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Journal articles on the topic 'Organotin derivatives'

Author: Grafiati

Published: 18 May 2024

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1

Terraza, V. Fabricio, Darío C. Gerbino, and Julio C. Podestá. "Stereoselective Hydrostannation of Diacrylate and Dimethacrylate Esters of Galactaric Acid Derivatives: Cyclohydrostannation vs. Diaddition." Proceedings 9, no. 1 (November 14, 2018): 55. http://dx.doi.org/10.3390/ecsoc-22-05688.

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This paper reports a study on the free radical hydrostannation of ((4S,4′R,5R,5′S)-2,2,2′,2′-tetramethyl-[4,4′-bi(1,3-dioxolane)]-5,5′-diyl)bis(diphenyl methylene) diacrylate (1) and dimethacrylate (2) with triorganotin hydrides, R3SnH (R = Me, n-Bu, Ph). Preliminary investigations show that these reactions could lead to mixtures of products of cyclohydrostannation and/or mono- or diaddition according to the organotin hydrides employed and the reaction conditions used. The addition of Me3SnH to 1 afforded a mixture of three organotin compounds from which the pure new 13-membered macrodiolide 3 (48%) was obtained. The other two organotins could not be separated. The addition of n-Bu3SnH to diester 1 led to a mixture of two organotins, the one in major proportion (91%) being the product of diaddition 7. The minor product 6a (9%) could not be isolated pure. The hydrostannation of 1 with Ph3SnH led to one organotin: The product of diaddition 8. The hydrostannation of the dimethacrylate 2 with the organotin hydrides R3SnH (R = Me, n-Bu, Ph) under the same reaction conditions, led in the three cases to mixtures containing mainly diaddition products, and no cyclization products were detected. Some physical characteristics of the new compounds including selected values of 1H, 13C, and 119Sn NMRs are included.

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2

Kizlink, Juraj, and Vladimír Rattay. "Organotin derivatives of alkanedisulfonic acids." Collection of Czechoslovak Chemical Communications 52, no. 6 (1987): 1514–19. http://dx.doi.org/10.1135/cccc19871514.

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The preparation of dibutyltin and tributyltin alkanedisulfonates from alkyltin oxides and the corresponding alkanedisulfonic acids has been studied. The products, obtained in 56 – 74% yield, were tested as biocides against bacteria, yeasts, and moulds as well as fungicides against wood rot and their activity was compared with that of bis(tributyltin) oxide.

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3

Srivastava, Dileep K., and Lawrence Barton. "Organotin derivatives of hexaborane(10)." Organometallics 12, no. 7 (July 1993): 2864–68. http://dx.doi.org/10.1021/om00031a069.

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4

Hadi, Sutopo, Mona Dwi Fenska, Rama Aji Wijaya, Noviany Noviany, and Tati Suhartati. "Antimalarial Activity of Some Organotin(IV) Chlorobenzoate Compounds against Plasmodium falciparum." Mediterranean Journal of Chemistry 10, no. 3 (March 12, 2020): 213–19. http://dx.doi.org/10.13171/mjc0200312162sh.

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This paper reported the comparative study on antimalarial activity of some organotin(IV) derivatives with some chlorobenzoic acid derivatives used as the ligands. The compounds were synthesized by reacting the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, with chlorobenzoic acid. The antimalarial activity was performed against Plasmodium falciparum. The results showed that the IC50 of the compounds tested were about the same with the chloroquine (2 x 10-3 µg/mL) used as the positive control, but unlike chloroquine which has been known to have resistance as antimalarial, these organotin(IV) compounds prepared are not resistant to the Plasmodium. The result also showed that the derivative of triphenyltin(IV) has higher IC50respective to others.

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5

Salam, M. A., M. A. Affan, Ramkrishna Saha, Fasihuddin B. Ahmad, and Norrihan Sam. "Synthesis, Characterization andIn VitroAntibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone ()." Bioinorganic Chemistry and Applications 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/698491.

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Five new organotin(IV) complexes of 2-hydroxyacetophenone-2-methylphenylthiosemicarbazone [H2dampt, (1)] with formula [(dampt)] (where , (2); , (3); , (4);2, (5);2, (6)) have been synthesized by direct reaction of H2dampt (1) with organotin(IV) chloride(s) in absolute methanol. The ligand (1) and its organotin(IV) complexes (2–6) were characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR,1H,13C, and119Sn NMR spectral studies. H2dampt (1) is newly synthesized and has been structurally characterized by X-ray crystallography. Spectroscopic data suggested that H2dampt (1) is coordinated to the tin(IV) atom through the thiolate-S, azomethine-N, and phenoxide-O atoms; the coordination number of tin is five. Thein vitroantibacterial activity has been evaluated againstStaphylococcus aureus, Enterobacter aerogenes, Escherichia coli, andSalmonella typhi. The screening results have shown that the organotin(IV) complexes (2–6) have better antibacterial activities and have potential as drugs. Furthermore, it has been shown that diphenyltin(IV) derivative (6) exhibits significantly better activity than the other organotin(IV) derivatives (2–5).

