Academic literature on the topic 'Orf121'
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Journal articles on the topic "Orf121":
Rziha, Hanns-Joachim, Mathias Büttner, Melanie Müller, Ferdinand Salomon, Alena Reguzova, Dominic Laible, and Ralf Amann. "Genomic Characterization of Orf Virus Strain D1701-V (Parapoxvirus) and Development of Novel Sites for Multiple Transgene Expression." Viruses 11, no. 2 (January 30, 2019): 127. http://dx.doi.org/10.3390/v11020127.
Tang, Ruizhe, Liqun Lu, Beiyang Wang, Jiao Yu, and Hao Wang. "Identification of the Immediate-Early Genes of Cyprinid Herpesvirus 2." Viruses 12, no. 9 (September 7, 2020): 994. http://dx.doi.org/10.3390/v12090994.
Gong, Min, Jianping Jin, and Linda A. Guarino. "Mapping of ORF121, a Factor That Activates Baculovirus Early Gene Expression." Virology 244, no. 2 (May 1998): 495–503. http://dx.doi.org/10.1006/viro.1998.9116.
Che, Xibing, Mike Reichelt, Marvin H. Sommer, Jaya Rajamani, Leigh Zerboni, and Ann M. Arvin. "Functions of the ORF9-to-ORF12 Gene Cluster in Varicella-Zoster Virus Replication and in the Pathogenesis of Skin Infection." Journal of Virology 82, no. 12 (April 9, 2008): 5825–34. http://dx.doi.org/10.1128/jvi.00303-08.
Kessler, Peter S., Carrine Blank, and John A. Leigh. "The nif Gene Operon of the Methanogenic Archaeon Methanococcus maripaludis." Journal of Bacteriology 180, no. 6 (March 15, 1998): 1504–11. http://dx.doi.org/10.1128/jb.180.6.1504-1511.1998.
Gao, Wa, Lupin Zhao, Yihua Zheng, Kaixuan Wu, Feiyang Xu, Hao Wang, Liqun Lu, and Yousheng Jiang. "Generation and application of a monoclonal antibody specific for the ORF121 of cyprinid herpesvirus 2." Journal of Fish Diseases 45, no. 3 (December 6, 2021): 387–94. http://dx.doi.org/10.1111/jfd.13566.
Kolosov, A. V., V. A. Ternovoy, A. N. Shvalov, A. A. Moiseeva, A. S. Safatov, and V. N. Mikheev. "ADAPTATION OF THE CORN EARWORM SINGLE NUCLEOCAPCIDE NUCLEOPOLYHEDROVIRUS (HELICOVERPA ZEA SNPV) FOR THE CONTROL OF THE COTTON BOLLWORM (HELICOVERPA ARMIGERA) POPULATION." Problems of Virology, Russian journal 62, no. 3 (June 20, 2017): 134–37. http://dx.doi.org/10.18821/0507-4088-2017-62-3-134-137.
Martínez-Costa, Oscar H., Angel J. Martín-Triana, Eduardo Martínez, Miguel A. Fernández-Moreno, and Francisco Malpartida. "An Additional Regulatory Gene for Actinorhodin Production in Streptomyces lividans Involves a LysR-Type Transcriptional Regulator." Journal of Bacteriology 181, no. 14 (1999): 4353–64. http://dx.doi.org/10.1128/jb.181.14.4353-4364.1999.
Tan, Yeping, Dennis K. Bideshi, Jeffrey J. Johnson, Yves Bigot, and Brian A. Federici. "Proteomic analysis of the Spodoptera frugiperda ascovirus 1a virion reveals 21 proteins." Journal of General Virology 90, no. 2 (February 1, 2009): 359–65. http://dx.doi.org/10.1099/vir.0.005934-0.
Li, Ping, Shanghai Yong, Xin Zhou, and Jiayin Shen. "Characterization of a New Temperate Escherichia coli Phage vB_EcoP_ZX5 and Its Regulatory Protein." Pathogens 11, no. 12 (November 30, 2022): 1445. http://dx.doi.org/10.3390/pathogens11121445.
