Academic literature on the topic 'Organ transplantation'
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Journal articles on the topic "Organ transplantation"
Tumin, Makmor, Khaled Tafran, Wan Ahmad Hafiz Wan Md Adnan, and Ahmad Farid Osman. "Assessing Countries’ Deceased Organ Donation and Transplantation Performance." MARCH 2023 19, no. 2 (March 13, 2023): 170–74. http://dx.doi.org/10.47836/mjmhs.19.2.25.
Full textVukovic, Milivoje, Nebojsa Moljevic, Zoran Milosevic, Nenad Katanic, and Dragan Krivokuca. "Multiple organ procurement." Medical review 60, no. 7-8 (2007): 339–42. http://dx.doi.org/10.2298/mpns0708339v.
Full textMilijić, Svetlana, and Aleksandar Nikolić. "Ethics in Organ Transplantation." Acta Facultatis Medicae Naissensis 35, no. 2 (June 1, 2018): 87–93. http://dx.doi.org/10.2478/afmnai-2018-0010.
Full textOpoku, John Kwaku. "ORGAN TRANSPLANTATION MEDICINE: RELIGIOUS AND ETHICAL CONSIDERATIONS." Volume-1: Issue-9 (November, 2019) 1, no. 9 (December 7, 2019): 13–21. http://dx.doi.org/10.36099/ajahss.1.9.2.
Full textN.V. Kuznetsova, N. V. x., and A. I. Merzlyakova. "COMPARATIVE ANALYSIS OF THE LEGAL REGULATION OF ORGAN DONATION IN THE RUSSIAN FEDERATION, SWITZERLAND AND THE UNITED STATES OF AMERICA." Bulletin of Udmurt University. Series Economics and Law 32, no. 6 (November 24, 2022): 1088–93. http://dx.doi.org/10.35634/2412-9593-2022-32-6-1088-1093.
Full textGautier, S. V., and S. M. Khomyakov. "Organ donation and transplantation in the Russian Federation in 2016 9th report of the National Registry." Russian Journal of Transplantology and Artificial Organs 19, no. 2 (June 23, 2017): 6–26. http://dx.doi.org/10.15825/1995-1191-2017-2-6-26.
Full textKovtun, G. I., B. M. Todurov, and O. A. Kanyura. "History and actual problems of organ donation." Cardiac surgery and interventional cardiology, no. 1-2 (September 19, 2023): 5–14. http://dx.doi.org/10.31928/2305-3127-2023.1-2.514.
Full textGlyantsev, S. P. "Phenomenon of Demikhov. In the Sklifosovsky Institute (1960–1986). Fighting "windmills" or lack of conditions (1961)." Transplantologiya. The Russian Journal of Transplantation 10, no. 4 (December 21, 2018): 336–46. http://dx.doi.org/10.23873/2074-0506-2018-10-4-336-346.
Full textTokalak, Ibrahim, Hamdi Karakayali, Gökhan Moray, Nevzat Bilgin, and Mehmet Haberal. "Coordinating Organ Transplantation in Turkey: Effects of the National Coordination Center." Progress in Transplantation 15, no. 3 (September 2005): 283–85. http://dx.doi.org/10.1177/152692480501500313.
Full textRodrigues-Filho, Edison Moraes, Cristiano Augusto Franke, and José Roque Junges. "Lung transplantation and organ allocation in Brazil." Revista de Saúde Pública 53 (March 7, 2019): 23. http://dx.doi.org/10.11606/s1518-8787.2019053000445.
Full textDissertations / Theses on the topic "Organ transplantation"
Desai, Rajeev Ramarao. "Organ transplantation related cancer." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6907/.
Full textPummer-Verté, Lila. "Organ donation and transplantation /." Online version of thesis, 1995. http://hdl.handle.net/1850/12252.
Full textRuers, Theodoor Jacques Marie. "Selective immunosuppression in organ transplantation." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=5415.
Full textHardstaff, Ruth. "Compliance post solid organ transplantation." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493240.
Full textShubane, Nancy. "Black critical care nurses' perceptions of organ donation and organ transplantation." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-10262009-185326/.
Full textPuig-Pey, Comas Isabel. "Phenotypic and Transcriptional Biomarkers In Organ Transplantation." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/927.
