Relevant bibliographies by topics / Organophosphorus compounds – Analysis

Academic literature on the topic 'Organophosphorus compounds – Analysis'

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Published: 4 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "Organophosphorus compounds – Analysis"

1

Vereshchagina, Yana A., Eleonora A. Ishmaeva, and Vladislav V. Zverev. "Theoretical conformational analysis of organophosphorus compounds." Russian Chemical Reviews 74, no. 4 (April 30, 2005): 297–315. http://dx.doi.org/10.1070/rc2005v074n04abeh000890.

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Kabachnik, M. I., and A. N. Nasmeyanov. "Analysis of CH-Acidity of Organophosphorus Compounds." Phosphorus, Sulfur, and Silicon and the Related Elements 77, no. 1-4 (April 1993): 97–100. http://dx.doi.org/10.1080/10426509308045628.

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Yoshifuji, Masaaki. "Sterically protected organophosphorus compounds of unusual structures." Pure and Applied Chemistry 89, no. 3 (March 1, 2017): 281–86. http://dx.doi.org/10.1515/pac-2016-1029.

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AbstractThe character of bis(2,4,6-tri-tert-butylphenyl)diphosphene is described experimentally and theoretically. The diphosphene is stabilized by steric protection and the structure can be characterized by spectroscopic as well as crystallographic analyses. Theoretical calculation on the diphosphene strongly suggests that the P=P bond is an isolated double bond and that the P–C bonds are single covalent bond. The reactivity has been investigated including photolysis, oxidation, sulfurization, selenation, transition-metal complex formation, and carbene addition. Plausible mechanistic scheme for the reaction of the diphosphene with 3,4,5,6-tetrachlorocyclohexa-3,5-diene-1,2-dione (or tetrachloro-o-benzoquinone) to a pentavalent spiro product is discussed based on the product analysis.
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4

Galkin, Vladimir I., Artem A. Cherkasov, and Rafael A. Cherkasov. "New Methods for Quantitative Analysis of Organophosphorus Compounds Reactivity." Phosphorus, Sulfur, and Silicon and the Related Elements 177, no. 8-9 (August 2002): 2207. http://dx.doi.org/10.1080/10426500213326.

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Vereshchagina, Yana A., Denis V. Chachkov, Eleonora A. Ishmaeva, Aisylu A. Gazizova, and Gulnaz R. Fattakhova. "Theoretical Conformational Analysis of Cyclic Organophosphorus and Organosilicon Compounds." Phosphorus, Sulfur, and Silicon and the Related Elements 186, no. 4 (March 31, 2011): 830–37. http://dx.doi.org/10.1080/10426507.2010.525767.

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6

KABACHNIK, M. I. "ChemInform Abstract: Analysis of CH-Acidity of Organophosphorus Compounds." ChemInform 24, no. 37 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199337073.

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7

Pokrovskaya, Elena. "Fire-protection of wooden structures by modification in a thin surface layer." MATEC Web of Conferences 251 (2018): 02028. http://dx.doi.org/10.1051/matecconf/201825102028.

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The mechanism of fire protection of wood by the modification of a thin surface layer with organophosphorus compounds has been studied. The properties of the modified thin surface layer were studied by X-ray spectral analysis, IR spectroscopy and differential thermal analysis. Promising wood modifiers have been identified and the conditions for effective fire protection of wooden structures with organophosphorus compounds in a thin surface layer have been determined.
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Suye, Shin-ichiro, Keiji Tsuchiya, Hirokazu Makishima, Ashok Mulchandani, Kouichi Kuroda, Yasufumi Enami, and Mitsuyoshi Ueda. "Single cell analysis for organophosphorus compounds sensing using organophosphorus hydrolase and EGFP displayed arming yeast." Journal of Bioscience and Bioengineering 108 (November 2009): S148—S149. http://dx.doi.org/10.1016/j.jbiosc.2009.08.398.

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9

Paukku, Y., and G. Hill. "Quantum topological molecular descriptors in QSAR analysis of organophosphorus compounds." International Journal of Quantum Chemistry 112, no. 5 (May 16, 2011): 1343–52. http://dx.doi.org/10.1002/qua.22995.