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6

Ibadi, Falih, Emad Yousif, Mohammed Al-Mashhadani, Nany Hairunisa, and Muna Bufaroosh. "Recent Studies on Cancer Cell's Inhibition by Organotin (IV) Materials: An Overview." Al-Nahrain Journal of Science 26, no. 2 (June 1, 2023): 23–29. http://dx.doi.org/10.22401/anjs.26.2.04.

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organotin (IV) compounds have been the focus of recent studies for their potential use in the treatment of cancer. This review provides an overview of recent studies on the inhibition of cancer cells by organotin (IV) materials. The literature suggests that organotin (IV) compounds can selectively target cancer cells and induce apoptosis, making them promising candidates for anticancer drugs. The review covers various types of organotin (IV) compounds, including those containing alkyl, aryl, and amino groups, and their mechanisms of action against cancer cells. Additionally, the study explores the potential toxicity and biocompatibility of these compounds and their derivatives, as well as their potential use in combination therapy. Overall, the results of recent studies suggest that organotin (IV) compounds show great potential for the treatment of cancer. However, more research is needed to fully understand their mechanism of action and potential side effects. The review highlights the need for continued investigation of these compounds and their derivatives to develop effective and safe anticancer therapies

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7

Rusu, M., L. Muresan, A. R. Tomsab, D. Rusuc, and Gh Marcua. "New Organotin Derivatives of Keggin Polyoxomolybdates." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 30, no. 3 (March 2000): 499–511. http://dx.doi.org/10.1080/00945710009351777.

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8

Chauhan, H. P. S., S. Chourasia, Neeta Agrawal, and R. J. Rao. "Organotin(IV) Derivatives of Phthalanilic Acid." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 24, no. 2 (February 1994): 325–38. http://dx.doi.org/10.1080/00945719408000113.

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9

Costantino, Andrea R., Jörg M. Neudörfl, Romina A. Ocampo, Laura A. Svetaz, Susana A. Zacchino, Liliana C. Koll, and Sandra D. Mandolesi. "Synthesis, Characterization and Antifungal Assessment of Optically Active Bis-organotin Compounds Derived from (S)-BINOL Diesters." Open Chemistry Journal 6, no. 1 (May 31, 2019): 34–20. http://dx.doi.org/10.2174/1874842201906010034.

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Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities. Hence, it is important to study the synthesis of new organotin compounds with low toxicity that may be of pharmacological interest. Objectives: This study focuses on the synthesis of new bis-stannylated derivatives with C2 symmetry that could be tested as antifungal agents against two clinical important fungal species, Cryptococcus neoformans and Candida albicans. Methods: The radical addition of triorganotin hydrides (R3SnH) and diorganotin chlorohydrides (R2ClSnH) to bis-α,β-unsaturated diesters derived from (S)-BINOL led to the corresponding new bis-stannylated derivatives with C2 symmetry. Nine pure organotin compounds were synthesized with defined stereochemistry. Four of them were enantiomerically pure and four were diastereoisomeric mixtures. Results: All new organotin compounds were fully characterized, those with phenyl ligands bonded to tin were the most active compounds against both the strains (Cryptococcus neoformans and Candida albicans), with activity parameters of IC50 close to those of the reference drug (amphotericin B). Conclusion: Nine pure organotin compounds with C2 symmetry were synthesized with defined stereochemistry and their antifungal properties were tested against two clinical important fungi with IC values close to those of the reference drug. The structure-containing preferably two or three phenyl groups joined to the tin atom were highly active against both the strains compared with those possessing tri-n-butyl groups.

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10

Fatima Javed, Fatima Javed, Saqib Ali Saqib Ali, Khurram Shahzad Munawar Khurram Shahzad Munawar, Ali Haider Ali Haider, and N. A. Shah and Z. Rashid N A Shah and Z Rashid. "Synthesis, Structural Elucidation, and Therapeutic Screening of Organotin(IV) derivatives of oxo-ethyl carbonodithioate." Journal of the chemical society of pakistan 45, no. 4 (2023): 345. http://dx.doi.org/10.52568/001282/jcsp/45.04.2023.