Dissertations / Theses on the topic "Orf121":
Fauconnier, Aurélien. "Étude des modalités de transposition des séquences d'insertion bactériennes des familles IS91-ISCR." Electronic Thesis or Diss., Limoges, 2023. http://www.theses.fr/2023LIMO0101.
The IS91/ISCR family is highly associated with virulence and antibiotic resistance genes. This atypical IS family encodes a HUH transposase mediating transposition events using a rolling circle transposition mechanism. Unlike the other members of the family, IS91 contains a small ORF potentially encoding a 121 amino acid polypeptide, Orf121, upstream of the transposase gene, tnpA. The first part of this work consisted of an in silico study of two members of the IS91 family, IS91 and IS1294b, that have conserved sequences of the transposase and terIS and oriIS regions. The second part of this work was experimental and focused on the transposition efficiency and regulation. We have shown that i) transcription of the tnpA gene originates mainly from the Porf121 promoter and that transcription of the two genes is coupled, ii) expression of the Orf121 protein in cis or in trans has an inhibitory effect on in vivo transposition of IS91, iii) Orf121 is required for recognition and precise cleavage of the terIS91 end to limit mobilization of the adjacent DNA. With regard to IS91 transposition, we showed that only single-stranded circular DNA intermediates can be inserted into a new target sequence and identified two zinc fingers essential for the transposase activity, called ZF1 involving cysteines 41, 68, 73 and 76 and ZF2 involving cysteines 53, 58, 360 and 363. Finally, we demonstrated that transposases from the IS91 family (IS91, ISKnp22) and the ISCR family (ISCR1) are able to mobilize and recognize and cleave the oriIS end of IS91, ISCR1 and ISCR2 and the terIS end of IS91 and ISCR2
Vieira, Débora Fernanda. "Produção e caracterização de enzimas de Streptomyces clavuligerus relacionadas com a síntese do ácido clavulânico." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-20122012-154241/.
Clavulanic acid (CA) is a potent inhibitor of β-lactamases, produced by Streptomyces clavuligerus, clinically used in combination with β-lactam antibiotics to treat resistant bacterial infections. Although CA industrial production is well-established, many important aspects related to its biosynthesis remains under study. It is known that CA pathway involves at least 8 enzymatic steps, being the earliest stages more addressed. For instance, N2-(2-carboxyethyl) arginine synthase (CEAS), β-lactam synthase (BLS) and proclavaminate amidinohydrolase (PAH) are responsible for the first, second and fourth enzymatic reaction, respectively. Recent mutagenic studies in S.clavuligerus have related extra copies of ceas, bls and pah genes ((ceas1, bls1 e pah1) to this pathway but none enzymatic assay was further reported. Although later stages the pathway remain unclear, the action of some putative enzymes like the codified by orf12 showed essential to CA production. Thus, aiming to increase the information available about CA biosynthesis we studied four of its members: CEAS1, BLS1, PAH1, and the putative protein codified by orf12. The genes were isolated from S.clavuligerus genomic DNA by PCR and further cloned into expression vectors in order to produce recombinant proteins in E.coli. Protocols of protein expression were established to CEAS1, PAH1 and ORF12 and recombinant proteins were purified by metal affinity chromatography. BLS was obtained as an insoluble form. Soluble proteins were characterized by means of biochemical and structural approaches. Analyses of CEAS1 and PAH1 were compared with information ever conducted to the isozymes CEAS2 and PAH2, respectively. Thus, oligomerization analysis of proteins resulted respectively in a mix of oligomers forms (monomer, dimer, tetramer) to CEAS1, hexameric form to PAH1 and dimeric form to ORF12, according to the soluble and crystallographic form of CEAS2 (dimer and tetramer) and PAH2 (hexamer). Circular Dichroism spectra showed that CEAS1 and PAH1 have an α-β conformation and were stable up to 35ºC over a wide pH range. Thermodynamic parameters of CEAS1 cofactor (Mg+2) binding were determined showing that is entropic driven, with a 4:1 binding stoichiometry, with a micro-molar affinity (KD = 1.76 ± 0.23 µM). Analyses by coupled assay, High Pressure Liquid Chromatography coupled to Mass Spectroscopy (LC-MS) and Isothermal Titration Calorimetry showed that CEAS1, as well as the CEAS2, presents activity at the substrate glyceraldehydes-3-phosphate, however without formation of final product, N2-(2-carboxyethyl)arginine. Meanwhile recombinant PAH1 showed none activity at analogous substrate, N-α-acetil-L-arginine. Thus despite isozymes maintain a structural pattern, they may have distinct action mechanism. Regards to ORF12, this protein was classified as a β-lactamase with an esterase activity according to our studies performed with the substrates cephalosporin C and p-nitrophenyl acetate.