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Hu, Jiaxin, Cheng Qian, Yinchenxi Zhang, Yonghui Tian, and Yixiang Duan. "Sol–gel fabrication and performance evaluation of graphene-based hydrophobic solid-phase microextraction fibers for multi-residue analysis of pesticides in water samples." Analytical Methods 12, no. 31 (2020): 3954–63. http://dx.doi.org/10.1039/d0ay01153c.

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Dissertations / Theses on the topic "Organophosphorus compounds – Analysis"

1

Donoghue, Neil Chemistry Faculty of Science UNSW. "Aspects of reductive methods in organophosphorus chemistry." Awarded by:University of New South Wales. School of Chemistry, 1998. http://handle.unsw.edu.au/1959.4/22405.

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This study is concerned with the reductive cleavage of tetracoordinated organophos-phorus compounds (either quaternary phosphonium salts R4P+ X??? or tertiary phosphine oxides R3P=O) with either the naphthalene radical (naphthalenide) anion or lithium aluminium hy-dride in THF solution at room temperature (RT). Part 1 examines the reaction of lithium naphthalenide with both phosphonium salts and phosphine oxides. The reaction was dem-onstrated to cleave phenyl groups from both bis-salts and bis-oxides in the presence of 1,2-ethylene bridges; based upon this, parallel syntheses of either 1,4-diphosphabicyclo[2.2.2]oc-tane or its P,P'-dioxide were attempted by using the commercially available ethane-1,2-bis-(diphenylphosphine) as the starting material in each case. Examination of the products ofreductive cleavage of the series of benzylphenylphosphonium bromide [PhnP(CH2Ph)4-n]+ Br???(where n = 0 to 3) with lithium naphthalenide leads to the proposal of a mechanism. Part 2 describes hydridic reductions of both quaternary phosphonium salts and ter-tiary phosphine oxides. Examination of the lithium aluminium hydride reduction of qua-ternary phosphonium salts using 31P-NMR has confirmed tetraorganophosphoranes (R4PH; R = Ph, alkyl) as intermediates in the reaction; in addition, two previously unknown classes of compounds, the triorganophosphoranes R3PH2 and the tetraorganophosphoranates R4PH2???, were also found to be intermediates. The behaviour of bis-phosphonium salts where the phosphonium centres are separated by either 1,2-ethylene or 1,3-propylene bridges are also examined. Formation of a monocation exhibiting a bridging hydride occurs when the cyclic bis-phosphonium salt 1,1,5,5-tetraphenyl-1,5-diphosphocanium dibromide is reacted with li-thium aluminium hydride. Mechanisms are proposed which are consistent with the observed experimental results.
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2

Chen, Qidan, and 陈奇丹. "Hyphenation of quantum dots-mediated photodetection and continuous microevaporation with capillary electrophoresis for determination ofpesticide residues and acrylamide in vegetables and food." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45194191.

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3

O'Hair, Richard Alfred John. "Studies in gas phase ion chemistry : a thesis presented for the degree of Doctor of Science in the Faculty of Science of the University of Adelaide /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09SD/09sdo362.pdf.

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4

Parrish, Douglas K. "Application of solid phase microextraction with gas chromatography-mass spectrometry as a rapid, reliable, and safe method for field sampling and analysis of chemical warfare agent precursors /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Parrish2005.pdf.

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5

Biapo, Fankep Dorianne Urelle. "Nanostructuration et fonctionnalisation de microleviers pour la détection d’agents organophosphorés." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAF044.

