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1
Mutschler, Christopher [Verfasser]. "Latency Minimization of Order-Preserving Distributed Event-Based Systems / Christopher Mutschler." München : Verlag Dr. Hut, 2014. http://d-nb.info/1050331664/34.
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Chen, Weiwei. "Out-of-order Parallel Discrete Event Simulation for Electronic System-Level Design." Thesis, University of California, Irvine, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3597427.
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The large size and complexity of the modern embedded systems pose great challenges to design and validation. At the so called electronic system level (ESL), designers start with a specification model of the system and follow a systematic top-down design approach to refine the model to lower abstraction levels step-by-step by adding implementation details. ESL models are usually written in C-based System-level Description Languages (SLDLs), and contain the essential features, such as clear structure and hierarchy, separate computation and communication, and explicit parallelism. The validation of ESL models typically relies on simulation. Fast yet accurate simulation is highly desirable for efficient and effective system design.
In this dissertation, we present out-of-order parallel discrete event simulation (OoO PDES), a novel approach for efficient validation of system-level designs by exploiting the parallel capabilities of todays multi-core PCs for system level description languages. OoO PDES breaks the global simulation-cycle barrier of traditional DE simulation by localizing the simulation time into each thread, carefully delivering notified events, and handling a dynamic management of simulation sets. Potential conflicts caused by parallel accesses to shared variables and out-of-order thread scheduling are prevented by an advanced predictive static model analyzer in the compiler. As such, OoO PDES allows the simulator to effectively exploit the parallel processing capability of the multi-core system to achieve fast speed simulation without loss of simulation and timing accuracy.
We perform simulation experiments on both highly parallel benchmark examples and real-world embedded applications, including a JPEG image encoder, an edge detector, a MP3 audio decoder, a H.264 video decoder, and a H.264 video encoder. Experimental results show that our approach can achieve significant simulation speedup on multi-core simulation hosts with negligible compilation cost.
Based on our parallel simulation infrastructure, we then propose a tool flow for dynamic race condition detection to increase the observability for parallel ESL model development. This helps the designer to quickly narrow down the debugging targets in faulty ESL models with parallelism. This approach helps to reveal a number of risky race conditions in our in- house embedded multi-media application models and enabled us to safely eliminate these hazards. Our experimental results also show very little overhead for race condition diagnosis during compilation and simulation.
Overall, our work provides an advanced parallel simulation infrastructure for efficient and effective system-level model validation and development. It helps embedded system designers to build better products in shorter time.
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Ledbetter, John C. "Event Order in the Biathlon Does Not Have an Effect on Metabolic Response." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc500834/.
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The purpose of this study was to examine the effects of event order on a cycling(C)/running(R) or R/C biathlon. Eight experienced male biathlete/triathletes with a mean age of 24.9 + 4.6 yr formed the sample of the study. Results show no significant interaction effects on oxygen consumption peak, oxygen consumption during steady-state, ventilation, and heart rate when C/R or R/C are performed at 70% oxygen consumption peak for subsequent R and C respectively. These results seem to indicate that the biathlete/triathlete is efficient in both C and R to the extent that event order does not significantly interact with metabolic response in submaximal cycling and running.
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Romitelli, Antonia. "A CRISPR-based flow cytometric approach to to assess the order of transcriptional events." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1195095.
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Recently many devices have been developed to record and store information in living cells, however most of them are limited by their use only in prokaryotes or only allow us to obtain snapshots of cellular events at a given time. Many efforts are ongoing to develop systems to test the order in which different events occur in a mammalian cell system to obtain a specific phenotype. Based on this, I set up an assay to verify a posteriori the order in which two different transcriptional events occur in a mammalian cell through a genome editing tool based on the CRISPR/Cas9 system. Artificial DNA targets for a pair of sgRNAs and Cas9 have been interspersed in a cassette containing the coding sequence of four fluorescent proteins. Transcription of Cas9 and of a specific sgRNAs will trigger double strand breaks in the cassette and its recombination: from an initial state in which two fluorescent proteins are expressed, the recombination of the cassette will result in the loss/acquisition of the other fluorescent proteins in combinations dependent from the order in which the sgRNAs are transcribed.
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Carlestav, Martin, and André Paulsson. "Plant Simulation for Order Planning : A Discrete Event Simulation Project at Volvo Trucks in Umeå." Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104793.
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Abstract Volvo Trucks’ plant in Umeå produces the truck’s cab frame and the plant is divided into four production units, named ”driftsområden” (DO). Unlike the rest of the plant, who uses JIT manufacturing, DO2 uses traditional prediction based production. The management within Volvo Trucks suspects that the combination of prediction based production and JIT manufacturing entails unnecessary costs. At the same time they are uncertain if there is enough time for DO2 to produce the necessary components, in the given time frame, using JIT. It is important for Volvo Trucks to understand the consequences of making changes within DO2’s production parameters. This entails the need of a tool able to analyze how changes within DO2’s production will affect the total production of cabs. The problem is defined as: How can a macro simulation model be implemented and used in order to analyze how changes in production parameters for DO2 affect the total production for Volvo Trucks’ plant in Umeå? The result is an implemented simulation model in Plant Simulation. The result highlights some components that are crucial when modelling the DO2 production unit: The excel files, named “kapabilitetsfiler”, used to supervise and ensure that DO2 produces according to the production planning, contain lots of data which would be overwhelming retrieving elsewhere. The sales predictions, together with the dependency between the cab articles, are necessary. Without these components it is impossible to conduct a prediction based production planning, which fuels the production in DO2. The usage of a “black-box” to represent the production units proceeding DO2 is desirable, since it illustrates how the total production is affected due to changes in DO2. A simulation model that has an appropriate level of detail is a must. If the level of detail is too high the simulation model will run slowly and use too much computational power.
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Kauppinen, A. (Antti). "The event of organisational entrepreneurship:disrupting the reigning order and creating new spaces for play and innovation." Doctoral thesis, Oulun yliopisto, 2012. http://urn.fi/urn:isbn:9789514298479.
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Abstract Organisational entrepreneurship is an entrepreneurial event. By-products of such events may include the emergence of business organisations. In this study, I discuss the event of organisational entrepreneurship fostered by organisational creativity. An event of organisational entrepreneurship can happen in the context of social spaces for play and innovation. In these social spaces, novelty, movement, and change are outcomes of the role of organisational entrepreneurship in society. The dissertation consists of four essays. Prior research defines organisational entrepreneurship as a relationship between the managerial order and organisational creativity. This particular relationship, rather than being a precise state, is one that problematises the tradition of studying entrepreneurship as a sub-discipline of management. Researchers tend to be drawn to studying the entrepreneurial order, but less so the play and innovation that contribute to the creativity aspect. Whilst permitting space for play and innovation have been acknowledged to be crucial, the role of play and innovation between the discourses of business opportunities and entrepreneurial becoming has not been discussed. The literature review in this study shows that understanding the concepts of entrepreneurial actions and processes is key to explicating organisational entrepreneurship. Hence, the principal research question of this study is: how do entrepreneurial actions and processes frame the very nature of the event of organisational entrepreneurship? There are four sub-questions (one for each essay) that illustrate how an entrepreneurial event is about creation of new spaces for play and innovation. The purpose of this study is to show what role playfulness and innovativeness play in organisational entrepreneurship. I have empirically investigated how international business opportunities may be created through entrepreneurial actions in a multinational collaboration project, and found that social learning is at the heart of the process. In addition, I have examined an entrepreneurial process through the story of an up-and-coming stand-up comedian. This study shows that the entrepreneurial process emerges from the desire to become-Other. The entrepreneurial stories of this qualitative study come from two data sets (conducted in Finland and in Denmark). The research outline problematises the prior research, in which storytelling is rarely used. The dissertation concludes by suggesting that one role of playfulness and innovativeness is to create business opportunities and entrepreneurial becomingTiivistelmä Organisatorinen yrittäjyys on yksi yrittäjämäinen tila. Tällaisessa tilassa monenlaisten sivutuotteiden, kuten liikeyrityksen, syntyminen on mahdollista. Organisatorinen luovuus tukee näiden tilojen luomiseen liittyvää tekemistä ja prosesseja. Yrittäjämäiset tilat ovat mahdollisia konteksteissa, joita tässä väitöskirjatutkimuksessa tutkittiin tiloina leikille ja innovaatioille. Näiden tilojen ansiosta uutuus, liike ja muutos ovat mahdollisia ja ne kuvaavat organisatorisen yrittäjyyden roolia yhteiskunnassa. Tämä väitöskirja on neljän esseen kokoelma. Aikaisempi tutkimus määrittelee organisatorisen yrittäjyyden johtajuuden hallinnan ja organisatorisen luovuuden väliseksi suhteeksi. Ennemmin kuin jokin tila tällä jatkumolla suhde sinänsä kyseenalaistaa tradition, joka tutkii yrittäjyyttä johtajuustutkimuksen koulukuntana. Siinä tutkimusintressi on ollut hallinta, mutta ei kovin usein leikki ja innovaatiot. Vaikka leikki ja innovaatiot on nähty tärkeinä asioina, siitä huolimatta niiden roolia linkkinä liiketoimintamahdollisuuksien luomisen ja yrittäjämäiseksi tulemisen välillä ei ole vielä kovin hyvin tutkittu. Tämän tutkimuksen kirjallisuuskatsaus osoittaa, että yrittäjämäiset toiminnot ja prosessit ovat keskeisimmät käsitteet organisatorisessa yrittäjyydessä. Tutkimuksen päätutkimuskysymys kuuluu: kuinka yrittäjämäiset toiminnot ja prosessit rajaavat organisatorisen yrittäjyyden syvimmän luonteen yrittäjämäisenä tapahtumana? Tutkimuksen tarkoitus on näyttää, mikä rooli leikinomaisuudella ja innovatiivisuudella on organisatorisessa yrittäjyydessä silloin, kun se nähdään yrittäjämäisenä tilana. Tutkin empiirisesti kansainvälisten liiketoimintamahdollisuuksien luomista ja sitä, miten se tapahtuu monikansallisessa yhteistyöprojektissa. Tuloksena löysin, että se on sosiaalista oppimista. Lisäksi tutkin yrittäjämäiseksi tulemisen prosessia standup-koomikoksi tulevan henkilön kautta. Se näyttää, että syy yrittäjämäisen prosessin ilmentymiselle on intohimo tulla toiseksi. Tutkimuksen yrittäjämäiset tarinat perustuvat kahdelle aineiston lähteelle (tehty Suomessa ja Tanskassa). Tutkimusasetelma kyseenalaistaa tutkimuksen, jossa tarinankerrontaa on käytetty harvoin. Tulokset osoittavat, että leikinomaisuuden ja innovatiivisuuden rooli on luoda uusia liiketoimintamahdollisuuksia ja yrittäjämäiseksi tulemisen prosesseja
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Breakell, Fernandez Leigh [Verfasser], and Barbara [Akademischer Betreuer] Hoehle. "Investigating word order processing using pupillometry and event-related potentials / Leigh Breakell Fernandez ; Betreuer: Barbara Hoehle." Potsdam : Universität Potsdam, 2016. http://d-nb.info/1218400587/34.
