Dissertations / Theses on the topic 'Organ transplantation'
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Desai, Rajeev Ramarao. "Organ transplantation related cancer." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6907/.
Full textPummer-Verté, Lila. "Organ donation and transplantation /." Online version of thesis, 1995. http://hdl.handle.net/1850/12252.
Full textRuers, Theodoor Jacques Marie. "Selective immunosuppression in organ transplantation." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5415.
Full textHardstaff, Ruth. "Compliance post solid organ transplantation." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493240.
Full textShubane, Nancy. "Black critical care nurses' perceptions of organ donation and organ transplantation." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-10262009-185326/.
Full textPuig-Pey, Comas Isabel. "Phenotypic and Transcriptional Biomarkers In Organ Transplantation." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/927.
Full text1. Characterization of gamma-delta-T cell subsets in organ transplantation
gamma-delta-T cells are innate-type lymphocytes that preferentially act as regulators of local effector immune responses. Recent reports found an altered distribution of the two main subpopulations of blood gamma-delta-T cells (V-delta-1 and V-delta-2) in operationally tolerant liver transplant recipients. Based on this, gamma-delta-T cells subset quantification was proposed as a biomarker of immunologic risk in liver transplantation. The specific characteristics of gamma-delta-T cell subsets in transplantation remain however unknown. We have investigated here the phenotype, repertoire and functional properties of gamma-delta-T cell subsets in a large population of allograft recipients. Our results indicate that alterations in the gamma-delta-T cell compartment are not restricted to tolerant liver recipients. In fact, most immunosuppressed liver and kidney recipients also display an enlarged peripheral blood gamma-delta-T cell pool mainly resulting from an expansion of V-delta-1 T cells exhibiting an oligoclonal repertoire and different phenotypic and cytokine production traits than V-delta-2 T cells. We propose that persistent viral infections are likely to contribute to these alterations. Our data provide novel insight in the biology of gamma-delta-T cells and a rationale for exploring these lymphocytes in more depth into the pathogenesis of viral infections in transplantation.
2. Comparative Transcriptional and Phenotypic Peripheral Blood Analysis of Kidney Recipients under Cyclosporin A or Sirolimus Monotherapy
Due to its low level of nephrotoxicity and capacity to harness tolerogenic pathways, sirolimus (SRL) has been proposed as an alternative to calcineurin inhibitors in organ transplantation. However, the exact mechanisms underlying its unique immunosuppressive profile in humans are still not well understood. In the current study, we aimed to depict the in vivo effects of SRL in comparison with cyclosporine A (CSA) by employing gene expression profiling and multiparameter flow cytometry on blood cells collected from stable kidney recipients under monotherapy with either SRL or CSA. In addition, the overall effect of these drugs on immunoregulatory pathways was assessed by measuring a transcriptional signature characteristic of operationally tolerant kidney recipients. Samples from SRL recipients displayed an increased frequency of effector memory T cells and were enriched in NFkB-related pro-inflammatory expression pathways and in monocyte and NK cell lineage-specific transcripts. Furthermore neither SRL nor CSA induced a gene expression profile comparable with that of tolerant kidney recipients. In conclusion, we show here that the overall pattern of SRL effect in vivo is dominated by innate immune cells and NFkB-related pro-inflammatory events. These data provide novel insights on the complex effects of SLR on the immune system in clinical transplantation.
"Biomarcadors fenotípics i transcripcionals
en el transplantament d'òrgans"
TEXT:
1. Estudi de les cèl·lules T gamma-delta A l'al·lotransplantament d'òrgans
1.1 Objectius
- Investigació detallada de la freqüència, fenotip, repertori del TCR i característiques funcionals de les poblacions Vdelta1 i Vdelta2 en sang perifèrica en trasplantats.
- Determinar si l'òrgan trasplantat, la teràpia immunosupressora i la presència d'infeccions víriques influeixen en la distribució i propietats de les subpoblacions gamma-delta.
- Avaluar el valor clínic de la quantificació de les cèl·lules T gamma-delta com a biomarcador diagnòstic de trasplantats tolerants operacionals de fetge.