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Exploring the therapeutic potential of organotin-based oxo-ethyl carbonodithioates, a series of organotin(IV) thiocarboamates (1-5) were synthesized with diverse alkyl and phenyl substituents. The chemical- composition, morphology, theoretical properties, and drug-DNA binding capabilities of the synthesized derivatives were performed by applying different characterization techniques like FT-IR, NMR (1H, 13C), AFM, DFT analysis, and UV-Vis spectroscopy respectively. The NMR data indicated six and four coordinated geometries, while the AFM results revealed smart surfaces concerning the grain size and root mean square (RMS) roughness, signifying catalytic and biocidal uses. The drug-DNA binding via intercalative mode of interaction with blue and red shifts was determined by using using UV spectroscopy. The in vitro biocidal capacity of selected complexes was evaluated against typical bacterial, fungal, cytotoxic, and leishmanial strains respectively. As a result of the surface and biocidal characterization, the synthesized complexes may be applied with greater potential in biomedical, pharmaceutical, infectious, catalysis, and cosmetics industries

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11

de Vos, Dick, Rudolph Willem, Marcel Gielen, Kyra E. van Wingerden, and Kees Nooter. "The Development of Novel Organotin Anti-Tumor Drugs: Structure and Activity." Metal-Based Drugs 5, no. 4 (January 1, 1998): 179–88. http://dx.doi.org/10.1155/mbd.1998.179.

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An overview of the development of anti-tumor organotin derivatives in selected classes of compounds is presented and discussed. High to very high in vitro activity has been found, sometimes equaling that of doxorubicin. Solubility in water is an important issue, dominating the in vivo testing of compounds with promising in vitro properties. The cytotoxicity of the compounds was increased by the presence of a bulky group, an active substituent or one or more polar substituents. Polar substituents may also improve the water solubility. Although organotin derivatives constitute a separate class of compounds, the comparison with cisplatin is inevitable. Among the observed toxicities, neurotoxicity, known from platinum cytostatics, and gastrointestinal toxicity, typical for many oncology drugs, have been detected. Further research to develop novel, useful organotin anti-tumor compounds should be carried out.

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12

Matela, Garima, and Robina Aman. "Organotin(IV) complexes of carboxylic acid derivatives." Open Chemistry 10, no. 1 (February 1, 2012): 1–15. http://dx.doi.org/10.2478/s11532-011-0107-6.

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AbstractA comprehensive review, >100 references, on organotin(IV) complexes of the carboxylic acid derivatives are presented with special reference to their methods of synthesis, spectroscopic and structural studies and their biological activities. The structures of these complexes are discussed on the basis of IR, multinuclear (1H-, 13C- and 119Sn-) NMR.

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13

Debbabi, Mongi, and Fatma Bannani Driss. "Organosilyl and organotin plenary Lindqvist polyoxometalate derivatives." Acta Crystallographica Section A Foundations of Crystallography 66, a1 (August 29, 2010): s175. http://dx.doi.org/10.1107/s0108767310096108.

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14

Tomşa, Adrian‐Raul, Aglaia Koutsodimou, Polycarpos Falaras, Marie‐Claude Bernard, and Mariana Rusu. "New Organotin Derivatives of Trilacunary Keggin Polyanions." Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 35, no. 8 (September 1, 2005): 651–59. http://dx.doi.org/10.1080/15533170500225599.

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15

Marchetti, Fabio, Claudio Pettinari, Augusto Cingolani, Riccardo Pettinari, Miriam Rossi, and Francesco Caruso. "Organotin(IV) derivatives of novel β-diketones." Journal of Organometallic Chemistry 645, no. 1-2 (February 2002): 134–45. http://dx.doi.org/10.1016/s0022-328x(01)01333-x.

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16

Mahon, M. F., K. C. Molloy, B. A. Omotowa, and M. A. Mesubi. "Organotin(IV) derivatives of acylpyrazol-5-ones." Journal of Organometallic Chemistry 511, no. 1-2 (April 1996): 227–37. http://dx.doi.org/10.1016/0022-328x(95)05906-6.

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17

Sabiha Khanam, Sabiha Khanam, Khadija Shahid Khadija Shahid, Muhammad Sirajuddin Muhammad Sirajuddin, and Saqib Ali and Hameed Ullah Saqib Ali and Hameed Ullah. "Synthesis, Spectral Characterization and Biological Evaluation of Organotin(IV) Complexes of Aniline Derivatives of Naturally Occurring Betulinic Acid." Journal of the chemical society of pakistan 41, no. 4 (2019): 725. http://dx.doi.org/10.52568/000785/jcsp/41.04.2019.