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Huang, Zhongdong. "RULES BASED MODELING OF DISCRETE EVENT SYSTEMS WITH FAULTS AND THEIR DIAGNOSIS." UKnowledge, 2003. http://uknowledge.uky.edu/gradschool_diss/340.
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Failure diagnosis in large and complex systems is a critical task. In the realm of discrete event systems, Sampath et al. proposed a language based failure diagnosis approach. They introduced the diagnosability for discrete event systems and gave a method for testing the diagnosability by first constructing a diagnoser for the system. The complexity of this method of testing diagnosability is exponential in the number of states of the system and doubly exponential in the number of failure types. In this thesis, we give an algorithm for testing diagnosability that does not construct a diagnoser for the system, and its complexity is of 4th order in the number of states of the system and linear in the number of the failure types. In this dissertation we also study diagnosis of discrete event systems (DESs) modeled in the rule-based modeling formalism introduced in [12] to model failure-prone systems. The results have been represented in [43]. An attractive feature of rule-based model is it's compactness (size is polynomial in number of signals). A motivation for the work presented is to develop failure diagnosis techniques that are able to exploit this compactness. In this regard, we develop symbolic techniques for testing diagnosability and computing a diagnoser. Diagnosability test is shown to be an instance of 1st order temporal logic model-checking. An on-line algorithm for diagnosersynthesis is obtained by using predicates and predicate transformers. We demonstrate our approach by applying it to modeling and diagnosis of a part of the assembly-line. When the system is found to be not diagnosable, we use sensor refinement and sensor augmentation to make the system diagnosable. In this dissertation, a controller is also extracted from the maximally permissive supervisor for the purpose of implementing the control by selecting, when possible, only one controllable event from among the ones allowed by the supervisor for the assembly line in automaton models.
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Alghwiri, Alaa Ali. "Parking System Analysis Using Discrete Event Simulation." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1405364577.
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GAVARDI, ALESSANDRO. "Next-to-next-to-leading order predictions for diboson production in hadronic scattering combined with parton showers." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/402370.
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In questo lavoro presento le implementazioni di due processi di produzione di una coppia di bosoni elettrodeboli (EW) dallo scattering di due adroni in due diversi generatori di eventi Monte Carlo all'ordine next-to-next-to-leading (NNLO) nella cromodinamica quantistica (QCD) combinati con la parton shower (PS).
Nella prima parte della tesi discuto l'implementazione del processo di produzione di due coppie di leptoni privi di massa con lo stesso sapore e carica opposta dallo scattering protone-protone all'interno del generatore di eventi Monte Carlo Geneva. Dopo aver brevemente introdotto il metodo Geneva, fornisco una descrizione dettagliata di due delle sue funzioni recentemente implementate. Dopo aver passato gli eventi attraverso la parton shower di Pythia8, mostro infine diverse distribuzioni di interesse fenomenologico e le confronto con i dati degli esperimenti ATLAS e CMS al Large Hadron Collider (LHC).
Il generatore di eventi Geneva consente di abbinare il calcolo NNLO con la resummazione all'ordine logaritmico next-to-next-to-leading primo (NNLL') della zero-jettiness e quella all'ordine logaritmico next-to-leading (NLL) della one-jettiness. Poiché il contributo della risommazione è differenziale nel solo parametro della N-jettiness, può essere utilizzato per generare eventi soltanto dopo aver fornito la sua dipendenza dall'intero spazio delle fasi di radiazione. Le funzioni utilizzate a questo scopo sono dette funzioni di splitting e devono essere normalizzate in modo da non compromettere l'accuratezza della risommazione. In questo lavoro presento un modo per normalizzarle on the fly, che fornisce una migliore stabilità all'integrazione Monte Carlo. Tuttavia, tale metodo richiede il calcolo analitico di diversi limiti dello spazio delle fasi che dipendono dalle mappe utilizzate per proiettare le configurazioni con N+1 partoni di stato finale su quelle con N partoni di stato finale. Dopo aver descritto tutte le proiezioni attualmente disponibili in Geneva, presento un calcolo dettagliato della normalizzazione delle corrispondenti funzioni di splitting. Successivamente discuto la sottrazione all'ordine next-to-leading (NLO) delle singolarità infrarosse di QCD per qualsiasi processo di produzione di un singoletto di colore. Poiché Geneva richiede l'integrazione Monte Carlo on-the-fly delle ampiezze reali sottratte, mostro un modo per ottimizzare l'efficienza dell'integrazione che può essere particolarmente utile per i processi in cui il calcolo degli elementi di matrice reali è computazionalmente impegnativa.
Nella seconda parte della tesi discuto l'implementazione del processo di produzione di una coppia di fotoni da uno scattering protone-protone all'interno del generatore di eventi Monte Carlo Powheg Box + MiNNLOPS. Tale processo richiede un trattamento dedicato poiché è afflitto da divergenze di elettrodinamica quantistica (QED) nel limite in cui qualsiasi fotone diventa collineare a un quark. Dopo aver brevemente introdotto il generatore di eventi Powheg Box e il metodo MiNNLOPS, presento gli strumenti appositamente creati per questo calcolo. Comincio descrivendo una tecnica generale per trattare qualsiasi processo con una sezione d'urto Born divergente nel generatore di eventi Powheg Box senza applicare alcun taglio a livello di generazione. Presento quindi una mappa che impedisce che le configurazioni finite dal punto di vista della QED con un partone di stato finale siano proiettate su configurazioni singolari senza partoni di stato finale. Infine discuto alcune modifiche alla versione originale del metodo MiNNLOPS volte a ridurre l'impatto dei contributi spuri oltre il NNLO. Dopo aver passato gli eventi attraverso la parton shower di Pythia8, concludo mostrando diverse distribuzioni di interesse fenomenologico e confrontandole con i dati di LHC più recenti dall'esperimento ATLAS.In this work, I present the implementations of two processes of electroweak (EW) boson pair production from hadronic scattering within two different Monte Carlo event generators at next-to-next-to-leading order (NNLO) in quantum chromodynamics (QCD) combined with parton showers (PS). In the first part of the work, I discuss the implementation of the process of production of two same-flavor opposite-charge pairs of massless leptons from proton-proton scattering within the Geneva Monte Carlo event generator. After briefly introducing the Geneva method, I provide a detailed description of two of its newly-implemented features. After passing the events through the Pythia8 parton shower, I finally show several distributions of phenomenological interest and compare them with the data from the ATLAS and CMS experiments at the Large Hadron Collider (LHC). The Geneva event generator provides a framework for matching the NNLO calculation with the next-to-next-to-leading logarithmic prime (NNLL') resummation of the zero-jettiness and next-to-leading logarithmic (NLL) resummation of the one-jettiness. Since the contribution from the resummation is only differential in the N-jettiness parameter, it can be used for generating events only after providing its dependence on the full radiation phase space. The functions used for this purpose are called splitting functions and must be normalized so as not to spoil the accuracy of the resummation. In this work, I present a way of normalizing them on the fly, which provides better stability to the Monte Carlo integration. However, such a method requires the analytic computation of several phase-space boundaries, which depend on the mappings used for projecting the configurations with N+1 final-state partons onto those with N final-state partons. After describing all the mappings currently available in Geneva, I present a detailed calculation of the normalization of the corresponding splitting functions. I then discuss the next-to-leading order (NLO) subtraction of the infrared QCD singularities for any process of production of a color singlet. Since Geneva requires the on-the-fly Monte Carlo integration of the subtracted real amplitudes, I show a way to optimize the efficiency of the integration, which can be particularly useful for processes where the evaluation of the real matrix elements is computationally demanding. In the second part of the work, I discuss the implementation of the process of production of a photon pair from a proton-proton scattering within the Powheg Box + MiNNLOPS Monte Carlo event generator. Such a process requires a dedicated treatment since it is plagued by quantum electrodynamics (QED) divergences in the limit where any photons become collinear to a quark. After briefly introducing the Powheg Box event generator and the MiNNLOPS method, I present the dedicated tools devised for this calculation. I begin by describing a generic way to deal with any process with a divergent Born cross section in the Powheg Box event generator without applying any generation-level cuts. I then present a mapping that prevents QED-finite configurations with one final-state parton from being projected to singular configurations with no final-state partons. Finally, I discuss several modifications to the original version of the MiNNLOPS method aimed at reducing the size of spurious contributions beyond NNLO. After passing the events through the Pythia8 parton shower, I conclude by showing several distributions of phenomenological interest and comparing them with the most recent LHC data from the ATLAS experiment.