1.2 Resultats
Es van quantificar les poblacions de gamma-delta totals, Vdelta1, Vdelta2 i ràtio Vdelta1/Vdelta2 en 201 trasplantats de fetge estables (STA-Liver), 29 tolerants operacionals trasplantats de fetge (TOL), 50 trasplantats estables de ronyó (STA-Kidney), 50 malalts amb insuficiència hepàtica terminal (ESLD) i 34 controls sans (CONT). Vem observar un increment de la població gamma-delta total en tots els grups de pacients trasplantats respecte CONT, que venia determinat per un increment de la població Vdelta1, més significatiu en el cas dels TOL, i una disminució de Vdelta2.
Vem demostrar que les freqüències del fenotip són estables en el temps determinant el percentatge d'expressió de Vdelta1 i Vdelta2 dues vegades amb 14 mesos de diferència.
El fenotipatge realitzat a les poblacions Vdelta1 i Vdelta2 en 19 pacients STA-Liver, va mostrar que aquestes subpoblacions expressen marcadors cel·lulars de superfície, intracel·lulars i funcionals diferents entre si. Aquests marcadors, però no serviren per diferenciar una cohort de 9 TOL i 10 STA-Liver. Vàrem assajar la utilitat diagnòstica dels percentatges de Vdelta1 i Vdelta2 per diferenciar TOL i STA-Liver utilitzant una corba ROC. Els resultats no varen ser positius.
Vam correlacionar la freqüència d'infeccions víriques persistents amb la distribució de les subpoblacions T gamma-delta. CMV i HCV, provocaven una alteració independent entre si i significativa en el ràtio Vdelta1/Vdelta2. Vam estudiar, finalment la diversitat clonal del TCR de la població Vdelta1. Es va clonar i seqüenciar la CDR3 del TCR Vdelta1. Els TOL mostren una tendència, estadísticament significativa, cap a un repertori restringit del TCR Vdelta1. Vam determinar si aquestes seqüències de nucleòtids es traduïen en grups d'aminoàcids compartits en la CDR3 de V1 però el resultat fou negatiu.
1.3. Conclusions
- La majoria dels receptors d'un transplantament mostren un increment en sang perifèrica de la població de cèl·lules T gamma-delta.
- La distribució alterada en sang perifèrica de les subpoblacions T gamma-delta és estable en un període de temps establert.
- Les infeccions per CMV i HCV afecten la freqüència relativa de les subpoblacions gamma-delta i el ràtio Vdelta1/Vdelta2 en sang perifèrica en pacients trasplantats de fetge.
- Les cèl·lules T Vdelta1 mostren ser fenotípica i funcionalment diferents de les Vdelta2.
- El repertori de CDR3 del receptor de les cèl·lules T Vdelta1 està restringit en receptors de fetge tolerants operacionals.
- Ni la quantificació de subpoblacions T gamma-delta ni la seva caracterització fenotípica permeten discriminar de forma acurada entre TOL i els STA-Liver.
2. Anàlisi fenotípic i transcripcional de receptors d'un transplantament de ronyó en monoteràpia amb CsA o sirolimus
2.1 Objectius
- Establir els efectes in vivo de sirolimus i CsA en sang perifèrica utilitzant tècniques de cribatge d'alt rendiment, per generar un perfil fenotípic i transcripcional de les dues cohorts de pacients.
- Determinar l'expressió d'una sèrie de biomarcadors associats a tolerància en aquests pacients, a partir d'un perfil generat anteriorment en tolerants operacionals renals.
2.2 Resultats
Es varen determinar les diferències fenotípiques de les dues cohorts i vàrem determinar que els pacients tractats amb sirolimus (SRL) mostraven un increment en la població CD4 de memòria efectora (CD45RA-CCR7-) respecte els pacients CSA. El grup SRL també presentava un increment en l'expressió de cèl·lules Tregs (CD4+CD25highFoxp3+) comparat amb CSA.
Vam fer estudis de microarray d'Affymetrix a partir de sang perifèrica. Vam fer un anàlisi comparatiu de dades utilitzant SAM (FDR<5%). El resultat d'aquest anàlisi ens va permetre identificar un total de 486 gens upregulated i 586 gens downregulated en el grup SRL respecte CSA.