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Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (1H and 13C) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound L22SnMe2 was found with maximum antibacterial activity among the screened compounds. Compounds L12SnMe2 and L12SnPh2 were found with remarkable antifungal activity. Similarly L1, L12SnBu2, L2 and L22SnMe3 were remarked with good antioxidant activity.

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18

Shahid, Khadija, Saira Shahzadi, and Saqib Ali. "Synthesis, coordination and biological aspects of organotin(IV) derivatives of 4-[(2,4-dinitrophenyl)amino)]-4-oxo-2-butenoic acid and 2-{[(2,4-dinitrophenyl)amino]carbonyl}benzoic acid." Journal of the Serbian Chemical Society 74, no. 2 (2009): 141–54. http://dx.doi.org/10.2298/jsc0902141s.

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New series of organotin(IV) complexes of aniline derivatives, R2SnL2 and R3SnL [where R = Me, n-Bu, Ph, n-Oct] have been synthesized by the reaction of HL1 and HL2 with respective organotin halides or oxides. Experimental details for the preparation and characterization (including elemental analysis, IR and multinuclear NMR (1H-, 13C- and 119Sn-) spectra in CDCl3 and EI mass spectra of both series are provided. The binding sites of the ligands were identified by means of FTIR spectroscopic measurements. It was found that in all cases the organotin(IV) moiety reacts with the oxygen of COO- group to form new complexes. In the diorganotin complexes, the COO- group is coordinated to the organotin(IV) centres in a bidentate manner in the solid state. The 119Sn NMR data and the nJ(13C-119/117Sn) coupling constant support the tetrahedral coordination geometry of the organotin complexes in non-coordinating solvents. Biological activities (antibacterial, antifungal, cytotoxicity, antileishmanial and insecticidal) of these compounds are also reported.

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19

David, S., and S. Hanessian. "Regioselective manipulation of hydroxyl groups via organotin derivatives." Tetrahedron 41, no. 4 (January 1985): 643–63. http://dx.doi.org/10.1016/s0040-4020(01)96443-9.

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20

Jarosz, Slawomir, Elzbieta Kozlowska, Jerzy Sitkowski, and Lech Stefaniak. "119Sn NMR Spectra of Some Carbohydrate Organotin Derivatives." Journal of Carbohydrate Chemistry 16, no. 6 (August 1, 1997): 911–16. http://dx.doi.org/10.1080/07328309708006547.

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21

Sandhu, G. K., and N. Sharma. "Organotin(IV) derivatives of mercaptosuccinic and thiodiacetic acids." Applied Organometallic Chemistry 7, no. 1 (February 1993): 33–38. http://dx.doi.org/10.1002/aoc.590070103.

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22

Pichler, Johann, Philipp Müller, Ana Torvisco, and Frank Uhlig. "Novel diaminopropyl substituted organotin compounds." Canadian Journal of Chemistry 96, no. 4 (April 2018): 411–18. http://dx.doi.org/10.1139/cjc-2017-0713.

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A novel synthetic pathway involving the desilylation of a tin trimethylsilyl species (Ph2Sn(SiMe3)2) towards nonprotected di(3-aminopropyl)tin dichloride ((H2N(CH2)3)2SnCl2) is described. Di(3-aminopropyl)tin dichloride is then converted to the respective dicarboxylates species (H2N(CH2)3)2Sn(OCOR)2 containing carboxylic acids of different lengths (R = –CH3, –(CH2)10CH3). Depending on the nature of R, discrete packing effects are observed in the solid state of di(3-aminopropyl)tin dicarboxylate derivatives. All the synthesized substances were characterized by 1H, 13C, and 119Sn nuclear magnetic resonance data and also single crystal X-ray analysis. These compounds are a promising class of substances for biological, pharmaceutical, and technical applications.

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23

Engel, Annikka, Eike Dornsiepen, and Stefanie Dehnen. "Click reactions and intramolecular condensation reactions on azido-adamantyl-functionalized tin sulfide clusters." Inorganic Chemistry Frontiers 6, no. 8 (2019): 1973–76. http://dx.doi.org/10.1039/c9qi00424f.

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24

Da Silva Santos, Ane Francielly, and José Roberto Da Silveira Maia. "ANTIMICROBIAL EFFECT OF ORGANOTIN COMPOUNDS DERIVED FROM PHENOLIC SCHIFF BASES." Journal of Engineering and Exact Sciences 5, no. 5 (December 20, 2019): 0452–59. http://dx.doi.org/10.18540/jcecvl5iss5pp0452-0459.