Full text1. Characterization of gamma-delta-T cell subsets in organ transplantation
gamma-delta-T cells are innate-type lymphocytes that preferentially act as regulators of local effector immune responses. Recent reports found an altered distribution of the two main subpopulations of blood gamma-delta-T cells (V-delta-1 and V-delta-2) in operationally tolerant liver transplant recipients. Based on this, gamma-delta-T cells subset quantification was proposed as a biomarker of immunologic risk in liver transplantation. The specific characteristics of gamma-delta-T cell subsets in transplantation remain however unknown. We have investigated here the phenotype, repertoire and functional properties of gamma-delta-T cell subsets in a large population of allograft recipients. Our results indicate that alterations in the gamma-delta-T cell compartment are not restricted to tolerant liver recipients. In fact, most immunosuppressed liver and kidney recipients also display an enlarged peripheral blood gamma-delta-T cell pool mainly resulting from an expansion of V-delta-1 T cells exhibiting an oligoclonal repertoire and different phenotypic and cytokine production traits than V-delta-2 T cells. We propose that persistent viral infections are likely to contribute to these alterations. Our data provide novel insight in the biology of gamma-delta-T cells and a rationale for exploring these lymphocytes in more depth into the pathogenesis of viral infections in transplantation.
2. Comparative Transcriptional and Phenotypic Peripheral Blood Analysis of Kidney Recipients under Cyclosporin A or Sirolimus Monotherapy
Due to its low level of nephrotoxicity and capacity to harness tolerogenic pathways, sirolimus (SRL) has been proposed as an alternative to calcineurin inhibitors in organ transplantation. However, the exact mechanisms underlying its unique immunosuppressive profile in humans are still not well understood. In the current study, we aimed to depict the in vivo effects of SRL in comparison with cyclosporine A (CSA) by employing gene expression profiling and multiparameter flow cytometry on blood cells collected from stable kidney recipients under monotherapy with either SRL or CSA. In addition, the overall effect of these drugs on immunoregulatory pathways was assessed by measuring a transcriptional signature characteristic of operationally tolerant kidney recipients. Samples from SRL recipients displayed an increased frequency of effector memory T cells and were enriched in NFkB-related pro-inflammatory expression pathways and in monocyte and NK cell lineage-specific transcripts. Furthermore neither SRL nor CSA induced a gene expression profile comparable with that of tolerant kidney recipients. In conclusion, we show here that the overall pattern of SRL effect in vivo is dominated by innate immune cells and NFkB-related pro-inflammatory events. These data provide novel insights on the complex effects of SLR on the immune system in clinical transplantation.
"Biomarcadors fenotípics i transcripcionals
en el transplantament d'òrgans"
TEXT:
1. Estudi de les cèl·lules T gamma-delta A l'al·lotransplantament d'òrgans
1.1 Objectius
- Investigació detallada de la freqüència, fenotip, repertori del TCR i característiques funcionals de les poblacions Vdelta1 i Vdelta2 en sang perifèrica en trasplantats.
- Determinar si l'òrgan trasplantat, la teràpia immunosupressora i la presència d'infeccions víriques influeixen en la distribució i propietats de les subpoblacions gamma-delta.
- Avaluar el valor clínic de la quantificació de les cèl·lules T gamma-delta com a biomarcador diagnòstic de trasplantats tolerants operacionals de fetge.
1.2 Resultats
Es van quantificar les poblacions de gamma-delta totals, Vdelta1, Vdelta2 i ràtio Vdelta1/Vdelta2 en 201 trasplantats de fetge estables (STA-Liver), 29 tolerants operacionals trasplantats de fetge (TOL), 50 trasplantats estables de ronyó (STA-Kidney), 50 malalts amb insuficiència hepàtica terminal (ESLD) i 34 controls sans (CONT). Vem observar un increment de la població gamma-delta total en tots els grups de pacients trasplantats respecte CONT, que venia determinat per un increment de la població Vdelta1, més significatiu en el cas dels TOL, i una disminució de Vdelta2.
Vem demostrar que les freqüències del fenotip són estables en el temps determinant el percentatge d'expressió de Vdelta1 i Vdelta2 dues vegades amb 14 mesos de diferència.
El fenotipatge realitzat a les poblacions Vdelta1 i Vdelta2 en 19 pacients STA-Liver, va mostrar que aquestes subpoblacions expressen marcadors cel·lulars de superfície, intracel·lulars i funcionals diferents entre si. Aquests marcadors, però no serviren per diferenciar una cohort de 9 TOL i 10 STA-Liver. Vàrem assajar la utilitat diagnòstica dels percentatges de Vdelta1 i Vdelta2 per diferenciar TOL i STA-Liver utilitzant una corba ROC. Els resultats no varen ser positius.