Per interpretar el conjunt de gens diferentment expressats vam utilitzar el mètode GSEA, que ens va permetre identificar un enriquiment en el grup SRL de vies de senyalització relacionades amb mTOR i vies pro-inflamatòries comparat tant amb CSA com amb el grup d'individus sans.
Utilitzant Haematolgy Expression Atlas vam identificar una representació significativa de trànscrits específics per monòcits i cèl·lules NK en SRL, i per cèl·lules T CD4+ i limfòcits B en el grup CSA.
El software IPA-Tox va identificar NFκB com la via de senyalització més representativa respecte els gens estudiats.
Per últim vàrem determinar la prevalença de biomarcadors relacionats amb tolerància operacional en pacients trasplantats de ronyót. Dels 37 pacients estudiats només 1 SRL i 3 CSA varen ser predits com a potencialment tolerants.
2.3 Conclusions
- Els receptors estables d'un transplantament de fetge en monoteràpia amb sirolimus presenten un increment significatiu de la població TregFoxp3+ respecte tractament amb CsA.
¬- El perfil d'expressió en sang perifèrica del pacients tractats amb sirolimus mostra un enriquiment en vies metabòliques pro-inflamatòries i gens involucrats ambla senyalització mTOR.
-IPA-Tox identifica, entre les respostes farmacològiques prèviament definides, a NFκB com la via de senyalització més toxicològica a partir dels gens diferentment expressats.
- L'aplicació d'una signature de tolerància operacional prèviament definida no és capaç d'identificar diferències entre els pacients tractats amb CsA i els que reben sirolimus.
Ahmed, Irfan. "Improved techniques of organ preservation in transplantation." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423000.
Full textCohen, Bernard. "Balancing supply and demand in organ transplantation." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=6980.
Full textMotallebzadeh, Reza. "Tertiary lymphoid organogenesis in solid organ transplantation." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608121.
Full textFalconer, Stuart John. "Tacrolimus pharmacogenomics in abdominal solid organ transplantation." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31355.
Full textChoice, Edward G. "Liposomal immunosuppressants for the management of organ transplantation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0032/NQ27119.pdf.
Full textBrady, Kathryn Marie. "Organ Transplantation: The Ethos of Human Body Parts." Thesis, Boston College, 2007. http://hdl.handle.net/2345/513.
Full textA bioethics thesis focusing on the issues of organ transplantation and the organ trade in the nations of China and India. It explains how the organ transplantation procedure is done, the laws pertaining to organ transplantation, the ethics of organ transplantation, the organ trade in its various aspects in the nations of China and India, and finally shares the story of a living organ donor in the United States. It addresses questions such as: How do we classify brain death? Who should be allowed to donate their organs? Should organs be available for sale and purchase? Is the organ trade a violation human rights? It concludes with the author's opinions on the subject, which are decidedly against the organ trade
Thesis (BS) — Boston College, 2007
Submitted to: Boston College. College of Arts and Sciences
Discipline: Biology
Discipline: College Honors Program
Braggs-Brown, Angela. "Effect of Race on Organ Recovery and Transplantation." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397733817.
Full textKoshiba, Takaaki. "Implication of immunosuppression in tolerance after organ transplantation." Kyoto University, 2003. http://hdl.handle.net/2433/148727.
Full textCabaniss, Thomas Ervin. "The pastor's ministry to people facing organ transplantation." Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.
Full textWaller, Karen. "Infectious diseases in solid organ donation and transplantation." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29196.
Full textPoliachik, Sandra Louise. "Transplant organ preservation cooler." Thesis, Virginia Tech, 1991. http://hdl.handle.net/10919/41591.
Full textMaster of Science
Wortman, Morris Rachel. "Facing the Waitlist: Visual Grammars of Organ Donation and Transplantation." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338035019.
Full textLabuschagne, Debbie. "An analysis of organ transplantation in South Africa with specific reference to organ procurement." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40613.
Full textDissertation (LLM)--University of Pretoria, 2013.
gm2014
Public Law
unrestricted
Honey, Karen J. "Mechanisms of transplantation tolerance." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301519.
Full textHesselink, Dennis Alexander. "Optimization of calcineurin inhibitor treatment after solid organ transplantation." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10510.
