis." Cancers 12, no. 7 (July 7, 2020): 1827. http://dx.doi.org/10.3390/cancers12071827.

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Breast cancer is the most frequent malignancy for women in which one in eight women will be diagnosed with the disease in their lifetime. Despite advances made in treating primary breast cancer, there is still no effective treatment for metastatic breast cancer. Consequently, metastatic breast cancer is responsible for 90% of breast cancer-related deaths while only accounting for approximately one third of all breast cancer cases. To help develop effective treatments for metastatic breast cancer, it is important to gain a deeper understanding of the mechanisms by which breast cancer metastasizes, particularly, those underlying organotropism towards brain, bone, and lungs. In this review, we will primarily focus on the roles that circulating exosomal microRNAs (miRNAs) play in organotropism of breast cancer metastasis. Exosomes are extracellular vesicles that play critical roles in intercellular communication. MicroRNAs can be encapsulated in exosomes; cargo-loaded exosomes can be secreted by tumor cells into the tumor microenvironment to facilitate tumor–stroma interactions or released to circulation to prime distant organs for subsequent metastasis. Here, we will summarize our current knowledge on the biogenesis of exosomes and miRNAs, mechanisms of cargo sorting into exosomes, the exosomal miRNAs implicated in breast cancer metastasis, and therapeutic exosomal miRNAs.
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Dissertations / Theses on the topic "Organotropisme"

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Minet, Antoine. "Bioaccumulation and effects of mercury in cuttlefish in the context of ocean acidification." Electronic Thesis or Diss., La Rochelle, 2022. http://www.theses.fr/2022LAROS039.

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La seiche commune, Sepia officinalis, est un céphalopode côtier connu pour ses performances écophysiologiques soutenues par un large répertoire de comportements lui permettant, malgré son cycle de vie court, de tenir un rôle central dans les réseaux trophiques. Cependant, elle est également connue pour accumuler efficacement les éléments métalliques tel que le mercure (Hg), un contaminant neurotoxique sous sa forme organique (methylmercure ; MeHg). De plus, dans le contexte des changements environnementaux globaux, l’acidification des océans (AO) induite par l’augmentation des émissions de CO2, peut impacter le métabolisme, le développement et le système nerveux central, notamment chez les jeunes stades de vie. Le présent travail a donc pour but d’étudier les effets de l’AO sur la bioaccumulation du Hg et les effets de ces deux neurotoxiques (Hg et CO2) sur le comportement et les performances cognitives chez les juvéniles de seiches. Préalablement, des mesures in-situ ont montré que le Hg s’accumulait dans le cerveau des céphalopodes sous forme méthylé (MeHg). Par ailleurs, les approches expérimentales utilisant des traceurs isotopiques (stables et radioactif) du Hg ont démontré que l’accumulation du Hg total provenait majoritairement de l’assimilation du MeHg présent dans les proies, en comparaison à l’accumulation du mercure inorganique (iHg) par voie dissoute. Ce MeHg est ensuite très fortement retenu malgré la mise en évidence de processus de déméthylation du Hg dans la glande digestive. Étonnamment, l’AO n’a aucun effet sur les efficacités de la bioaccumulation et le métabolisme du Hg. En termes d’effets, des essais comportementaux ont montré que le Hg et CO2, seuls ou combinés, n’impactaient pas l’acuité visuelle et les performances de prédation chez les juvéniles. Par contre, ces deux derniers induisent une augmentation de l’activité locomotrice, compromettant le comportement défensif à travers notamment une altération de la coloration disruptive et un non-alignement de la latéralisation. Parmi les processus neuronaux susceptibles d’être impactés par le Hg et le CO2, le système GABAergique a été analysé dans les lobes optiques mais n’a montré aucun lien évident avec les réponses comportementales suggérant des processus d’effets plus complexes. L’ensemble de ce travail questionne donc les effets des conditions futures de l’océan sur les juvéniles de seiches, et plus largement les impacts sur les populations de céphalopodes
The common cuttlefish, Sepia officinalis, is a coastal cephalopod known for its eco physiological performance supported by a wide repertoire of behaviors that allows it, despite its short life cycle, to play a central role in food webs. However, it is also known to efficiently accumulate metallic elements such as mercury (Hg), a neurotoxic contaminant in its organic form (methylmercury; MeHg). Moreover, in the context of global changes, ocean acidification (OA) induced by the increase of CO2 emissions, can impact metabolism, development and the central nervous system, especially in young life stages. The present work therefore aims to study the effects of OA on Hg bioaccumulation and the effects of these two neurotoxicants (Hg and CO2) on behavior and cognitive performance in juvenile cuttlefish. In the first place, in-situ measurements showed that Hg accumulated in the brain of cephalopods in methylated form (MeHg). Moreover, experimental approaches using isotopic tracers (stable and radioactive) of Hg have shown that the accumulation of total Hg comes mainly from the assimilation of MeHg present in preys, compared to the accumulation of inorganic mercury (iHg) dissolved in seawater. This MeHg is then very strongly retained despite evidence of Hg demethylation processes in the digestive gland. Surprisingly, OA has no effect on the bioaccumulation efficiencies and metabolism of Hg. In terms of effect, behavioral assays showed that Hg and CO2, alone or in combination, did not impact visual acuity and predation performance in juveniles. However, both induced an increase in locomotor activity, compromised defensive behavior through, in particular, an alteration of disruptive coloration and a non-alignment of lateralization. Among the neural processes likely to be impacted by Hg and CO2, the GABAergic system was analyzed in the optic lobes but showed no obvious link with behavioral responses suggesting more complex effect processes. All of this work therefore questions the effects of future ocean conditions on juvenile’s cuttlefish, and more broadly the impacts on cephalopod populations
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Ham, Sunyoung. "The role of breast cancer derived-exosomes in the tumour micro-environment." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/208432/1/Sunyoung_Ham_Thesis.pdf.