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Several organotin(IV) derivatives of phenolic Schiff bases were prepared and investigated by spectroscopic methods. These compounds were bioassayed to evaluate their bacterial effect against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Salmonella typhimurium) microorganisms. Dimeric and monomeric compounds were characterized by infrared in solid state. Metallic centers having penta-, hexa-, and heptacoordination were identified by multinuclear NMR (1H, 13C and 119Sn) in solution. The di- and triorganotin(IV) derivatives were also investigated by conductimetric measurements in methanol, elemental analysis and melting point. The bioassay of these tin(IV) compounds showed that the best resulting activity was against S. aureus for the triphenyltin(IV) phenolic Schiff base derivatives, presenting MICs of 1.1 µM (0.6 mg mL-1) and 2.2 µM (1.3 mg mL-1).

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25

Awasarkar, P. A., Sarada Gopinathan, and C. Gopinathan. "Organoxytitanium and Organotin Derivatives of Dibasic Tetradentate Chelating Disulphides." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 15, no. 2 (March 1985): 133–47. http://dx.doi.org/10.1080/00945718508059374.

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26

Dixit, Purnima, and J. P. Tandon. "Organotin(IV) Derivatives of Substituted N-Aryl-O-hydroxyacetophenoneimine." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 18, no. 5 (January 1988): 439–47. http://dx.doi.org/10.1080/00945718808059496.

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27

Haiduc, Ionel, Cristian Silvestru, and Marcel Gielen. "Organotin Compounds: New Organometallic Derivatives Exhibiting Anti-Tumour Activity." Bulletin des Sociétés Chimiques Belges 92, no. 2 (September 1, 2010): 187–89. http://dx.doi.org/10.1002/bscb.19830920213.

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28

Matela, Garima, and Robina Aman. "ChemInform Abstract: Organotin(IV) Complexes of Carboxylic Acid Derivatives." ChemInform 43, no. 14 (March 8, 2012): no. http://dx.doi.org/10.1002/chin.201214219.

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29

Ruisi, Giuseppe, and Maria Teresa Lo Giudice. "Synthesis and spectroscopic characterization of organotin derivatives ofN-benzoylglycylglycine." Applied Organometallic Chemistry 5, no. 5 (September 1991): 385–91. http://dx.doi.org/10.1002/aoc.590050504.

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30

Gielen, Marcel, François Kayser, Olga B. Zhidkova, Vladimir Ts Kampel, Vladimir l. Bregadze, Dick de Vos, Monique Biesemans, Bernard Mahieu, and Rudolph Willem. "Synthesis, Characterization and In vitro Antitumour Activity of Novel Organotin Derivatives of 1,2- and 1,7-Dicarba-Closo-dodecaboranes." Metal-Based Drugs 2, no. 1 (January 1, 1995): 37–42. http://dx.doi.org/10.1155/mbd.1995.37.

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Several organotin derivatives of 1,2- and 1,7-dicarba-closo-dodecaboranes were synthesized and characterized by S119n Mössbauer, H1 , C13 and S119n NMR spectroscopy. Their antitumour activities in vitro against cancerous cell lines of human origin are reported.

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31

Chagas, Rafael César Russo, José Roberto da Silveira Maia, and Vany P. Ferraz. "Synthesis and characterisation of organotin(IV) derivatives of ambidentate ligands containing nitrogen and sulphur donor atoms." Main Group Metal Chemistry 34, no. 5-6 (December 1, 2011): 131–37. http://dx.doi.org/10.1515/mgmc-2012-0904.

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Abstract A series of organotin(IV) derivatives of bis(pyrimidin-2-ylthio)methane (ptm), 1,2-bis(pyrimidin-2-ylthio)ethane (pte) and 1,6-bis(pyrimidin-2-ylthio)hexane (pth) have been prepared in dichloromethane at room temperature. The 2:1 (M/L) molar ratio compounds have a general formula of [Sn2ClxPh8-xL] (x=2, 4, 6, 8; L=ptm, pte and pth). A 1:1 complex was also obtained by reacting SnClPh3 with pth. The organotin derivatives were characterised by multinuclear NMR (1H, 13C and 119Sn) and infrared spectroscopy, gel permeation chromatography (GPC), microanalysis and melting point. In the triphenyltin derivatives, 1, 5, 9 and 10 the tin atoms show a distorted trigonal-bipyramidal configuration where the ligand is monodentate towards the metal atom. In the compounds 2–4, 6–8 and 11–13, the tin atoms each exhibit a distorted octahedral configuration. Chelation is formed between the tin nucleus and the coordinating sulphur and nitrogen atoms. The correlation between the 1J(13C-119Sn) and C-Sn-C bond angle indicates formation of 5-coordinate compounds.