Fang, Minggang. "The analysis of Autographa Californica multiple Nucleopolyhedrovirus EXONO (ORF141) function and its role in virus budding." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/191.
Lehiy, Christopher J. "A study of two highly conserved baculovirus genes." Diss., Kansas State University, 2010. http://hdl.handle.net/2097/13892.
Department of Biology
A. Lorena Passarelli
Baculoviruses are enveloped, rod shaped viruses with circular, double-stranded DNA genomes. These viruses infect arthropods, primarily in the order Lepidoptera, although members of this virus family also infect species of Diptera, Hymenoptera, and Crustacea. The majority of these viruses undergo a bi-phasic cycle with one phase defined by the production of a budded virus (BV) form, responsible for cell to cell transmission, and the other defined by the production of an occlusion-derived virus (ODV) form, responsible for host to host transmission. The proto-typical member of the Baculoviridae family is considered to be Autographa californicaM Nucleopolyhedrovirus (AcMNPV). Its 133,894 base pair genome is predicted to encode for 156 proteins, a large number of which are essential for virus replication.. In this current work, we have further characterized two viral proteins that are highly conserved among baculoviruses. The first of these is an ortholog of the fibroblast growth factor family of proteins with sequence homology to the Drosophila Branchless protein as well as the mammalian FGF- 9, -16 and -20 subfamily. Despite its high degree of conservation among baculoviruses, the viral fibroblast growth factor (vFGF) is considered a non-essential protein, although its deletion from the genome does affect the lethality of the virus when ingested per os. In our study, we were able to localize vFGF to the membrane of BV. Its presence on the envelope affected the ability of the virus particle to bind to both heparin in vitro and to the cell surface in vivo, and may play a role in the attachment phase prior to virus entry. We also characterized AcMNPV’s open reading frame 109 (Ac-orf109). Unlike vFGF, Ac-orf109 is essential for virus replication since its deletion results in a complete lack of BV production. Transmission electron microscopy of cells transfected with an Ac-orf109 deletion virus shows the full range of virus-associated structures including mature capsid formation but there appears to be a deficiency in capsid egress out of the nucleus. Furthermore, the ODV retained in the nucleus appear to lack microvesicular membranes, an essential component for host to host transmission of infection.
Szczepańska, Agnieszka Katarzyna. "Characterisation of recombination functions of the orf12-15 DNA region from the bIL67 bacteriophage active against Lactococcus lactis subsp. Lactis." Paris 11, 2006. http://www.theses.fr/2006PA112281.