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Karcher, David S. [Verfasser], Uwe [Akademischer Betreuer] Nestmann, Uwe [Gutachter] Nestmann, Sabine [Gutachter] Glesner, and Thomas [Gutachter] Hildebrandt. "Event structures with higher-order dynamics / David S. Karcher ; Gutachter: Uwe Nestmann, Sabine Glesner, Thomas Hildebrandt ; Betreuer: Uwe Nestmann." Berlin : Universitätsverlag der TU Berlin, 2019. http://d-nb.info/1182424058/34.
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Swanson, Eric C. "Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/765.
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Cellular senescence is thought to play an essential role in many biological functions including tumor suppression and organismal aging. Senescent cells, which are permanently removed from the cell cycle, can be found both in vivo in many different tissue types and in vitro within cultures of non-immortalized cells. Despite their inability to proliferate, these cells persist and remain metabolically active for indefinite periods of time. This physiologic process occurs in response to a variety of cellular insults including oxidative stress, shortened telomeres, constitutive oncogene expression, and DNA damage, and can be initiated by upregulation of one of the two known senescent pathways, involving p16/Rb or p53/p21. The senescent cell phenotype is also characterized by changes to cell and nuclear morphology and to the secretory profile of the cell.
Related to changes in nuclear morphology, epigenetic modifications to the packaging of DNA are thought to be key to the initiation and maintenance of the senescence program. While a large number of earlier studies focused on the findings that senescent cells gain regions of condensed heterochromatin, often in the form of Senescent Associated Heterochromatin Foci (SAHF), this thesis work shows that there is a marked loss of heterochromatin in the peri/centromeric regions of the genome. In fact, both α-satellite and satellite II sequences across the genome distend in a striking and unanticipated fashion; this can be readily visualized by fluorescence in situ hybridization (FISH) as their structure changes from a condensed spot to highly elongated and fine thread-like signals. We have termed this exceptional decondensation of constitutive heterochromatin Senescence Associated Distension of Satellites (SADS). Importantly, a series of experiments shows that SADS is both a consistent and an early event in the cell senescence process, which occurs as a result of every senescence induction method examined. We also observed that this distension was characteristic of both human and murine cells and in vivo in human benign Prostatic Intraepithelial Neoplasia (PIN) tissue. Furthermore, unlike SAHF formation, SADS can occur due to the activation of either of the two senescence pathways, p16/Rb or p53/p21.
Additionally, the cytological dimensions of the thread-like satellite signals indicates that SADS represents “unraveling” of DNA on an unprecedented scale. Thus, it was surprising that this event was not facilitated by changes to several canonical histone modifications associated with condensed heterochromatin, namely H3K9Me3, H3K27Me3, or H3K4Me3, nor is it caused by loss of DNA methylation. Consequently, we believe that this marked distension of satellite DNA is due to changes in higher-order folding of the chromatin fiber. This is important for understanding fundamental events in the cell senescence process, but also provides a unique system for study of chromatin packaging that may provide new insights into the organization of DNA well beyond nucleosome packaging and the ten nanometer fiber. In fact, initial super resolution images of SADS suggest that the satellite sequences may be organized into domains or “globules”. Hence, we suggest that the changes to satellite sequence packaging may be facilitated by changes to higher-order nuclear structural proteins, such as LaminB1, which is reduced in senescent cells.
Finally, this work provides analysis of the literature and preliminary experiments to consider the possibility that there are increased levels of cell senescence in Down syndrome (trisomy 21) cells. As individuals with Down syndrome (DS) experience many manifestations of premature aging (including early-onset Alzheimer’s Disease), have a resistance to solid tumor formation, are more susceptible to oxidative stress, and are trisomic for several genes implicated in causing senescence, our analysis provides plausibility for the hypothesis that accelerated rates of senescence may play a significant role in DS physiology. We also provide results of preliminary studies and outline the next steps for experimentation, using DS fibroblasts and a unique genetically engineered DS iPS cell system. As a final note, the quantification of cell senescence in trisomic versus disomic cells for these experiments relies substantially on the new single-cell marker of senescence discovered and established by this theses work, the Senescence-Associated Distension of Satellites.
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Swanson, Eric C. "Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/765.
Full textAbstract:
Cellular senescence is thought to play an essential role in many biological functions including tumor suppression and organismal aging. Senescent cells, which are permanently removed from the cell cycle, can be found both in vivo in many different tissue types and in vitro within cultures of non-immortalized cells. Despite their inability to proliferate, these cells persist and remain metabolically active for indefinite periods of time. This physiologic process occurs in response to a variety of cellular insults including oxidative stress, shortened telomeres, constitutive oncogene expression, and DNA damage, and can be initiated by upregulation of one of the two known senescent pathways, involving p16/Rb or p53/p21. The senescent cell phenotype is also characterized by changes to cell and nuclear morphology and to the secretory profile of the cell.
Related to changes in nuclear morphology, epigenetic modifications to the packaging of DNA are thought to be key to the initiation and maintenance of the senescence program. While a large number of earlier studies focused on the findings that senescent cells gain regions of condensed heterochromatin, often in the form of Senescent Associated Heterochromatin Foci (SAHF), this thesis work shows that there is a marked loss of heterochromatin in the peri/centromeric regions of the genome. In fact, both α-satellite and satellite II sequences across the genome distend in a striking and unanticipated fashion; this can be readily visualized by fluorescence in situ hybridization (FISH) as their structure changes from a condensed spot to highly elongated and fine thread-like signals. We have termed this exceptional decondensation of constitutive heterochromatin Senescence Associated Distension of Satellites (SADS). Importantly, a series of experiments shows that SADS is both a consistent and an early event in the cell senescence process, which occurs as a result of every senescence induction method examined. We also observed that this distension was characteristic of both human and murine cells and in vivo in human benign Prostatic Intraepithelial Neoplasia (PIN) tissue. Furthermore, unlike SAHF formation, SADS can occur due to the activation of either of the two senescence pathways, p16/Rb or p53/p21.
Additionally, the cytological dimensions of the thread-like satellite signals indicates that SADS represents “unraveling” of DNA on an unprecedented scale. Thus, it was surprising that this event was not facilitated by changes to several canonical histone modifications associated with condensed heterochromatin, namely H3K9Me3, H3K27Me3, or H3K4Me3, nor is it caused by loss of DNA methylation. Consequently, we believe that this marked distension of satellite DNA is due to changes in higher-order folding of the chromatin fiber. This is important for understanding fundamental events in the cell senescence process, but also provides a unique system for study of chromatin packaging that may provide new insights into the organization of DNA well beyond nucleosome packaging and the ten nanometer fiber. In fact, initial super resolution images of SADS suggest that the satellite sequences may be organized into domains or “globules”. Hence, we suggest that the changes to satellite sequence packaging may be facilitated by changes to higher-order nuclear structural proteins, such as LaminB1, which is reduced in senescent cells.
Finally, this work provides analysis of the literature and preliminary experiments to consider the possibility that there are increased levels of cell senescence in Down syndrome (trisomy 21) cells. As individuals with Down syndrome (DS) experience many manifestations of premature aging (including early-onset Alzheimer’s Disease), have a resistance to solid tumor formation, are more susceptible to oxidative stress, and are trisomic for several genes implicated in causing senescence, our analysis provides plausibility for the hypothesis that accelerated rates of senescence may play a significant role in DS physiology. We also provide results of preliminary studies and outline the next steps for experimentation, using DS fibroblasts and a unique genetically engineered DS iPS cell system. As a final note, the quantification of cell senescence in trisomic versus disomic cells for these experiments relies substantially on the new single-cell marker of senescence discovered and established by this theses work, the Senescence-Associated Distension of Satellites.
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RE, EMANUELE. "Next - to - leading order qcd corrections to shower Monte Carlo event generators: single vector- boson and single- top hadroproduction." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7455.
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Morbiato, Anna. "Word order and sentence structure in Mandarin Chinese: new perspectives." Doctoral thesis, Università Ca' Foscari Venezia, The University of Sydney, 2018. http://hdl.handle.net/10278/3716543.
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Word order (WO) is one of the most fascinating and investigated topics in Mandarin Chinese (MC) linguistics, and many accounts have been proposed on different WO patterns and constructions. However, despite the large amount of research, several WO related issues remain rather controversial. Crucially, no unified consensus exists on the relationship between WO and the different dimensions of the language (i.e. semantics, syntax and pragmatics), and on how these levels interact with each other. The present thesis’s aim is twofold: (1) identify the categories that are useful to account for WO patterns and variations in MC; (2) examine in greater depth the syntactic, semantic and pragmatic factors that influence word order in MC, as well as how they interact and impose constraints on possible WO variations. The novelty of the approach lies on three aspects: (i) a typological, comparative perspective that benefits from cross-linguistic investigation of WO phenomena in other languages; (ii) a bottom up approach that employs cross-linguistically validated typological tools (e.g., GR tests, or constituenthood tests) aimed at conducting the analysis on a language-internal basis, and (iii) an empirical approach: the analysis avails itself of natural linguistic data, mainly drawn from corpora, and relies on acceptability checks with native speakers. Overall, the thesis highlights that WO patterns and constructions are determined by the interplay of different factors and constraints. It also highlights that, for the sake of clarity and ambiguity avoidance, WO constraints are hierarchically organized, and WO freezing phenomena occur to allow disambiguation of participants in the described event.
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Price, Gregory Walter. "Application of time series analysis techniques to the human electroencephalogram in real time, in order to synchronise event related potentials (ERPS) with background EEG." Thesis, Queensland University of Technology, 1995.