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The findings in this thesis demonstrate that cancer-derived exosomes play a critical role in the tumour microenvironment, which greatly expands our understanding of the mechanisms underlying cancer progression and metastasis. This research provides novel approaches at allowing improved utilisation of cancer-derived exosomes as diagnostic biomarker tools or for therapeutic interventions for cancer treatment.
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Carvalho, António. "Tackling Metastasis with Gold Nanoparticles: Inhibition of Intercellular Communication Mediated by Cancer Cells-Derived Exosomes." Master's thesis, 2022. http://hdl.handle.net/10362/133583.

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Metastases are accountable for at least 66.7% of cancer deaths, implying a terminal illness for the great majority of patients diagnosed with metastatic cancer. The last and rate-limiting step in invasion-metastasis cascade is colonization. Colonization is the process by which disseminated tumour cells penetrate distant tissues and adapt to the foreign “soil” in order to prosper. To hasten colonization, cancer cells often secrete soluble factors and extracellular vesicles such as exosomes through systemic circulation, which ultimately lead to creation of tumour permissive microenvironments at secondary organs, pre-metastatic niches. Exosomal integrins α6β1 and α6β4 secreted by MDA-MB-231 cells, a human breast cancer cell line, were found to specifically fuse with lung-resident fibroblasts and epithelial cells. The cargo release within recipient cells activates Src and upregulates pro-inflammatory S100 genes, which generates lung pre-metastatic niches and promotes lung tropic metastasis. In this case, cell-cell communication via exosomes between primary tumour cells and microenvironment of distant organs is a key mediator of metastasis progression. Taken into account the recent bet on antisense oligonucleotides therapeutics and the advent of nanotechnology, a gold-nanoconjugate with gene silencing activity was produced. This was achieved by functionalizing gold nanoparticles with an antisense oligonucleotide designed to silence ITGA6, the gene that encodes the α6 subunit, present in integrins α6β1 and α6β4. The silencing efficacy was evaluated using MDA-MB-231 cells at the RNA and protein levels, and the existence of phenotypical changes between untreated and treated cells was assessed. The nanoconjugate showed silencing activity. Reduced cellular levels of integrins α6β1 and α6β4 may lead to diminished packaging of these receptors into exosomes and impairment of integrin-mediated lung tropic metastasis. This nanoscale approach has potential to be employed to prevent lung metastasis, but further studies are required.
Pelo menos 66.7% das mortes por cancro são atribuídas à presença de metástases, implicando uma doença terminal para a grande maioria dos pacientes diagnosticados com cancro metastático. O passo limitante da cascata de invasão-metastização é o último passo, a colonização. A colonização é o processo pelo qual células tumorais disseminadas penetram tecidos distantes e se adaptam a “solo” desconhecido de modo a prosperar. Para acelerar o processo de colonização, as células cancerígenas libertam frequentemente fatores solúveis e vesículas extracelulares como os exossomas através da circulação sistémica, o que conduz à criação de microambientes permissivos ao desenvolvimento tumoral noutros órgãos, os nichos pré-metastáticos. Descobriu-se que as integrinas exossomais α6β1 e α6β4, libertadas por células do cancro da mama, se ligam especificamente a fibroblastos e células epiteliais residentes nos pulmões. A libertação do conteúdo exossomal nas células recetoras ativa a proteína Src e aumenta a expressão dos genes pro-inflamatórios S100. Esta interação leva à formação de nichos pré-metastáticos no pulmão e promove a metastização com tropismo para o pulmão. Neste caso, a comunicação célula-célula via exossomas entre o tumor primário e microambientes de órgãos distantes é o mediador chave da progressão metastática. Tendo em conta a recente aposta nas terapêuticas de oligonucleótidos antisense e o advento da nanotecnologia, foi produzido um nanoconjugado de ouro com atividade de silenciamento génico. Isto foi alcançado através da funcionalização de nanopartículas de ouro com um oligonucleótido antisense desenhado para silenciar ITGA6, o gene que codifica para a subunidade α6 das integrinas α6β1 e α6β4. A eficácia do silenciamento foi avaliada ao nível do RNA e da proteína usando células MDA-MB-231, e foi verificada também a existência de alterações fenotípicas entre células tratadas e não tratadas. O nanoconjugado demonstrou atividade de silenciamento génico. A redução dos níveis de integrinas α6β1 e α6β4 pode levar à diminuição do empacotamento destes recetores nos exossomas e travar a metastização com tropismo para o pulmão mediada por integrinas. Esta estratégia à nanoescala tem potencial para ser utilizada para prevenir a metastização nos pulmões, mas são necessários mais estudos.
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Book chapters on the topic "Organotropisme"