Recombination is involved in key stages of phage multiplication. Due to its importance for phage development, it is postulated that phages do not rely only on host-encoded functions but posses their own recombination proteins. Despite general indications that lactococcal phages can recombine, existence of recombination systems lacked direct proof. Results of this thesis supply evidence of phage bIL67-mediated recombination and studies that led to characterising individual recombination genes in the phage genome. This work presents in a general way that phage bIL67 encodes proteins proficient in promoting recombination. Phage bIL67 was shown to develop and recombine independently of host RecA protein, which suggested the presence of phage-encoded proteins promoting the same events as bacterial recombination proteins. The putative recombination region was defined to orfs12-15 of the early transcribed part of the phage genome. Finding orf13 gene product to be homologous to phage P22 Erf recombinase and an overall organisation similarity with P22 recombination module were the initial evidences suggesting localisation of the putative recombination gene cluster in this region. Identification of orf14-encoded SSB function just upstream of orf13 supplied further proof. Putative recombination region was shown to encode anti-Exo activity acting against main lactococcal Exo protein (RexAB). Molecular characterisation of Orf14 activity in vitro confirmed its affinity for single-stranded nucleic acids. Amino acid substitution of Orf14 led to identification of the functional domains involved in DNA binding and protein-protein interactions. In vivo complementation studies proved Orf14 to partially substitute SSB of E. Coli
Stockmeyer, Kerstin [Verfasser]. "Heterologe Expression und Funktionsanalyse des CMS-assoziierten offenen Leserahmens orf107 aus Sorghum bicolor in Nicotiana tabacum und Arabidopsis thaliana / Kerstin Stockmeyer." Kiel : Universitätsbibliothek Kiel, 2008. http://d-nb.info/1019543426/34.
Okada, Sachiko. "Characterization of the repeat-rich region of the Y chromosome harboring a male-specific gene, ORF162, in the liverwort, Marchantia polymorpha." Kyoto University, 2002. http://hdl.handle.net/2433/149933.
0048
新制・課程博士
博士(農学)
甲第9648号
農博第1276号
新制||農||847(附属図書館)
学位論文||H14||N3680(農学部図書室)
UT51-2002-G406
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 大山 莞爾, 教授 佐藤 文彦, 教授 關谷 次郎
学位規則第4条第1項該当
Diekmann, Ulrike Verfasser], and Lothar [Akademischer Betreuer] [Jänsch. "Characterisation of the KSHV protein ORF20 and its role in innate immunity / Ulrike Diekmann ; Betreuer: Lothar Jänsch." Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/1179909984/34.
Diekmann, Ulrike [Verfasser], and Lothar [Akademischer Betreuer] Jänsch. "Characterisation of the KSHV protein ORF20 and its role in innate immunity / Ulrike Diekmann ; Betreuer: Lothar Jänsch." Braunschweig : Technische Universität Braunschweig, 2019. http://d-nb.info/1179909984/34.
C, G. GUALBERTO JOSE MANUEL. "Etude des genes nad3, rps12, orf156 et coxiii du genome mitochondrial du ble (triticum aestivum) : structure, expression et edition de leurs transcrits." Strasbourg 1, 1990. http://www.theses.fr/1990STR13091.
Books on the topic "Orf121":
Meng, X. J. Hepatitis E virus. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0048.
Book chapters on the topic "Orf121":
Ramos, Kenneth S., Stefano Guerra, and Randa El-Zein. "Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy." In Advancing the Science of Cancer in Latinos, 89–98. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14436-3_8.
Schwindt, Joel. "The mystical architecture of Orfeo1." In Orpheus in the Academy, 172–213. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003029816-7.
Deming, Damon J., Rachel L. Graham, Mark R. Denison, and Ralph S. Baric. "MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication." In Advances in Experimental Medicine and Biology, 101–4. Boston, MA: Springer US, 2006. http://dx.doi.org/10.1007/978-0-387-33012-9_17.
Kumar, Amit, Ajit Kumar Saxena, Gwo Giun (Chris) Lee, Amita Kashyap, and G. Jyothsna. "Physiochemical Characterization and Domain Annotation of ORF1ab Polyprotein of Novel Corona Virus 19." In Novel Coronavirus 2019, 23–35. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7918-9_4.