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32

Bhatra, Pooja, Jyoti Sharma, Ram Avatar Sharma, and Yashpal Singh. "Synthesis, characterization and antimicrobial activity of diorganotin(IV) derivatives of some bioactive bifunctional tridentate Schiff base ligands." Main Group Metal Chemistry 39, no. 1-2 (January 1, 2016): 1–8. http://dx.doi.org/10.1515/mgmc-2015-0022.

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33

Jambor, Roman, Libor Dostál, Aleš Růžička, Ivana Císařová, Jiří Brus, Michal Holčapek, and Jaroslav Holeček. "Organotin(IV) Derivatives of Some O,C,O-Chelating Ligands." Organometallics 21, no. 19 (September 2002): 3996–4004. http://dx.doi.org/10.1021/om020361i.

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34

Gupta, A. K., Sneh Sharma, H. P. S. Chauhan, and R. J. Rao. "Organotin(IV) Derivatives of 3-Substituted 2-Mercaptoquinazol-4-Ones." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 21, no. 3 (March 1991): 497–512. http://dx.doi.org/10.1080/15533179108018355.

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35

Shanker, R., and E. N. Sakuntala. "Tin(IV) and Organotin(IV) Derivatives of N-Benzalanthranilic Acid." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 15, no. 6 (June 1985): 779–88. http://dx.doi.org/10.1080/00945718508060595.

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36

Pettinari, C., F. Marchetti, A. Cingolani, A. Lorenzotti, E. Mundorff, M. Rossi, and F. Caruso. "Tin(IV) and organotin(IV) derivatives of novel β-diketones." Inorganica Chimica Acta 262, no. 1 (September 1997): 33–46. http://dx.doi.org/10.1016/s0020-1693(97)05500-x.

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37

Scoccia, Jimena, Darío César Gerbino, and Julio César Podestá. "Synthesis of organotin derivatives of optically active eleven-membered macrodiolides." Tetrahedron: Asymmetry 27, no. 7-8 (May 2016): 352–60. http://dx.doi.org/10.1016/j.tetasy.2016.02.014.

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38

Marchetti, Fabio, Claudio Pettinari, Augusto Cingolani, Lauro Brocanelli, Miriam Rossi, and Francesco Caruso. "Tin(IV) and organotin(IV) derivatives of novel β-diketones." Journal of Organometallic Chemistry 580, no. 2 (May 1999): 344–53. http://dx.doi.org/10.1016/s0022-328x(98)01173-5.

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39

Cruzado, Carmen, Manuel Bernabe, and Manuel Martin-Lomas. "Regioselective glycosylation of mono- and di-saccharides via organotin derivatives." Carbohydrate Research 203, no. 2 (August 1990): 296–301. http://dx.doi.org/10.1016/0008-6215(90)80028-2.

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40

Pettinari*, Claudio, Fabio Marchetti, Augusto Cingolani, Riccardo Pettinari, Andrei Drozdov, and Sergei Troyanov*. "Organotin(IV) derivatives containing bis(diphenylphosphine)- and bis(diphenylphosphineoxo)alkanes." Inorganica Chimica Acta 312, no. 1-2 (January 2001): 125–32. http://dx.doi.org/10.1016/s0020-1693(00)00358-3.

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Shiryaev, V. I., E. M. Stepina, S. N. Tandura, E. A. Kovaleva, A. A. Grachev, and S. I. Androsenko. "Synthesis and1H NMR study of some organotin derivatives of diethanolamines." Russian Chemical Bulletin 43, no. 4 (April 1994): 666–70. http://dx.doi.org/10.1007/bf00699845.

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42

Couce, M. D., V. Cherchi, G. Faraglia, U. Russo, L. Sindellari, G. Valle, and N. Zancan. "Synthesis and characterization of organotin complexes with 2-mercaptopyridine derivatives." Applied Organometallic Chemistry 10, no. 1 (February 1996): 35–45. http://dx.doi.org/10.1002/(sici)1099-0739(199602)10:1<35::aid-aoc475>3.0.co;2-d.

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43

JAROSZ, S., E. KOZLOWSKA, J. SITKOWSKI, and L. STEFANIAK. "ChemInform Abstract: 119Sn NMR Spectra of Some Carbohydrate Organotin Derivatives." ChemInform 28, no. 51 (August 2, 2010): no. http://dx.doi.org/10.1002/chin.199751230.