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La détection d’agents organophosphorés (OPs) demeure l’un des problèmes majeurs à résoudre pour prévenir la menace chimique. A cet effet, la recherche de capteurs sensibles, sélectifs, portables reste d’un grand intérêt. Dans ce projet, notre intérêt s’est porté vers des microleviers dont le principe repose sur la modification de leur fréquence de résonance due à une adsorption de molécules à leur surface. Un concept associant la nanostructuration et la fonctionnalisation a été étudié pour améliorer les performances des leviers. Ainsi, la surface des microleviers a été nanostructurée par voie solvothermale avec des nanobâtonnets de TiO2 pour accroitre leur capacité d’adsorption et leur sensibilité. Ces leviers nanostructurés ont ensuite été fonctionnalisés par des molécules (alcool, oxime) susceptibles de se lier spécifiquement aux OPs pour améliorer leur sélectivité. La nanostructuration et la fonctionnalisation ont été préalablement optimisées sur des surfaces modèles avant d’être transférées sur des leviers. Une étude paramétrique a été menée pour évaluer l’impact des conditions de synthèse sur la morphologie des structures. La capacité de greffage des nanostructures a été évaluée et les meilleures structures ont été reproduites sur les leviers pour les tests de détection d’un simulant d’OPs. Des études plus spécifiques ont également été menées pour comprendre les mécanismes d’interactions entre les OPs et le TiO2
The detection of organophosphorous compounds remains one of the major issues to be addressed in order to prevent chemical threats. For that purpose, the need of sensitive and selective sensor is of great importance. In this study, we decided to use microcantilevers whose principle is based on the modification of their resonance frequency due to molecule adsorption onto their surface. The idea of this project is to combine the nanostructuration and functionalization to improve cantilevers performances. Thus, the microcantilevers surface was nanostructured using solvothermal method with TiO2 nanorods to increase their adsorption capacity and then, cantilevers sensibility. Those nanostructured cantilevers was then functionalized by molecules able to specifically bind OPs molecules to improve sensors selectivity. The nanostructuration and functionalization were first optimized on silicon substrates before being transferred onto cantilevers. A parametric study was performed to evaluate the impact of synthesis conditions on the nanostructures morphology. The molecules loading on TiO2 nanorods was evaluated and the best nanostructure was reproduced on cantilevers to carry out detection tests of an OPs simulant. Specific investigation was also performed to understand the interaction mechanism between OPs and TiO2
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6

Eguzozie, Kennedy Uchenna. "Absorption spectroscopy and surface enhanced vibrational techniques for monitoring dephosphorylation and phosphorylation reactions in model compounds." Thesis, 2012. http://hdl.handle.net/10500/11960.

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Mechanistic aspects of phosphorylation, dephosphorylation, pyrophosphorylation and depyrophosphorylation reactions that mimic phosphorylases, dephosphorylases, pyrophosphorylases and depyrophosphorylases have been studied in the biologically important middle pH region. The different systems monitored are; (a) the reactions between [{CoN4(OH)(OH2)}]2+ and [HPO4]- for 1:1, 2:1 and 3:1 [{CoN4(OH)(OH2)}]2+ to [HPO4]2- ratios. (b) the reactions between [{CoN4PO4] and [O2NC6H4O]- (abbreviated as NP-) for 1:1, 2:1 and 3:1 [{CoN4PO4] to [O2NC6H4O]- ratios. (c) the reactions between [{CoN4(OH)(OH2)}]2+ and [O2NC6H4PO4]2- (abbreviated as NPP2-) for 1:1, 2:1 and 3:1 [{CoN4(OH)(OH2)}]2+ to [O2NC6H4PO4]2- ratios. (d) the reactions between [{CoN4(OH)(OH2)}]2+ and [H2P2O7]2- for 1:1, 2:1 and 3:1 [{CoN4(OH)(OH2)}]2+ to [H2P2O7]2- ratios. (e) the reactions between [{CoN4P2O7}]- and [O2NC6H4O]- for 1:1, 2:1 and 3:1 [{CoN4P2O7}]- to [O2NC6H4O]- ratios. Significant phosphorylation was noted for systems containing 1:1 molar ratio [{CoN4PO4] and [O2NC6H4O]-. Enhanced phosphorylation was depicted for system containing 1:1 molar ratio of [{CoN4(OH)}2PO4]+ and [O2NC6H4O]-. Pyrophosphorylation was noted for reactions of 1:1 molar ratio of [{CoN4P2O7}]- and [O2NC6H4O]-. The rate of pyrophosphorylation was substantially reduced for systems that were 2:1 in molar ratio of [{CoN4P2O7}]- and [O2NC6H4O]-. No appreciable pyrophosphorylation was noted for systems, which has a 3:1 molar ratio of [{CoN4P2O7}]- and [O2NC6H4O]-. Specific mechanistic features and the possible roles metal ions play in phosphorylase, dephosphorylase and pyrophosphorylase are highlighted from results of UV-Visible spectroscopy, 31P {1H} NMR spectroscopy and Surface Enhanced Raman Scattering (SERS) studies
Chemistry
D.Phil. (Chemistry)
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Books on the topic "Organophosphorus compounds – Analysis"

1

Kroening, Karolin K. Analysis of Chemical Warfare Degradation Products. Chichester, West Sussex, United Kingdom: Wiley, 2011.