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Chen, Nan. "External and Internal Determinants Contributing to Event Participation and Destination Revisitation: A Sport Tourism Perspective." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/367326.
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Sport tourism is one of the fastest growing sectors in the tourism industry and is gaining burgeoning research interest from academia. However, there are limited studies combining sport and tourism research to understand sport tourists’ attitudes and decision-making related to an event-host destination. This PhD research addresses this gap by examining the formation and change of sport tourists’ destination attitudes in order to understand why sport tourists travel to a specific place to attend sport events and why they decide to return to this destination in the future as leisure vacationers.
Specifically, the objectives of this research are threefold. Firstly, to identify and examine factors influencing sport tourist’s initial attitude formation towards a specific event-host destination, thereby understanding their initial travel decisions. Secondly, to assess how the actual visit experience of sport tourists contributes to their attitude change towards the destination. Thirdly, to reveal how the sport tourists’ post-visit destination attitude changes over time, thereby understanding the temporal effect of their future revisit decisions.
Destination image (DI), a construct normally regarded as interchangeable with destination attitude, is adopted to operationalise the destination attitude of sport tourists because of its longstanding popularity in tourism research. Moreover, a tripartite attitudinal perspective was utilised to examine how the three components of DI (i.e., cognition, affect, and conation) change when the overall DI undergoes a change. The Psychological Continuum Model (PCM) provides the theoretical framework to guide this investigation. Combining the staged decision-making process model and the literature of DI formation and change with the hierarchical PCM provides the rationale for the conceptual model of this study.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith Business School
Griffith Business School
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Nilsson, Linnea, and Linnea Tiensuu. "Optimization of Storage Categorization : A simulation based study of how categorization strategies affect the order fulfillment time in a multi-picker warehouse." Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-148537.
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The most costly and labor-intensive activity for almost every warehouse is the order picking process and a key challenge for manufacturing companies is to store parts in an efficient way. Therefore, to minimize the order retrieval time when picking from a storage, the need of a sufficient storage categorization strategy becomes vital. One of the logistics centers at Scania in Södertälje stores parts that will be transported to the chassis assembly and the assembly of gearboxes and axles when needed in the production. In one of the storage areas at the logistics center, namely the PS storage, the forklift drivers picking from the storage have experienced congestion in the storage aisles and that it might be possible to reduce the order fulfillment time when picking the orders. This master thesis aims to investigate the possibility of optimizing the picking process in the PS storage, with respect to the order fulfillment time for the forklift drivers, with categorization of the goods. This has been analyzed with a heuristic optimization approach and with the use of a discrete event simulation model, where different categorization strategies have been applied on the storage and compared to the current state. By categorizing the goods in the PS storage, a reduction of the order fulfillment time can be done of around 4% - 5% compared to the current state with all tested categorization strategies. The strategy which has been shown to give the largest improvement is by categorizing the parts in the storage according to their final delivery address at the production line, which would reduce the order fulfillment time by 5.03% compared to the current state. With this categorization method, parts that are picked on the same route are located close to each other.
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Tepe, Mete. "Market Reaction To Rights Offering Announcements In The Turkish Stock Market." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614044/index.pdf.
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This study examines the market reaction to rights offering announcements in Turkey. Even though the topic is extensively studied in the finance literature, there is still research going on for emerging markets. The first part of this study measures market reaction to rights offering announcements for six different information arrival dates. The results are significantly negative except for the case of the announcement of the rights offering period. Additionally, the sample is divided into two sub-periods as before and after the 2001 crisis. The results show that there is a significant difference in market reaction and this difference is attributed to the change in economic policy after the 2001 crisis. The second part of the study examines the determinants of this market reaction and the findings suggest that bonus issues are positively related and there is also evidence that firms time their equity issues. The third part analyzes the long term performance of equity issuing firms in two subgroups as financial and non-financial firms. The results provide evidence of a negative performance and this finding is consistent with the results of previous studies.
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Chan, Wing-mee Mimi. "Policing public order events." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31967139.
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Chan, Wing-mee Mimi, and 陳詠美. "Policing public order events." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31967139.
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Trần, Thế Quang. "Unfolding based verification of concurrent infinite-state systems." Thesis, Bordeaux 1, 2009. http://www.theses.fr/2009BOR13832/document.
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Nous proposons une technique de dépliage pour vérifier les systèmes concurrents infinis bien structurés. Certaines propriétés d'intérêt comme la bornitude, la couverture et la terminaison sont décidables grâce à la bonne structure de ces systèmes. D'autre part, le dépliage réduit efficacement l'explosion combinatoire en exploitant l'ordre partiel entre les événements des systèmes concurrents. Nous proposons une modélisation par structure d'événements pour des systèmes bien structurés élémentaires, tels les compteurs et les files de communication. Le dépliage d'un réseau de structures d'événements étant une structure d'événements, nous proposons ensuite une approche hiérarchique à la modélisation et à la vérification des systèmes, qui préserve la bonne structure. Enfin, nous proposons une technique d'élimination des événements redondants. La mise en œuvre de notre approche dans l'outil ESU nous permet de conclure à son efficacitéWe propose an unfolding technique for verifying concurrent infinite-state systems that are well-structured. Some properties of interest such as boundedness, coverability and termination are decidable thanks to the well-structure of these systems. Moreover, the unfolding effectively reduces the combinatorial explosion by exploiting the partial order between events of concurrent systems. We propose a modelization using event structures for basic well-structured systems, such as counters and communication channels. As the unfolding of a synchronized product of event structures is an event structure, we obtain a hierarchical approach to modeling as well as to verifying systems, which preserves the well-structure. Finally, we propose a technique for eliminating redundant events. The implementation of our approach in the ESU tool allows us to conclude on its efficiency
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Pike, Francis. "The public order policing of community-based events." Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/2794/.
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This thesis offers an exploratory investigation of public order policing in the context of events that are staged for members of different types of communities. The research utilises a qualitative case study methodology that combines observational fieldwork conducted during the planning and staging of four events with the interviewing of 27 participants involved in this process. Relative to other public order contexts (e.g. political protest, industrial disputes, community disorder), academic research on the type of • community-based' events that formed the basis of the field research is lacking. The presented empirical findings reveal that a number of micro, meso and macro factors impacted on the prospects for safety and order at the observed events. An evaluation of existing public order related analytic accounts highlight both opportunities and limitations in explaining these factors. In response, an analytic framework is developed which employs Pierre Bourdieu's concepts of the habitus and the field. This reveals that the prospects for safety and order are enhanced when the police and organisers are engaged in close working practices which increase trust, cohesive decisionmaking, communication and consistency. The resulting policy implications are intended as 'good practice' guidance for both the police and organisers in relation to planning and staging community-based events, and identifying potential 'beyond the event' benefits. Although this thesis is exploratory and care is required in making generalisations, future research could determine whether the presented analytic framework and the policy implications are applicable to other public order contexts.
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Ku, Siu-fai, and 古兆輝. "A study of ethical policing of public order events." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B50255253.
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Kook, Kyung Soo Soo. "Dynamic Model Based Novel Findings in Power Systems Analysis and Frequency Measurement Verification." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/27761.
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This study selects several new advanced topics in power systems, and verifies their usefulness using the simulation. In the study on ratio of the equivalent reactance and resistance of the bulk power systems, the simulation results give us the more correct value of X/R of the bulk power system, which can explain why the active power compensation is also important in voltage flicker mitigation. In the application study of the Energy Storage System(ESS) to the wind power, the new model implementation of the ESS connected to the wind power is proposed, and the control effect of ESS to the intermittency of the wind power is verified. Also this study conducts the intensive simulations for clarifying the behavior of the wide-area power system frequency as well as the possibility of the on-line instability detection.
In our POWER IT Laboratory, since 2003, the U.S. national frequency monitoring network (FNET) has been being continuously operated to monitor the wide-area power system frequency in the U.S. Using the measured frequency data, the event of the power system is triggered, and its location and scale are estimated. This study also looks for the possibility of using the simulation technologies to contribute the applications of FNET, finds similarity of the event detection orders between the frequency measurements and the simulations in the U.S. Eastern power grid, and develops the new methodology for estimating the event location based on the simulated N-1 contingencies using the frequency measurement.
It has been pointed out that the simulation results can not represent the actual response of the power systems due to the inevitable limit of modeling power systems and different operating conditions of the systems at every second. However, in the circumstances that we need to test such an important infrastructure supplying the electric energy without taking any risk of it, the software based simulation will be the best solution to verify the new technologies in power system engineering and, for doing this, new models and better application of the simulation should be proposed.
Conducting extensive simulation studies, this dissertation verified that the actual X/R ratio of the bulk power systems is much lower than what has been known as its typical value, showed the effectiveness of the ESS control to mitigate the intermittence of the wind power from the perspective of the power grid using the newly proposed simulation model of ESS connected to the wind power, and found many characteristics of the wide-area frequency wave propagation. Also the possibility of using the simulated responses of the power system for replacing the measured data could be confirmed and this is very promising to the future application of the simulation to the on-line analysis of the power systems based on the FNET measurements.Ph. D.
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Liu, Zhi Kang. "Some norm inequalities of the commutator for even-order tensors." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3691384.
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Montini, Marco. "Assaying the order of transcriptional events in cells through CRISPR/Cas9." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1073088.
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Cells and organisms are complex systems whose life and development result from the action of entangled cellular pathways and machineries. Phenotypes are triggered by the order in which cellular events occur. Yet, while interrogating individual events is relatively straightforward, it is difficult to assess the specific order and relevance of events when several cooperate to induce different phenotypes. Recently, new techniques greatly improved our ability to obtain information from cells by enabling the longitudinal tracking of molecular events into genomic DNA. Yet, these tools are still unable to relay the order in which different events occur.