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Stefanizzi, Valeria, Antonella Minutolo, Elena Valletta, Martina Carlini, Franca M. Cordero, Anna Ranzenigo, Salvatore Pasquale Prete, et al. "Biological Evaluation of Triorganotin Derivatives as Potential Anticancer Agents." Molecules 28, no. 9 (May 2, 2023): 3856. http://dx.doi.org/10.3390/molecules28093856.

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Metal-derived platinum complexes are widely used to treat solid tumors. However, systemic toxicity and tumor resistance to these drugs encourage further research into similarly effective compounds. Among others, organotin compounds have been shown to inhibit cell growth and induce cell death and autophagy. Nevertheless, the impact of the ligand structure and mechanisms involved in the toxicity of organotin compounds have not been clarified. In the present study, the biological activities of commercially available bis(tributyltin) oxide and tributyltin chloride, in comparison to those of specially synthesized tributyltin trifluoroacetate (TBT-OCOCF3) and of cisplatin, were assessed using cells with different levels of tumorigenicity. The results show that tributyltins were more cytotoxic than cisplatin in all the tested cell lines. NMR revealed that this was not related to the interaction with DNA but to the inhibition of glucose uptake into the cells. Moreover, highly tumorigenic cells were less susceptible than nontumorigenic cells to the nonunique pattern of death induced by TBT-OCOCF3. Nevertheless, tumorigenic cells became sensitive when cotreated with wortmannin and TBT-OCOCF3, although no concomitant induction of autophagy by the compound was detected. Thus, TBT-OCOCF3 might be the prototype of a family of potential anticancer agents.

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Ioannidou, Anastasia, Agnieszka Czapik, Petros Gkizis, Muhamad Perviaz, Dimitrios Tzimopoulos, Maria Gdaniec, and Pericles D. Akrivos. "Aggregation of Hydrogen Bonded Dimeric Tri-Organotin Amino Substituted Pyrimidine-2-Thiolates." Australian Journal of Chemistry 66, no. 5 (2013): 600. http://dx.doi.org/10.1071/ch12537.

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The synthesis of six tri-organotin compounds with 4-amino and 4,6-diaminopyrimidine-2-thiolate is described. The compounds have the general formula R3Sn(thiolate) where R = Me, Bu, or Ph. The compounds are investigated by a variety of spectroscopic techniques both in solution and in the solid state. The environment around the tin centres proves to be tetrahedral with monodentate thiolate anions as is inferred from the infrared and NMR spectra. The coordination sphere is not affected even by the presence of DMSO as solvent. In the solid state, the crystal structure determination of the trimethyl and triphenyltin derivatives of the 4,6-diaminopyrimidine-2-thiolate ligand, reveal an association into centrosymmetric dimers through N–H⋯N hydrogen-bonding interactions leaving the organotin site practically unaffected. However, in addition to the classical hydrogen bonding, weaker N–H⋯RS and N–H⋯Rπ interactions are also present and play an important role in determining further aggregation of these dimers which gives rise to a three-dimensional polymeric structure in the case of the trimethyltin and a layer of dimers in the case of the triphenyltin derivative, respectively.

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Plasseraud, Laurent. "CO2 Derivatives of Molecular Tin Compounds. Part 1: Hemicarbonato and Carbonato Complexes." Inorganics 8, no. 5 (April 29, 2020): 31. http://dx.doi.org/10.3390/inorganics8050031.

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This review focuses on organotin compounds bearing hemicarbonate and carbonate ligands, and whose molecular structures have been previously resolved by single-crystal X-ray diffraction analysis. Most of them were isolated within the framework of studies devoted to the reactivity of tin precursors with carbon dioxide at atmospheric or elevated pressure. Alternatively, and essentially for the preparation of some carbonato derivatives, inorganic carbonate salts such as K2CO3, Cs2CO3, Na2CO3 and NaHCO3 were also used as coreagents. In terms of the number of X-ray structures, carbonate compounds are the most widely represented (to date, there are 23 depositions in the Cambridge Structural Database), while hemicarbonate derivatives are rarer; only three have so far been characterized in the solid-state, and exclusively for diorganotin complexes. For each compound, the synthesis conditions are first specified. Structural aspects involving, in particular, the modes of coordination of the hemicarbonato and carbonato moieties and the coordination geometry around tin are then described and illustrated (for most cases) by showing molecular representations. Moreover, when they were available in the original reports, some characteristic spectroscopic data are also given for comparison (in table form). Carbonato complexes are arbitrarily listed according to their decreasing number of hydrocarbon substituents linked to tin atoms, namely tri-, di-, and mono-organotins. Four additional examples, involving three CO2 derivatives of C,N-chelated stannoxanes and one of a trinuclear nickel cluster Sn-capped, are also included in the last part of the chapter.