Full textGieschen-Krische, Mary. "The role of NKT cells following solid organ transplantation." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-nkt-cells-following-solid-organ-transplantation(321a0a4b-336e-44dd-a608-58f7ea58e27e).html.
Full textDare, Anna Jane. "Targeting mitochondria during ischaemia-reperfusion injury in organ transplantation." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708069.
Full textSpirig, Rolf. "Role and modulation of dendritic cells in organ transplantation /." [S.l.] : [s.n.], 2009. http://www.zb.unibe.ch/download/eldiss/09spirig_r.pdf.
Full textO'Brien, Geraldine. "The lived experience of organ transplantation: Miracle or medicine?" Thesis, O'Brien, Geraldine (2014) The lived experience of organ transplantation: Miracle or medicine? PhD thesis, Murdoch University, 2014. https://researchrepository.murdoch.edu.au/id/eprint/27869/.
Full textAkhtar, Mohammed Zeeshan. "Improving the outcomes of kidney transplantation from deceased organ donors." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:cd7c49f5-e5ce-415b-bdcb-7b59197bc1d0.
Full textEriksson, Leif. "Lung transplantation clinical and experimental studies /." Lund : Depts. of Cardiothoracic Surgery, Respiratory Medicine and Clinical Physiology, University of Lund, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39068785.html.
Full textForsythe, John L. R. "Markers of immune activation following renal transplantation." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241290.
Full textChan, Hoi-sing Peter. "Psychosocial outcomes of living donors after living donor liver transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29760318.
Full textKarlsson, Sophie, and Johanna Stenberg. "Den ständiga väntan på en livsförändring : Patienters erfarenheter av att vänta på en organtransplantation - en litteraturstudie." Thesis, Högskolan i Gävle, Medicin- och vårdvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22972.
Full textBackground: The number of patients waiting for an organ transplant has increased steadily for the past decades. A prerequisite for a successful transplantation program is of course that the demand for organs gets saturated by a steady supply of the same. This is unfortunately not the case as the gap between supply and demand is increasing, hence prolonging waiting times and negatively effecting the patients’ health and overall prognosis. Aim: Portrait the experiences of patients waiting for an organ transplant as well as conducting a methodological examination of the data collection method used in a selection of articles. Method: A descriptive literature that has examined 13 articles, the majority of articles were qualitative design. Results: Patients' experiences when waiting for an organ transplant is often associated with feelings such as anxiety and depression. Patients experiencing the waiting time to get an organ transplant as long and the experience is that the patient’s life is paused. Experiences which patients describes is that support from family and healthcare professionals are of great importance. Even to meet with other patients waiting for an organ transplant was considered as a support for patients. Patients described that experience of getting information from medical staff about his health situation was important for the patients. The articles selected data collection method consisted of 11 qualitative interview study. Two of the articles had quantitative design where surveys have been used. Conclusion: Patients waiting to undergo an organ transplant often have experience of waiting times are long and with time these patients are anxious and fearful. The patients experienced the support from medical staff is important to the care process and that nurses therefore have an important responsibility to adapt care to individual patient needs.
Koulmanda, Maria. "Transplantation of organ cultured foetal islets of Langerhans in mice." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29492.
Full textSikirić, Mina. "Livet efter en transplantation : Att leva med ett nytt organ." Thesis, Högskolan i Borås, Institutionen för Vårdvetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-18788.
Full textProgram: Sjuksköterskeutbildning
Uppsatsnivå: C
Lan, Qing. "Organ Viability Assessment in Transplantation based on Data-driven Modeling." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97126.