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2

Makarov, M. I. Fosfor organicheskogo veshchestva pochv. Moskva: GEOS, 2009.

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3

Jha, Virendra K. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory: Determination of organophosphate pesticides in bottom sediment by gas chromatography with flame photometric detection. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 2003.

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Jha, Virendra K. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory: Determination of organophosphate pesticides in bottom sediment by gas chromatography with flame photometric detection. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 2003.

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Jha, Virendra K. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory: Determination of organophosphate pesticides in whole water by continuous liquid-liquid extraction and capillary-column gas chromatography with flame photometric detection. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 2003.

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Jha, Virendra K. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory: Determination of organophosphate pesticides in whole water by continuous liquid-liquid extraction and capillary-column gas chromatography with flame photometric detection. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 2003.

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7

E, Merian, ed. Chemistry and fate of organophosphorus compounds. New York: Gordon and Breach Science Publishers, 1987.

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Great Britain. Standing Committee of Analysts., ed. Organophosphorus pesticides in sewage sludge ; Organophosphorus pesticides in river and drinking water: An addition, 1985. London: H.M.S.O., 1986.

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S, Wydoski Duane, and Geological Survey (U.S.), eds. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory: Determination of organophosphate pesticides in filtered water by gas chromatography with flame photometric detection. Denver, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 2002.

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Book chapters on the topic "Organophosphorus compounds – Analysis"

1

Efremenko, Elena, and Il'ya Lyagin. "Enzymatic detection of organophosphorus compounds." In ORGANOPHOSPHORUS NEUROTOXINS, 183–204. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/31_183-204.

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Organophosphorus compounds (OPC) are capable of affecting a wide variety of biological targets, including enzymes. At the same time, there is a large group of enzymes that modify these OPC, mainly by hydrolysis. In total, both those and other enzymes can be involved in determining the content of various OPC. This chapter presents the latest scientific developments in the field of enzyme biosensors for the analysis of OPC in a wide variety of environmental objects. For these purposes, soluble and immobilized forms of enzymes, their various combinations, as well as crude enzymes as a components of microorganisms’ cells can be used. Modern methods make it possible to reach the detection limits of OPC of 10–12 g/L with optical or electrochemical registration of the signal, which opens up enormous prospects for the use of such biosensors in practice. Special examples of commercially available enzyme biosensors for OPC determining are provided.
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2

Eremin, Sergey. "Immunochemical methods for detection of organophosphorus compounds." In ORGANOPHOSPHORUS NEUROTOXINS, 219–30. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/33_219-230.

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Organophosphorus compounds (OP) are found in environmental objects and food products. Due to their high toxicity and inhibition of cholinesterase activity, it is necessary to control residual amounts of OP. The most common methods for determining OP are gas and liquid chromatography with various detection methods. However, chromatographic analysis is lengthy, requires complex sample preparation and expensive equipment, which limits its use for screening a large number of samples and continuous monitoring of the content of OP. To detect the OP, it is necessary to use High Throughput Screening methods, using simple, fast and inexpensive analysis methods. Currently, immunochemical methods are increasingly used to determine OP. These methods are based on the recognition of the analyte (antigen) by specific receptors (antibodies) with the formation of the antigen-antibody complex and the measurement of the analytical signal generated by the immunochemical test system in response to complex formation, which leads to high sensitivity and specificity of the analysis.
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Efremenko, Elena, Il'ya Lyagin, Valentin Gorelenkov, Vasiliy Zavialov, Nataliya Zavialova, and George Frolov. "Self-defending (self-degasing) materials for protection against organophosphorus compounds." In ORGANOPHOSPHORUS NEUROTOXINS, 321–39. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/51_321-339.