Vam correlacionar la freqüència d'infeccions víriques persistents amb la distribució de les subpoblacions T gamma-delta. CMV i HCV, provocaven una alteració independent entre si i significativa en el ràtio Vdelta1/Vdelta2. Vam estudiar, finalment la diversitat clonal del TCR de la població Vdelta1. Es va clonar i seqüenciar la CDR3 del TCR Vdelta1. Els TOL mostren una tendència, estadísticament significativa, cap a un repertori restringit del TCR Vdelta1. Vam determinar si aquestes seqüències de nucleòtids es traduïen en grups d'aminoàcids compartits en la CDR3 de V1 però el resultat fou negatiu.
1.3. Conclusions
- La majoria dels receptors d'un transplantament mostren un increment en sang perifèrica de la població de cèl·lules T gamma-delta.
- La distribució alterada en sang perifèrica de les subpoblacions T gamma-delta és estable en un període de temps establert.
- Les infeccions per CMV i HCV afecten la freqüència relativa de les subpoblacions gamma-delta i el ràtio Vdelta1/Vdelta2 en sang perifèrica en pacients trasplantats de fetge.
- Les cèl·lules T Vdelta1 mostren ser fenotípica i funcionalment diferents de les Vdelta2.
- El repertori de CDR3 del receptor de les cèl·lules T Vdelta1 està restringit en receptors de fetge tolerants operacionals.
- Ni la quantificació de subpoblacions T gamma-delta ni la seva caracterització fenotípica permeten discriminar de forma acurada entre TOL i els STA-Liver.
2. Anàlisi fenotípic i transcripcional de receptors d'un transplantament de ronyó en monoteràpia amb CsA o sirolimus
2.1 Objectius
- Establir els efectes in vivo de sirolimus i CsA en sang perifèrica utilitzant tècniques de cribatge d'alt rendiment, per generar un perfil fenotípic i transcripcional de les dues cohorts de pacients.
- Determinar l'expressió d'una sèrie de biomarcadors associats a tolerància en aquests pacients, a partir d'un perfil generat anteriorment en tolerants operacionals renals.
2.2 Resultats
Es varen determinar les diferències fenotípiques de les dues cohorts i vàrem determinar que els pacients tractats amb sirolimus (SRL) mostraven un increment en la població CD4 de memòria efectora (CD45RA-CCR7-) respecte els pacients CSA. El grup SRL també presentava un increment en l'expressió de cèl·lules Tregs (CD4+CD25highFoxp3+) comparat amb CSA.
Vam fer estudis de microarray d'Affymetrix a partir de sang perifèrica. Vam fer un anàlisi comparatiu de dades utilitzant SAM (FDR<5%). El resultat d'aquest anàlisi ens va permetre identificar un total de 486 gens upregulated i 586 gens downregulated en el grup SRL respecte CSA.
Per interpretar el conjunt de gens diferentment expressats vam utilitzar el mètode GSEA, que ens va permetre identificar un enriquiment en el grup SRL de vies de senyalització relacionades amb mTOR i vies pro-inflamatòries comparat tant amb CSA com amb el grup d'individus sans.
Utilitzant Haematolgy Expression Atlas vam identificar una representació significativa de trànscrits específics per monòcits i cèl·lules NK en SRL, i per cèl·lules T CD4+ i limfòcits B en el grup CSA.
El software IPA-Tox va identificar NFκB com la via de senyalització més representativa respecte els gens estudiats.
Per últim vàrem determinar la prevalença de biomarcadors relacionats amb tolerància operacional en pacients trasplantats de ronyót. Dels 37 pacients estudiats només 1 SRL i 3 CSA varen ser predits com a potencialment tolerants.
2.3 Conclusions
- Els receptors estables d'un transplantament de fetge en monoteràpia amb sirolimus presenten un increment significatiu de la població TregFoxp3+ respecte tractament amb CsA.
¬- El perfil d'expressió en sang perifèrica del pacients tractats amb sirolimus mostra un enriquiment en vies metabòliques pro-inflamatòries i gens involucrats ambla senyalització mTOR.
-IPA-Tox identifica, entre les respostes farmacològiques prèviament definides, a NFκB com la via de senyalització més toxicològica a partir dels gens diferentment expressats.
- L'aplicació d'una signature de tolerància operacional prèviament definida no és capaç d'identificar diferències entre els pacients tractats amb CsA i els que reben sirolimus.
Ahmed, Irfan. "Improved techniques of organ preservation in transplantation." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423000.
Full textCohen, Bernard. "Balancing supply and demand in organ transplantation." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2001. http://arno.unimaas.nl/show.cgi?fid=6980.