Wilde, Annegret, Hendrik Schubert, Heiko Härtel, and Thomas Börner. "Alterations of the Photosynthetic Apparatus in a Synechocystis sp. PCC 6803 ORF184 Mutant." In Photosynthesis: from Light to Biosphere, 2437–40. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-009-0173-5_574.
Naufer, M. Nabuan, and Mark C. Williams. "Characterizing Complex Nucleic Acid Interactions of LINE1 ORF1p by Single Molecule Force Spectroscopy." In Methods in Molecular Biology, 283–97. New York, NY: Springer US, 2019. http://dx.doi.org/10.1007/978-1-0716-0231-7_18.
Liu, D. X., S. Shen, H. Y. Xu, and T. D. K. Brown. "Proteolytic Processing of the Polyprotein Encoded by ORF1b of the Coronavirus Infectious Bronchitis Virus (IBV)." In Advances in Experimental Medicine and Biology, 149–59. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5331-1_20.
Hughes, Scott A., Mark R. Denison, Pedro Bonilla, Julian L. Leibowitz, Ralph S. Baric, and Susan R. Weiss. "A Newly Identified MHV-A59 ORF1a Polypeptide p65 is Temperature Sensitive in Two RNA Negative Mutants." In Coronaviruses, 221–26. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2996-5_35.
Liu, D. X., K. W. Tibbles, D. Cavanagh, T. D. K. Brown, and I. Brierley. "Involvement of Viral and Cellular Factors in Processing of Polyprotein Encoded by ORF1a of the Coronavirus IBV." In Advances in Experimental Medicine and Biology, 413–21. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1899-0_67.
Cui, Guanglei, Xue Li, Ning Yu, and Kenneth M. Merz. "Interpreting The Observed Substrate Selectivity And The Product Regioselectivity In Orf2-Catalyzed Prenylation From X-Ray Structures." In Challenges and Advances in Computational Chemistry and Physics, 351–75. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9956-4_13.
Conference papers on the topic "Orf121":
Hajighasemi, F., and A. Shirkavand. "Insilico study of COVID-19 ORF1ab protein allergenicity." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.3367.
Stoicescu, Ramona, Razvan-Alexandru Stoicescu, Codrin Gheorghe, Adina Honcea, and Iulian Bratu. "CONSIDERATIONS ON SARS-COV-2 DIAGNOSIS IN THE LABORATORY OF UNIVERSITY EMERGENCY CLINICAL HOSPITAL OF CONSTANTA." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/07.
Thomas, Michael A., Rui Song, and Marjorie Robert-Guroff. "Abstract 472: Effects of the deletion of early region 4 (E4) open reading frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on virus-host cell interaction, transgene expression, and immunogenicity of replicating adenovirus vaccine vectors." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-472.
Pontes dos Santos, Luiz Henrique, Jannison Karlly Cavalcante Ribeiro, Juliana Osorio Alves, Maria Izabel Florindo Guedes, Stela Mirla da Silva Felipe, Raquel Martins de Freitas, Paula Matias Soares, et al. "SARS-CoV-2 variant strains and viral phylodynamics of ORF1a-1b genetic aspects in South America." In 2021 International Conference on Computational Science and Computational Intelligence (CSCI). IEEE, 2021. http://dx.doi.org/10.1109/csci54926.2021.00034.
Yang, Fan, Hong-Liang Liu, Xiao-Wan Liu, Bo Guo, Song Li, Ping Li, and Ling Zhug. "Development of a TTSuV2-ORF1 Protein-based Indirect Blocking ELISA for Serological Testing." In 2015 International Conference on Medicine and Biopharmaceutical. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789814719810_0023.
Reports on the topic "Orf121":
Mawassi, Munir, and Valerian Dolja. Role of RNA Silencing Suppression in the Pathogenicity and Host Specificity of the Grapevine Virus A. United States Department of Agriculture, January 2010. http://dx.doi.org/10.32747/2010.7592114.bard.