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The paper presents an analysis of theoretical and experimental studies of national and foreign scientists developing “self-cleaning” (self-degassing) materials for personal protection, providing increased survival of people under the influence of warfare organophosphorus compounds. The use of enzymes as components of modern protective materials obtained using nano- and chemical-biological biocatalytic technologies is summarized.
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4

Campanella, L., and M. Tomassetti. "Enzyme Inhibition Sensor for Organophosphorus Pesticides Analysis." In Uses of Immobilized Biological Compounds, 489–99. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1932-0_47.

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Gorbunov, Konstantin, and Denis Gudkov. "Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind." In ORGANOPHOSPHORUS NEUROTOXINS, 44–66. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/13_044-066.

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Organophosphorus compounds (OPC) have been known for about 90 years: drugs and pesticides, poisons causing paralysis, convulsions and death in case of acute poisoning and leading to cancer, malformations and cognitive impairment in case of chronic exposure by doses that do not cause acute intoxication. Despite the existing measures, deaths due to OPC poisoning are recorded annually. The problem of children development after any poisoning even with small doses of these substances is especially urgent. Modern technologies provide new perspectives for the analysis of chronic intoxication by OPC, prognosis of acute poisoning severity and long-term health consequences. Research of miRNA and metabolomics came to the first place among the scientific approaches to the study of the body’s response to various external stimuli, including OPC poisoning. New methods are being developed to prevent the effects of poisoning based on stabilized bacterial enzymes, as well as modified miRNA.
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6

Varfolomeev, Sergey, Bella Grigorenko, Sofya Lushchekina, Patrick Masson, Galina Mahaeva, Dana Novichkova, and Alexander Nemuchin. "Study and modeling of mechanisms of cholinesterasis reactions in order to improve their catalytic properties in the neutralization reactions of organophosphorus compounds." In ORGANOPHOSPHORUS NEUROTOXINS, 140–80. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/23_140-180.

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“Biocleaners” or “bioscavengers” are biological objects (enzymes, catalytic antibodies) that are capable of binding and/or hydrolyzing organophosphorus compounds (OPC). Their use seems to be the most effective alternative to traditional antidotes to neutralize or detoxify OPC. The introduction of bioscavengers allows neutralizing toxicant molecules in the bloodstream before they reach their biological targets, thereby providing protection against poisoning. Bioscavengers of the first-generation neutralized OPC molecules by stoichiometrically binding to them. The safety and efficacy of human butyrylcholinesterase (BChE) for protecting against OPC poisoning has been shown. However, the stoichiometric neutralization of OPC requires the introduction of a huge amount of expensive biopharmaceuticals. Catalytic bioscavengers that hydrolytically neutralize OPC were introduced at a much lower dose to achieve the same degree of effectiveness. The most effective catalytic bioscavengers are enzymes. The most promising enzymes are artificial mammalian paraoxonase mutants and bacterial phosphotriesterases. However, studies of other enzymes, such as prolidases, oxidases, artificial mutants of cholinesterases and carboxyl esterases and catalytic antibodies are actively ongoing. Since OPC are pseudosubstrates of cholinesterases (ChEs), a detailed description of the mechanisms of inhibition, dealkylation, and spontaneous reactivation of phosphorylated ChEs is critical for the development of ChEs mutants with a high rate of hydrolysis of OPC. The review presents an analysis of different views on the mechanisms of interaction of ChEs with OPC, discusses the possible directions of creating effective catalytic biological traps based on BChE and changes in their mechanism of action as compared to the native enzyme. A separate section is devoted to the effect of mutations, both polymorphic and artificial, on the stability of the protein molecule of BChE.
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Efremenko, Elena, and Il'ya Lyagin. "Enzymatic detection of organophosphorous compounds." In Organophosphorous Neurotoxins, 177–98. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/chapter_5e4132b6069765.69067744.