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Thiery, J. P. "Metastasis: Adhesion, Lectin-Carbohydrate Interaction, Organotropism, Growth Factors." In Cancer Metastasis, 216–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74236-1_28.

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Schirrmacher, V., A. Kowitz, G. Kadmon, R. Benke, and P. Altevogt. "Change in metastasis and organotropism of mouse lymphoma variants associated with changes in expression of adhesion molecules and chemotactic responsiveness." In Lectins and Cancer, 171–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76739-5_12.

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"Organotropism." In Encyclopedia of Parasitology, 2014. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_2239.

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Stock, Christian. "Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?" In Reviews of Physiology, Biochemistry and Pharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/112_2021_68.

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Conference papers on the topic "Organotropisme"

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Zhong, Yi, Jun Fan, Jinlong Huang, and Christine A. Iacobuzio-Donahue. "Abstract 2829: Identification of transcriptomic signatures of organotropism in pancreatic cancer metastasis." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2829.

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Ge, William H., Giuseppe Tarantino, Emily Robitschek, Michael P. Manos, Lauren Eastman, Olivia Ouyang, Patrick Ott, et al. "Abstract 2846: Stereotypic patterns and genomic correlates of organotropism in metastatic melanoma." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2846.

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Mahal, Katharina, Kelly Brooks, Amit Mandal, Matthew Smith, Nathalie Dhomen, and Richard Marais. "Abstract 4844: CRISPR-generated BAP1 knockdown in uveal melanoma cell lines affects organotropism." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4844.

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Lyden, DC, H. Peinado-Selgas, A. Nitadori, T.-L. Shen, M. Aleckovic, Y. Kang, and J. Bromberg. "Abstract BS03-1: Tumor-derived exosomes promote pre-metastatic niche formation and organotropism." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-bs03-1.

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Nguyen, Bastien, Christopher Fong, Renzo DiNatale, Anisha Luthra, Subhiksha Nandakumar, Henry Walch, Walid K. Chatila, et al. "Abstract 2834: Integration of genomic and clinical data from 25,000 patients identifies molecular determinants of metastatic potential and organotropisms." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2834.

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Didmanidze, Ibraim, and Irma Bagrationi. "INFORMATION PARADIGMS OF ART FROM THE HISTORY OF SOCIAL AESTHETICS." In 9th SWS International Scientific Conferences on ART and HUMANITIES - ISCAH 2022. SGEM WORLD SCIENCE, 2022. http://dx.doi.org/10.35603/sws.iscah.2022/s07.06.

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The present scientific paper deals with the worldview understanding of features of information and communication functions of art according to the �Theory of Environment� and �Conception of Organotropism� from the history of Europeanworldview philosophical and aesthetic thought, particular: According to the main principle of Social Aesthetics of French philosopher and sociologist Jean-Marie Guyau [in the work �Problems of Contemporary Aesthetics�] the aesthetic ideal of art has a meaning by presentive only social sympathy aesthetics; A German philosopher and aesthetician Alexander Gottlieb Baumgarten discusses the highest aesthetic value of art by social point of view [in the work �Aesthetics�], supports the main principle of his theory of art � life reaches its highest intensity in the socium as cooperation and collaboration and communication and in order to make it solid, it must deserve social sympathy � and unchangeably takes it into his theory of aesthetics. A famous French philosopher, thinker, writer, historian, one of the leaders of the French Enlightenment Francois Marie Arouet de Voltaire, French sociologist Charles de Montesquieu, German historian and theorist of art Johann Joachim Winckelmann, German philosopher, man of letters and critic Johann Gottfried Herder, English aesthetician and critic of art John Ruskin, German philosopher, founder of the philosophy of dialectical and historical materialism Karl Marx, French idealist philosopher, historian and theorist of art Hippolyte-Adolphe Taine by their original and completely social-aesthetic doctrine consider phenomenon of art by Organotropic formula that means they outline the peculiarities of the information function of art is pre-defined with some social conditions, especially geographic, geologic, climatic, biologic, social, political, cultural and historical factors. As it is seen from the paper, these are selected models of some searching aesthetic paradigms that have been identified to suggest that information content and status of the artistic creation works for the peculiar and special level of social condition and situation.
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