During my PhD I set up a system to assess the order of two transcriptional events leading to a specific phenotype in mammalian cells. To this aim I am exploited the CRISPR/Cas9 system to trigger the recombination of an artificial DNA cassette in which barcode sequences are interspersed with two sets of guideRNA targets. The transcription of Cas9 and of two sgRNAs induces double-strand breaks and the recombination of the cassette, depending upon the order in which the sgRNAs have been transcribed. Sequencing of the recombined cassette thus allows to ascertain the sequence of recombinational events leading to the recombination (i.e., the order in which the sgRNAs were used to target the cassette), which in turn acts as a proxy of the order of the cellular events leading to the expression of the individual sgRNAs. I have obtained proof of principle of my assay. Having obtained a stable cell line carrying a single copy of the reporter cassette, I sequentially expressed in HEK293T cells the individual Cas9/sgRNA pairs, using different orders of expression. I then recovered the cells and amplified the reporter cassette: Sanger sequencing of the barcodes present in the recombined cassette confirmed that the system worked as intended.
In order to simplify the system and make it more robust, I have redesigned the cassette by replacing the DNA barcodes with cassettes driving the expression of four fluorescent reporters. This allows me to visualize the recombination outcome by flow cytometry using live cells: only two fluorescent reporters are expressed in the cells in their initial status, and the sequential recombination of the artificial cassette will drive the expression of the other fluorescent proteins. Each combination of fluorescence reflects a well-defined order of transcriptional activation of the guideRNAs. Beyond making the procedure more straightforward, the use of fluorescent reporters and flow cytometry allow me to assess each cell individually. A defined order of activation for these factors could explain the differences observed in re-programmability among cells, and could be exploited to improve our reprogramming techniques.
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Hall, Suzannah. "Generating Linear Orders of Events for Geospatial Domains." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/HallSuzannah2004.pdf.
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Hopkins, Britney Henderson Johnny. "Multiplicity of positive solutions of even-order nonhomogeneous boundary value problems." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5323.
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Vaheid, Halimeh. "Generation and Validation of di-Higgs events in the 4τ final state." Thesis, Uppsala universitet, Högenergifysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355744.
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The Higgs self-coupling has a vital role by giving a deeper understanding of the Higgs particle. Furthermore, the way it opens to physics beyond the SM, encourages us to do MC simulationstudies for varying λ_hhh . In this project, we investigate the effects of choosing different values for λ_hhh on the kinematics of all particles involved in the hh → τ τ τ τ decay channel and the resultsare compared with what we get from the SM prediction of λ_hhh .The data show that λ_hhh more close to the SM trilinear Higgs self-coupling results in generatingthe Higgs particles with the higher masses and higher momenta. On the other hand, for the moremassive Higgs bosons we have more energetic neutrinos in the final states which escape from thedetector without being detected.
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Araújo, José. "Design, Implementation and Validation of Resource-Aware and Resilient Wireless Networked Control Systems." Doctoral thesis, KTH, Reglerteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-152535.
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Networked control over wireless networks is of growing importance in many application domains such as industrial control, building automation and transportation systems. Wide deployment however, requires systematic design tools to enable efficient resource usage while guaranteeing close-loop control performance. The control system may be greatly affected by the inherent imperfections and limitations of the wireless medium and malfunction of system components. In this thesis, we make five important contributions that address these issues. In the first contribution, we consider event- and self-triggered control and investigate how to efficiently tune and execute these paradigms for appropriate control performance. Communication strategies for aperiodic control are devised, where we jointly address the selection of medium-access control and scheduling policies. Experimental results show that the best trade-off is obtained by a hybrid scheme, combining event- and self-triggered control together with contention-based and contention-free medium access control. The second contribution proposes an event-based method to select between fast and slow periodic sampling rates. The approach is based on linear quadratic control and the event condition is a quadratic function of the system state. Numerical and experimental results show that this hybrid controller is able to reduce the average sampling rate in comparison to a traditional periodic controller, while achieving the same closed-loop control performance. In the third contribution, we develop compensation methods for out-of-order communications and time-varying delays using a game-theoretic minimax control framework. We devise a linear temporal coding strategy where the sensor combines the current and previous measurements into a single packet to be transmitted. An experimental evaluation is performed in a multi-hop networked control scenario with a routing layer vulnerability exploited by a malicious application. The experimental and numerical results show the advantages of the proposed compensation schemes. The fourth contribution proposes a distributed reconfiguration method for sensor and actuator networks. We consider systems where sensors and actuators cooperate to recover from faults. Reconfiguration is performed to achieve model-matching, while minimizing the steady-state estimation error covariance and a linear quadratic control cost. The reconfiguration scheme is implemented in a room heating testbed, and experimental results demonstrate the method's ability to automatically reconfigure the faulty system in a distributed and fast manner. The final contribution is a co-simulator, which combines the control system simulator Simulink with the wireless network simulator COOJA. The co-simulator integrates physical plant dynamics with realistic wireless network models and the actual embedded software running on the networked devices. Hence, it allows for the validation of the complete wireless networked control system, including the study of the interactions between software and hardware components.QC 20140929
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Jones, Lee K., and Richard C. 1943 Larson. "Efficient Computation of Probabilities of Events Described by Order Statistics and Applications to Queue Inference." Massachusetts Institute of Technology, Operations Research Center, 1994. http://hdl.handle.net/1721.1/5131.
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This paper derives recursive algorithms for efficiently computing event probabilities related to order statistics and applies the results in a queue inferencing setting. Consider a set of N i.i.d. random variables in [0, 1]. When the experimental values of the random variables are arranged in ascending order from smallest to largest, one has the order statistics of the set of random variables. Both a forward and a backward recursive O(N3 ) algorithm are developed for computing the probability that the order statistics vector lies in a given N-rectangle. The new algorithms have applicability in inferring the statistical behavior of Poisson arrival queues, given only the start and stop times of service of all N customers served in a period of continuous congestion. The queue inference results extend the theory of the "Queue Inference Engine" (QIE), originally developed by Larson in 1990 [8]. The methodology is extended to a third O(N 3 ) algorithm, employing both forward and backward recursion, that computes the conditional probability that a random customer of the N served waited in queue less than r minutes, given the observed customer departure times and assuming first come, first served service. To our knowledge, this result is the first O(N3 ) exact algorithm for computing points on the in-queue waiting time distribution function,conditioned on the start and stop time data. The paper concludes with an extension to the computation of certain correlations of in-queue waiting times. Illustrative computational results are included throughout.
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Mesa, Akhilesh. "A Methodology to Design Systems to Support Fulfillment of Online Grocery Orders." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1610708317139122.
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Jones, Lee K., and Richard C. 1943 Larson. "Efficient Computation of Probabilities of Events Described by Order Statistics and Application to a Problem of Queues." Massachusetts Institute of Technology, Operations Research Center, 1991. http://hdl.handle.net/1721.1/5159.
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Consider a set of N i.i.d. random variables in [0, 1]. When the experimental values of the random variables are arranged in ascending order from smallest to largest, one has the order statistics of the set of random variables. In this note an O(N3) algorithm is developed for computing the probability that the order statistics vector lies in a given rectangle. The new algorithm is then applied to a problem of statistical inference in queues. Illustrative computational results are included.
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Al‐Abbadi, Tabarik. "Radiology Reporting Preferences of Non‐Radiologist Ordering Clinicians: Prose? Do you even list?" Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/623185.
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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.The purpose of this survey was to expand the limited knowledge regarding non-radiologist physician preferences in radiology report styles and content.
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Haouari, Lobna. "MODELISATION ET SIMULATION DE L’INTRODUCTION DE TECHNOLOGIES RFID DANS DES SYSTEMES DE CONFIGURATION A LA DEMANDE." Thesis, Saint-Etienne, EMSE, 2012. http://www.theses.fr/2012EMSE0680/document.
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L'IDentification par Radio-Fréquences (RFID) permet une identification rapide et efficace des objets. Dans les systèmes de personnalisation de masse, elle promet un apport considérable grâce à sa capacité à gérer des flux d'information complexes caractérisant ce type de systèmes.Dans cette thèse, nous étudions les impacts de la RFID sur les systèmes de configuration à la demande (CTO). Nous nous basons sur un cas réel pour apporter une mesure fiable et directement exploitable. La littérature à ce sujet offre souvent des mesures sommaires, théoriques ou qualitatives, d'où l'originalité de la thèse.L'étude est réalisée par une approche de simulation à évènements discrets et évalue l'apport des technologies RFID à deux niveaux. Le premier concerne des changements directs du système (e.g. accélération des maintes vérifications caractérisant la CTO, libération de ressources...). Ces changements influencent la performance du système en termes de temps de séjour, de taux de retard des commandes, etc. Le deuxième niveau concerne des changements profonds tirant profit d'une visibilité accrue des produits et de la facilité d'une collecte de données rigoureuse. Ces changements se focalisent sur l'allocation dynamique de la charge de travail. La remise en question des processus à l'occasion de l'introduction d'une technologie RFID constitue un point original en raison du manque de publications soulignantsuffisamment cet avantage.Nos expérimentations ont montré que les apports des technologies RFID dans un système CTO sont indéniables. De plus, repenser le fonctionnement du système afin d'exploiter plus profondément le potentiel de la technologie accroit les bénéficesRadio Frequency IDentification allows quick and secure identification of objects. In mass customisation systems, RFID technologies can be peculiarly efficient, because they are able to support the complex flows of information which characterize these systems.In this study, we focus on RFID technologies effects on configuration to order (CTO) systems.We base the research on an existing case in order to obtain reliable information directly usable by decision makers. The rarity of studies offering quantitative, detailed and real case based measures makes the originality of this thesis.RFID technology implementation's effect is analysed by a discrete event simulation approach and is presented in two levels:The first level relates direct changes brought about by RFID (e.g. faster execution of the many checks due to the wide range of products, reduced workload for resources…). These changes have an impact on system's performance in terms of lead time, late orders' rate, etc.The second level is axed on deeper changes occurring due to the increased product visibility and the ease of collecting large amounts of data with an RFID technology.These changes mainly focus on the dynamic allocation of workload. Reconsidering of processes and proposing changes deeper than the simple direct technology impact is a breakthrough, in this study, because of the lack of publications highlighting this benefit adequately.In conclusion, RFID contribution in CTO systems and, extensively, in assembly to order systems may be undeniable. Moreover, beyond the direct technology impact, rethinking how the system works by exploiting the deeper potential of technology can increase profits
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Sun, Xun. "Twin solutions of even order boundary value problems for ordinary differential equations and finite difference equations." [Huntington, WV : Marshall University Libraries], 2009. http://www.marshall.edu/etd/descript.asp?ref=1014.