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Organophosphorus compounds (OPC) are capable of affecting a wide variety of biological targets, including enzymes. At the same time, there is a large group of enzymes that modify these OPC, mainly by hydrolysis. In total, both those and other enzymes can be involved in determining the content of various OPC. This chapter presents the latest scientific developments in the field of enzyme biosensors for the analysis of OPC in a wide variety of environmental objects. For these purposes, soluble and immobilized forms of enzymes, their various combinations, as well as crude enzymes as a components of microorganisms’ cells can be used. Modern methods make it possible to reach the detection limits of OPC of 10–12 g/L with optical or electrochemical registration of the signal, which opens up enormous prospects for the use of such biosensors in practice. Special examples of commercially available enzyme biosensors for OPC determining are provided
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8

Gorbunov, Konstantin, and Denis Gudkov. "Organophosphorus compounds: a hidden threat to the health and wellbeing of mankind." In Organophosphorous Neurotoxins, 38–60. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/chapter_5e4132b5ef4563.55205914.

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Organophosphorus compounds (OPC) have been known for about 90 years: drugs and pesticides, poisons causing paralysis, convulsions and death in case of acute poisoning and leading to cancer, malformations and cognitive impairment in case of chronic exposure by doses that do not cause acute intoxication. Despite the existing measures, deaths due to OPC poisoning are recorded annually. The problem of children development after any poisoning even with small doses of these substances is especially urgent. Modern technologies provide new perspectives for the analysis of chronic intoxication by OPC, prognosis of acute poisoning severity and long-term health consequences. Research of miRNA and metabolomics came to the first place among the scientific approaches to the study of the body’s response to various external stimuli, including OPC poisoning. New methods are being developed to prevent the effects of poisoning based on stabilized bacterial enzymes, as well as modified miRNA.
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9

Varfolomeev, Sergey, Bella Grigorenko, Sofya Lushchekina, Patrick Masson, Galina Mahaeva, Dana Novichkova, and Alexander Nemuchin. "Study and modeling of mechanisms of cholinesterasis reactions in order to improve their catalytic properties in the neutralization reactions of organophosphorous compounds." In Organophosphorous Neurotoxins, 134–74. ru: Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/chapter_5e4132b603bfc4.70818543.

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“Biocleaners” or “bioscavengers” are biological objects (enzymes, catalytic antibodies) that are capable of binding and/or hydrolyzing organophosphorus compounds (OPC). Their use seems to be the most effective alternative to traditional antidotes to neutralize or detoxify OPC. The introduction of bioscavengers allows neutralizing toxicant molecules in the bloodstream before they reach their biological targets, thereby providing protection against poisoning. Bioscavengers of the first-generation neutralized OPC molecules by stoichiometrically binding to them. The safety and efficacy of human butyrylcholinesterase (BChE) for protecting against OPC poisoning has been shown. However, the stoichiometric neutralization of OPC requires the introduction of a huge amount of expensive biopharmaceuticals. Catalytic bioscavengers that hydrolytically neutralize OPC were introduced at a much lower dose to achieve the same degree of effectiveness. The most effective catalytic bioscavengers are enzymes. The most promising enzymes are artificial mammalian paraoxonase mutants and bacterial phosphotriesterases. However, studies of other enzymes, such as prolidases, oxidases, artificial mutants of cholinesterases and carboxyl esterases and catalytic antibodies are actively ongoing. Since OPC are pseudosubstrates of cholinesterases (ChEs), a detailed description of the mechanisms of inhibition, dealkylation, and spontaneous reactivation of phosphorylated ChEs is critical for the development of ChEs mutants with a high rate of hydrolysis of OPC. The review presents an analysis of different views on the mechanisms of interaction of ChEs with OPC, discusses the possible directions of creating effective catalytic biological traps based on BChE and changes in their mechanism of action as compared to the native enzyme. A separate section is devoted to the effect of mutations, both polymorphic and artificial, on the stability of the protein molecule of BChE.
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10

Dagnac, Thierry, and Roger Jeannot. "Organophosphorus Compounds in Water, Soils, Waste, and Air." In Chromatographic Analysis of the Environment, Third Edition, 841–88. CRC Press, 2005. http://dx.doi.org/10.1201/9781420027983.ch23.

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