Full textMotallebzadeh, Reza. "Tertiary lymphoid organogenesis in solid organ transplantation." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608121.
Full textFalconer, Stuart John. "Tacrolimus pharmacogenomics in abdominal solid organ transplantation." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31355.
Full textBooks on the topic "Organ transplantation"
Klein, Andrew, Clive Lewis, and Joren C. Madsen, eds. Organ Transplantation. Cambridge: Cambridge University Press, 2011. http://dx.doi.org/10.1017/cbo9780511994876.
Full textF, Cardella John, and Amplatz Kurt, eds. Organ transplantation. Philadelphia: Saunders, 1987.
Find full textJ, Roberts Arthur, and Painvin G. Arnaud, eds. Organ transplantation. Philadelphia: Saunders, 1986.
Find full textWest, Richard. Organ transplantation. London: Office of Health Economics, 1991.
Find full textM, Abouna George J., Kumar M. S. A, and White Arthur G, eds. Organ transplantation 1990. Dordrecht: Kluwer Academic Publishers, 1991.
Find full textMamode, Nizam, and Raja Kandaswamy, eds. Abdominal Organ Transplantation. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118483664.
Full textAbouna, G. M., M. S. A. Kumar, and A. G. White, eds. Organ Transplantation 1990. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3386-9.
Full textH, Toledo-Pereyra Luis, ed. Organ preservation for transplantation. 3rd ed. Austin, Tex: Landes Bioscience, 2010.
Find full textG, Gruessner Rainer W., and Benedetti E, eds. Living donor organ transplantation. New York: McGraw-Hill, Health Professions Division, 2008.
Find full text1926-, Starzl Thomas E., Shapiro Ron 1954-, and Simmons Richard L. 1934-, eds. Atlas of organ transplantation. New York: Gower Medical Pub., 1992.
Find full textBook chapters on the topic "Organ transplantation"
Ata, Barış, John J. Friedewald, and A. Cem Randa. "Organ Transplantation*." In Handbook of Healthcare Analytics, 187–215. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781119300977.ch9.
Full textIltis, Ana S. "Organ Transplantation." In Encyclopedia of Global Bioethics, 1–11. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-05544-2_317-1.
Full textDeutsch, Erwin, and Hans-Ludwig Schreiber. "Organ Transplantation." In Medical Responsibility in Western Europe, 674–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70449-9_71.
Full textZaidi, Shabih H. "Organ Transplantation." In Ethics in Medicine, 197–210. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01044-1_7.
Full textEllis, Harold, and Sala Abdalla. "Organ transplantation." In A History of Surgery, 237–47. Third edition. | Boca Raton, Florida: CRC Press, [2019] |: CRC Press, 2018. http://dx.doi.org/10.1201/9780429461743-15.
Full textIltis, Ana S. "Organ Transplantation." In Encyclopedia of Global Bioethics, 2073–82. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-09483-0_317.
Full textAl-Bar, Mohammed Ali, and Hassan Chamsi-Pasha. "Organ Transplantation." In Contemporary Bioethics, 209–25. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18428-9_13.
Full textStauch, Marc, and Kay Wheat. "Organ transplantation." In Text, Cases and Materials on Medical Law and Ethics, 537–90. Sixth edition. | Milton Park, Abingdon, Oxon ; New York, NY : Routledge, [2019]: Routledge, 2018. http://dx.doi.org/10.4324/9781315168326-11.
Full textKirnap, Mahir, and Mehmet Haberal. "Organ Preservation." In Transplantation Surgery, 89–102. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55244-2_6.
Full textSpiegel, Hans U., and Daniel Palmes. "Organ Preservation." In Transplantation Surgery, 265–94. London: Springer London, 2001. http://dx.doi.org/10.1007/978-1-4471-3689-7_13.
Full textConference papers on the topic "Organ transplantation"
Pritsker, A. Alan B., Michael E. Kuhl, John P. Roberts, Margaret D. Allen, James F. Burdick, David L. Martin, Janet S. Reust, et al. "Organ transplantation policy evaluation." In the 27th conference. New York, New York, USA: ACM Press, 1995. http://dx.doi.org/10.1145/224401.224813.
Full textMladenović, Tamara. "Etički i pravni aspekti uzimanja organa od umrlih maloletnih lica." In XVI Majsko savetovanje. University of Kragujevac, Faculty of Law, 2020. http://dx.doi.org/10.46793/upk20.483m.
Full textMladenović, Tamara. "Etički i pravni aspekti uzimanja organa od umrlih maloletnih lica." In XVI Majsko savetovanje. University of Kragujevac, Faculty of Law, 2020. http://dx.doi.org/10.46793/upk20.483m.