Full textDoctor of Philosophy
Organ transplantation is the ultimate solution to save end-stage patients with one or more organ failures. However, the inadequate organs for transplantation to meet the demands has been the major issue. Even worse, the lack of accurate and non-invasive viability assessment methods wastes 20% of donor organs every year. Currently, the most frequently used organ assessment methods are visual inspections and biopsy. Yet both methods are subjective: the assessment accuracy depends on the personal experience of evaluator. Moreover, repeating biopsies will potentially damage the organs. As a result, online non-invasive and quantitative organ assessment methods are in great needs. It is extremely important because such methods will increase the organ utilization rate by saving more discarded organs with transplantation potential. The overall objective of this dissertation is to advance the knowledge on modeling organ viability by developing online non-invasive and quantitative methods to predict and forecast the viability of heterogeneous organs in transplantation. After an introduction in Chapter 1, four research tasks are investigated. In Chapter 2, quantitative and qualitative models jointly predicting porcine liver viability are proposed based on features from biopsy images to validate the biopsy results. In Chapter 3, a multi-task learning logistic regression model is proposed to assess the cross-liver viability by correlating liver viability with spatial infrared data validated by porcine livers. In Chapter 4, a spatial-temporal smooth variable selection is proposed to predict liver viability by considering both spatial and temporal correlations in modeling without feature engineering, which is also validated by porcine livers. In addition, the variable selection results provide medical interpretations by capturing the significant regions on the liver in predicting viability. In Chapter 5, a multitask general path model is proposed to forecast kidney viability validated by porcine kidney. This forecasting method is generalized to apply to needle biopsy tissue deformation case study with the objective to improve the needle insertion accuracy. Finally, I summarize the research contribution and discuss future research directions in Chapter 6. The proposed data-driven methods can predict and forecast organ viability without damaging the organ. As a result, the increased utilization rate of donor organs will benefit more patients by dramatically extending their life spans and bringing them back to normal daily activities.
Fisher, Karen Joan. "Allocating scarce resources an ethical case study of organ transplantation /." Theological Research Exchange Network (TREN), 1997. http://www.tren.com.
Full textMoloney, Gail. "Dynamic contradictions: Social representations, symbolism, and organ donation and transplantation." Thesis, Moloney, Gail (2002) Dynamic contradictions: Social representations, symbolism, and organ donation and transplantation. PhD thesis, Murdoch University, 2002. https://researchrepository.murdoch.edu.au/id/eprint/51279/.
Full textPleass, Henry. "Xenotransplantation : an investigation of cell-mediated rejection within a porcine xenograft model." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321309.
Full textAhmiedat, Hamdi H. "Induction of transplantation tolerance using monoclonal antibodies to CD4 : experimental studies using a rat heterotopic cardiac allograft model." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241856.
Full textCartaya, Rafael Eduardo Chavez. "Study on liver ischaemia and reperfusion." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388665.
Full textBoldra, Denise Carole. "Factors affecting human B lymphocyte stimulation in organ graft recipients." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282735.
Full textMcGregor, Lesley M. "An investigation into the functional and psychosocial impact of living organ donation." Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/2338.
Full textYoshikawa, Tetsushi. "Human herpesvirus 6 iInfection in transplantation." Nagoya University School of Medicine, 2001. http://hdl.handle.net/2237/5363.
Full textBai, Xuemai. "Measurements of thermal properties and analysis of heat transfer in organ cryopreservation." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239211.
Full textHaddow, Gillian. "Organ donation and transplantation : the paradox of gifting and dis/embodiment." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/28173.
Full textMcKay, Lindsey. "Seeking to cure by replacement, the political economy of organ transplantation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ57708.pdf.
Full textPopoola, Joyce. "A study of natural killer cells in allogeneic solid organ transplantation." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430816.
Full textMcKay, Lindsey (Lindsey Colleen) Carleton University Dissertation Political Economy. "Seeking to cure by replacement: the political economy of organ transplantation." Ottawa, 2001.
Find full textBalupuri, Shlokarth. "Evaluation of sub-optimal renal grafts and assessment of viability prior to transplantation." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273496.
Full textHing, Alfred Victor Chang Cardiac Research Institute Faculty of Medicine UNSW. "Optimising the quality of donor organs for transplantation: studies of hormone resuscitation of the brain-dead multi-organ donor and the development of a long-term preservation strategy to optimise function of the transplanted heart in a porcine model." Awarded by:University of New South Wales. Victor Chang Cardiac Research Institute, 2009. http://handle.unsw.edu.au/1959.4/44792.
Full textAlsughayyir, Jawaher. "Humoral alloimmunity in cardiac allograft rejection." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/286971.
Full textGilot, Bryant Joseph. "Visualisation of cytotoxic T cells during allograft rejection and tolerance." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326006.
Full text