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Nikolic, Danijela, Marija Gencic, Jelena Aksic, Niko Radulovic, Dusan Dimic, and Goran Kaludjerovic. "Diorganotin(IV) complexes with hydroxamic acids derivatives of some histone deacetylases inhibitors." Journal of the Serbian Chemical Society, no. 00 (2023): 64. http://dx.doi.org/10.2298/jsc230630064n.

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Organotin(IV) compounds show great potential as antitumor metallodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterized by high bioavailability and low toxicity. In this contribution, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4- phenylbutanamide (HL1) and N-hydroxy-2-propylpentanamide (HL2), have been prepared and characterized using FTIR, 1H, 13C, and 119Sn NMR spectroscopy. Particular emphasis was put on the binding characteristics of ligands. The structures were additionally analyzed by the Density functional theory at B3LYP-D3BJ/6-311++G(d,p)(H,C,N,O)/LanL2DZ(Sn) level. The theoretical IR and NMR spectra were compared to the spectroscopic data, and it was concluded that the predicted structures described well the experimental ones. The stability of different isomers of HL1 and HL2 was assessed by the Natural Bond Orbital analysis, and the importance of intramolecular hydrogen bond was outlined. The interactions between donor atoms and Sn were investigated and correlated with changes in chemical shift and wavenumbers of characteristic vibrations.

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Molloy, K. C., T. G. Purcell, D. Cunningham, P. McCardle, and T. Higgins. "Organotin biocides. X. Synthesis, structure and biocidal activity of organotin derivatives of 2-mercaptobenzothiazole, 2-mercaptobenzoxazole and 2-mercaptobenzimidazole." Applied Organometallic Chemistry 1, no. 2 (1987): 119–31. http://dx.doi.org/10.1002/aoc.590010204.

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Nath, Mala, Hitendra Singh, George Eng, and Xueqing Song. "Interaction of 5′-Guanosine Monophosphate with Organotin(IV) Moieties: Synthesis, Structural Characterization, and Anti-Inflammatory Activity." ISRN Organic Chemistry 2012 (December 9, 2012): 1–9. http://dx.doi.org/10.5402/2012/873035.

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Reaction(s) of 5′-guanosine monophosphate (5′GMP) with di- and triorganotin(IV) chloride(s) led to formation of organotin(IV) derivatives of general formulae, [R2Sn(5′-GMP)·H2O]n and [(R′3Sn)2(5′-GMP)·H2O]n, where R = Me, n-Bu, and Ph; R′ = Me, i-Pr, n-Bu, and Ph; (5′-GMP)2− = 5′-guanosine monophosphate. An attempt has been made to prove the structures of the resulting derivatives on the basis of FT-IR, multinuclear 1H, 13C, and 119Sn NMR and 119Sn Mössbauer spectroscopic studies. These investigations suggest that both di- and triorganotin(IV)-5′-guanosine monophosphates are polymeric in which (5′-GMP)2− is bonded through phosphate group resulting in a distorted trigonal bipyramidal geometry around tin. The ribose conformation in all of the derivatives is C3′-endo, except diphenyltin(IV) and tri-i-propyltin(IV) derivatives where it is C2′-endo. All of the studied derivatives exhibited mild-to-moderate anti-inflammatory activity (~15.64–20.63% inhibition) at 40 mg kg−1 dose and LD50 values > 400 mg kg−1 in albino rats.

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Hadi, Sutopo, Mita Rilyanti, and Suharso Suharso. "IN VITRO ACTIVITY AND COMPARATIVE STUDIES OF SOME ORGANOTIN(IV) BENZOATE DERIVATIVES AGAINST LEUKEMIA CANCER CELL, L-1210." Indonesian Journal of Chemistry 12, no. 2 (June 4, 2012): 172–77. http://dx.doi.org/10.22146/ijc.21359.

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A series of dibutyl-, diphenyl- and triphenyltin(IV) benzoate derivatives has been prepared. The products were obtained by reacting the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with benzoate acid and its derivative. The targeted compounds have been tested with anticancer activity against leukemia cancer cell, L-1210. The compounds synthesized were well characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies as well as based on the microanalytical data. The results showed that triphenyltin(IV) benzoate and its derivative prepared exhibit higher anticancer activity than those of dibutyltin(IV) and diphenyltin(IV) analogous.

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