Full textWang, Jinguo, and Na Wang. "Organ Transplantation and Relevant Law." In 2016 International Conference on Education, Management Science and Economics. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/icemse-16.2016.72.
Full textŽivojinović, Dragica. "NAČELA POSTUPKA PRESAĐIVANjA LjUDSKIH ORGANA U SRPSKOM PRAVU." In XVIII Majsko savetovanje. University of Kragujevac, Faculty of Law, 2022. http://dx.doi.org/10.46793/xviiimajsko.587z.
Full textRao, Vinaya, Ravi S. Behara, and Ankur Agarwal. "Predictive Modeling for Organ Transplantation Outcomes." In 2014 IEEE International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2014. http://dx.doi.org/10.1109/bibe.2014.58.
Full textNazarov, V. V., and A. K. Martusevich. "MICROWAVE MONITORINGOF ORGAN VIABILITY DURING TRANSPLANTATION." In Terahertz and Microwave Radiation: Generation, Detection and Applications (ТЕRА-2023). Moscow: Our Style, 2023. http://dx.doi.org/10.59043/9785604953914_74.
Full textNaveed, Khushbakht, Zofishan Hameed, Aqsa Khalid, Adeena Hamid, Beenish Fatima, and Amna Batool. "Exploratory study on organ donation and organ transplantation in Pakistan." In ICTD '19: Tenth International Conference on Information and Communication Technologies and Development. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3287098.3287145.
Full textSrilatha, P., K. Siri Reddy, A. Sruthi Reddy, Devarasetty Kedhar, and Moru Bhavana. "Organ Connect: A Digital Platform for Organ Donation and Transplantation." In 2023 3rd International Conference on Innovative Mechanisms for Industry Applications (ICIMIA). IEEE, 2023. http://dx.doi.org/10.1109/icimia60377.2023.10426416.
Full textV, Siva Sankar, and Sukanya S. T. "Using Hashing Algorithm for the Organ Procurement and Transplant Network." In The International Conference on scientific innovations in Science, Technology, and Management. International Journal of Advanced Trends in Engineering and Management, 2023. http://dx.doi.org/10.59544/slmx2075/ngcesi23p55.
Full textReports on the topic "Organ transplantation"
Basu, Sayani. Organ Transplantation: A New Lease of Life. Science Repository, February 2021. http://dx.doi.org/10.31487/sr.blog.24.
Full textFallon, John, Richard Dumbill, and Peter Friend. Organ preservation in renal transplantation. BJUI Knowledge, September 2023. http://dx.doi.org/10.18591/bjuik.0753.
Full textCallison, Kevin, Michael Darden, and Keith Teltser. Externalities from Medical Innovation: Evidence from Organ Transplantation. Cambridge, MA: National Bureau of Economic Research, September 2023. http://dx.doi.org/10.3386/w31673.
Full textDe Mel, Stephanie, Kaivan Munshi, Soenje Reiche, and Hamid Sabourian. Herding with Heterogeneous Ability: An Application to Organ Transplantation. Cambridge, MA: National Bureau of Economic Research, October 2021. http://dx.doi.org/10.3386/w29412.
Full textWang, Li Fang, Yan Ting Cao, Tegeleqi Bu, Lin Fu, Jun Li Liu, and Jing Zhao. Do We Receive Cytomegalovirus Vaccination Before Solid Organ Transplant: a Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0143.
Full textBornholz, Robert, and James Heckman. Measuring Disparate Impacts and Extending Disparate Impact Doctrine to Organ Transplantation. Cambridge, MA: National Bureau of Economic Research, December 2004. http://dx.doi.org/10.3386/w10946.
Full textKaufman, Christina L. Positioning Vascularized Composite Allotransplantation within the Spectrum of Solid Organ Transplantation. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada618393.
Full textzhang, mingxiong, xiang ma, xuejun wang, guiting zhang, mengqiu zheng, weihao ma, and youguo dai. Effect of Remote Ischemic Conditioning on organ transplantation: a meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2023. http://dx.doi.org/10.37766/inplasy2023.5.0056.
Full textGoodmonson, Courtney. Donation of organs for transplantation : an investigation of attitudes and behavior. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.454.
Full textJin, Dachuan, Zhongfeng Cui, Tao Zhou, Baoqiang Guo, Shunqin Jin, Guangming Li, and Chunming Zhang. Comparison of therapeutic effects of various stem cell types, sources, and routes of administration on chronic decompensated cirrhosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0050.
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