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Wylie, John D. (John David). "The impact of equity market fragmentation and the increased frequency of order book events on market and instrument choice." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28825.
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This dissertation examines the impact of differential implicit and explicit transaction costs on market and instrument choice when liquidity has fragmented. Contributions to the literature are made by addressing a number of fundamental questions that have received scarce consideration in the existing literature.
The empirical literature on market choice and the impact of fragmentation on market quality focuses on the spread and depth dimensions of liquidity, given that these are the first—order determinants of a transaction’s implicit cost. However, seminal theoretical literature identifies quote resiliency, defined as the rate at which new passive orders arrive, as an incremental dimension of liquidity. The first study of this dissertation extends the extant empirical literature on market choice to consider the relative contribution of liquidity dimensions, particularly resiliency, to the utility a trader derives when choosing a market from alternatives. Resiliency is likely to be of importance in an environment characterised by high—frequency interactions, as resilient quotes partially mitigate the risk that an offer to supply liquidity is withdrawn while an aggressive order is in transmission to the chosen market. Unlike the previous literature, which models competing markets one at a time, this study develops a single model for the choice decision across all fragmented markets. This parameterisation is significant as it allows the relative importance of the various dimensions of liquidity to be directly compared.
The second study fills a void in the burgeoning literature on the market quality impact of heightened participation by algorithmic traders. Previous published studies have only examined the impact of increased algorithmic participation on individual markets. This study exploits the natural experiment presented by the duopolistic market for trading FTSE 100 index constituents shortly after the November 2007 introduction of the Markets in Financial Instruments Directive in Europe. The behaviour of passive offers to supply liquidity which are withdrawn at varying frequencies is contrasted for the incumbent London Stock Exchange and the entrant Chi—X Multilateral Trading Facility. The event of order cancellation is used to proxy participation by algorithmic traders on both markets and allows this study to further differentiate itself from the scarce existing literature by testing for Granger causality between heightened algorithmic participation and intraday volatility. Weak evidence is identified which suggests that proportionally greater participation by algorithmic traders does not catalyse future volatility. This result is then explored in a seemingly unrelated regression framework which effectively ‘conditions’ on cross-market events.
The third study examines the temporal relationship between contracts for difference (CFDs) traded over-the-counter and exchange-traded cash equities. While the extant literature robustly considers temporal relationships between a range of derivatives and their underlying securities, none of this literature examines over-the-counter trading in CF Ds. A stamp
duty exemption for CFDs in the United Kingdom creates an explicit
transaction cost asymmetry which has fuelled the rapid growth of the CFD
market and may be likely to attract informed traders to this instrument. This
study identifies incremental support for the previously documented
importance of transaction costs and leverage to informed traders selecting
an instrument from alternatives. Previous literature suggests price discovery
for cash equities is concentrated on exchanges instead of the over—thecounter
market. This study capitalises on the unique structure of the CFD
market in the United Kingdom to explore the established notion that the
process of over-the-counter negotiation tends to screen out informed traders
when interactions are repeated.
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Hanson, James Vincent Michael. "The perceived timing of events across different sensory modalities : a psychophysical investigation of multisensory time perception in humans." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4290.
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The experiments reported within this thesis use psychophysical techniques to examine the factors which determine perceived multisensory timing in humans. Chapters 1 and 2 describe anatomical and psychophysical features of temporal processing, respectively, whilst Chapter 3 introduces the reader to psychophysical methods. Chapter 4 examines the relationship between two measures of sensory latency, reaction time (RT) and crossmodal temporal order judgment (TOJ). Despite task and attentional manipulations the two measures do not correlate, suggesting that they measure some fundamentally different aspect(s) of temporal perception. Chapter 5 examines the effects of adaptation to asynchronous stimulus pairs on perceived audiovisual (AV), audiotactile (AT) and visuotactile (VT) temporal order. Significant temporal shifts are recorded in all three conditions. Evidence is also presented showing that crossmodal TOJs are intransitive. Chapter 6 shows that concurrent adaptation to two sets of asynchronous AV stimulus pairs causes perceived AV temporal order to recalibrate at two locations simultaneously, and that AV asynchrony adaptation effects are significantly affected by observers' attention during adaptation. Finally, Chapter 7 shows that when observers are accustomed to a physical delay between motor actions and sensory events, an event presented at a reduced delay appears to precede the causative motor action. The data are well-described by a simple model based on a strong prior assumption of physical synchrony between motor actions and their sensory consequences.
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Scharp, Till. "Systems biology approaches to somatic cell reprogramming reveal new insights into the order of events, transcriptional and epigenetic control of the process." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/17056.
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Die Reprogrammierung somatischer Zellen hat sich kürlich als leistungsfähige Technik für die Herstellung von induzierten pluripotenten Stammzellen (iPS Zellen) aus terminal differenzierten Zellen bewährt. Trotz der großen Hoffnung, die sie speziell im Bezug auf patientenspezifische Stammzelltherapie darstellt, gibt es viele Hindernisse auf dem Weg zur Anwendung in der Humanmedizin, die sich von niedrigen Effizienzen bei der technischen Umsetzung bis hin zur unerwünschten Integration von Onkogenen in das menschliche Genom erstrecken. Aus diesem Grund ist es unabdingbar, unser Verständnis der zugrundeliegenden Prozesse und Mechanismen zu vertiefen. Durch neue Datengewinnungsmethoden und stetig wachsende biologische Komplexität hat sich der Denkansatz der Systembiologie in den letzten Jahrzehnten stark etabliert und erfährt eine fortwährende Entwicklung seiner Anwendbarkeit auf komplexe biologische und biochemische Zusammenhänge. Verschiedene mathematische Modellierungsmethoden werden auf den Reprogrammierungsprozess angewendet um Engpässe und mögliche Effizienz-Optimierungen zu erforschen. Es werden topologische Merkmale eines Pluripotenznetzwerkes untersucht, um Unterschiede zu zufällig generierten Netzen und so topologische Einschränkungen des biologisch relevanten Netzwerkes zu finden. Die Optimierung eines Booleschen Modells aus einem selbst kuratierten Netzwerk in Bezug auf Genexpressionsdaten aus Reprogrammierungsexperimenten gewährt tiefgreifende Einblicke in die ersten Schritte und wichtigsten Faktoren des Prozesses. Der Transkriptionsfaktor SP1 spielt hierbei eine wichtige Rolle zur Induktion eines intermediären, transkriptionell inaktiven Zustands. Ein probabilistisches Boole''sches Modell verdeutlicht das Zusammenspiel epigenetischer und transkriptioneller Kontrollprozesse zusammen, um Pluripotenz- und Zelllinien-Entscheidungen in Reprogrammierung und Differenzierung zu treffen. Erklärungen für die geringe Effizienz werden versucht.Somatic Cell Reprogramming has emerged as a powerful technique for the generation of induced pluripotent stem cells (iPSCs) from terminally differentiated cells in recent years. Although holding great promises for future clinical development, especially in patient specific stem cell therapy, the barriers on the way to a human application are manifold ranging from low technical efficiencies to undesirable integration of oncogenes into the genome. It is thus indispensable to further our understanding of the underlying processes involved in this technique. With the advent of new data acquisition technologies and an ever-growing complexity of biological knowledge, the Systems Biology approach has seen an evolution of its applicability to the elaborate questions and problems of researchers. Using different mathematical modeling approaches the process of somatic cell reprogramming is examined to find out bottlenecks and possible enhancements of its efficiency. I analyze the topological characteristics of a pluripotency network in order to find differences to randomly generated networks and thus deduce constraints of the biologically relevant network. The optimization of a Boolean model from a curated network against early reprogramming gene expression profiles reveals profound insights into the first steps and most important factors of the process. The transcription factor SP1 emerges to play an important role in the induction of an intermediate, transcriptionally inactive state. A probabilistic Boolean network (PBN) illustrates the interplay of transcriptional and epigenetic regulatory processes in order to explain pluripotency and cell lineage decisions in reprogramming and differentiation. Explanations for the low reprogramming efficiencies are tried.
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Medeiros, Rodrigo Augusto Lima de. "Construção de significados no evento-situacional Usina Hidrelétrica Corumbá IV : desapropriações, re-ordenamentos e formação de uma ordem moral." reponame:Repositório Institucional da UnB, 2007. http://repositorio.unb.br/handle/10482/3419.
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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Sociais, Centro de Pesquisa e Pós-Graduação sobre as Américas, 2007.Submitted by Larissa Ferreira dos Angelos (ferreirangelos@gmail.com) on 2010-01-23T13:19:59Z No. of bitstreams: 1 2007_RodrigoAugustoLimadeMedeiros.pdf: 450840 bytes, checksum: c5c8dfd6088d3bebd1371fa541c9b8d9 (MD5)
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O objetivo desta dissertação é descrever e analisar as dinâmicas de mudanças provocadas e/ou negociadas no contexto de instalação/operação da usina hidrelétrica Corumbá IV. Observa-se que diferentes modos de simbolizar o território e seus recursos entram em concorrência, notadamente, moralidade camponesa, concepções ambientalistas e perspectivas desenvolvimentistas. A hipótese de pesquisa é a seguinte: as interações entre os diferentes atores e agências, no contexto da hidrelétrica, produzem um campo semântico próprio. Grosso modo, este trabalho atribui à situação social de construção da hidrelétrica as questões de representações, de atos rituais, de normas, de valores e de moralidades que compõem, polissemicamente, uma ordem de relações morais. A heterogeneidade dos atores envolvidos e a variedade de eventos compõem as complexas interações em torno da realidade da hidrelétrica, obrigando os atores a reordenarem e re-significarem suas posições e perspectivas. _______________________________________________________________________________ ABSTRACT
The aim of this thesis is to describe and analyze the dynamics of the changes occurred during the construction and operation of the Corumbá IV hydroelectric plant. In that period, one is able to observe the competition among different ways of symbolizing the territory and its resources, mainly, moral economy of the peasant, enterprising concepts of development and environmentalist perspectives. The hypothesis of this research is the following: In the hydroelectric context, relationships among social actors create an particular symbolic field. In other words, this work is about the social change, ritual deeds, rules and moral values constituents of a new symbolic order.
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Sclocchi, Antonio. "A new critical phase in jammed models : jamming is even cooler than before." Thesis, université Paris-Saclay, 2020. https://tel.archives-ouvertes.fr/tel-03179833.
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Au cours des vingt dernières années, un courant de recherche important a caractérisé la transition de brouillage, un point critique à température zéro des systèmes ayant des interactions répulsives à courte portée. Plusieurs de ses propriétés sont indépendantes de la dimension spatiale, avec des prédictions de champ moyen étant valables même pour les systèmes bidimensionnels. Dans cette thèse, nous montrons l’existence de ce comportement critique du point de brouillage ("jamming") dans toute une phase brouillée ("jammed"). Ce comportement est observé en étudiant le potentiel de répulsion linéaire dans les sphères molles et le modèle de champ moyen correspondant, c’est-à-dire le perceptron. Nous montrons que le point non différentiable du potentiel d’interaction produit un réseau de contact de sphères tangentes à chaque densité surcomprimée, même loin de la transition de jamming.Les réseaux de contact caractérisant les minima du système sont isostatiques, critiquement auto-organisés et marginalement stables. Dans la première partie, nous utilisons la théorie du champ moyen pour le cas du perceptron et nous la validons par des simulations numériques. Ensuite, nous utilisons des simulations numériques pour étudier le cas des sphères molles en deux et trois dimensions. Dans les deux cas, nous caractérisons la phase marginalement stable et nous montrons que les exposants critiques correspondent à ceux connus pour la transition de jamming. De plus, nous définissons un protocole de compression et nous étudions numériquement les propriétés statistiques des avalanches dans la phase critique du perceptron. Nos résultats sont en accord parfait avec la théorie sous-jacente. Ce travail montre l’existence d’une phase critique dans les dimensions finies dont la classe d’universalité correspond au jamming des sphères. Cela ouvre de nouvelles perspectives pour l’étude des verres marginalement stables et des paysages énergétiques qui leur sont associésOver the last two decades, an intensive stream of research has characterized the jamming transition, a zero-temperature critical point of systems with short-range repulsive interactions. Many of its properties are independent of spatial dimensionality, with mean-field scalings being valid even for two-dimensional systems. In this thesis, we show the existence of this critical behaviour not only at the jamming point, but also in an entire jammed phase. This is observed by studying the linear repulsive interaction potential for soft spheres and in its correspondent mean-field model, i.e. the perceptron. We show that the non-differentiable point in the interaction potential produces a contact network of tangent spheres at every overcompressed density, even far away from the jamming transition. The contact networks characterizing the minima of the system are isostatic, critically self-organized and marginally stable. First, we solve the mean-field theory for the perceptron case and we validate it through numerical simulations. Furthermore, we use numerical simulations to study the soft spheres case in two and three dimensions. In both cases, we characterize the marginally stable phase and we show that the critical exponents correspond to those known for the jamming transition. Moreover, we define a compression protocol and we study numerically the avalanche statistics in the critical phase of the perceptron. Our findings are strongly consistent with the underlying theory. This work shows the existence of a critical phase in finite dimensions whose universality class corresponds to the jamming of spheres. This opens new perspectives to study marginally stable glasses and their related energy landscapes
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Scharp, Till [Verfasser], Edda [Akademischer Betreuer] Klipp, Ralf [Akademischer Betreuer] Mrowka, and Nils [Akademischer Betreuer] Blüthgen. "Systems biology approaches to somatic cell reprogramming reveal new insights into the order of events, transcriptional and epigenetic control of the process / Till Scharp. Gutachter: Edda Klipp ; Ralf Mrowka ; Nils Blüthgen." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://d-nb.info/1060782936/34.
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Yuzer, Ahmet Hayrettin. "Modeling Of Asymmetric Intermodulation Distortion And Memory Effects Of Power Amplifiers." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613284/index.pdf.
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This dissertation is focused on developing a new passband behavioral model in order to account
for asymmetric intermodulation distortion resulted from memory effect.
First, a measurement setup is prepared to measure the AM/AM, AM/PM distortion, magnitudes
and the phases of intermodulation (IMD) and fundamental (FUND) components which
are created by the amplifier where phase is calculated only by measuring magnitudes. Then,
responses of a sample amplifier are measured for different excitation situations (center frequency
and tone spacing are swept).
A new modeling technique, namely Odd Order Modeling (OOM), is proposed which has unequal
time delay terms. The reason of unequal time delay addition is the change of effective
channel length according to the average power passing through that channel. These unequal
delays create asymmetry in the IMD components. General Power Series Expansion (GPSE)
model is also extracted, OOM and GPSE model performances are compared by using NMSE
metric. In order to improve model performance, even order terms with envelope of input are
added. It is mathematically proven that even order terms with envelope of the input have
contribution to IMD and FUND components&rsquo. This improved version of modeling is named as Even Order modeling (EOM). EOM model performance is compared with the others&rsquo
performance for two-tone excitation measurement results. It is shown that EOM gives the most accurate result. Model performance is checked for unequal four-tone signal as well. EOM model is applied to baseband DPD circuit after making some modifications. Model linearization performance is compared with the performances of the other memory polynomial modeling techniques.
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Долинний, А. В. "Адміністративно-правове забезпечення Національною поліцією України публічної безпеки і порядку під час проведення масових заходів." Thesis, Відкритий міжнародний університет розвитку людини "Україна", 2017. http://essuir.sumdu.edu.ua/handle/123456789/55172.
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Дисертаційна робота присвячена визначенню змісту та особливостей забезпечення Національною поліцією України публічної безпеки і порядку під час проведення масових заходів. Встановлюється сутність публічної безпеки і порядку як об’єкта адміністративно-правової охорони. Обґрунтовуються значення, принципи та особливості забезпечення публічної безпеки і порядку під час проведення масових заходів в Україні, аналізуються методологічні підходи до визначення суб’єктів і об’єкта забезпечення публічної безпеки і порядку під час проведення масових заходів, правові засади в цій сфері та місце серед них адміністративно-правового регулювання. Розкривається значення Національної поліції в системі суб’єктів забезпечення публічної безпеки і порядку, визначаються особливості її взаємодії з іншими суб’єктами, узагальнюються види та напрямки, форми та методи забезпечення Національною поліцією України публічної безпеки і порядку під час проведення масових заходів. Характеризується зарубіжний досвід забезпечення поліцією публічної безпеки і порядку під час проведення масових заходів і з’ясовуються можливості його використання в Україні. Визначаються заходи з удосконалення організаційних заходів забезпечення Національною поліцією України публічної безпеки і порядку під час проведення масових заходів і адміністративного законодавства, що регулює дану сферу.Диссертационная работа является одним из первых в отечественной административно-правовой науке комплексных исследований теоретикоправовых проблем административно-правового обеспечения Национальной полицией Украины публичной безопасности и порядка во время проведения массовых мероприятий. Исследование нацелено на определение содержания и особенностей обеспечения Национальной полицией Украины публичной безопасности и порядка во время проведения массовых мероприятий, путей совершенствования деятельности Национальной полиции Украины в данной сфере. Обосновывается необходимость обеспечения общественной безопасности и порядка при проведении массовых мероприятий в Украине, учитывая возможные угрозы, риски и негативные последствия, непосредственно на предупреждение, нейтрализацию и устранение которых нацелена деятельность многих субъектов обеспечения общественной безопасности и порядка, прежде всего Национальной полиции Украины. Соответственно, актуализируется проблема отсутствия специального законодательства в сфере организации и проведения массовых мероприятий и обеспечения органами полиции общественной безопасности и порядка во время массовых мероприятий. Основной акцент сделан на рассмотрении публичной безопасности и порядка во время массовых мероприятий как объекта административноправовой охраны и, соответственно, определении сущности данного понятия. Обосновываются значение, принципы и особенности обеспечения общественной безопасности и порядка при проведении массовых мероприятий в Украине. В связи с этим обобщаются и анализируются методологические подходы к определению субъектов и объекта обеспечения общественной безопасности и порядка во время массовых мероприятий, правовые основы обеспечения общественной безопасности и порядка при проведении массовых мероприятий в Украине и место среди них административно-правового регулирования. Особое внимание уделяется установлению места и статуса Национальной полиции в системе субъектов обеспечения общественной безопасности и порядка, определению особенностей ее взаимодействия с другими субъектами обеспечения общественной безопасности и порядка при проведении массовых мероприятий. Соответственно, определяются и анализируются виды и направления, формы и методы обеспечения Национальной полицией Украины публичной безопасности и порядка во время проведения массовых мероприятий. Изучается зарубежный опыт обеспечения полицией публичной безопасности и порядка во время проведения массовых мероприятий и определяются возможности его использования в Украине. Также предлагаются меры по совершенствованию организационных мер обеспечения Национальной полицией Украины публичной безопасности и порядка во время проведения массовых мероприятий и административного законодательства, регулирующих данную сферу.
The thesis is focused on defining the content and features of ensuring public safety and order by the National Police of Ukraine during mass events. The nature of public safety and order as the object of administrative and legal protection is established. The value, principles and features of ensuring public safety and order during mass events in Ukraine are grounded; the methodological approaches to determining the subject and object of ensuring public safety and order during mass events, legal principles in this area and among them administrative and legal regulation are analyzed. The significance of the National Police in the system of subjects of ensuring public safety and order is revealed; the peculiarities of its interaction with other subjects are defined; the types and directions, forms and methods of ensuring public safety and order during mass events by the National Police of Ukraine are summarized. International experience of ensuring public safety and order during mass events by the police is characterized; possibilities of its usage in Ukraine are formulated. Actions of improving organizational measures of ensuring public safety and order during mass events by the National Police of Ukraine and administrative legislation regulating this area are determined.
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Di, Méo Marion. "Une démocratie à l’épreuve des mouvements sociaux : le cas du Chili post-dictatorial de 1988 à nos jours." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0656.
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Cette thèse vise à rendre compte de l'évolution, au Chili, de la gestion des événements protestataires par les institutions en charge de l'ordre public depuis le retour à la démocratie en 1990. Il s'agit d'examiner la manière dont un pays autrefois gouverné par la répression encadre, une fois la démocratie retrouvée, les protestations de différents groupes de la société. La thèse interroge aussi l'existence d'un traitement différencié de la contestation en fonction du public mobilisé. L'enquête a été menée entre mars 2015 et mai 2017 et repose sur un matériau composé d'observations, d'entretiens, d'archives de presse. Ce travail est composé de trois parties. La première revient sur les éléments qui ont façonné le contexte politique chilien de la transition, largement défavorable à la contestation. Il s'agit également de s'intéresser aux caractéristiques et à la culture institutionnelle de la police en charge du maintien de l'ordre, en observant comment s'articulent le caractère militaire de cette institution et les fondements de la doctrine du maintien de l'ordre. Dans la seconde, les mobilisations des peuples autochtones et des étudiants chiliens sont longuement décryptées, en particulier la question de leur répertoire d'action et les interactions entre ces groupes, l'État chilien et les forces de l'ordre. La troisième partie est consacrée à la manière dont le passé récent du Chili devient l'enjeu de discours et de mobilisations, et s'intéresse de près à différentes journées de commémoration. Elle examine enfin les effets de la militarisation de la police sur le maintien de l'ordre, et sur les représentations du monde qui entourent ses pratiques professionnellesThis thesis aims to give an account of the evolution, in Chile, of the management of the protest events by the institutions in charge of public order since the return to democracy in 1990. It aims to examine the way in which a country once ruled by repression frames, once the democracy returned, the protests of different groups of society. The thesis also questions the existence of a differentiated treatment of the protest events according to the public mobilized. The investigation was conducted between March 2015 and May 2017 and is based on a material consisting of observations, interviews, press archives. This work is composed of three parts. The first examines the elements that have shaped the Chilean political context of the transition, which is largely unfavorable to collective action. It also analyzes the characteristics and the institutional culture of the police in charge of policing protest, by observing how are articulated the military character of this institution and the bases of the doctrine of protest policing. In the second, the mobilizations of the indigenous peoples and students of Chile are lengthily deciphered, in particular the question of their repertoire of action and the interactions between these groups, the Chilean State and the police forces. The third part is devoted to the way in which the recent past of Chile becomes the issue of speeches and mobilizations, and is closely interested in different days of commemoration. Finally, it examines the effects of police militarization on law enforcement, and on the representations of the world surrounding its professional practices
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Dakkoune, Amine. "Méthodes pour l'analyse et la prévention des risques d'emballement thermique Zero-order versus intrinsic kinetics for the determination of the time to maximum rate under adiabatic conditions (TMR_ad): application to the decomposition of hydrogen peroxide Risk analysis of French chemical industry Fault detection in the green chemical process : application to an exothermic reaction Analysis of thermal runaway events in French chemical industry Early detection and diagnosis of thermal runaway reactions using model-based approaches in batch reactors." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMIR30.
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L’histoire des événements accidentels dans les industries chimiques montre que leurs conséquences sont souvent graves sur les plans humain, environnemental et économique. Cette thèse vise à proposer une approche de détection et de diagnostic des défauts dans les procédés chimiques afin de prévenir ces événements accidentels. La démarche commence par une étude préalable qui sert à identifier les causes majeures responsables des événements industriels chimiques en se basant sur le retour d’expérience (REX). En France, selon la base de données ARIA, 25% des évènements sont dus à l’emballement thermique à cause d’erreurs d’origine humaine. Il est donc opportun de développer une méthode de détection et de diagnostic précoce des défauts dus à l’emballement thermique. Pour cela nous développons une approche qui utilise des seuils dynamiques pour la détection et la collecte de mesures pour le diagnostic. La localisation des défauts est basée sur une classification des caractéristiques statistiques de la température en fonction de plusieurs modes défectueux. Un ensemble de classificateurs linéaires et de diagrammes de décision binaires indexés par rapport au temps sont utilisés. Enfin, la synthèse de l'acide peroxyformique dans un réacteur discontinu et semi-continu est considérée pour valider la méthode proposée par des simulations numériques et ensuite expérimentales. Les performances de détection de défauts se sont révélées satisfaisantes et les classificateurs ont démontré un taux de séparabilité des défauts élevésThe history of accidental events in chemical industries shows that their human, environmental and economic consequences are often serious. This thesis aims at proposing an approach of detection and diagnosis faults in chemical processes in order to prevent these accidental events. A preliminary study serves to identify the major causes of chemical industrial events based on experience feedback. In France, according to the ARIA database, 25% of the events are due to thermal runaway because of human errors. It is therefore appropriate to develop a method for early fault detection and diagnosis due to thermal runaway. For that purpose, we develop an approach that uses dynamical thresholds for the detection and collection of measurements for diagnosis. The localization of faults is based on a classification of the statistical characteristics of the temperature according to several defectives modes. A multiset of linear classifiers and binary decision diagrams indexed with respect to the time are used for that purpose. Finally, the synthesis of peroxyformic acid in a batch and semi batch reactor is considered to validate the proposed method by numerical simulations and then experiments. Faults detection performance has been proved satisfactory and the classifiers have proved a high isolability rate of faults
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Zu, Xiaomin. "Monte-Carlo event generators at next-to-leading order." 2003. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-343/index.html.
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Chen, Yi-Chang, and 陳奕璋. "A Study of Informed Investors Order Strategies before Event Announcements." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/34960269747382007865.
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碩士淡江大學
財務金融學系碩士班
100
This study is to investigate informed investors order strategies before event announcements and all types of investors the possibility of informed investors. According to Chae (2005) defined the event classification, this study defines the dividend and earnings announcements as scheduled events, treasury shares and M & A announcements as unscheduled events, and then investigate informed investors order strategies before listed companies'' event announcements on Taiwan stock market. The empirical result show that, informed investors will prefer to submit the most aggressive limit order and large size order before dividend, earnings, and treasury shares announcements, and to submit less aggressive limit order and median size order before M&A announcements. Compared to individual investors, institutional investors (foreign investors, dealers, and other domestic corporations) are more likely to be informed investors. Before and after financial Tsunami, informed investors order strategies before event announcements are indeed different. In this paper, the main contribution are further clarify the informed investors preferences of order strategies, and the impact on informed investors order strategies by event announcements with different feature.
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Chang, Jen-Wei, and 張人偉. "An Event-driven Approach for Order Portfolio Scheduling of Semiconductor Fab." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/933uqp.
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碩士國立中央大學
工業管理研究所
94
Order portfolio scheduling problem, i.e. multiple orders scheduling problem considering terminate, suspend, preempt, and postpone of customer orders have become a critical issue in today’s semiconductor industry, especially, with the dynamic and complex characteristic. How to respond to customer as soon as possible and schedule orders in a rolling horizon without large makespan (completion time) have been an emergent task. Moreover, the activities to complete orders consume resource (equipment, machine, and labor…etc), and the resource may be scared and expensive. Not only the cost of consume resource is calculated, but also the resource contention occurs. Above time and cost trade off issue influence the resource allocation of production scheduling. In this thesis, an even-driven approach is adopted to develop a tradeoff framework for order portfolio scheduling/rescheduling in a semiconductor fab. This framework is proposed for assisting the management of multiple orders to resolve the allocation of a variety of resources. To provide the solution for the problem, four modules are built into the system: Monitoring and Control, Makespan Estimation, Cost Calculation, and Schedule Evaluation. In order to construct these modules, activity based costing (ABC), High Level Petri Net (HLPN) is employed in tandem. In addition, how to measure and select a preferred feasible schedule will be a dilemma. Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) solves such multi-attribute decision making (MADM) problem. The advantage of this system include:(1) the formal description of multiple orders of which different activities may occur concurrently;(2) the graphical representation of activity of orders with resource constraint, (3) the operational semantics for supporting simulation and analysis, (4) In response to the modification of current order portfolio or supplementary resource being added (removed), reallocating resource to the new set of orders